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Chemical Quotes (303 quotes)

... every chemical combination is wholly and solely dependent on two opposing forces, positive and negative electricity, and every chemical compound must be composed of two parts combined by the agency of their electrochemical reaction, since there is no third force. Hence it follows that every compound body, whatever the number of its constituents, can be divided into two parts, one of which is positively and the other negatively electrical.
Essai sur la théorie des proportions chemiques (1819), 98. Quoted by Henry M. Leicester in article on Bessel in Charles Coulston Gillespie (editor), Dictionary of Scientific Biography (1981), Vol. 2, 94.
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[About the mechanical properties of the molecules of a chemical substance being studied:] They could be measured, but that would have taken several months. So someone said, ‘Let’s get Teller in and make him guess the data.’ We got him into a room and locked the door, so no one else could get at him, and he asked questions and did some figuring at the blackboard. He got the answers in about two hours, not entirely accurately, of course, but—as we found out when we got around to verifying them—close enough for the purpose.
Recalls the first time she was ever really awed by mental abilities of Edward Teller. She had joined the Manhattan Project, and needed data on the physical properties of molecules of a certain substance to get started on her assigned task of calculating its chemical properties. As quoted in Robert Coughlan, 'Dr. Edward Teller’s Magnificent Obsession', Life (6 Sep 1954), 61.
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[Concerning] phosphorescent bodies, and in particular to uranium salts whose phosphorescence has a very brief duration. With the double sulfate of uranium and potassium ... I was able to perform the following experiment: One wraps a Lumière photographic plate with a bromide emulsion in two sheets of very thick black paper, such that the plate does not become clouded upon being exposed to the sun for a day. One places on the sheet of paper, on the outside, a slab of the phosphorescent substance, and one exposes the whole to the sun for several hours. When one then develops the photographic plate, one recognizes that the silhouette of the phosphorescent substance appears in black on the negative. If one places between the phosphorescent substance and the paper a piece of money or a metal screen pierced with a cut-out design, one sees the image of these objects appear on the negative. One can repeat the same experiments placing a thin pane of glass between the phosphorescent substance and the paper, which excludes the possibility of chemical action due to vapors which might emanate from the substance when heated by the sun's rays. One must conclude from these experiments that the phosphorescent substance in question emits rays which pass through the opaque paper and reduces silver salts.
[Although the sun is irrelevant, and he misinterprets the role of phosphorescence, he has discovered the effect of radioactivity.]
Read at French Academy of Science (24 Feb 1896). In Comptes Rendus (1896), 122, 420. As translated by Carmen Giunta on the Classic Chemistry web site.
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[Davy's] March of Glory, which he has run for the last six weeks—within which time by the aid and application of his own great discovery, of the identity of electricity and chemical attractions, he has placed all the elements and all their inanimate combinations in the power of man; having decomposed both the Alkalies, and three of the Earths, discovered as the base of the Alkalies a new metal... Davy supposes there is only one power in the world of the senses; which in particles acts as chemical attractions, in specific masses as electricity, & on matter in general, as planetary Gravitation... when this has been proved, it will then only remain to resolve this into some Law of vital Intellect—and all human knowledge will be Science and Metaphysics the only Science.
In November 1807 Davy gave his famous Second Bakerian Lecture at the Royal Society, in which he used Voltaic batteries to “decompose, isolate and name” several new chemical elements, notably sodium and potassium.
Letter to Dorothy Wordsworth, 24 November 1807. In Earl Leslie Griggs (ed.), The Collected Letters of Samuel Taylor Coleridge (1956), Vol. 3, 38.
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[O]ur long-term security is threatened by a problem at least as dangerous as chemical, nuclear or biological weapons, or indeed international terrorism: human-induced climate change. … The impacts of global warming are such that I have no hesitation in describing it as a “weapon of mass destruction.” Like terrorism, this weapon knows no boundaries. It can strike anywhere, in any form…
London Guardian (28 Jul 2003)
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[On gold, silver, mercury, platinum, palladium, rhodium, iridium, osmium:] As in their physical properties so in their chemical properties. Their affinities being weaker, (the noble metals) do not present that variety of combinations, belonging to the more common metals, which renders them so extensively useful in the arts; nor are they, in consequence, so necessary and important in the operations of nature. They do not assist in her hands in breaking down rocks and strata into soil, nor do they help man to make that soil productive or to collect for him its products.
From 13th Lecture in 1818, in Bence Jones, The Life and Letters of Faraday (1870), Vol. 1, 254.
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[On the future of Chemistry:] Chemistry is not the preservation hall of old jazz that it sometimes looks like. We cannot know what may happen tomorrow. Someone may oxidize mercury (II), francium (I), or radium (II). A mineral in Nova Scotia may contain an unsaturated quark per 1020 nucleons. (This is still 6000 per gram.) We may pick up an extraterrestrial edition of Chemical Abstracts. The universe may be a 4-dimensional soap bubble in an 11-dimensional space as some supersymmetry theorists argued in May of 1983. Who knows?
In George B. Kaufmann, 'Interview with Jannik Bjerrum and Christian Klixbull Jørgensen', Journal of Chemical Education (1985), 62, No. 11, 1005.
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[The chemical bond] First, it is related to the disposition of two electrons (remember, no one has ever seen an electron!): next, these electrons have their spins pointing in opposite directions (remember, no one can ever measure the spin of a particular electron!): then, the spatial distribution of these electrons is described analytically with some degree of precision (remember, there is no way of distinguishing experimentally the density distribution of one electron from another!): concepts like hybridization, covalent and ionic structures, resonance, all appear, not one of which corresponds to anything that is directly measurable. These concepts make a chemical bond seem so real, so life-like, that I can almost see it. Then I wake with a shock to the realization that a chemical bond does not exist; it is a figment of the imagination that we have invented, and no more real than the square root of - 1. I will not say that the known is explained in terms of the unknown, for that is to misconstrue the sense of intellectual adventure. There is no explanation: there is form: there is structure: there is symmetry: there is growth: and there is therefore change and life.
Quoted in his obituary, Biographical Memoirs of the Fellows of the Royal Society 1974, 20, 96.
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[The surplus of basic knowledge of the atomic nucleus was] largely used up [during the war with the atomic bomb as the dividend.] We must, without further delay restore this surplus in preparation for the important peacetime job for the nucleus - power production. ... Many of the proposed applications of atomic power - even for interplanetary rockets - seem to be within the realm of possibility provided the economic factor is ruled out completely, and the doubtful physical and chemical factors are weighted heavily on the optimistic side. ... The development of economic atomic power is not a simple extrapolation of knowledge gained during the bomb work. It is a new and difficult project to reach a satisfactory answer. Needless to say, it is vital that the atomic policy legislation now being considered by the congress recognizes the essential nature of this peacetime job, and that it not only permits but encourages the cooperative research-engineering effort of industrial, government and university laboratories for the task. ... We must learn how to generate the still higher energy particles of the cosmic rays - up to 1,000,000,000 volts, for they will unlock new domains in the nucleus.
Addressing the American Institute of Electrical Engineering, in New York (24 Jan 1946). In Schenectady Gazette (25 Jan 1946),
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[This] may prove to be the beginning of some embracing generalization, which will throw light, not only on radioactive processes, but on elements in general and the Periodic Law.... Chemical homogeneity is no longer a guarantee that any supposed element is not a mixture of several of different atomic weights, or that any atomic weight is not merely a mean number.
From Chemical Society's Annual Reports (1910), Vol. 7, 285. As quoted in Francis Aston in Lecture (1936) on 'Forty Years of Atomic Theory', collected in Needham and Pagel (eds.) in Background to Modern Science: Ten Lectures at Cambridge Arranged by the History of Science Committee, (1938), 100. Cited in Alfred Walter Stewart, Recent Advances in Physical and Inorganic Chemistry (1920), 198.
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[About reading Rachel Carson's Silent Spring, age 14, in the back seat of his parents' sedan. I almost threw up. I got physically ill when I learned that ospreys and peregrine falcons weren't raising chicks because of what people were spraying on bugs at their farms and lawns. This was the first time I learned that humans could impact the environment with chemicals. [That a corporation would create a product that didn't operate as advertised] was shocking in a way we weren't inured to.
As quoted by Eliza Griswold, in 'The Wild Life of “Silent Spring”', New York Times (23 Sep 2012), Magazine 39.
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[Pechblende] einer eigenthümlichen, selbstständigen metallischen Substanz bestehe. Es fallen folglich auch deren bisherige Benennungen, als: Ресhblende Eisenpecherz, hinweg, welche nun durch einen neuen ausschliessend bezeichnenden Namen zu ersetzen sind. Ich habe dazu den Namen: Uranerz (Uranium) erwählt; zu einigem Andenken, dass die chemische Ausfindung dieses neuen Metallkörpers in die Epoche der astronomischen. Entdeckung des Planeten Uranus gefallen sei.
[Pitchblende] consists of a peculiar, distinct, metallic substance. Therefore its former denominations, pitch-blende, pitch-iron-ore, &c. are no longer applicable, and must be supplied by another more appropriate name.—I have chosen that of uranite, (Uranium), as a kind of memorial, that the chemical discovery of this new metal happened in the period of the astronomical discovery of the new planet Uranus.
In original German edition, Beiträge Zur Chemischen Kenntniss Der Mineralkörper (1797), Vol. 2, 215. English edition, translator not named, Analytical Essays Towards Promoting the Chemical Knowledge of Mineral Substances (1801), 491. The new planet was discovered on 13 Mar 1781 by William Herschel, who originally named it Georgium Sidus (George's Star) to honour King George III.
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Compounds formed by chemical attraction, possess new properties different from those of their component parts... chemists have long believed that the contrary took place in their combination. They thought, in fact, that the compounds possessed properties intermediate between those of their component parts; so that two bodies, very coloured, very sapid, or insapid, soluble or insoluble, fusible or infusible, fixed or volatile, assumed in chemical combination, a shade or colour, or taste, solubility or volatility, intermediate between, and in some sort composed of, the same properties which were considered in their principles. This is an illusion or error which modern chemistry is highly interested to overthrow.
Quoted in A General System of Chemical Knowledge (1804), Vol. I, trans. W. Nicholson, 102-3.
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Dass die bis jetzt unzerlegten chemischen Elemente absolut unzerlegbare Stoffe seien, ist gegenwärtig mindestens sehr unwahrscheinlich. Vielmehr scheint es, dass die Atome der Elemente nicht die letzten, sondern nur die näheren Bestandtheile der Molekeln sowohl der Elemente wie der Verbindungen bilden, die Molekeln oder Molecule als Massentheile erster, die Atome als solche zweiter Ordnung anzusehen sind, die ihrerseits wiederum aus Massentheilchen einer dritten höheren Ordnung bestehen werden.
That the as yet undivided chemical elements are absolutely irreducible substances, is currently at least very unlikely. Rather it seems, that the atoms of elements are not the final, but only the immediate constituents of the molecules of both the elements and the compounds—the Molekeln or molecule as foremost division of matter, the atoms being considered as second order, in turn consisting of matter particles of a third higher order.
[Speculating in 1870, on the existence of subatomic particles, in opening remark of the paper by which he became established as co-discoverer of the Periodic Law.]
'Die Natur der chemischen Elemente als Function ihrer Atomgewichte' ('The Nature of the Chemical Elements as a Function of their Atomic Weight'), Annalen der Chemie (1870), supp. b, 354. Original German paper reprinted in Lothar Meyer and Dmitry Ivanovich Mendeleyev, Das natürliche System der chemischen Elemente: Abhandlungen (1895), 9. Translation by Webmaster, with punctuation faithful to the original, except a comma was changed to a dash to improve readability.
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Den förslags-mening: att olika element förenade med ett lika antal atomer af ett eller flere andra gemensamma element … och att likheten i krystallformen bestämmes helt och hållet af antalet af atomer, och icke af elementens.
[Mitscherlich Law of Isomerism] The same number of atoms combined in the same way produces the same crystalline form, and the same crystalline form is independent of the chemical nature of the atoms, and is determined only by their number and relative position.
Original Swedish from 'Om Förhållandet emellan chemiska sammansättningen och krystallformen hos Arseniksyrade och Phosphorsyrade Salter', Kungl. Svenska vetenskapsakademiens handlingar (1821), 4. In English as expressed later by James F.W. Johnston, 'Report on the Recent Progress and present State of Chemical Science', to Annual Meeting at Oxford (1832), collected in Report of the First and Second Meetings of the British Association for the Advancement of Science (1833), 422. A Google raw translation of the Swedish is: “The present proposal-sense: that various elements associated with an equal number of atoms of one or several other common elements … and that the similarity in: crystal shape is determined entirely by the number of atoms, and not by the elements.”
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Die Welt der chemischen Vorgänge gleicht einer Bühne, auf welcher sich in unablässiger Aufeinanderfolge Scene um Scene abspielt. Die handelnden Personen auf ihr sind die Elemente.
The world of chemical reactions is like a stage, on which scene after scene is ceaselessly played. The actors on it are the elements.
Original German quote in Mary Elvira Weeks, The Discovery of the Elements (1934), 2, citing Winkler, 'Ueber die Entdeckung neuer Elemente im Verlaufe der letzten fünfundzwanzig Jahre," Ber. (Jan 1897), 30, 13. Translation in Mary Elvira Weeks and Henry M. Leicester (ed.)The Discovery of the Elements (6th ed. 1956), 3.
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Dilbert: Wow! According to my computer simulation, it should be possible to create new life forms from common household chemicals
Dogbert: This raises some thorny issues.
Dilbert: You mean legal, ethical and religious issues?
Dogbert: I was thinking about parking spaces.
Dilbert comic strip (31 May 1989).
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Engineering, too, owes its most useful materials to the achievements of chemists in identifying, separating, and transforming materials: structural steel for the framework of bridges and buildings, portland cement for roadways and aqueducts, pure copper for the electrical industries, aluminum alloys for automobiles and airplanes, porcelain for spark plugs and electrical insulators. The triumphs of engineering skill rest on a chemical foundation.
In Fundamental Chemistry, and Elementary Textbook for College Classes (1936), 8.
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A catalyst is a substance which alters the velocity of a chemical reaction without appearing in the final products.
'Über Katalyse', Zeitschrift für Physikalische Chemie (1901), 7, 995-1004 as quoted in J. R. Partington, A History of Chemistry, Vol. 4 (1901), 599-600.
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A cell has a history; its structure is inherited, it grows, divides, and, as in the embryo of higher animals, the products of division differentiate on complex lines. Living cells, moreover, transmit all that is involved in their complex heredity. I am far from maintaining that these fundamental properties may not depend upon organisation at levels above any chemical level; to understand them may even call for different methods of thought; I do not pretend to know. But if there be a hierarchy of levels we must recognise each one, and the physical and chemical level which, I would again say, may be the level of self-maintenance, must always have a place in any ultimate complete description.
'Some Aspects of Biochemistry', The Irish Journal of Medical Science (1932), 79, 346.
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A cell of a higher organism contains a thousand different substances, arranged in a complex system. This great organized system was not discovered by chemical or physical methods; they are inadequate to its refinement and delicacy and complexity.
'The Cell in Relation to its Environment', Journal of the Maryland Academy of Sciences (1931), 2, 25.
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A chemical compound once formed would persist for ever, if no alteration took place in surrounding conditions. But to the student of Life the aspect of nature is reversed. Here, incessant, and, so far as we know, spontaneous change is the rule, rest the exception—the anomaly to be accounted for. Living things have no inertia and tend to no equilibrium.
From Address (22 Jul 1854) delivered at St. Martin’s Hall, published as a pamphlet (1854), 7, and collected in 'Educational Value of Natural History Sciences', Lay Sermons, Addresses, and Reviews (1870), 75.
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A chemical name should not be a phrase, it ought not to require circumlocutions to become definite; it should not be of the type “Glauber’s salt”, which conveys nothing about the composition of the substance; it should recall the constituents of a compound; it should be non-committal if nothing is known about the substance; the names should preferably be coined from Latin or Greek, so that their meaning can be more widely and easily understood; the form of the words should be such that they fit easily into the language into which they are to be incorporated.
(1782) As quoted in Archibald Clow, Chemical Revolution: A Contribution to Social Technology (1952, 1992), 618.
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A Dr van’t Hoff of the veterinary college at Utrecht, appears to have no taste for exact chemical investigation. He finds it a less arduous task to mount Pegasus (evidently borrowed from the veterinary school) and to proclaim in his La Chemie dans l’espace how, during his bold fight to the top of the chemical Parnassus, the atoms appeared to him to have grouped themselves together throughout universal space. … I should have taken no notice of this matter had not Wislicenus oddly enough written a preface to the pamphlet, and not by way of a joke but in all seriousness recommended it a worthwhile performance.
'Signs of the Times', Journal fur Praktische Chemie, 15, 473. Trans. W. H. Brock.
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A German once has said of the Chemical Laboratory in Munich: “In diesem Hause stinkt es sehr, Dies kommt von Adolf Baeyer her.” [It stinks a lot in this house; this comes from Adolf Baeyer.]
From 'What Can the Modern Chemist Learn From the Old Alchemy?', Introductory Lecture (1917), delivered at Cornell University, written in German, translated by L.F. Audrieth, and published in Salts, Acids, and Bases: Electrolytes Stereochemistry (1929), 1, as Vol. 4 of the George Fisher Baker Non-Resident Lectureship in Chemistry at Cornell University. Translation of German part of above quote by Webmaster using Google Translate.
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A great advantage of X-ray analysis as a method of chemical structure analysis is its power to show some totally unexpected and surprising structure with, at the same time, complete certainty.
In 'X-ray Analysis of Complicated Molecules', Nobel Lecture (11 Dec 1964). In Nobel Lectures: Chemistry 1942-1962 (1964), 83.
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A physician’s subject of study is necessarily the patient, and his first field for observation is the hospital. But if clinical observation teaches him to know the form and course of diseases, it cannot suffice to make him understand their nature; to this end he must penetrate into the body to find which of the internal parts are injured in their functions. That is why dissection of cadavers and microscopic study of diseases were soon added to clinical observation. But to-day these various methods no longer suffice; we must push investigation further and, in analyzing the elementary phenomena of organic bodies, must compare normal with abnormal states. We showed elsewhere how incapable is anatomy alone to take account of vital phenenoma, and we saw that we must add study of all physico-chemical conditions which contribute necessary elements to normal or pathological manifestations of life. This simple suggestion already makes us feel that the laboratory of a physiologist-physician must be the most complicated of all laboratories, because he has to experiment with phenomena of life which are the most complex of all natural phenomena.
From An Introduction to the Study of Experimental Medicine (1865), as translated by Henry Copley Greene (1957), 140-141.
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A plain, reasonable working man supposes, in the old way which is also the common-sense way, that if there are people who spend their lives in study, whom he feeds and keeps while they think for him—then no doubt these men are engaged in studying things men need to know; and he expects of science that it will solve for him the questions on which his welfare, and that of all men, depends. He expects science to tell him how he ought to live: how to treat his family, his neighbours and the men of other tribes, how to restrain his passions, what to believe in and what not to believe in, and much else. And what does our science say to him on these matters?
It triumphantly tells him: how many million miles it is from the earth to the sun; at what rate light travels through space; how many million vibrations of ether per second are caused by light, and how many vibrations of air by sound; it tells of the chemical components of the Milky Way, of a new element—helium—of micro-organisms and their excrements, of the points on the hand at which electricity collects, of X rays, and similar things.
“But I don't want any of those things,” says a plain and reasonable man—“I want to know how to live.”
In 'Modern Science', Essays and Letters (1903), 221-222.
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A study of Dr. [Florence] Sabin’s work shows the greatness of her achievement and the character of her mind. She has dealt with the primary and fundamental problem of the cell—the unit of plant and animal life. All through her investigations she has followed the cell, seeking the secret of differentiations by newer and finer methods, both physical and chemical. Always through her work runs the great strong, continuous cord of cell differentiations. This is one of the great concepts of man, for all life begins as a single cell. I have known and followed Dr. Sabin’s work since her student days, and have lately been more closely associated with her in her tuberculosis studies. She is all in mind and spirit and ideals that man or woman ever accomplishes. She belongs to the great students of both sexes, for when these have the brains and the will to work I see little difference.
In Genevieve Parkhurst, 'Dr. Sabin, Scientist: Winner Of Pictorial Review’s Achievement Award', Pictorial Review (Jan 1930), 2.
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A time will come, when fields will be manured with a solution of glass (silicate of potash), with the ashes of burnt straw, and with the salts of phosphoric acid, prepared in chemical manufactories, exactly as at present medicines are given for fever and goitre.
Agricultural Chemistry (1847), 4th edn., 186.
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According to the older view, for every single effect of a serum, there was a separate substance, or at least a particular chemical group... A normal serum contained as many different haemagglutinins as it agglutinated different cells. The situation was undoubtedly made much simpler if, to use the Ehrlich terminology... the separate haptophore groups can combine with an extremely large number of receptors in stepwise differing quantities as a stain does with different animal tissues, though not always with the same intensity. A normal serum would therefore visibly affect such a large number of different blood cells... not because it contained countless special substances, but because of the colloids of the serum, and therefore of the agglutinins by reason of their chemical constitution and the electrochemical properties resulting from it. That this manner of representation is a considerable simplification is clear; it also opens the way to direct experimental testing by the methods of structural chemistry.
'Die Theorien der Antikorperbildung ... ', Wiener klinische Wöchenschrift (1909), 22, 1623-1631. Trans. Pauline M. H. Mazumdar.
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Adrenalin does not excite sympathetic ganglia when applied to them directly, as does nicotine. Its effective action is localised at the periphery. The existence upon plain muscle of a peripheral nervous network, that degenerates only after section of both the constrictor and inhibitory nerves entering it, and not after section of either alone, has been described. I find that even after such complete denervation, whether of three days' or ten months' duration, the plain muscle of the dilatator pupillae will respond to adrenalin, and that with greater rapidity and longer persistence than does the iris whose nervous relations are uninjured. Therefore it cannot be that adrenalin excites any structure derived from, and dependent for its persistence on, the peripheral neurone. But since adrenalin does not evoke any reaction from muscle that has at no time of its life been innervated by the sympathetic, the point at which the stimulus of the chemical excitant is received, and transformed into what may cause the change of tension of the muscle fibre, is perhaps a mechanism developed out of the muscle cell in response to its union with the synapsing sympathetic fibre, the function of which is to receive and transform the nervous impulse. Adrenalin might then be the chemical stimulant liberated on each occasion when the impulse arrives at the periphery.
'On the Action of Adrenalin', Proceedings of the Physiological Society, 21 May 1904, in The Journal of Physiology 1904, 31, xxi.
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All of our experience indicates that life can manifest itself only in a concrete form, and that it is bound to certain substantial loci. These loci are cells and cell formations. But we are far from seeking the last and highest level of understanding in the morphology of these loci of life. Anatomy does not exclude physiology, but physiology certainly presupposes anatomy. The phenomena that the physiologist investigates occur in special organs with quite characteristic anatomical arrangements; the various morphological parts disclosed by the anatomist are the bearers of properties or, if you will, of forces probed by the physiologist; when the physiologist has established a law, whether through physical or chemical investigation, the anatomist can still proudly state: This is the structure in which the law becomes manifest.
In 'Cellular-Pathologie', Archiv für pathologische Anatomie und Physiologie und fur klinische Medizin (1855), 8, 19, as translated in LellandJ. Rather, 'Cellular Pathology', Disease, Life, and Man: Selected Essays by Rudolf Virchow (1958), 84.
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All the more recent work on alkaptonuria has... strengthened the belief that the homogentisic acid excreted is derived from tyrosin, but why alkaptonuric individuals pass the benzene ring of their tyrosin unbroken and how and where the peculiar chemical change from tyrosin to homogentisic acid is brought about, remain unsolved problems.
'The Incidence of Alkaptonuria: A Study in Chemical Individuality', The Lancet, 1902, 2, 1616.
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All things on the earth are the result of chemical combination. The operation by which the commingling of molecules and the interchange of atoms take place we can imitate in our laboratories; but in nature they proceed by slow degrees, and, in general, in our hands they are distinguished by suddenness of action. In nature chemical power is distributed over a long period of time, and the process of change is scarcely to be observed. By acts we concentrate chemical force, and expend it in producing a change which occupies but a few hours at most.
In chapter 'Chemical Forces', The Poetry of Science: Or, Studies of the Physical Phenomena of Nature (1848), 235-236. Charles Dicken used this quote, with his own sub-head of 'Relative Importance Of Time To Man And Nature', to conclude his review of the book, published in The Examiner (1848).
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Almost all the world is natural chemicals, so it really makes you re-think everything. A cup of coffee is filled with chemicals. They've identified a thousand chemicals in a cup of coffee. But we only found 22 that have been tested in animal cancer tests out of this thousand. And of those, 17 are carcinogens. There are ten milligrams of known carcinogens in a cup of coffee and thats more carcinogens than youre likely to get from pesticide residues for a year!
Paper to the American Chemical Society, 'Pollution, Pesticides and Cancer Misconceptions.' As cited by Art Drysdale, 'Latest Insider News: Natural vs. Synthetic Chemical Pesticides' (14 Feb 1999), on the mitosyfraudes.org website. Bruce Ames has delivered a similar statistic in various other publications.
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Almost daily we shudder as prophets of doom announce the impending end of civilization and universe. We are being asphyxiated, they say, by the smoke of the industry; we are suffocating in the ever growing mountain of rubbish. Every new project depicts its measureable effects and is denounced by protesters screaming about catastrophe, the upsetting of the land, the assault on nature. If we accepted this new mythology we would have to stop pushing roads through the forest, harnessing rivers to produce the electricity, breaking grounds to extract metals, enriching the soil with chemicals, killing insects, combating viruses … But progress—basically, an effort to organise a corner of land and make it more favourable for human life—cannot be baited. Without the science of pomiculture, for example, trees will bear fruits that are small, bitter, hard, indigestible, and sour. Progress is desirable.
Anonymous
Uncredited. In Lachman Mehta, Stolen Treasure (2012), 117.
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Although we know nothing of what an atom is, yet we cannot resist forming some idea of a small particle, which represents it to the mind ... there is an immensity of facts which justify us in believing that the atoms of matter are in some way endowed or associated with electrical powers, to which they owe their most striking qualities, and amongst them their mutual chemical affinity.
[Summarizing his investigations in electrolysis.]
Experimental Researches in Electricity (1839), section 852. Cited in Laurie M. Brown, Abraham Pais, Brian Pippard, Twentieth Century Physics (1995), Vol. 1, 51.
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An egg is a chemical process, but it is not a mere chemical process. It is one that is going places—even when, in our world of chance and contingency, it ends up in an omelet and not in a chicken. Though it surely be a chemical process, we cannot understand it adequately without knowing the kind of chicken it has the power to become.
'The Changing Impact of Darwin on Philosophy', Journal of the History of Ideas (1961), 22, 457.
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An example of such emergent phenomena is the origin of life from non-living chemical compounds in the oldest, lifeless oceans of the earth. Here, aided by the radiation energy received from the sun, countless chemical materials were synthesized and accumulated in such a way that they constituted, as it were, a primeval “soup.” In this primeval soup, by infinite variations of lifeless growth and decay of substances during some billions of years, the way of life was ultimately reached, with its metabolism characterized by selective assimilation and dissimilation as end stations of a sluiced and canalized flow of free chemical energy.
In 'The Scientific Character of Geology', The Journal of Geology (Jul 1961), 69, No. 4, 458.
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An honest man, armed with all the knowledge available to us now, could only state that in some sense, the origin of life appears at the moment to be almost a miracle, so many are the conditions which would have had to have been satisfied to get it going. But this should not be taken to imply that there are good reasons to believe that it could not have started on the earth by a perfectly reasonable sequence of fairly ordinary chemical reactions. The plain fact is that the time available was too long, the many microenvironments on the earth’s surface too diverse, the various chemical possibilities too numerous and our own knowledge and imagination too feeble to allow us to be able to unravel exactly how it might or might not have happened such a long time ago, especially as we have no experimental evidence from that era to check our ideas against.
In Life Itself: Its Origin and Nature (1981), 88.
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Ants are so much like human beings as to be an embarrassment. They farm fungi, raise aphids as livestock, launch armies into wars, use chemical sprays to alarm and confuse enemies, capture slaves…. They exchange information ceaselessly. They do everything but watch television.
(1974) In 'On Societies as Organisms', A Long Line of Cells: Collected Essays (1990), 10.
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As crude a weapon as the cave man’s club, the chemical barrage has been hurled against the fabric of life—a fabric on the one hand delicate and destructible, on the other miraculously tough and resilient, and capable of striking back in unexpected ways. [On the effect of chemical insecticides and fertilizers.]
In Silent Spring, (1962), 297.
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As mineralogy constitutes a part of chemistry, it is clear that this arrangement [of minerals] must derive its principles from chemistry. The most perfect mode of arrangement would certainly be to allow bodies to follow each other according to the order of their electro-chemical properties, from the most electro-negative, oxygen, to the most electro-positive, potassium; and to place every compound body according to its most electro-positive ingredient.
An Attempt to Establish a Pure Scientific System of Mineralogy (1814), trans. J. Black, 48.
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As the Director of the Theoretical Division of Los Alamos, I participated at the most senior level in the World War II Manhattan Project that produced the first atomic weapons.
Now, at age 88, I am one of the few remaining such senior persons alive. Looking back at the half century since that time, I feel the most intense relief that these weapons have not been used since World War II, mixed with the horror that tens of thousands of such weapons have been built since that time—one hundred times more than any of us at Los Alamos could ever have imagined.
Today we are rightly in an era of disarmament and dismantlement of nuclear weapons. But in some countries nuclear weapons development still continues. Whether and when the various Nations of the World can agree to stop this is uncertain. But individual scientists can still influence this process by withholding their skills.
Accordingly, I call on all scientists in all countries to cease and desist from work creating, developing, improving and manufacturing further nuclear weapons - and, for that matter, other weapons of potential mass destruction such as chemical and biological weapons.
[On the occasion of the 50th Anniversary of Hiroshima.]
Letter, Bulletin of the Atomic Scientists (Nov 1995), 51:6, 3.
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At my urgent request the Curie laboratory, in which radium was discovered a short time ago, was shown to me. The Curies themselves were away travelling. It was a cross between a stable and a potato-cellar, and, if I had not seen the worktable with the chemical apparatus, I would have thought it a practical joke.
Wilhelm Ostwald on seeing the Curie's laboratory facilities.
In R. Reid, Marie Curie (1974), 95.
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At no period of [Michael Faraday’s] unmatched career was he interested in utility. He was absorbed in disentangling the riddles of the universe, at first chemical riddles, in later periods, physical riddles. As far as he cared, the question of utility was never raised. Any suspicion of utility would have restricted his restless curiosity. In the end, utility resulted, but it was never a criterion to which his ceaseless experimentation could be subjected.
'The Usefulness of Useless Knowledge', Harper's Magazine (Jun/Nov 1939), No. 179, 546. In Hispania (Feb 1944), 27, No. 1, 77.
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At present we begin to feel impatient, and to wish for a new state of chemical elements. For a time the desire was to add to the metals, now we wish to diminish their number. They increase upon us continually, and threaten to enclose within their ranks the bounds of our fair fields of chemical science. The rocks of the mountain and the soil of the plain, the sands of the sea and the salts that are in it, have given way to the powers we have been able to apply to them, but only to be replaced by metals.
In his 16th Lecture of 1818, in Bence Jones, The Life and Letters of Faraday (1870), Vol. 1, 256-257.
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At the moment I am occupied by an investigation with Kirchoff which does not allow us to sleep. Kirchoff has made a totally unexpected discovery, inasmuch as he has found out the cause for the dark lines in the solar spectrum and can produce these lines artificially intensified both in the solar spectrum and in the continuous spectrum of a flame, their position being identical with that of Fraunhofer’s lines. Hence the path is opened for the determination of the chemical composition of the Sun and the fixed stars.
Letter to H.E. Roscoe (Nov 1859). In The Life and Experiences of Sir Henry Enfield Roscoe (1906), 81.
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At the moment I am occupied by an investigation with Kirchoff which does not allow us to sleep. Kirchoff has made a totally unexpected discovery, inasmuch as he has found out the cause for the dark lines in the solar spectrum and can produce these lines artificially intensified both in the solar spectrum and in the continuous spectrum of a flame, their position being identical with that of Fraunhofer’s lines. Hence the path is opened for the determination of the chemical composition of the Sun and the fixed stars.
Letter to H.E. Roscoe (Nov 1859). In The Life and Experiences of Sir Henry Enfield Roscoe (1906), 71.
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At the present time it is of course quite customary for physicists to trespass on chemical ground, for mathematicians to do excellent work in physics, and for physicists to develop new mathematical procedures. … Trespassing is one of the most successful techniques in science.
In Dynamics in Psychology (1940, 1973), 116.
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Before the promulgation of the periodic law the chemical elements were mere fragmentary incidental facts in nature; there was no special reason to expect the discovery of new elements, and the new ones which were discovered from time to time appeared to be possessed of quite novel properties. The law of periodicity first enabled us to perceive undiscovered elements at a distance which formerly were inaccessible to chemical vision, and long ere they were discovered new elements appeared before our eyes possessed of a number of well-defined properties.
In Faraday Lecture, delivered before the Fellows of the Chemical Society in the Theatre of the Royal Institution (4 Jun 1889), printed in Professor Mendeléeff, 'The Periodic Law of the Chemical Elements', Transactions of the Chemical Society (1889), 55, 648.
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Biologists have long attempted by chemical means to induce in higher organisms predictable and specific changes which thereafter could be transmitted in series as hereditary characters. Among microorganisms the most striking example of inheritable and specific alterations in cell structure and function that can be experimentally induced and are reproducible under well defined and adequately controlled conditions is the transformation of specific types of Pneumococcus.
Oswald T. Avery (1877-1955), Colin Macleod (1909-72) and Maclyn McCarty (1911-2005), 'Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types', Journal of Experimental Medicine 1944, 79, 137.
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But nothing of a nature foreign to the duties of my profession [clergyman] engaged my attention while I was at Leeds so much as the, prosecution of my experiments relating to electricity, and especially the doctrine of air. The last I was led into a consequence of inhabiting a house adjoining to a public brewery, where first amused myself with making experiments on fixed air [carbon dioxide] which found ready made in the process of fermentation. When I removed from that house, I was under the necessity making the fixed air for myself; and one experiment leading to another, as I have distinctly and faithfully noted in my various publications on the subject, I by degrees contrived a convenient apparatus for the purpose, but of the cheapest kind. When I began these experiments I knew very little of chemistry, and had in a manner no idea on the subject before I attended a course of chymical lectures delivered in the Academy at Warrington by Dr. Turner of Liverpool. But I have often thought that upon the whole, this circumstance was no disadvantage to me; as in this situation I was led to devise an apparatus and processes of my own, adapted to my peculiar views. Whereas, if I had been previously accustomed to the usual chemical processes, I should not have so easily thought of any other; and without new modes of operation I should hardly have discovered anything materially new.
Memoirs of Dr. Joseph Priestley, in the Year 1795 (1806), Vol. 1, 61-2.
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By destroying the biological character of phenomena, the use of averages in physiology and medicine usually gives only apparent accuracy to the results. From our point of view, we may distinguish between several kinds of averages: physical averages, chemical averages and physiological and pathological averages. If, for instance, we observe the number of pulsations and the degree of blood pressure by means of the oscillations of a manometer throughout one day, and if we take the average of all our figures to get the true or average blood pressure and to learn the true or average number of pulsations, we shall simply have wrong numbers. In fact, the pulse decreases in number and intensity when we are fasting and increases during digestion or under different influences of movement and rest; all the biological characteristics of the phenomenon disappear in the average. Chemical averages are also often used. If we collect a man's urine during twenty-four hours and mix all this urine to analyze the average, we get an analysis of a urine which simply does not exist; for urine, when fasting, is different from urine during digestion. A startling instance of this kind was invented by a physiologist who took urine from a railroad station urinal where people of all nations passed, and who believed he could thus present an analysis of average European urine! Aside from physical and chemical, there are physiological averages, or what we might call average descriptions of phenomena, which are even more false. Let me assume that a physician collects a great many individual observations of a disease and that he makes an average description of symptoms observed in the individual cases; he will thus have a description that will never be matched in nature. So in physiology, we must never make average descriptions of experiments, because the true relations of phenomena disappear in the average; when dealing with complex and variable experiments, we must study their various circumstances, and then present our most perfect experiment as a type, which, however, still stands for true facts. In the cases just considered, averages must therefore be rejected, because they confuse, while aiming to unify, and distort while aiming to simplify. Averages are applicable only to reducing very slightly varying numerical data about clearly defined and absolutely simple cases.
From An Introduction to the Study of Experimental Medicine (1865), as translated by Henry Copley Greene (1957), 134-135.
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Rachel Carson quote: By their very nature chemical controls are self-defeating, for they have been devised and applied without t
By their very nature chemical controls are self-defeating, for they have been devised and applied without taking into account the complex biological systems against which they have been blindly hurled.
Silent Spring (1962), 246.
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Carbon has this genius of making a chemically stable two-dimensional, one-atom-thick membrane in a three-dimensional world. And that, I believe, is going to be very important in the future of chemistry and technology in general.
From Nobel Lecture (7 Dec 1996), 'Discovering the Fullerenes', collected in Ingmar Grenthe (ed.), Nobel Lectures, Chemistry 1996-2000 (2003).
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Cellular pathology is not an end if one cannot see any alteration in the cell. Chemistry brings the clarification of living processes nearer than does anatomy. Each anatomical change must have been preceded by a chemical one.
Attributed in H. Coper and H. Herken, Deutsche Medizini Wochenschrift (18 Oct 1963), 88, No. 42, 2035, in the original German, “Nach der Überlieferung durch His soll Virchow geäußert haben: ‘Die Zellular-pathologie ist nicht am Ende, wenn man an einer Zelle keine Veränderungen mehr sehen kann. Die Chemie steht der Erklärung der Lebensvorgänge näher als die Anatomie. Jede anatomische Verände-rung setzt notwendig eine chemische voraus.’” As translated in Angel Pentschew,'Morphology and morphogenesis of lead encephalopathy', Acta Neuropathologica (Sep 1965) 5, No. 2, 133-160, as cited in I. Arthur Michaelson and Mitchell W. Sauerhoff, 'Animal Models of Human Disease: Severe and Mild Lead Encephalopathy in the Neonatal Rat', Environmental Health Perspectives (May 1974), 7, 204 & 223 footnote. Note: Although given in quotation marks in the original German text, the subject quote is almost definitely NOT verbatim, but only a paraphrase of Virchow’s teachings. The German text introduces the subject quote with, “Nach der Überlieferung durch His soll Virchow geäußert haben:…” which means, “According to tradition Virchow is said to have expressed:…” (using Google translate). However, it is useful as a succinct statement to the effect of what Virchow might say to summarize his doctrine.
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Chemical analysis and synthesis go no farther than to the separation of particles one from another, and to their reunion. No new creation or destruction of matter is within the reach of chemical agency. We might as well attempt to introduce a new planet into the solar system, or to annihilate one already in existence, as to create or destroy a particle of hydrogen.
A New System of Chemical Philosophy (1808), Vol. 1, 212.
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Chemical biodynamics, involving as it does, the fusion of many scientific disciplines, … [played a role] in the elucidation of the carbon cycle. It can be expected to take an increasingly important place in the understanding of the dynamics of living organisms on a molecular level.
In Nobel Lecture (11 Dec 1961), 'The Path of Carbon in Photosynthesis', Nobel Lectures: Chemistry 1942-1962 (1964).
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Chemical engineering is the profession in which a knowledge of mathematics, chemistry and other natural sciences gained by study, experience and practice is applied with judgment to develop economic ways of using materials and energy for the benefit of mankind.
AIChE
In Article III, 'Definition of the Profession', Constitution of the American Institute of Chemical Engineers (as amended 17 Jan 2003). The same wording is found in the 1983 Constitution, as quoted in Nicholas A. Peppas (ed.), One Hundred Years of Chemical Engineering: From Lewis M. Norton (M.I.T. 1888) to Present (2012), 334.
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Chemical research conducts to the knowledge of philosophical truth, and forms the mind to philosophical enlargement and accuracy of thought, more happily than almost any other species of investigation in which the human intellect can be employed.
Quote following title page of Samuel Parkes, A Chemical Catechism With Notes, Illustrations and Experiments (8th ed. 1818).
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Chemical signs ought to be letters, for the greater facility of writing, and not to disfigure a printed book ... I shall take therefore for the chemical sign, the initial letter of the Latin name of each elementary substance: but as several have the same initial letter, I shall distinguish them in the following manner:— 1. In the class which I shall call metalloids, I shall employ the initial letter only, even when this letter is common to the metalloid and to some metal. 2. In the class of metals, I shall distinguish those that have the same initials with another metal, or a metalloid, by writing the first two letters of the word. 3. If the first two letters be common to two metals, I shall, in that case, add to the initial letter the first consonant which they have not in common: for example, S = sulphur, Si = silicium, St = stibium (antimony), Sn = stannum (tin), C = carbonicum, Co = colbaltum (colbalt), Cu = cuprum (copper), O = oxygen, Os = osmium, &c.
'Essay on the Cause of Chemical Proportions, and on some circumstances relating to them: together with a short and easy method of expressing them', Annals of Philosophy, 1814, 3,51-2.
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Chemical waste products are the droppings of science.
In 'On Science and Certainty', Discover Magazine (Oct 1980).
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Chemically induced hallucinations, delusions and raptures may be frightening or wonderfully gratifying; in either case they are in the nature of confidence tricks played on one’s own nervous system.
In 'Return Trip to Nirvana', Sunday Telegraph (12 Mar 1961), as collected in Kaleidoscope: Essays from Drinkers of Infinity, and The Heel of Achilles and Later Pieces and Stories (1981), 80 (source cited on p.72, footnote).
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Chemistry affords two general methods of determining the constituent principles of bodies, the method of analysis, and that of synthesis. When, for instance, by combining water with alkohol, we form the species of liquor called, in commercial language, brandy or spirit of wine, we certainly have a right to conclude, that brandy, or spirit of wine, is composed of alkohol combined with water. We can produce the same result by the analytical method; and in general it ought to be considered as a principle in chemical science, never to rest satisfied without both these species of proofs. We have this advantage in the analysis of atmospherical air, being able both to decompound it, and to form it a new in the most satisfactory manner.
Elements of Chemistry (1790), trans. R. Kerr, 33.
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Chemistry is the study of material transformations. Yet a knowledge of the rate, or time dependence, of chemical change is of critical importance for the successful synthesis of new materials and for the utilization of the energy generated by a reaction. During the past century it has become clear that all macroscopic chemical processes consist of many elementary chemical reactions that are themselves simply a series of encounters between atomic or molecular species. In order to understand the time dependence of chemical reactions, chemical kineticists have traditionally focused on sorting out all of the elementary chemical reactions involved in a macroscopic chemical process and determining their respective rates.
'Molecular Beam Studies of Elementary Chemical Processes', Nobel Lecture, 8 Dec 1986. In Nobel Lectures: Chemistry 1981-1990 (1992), 320.
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City after city, state after state, had essentially failed in their efforts to protect their air and their water, the land, the health of their citizens. By 1970, our city’ skylines were so polluted that in many places it was all but impossible to see from one city skyscraper to another. … We had rivers that were fouled with raw sewage and toxic chemicals. One actually caught on fire. There was a very famous photograph from my teenage years of the Cuyahoga River burning. In fact, it was memorialized in a song at the time.
In 'Environmental Protection: Meeting the Challenges of the Twenty-First Century', Harvard Environmental Law Review (2001), 25, 329, 330-331. [In fact, the Cuyahoga River had caught fire several times over a number of decades, and there had been fires on other rivers. Webmaster]
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Clinical ecology [is] a new branch of medicine aimed at helping people made sick by a failure to adapt to facets of our modern, polluted environment. Adverse reactions to processed foods and their chemical contaminants, and to indoor and outdoor air pollution with petrochemicals, are becoming more and more widespread and so far these reactions are being misdiagnosed by mainstream medical practitioners and so are not treated effectively.
Quoted in article 'Richard Mackarness', Contemporary Authors Online (2002).
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Considered from the standpoint of chemistry, living bodies appear to us as laboratories of chemical processes, for they undergo perpetual changes in their material substrate. They draw materials from the outside world and combine them with the mass of their liquid and solid parts.
In 'Allgemeine Betrachtungen der orgauischen Korper', Physiologie des Menschen (1830), Vol. 1, 34. Trans. in Kenneth L. Caneva, Robert Mayer and the Conservation of Energy (1993), 7I.
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CREATION OF LIFE.
The Startling Discovery of Prof. Loeb.
Lower Animals Produced by Chemical Means.
Process May Apply to the Human Species.
Immaculate Conception is Explained.
Wonderful Experiments Conducted at Woods Hole.
Newspaper
The Boston Herald (26 Nov 1899), 17.
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Dissection … teaches us that the body of man is made up of certain kinds of material, so differing from each other in optical and other physical characters and so built up together as to give the body certain structural features. Chemical examination further teaches us that these kinds of material are composed of various chemical substances, a large number of which have this characteristic that they possess a considerable amount of potential energy capable of being set free, rendered actual, by oxidation or some other chemical change. Thus the body as a whole may, from a chemical point of view, be considered as a mass of various chemical substances, representing altogether a considerable capital of potential energy.
From Introduction to A Text Book of Physiology (1876, 1891), Book 1, 1.
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Every breath you draw, every accelerated beat of your heart in the emotional periods of your oratory depend upon highly elaborated physical and chemical reactions and mechanisms which nature has been building up through a million centuries. If one of these mechanisms, which you owe entirely to your animal ancestry, were to be stopped for a single instant, you would fall lifeless on the stage. Not only this, but some of your highest ideals of human fellowship and comradeship were not created in a moment, but represent the work of ages.
Quoted in Closing Address by Dr. Henry Sloane Coffin, president of the Union Theological Seminary, New York, at the Memorial Service for Osborn at St. Bartholomew's Church, N.Y. (18 Dec 1935). In 'Henry Fairfield Osborn', Supplement to Natural History (Feb 1936), 37:2, 133-34. Bound in Kofoid Collection of Pamphlets on Biography, University of California.
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Every chemical substance, every plant, every animal in its growth, teaches the unity of the cause, the variety of appearance.
In 'History,' Essays: First Series (1841).
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Louis Pasteur quote: Every chemical substance, whether natural or artificial, falls into one of two major categories, according
Every chemical substance, whether natural or artificial, falls into one of two major categories, according to the spatial characteristic of its form. The distinction is between those substances that have a plane of symmetry and those that do not. The former belong to the mineral, the latter to the living world.
Pasteur Vallery-Radot (ed.), Oeuvres de Pasteur (1922-1939), Vol. I, 331. Quoted in Patrice Debré, Louis Pasteur, trans. Elborg Forster (1994), 261.
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Every living thing is a sort of imperialist, seeking to transform as much as possible of its environment into itself and its seed. When we compare the (present) human population of the globe with… that of former times, we see that “chemical imperialism” has been… the main end to which human intelligence has been devoted.
In 'Man and his Environment', An Outline of Philosophy (1927), 27.
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Experimental evidence is strongly in favor of my argument that the chemical purity of the air is of no importance.
Lecturer on Physiology at London Hospital, in 'Impure Air Not Unhealthful If Stirred and Cooled,' in The New York Times, September 22, 1912.
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Few scientists acquainted with the chemistry of biological systems at the molecular level can avoid being inspired. Evolution has produced chemical compounds exquisitely organized to accomplish the most complicated and delicate of tasks. Many organic chemists viewing crystal structures of enzyme systems or nucleic acids and knowing the marvels of specificity of the immune systems must dream of designing and synthesizing simpler organic compounds that imitate working features of these naturally occurring compounds.
In 'The Design of Molecular Hosts, Guests, and Their Complexes', Nobel Lecture, 8 December 1987. In Nobel Lectures: Chemistry 1981-1990 (1992), 419.
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Finally, to the theme of the respiratory chain, it is especially noteworthy that David Kellin's chemically simple view of the respiratory chain appears now to have been right all along–and he deserves great credit for having been so reluctant to become involved when the energy-rich chemical intermediates began to be so fashionable. This reminds me of the aphorism: 'The obscure we see eventually, the completely apparent takes longer'.
'David Kellin's Respiratory Chain Concept and Its Chemiosmotic Consequences', Nobel Lecture (8 Dec 1978). In Nobel Lectures: Chemistry 1971-1980 (1993), 325.
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First I would like to wash Bunsen, and then I would like to kiss him because he is such a charming man.
Remark by the wife of Emil Fischer, upon meeting Bunsen for the first time, perhaps noticing a lasting chemical odour from his work.
Quoted in E. Fischer, Aus meinem Leben (1923). Trans. W. H. Brock.
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Food is at present obtained almost entirely from the energy of the sunlight. The radiation from the sun produces from the carbonic acid in the air more or less complicated carbon compounds which serve us in plants and vegetables. We use the latent chemical energy of these to keep our bodies warm, we convert it into muscular effort. We employ it in the complicated process of digestion to repair and replace the wasted cells of our bodies. … If the gigantic sources of power become available, food would be produced without recourse to sunlight. Vast cellars, in which artificial radiation is generated, may replace the cornfields and potato patches of the world.
From 'Fifty Years Hence', Strand Magazine (Dec 1931). Reprinted in Popular Mechanics (Mar 1932), 57, No. 3, 396-397.
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For Christmas, 1939, a girl friend gave me a book token which I used to buy Linus Pauling's recently published Nature of the Chemical Bond. His book transformed the chemical flatland of my earlier textbooks into a world of three-dimensional structures.
'What Holds Molecules Together', in I Wish I'd Made You Angry Earlier (1998), 165.
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For the metaphysical term 'will' we may in these instances safely substitute the chemical term 'photochemical action of light.'
The Mechanistic Conception of Life (1912), 30.
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From the intensity of the spots near the centre, we can infer that the protein molecules are relatively dense globular bodies, perhaps joined together by valency bridges, but in any event separated by relatively large spaces which contain water. From the intensity of the more distant spots, it can be inferred that the arrangement of atoms inside the protein molecule is also of a perfectly definite kind, although without the periodicities characterising the fibrous proteins. The observations are compatible with oblate spheroidal molecules of diameters about 25 A. and 35 A., arranged in hexagonal screw-axis. ... At this stage, such ideas are merely speculative, but now that a crystalline protein has been made to give X-ray photographs, it is clear that we have the means of checking them and, by examining the structure of all crystalline proteins, arriving at a far more detailed conclusion about protein structure than previous physical or chemical methods have been able to give.
'X-Ray Photographs of Crystalline Pepsin', Nature (1934), 133, 795.
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Further study of the division phenomena requires a brief discussion of the material which thus far I have called the stainable substance of the nucleus. Since the term nuclear substance could easily result in misinterpretation..., I shall coin the term chromatin for the time being. This does not indicate that this substance must be a chemical compound of a definite composition, remaining the same in all nuclei. Although this may be the case, we simply do not know enough about the nuclear substances to make such an assumption. Therefore, we will designate as chromatin that substance, in the nucleus, which upon treatment with dyes known as nuclear stains does absorb the dye. From my description of the results of staining resting and dividing cells... it follows that the chromatin is distributed throughout the whole resting nucleus, mostly in the nucleoli, the network, and the membrane, but also in the ground-substance. In nuclear division it accumulates exclusively in the thread figures. The term achromatin suggests itself automatically for the unstainable substance of the nucleus. The terms chromatic and achromatic which will be used henceforth are thus explained.
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Genes make enzymes, and enzymes control the rates of chemical processes. Genes do not make ‘novelty seeking’ or any other complex and overt behavior. Predisposition via a long chain of complex chemical reactions, mediated through a more complex series of life’s circumstances, does not equal identification or even causation.
…...
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Graduates engaged in post-graduate work are reminded that their Supervisor is a University Officer and when visiting him officially in that capacity they should dress as they would in visiting any other officers of the University or of their own College (e.g. a tutor). Gowns, however, need not be worn in the chemical laboratory.
Note from Lennard-Jones to his PhD student, Charles Coulson, 14 Jul 1933. Quoted in S. C. Altham and E. J. Bowen, 'Charles Alfred Coulson 1910-1974', Biographical Memoirs of Fellows of the Royal Society (1974), 20, 78.
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HEART, n. An automatic, muscular blood- pump. Figuratively, this useful organ is said to be the seat of emotions and sentiments—a very pretty fancy which, however, is nothing but a survival of a once universal belief. It is now known that the sentiments and emotions reside in the stomach, being evolved from food by chemical action of the gastric fluid. The exact process by which a beefsteak becomes a feeling—tender or not, according to the age of the animal from which it was cut; the successive stages of elaboration through which a caviar sandwich is transmuted to a quaint fancy and reappears as a pungent epigram; the marvelous functional methods of converting a hard-boiled egg into religious contrition, or a cream-puff into a sigh of sensibility—these things have been patiently ascertained by M. Pasteur, and by him expounded with convincing lucidity. 
The Collected Works of Ambrose Bierce (1911), Vol. 7, The Devil's Dictionary,  133-134.
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Hemoglobin is one of the most interesting chemical substances in the world—to me it is the most interesting of all.
In 'The Hemoglobin Molecule in Health and Disease', read 19 Apr 1951, Proceedings of the American Philosophical Society (15 Oct 1952), 96, No. 5, 556.
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Here are a few things to keep in mind the next time ants show up in the potato salad. The 8,800 known species of the family Formicidae make up from 10% to 15% of the world's animal biomass, the total weight of all fauna. They are the most dominant social insect in the world, found almost everywhere except in the polar regions. Ants turn more soil than earthworms; they prune, weed and police most of the earth’s carrion. Among the most gregarious of creatures, they are equipped with a sophisticated chemical communications system. To appreciate the strength and speed of this pesky invertebrate, consider that a leaf cutter the size of a man could run repeated four-minute miles while carrying 750 lbs. of potato salad.
From book review, 'Nature: Splendor in The Grass', Time (3 Sep 1990).
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His motion to the meeting of the Council of the Chemical Society:
That henceforth the absurd game of chemical noughts and crosses be tabu within the Society's precincts and that, following the practice of the Press in ending a correspondence, it be an instruction to the officers to give notice “That no further contributions to the mysteries of Polarity will be received, considered or printed by the Society.” His challenge was not accepted.
From the personal and other items column of Chemistry and Industry (1925), 44, 1050.
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Historically [chemistry] arose from a constellation of interests: the empirically based technologies of early metallurgists, brewers, dyers, tanners, calciners and pharmacists; the speculative Greek philosphers' concern whether brute matter was invariant or transformable; the alchemists' real or symbolic attempts to achieve the transmutation of base metals into gold; and the iatrochemists' interst in the chemistry and pathology of animal and human functions. Partly because of the sheer complexity of chemical phenomena, the absence of criteria and standards of purity, and uncertainty over the definition of elements ... but above all because of the lack of a concept of the gaseous state of matter, chemistry remained a rambling, puzzling and chaotic area of natural philosophy until the middle of the eighteenth century.
The Chemical Tree: A History of Chemistry (2000), xxii.
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Hitherto the conception of chemical transmission at nerve endings and neuronal synapses, originating in Loewi’s discovery, and with the extension that the work of my colleagues has been able to give to it, can claim one practical result, in the specific, though alas only short, alleviation of the condition of myasthenia gravis, by eserine and its synthetic analogues.
'Some recent extensions of the chemical transmission of the effects of nerve impulses', Nobel Lecture, 12 December 1936. In Nobel Lectures: Physiology or Medicine 1922-1941 (1965), 412-3.
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Human blood is a testament to life’s origin in the ocean: its chemical composition is nearly identical to that of sea-water.
In 'Ocean Policy and Reasonable Utopias', The Forum (Summer 1981), 16, No. 5, 900.
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I am aware of some of the tragic repercussions of the chemical fight against insects taking place in France and elsewhere, and I deplore them. Modern man no longer knows how to foresee or to forestall. He will end by destroying the earth from which he and other living creatures draw their food. Poor bees, poor birds, poor men...
In Ann Cottrell Free (ed.), Animals, Nature and Albert Schweitzer (1982). Rachel Carson dedicated her book Silent Spring (1962) to Albert Schweitzer, with his words, “Modern man no longer knows how to foresee or to forestall. He will end by destroying the earth.”
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I do not know whether you are fond of chemical reading. There are some things in this science worth reading.
Letter to Mr. Rittenhouse (Paris, 1786). In Thomas Jefferson and John P. Foley (ed.), The Jeffersonian Cyclopedia (1900), 135. From H.A. Washington, The Writings of Thomas Jefferson (1853-54). Vol 1, 517.
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I found the invention was applicable to painting, and would also contribute to facilitate the study of geography: for I have applied it to some maps, the rivers of which I represented in silver, and in the cities in gold. The rivers appearing, as it were, in silver streams, have a most pleasing effect on the sight, and relieve the eye of that painful search for the course, and origin, of rivers, the minutest branches of which can be splendidly represented this way.
Description of an outcome of her experiments originally investigating 'the possibility of making cloths of gold, silver and other metals by chemical processes.'
Preface to An Essay on Combustion with a View to a New Art of Dyeing and Painting (1794), iii-iv. In Marilyn Bailey Ogilvie and Joy Dorothy Harvey, The Biographical Dictionary of Women in Science (2000), 478.
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I have always felt that I understood a phenomenon only to the extent that I could visualise it. Much of the charm organic chemical research has for me derives from structural formulae. When reading chemical journals, I look for formulae first.
From Design to Discovery (1990), 122.
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I have paid special attention to those Properties of the Positive Rays which seem to throw light on the problems of the structure of molecules and atoms and the question of chemical combination … I am convinced that as yet we are only at the beginning of the harvest of results which will elucidate the process of chemical combination, and thus bridge over the most serious gap which now exists between Physics and Chemistry.
Rays of Positive Electricity and their Application to Chemical Analyses (1921), v.
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I have recently read an article on handwriting and forgeries in which it is stated that ink eradicators do not remove ink: but merely bleach it, and that ink so bleached can be easily brought out by a process of fuming: known to all handwriting experts. Can you give me a description of this process, what chemicals are used: and how it is performed?
Showing his early interest in science, at age 16, while a student at Tulsa Central High School. From the first time Gardner’s writing appeared in print: a query printed in a magazine in Hugo Gernsback (ed.), 'Now It Is Now It Isn’t', Science and Invention (Apr 1930), 1119. As quoted and cited in Dana Richards, 'Martin Gardner: A “Documentary”', collected in Elwyn R. Berlekamp and Tom Rodgers (ed.) The Mathemagician and Pied Puzzler: A Collection in Tribute to Martin Gardner (1999), 3.
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I have taken up my lodgings in the loft of the laboratory building itself and am so quite at home with chemical apparatus and preparations all around, “they are congenial spirits,” as Mr. Silliman remarked when he showed me the room.
Letter to a friend (25 Jun 1845) as quoted by Frank Dawson Adams, in 'Biographical Memoir of Thomas Sterry Hunt' presented to the Annual Meeting of the National Academy of Sciences (1932). Hunt was Professor Silliman Jr’s student and assistant at the Scientific School of Yale University.
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I heard … xenon was a good anesthesia. … I thought, “How can xenon, which doesn’t form any chemical compounds, serve as a general anesthetic? … I lay awake at night for a few minutes before going to sleep, and during the next couple of weeks each night I would think, “…how do anesthetic agents work?" Then I forgot to do it after a while, but I’d trained my unconscious mind to keep this question alive and to call [it] to my consciousness whenever a new idea turned up…. So seven years went by. [One day I] put my feet up on the desk and started reading my mail, and here was a letter from George Jeffrey … an x-ray crystallographer, on his determination of the structure of a hydrate crystal. Immediately I sat up, took my feet off the desk, and said, “I understand anesthesia!” … I spent a year [and] determined the structure of chloroform hydrate, and then I wrote my paper published in June of 1961.
Interview with George B. Kauffman and Laurie M. Kauffman, in 'Linus Pauling: Reflections', American Scientist (Nov-Dec 1994), 82, No. 6, 522-523.
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I once had the honour of hearing the great molecular biologist Jacques Monod talking about creativity in science. I have forgotten his exact words, but he said approximately that, when trying to think through a chemical problem, he would ask himself what he would do if he were an electron.
In 'Introduction to the 30th Anniversary Edition', The Selfish Gene: 30th Anniversary Edition (1976, 2006), xi.
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I prefer the spagyric chemical physicians, for they do not consort with loafers or go about gorgeous in satins, silks and velvets, gold rings on their fingers, silver daggers hanging at their sides and white gloves on their hands, but they tend their work at the fire patiently day and night. They do not go promenading, but seek their recreation in the laboratory, wear plain learthern dress and aprons of hide upon which to wipe their hands, thrust their fingers amongst the coals, into dirt and rubbish and not into golden rings. They are sooty and dirty like the smiths and charcoal burners, and hence make little show, make not many words and gossip with their patients, do not highly praise their own remedies, for they well know that the work must praise the master, not the master praise his work. They well know that words and chatter do not help the sick nor cure them... Therefore they let such things alone and busy themselves with working with their fires and learning the steps of alchemy. These are distillation, solution, putrefaction, extraction, calcination, reverberation, sublimination, fixation, separation, reduction, coagulation, tinction, etc.
Quoted in R. Oesper, The Human Side of Scientists (1975), 150. [Spagyric is a form of herbalism based on alchemic procedures of preparation.]
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I purpose, in return for the honour you do us by coming to see what are our proceedings here, to bring before you, in the course of these lectures, the Chemical History of a Candle. I have taken this subject on a former occasion; and were it left to my own will, I should prefer to repeat it almost every year—so abundant is the interest that attaches itself to the subject, so wonderful are the varieties of outlet which it offers into the various departments of philosophy. There is not a law under which any part of this universe is governed which does not come into play, and is touched upon in these phenomena. There is no better, there is no more open door by which you can enter the study of natural philosophy, than by considering the physical phenomena of a candle.
A Course of Six Lectures on the Chemical History of a Candle (1861), 13-4.
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I shall never forget the sight. The vessel of crystallization was three quarters full of slightly muddy water—that is, dilute water-glass—and from the sandy bottom there strove upwards a grotesque little landscape of variously colored growths: a confused vegetation of blue, green, and brown shoots which reminded one of algae, mushrooms, attached polyps, also moss, then mussels, fruit pods, little trees or twigs from trees, here, and there of limbs. It was the most remarkable sight I ever saw, and remarkable not so much for its profoundly melancholy nature. For when Father Leverkühn asked us what we thought of it and we timidly answered him that they might be plants: “No,” he replied, “they are not, they only act that way. But do not think the less of them. Precisely because they do, because they try as hard as they can, they are worthy of all respect.”
It turned out that these growths were entirely unorganic in their origin; they existed by virtue of chemicals from the apothecary's shop.
Description of a “chemical garden” in Doktor Faustus: The Life of the German Composer Adrian Leverkühn, as Told by a Friend, (1947), 19.
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I think the facts leave no doubt that the very mightiest among the chemical forces are of electric origin. The atoms cling to their electric charges, and opposite electric charges cling to each other.
'On the Modern Development of Faraday's Conception of Electricity', Journal of the Chemical Society 1881, 39, 302.
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I was an impostor, the worthy associate of a brigand, &c., &c., and all this for an atom of chlorine put in the place of an atom of hydrogen, for the simple correction of a chemical formula!
Chemical Method (1855), 203.
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I will now direct the attention of scientists to a previously unnoticed cause which brings about the metamorphosis and decomposition phenomena which are usually called decay, putrefaction, rotting, fermentation and moldering. This cause is the ability possessed by a body engaged in decomposition or combination, i.e. in chemical action, to give rise in a body in contact with it the same ability to undergo the same change which it experiences itself.
Annalen der Pharmacie 1839, 30, 262. Trans. W. H. Brock.
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I would ... change the accepted rule that the nature of a complex molecule is determined by the nature, quantity, and position of its elementary component parts, by the following statement: the chemical nature of a complex molecule is determined by the nature of its elementary component parts, their quantity and chemical structure.
'On the Chemical Structure of Substances' 1861.
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I would like to emphasize strongly my belief that the era of computing chemists, when hundreds if not thousands of chemists will go to the computing machine instead of the laboratory for increasingly many facets of chemical information, is already at hand. There is only one obstacle, namely that someone must pay for the computing time.
'Spectroscopy, Molecular Orbitals, and Chemical Bonding', Nobel Lecture (12 Dec 1966). In Nobel Lectures: Chemistry 1963-1970 (1972), 159.
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I would like to start by emphasizing the importance of surfaces. It is at a surface where many of our most interesting and useful phenomena occur. We live for example on the surface of a planet. It is at a surface where the catalysis of chemical reactions occur. It is essentially at a surface of a plant that sunlight is converted to a sugar. In electronics, most if not all active circuit elements involve non-equilibrium phenomena occurring at surfaces. Much of biology is concerned with reactions at a surface.
'Surface properties of semiconductors', Nobel Lecture (11 Dec 1956). In Nobel Lectures, Physics 1942-1962 (1967), 377.
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I would not have it inferred ... that I am, as yet, an advocate for the hypothesis of chemical life. The doctrine of the vitality of the blood, stands in no need of aid from that speculative source. If it did, I would certainly abandon it. For, notwithstanding the fashionableness of the hypothesis in Europe, and the ascendancy it has gained over some minds in this country [USA], it will require stubborn facts to convince me that man with all his corporeal and intellectual attributes is nothing but hydro-phosphorated oxyde of azote ... When the chemist declares, that the same laws which direct the crystallization of spars, nitre and Glauber's salts, direct also the crystallization of man, he must pardon me if I neither understand him, nor believe him.
Medical Theses (1805), 391-2, footnote.
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If any spiritualistic medium can do stunts, there is no more need for special conditions than there is for a chemist to turn down lights, start operations with a hymn, and ask whether there's any chemical present that has affinity with something named Hydrogen.
Lo! (1932). In The Complete Books of Charles Fort (1975), 575.
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If Darwin were alive today the insect world would delight and astound him with its impressive verification of his theories of the survival of the fittest. Under the stress of intensive chemical spraying the weaker members of the insect populations are being weeded out… . Only the strong and fit remain to defy our efforts to control them.
In Silent Spring (1952, 1962), 263.
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If it be urged that the action of the potato is chemical and mechanical only, and that it is due to the chemical and mechanical effects of light and heat, the answer would seem to lie in an enquiry whether every sensation is not chemical and mechanical in its operation? Whether those things which we deem most purely spiritual are anything but disturbances of equilibrium in an infinite series of levers, beginning with those that are too small for microscopic detection, and going up to the human arm and the appliances which it makes use of? Whether there be not a molecular action of thought, whence a dynamical theory of the passions shall be deducible?
In Erewhon, Or, Over the Range (1872), 192.
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If it is good to teach students about the chemical industry then why is it not good to assign ethical qualities to substances along with their physical and chemical ones? We might for instance say that CS [gas] is a bad chemical because it can only ever be used by a few people with something to protect against many people with nothing to lose. Terylene or indigotin are neutral chemicals. Under capitalism their production is an exploitive process, under socialism they are used for the common good. Penicillin is a good chemical.
Quoted in T. Pateman (ed.), Countercourse (1972), 215.
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If materialism is true, it seems to me that we cannot know that it is true. If my opinions are the result of the chemical processes going on in my brain, they are determined by the laws of chemistry, not those of logic.
The Inequality of Man (1932), 162.
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If the results of the present study on the chemical nature of the transforming principle are confirmed, then nucleic acids must be regarded as possessing biological specificity the chemical basis of which is as yet undetermined.
Oswald T. Avery (1877-1955), Colin Macleod (1909-72) and Maclyn McCarty (1911-2005), ‘Studies in the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types', Journal of Experimental Medicine 1944, 79, 155.
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If there is no God, we are just molecules in motion, and we have no sense and no mind; we are just random firings of chemical in the brain. If our minds are composed only of physical matter, then our thoughts are, as Doug Wilson wittily quipped in his debate with atheist Dan Barker, just “brain gas.”
God Does Exist (2005), 45.
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If we assume that there is only one enzyme present to act as an oxidizing agent, we must assume for it as many different degrees of activity as are required to explain the occurrence of the various colors known to mendelize (three in mice, yellow, brown, and black). If we assume that a different enzyme or group of enzymes is responsible for the production of each pigment we must suppose that in mice at least three such enzymes or groups of enzymes exist. To determine which of these conditions occurs in mice is not a problem for the biologist, but for the chemist. The biologist must confine his attention to determining the number of distinct agencies at work in pigment formation irrespective of their chemical nature. These agencies, because of their physiological behavior, the biologist chooses to call 'factors,' and attempts to learn what he can about their functions in the evolution of color varieties.
Experimental Studies of the Inheritance of Color in Mice (1913), 17-18.
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If you know how to make chemical or electrical energy out of solar energy the way plants do it—without going through a heat engine—that is certainly a trick. And I’m sure we can do it. It’s just a question of how long it will take to solve the technical question.
As quoted in 'Melvin Calvin and Photosynthesis', Science Matters@Berkeley, 2, No. 11.
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In a certain sense I made a living for five or six years out of that one star [υ Sagittarii] and it is still a fascinating, not understood, star. It’s the first star in which you could clearly demonstrate an enormous difference in chemical composition from the sun. It had almost no hydrogen. It was made largely of helium, and had much too much nitrogen and neon. It’s still a mystery in many ways … But it was the first star ever analysed that had a different composition, and I started that area of spectroscopy in the late thirties.
Oral History Transcript of interview with Dr. Jesse Greenstein by Paul Wright (31 Jul 1974), on website of American Institute of Physics, about his research on strange shell stars. As quoted in J. B. Hearnshaw, The Analysis of Starlight: One Hundred and Fifty Years of Astronomical Spectroscopy (1986, 1990), 362. Hearnshaw footnoted that Berman earlier analysed the peculiar star R CrB (1935).
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In a manner of speaking, I can no longer hold my chemical water. I must tell you that I can make urea without the use of kidneys of any animal, be it man or dog. Ammonium cyanate is urea.
Letter from Wohler to Berzelius (22 Feb 1828). In O. Wallach (ed.), Briefwechsel zwischen J. Berzelius und F. Wohler (1901), Vol. 1, 206. Trans. W. H. Brock.
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In all chemical investigations, it has justly been considered an important object to ascertain the relative weights of the simples which constitute a compound. But unfortunately the enquiry has terminated here; whereas from the relative weights in the mass, the relative weights of the ultimate particles or atoms of the bodies might have been inferred, from which their number and weight in various other compounds would appear, in order to assist and to guide future investigations, and to correct their results. Now it is one great object of this work, to shew the importance and advantage of ascertaining the relative weights of the ultimate particles, both of simple and compound bodies, the number of simple elementary particles which constitute one compound particle, and the number of less compound particles which enter into the formation of one more compound particle.
If there are two bodies, A and B, which are disposed to combine, the following is the order in which the combinations may take place, beginning with the most simple: namely,
1 atom of A + 1 atom of B = 1 atom of C, binary
1 atom of A + 2 atoms of B = 1 atom of D, ternary
2 atoms of A + 1 atom of B = 1 atom of E, ternary
1 atom of A + 3 atoms of B = 1 atom of F, quaternary
3 atoms of A and 1 atom of B = 1 atom of G, quaternary
A New System of Chemical Philosophy (1808), Vol. 1, 212-3.
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In arranging the bodies in order of their electrical nature, there is formed an electro-chemical system which, in my opinion, is more fit than any other to give an idea of chemistry.
Essai sur le théorie des proportions chimiques (1819). Translated in Henry M. Leicester and Herbert S. Klickstein, A Source Book in Chemistry 1400-1900 (1952), 260.
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In describing a protein it is now common to distinguish the primary, secondary and tertiary structures. The primary structure is simply the order, or sequence, of the amino-acid residues along the polypeptide chains. This was first determined by Sanger using chemical techniques for the protein insulin, and has since been elucidated for a number of peptides and, in part, for one or two other small proteins. The secondary structure is the type of folding, coiling or puckering adopted by the polypeptide chain: the a-helix structure and the pleated sheet are examples. Secondary structure has been assigned in broad outline to a number of librous proteins such as silk, keratin and collagen; but we are ignorant of the nature of the secondary structure of any globular protein. True, there is suggestive evidence, though as yet no proof, that a-helices occur in globular proteins, to an extent which is difficult to gauge quantitatively in any particular case. The tertiary structure is the way in which the folded or coiled polypeptide chains are disposed to form the protein molecule as a three-dimensional object, in space. The chemical and physical properties of a protein cannot be fully interpreted until all three levels of structure are understood, for these properties depend on the spatial relationships between the amino-acids, and these in turn depend on the tertiary and secondary structures as much as on the primary. Only X-ray diffraction methods seem capable, even in principle, of unravelling the tertiary and secondary structures.
Co-author with G. Bodo, H. M. Dintzis, R. G. Parrish, H. Wyckoff, and D. C. Phillips
'A Three-Dimensional Model of the Myoglobin Molecule Obtained by X-ray Analysis', Nature (1958) 181, 662.
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In early life I had felt a strong desire to devote myself to the experimental study of nature; and, happening to see a glass containing some camphor, portions of which had been caused to condense in very beautiful crystals on the illuminated side, I was induced to read everything I could obtain respecting the chemical and mechanical influences of light, adhesion, and capillary attraction.
In preface to Scientific Memoirs (1878), xii.
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In my first publication I might have claimed that I had come to the conclusion, as a result of serious study of the literature and deep thought, that valuable antibacterial substances were made by moulds and that I set out to investigate the problem. That would have been untrue and I preferred to tell the truth that penicillin started as a chance observation. My only merit is that I did not neglect the observation and that I pursued the subject as a bacteriologist. My publication in 1929 was the starting-point of the work of others who developed penicillin especially in the chemical field.
'Penicillin', Nobel Lecture, 11 Dec 1945. In Nobel Lectures: Physiology or Medicine 1942-1962 (1964), 83.
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In order to pursue chemotherapy successfully we must look for substances which possess a high affinity and high lethal potency in relation to the parasites, but have a low toxicity in relation to the body, so that it becomes possible to kill the parasites without damaging the body to any great extent. We want to hit the parasites as selectively as possible. In other words, we must learn to aim and to aim in a chemical sense. The way to do this is to synthesize by chemical means as many derivatives as possible of relevant substances.
'Ueber den jetzigen Stand der Chemotherapie'. Berichte der Deutschen Chemischen Gesellschagt, 1909, 42, 17-47. Translated in B. Holmstedt and G. Liljestrand (eds.), Readings in Pharmacology (1963), 286.
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In the case of chemical investigations known as decompositions or analyses, it is first important to determine exactly what ingredients you are dealing with, or chemically speaking, what substances are contained in a given mixture or composite. For this purpose we use reagents, i.e., substances that possess certain properties and characteristics, which we well know from references or personal experience, such that the changes which they bring about or undergo, so to say the language that they speak thereby inform the researcher that this or that specific substance is present in the mixture in question.
From Zur Farben-Chemie Musterbilder für Freunde des Schönen und zum Gebrauch für Zeichner, Maler, Verzierer und Zeugdrucker [On Colour Chemistry...] (1850), Introduction. Translation tweaked by Webmaster from version in Herbert and W. Roesky and Klaud Möckel, translated by T.N. Mitchell and W.E. Russey, Chemical Curiosities: Spectacular Experiments and Inspired Quotes (1996), 1. From the original German, “Bei solchen chemischen Untersuchungen, die man zersetzende oder zergliedernde nennt, kommt es zunächst darauf an, zu ermitteln, mit welchen Stoffen man es zu thun hat, oder um chemisch zu reden, welche Stoffe in einem bestimmten Gemenge oder Gemisch enthalten sind. Hierzu bedient man sich sogenannter gegenwirkender Mittel, d. h. Stoffe, die bestimmte Eigenschaften und Eigenthümlichkeiten besitzen und die man aus Ueberlieferung oder eigner Erfahrung genau kennt, so daß die Veränderungen, welche sie bewirken oder erleiden, gleichsam die Sprache sind, mit der sie reden und dadurch dem Forscher anzeigen, daß der und der bestimmte Stoff in der fraglichen Mischung enthalten sei.”
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In the present state of our knowledge, it would be useless to attempt to speculate on the remote cause of the electrical energy, or the reason why different bodies, after being brought into contact, should be found differently electrified; its relation to chemical affinity is, however, sufficiently evident. May it not be identical with it, and an essential property of matter?
Bakerian Lecture, 'On Some Chemical Agencies of Electricity', Philosophical Transactions of the Royal Society, 1807, 97, 39.
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In the vestibule of the Manchester Town Hall are placed two life-sized marble statues facing each other. One of these is that of John Dalton … the other that of James Prescott Joule. … Thus honour is done to Manchester’s two greatest sons—to Dalton, the founder of modern Chemistry and of the Atomic Theory, and the laws of chemical-combining proportions; to Joule, the founder of modern Physics and the discoverer of the Law of Conservation of Energy. The one gave to the world the final and satisfactory proof … that in every kind of chemical change no loss of matter occurs; the other proved that in all the varied modes of physical change, no loss of energy takes place.
In John Dalton and the Rise of Modern Chemistry (1895), 7.
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Incandescent carbon particles, by the tens of millions, leap free of the log and wave like banners, as flame. Several hundred significantly different chemical reactions are now going on. For example, a carbon atom and four hydrogen atoms, coming out of the breaking cellulose, may lock together and form methane, natural gas. The methane, burning (combining with oxygen), turns into carbon dioxide and water, which also go up the flue. If two carbon atoms happen to come out of the wood with six hydrogen atoms, they are, agglomerately, ethane, which bums to become, also, carbon dioxide and water. Three carbons and eight hydrogens form propane, and propane is there, too, in the fire. Four carbons and ten hydrogens—butane. Five carbons … pentane. Six … hexane. Seven … heptane. Eight carbons and eighteen hydrogens—octane. All these compounds come away in the breaking of the cellulose molecule, and burn, and go up the chimney as carbon dioxide and water. Pentane, hexane, heptane, and octane have a collective name. Logs burning in a fireplace are making and burning gasoline.
In 'Firewood', Pieces of the Frame (1975), 205-206.
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Is it not true that the doctrine of attraction and gravity has done nothing but astonish our imagination? Is it not true that all chemical discoveries have done only the same?
Letter to Jean le Rond D'Alembert (7 Jan 1768). Collected in Correspondence: Letters Between Frederick II and M. D’Alembert (1789), 79, as translated by Thomas Holcroft.
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It is a very strange thing to reflect that but for the invention of Professor Haber the Germans could not have continued the War after their original stack of nitrates was exhausted. The invention of this single man has enabled them, utilising the interval in which their accumulations were used up, not only to maintain an almost unlimited supply of explosives for all purposes, but to provide amply for the needs of agriculture in chemical manures. It is a remarkable fact, and shows on what obscure and accidental incidents the fortunes of possible the whole world may turn in these days of scientific discovery.
[During World War I, Fritz Haber and Karl Bosch invented a large scale process to cause the direct combination of hydrogen and nitrogen gases to chemically synthesize ammonia, thus providing a replacement for sodium nitrate in the manufacture of explosives and fertilizers.]
Parliamentary debate (25 Apr 1918). In Winston Churchill, Richard Langworth (ed.), Churchill by Himself: The Definitive Collection of Quotations (2008), 469. by Winston Churchill, Richard Langworth
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It is now widely realized that nearly all the “classical” problems of molecular biology have either been solved or will be solved in the next decade. The entry of large numbers of American and other biochemists into the field will ensure that all the chemical details of replication and transcription will be elucidated. Because of this, I have long felt that the future of molecular biology lies in the extension of research to other fields of biology, notably development and the nervous system.
Letter to Max Perua, 5 June 1963. Quoted in William B. Wood (ed.), The Nematode Caenorhabditis Elegans (1988), x-xi.
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It is only those who know a little of nature, who fancy they know much. I have heard a young man say, after hearing a few popular chemical lectures, and seeing a few bottle and squirt experiments: Oh, water—water is only oxygen and hydrogen!—as if he knew all about it. While the true chemist would smile sadly enough at the the youth's hasty conceit, and say in his heart: 'Well, he is a lucky fellow.'
'Thoughts in a Gravel Pit', a lecture delivered at the Mechanics' Institute, Odiham (1857). The Works of Charles Kingsley (1880), 284.
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It is structure that we look for whenever we try to understand anything. All science is built upon this search; we investigate how the cell is built of reticular material, cytoplasm, chromosomes; how crystals aggregate; how atoms are fastened together; how electrons constitute a chemical bond between atoms. We like to understand, and to explain, observed facts in terms of structure. A chemist who understands why a diamond has certain properties, or why nylon or hemoglobin have other properties, because of the different ways their atoms are arranged, may ask questions that a geologist would not think of formulating, unless he had been similarly trained in this way of thinking about the world.
‘The Place of Chemistry In the Integration of the Sciences’, Main Currents in Modern Thought (1950), 7, 110.
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It is the destiny of wine to be drunk, and it is the destiny of glucose to be oxidized. But it was not oxidized immediately: its drinker kept it in his liver for more than a week, well curled up and tranquil, as a reserve aliment for a sudden effort; an effort that he was forced to make the following Sunday, pursuing a bolting horse. Farewell to the hexagonal structure: in the space of a few instants the skein was unwound and became glucose again, and this was dragged by the bloodstream all the way to a minute muscle fiber in the thigh, and here brutally split into two molecules of lactic acid, the grim harbinger of fatigue: only later, some minutes after, the panting of the lungs was able to supply the oxygen necessary to quietly oxidize the latter. So a new molecule of carbon dioxide returned to the atmosphere, and a parcel of the energy that the sun had handed to the vine-shoot passed from the state of chemical energy to that of mechanical energy, and thereafter settled down in the slothful condition of heat, warming up imperceptibly the air moved by the running and the blood of the runner. 'Such is life,' although rarely is it described in this manner: an inserting itself, a drawing off to its advantage, a parasitizing of the downward course of energy, from its noble solar form to the degraded one of low-temperature heat. In this downward course, which leads to equilibrium and thus death, life draws a bend and nests in it.
The Periodic Table (1975), trans. Raymond Rosenthal (1984), 192-3.
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It is usually not recognized that for every injurious or parasitic microbe there are dozens of beneficial ones. Without the latter, there would be no bread to eat nor wine to drink, no fertile soils and no potable waters, no clothing and no sanitation. One can visualize no form of higher life without the existence of the microbes. They are the universal scavengers. They keep in constant circulation the chemical elements which are so essential to the continuation of plant and animal life.
In My Life With the Microbes (1954), 4.
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It seems to me that the view toward which we are tending is that the specificity in gene action is always a chemical specificity, probably the production of enzymes which guide metabolic processes along particular channels. A given array of genes thus determines the production of a particular kind of protoplasm with particular properties—such, for example, as that of responding to surface forces by the formation of a special sort of semipermeable membrane, and that of responding to trivial asymmetries in the play of external stimuli by polarization, with consequent orderly quantitative gradients in all physiologic processes. Different genes may now be called into play at different points in this simple pattern, either through the local formation of their specific substrates for action, or by activation of a mutational nature. In either case the pattern becomes more complex and qualitatively differentiated. Successive interactions of differentiated regions and the calling into play of additional genes may lead to any degree of complexity of pattern in the organism as a largely self-contained system. The array of genes, assembled in the course of evolution, must of course be one which determines a highly self­regulatory system of reactions. On this view the genes are highly specific chemically, and thus called into play only under very specific conditions; but their morphological effects, if any, rest on quantitative influences of immediate or remote products on growth gradients, which are resultants of all that has gone on before in the organism.
In 'Genetics of Abnormal Growth in the Guinea Pig', Cold Spring Harbor Symposia on Quantitative Biology (1934), 2, 142.
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It was obvious—to me at any rate—that the answer was to why an enzyme is able to speed up a chemical reaction by as much as 10 million times. It had to do this by lowering the energy of activation—the energy of forming the activated complex. It could do this by forming strong bonds with the activated complex, but only weak bonds with the reactants or products.
Quoted In Thomas Hager, Force of Nature: The Life of Linus Pauling (1995), 284.
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Just as the arts of tanning and dyeing were practiced long before the scientific principles upon which they depend were known, so also the practice of Chemical Engineering preceded any analysis or exposition of the principles upon which such practice is based.
In William H. Walker, Warren K. Lewis and William H. MacAdams, The Principles of Chemical Engineering (1923), Preface to 1st. edition, v.
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Just think of the differences today. A young person gets interested in chemistry and is given a chemical set. But it doesn't contain potassium cyanide. It doesn't even contain copper sulfate or anything else interesting because all the interesting chemicals are considered dangerous substances. Therefore, these budding young chemists don't get a chance to do anything engrossing with their chemistry sets. As I look back, I think it is pretty remarkable that Mr. Ziegler, this friend of the family, would have so easily turned over one-third of an ounce of potassium cyanide to me, an eleven-year-old boy.
In Barbara Marinacci, Linus Pauling In His Own Words (1995), 29.
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Liebig was not a teacher in the ordinary sense of the word. Scientifically productive himself in an unusual degree, and rich in chemical ideas, he imparted the latter to his advanced pupils, to be put by them to experimental proof; he thus brought his pupils gradually to think for themselves, besides showing and explaining to them the methods by which chemical problems might be solved experimentally.
As quoted in G. H. Getman, The Life of Ira Remsen (1980), 18-19.
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Life is order, death is disorder. A fundamental law of Nature states that spontaneous chemical changes in the universe tend toward chaos. But life has, during milliards of years of evolution, seemingly contradicted this law. With the aid of energy derived from the sun it has built up the most complicated systems to be found in the universe—living organisms. Living matter is characterized by a high degree of chemical organisation on all levels, from the organs of large organisms to the smallest constituents of the cell. The beauty we experience when we enjoy the exquisite form of a flower or a bird is a reflection of a microscopic beauty in the architecture of molecules.
The Nobel Prize for Chemistry: Introductory Address'. Nobel Lectures: Chemistry 1981-1990 (1992), 69.
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Life itself is but the expression of a sum of phenomena, each of which follows the ordinary physical and chemical laws. (1845)
In Jonathan Miller, Freud: the Man, his World, His Influence (1972), 25
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Like thousands of other boys, I had a little chemical laboratory in our cellar and think that some of our friends thought me a bit crazy.
Quoted in 'Langmuir Winner Stumped Einstein”, New York Times (23 Aug 1931), N2.
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Man, some modern philosophers tell us, is alienated from his world: he is a stranger and afraid in a world he never made. Perhaps he is; yet so are animals, and even plants. They too were born, long ago, into a physico-chemical world, a world they never made.
'A Realist View of Logic Physics', in Wolfgang Yourgrau, et al., Physics, Logic, and History: based on the First International Colloquium held at the University of Denver, May 16-20, 1966 (1970), 1.
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Melvin Calvin was a fearless scientist, totally unafraid to venture into new fields such as hot atom chemistry, carcinogenesis, chemical evolution and the origin of life, organic geochemistry, immunochemistry, petroleum production from plants, farming, Moon rock analysis, and development of novel synthetic biomembrane models for plant photosystems.
Co-author with Andrew A. Benson, 'Melvin Calvin', Biographical Memoirs of the US National Academy of Science.
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Mr. Dalton's aspect and manner were repulsive. There was no gracefulness belonging to him. His voice was harsh and brawling; his gait stiff and awkward; his style of writing and conversation dry and almost crabbed. In person he was tall, bony, and slender. He never could learn to swim: on investigating this circumstance he found that his spec. grav. as a mass was greater than that of water; and he mentioned this in his lectures on natural philosophy in illustration of the capability of different persons for attaining the art of swimming. Independence and simplicity of manner and originality were his best qualities. Though in comparatively humble circumstances he maintained the dignity of the philosophical character. As the first distinct promulgator of the doctrine that the elements of bodies unite in definite proportions to form chemical compounds, he has acquired an undying fame.
Dr John Davy's (brother of Humphry Davy) impressions of Dalton written in c.1830-31 in Malta.
John Davy
Quoted in W. C. Henry, Memoirs of the Life and Scientific Researches of John Dalton (1854), 217-8.
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My ambition was to bring to bear on medicine a chemical approach. I did that by chemical manipulation of viruses and chemical ways of thinking in biomedical research.
From interview (1980) quoted in New York Times (24 Jun 1995), 9.
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My experiments proved that the radiation of uranium compounds ... is an atomic property of the element of uranium. Its intensity is proportional to the quantity of uranium contained in the compound, and depends neither on conditions of chemical combination, nor on external circumstances, such as light or temperature.
... The radiation of thorium has an intensity of the same order as that of uranium, and is, as in the case of uranium, an atomic property of the element.
It was necessary at this point to find a new term to define this new property of matter manifested by the elements of uranium and thorium. I proposed the word radioactivity which has since become generally adopted; the radioactive elements have been called radio elements.
In Pierre Curie, with the Autobiographical Notes of Marie Curie, trans. Charlotte and Vernon Kellogg (1923), 96. Also in reprint (2012) 45-46.
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My main thesis will be that in the study of the intermediate processes of metabolism we have to deal not with complex substances which elude ordinary chemical methods, but with the simple substances undergoing comprehensible reactions... I intend also to emphasise the fact that it is not alone with the separation and identification of products from the animal that our present studies deal; but with their reactions in the body; with the dynamic side of biochemical phenomena.
'The Dynamic Side of Biochemistry', Address (11 Sep 1913) in Report on the 83rd Meeting of the British Association for the Advancement of Science (1914), 653.
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My position is perfectly definite. Gravitation, motion, heat, light, electricity and chemical action are one and the same object in various forms of manifestation.
Annalen der Chemie und der Pharmacie (1842). Trans. A. S. Eve and C. H. Creasey, The Life and Work of John Tyndall (1945), 94.
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My present and most fixed opinion regarding the nature of alcoholic fermentation is this: The chemical act of fermentation is essentially a phenomenon correlative with a vital act, beginning and ending with the latter. I believe that there is never any alcoholic fermentation without their being simultaneously the organization, development, multiplication of the globules, or the pursued, continued life of globules which are already formed.
In 'Memoire sur la fermentation alcoolique', Annales de Chemie et de Physique (1860), 58:3, 359-360, as translated in Joseph S. Fruton, Proteins, Enzymes, Genes: The Interplay of Chemistry and Biology (1999), 137.
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Nature has put itself the problem how to catch in flight light streaming to the earth and to store the most elusive of all powers in rigid form. To achieve this aim, it has covered the crust of earth with organisms which in their life processes absorb the light of the sun and use this power to produce a continuously accumulating chemical difference. ... The plants take in one form of power, light; and produce another power, chemical difference.
In pamphlet, The Organic Motion in its Relation to Metabolism (1845), as translated in Eugene Rabinowitch, Govindjee, Photosynthesis (1969), 9.
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Nature, everywhere the most amazingly and outstandingly remarkable producer of living bodies, being most carefully arranged according to physical, mechanical, and chemical laws, does not give even the smallest hint of its extraordinary and tireless workings and quite clearly points to its work as being alone worthy of a benign and omnipotent God; and it carries this bright quality in all of its traces, in that, just as all of its general mechanisms rejoice, so also do all of their various smallest component parts rejoice in the depth of wisdom, in the height of perfection, and in the lofty arrangement of forms and qualities, which lie far beyond every investigation of the human mind.
'Inaugural Physico-Medical Dissertation on the Blood and the Circulation of the Microcosm' (1749). Trans. Arthur Donovan and Joseph Prentiss, James Hutton's Medical Dissertation (1980), 29.
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Nobody, I suppose, could devote many years to the study of chemical kinetics without being deeply conscious of the fascination of time and change: this is something that goes outside science into poetry; but science, subject to the rigid necessity of always seeking closer approximations to the truth, itself contains many poetical elements.
From Nobel Lecture (11 Dec 1956), collected in Nobel Lectures in Chemistry (1999), 474.
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Nor can it be supposed that the diversity of chemical structure and process stops at the boundary of the species, and that within that boundary, which has no real finality, rigid uniformity reigns. Such a conception is at variance with any evolutionary conception of the nature and origin of species. The existence of chemical individuality follows of necessity from that of chemical specificity, but we should expect the differences between individuals to be still more subtle and difficult of detection. Indications of their existence are seen, even in man, in the various tints of skin, hair, and eyes, and in the quantitative differences in those portions of the end-products of metabolism which are endogenous and are not affected by diet, such as recent researches have revealed in increasing numbers. Even those idiosyncrasies with regard to drugs and articles of food which are summed up in the proverbial saying that what is one man's meat is another man's poison presumably have a chemical basis.
Inborn Errors of Metabolism: The Croonian Lectures delivered before the Royal College of Physicians of London, in June, 1908 (1909), 2-3.
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Now if we want poets to interpret physical science as Milton and Shelley did (Shelley and Keats were the last English poets who were at all up-to-date in their chemical knowledge), we must see that our possible poets are instructed, as their masters were, in science and economics.
In Daedalus or Science and the Future (1924). Reprinted in Haldane's Daedalus Revisited (1995), 31.
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Now that we locate them [genes] in the chromosomes are we justified in regarding them as material units; as chemical bodies of a higher order than molecules? Frankly, these are questions with which the working geneticist has not much concern himself, except now and then to speculate as to the nature of the postulated elements. There is no consensus of opinion amongst geneticists as to what the genes are—whether they are real or purely fictitious—because at the level at which the genetic experiments lie, it does not make the slightest difference whether the gene is a hypothetical unit, or whether the gene is a material particle. In either case the unit is associated with a specific chromosome, and can be localized there by purely genetic analysis. Hence, if the gene is a material unit, it is a piece of chromosome; if it is a fictitious unit, it must be referred to a definite location in a chromosome—the same place as on the other hypothesis. Therefore, it makes no difference in the actual work in genetics which point of view is taken. Between the characters that are used by the geneticist and the genes that his theory postulates lies the whole field of embryonic development.
'The Relation of Genetics to Physiology and Medicine', Nobel Lecture (4 Jun 1934). In Nobel Lectures, Physiology or Medicine 1922-1941 (1965), 315.
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Once a molecule is asymmetric, its extension proceeds also in an asymmetrical sense. This concept completely eliminates the difference between natural and artificial synthesis. The advance of science has removed the last chemical hiding place for the once so highly esteemed vis vitalis.
‘Synthesen in der Zuckergruppe', Berichte der deutschen Chemischen Gesellschaft, 1894, 27, 3189.
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One can claim that chemical engineering was practiced even by the ancient Greeks and Romans when they were making soap or wine, or treating ores in Lavrion or Sicily.
In 'The Origins of Academic Chemical Engineering', collected in Nicholas A. Peppas, One Hundred Years of Chemical Engineering: From Lewis M. Norton (M.I.T. 1888) to Present (2012), 1.
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One day we shall certainly 'reduce' thought experimentally to molecular and chemical motions in the brain; but does that exhaust the essence of thought?
Dialectics of Nature (1925), trans. Clemens Dutt (1940), 175.
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One important object of this original spectroscopic investigation of the light of the stars and other celestial bodies, namely to discover whether the same chemical elements as those of our earth are present throughout the universe, was most satisfactorily settled in the affirmative. (1909)
In Publications of Sir William Huggins's Observatory (1909), Vol. 2, 49, footnote added to emphasize the significance of the results shown in this collection’s reprint of William Huggins and Dr. Miller, 'On the Spectra of Some of the Fixed Stars', Philosophical Transactions (1864), 64, 413-435.
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One of the great triumphs of 20th Century astrophysics, was tracing the elements of your body, of all the elements around us, to the actions of stars—that crucible in the centers of stars that cooked basic elements into heavier elements, light elements into heavy elements. (I say “cooked”—I mean thermonuclear fusion.) The heat brings them together, gets you bigger atoms, that then do other interesting chemical things, fleshing out the contents of the Periodic Table.
From interview, The Science Studio video series of The Science Network website, episode 'The Moon, the Tides and why Neil DeGrasse Tyson is Colbert’s God' (20 Jan 2011), time 20:53-21:25.
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One of the most immediate consequences of the electrochemical theory is the necessity of regarding all chemical compounds as binary substances. It is necessary to discover in each of them the positive and negative constituents... No view was ever more fitted to retard the progress of organic chemistry. Where the theory of substitution and the theory of types assume similar molecules, in which some of the elements can be replaced by others without the edifice becoming modified either in form or outward behaviour, the electrochemical theory divides these same molecules, simply and solely, it may be said, in order to find in them two opposite groups, which it then supposes to be combined with each other in virtue of their mutual electrical activity... I have tried to show that in organic chemistry there exist types which are capable, without destruction, of undergoing the most singular transformations according to the nature of the elements.
Traité de Chemie Appliquée aux Arts, Vol. I (1828), 53. Trans. J. R. Partington, A History of Chemistry, Vol. 4, 366.
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One or two atoms can convert a fuel to a poison, change a color, render an inedible substance edible, or replace a pungent odor with a fragrant one. That changing a single atom can have such consequences is the wonder of the chemical world.
In Scientific American Library, Molecules (1987), 2.
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One reason which has led the organic chemist to avert his mind from the problems of Biochemistry is the obsession that the really significant happenings in the animal body are concerned in the main with substances of such high molecular weight and consequent vagueness of molecular structure as to make their reactions impossible of study by his available and accurate methods. There remains, I find, pretty widely spread, the feeling—due to earlier biological teaching—that, apart from substances which are obviously excreta, all the simpler products which can be found in cells or tissues are as a class mere objects, already too remote from the fundamental biochemical events to have much significance. So far from this being the case, recent progress points in the clearest way to the fact that the molecules with which a most important and significant part of the chemical dynamics of living tissues is concerned are of a comparatively simple character.
In 'The Dynamic Side of Biochemistry', Address (11 Sep 1913) in Report on the 83rd Meeting of the British Association for the Advancement of Science (1914), 657-8.
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One word characterises the most strenuous of the efforts for the advancement of science that I have made perseveringly during fifty-five years; that word is failure. I know no more of electric and magnetic force, or of the relation between ether, electricity and ponderable matter, or of chemical affinity, than I knew and tried to teach to my students of natural philosophy fifty years ago in my first session as Professor.
Address (16 Jun 1896), at Celebration for his Jubilee as Professor, at Glasgow University. Printed in The Electrician (19 Jun 1896), 37, 247.
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Pauling was shocked by the freedom with which the X-ray crystallographers of the time, including particularly Astbury, played with the intimate chemical structure of their models. They seemed to think that if the atoms were arranged in the right order and about the right distance apart, that was all that mattered, that no further restrictions need to be put on them.
Quoted by John Law in 'The Case of X-ray Protein Crystallography', collected in Gerard Lemaine (ed.), Perspectives on the Emergence of Scientific Disciplines, 1976, 140.
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Perhaps... some day the precision of the data will be brought so far that the mathematician will be able to calculate at his desk the outcome of any chemical combination, in the same way, so to speak, as he calculates the motions of celestial bodies.
Oeuvres (1862), Vol. 2, 550-1. Trans. John Heilbron, Weighing Imponderables and Other Quantitative Science around 1800 (1993), 14.
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Physical changes take place continuously, while chemical changes take place discontinuously. Physics deals chiefly with continuous varying quantities, while chemistry deals chiefly with whole numbers.
Treatise on Thermodynamics (1897), trans. Alexander Ogg (1903), 22, footnote.
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Populations of bacteria live in the spumes of volcanic thermal vents on the ocean floor, multiplying in water above the boiling point. And far beneath Earth’s surface, to a depth of 2 miles (3.2 km) or more, dwell the SLIMES (subsurface lithoautotrophic microbial ecosystems), unique assemblages of bacteria and fungi that occupy pores in the interlocking mineral grains of igneous rock and derive their energy from inorganic chemicals. The SLIMES are independent of the world above, so even if all of it were burned to a cinder, they would carry on and, given enough time, probably evolve new life-forms able to re-enter the world of air and sunlight.
In 'Vanishing Before Our Eyes', Time (26 Apr 2000).
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Primates stand at a turning point in the course of evolution. Primates are to the biologist what viruses are to the biochemist. They can be analysed and partly understood according to the rules of a simpler discipline, but they also present another level of complexity: viruses are living chemicals, and primates are animals who love and hate and think.
'The Evolution of Primate Behavior: A survey of the primate order traces the progressive development of intelligence as a way of life', American Scientist (1985), 73, 288.
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Professor, how can you bring yourself to enter this chemical building that has Ionic columns?
[Kahlenberg, a physical chemist, was an opponent of ionic theory.]
Quoted in Ralph Oesper, The Human Side of Scientists (1975), 106.
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Scheele, it was said, never forgot anything if it had to do with chemistry. He never forgot the look, the feel, the smell of a substance, or the way it was transformed in chemical reactions, never forgot anything he read, or was told, about the phenomena of chemistry. He seemed indifferent, or inattentive, to most things else, being wholly dedicated to his single passion, chemistry. It was this pure and passionate absorption in phenomena—noticing everything, forgetting nothing—that constituted Scheele's special strength.
Uncle Tungsten: Memories of a Chemical Boyhood (2001), 44.
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Science has thus, most unexpectedly, placed in our hands a new power of great but unknown energy. It does not wake the winds from their caverns; nor give wings to water by the urgency of heat; nor drive to exhaustion the muscular power of animals; nor operate by complicated mechanism; nor summon any other form of gravitating force, but, by the simplest means—the mere contact of metallic surfaces of small extent, with feeble chemical agents, a power everywhere diffused through nature, but generally concealed from our senses, is mysteriously evolved, and by circulation in insulated wires, it is still more mysteriously augmented, a thousand and a thousand fold, until it breaks forth with incredible energy.
Comment upon 'The Notice of the Electro-Magnetic Machine of Mr. Thomas Davenport, of Brandon, near Rutland, Vermont, U.S.', The Annals of Electricity, Magnetism, & Chemistry; and Guardian of Experimental Science (1838), 2, 263.
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She [Rosalind Franklin] discovered in a series of beautifully executed researches the fundamental distinction between carbons that turned on heating into graphite and those that did not. Further she related this difference to the chemical constitution of the molecules from which carbon was made. She was already a recognized authority in industrial physico-chemistry when she chose to abandon this work in favour of the far more difficult and more exciting fields of biophysics.
Comment in The Times, 19 Apr 1958, shortly after Franklin's death. In Jenifer Glynn, 'Rosalind Franklin', in E. Shils and C. Blacker (eds.), Cambridge Women: Twelve Portraits (1996), 206.
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Simple molecules combine to make powerful chemicals. Simple cells combine to make powerful life-forms. Simple electronics combine to make powerful computers. Logically, all things are created by a combination of simpler, less capable components. Therefore, a supreme being must be in our future, not our origin. What if “God” is the consciousness that will be created when enough of us are connected by the Internet?!!
Thoughts by character Dogbert in Dilbert cartoon strip (11 Feb 1996).
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Since it is proposed to regard chemical reactions as electrical transactions in which reagents act by reason of a constitutional affinity either for electrons or for atomic nuclei, it is important to be able to recognize which type of reactivity any given reagent exhibits.
'Principles of an Electronic Theory of Organic Reactions', Chemical Reviews (1934), 15, 265.
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Since Pawlow [Pavlov] and his pupils have succeeded in causing the secretion of saliva in the dog by means of optic and acoustic signals, it no longer seems strange to us that what the philosopher terms an 'idea' is a process which can cause chemical changes in the body.
The Mechanistic Conception of Life (1912), 63.
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So many of the chemical reactions occurring in living systems have been shown to be catalytic processes occurring isothermally on the surface of specific proteins, referred to as enzymes, that it seems fairly safe to assume that all are of this nature and that the proteins are the necessary basis for carrying out the processes that we call life.
In 'The Physical Basis of Life', (1951), 39. As given in Andrew Brown, J.D. Bernal: The Sage of Science (2005), 359.
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So there he is at last. Man on the moon. The poor magnificent bungler! He can't even get to the office without undergoing the agonies of the damned, but give him a little metal, a few chemicals, some wire and twenty or thirty billion dollars and, vroom! there he is, up on a rock a quarter of a million miles up in the sky.
[Written when the first manned mission to the Moon, Apollo 11, landed (20 Jul 1969).]
'Why on Earth Are We There? Because It's Impossible', New York Times (21 Jul 1969), 17.
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Something is as little explained by means of a distinctive vital force as the attraction between iron and magnet is explained by means of the name magnetism. We must therefore firmly insist that in the organic natural sciences, and thus also in botany, absolutely nothing has yet been explained and the entire field is still open to investigation as long as we have not succeeded in reducing the phenomena to physical and chemical laws.
Grundzüge der Wissenschaftlichen Botanik nebst einer Methodologischen Einleitung als Anleitung zum Studium der Planze [Principles of Scientific Botany] (1842-3), Vol. 1, 49. Trans. Kenneth L. Caneva, Robert Mayer and the Conservation of Energy (1993), 108.
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Speaking one day to Monsieur de Buffon, on the present ardor of chemical inquiry, he affected to consider chemistry but as cookery, and to place the toils of the laboratory on the footing with those of the kitchen. I think it, on the contrary, among the most useful of sciences, and big with future discoveries for the utility and safety of the human race.
Letter to Rev. James Madison (Paris, 19 Jul 1788). In Thomas Jefferson and John P. Foley (ed.), The Jeffersonian Cyclopedia (1900), 135. From H.A. Washington, The Writings of Thomas Jefferson (1853-54). Vol 2, 431.
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Suppose you were given a watch, a tube to sight with and a string, and then asked to determine the distance to the nearest star. Or you were asked the chemical composition, pressure or temperature of the Sun. A hundred or more years ago, these questions seemed impossible. Now astronomers are answering them all the time, and they believe their answers. Why? Because there are many parallel ways and tests, and they all give the same answers.
As quoted in John Noble Wilford, 'Sizing up the Cosmos: An Astronomers Quest', New York Times (12 Mar 1991), C10.
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Television, films, and newspapers are forms of pollution for us and our children. They sow seeds of violence and anxiety in us and pollute our consciousness, just as we destroy our environment by farming with chemicals, clear-cutting the trees, and polluting the water. We need to protect the ecology of the Earth and the ecology of the mind, or this kind of violence and recklessness will spill over into even more areas of life.
In Love in Action: Writings on Nonviolent Social Change (1993), 132.
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The ‘Doctrine of Uniformity’ in Geology, as held by many of the most eminent of British Geologists, assumes that the earth’s surface and upper crust have been nearly as they are at present in temperature, and other physical qualities, during millions of millions of years. But the heat which we know, by observation, to be now conducted out of the earth yearly is so great, that if this action has been going on with any approach to uniformity for 20,000 million years, the amount of heat lost out of the earth would have been about as much as would heat, by 100 Cent., a quantity of ordinary surface rock of 100 times the earth’s bulk. This would be more than enough to melt a mass of surface rock equal in bulk to the whole earth. No hypothesis as to chemical action, internal fluidity, effects of pressure at great depth, or possible character of substances in the interior of the earth, possessing the smallest vestige of probability, can justify the supposition that the earth’s upper crust has remained nearly as it is, while from the whole, or from any part, of the earth, so great a quantity of heat has been lost.
In 'The “Doctrine of Uniformity” in Geology Briefly Refuted' (1866), Popular Lectures and Addresses (1891), Vol. 2, 6-7.
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The advances of biology during the past 20 years have been breathtaking, particularly in cracking the mystery of heredity. Nevertheless, the greatest and most difficult problems still lie ahead. The discoveries of the 1970‘s about the chemical roots of memory in nerve cells or the basis of learning, about the complex behavior of man and animals, the nature of growth, development, disease and aging will be at least as fundamental and spectacular as those of the recent past.
As quoted in 'H. Bentley Glass', New York Times (12 Jan 1970), 96.
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The analysis of man discloses three chemical elements - a job, a meal and a woman.
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The attempt of Lavoisier to reform chemical nomenclature is premature. One single experiment may destroy the whole filiation of his terms; and his string of sulphates, sulphites, and sulphures, may have served no end than to have retarded the progress of science by a jargon, from the confusion of which time will be requisite to extricate us.
Letter to Rev. James Madison (Paris, 1788). In Thomas Jefferson and John P. Foley (ed.), The Jeffersonian Cyclopedia (1900), 135. From H.A. Washington, The Writings of Thomas Jefferson (1853-54). Vol 2, 432.
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The beginning of civilisation is the discovery of some useful arts, by which men acquire property, comforts, or luxuries. The necessity or desire of preserving them leads to laws and social institutions. The discovery of peculiar arts gives superiority to particular nations ... to subjugate other nations, who learn their arts, and ultimately adopt their manners;— so that in reality the origin as well as the progress and improvement of civil society is founded in mechanical and chemical inventions.
Consolations In Travel; or, the Last Days of a Philosopher (1830), 228.
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The blood corpuscles take up the atmospheric oxygen in the lungs, and the vital chemical process accordingly depends essentially on the combination of oxygen absorbed by blood corpuscles with the combustible constituents of the blood to form carbonic acid and water.
Quoted in Joseph Stewart Fruton Proteins, Enzymes, Genes: The Interplay of Chemistry and Biology (1999), 240.
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The cell, this elementary keystone of living nature, is far from being a peculiar chemical giant molecule or even a living protein and as such is not likely to fall prey to the field of an advanced chemistry. The cell is itself an organism, constituted of many small units of life.
Quoted in Joseph S. Fruton, Proteins, Enzymes, Genes: The Interplay of Chemistry and Biology (1999), 59.
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The cell, too, has a geography, and its reactions occur in colloidal apparatus, of which the form, and the catalytic activity of its manifold surfaces, must efficiently contribute to the due guidance of chemical reactions.
'Some Aspects of Biochemistry', The Irish Journal of Medical Science (1932), 79, 344.
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The chemical compounds are comparable to a system of planets in that the atoms are held together by chemical affinity. They may be more or less numerous, simple or complex in composition, and in the constitution of the materials, they play the same role as Mars and Venus do in our planetary system, or the compound members such as our earth with its moon, or Jupiter with its satellites... If in such a system a particle is replaced by one of different character, the equilibrium can persist, and then the new compound will exhibit properties similar to those shown by the original substance.
Quoted in Ralph Oesper, The Human Side of Scientists (1975), 55.
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The Chemical conviction
That Nought be lost
Enable in Disaster
My fractured Trust—
The Faces of the Atoms
If I shall see
How more the Finished Creatures
Departed Me!
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The Chemical conviction
That Nought be lost
Enable in Disaster
My fractured Trust—
The Faces of the Atoms
If I shall see
How more the Finished Creatures
Departed Me!
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The chemical differences among various species and genera of animals and plants are certainly as significant for the history of their origins as the differences in form. If we could define clearly the differences in molecular constitution and functions of different kinds of organisms, there would be possible a more illuminating and deeper understanding of question of the evolutionary reactions of organisms than could ever be expected from morphological considerations.
'Uber das Vorkommen von Haemoglobin in den Muskeln der Mollusken und die Verbreitung desselben in den lebenden Organismen', Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere, 1871, 4, 318-9. Trans. Joseph S. Fruton, Proteins, Enzymes, Genes: The Interplay of Chemistry and Biology (1999), 270.
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The chemical or physical inventor is always a Prometheus. There is no great invention, from fire to flying, which has not been hailed as an insult to some god. But if every physical and chemical invention is a blasphemy, every biological invention is a perversion. There is hardly one which, on first being brought to the notice of an observer from any nation which had not previously heard of their existence, would not appear to him as indecent and unnatural.
Lecture (4 Feb 1923) to the Heretics Society, Cambridge University, published in Daedalus; or, Science and the Future (1924), 44.
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The chemists who uphold dualism are far from being agreed among themselves; nevertheless, all of them in maintaining their opinion, rely upon the phenomena of chemical reactions. For a long time the uncertainty of this method has been pointed out: it has been shown repeatedly, that the atoms put into movement during a reaction take at that time a new arrangement, and that it is impossible to deduce the old arrangement from the new one. It is as if, in the middle of a game of chess, after the disarrangement of all the pieces, one of the players should wish, from the inspection of the new place occupied by each piece, to determine that which it originally occupied.
Chemical Method (1855), 18.
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The climate of Colorado contains more of the essential elements which effectively promote health than that of any other country. These requisites are found in the chemical composition of the atmosphere; in the dry, pure, clean, soft, yet stimulating breezes which quicken circulation and multiply the corpuscles of the blood; in the tonic effect and exhilarating influence of the ozone; in the flood of its life-giving germ-destroying sunshine …
From F.H. Faus, 'Pike’s Peak Region Calls', Rock Island Magazine (Aug 1920), 15, No. 8, 4.
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The concept of an independent system is a pure creation of the imagination. For no material system is or can ever be perfectly isolated from the rest of the world. Nevertheless it completes the mathematician’s “blank form of a universe” without which his investigations are impossible. It enables him to introduce into his geometrical space, not only masses and configurations, but also physical structure and chemical composition. Just as Newton first conclusively showed that this is a world of masses, so Willard Gibbs first revealed it as a world of systems.
The Order of Nature: An Essay (1917), 126.
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The constant conditions which are maintained in the body might be termed equilibria. That word, however, has come to have fairly exact meaning as applied to relatively simple physico-chemical states, in closed systems, where known forces are balanced. The coordinated physiological processes which maintain most of the steady states in the organism are so complex and so peculiar to living beings—involving, as they may, the brain and nerves, the heart, lungs, kidneys and spleen, all working cooperatively—that I have suggested a special designation for these states, homeostasis. The word does not imply something set and immobile, a stagnation. It means a condition—a condition which may vary, but which is relatively constant.
In The Wisdom of the Body (1932), 24.
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The digestive canal is in its task a complete chemical factory. The raw material passes through a long series of institutions in which it is subjected to certain mechanical and, mainly, chemical processing, and then, through innumerable side-streets, it is brought into the depot of the body. Aside from this basic series of institutions, along which the raw material moves, there is a series of lateral chemical manufactories, which prepare certain reagents for the appropriate processing of the raw material.
Speech to the Society of Russian Physicians (Dec 1874). as translated in Daniel P. Todes, Pavlov’s Physiology Factory: Experiment, Interpretation, Laboratory Enterprise (2002), 155.
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The discovery of an interaction among the four hemes made it obvious that they must be touching, but in science what is obvious is not necessarily true. When the structure of hemoglobin was finally solved, the hemes were found to lie in isolated pockets on the surface of the subunits. Without contact between them how could one of them sense whether the others had combined with oxygen? And how could as heterogeneous a collection of chemical agents as protons, chloride ions, carbon dioxide, and diphosphoglycerate influence the oxygen equilibrium curve in a similar way? It did not seem plausible that any of them could bind directly to the hemes or that all of them could bind at any other common site, although there again it turned out we were wrong. To add to the mystery, none of these agents affected the oxygen equilibrium of myoglobin or of isolated subunits of hemoglobin. We now know that all the cooperative effects disappear if the hemoglobin molecule is merely split in half, but this vital clue was missed. Like Agatha Christie, Nature kept it to the last to make the story more exciting. There are two ways out of an impasse in science: to experiment or to think. By temperament, perhaps, I experimented, whereas Jacques Monod thought.
From essay 'The Second Secret of Life', collected in I Wish I'd Made You Angry Earlier (1998), 263-5.
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The effort to eliminate synthetic pesticides because of unsubstantiated fears about residues in food will make fruits and vegetables more expensive, decrease consumption, and thus increase cancer rates. The levels of synthetic pesticide residues are trivial in comparison to natural chemicals, and thus their potential for cancer causation is extremely low. [Ames believes that “to eat your veggies” is the best way to prevent cancer.]
Paper to the American Chemical Society, 'Pollution, Pesticides and Cancer Misconceptions.' As cited by Art Drysdale, 'Latest Insider News: Natural vs. Synthetic Chemical Pesticides' (14 Feb 1999), on the mitosyfraudes.org website. Bruce Ames has written a similar sentiment in various other publications.
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The elements of the living body have the chemical peculiarity of forming with each other most numerous combinations and very large molecules, consisting of five, six or even seven different elements.
In discourse (10 Dec 1893) to General Meeting, Nassau Association for Natural Science, Wiesbaden, Germany. Printed in 'The Distribution of the Organic Elements', The Chemical News and Journal of Industrial Science (1895), 71, No. 1832, 19.
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The essential molecule of reproduction, DNA, … is composed of only four nitrogen bases (adenine, thymine, guanine, and cytosine), the sugar deoxyribose, and a phosphate. DNA’s intermediary, RNA, differs only by the substitution of the sugar ribose for deoxyribose and the nitrogen base uracil for thymine. The proteins of living organisms are made with a mere 20 amino acids, all arranged in a “left-handed” configuration. Taking into account all 28 building blocks, or “letters” (20 amino acids, five bases, two sugars, and one phosphate), the message is clear: With such a limited alphabet, all life must have had a common chemical origin.
In 'Cosmochemistry The Earliest Evolution', The Science Teacher (Oct 1983), 50, No. 7, 35.
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The establishment of the periodic law may truly be said to mark a line in chemical science, and we anticipate that its application and and extension will be fraught With the most important consequences. It reminds us how important above all things is the correct determination of the fundamental constants of our science—the atomic weights of the elements, about which in many cases great uncertainty prevails; it is much to be desired that this may not long remain the case. It also affords the strongest encouragement to the chemist to persevere in the search for new elements.
In The Encyclopaedia Britannica: Ninth Edition (1877), Vol. 5, 714.
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The existence of life must be considered as an elementary fact that can not be explained, but must be taken as a starting point in biology, in a similar way as the quantum of action, which appears as an irrational element from the point of view of classical mechanical physics, taken together with the existence of elementary particles, forms the foundation of atomic physics. The asserted impossibility of a physical or chemical explanation of the function peculiar to life would in this sense be analogous to the insufficiency of the mechanical analysis for the understanding of the stability of atoms.
'Light and Life', Nature, 1933, 131, 458.
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The exterior form and the chemical composition are each other's image.
Traité de mineralogie ... Publié par le conseil des mines (1801), Vol. 1, xxxi, trans. Albert V. and Marguerite Carozzi.
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The fact is the physical chemists never use their eyes and are most lamentably lacking in chemical culture. It is essential to cast out from our midst, root and branch, this physical element and return to our laboratories.
'Ionomania in Extremis', Chemistry and Industry (1936), 14, 917.
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The fact is, a biologist to-day [1928] is pretty much where an engineer would be if he knew even in detail the cycle of chemical changes which took place within an internal combustion engine but was wholly ignorant of the disposition of tho moving parts.
As guest of honour, closing day address (Jun 1928), Sixth Colloid Symposium, Toronto, Canada, 'Living Matter', printed in Harry Boyer Weiser (ed.), Colloid Symposium Monograph (1928), Vol. 6, 7.
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The fact that this chain of life existed [at volcanic vents on the seafloor] in the black cold of the deep sea and was utterly independent of sunlight—previously thought to be the font of all Earth’s life—has startling ramifications. If life could flourish there, nurtured by a complex chemical process based on geothermal heat, then life could exist under similar conditions on planets far removed from the nurturing light of our parent star, the Sun.
Quoted in Peter Douglas Ward and Donald Brownlee, Rare Earth: Why Complex Life is Uncommon in the Universe (2000), 1, without citation.
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The first entirely vital action, so termed because it is not effected outside the influence of life, consists in the creation of the glycogenic material in the living hepatic tissue. The second entirely chemical action, which can be effected outside the influence of life, consists in the transformation of the glycogenic material into sugar by means of a ferment.
Sur le Méchanisme de la Fonction du Sucre dans Ie Foie (1857), 583. Translated in Joseph S. Fruton, Proteins, Enzymes, Genes: The Interplay of Chemistry and Biology (1999), 340.
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The fundamental biological variant is DNA. That is why Mendel's definition of the gene as the unvarying bearer of hereditary traits, its chemical identification by Avery (confirmed by Hershey), and the elucidation by Watson and Crick of the structural basis of its replicative invariance, are without any doubt the most important discoveries ever made in biology. To this must be added the theory of natural selection, whose certainty and full significance were established only by those later theories.
In Jacques Monod and Austryn Wainhouse (trans.), Chance and Necessity: An Essay on the Natural Philosophy of Modern Biology (1971), 104.
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The Gaia Hypothesis asserts that Earth’s atmosphere is continually interacting with geology (the lithosphere). Earth’s cycling waters (the hydrosphere), and everything that lives (the biosphere). … The image is that the atmosphere is a circulatory system for life’s bio-chemical interplay. If the atmosphere is pan of a larger whole that has some of the qualities of an organism, one of those qualities we must now pray for is resilience.
In Praise of Nature
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The general disposition of the land [in the Periodic Kingdom] is one of metals in the west, giving way, as you travel eastward, to a varied landscape of nonmetals, which terminates in largely inert elements at the eastern shoreline. To the south of the mainland, there is an offshore island, which we shall call the Southern Island. It consists entirely of metals of subtly modulated personality. North of the mainland, situated rather like Iceland off the northwestern edge of Europe, lies a single, isolated region-hydrogen. This simple but gifted element is an essential outpost of the kingdom, for despite its simplicity it is rich in chemical personality. It is also the most abundant element in the universe and the fuel of the stars.
In The Periodic Kingdom: A Journey Into the Land of the Chemical Elements (1995), 9.
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The general knowledge of our author [Leonhard Euler] was more extensive than could well be expected, in one who had pursued, with such unremitting ardor, mathematics and astronomy as his favorite studies. He had made a very considerable progress in medical, botanical, and chemical science. What was still more extraordinary, he was an excellent scholar, and possessed in a high degree what is generally called erudition. He had attentively read the most eminent writers of ancient Rome; the civil and literary history of all ages and all nations was familiar to him; and foreigners, who were only acquainted with his works, were astonished to find in the conversation of a man, whose long life seemed solely occupied in mathematical and physical researches and discoveries, such an extensive acquaintance with the most interesting branches of literature. In this respect, no doubt, he was much indebted to an uncommon memory, which seemed to retain every idea that was conveyed to it, either from reading or from meditation.
In Philosophical and Mathematical Dictionary (1815), 493-494.
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The genotypic constitution of a gamete or a zygote may be parallelized with a complicated chemico-physical structure. This reacts exclusively in consequence of its realized state, but not in consequence of the history of its creation. So it may be with the genotypical constitution of gametes and zygotes: its history is without influence upon its reactions, which are determined exclusively by its actual nature. The genotype-conception is thus an 'ahistoric' view of the reactions of living beings—of course only as far as true heredity is concerned. This view is an analog to the chemical view, as already pointed out; chemical compounds have no compromising ante-act, H2O is always H2O, and reacts always in the same manner, whatsoever may be the 'history' of its formation or the earlier states of its elements. I suggest that it is useful to emphasize this 'radical' ahistoric genotype-conception of heredity in its strict antagonism to the transmission—or phenotype-view.
'The Genotype Conception of Heredity', The American Naturalist (1911), 45, 129.
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The glimpses of chemical industry's services to man afforded by this book could be presented only by utilizing innumerable chemical products. The first outline of its plan began to take shape on chemically produced notepaper with the aid of a chemically-treated graphite held in a synthetic resin pencil. Early corrections were made with erasers of chemically compounded rubber. In its ultimate haven on the shelves of your bookcase, it will rest on a coating of chemical varnish behind a pane of chemically produced glass. Nowhere has it been separated from that industry's products.
Man in a Chemical World (1937), L'Envoi, 284.
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The idea of an atom has been so constantly associated with incredible assumptions of infinite strength, absolute rigidity, mystical actions at a distance, and individuality, that chemists and many other reasonable naturalists of modern times, losing all patience with it, have dismissed it to the realms of metaphysics, and made it smaller than ‘anything we can conceive.’ But if atoms are inconceivably small, why are not all chemical actions infinitely swift? Chemistry is powerless to deal with this question, and many others of paramount importance, if barred by the hardness of its fundamental assumptions, from contemplating the atom as a real portion of matter occupying a finite space, and forming not an immeasurably small constituent of any palpable body.
Sir William Thomson and Peter Guthrie Tait, A Treatise on Natural Philosophy (1883), Vol. I, Part 2, 495.
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The inducing substance, on the basis of its chemical and physical properties, appears to be a highly polymerized and viscous form of sodium desoxyribonucleate. On the other hand, the Type m capsular substance, the synthesis of which is evoked by this transforming agent, consists chiefly of a non-nitrogenous polysaccharide constituted of glucose-glucuronic acid units linked in glycosidic union. The presence of the newly formed capsule containing this type-specific polysaccharide confers on the transformed cells all the distinguishing characteristics of Pneumococcus Type III. Thus, it is evident that the inducing substance and the substance produced in turn are chemically distinct and biologically specific in their action and that both are requisite in determining the type of specificity of the cell of which they form a part. The experimental data presented in this paper strongly suggest that nucleic acids, at least those of the desoxyribose type, possess different specificities as evidenced by the selective action of the transforming principle.
Oswald T. Avery (1877-1955), Colin Macleod (1909-72) and Maclyn McCarty (1911-2005), ‘Studies in the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types', Journal of Experimental Medicine 1944, 79, 152.
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The influence of electricity in producing decompositions, although of inestimable value as an instrument of discovery in chemical inquiries, can hardly be said to have been applied to the practical purposes of life, until the same powerful genius [Davy] which detected the principle, applied it, by a singular felicity of reasoning, to arrest the corrosion of the copper-sheathing of vessels. … this was regarded as by Laplace as the greatest of Sir Humphry's discoveries.
Reflections on the Decline of Science in England (1830), 16.
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The inventor and the research man are confused because they both examine results of physical or chemical operations. But they are exact opposites, mirror images of one another. The research man does something and does not care [exactly] what it is that happens, he measures whatever it is. The inventor wants something to happen, but does not care how it happens or what it is that happens if it is not what he wants.
Aphorism listed Frederick Seitz, The Cosmic Inventor: Reginald Aubrey Fessenden (1866-1932) (1999), 54, being Transactions of the American Philosophical Society, Held at Philadelphia For Promoting Useful Knowledge, Vol. 86, Pt. 6.
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The major credit I think Jim and I deserve … is for selecting the right problem and sticking to it. It’s true that by blundering about we stumbled on gold, but the fact remains that we were looking for gold. Both of us had decided, quite independently of each other, that the central problem in molecular biology was the chemical structure of the gene. … We could not see what the answer was, but we considered it so important that we were determined to think about it long and hard, from any relevant point of view.
In What Mad Pursuit (1990), 74-75.
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The mathematics of cooperation of men and tools is interesting. Separated men trying their individual experiments contribute in proportion to their numbers and their work may be called mathematically additive. The effect of a single piece of apparatus given to one man is also additive only, but when a group of men are cooperating, as distinct from merely operating, their work raises with some higher power of the number than the first power. It approaches the square for two men and the cube for three. Two men cooperating with two different pieces of apparatus, say a special furnace and a pyrometer or a hydraulic press and new chemical substances, are more powerful than their arithmetical sum. These facts doubtless assist as assets of a research laboratory.
Quoted from a speech delivered at the fiftieth anniversary of granting of M.I.T's charter, in Guy Suits, 'Willis Rodney Whitney', National Academy of Sciences, Biographical Memoirs (1960), 352.
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The mechanist is intimately convinced that a precise knowledge of the chemical constitution, structure, and properties of the various organelles of a cell will solve biological problems. This will come in a few centuries. For the time being, the biologist has to face such concepts as orienting forces or morphogenetic fields. Owing to the scarcity of chemical data and to the complexity of life, and despite the progresses of biochemistry, the biologist is still threatened with vertigo.
Problems of Morphogenesis in Ciliates: The Kinetosomes in Development, Reproduction and Evolution (1950), 92-3.
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The morphological characteristics of plant and animal species form the chief subject of the descriptive natural sciences and are the criteria for their classification. But not until recently has it been recognized that in living organisms, as in the realm of crystals, chemical differences parallel the variation in structure.
The Specificity of Serological Reactions (1936), 3.
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The native intellectual powers of men in different times, are not so much the causes of the different success of their labours, as the peculiar nature of the means and artificial resources in their possession‎. Independent of vessels of glass, there could have been no accurate manipulations in common chemistry: the air pump was necessary for live investigation of the properties of gaseous matter; and without the Voltaic apparatus, there was no possibility of examining the relations of electrical polarities to chemical attractions.
In Elements of Chemical Philosophy (1812), Vol. 1, Part 1, 28-29.
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The nature of the atoms, and the forces called into play in their chemical union; the interactions between these atoms and the non-differentiated ether as manifested in the phenomena of light and electricity; the structures of the molecules and molecular systems of which the atoms are the units; the explanation of cohesion, elasticity, and gravitation—all these will be marshaled into a single compact and consistent body of scientific knowledge.
In Light Waves and Their Uses? (1902), 163.
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The night before Easter Sunday of that year (1920) I awoke, turned on the light, and jotted down a few notes on a tiny slip of thin paper. Then I fell asleep again. It occurred to me at six o’clock in the morning that during the night I had written down something most important, but I was unable to decipher the scrawl. The next night, at three o’clock, the idea returned. It was the design of an experiment to determine whether the hypothesis of chemical transmission that I had uttered seventeen years ago was correct. I got up immediately, went to the laboratory, and performed a simple experiment on a frog heart according to the nocturnal design. I have to describe this experiment briefly since its results became the foundation of the theory of chemical transmission of the nervous impulse. The hearts of two frogs were isolated, the first with its nerves, the second without. Both hearts were attached to Straub cannulas filled with a little Ringer solution. The vagus nerve of the first heart was stimulated for a few minutes. Then the Ringer solution that had been in the first heart during the stimulation of the vagus was transferred to the second heart. It slowed and its beats diminished just as if its vagus had been stimulated. Similarly, when the accelerator nerve was stimulated and the Ringer from this period transferred, the second heart speeded up and its beats increased. These results unequivocally proved that the nerves do not influence the heart directly but liberate from their terminals specific chemical substances which, in their turn, cause the well-known modifications of the function of the heart characteristic of the stimulation of its nerves.
'An Autobiographic Sketch', Perspectives in Biology and Medicine (1960), 4, 17.
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The physiological combustion theory takes as its starting point the fundamental principle that the amount of heat that arises from the combustion of a given substance is an invariable quantity–i.e., one independent of the circumstances accompanying the combustion–from which it is more specifically concluded that the chemical effect of the combustible materials undergoes no quantitative change even as a result of the vital process, or that the living organism, with all its mysteries and marvels, is not capable of generating heat out of nothing.
Bemerkungen über das mechanische Aequivalent der Wärme [Remarks on the Mechanical Equivalent of Heat] (1851), 17-9. Trans. Kenneth L. Caneva, Robert Mayer and the Conservation of Energy (1993), 240.
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The precise equivalence of the chromosomes contributed by the two sexes is a physical correlative of the fact that the two sexes play, on the whole, equal parts in hereditary transmission, and it seems to show that the chromosomal substance, the chromatin, is to be regarded as the physical basis of inheritance. Now, chromatin is known to be closely similar to, if not identical with, a substance known as nuclein (C29H49N9O22, according to Miescher), which analysis shows to be a tolerably definite chemical compased of nucleic acid (a complex organic acid rich in phosphorus) and albumin. And thus we reach the remarkable conclusion that inheritance may, perhaps, be effected by the physical transmission of a particular chemical compound from parent to offspring.
In An Atlas of the Fertilization and Karyokinesis of the Ovum (1895), 4.
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The question whether atoms exist or not... belongs rather to metaphysics. In chemistry we have only to decide whether the assumption of atoms is an hypothesis adapted to the explanation of chemical phenomena... whether a further development of the atomic hypothesis promises to advance our knowledge of the mechanism of chemical phenomena... I rather expect that we shall some day find, for what we now call atoms, a mathematico-mechanical explanation, which will render an account of atomic weight, of atomicity, and of numerous other properties of the so-called atoms.
Laboratory (1867), 1, 303.
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The recent ruling by the Supreme Court restricting obscenity in books, magazines and movies, requires that we re-examine our own journals for lewd contents. The recent chemical literature provides many examples of words and concepts whose double meaning and thinly veiled overtones are an affront to all clean chemists. What must a layman think of ‘coupling constants’, ‘tickling techniques’, or indeed ‘increased overlap’? The bounds of propriety are surely exceeded when heterocyclic chemists discuss homoenolization.
In Chemical Engineering News (8 Oct 1973), 68.
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The science of genetics is in a transition period, becoming an exact science just as the chemistry in the times of Lavoisier, who made the balance an indispensable implement in chemical research.
The Genotype Conception of Heredity', The American Naturalist (1911), 45, 131.
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The significant chemicals of living tissue are rickety and unstable, which is exactly what is needed for life.
As shown, without citation, in Randy Moore, Writing to Learn Science (1997), 226.
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The solar system was formed 4.6 billion years ago, and the oldest fossils on Earth have been dated at about 3.8 billion years. Sometime between these two points, the chemicals of the young planet were organized into the responsive, reproducing systems we call “life.”
In 'Cosmochemistry The Earliest Evolution', The Science Teacher (Oct 1983), 50, No. 7, 35.
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The specific character of the greater part of the toxins which are known to us (I need only instance such toxins as those of tetanus and diphtheria) would suggest that the substances produced for effecting the correlation of organs within the body, through the intermediation of the blood stream, might also belong to this class, since here also specificity of action must be a distinguishing characteristic. These chemical messengers, however, or 'hormones' (from όρμάω, I excite or arouse), as we might call them, have to be carried from the organ where they are produced to the organ which they affect by means of the blood stream and the continually recurring physiological needs of the organism must determine their repeated production and circulation through the body.
'The Chemical Correlation of the Functions of the Body', The Lancet (1905), ii, 340.
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The steady states of the fluid matrix of the body are commonly preserved by physiological reactions, i.e., by more complicated processes than are involved in simple physico-chemical equilibria. Special designations, therefore, are appropriate:—“homeostasis” to designate stability of the organism; “homeostatic conditions,” to indicate details of the stability; and “homeostatic reactions,” to signify means for maintaining stability.
'Physiological Regulation of Normal States: Some Tentative Postulates Concerning Biological Homeostatics', 1926. Reprinted in L. L. Langley (ed.), Homeostasis: Origins of the Concept (1973), 246.
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The structure known, but not yet accessible by synthesis, is to the chemist what the unclimbed mountain, the uncharted sea, the untilled field, the unreached planet, are to other men … The unique challenge which chemical synthesis provides for the creative imagination and the skilled hand ensures that it will endure as long as men write books, paint pictures, and fashion things which are beautiful, or practical, or both.
In 'Art and Science in the Synthesis of Organic Compounds: Retrospect and Prospect', in Maeve O'Connor (ed.), Pointers and Pathways in Research (1963), 41.
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The struggle between the unitary and dualistic theories of chemical affinity, which raged for nearly a century, was a form of civil war between inorganic and organic chemists.
Comment made on a postcard sent to Robin O. Gandy. Reproduced in Andrew Hodges, Alan Turing: The Enigma (1983), 513.
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The sum of human happiness would not necessarily be reduced if for ten years every physical and chemical laboratory were closed and the patient and resourceful energy displayed in them transferred to the lost art of getting on together and finding the formula for making both ends meet in the scale of human life.
In a speech to the British Association for the Advancement of Science, Leeds, September 4, 1927.
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The sun's rays are the ultimate source of almost every motion which takes place on the surface of the earth. By their heat are produced all winds, and those disturbances in the electric equilibrium of the atmosphere which give rise to the phenomena of terrestrial magnetism. By their vivifying action vegetables are elaborated from inorganic matter, and become in their turn the support of animals and of man, and the sources of those great deposits of dynamical efficiency which are laid up for human use in our coal strata. By them the waters of the sea are made to circulate in vapor through the air, and irrigate the land, producing springs and rivers. By them are produced all disturbances of the chemical equilibrium of the elements of nature which, by a series of compositions and decompositions, give rise to new products, and originate a transfer of materials. Even the slow degradation of the solid constituents of the surface, in which its chief geological changes consist, and their diffusion among the waters of the ocean, are entirely due to the abrasion of the wind, rain, and tides, which latter, however, are only in part the effect of solar influence and the alternate action of the seasons.
from Outlines of Astronomy (1849), 237.
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The Superfund legislation set up a system of insurance premiums collected from the chemical industry to clean up toxic wastes. This new program may prove to be as far-reaching and important as any accomplishment of my administration. The reduction of the threat to America's health and safety from thousands of toxic-waste sites will continue to be an urgent but bitterly fought issue—another example for the conflict between the public welfare and the profits of a few private despoilers of our nation's environment.
Keeping Faith: Memoirs of a President (1980), 591.
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The title affixed to it is “The Chemical Theory of Electrolytes,” but it is a bigger thing than this: it really is an attempt at an electrolytic theory of chemistry.
On Svante Arrhenius’ Theorie Chemique des Electrolytes, abstract and report by Oliver Lodge.
56th Report of The British Association for the Advancement of Science, 1886, 362.
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The varieties of chemical substances actually found in living things are vastly more restricted than the possible varieties. A striking illustration is that if one molecule each of all the possible types of proteins were made, they would together weigh more than the observable universe. Obviously there are a fantastically large number of protein types that are not made by living cells.
In The Closing Circle: Nature, Man, and Technology (2014).
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Their specific effect on the glucosides might thus be explained by assuming that the intimate contact between the molecules necessary for the release of the chemical reaction is possible only with similar geometrical configurations. To give an illustration I will say that enzyme and glucoside must fit together like lock and key in order to be able to exercise a chemical action on each other. This concept has undoubtedly gained in probability and value for stereochemical research, after the phenomenon itself was transferred from the biological to the purely chemical field. It is an extension of the theory of asymmetry without being a direct consequence of it: for the conviction that the geometrical structure of the molecule even for optical isomers exercises such a great influence on the chemical affinities, in my opinion could only be gained by new actual observations.
'Einfluss der Configuration auf die wirkung der Enzyme', Berichte der deutschen Chemischen Gesellschaft, 1894, 27, 2985-93. Trans. B. Holmstedt and G. Liljestrand (eds.) Readings in Pharmacology (1963), 251.
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There are fewer chemical pollutants in the air. Our drinking water is safer. Our food standards have been raised. We’ve cleaned up more toxic waste sites in three years than the previous administrations did in twelve. The environment is cleaner, and we have fought off the most vigorous assault on environmental protection since we began to protect the environment in 1970. We are moving in the right direction to the 21st century.
Remarks at the University of Pennsylvania in Philadelphia, Pennsylvania (29 Oct 1996) while seeking re-election. On the American Presidency Project web page.
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There are various causes for the generation of force: a tensed spring, an air current, a falling mass of water, fire burning under a boiler, a metal that dissolves in an acid—one and the same effect can be produced by means of all these various causes. But in the animal body we recognise only one cause as the ultimate cause of all generation of force, and that is the reciprocal interaction exerted on one another by the constituents of the food and the oxygen of the air. The only known and ultimate cause of the vital activity in the animal as well as in the plant is a chemical process.
'Der Lebensprocess im Thiere und die Atmosphare', Annalen der Chemie und Pharmacie (1841), 41, 215-7. Trans. Kenneth L. Caneva, Robert Mo.yer and the Conservation of Energy (1993), 78.
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There are, I believe, very few maxims in philosophy that have laid firmer hold upon the mind, than that air, meaning atmospherical air (free from various foreign matters, which were always supposed to be dissolved, and intermixed with it) is a simple elementary substance, indestructible, and unalterable, at least as much so as water is supposed to be. In the course of my enquiries, I was, however, soon satisfied that atmospherical air is not an unalterable thing; for that the phlogiston with which it becomes loaded from bodies burning in it, and animals breathing it, and various other chemical processes, so far alters and depraves it, as to render it altogether unfit for inflammation, respiration, and other purposes to which it is subservient; and I had discovered that agitation in water, the process of vegetation, and probably other natural processes, by taking out the superfluous phlogiston, restore it to its original purity.
'On Dephlogisticated Air, and the Constitution of the Atmosphere', in The Discovery of Oxygen, Part I, Experiments by Joseph Priestley 1775 (Alembic Club Reprint, 1894), 6.
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There is an occasional glimmer of fertility [as compounds], the chemical equivalent of a blade of grass [in a desert]. So, gone … is the justification for “inert.” [Group 0 elements] are now known collectively as the noble gases, a name intended to imply a kind of chemical aloofness rather than a rigorous chastity.
In The Periodic Kingdom: A Journey Into the Land of the Chemical Elements (1995), 9.
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There is deposited in them [plants] an enormous quantity of potential energy [Spannkräfte], whose equivalent is provided to us as heat in the burning of plant substances. So far as we know at present, the only living energy [lebendige Kraft] absorbed during plant growth are the chemical rays of sunlight… Animals take up oxygen and complex oxidizable compounds made by plants, release largely as combustion products carbonic acid and water, partly as simpler reduced compounds, thus using a certain amount of chemical potential energy to produce heat and mechanical forces. Since the latter represent a relatively small amount of work in relation to the quantity of heat, the question of the conservation of energy reduces itself roughly to whether the combustion and transformation of the nutritional components yields the same amount of heat released by animals.
Wissenschaftliche Abhandlungen (1847), 66. Trans. Joseph S. Fruton, Proteins, Enzymes, Genes: The Interplay of Chemistry and Biology (1999), 247.
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There is no sharp boundary line separating the reactions of the immune bodies from chemical processes between crystalloids, just as in nature there exists every stage between crystalloid and colloid. The nearer the colloid particle approximates to the normal electrolyte, the nearer its compounds must obviously come to conforming to the law of simple stoichiometric proportions, and the compounds themselves to simple chemical compounds. At this point, it should be recalled that Arrhenius has shown that the quantitative relationship between toxin and antitoxin is very similar to that between acid and base.
Landsteiner and Nicholas von Jagic, 'Uber Reaktionen anorganischer Kolloide und Immunkorper', Münchener medizinischer Wochenschrift (1904), 51, 1185-1189. Trans. Pauline M. H. Mazumdar.
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There is no short cut from chemical laboratory to clinic, except one that passes too close to the morgue.
Anonymous
American Medical Association (1929) as quoted in Arabella Melville and Colin Johnson , Cured to Death: The Effects of Prescription Drugs (1982).
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There is not, we believe, a single example of a medicine having been received permanently into the Materia Medica upon the sole ground of its physical, chemical, or physiological properties. Nearly every one has become a popular remedy before being adopted or even tried by physicians; by far the greater number were first employed in countries which were and are now in a state of scientific ignorance....
Therapeutics and Materia Medica (2006), 31
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There must be some bond of union between mass and the chemical elements; and as the mass of a substance is ultimately expressed (although not absolutely, but only relatively) in the atom, a functional dependence should exist and be discoverable between the individual properties of the elements and their atomic weights. But nothing, from mushrooms to a scientific dependence can be discovered without looking and trying. So I began to look about and write down the elements with their atomic weights and typical properties, analogous elements and like atomic weights on separate cards, and soon this convinced me that the properties of the elements are in periodic dependence upon their atomic weights; and although I had my doubts about some obscure points, yet I have never doubted the universality of this law, because it could not possibly be the result of chance.
Principles of Chemistry (1905), Vol. 2, 18.
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There was once an Editor of the Chemical Society, given to dogmatic expressions of opinion, who once duly said firmly that 'isomer' was wrong usage and 'isomeride' was correct, because the ending 'er' always meant a 'do-er'. 'As in water?' snapped Sidgwick.
Obituary of Nevil Vincent Sidgwick by L. E Sutton, Proceedings of the Chemical Society (1958), 318.
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There’s a new science out called orthomolecular medicine. You correct the chemical imbalance with amino acids and vitamins and minerals that are naturally in the body.
…...
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These white crystals is what’s left of the human body when you take the water away, which makes up 96% of our bodies. Without water, we’re all just three or four pounds of chemicals.
In TV episode, spoken by character Dr. McCoy, 'The Omega Glory', Star Trek (1968).
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This frustration of reading the tabloid press… it would easy to become convinced that the human race is on a mission to divide things into two clean columns… Good or evil, healthy or deadly or natural or chemical… everything organic and natural is good, ignoring the fact that organic natural substances include arsenic… Everything chemical is bad, ignoring that fact the everything is chemicals. Everything is chemicals! The day they discover yoga mats are carcinogenic will be the happiest day of my life.
Introducing his song, 'The Fence', on DVD, Live at the Royal Albert Hall (2011).
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This is the kingdom of the chemical elements, the substances from which everything tangible is made. It is not an extensive country, for it consists of only a hundred or so regions (as we shall often term the elements), yet it accounts for everything material in our actual world. From the hundred elements that are at the center of our story, all planets, rocks, vegetation, and animals are made. These elements are the basis of the air, the oceans, and the Earth itself. We stand on the elements, we eat the elements, we are the elements. Because our brains are made up of elements, even our opinions are, in a sense, properties of the elements and hence inhabitants of the kingdom.
In 'The Terrain', The Periodic Kingdom: A Journey Into the Land of the Chemical Elements (1995), 3.
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This leads us to ask for the reasons which call for this new theory of transmutation. The beginning of things must needs lie in obscurity, beyond the bounds of proof, though within those of conjecture or of analogical inference. Why not hold fast to the customary view, that all species were directly, instead of indirectly, created after their respective kinds, as we now behold them,--and that in a manner which, passing our comprehension, we intuitively refer to the supernatural? Why this continual striving after “the unattained and dim,”—these anxious endeavors, especially of late years, by naturalists and philosophers of various schools and different tendencies, to penetrate what one of them calls “the mystery of mysteries,” the origin of species? To this, in general, sufficient answer may be found in the activity of the human intellect, “the delirious yet divine desire to know,” stimulated as it has been by its own success in unveiling the laws and processes of inorganic Nature,—in the fact that the principal triumphs of our age in physical science have consisted in tracing connections where none were known before, in reducing heterogeneous phenomena to a common cause or origin, in a manner quite analogous to that of the reduction of supposed independently originated species to a common ultimate origin,—thus, and in various other ways, largely and legitimately extending the domain of secondary causes. Surely the scientific mind of an age which contemplates the solar system as evolved from a common, revolving, fluid mass,— which, through experimental research, has come to regard light, heat, electricity, magnetism, chemical affinity, and mechanical power as varieties or derivative and convertible forms of one force, instead of independent species,—which has brought the so-called elementary kinds of matter, such as the metals, into kindred groups, and raised the question, whether the members of each group may not be mere varieties of one species,—and which speculates steadily in the direction of the ultimate unity of matter, of a sort of prototype or simple element which may be to the ordinary species of matter what the protozoa or component cells of an organism are to the higher sorts of animals and plants,—the mind of such an age cannot be expected to let the old belief about species pass unquestioned.
Asa Gray
'Darwin on the Origin of Species', The Atlantic Monthly (Jul 1860), 112-3. Also in 'Natural Selection Not Inconsistent With Natural Theology', Darwiniana: Essays and Reviews Pertaining to Darwinism (1876), 94-95.
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This new force, which was unknown until now, is common to organic and inorganic nature. I do not believe that this is a force entirely independent of the electrochemical affinities of matter; I believe, on the contrary, that it is only a new manifestation, but since we cannot see their connection and mutual dependence, it will be easier to designate it by a separate name. I will call this force catalytic force. Similarly, I will call the decomposition of bodies by this force catalysis, as one designates the decomposition of bodies by chemical affinity analysis.
In'Some Ideas on a New Force which Acts in Organic Compounds', Annales chimie physiques, 1836, 61, 146. Translated in Henry M. Leicester and Herbert S. Klickstein, A Source Book in Chemistry 1400-1900 (1952), 267.
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Those of us who were familiar with the state of inorganic chemistry in universities twenty to thirty years ago will recall that at that time it was widely regarded as a dull and uninteresting part of the undergraduate course. Usually, it was taught almost entirely in the early years of the course and then chiefly as a collection of largely unconnected facts. On the whole, students concluded that, apart from some relationships dependent upon the Periodic table, there was no system in inorganic chemistry comparable with that to be found in organic chemistry, and none of the rigour and logic which characterised physical chemistry. It was widely believed that the opportunities for research in inorganic chemistry were few, and that in any case the problems were dull and uninspiring; as a result, relatively few people specialized in the subject... So long as inorganic chemistry is regarded as, in years gone by, as consisting simply of the preparations and analysis of elements and compounds, its lack of appeal is only to be expected. The stage is now past and for the purpose of our discussion we shall define inorganic chemistry today as the integrated study of the formation, composition, structure and reactions of the chemical elements and compounds, excepting most of those of carbon.
Inaugural Lecture delivered at University College, London (1 Mar 1956). In The Renaissance of Inorganic Chemistry (1956), 4-5.
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To say that a man is made up of certain chemical elements is a satisfactory description only for those who intend to use him as a fertilizer.
…...
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Unless the chemist learns the language of mathematics, he will become a provincial and the higher branches of chemical work, that require reason as well as skill, will gradually pass out of his hands.
Quoted in Journal of the Chemical Society, 1929, 6, 254.
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We are now witnessing, after the slow fermentation of fifty years, a concentration of technical power aimed at the essential determinants of heredity, development and disease. This concentration is made possible by the common function of nucleic acids as the molecular midwife of all reproductive particles. Indeed it is the nucleic acids which, in spite of their chemical obscurity, are giving to biology a unity which has so far been lacking, a chemical unity.
Nucleic Acid (1947), 266-7.
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We divide the world…
Into chemical and natural,
Into fictional and factual.
Into science and supernatural
. But it’s actually naturally not that white and black.
From song, 'The Fence' (2010).
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We do not know of any enzymes or other chemical defined organic substances having specifically acting auto-catalytic properties such as to enable them to construct replicas of themselves. Neither was there a general principle known that would result in pattern-copying; if there were, the basis of life would be easier to come by. Moreover, there was no evidence to show that the enzymes were not products of hereditary determiners or genes, rather than these genes themselves, and they might even be products removed by several or many steps from the genes, just as many other known substances in the cell must be. However, the determiners or genes themselves must conduct, or at least guide, their own replication, so as to lead to the formation of genes just like themselves, in such wise that even their own mutations become .incorporated in the replicas. And this would probably take place by some kind of copying of pattern similar to that postulated by Troland for the enzymes, but requiring some distinctive chemical structure to make it possible. By virtue of this ability of theirs to replicate, these genes–or, if you prefer, genetic material–contained in the nuclear chromosomes and in whatever other portion of the cell manifests this property, such as the chloroplastids of plants, must form the basis of all the complexities of living matter that have arisen subsequent to their own appearance on the scene, in the whole course of biological evolution. That is, this genetic material must underlie all evolution based on mutation and selective multiplication.
'Genetic Nucleic Acid', Perspectives in Biology and Medicine (1961), 5, 6-7.
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We have very strong physical and chemical evidence for a large impact; this is the most firmly established part of the whole story. There is an unquestionable mass extinction at this time, and in the fossil groups for which we have the best record, the extinction coincides with the impact to a precision of a centimeter or better in the stratigraphic record. This exact coincidence in timing strongly argues for a causal relationship.
Referring to the theory that he, and his father (physicist Luis W. Alvarez), held that dinosaurs abruptly went extinct as a result of a 6-mile-wide asteroid or comet struck the earth. In American Geophysical Union, EOS (2 Sep 1986), as quoted and cited in John Noble Wilford, 'New Data Extend Era of Dinosaurs' New York Times (9 Nov 1986), A41.
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We may lay it down as an incontestible axiom, that, in all the operations of art and nature, nothing is created; an equal quantity of matter exists both before and after the experiment; the quality and quantity of the elements remain precisely the same; and nothing takes place beyond changes and modifications in the combination of these elements. Upon this principle the whole art of performing chemical experiments depends: We must always suppose an exact equality between the elements of the body examined and those of the products of its analysis.
Elements of Chemistry trans. Robert. Kerr, (1790, 5th Ed. 1802), Vol. 1, 226.
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We may regard the cell quite apart from its familiar morphological aspects, and contemplate its constitution from the purely chemical standpoint. We are obliged to adopt the view, that the protoplasm is equipped with certain atomic groups, whose function especially consists in fixing to themselves food-stuffs, of importance to the cell-life. Adopting the nomenclature of organic chemistry, these groups may be designated side-chains. We may assume that the protoplasm consists of a special executive centre (Leistungs-centrum) in connection with which are nutritive side-chains… The relationship of the corresponding groups, i.e., those of the food-stuff, and those of the cell, must be specific. They must be adapted to one another, as, e.g., male and female screw (Pasteur), or as lock and key (E. Fischer).
Croonian Lecture, 'On Immunity with Special Reference to Cell Life', Proceedings of the Royal Society of London, 1900, 66, 433-434.
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We must stop fretting over the minute statistical risks of cancer from chemicals or radiation. Almost a third of us will die of cancer anyway, mainly because we breathe air laden with that all pervasive carcinogen, oxygen.
In The Revenge of Gaia: Earth’s Climate Crisis & The Fate of Humanity (2006, 2007), 15.
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We need science education to produce scientists, but we need it equally to create literacy in the public. Man has a fundamental urge to comprehend the world about him, and science gives today the only world picture which we can consider as valid. It gives an understanding of the inside of the atom and of the whole universe, or the peculiar properties of the chemical substances and of the manner in which genes duplicate in biology. An educated layman can, of course, not contribute to science, but can enjoy and participate in many scientific discoveries which as constantly made. Such participation was quite common in the 19th century, but has unhappily declined. Literacy in science will enrich a person’s life.
In Popular Mechanics (Sep 1961), 256
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We speak erroneously of “artificial” materials, “synthetics”, and so forth. The basis for this erroneous terminology is the notion that Nature has made certain things which we call natural, and everything else is “man-made”, ergo artificial. But what one learns in chemistry is that Nature wrote all the rules of structuring; man does not invent chemical structuring rules; he only discovers the rules. All the chemist can do is find out what Nature permits, and any substances that are thus developed or discovered are inherently natural. It is very important to remember that.
From 'The Comprehensive Man', Ideas and Integrities: A Spontaneous Autobiographical Disclosure (1963), 75-76.
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We’re all living in a chemical soup.
Newsweek 7 Jan 85
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What chemists took from Dalton was not new experimental laws but a new way of practicing chemistry (he himself called it the “new system of chemical philosophy”), and this proved so rapidly fruitful that only a few of the older chemists in France and Britain were able to resist it.
The Structure of Scientific Revolutions (1962), 133.
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What is found in biology is mechanisms, mechanisms built with chemical components and that are often modified by other, later, mechanisms added to the earlier ones.
In What Mad Pursuit: A Personal View of Scientific Discovery (1988), 138.
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What made von Liebig and his students “different” from other chemists was their effort to apply their fundamental discoveries to the development of specific chemical processes and products.
In 'The Origins of Academic Chemical Engineering', collected in Nicholas A. Peppas (ed.), One Hundred Years of Chemical Engineering: From Lewis M. Norton (M.I.T. 1888) to Present (2012), 2.
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What others strive to see dimly and blindly, like bats in twilight, he [Petrus Peregrinus] gazes at in the full light of day, because he is a master of experiment. Through experiment he gains knowledge of natural things, medical, chemical, and indeed of everything in the heavens or earth. … He has even taken note of the remedies, lot casting, and charms used by old women and by wizards and magicians, and of the deceptions and devices of conjurors, so that nothing which deserves inquiry should escape him, and that he may be able to expose the falsehoods of magicians.
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What remains to be learned may indeed dwarf imagination. Nevertheless, the universe itself is closed and finite. … The uniformity of nature and the general applicability of natural laws set limits to knowledge. If there are just 100, or 105, or 110 ways in which atoms may form, then when one has identified the full range of properties of these, singly and in combination, chemical knowledge will be complete.
Presidential Address (28 Dec 1970) to the American Association for the Advancement of Science. 'Science: Endless Horizons or Golden Age?', Science (8 Jan 1971), 171, No. 3866, 24.
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What we call man is a mechanism made up of … uncrystallized matter … all the colloid matter of his mechanism is concentrated in a countless number of small cells. … [T]hese cells [are] dwelling places, communes, a walled town within which are many citizens. ... [T]hese are the units of life and when they pass out into space man as we think we know him is dead, a mere machine from which the crew have left,so to speak. ... [T]hese units are endowed with great intelligence. They have memories, they must be divided into countless thousands of groups, most are workers, there are directing groups. Some are chemists, they manufacture the most complicated chemicals that are secreted by the glands.
Diary and Sundry Observations of Thomas Alva Edison (1948), 203-44. In Mark Seltzer, Serial Killers (1998), 215-6.
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When Aloisio Galvani first stimulated the nervous fiber by the accidental contact of two heterogeneous metals, his contemporaries could never have anticipated that the action of the voltaic pile would discover to us, in the alkalies, metals of a silvery luster, so light as to swim on water, and eminently inflammable; or that it would become a powerful instrument of chemical analysis, and at the same time a thermoscope and a magnet.
In 'Introduction' Cosmos: A Sketch of a Physical Description of the Universe (1860), Vol. 1, 52, as translated by E.C. Otté.
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When carbon (C), Oxygen (o) and hydrogen (H) atoms bond in a certain way to form sugar, the resulting compound has a sweet taste. The sweetness resides neither in the C, nor in the O, nor in the H; it resides in the pattern that emerges from their interaction. It is an emergent property. Moreover, strictly speaking, is not a property of the chemical bonds. It is a sensory experience that arises when the sugar molecules interact with the chemistry of our taste buds, which in turns causes a set of neurons to fire in a certain way. The experience of sweetness emerges from that neural activity.
In The Hidden Connections (2002), 116-117.
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When chemists have brought their knowledge out of their special laboratories into the laboratory of the world, where chemical combinations are and have been through all time going on in such vast proportions,—when physicists study the laws of moisture, of clouds and storms, in past periods as well as in the present,—when, in short, geologists and zoologists are chemists and physicists, and vice versa,—then we shall learn more of the changes the world has undergone than is possible now that they are separately studied.
Geological Sketches (1866), 73.
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When one studies strongly radioactive substances special precautions must be taken if one wishes to be able to take delicate measurements. The various objects used in a chemical laboratory and those used in a chemical laboratory, and those which serve for experiments in physics, become radioactive in a short time and act upon photographic plates through black paper. Dust, the air of the room, and one’s clothes all become radioactive.
Notebook entry. In Eve Curie, Madame Curie: a Biography by Eve Curie (1937, 2007), 196.
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When scientists discovered that liquid water, which brought forth life on Earth, exists nowhere else in great quantities in the solar system, the most significant lesson they taught was not that water, or the life that depends on it, is necessarily the result of some chemical accident in space; their most important revelation was that water is rare in infinity, that we should prize it, preserve it, conserve it.
In Jacques Cousteau and Susan Schiefelbein, The Human, the Orchid, and the Octopus: Exploring and Conserving Our Natural World (2007), 201-202.
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When the formulae of inorganic chemical compounds are considered, even a superficial observer is struck with the general symmetry of their construction; the compounds of nitrogen, phosphorus, antimony and arsenic especially exhibit the tendency of the elements to form compounds containing 3 or 5 equivs. of other elements, and it is in these proportions that their affinities are best satisfied; thus in the ternal group we have NO3, NH3, NI3, NS3, PO3, PH3, PCl3, SbO3, SbH3, SbCl3, AsO3, AsH3, AsCl3 &c; and in the five-atom group NO4, NH4O, NH4I, PO5, PH4I, &c. Without offering any hypothesis regarding the cause of this symmetrical grouping of atoms, it is sufficiently evident, from the examples just given, that such a tendency or law prevails, and that, no matter what the character of the uniting atoms may be, the combining power of the attracting element, if I may be allowed the term, is always satisfied by the same number of these atoms.
'On a New Series of Organic Bodies Containing Metals', Philosophical Transactions of the Royal Society of London, 1852, 14:2, 440.
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When the simplest compounds of this element are considered (marsh gas, chloride of carbon, chloroform, carbonic acid, phosgene, sulphide of carbon, hydrocyanic acid, etc.) it is seen that the quantity of carbon which chemists have recognised as the smallest possible, that is, as an atom, always unites with 4 atoms of a monatomic or with two atoms of a diatomic element; that in general, the sum of the chemical units of the elements united with one atom of carbon is 4. This leads us to the view that carbon is tetratomic or tetrabasic. In the cases of substances which contain several atoms of carbon, it must be assumed that at least some of the atoms are in some way held in the compound by the affinity of carbon, and that the carbon atoms attach themselves to one another, whereby a part of the affinity of the one is naturally engaged with an equal part of the affinity of the other. The simplest and therefore the most probable case of such an association of carbon atoms is that in which one affinity unit of one is bound by one of the other. Of the 2 x 4 affinity units of the two carbon atoms, two are used up in holding the atoms together, and six remain over, which can be bound by atom)' of other elements.
'Ueber die Konstitution und die Metamorphosen der chemischen Verbindungen', Annalen (1858) 5, 106. Trans. in J. R. Partington, A History of Chemistry (1972), Vol. 4, 536.
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When we understand how animals are resistant to chemicals, the mechanisms are all independent of whether its natural or synthetic. And in fact, when you look at natural chemicals, half of those tested come out positive.
Paper to the American Chemical Society, 'Pollution, Pesticides and Cancer Misconceptions.' As cited by Art Drysdale, 'Latest Insider News: Natural vs. Synthetic Chemical Pesticides' (14 Feb 1999), on the mitosyfraudes.org website. Bruce Ames has written a similar sentiment in various other publications.
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Why should the leaders of chemical businesses be held responsible for polluting the marine environment with a few grams of effluent, which is sublethal to marine species, while celebrity chefs are turning out endangered fish at several dozen tables a night without enduring a syllable of criticism?
In The End of the Line: How Overfishing is Changing the World and what We Eat (2004), 189.
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Will it be possible to solve these problems? It is certain that nobody has thus far observed the transformation of dead into living matter, and for this reason we cannot form a definite plan for the solution of this problem of transformation. But we see that plants and animals during their growth continually transform dead into living matter, and that the chemical processes in living matter do not differ in principle from those in dead matter. There is, therefore, no reason to predict that abiogenesis is impossible, and I believe that it can only help science if the younger investigators realize that experimental abiogenesis is the goal of biology.
The Dynamics of Living Matter (1906), 223.
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With the tools and the knowledge, I could turn a developing snail's egg into an elephant. It is not so much a matter of chemicals because snails and elephants do not differ that much; it is a matter of timing the action of genes.
Quoted in Bruce Wallace, The Search for the Gene (1992), 176.
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Within a hundred years of physical and chemical science, men will know what the atom is. It is my belief when science reaches this stage, God will come down to earth with His big ring of keys and will say to humanity, 'Gentlemen, it is closing time.'
Quoted in Ralph Oesper, The Human Side of Scientists (1975), 17.
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Without some idea of oxidation processes, of the chemical structure of food, and of the chemical reactions in digestion, visceral behavior is a blank. And without some understanding of visceral behavior, psychic behavior is up in the air.
From Why We Behave Like Human Beings (1925), xiv.
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You have heard of the new chemical nomenclature endeavored to be introduced by Lavoisier, Fourcroy, &c. Other chemists of this country, of equal note, reject it, and prove in my opinion that it is premature, insufficient and false. These latter are joined by the British chemists; and upon the whole, I think the new nomenclature will be rejected, after doing more harm than good. There are some good publications in it, which must be translated into the ordinary chemical language before they will be useful.
Letter to Dr. Currie (Paris, 1788). In Thomas Jefferson and John P. Foley (ed.), The Jeffersonian Cyclopedia (1900), 135. From H.A. Washington, The Writings of Thomas Jefferson (1853-54). Vol 2, 544.
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Your remarks upon chemical notation with the variety of systems which have arisen, &c., &c., had almost stirred me up to regret publicly that such hindrances to the progress of science should exist. I cannot help thinking it a most unfortunate thing that men who as experimentalists & philosophers are the most fitted to advance the general cause of science & knowledge should by promulgation of their own theoretical views under the form of nomenclature, notation, or scale, actually retard its progress.
Letter to William Whewell (21 Feb 1831). In Isaac Todhunter, William Whewell, An Account of his Writings (1876), Vol. 1., 307. Faraday may have been referring to a paper by Whewell published in the Journal of the Royal Institution of England (1831), 437-453.
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Carl Sagan Thumbnail In science it often happens that scientists say, 'You know that's a really good argument; my position is mistaken,' and then they would actually change their minds and you never hear that old view from them again. They really do it. It doesn't happen as often as it should, because scientists are human and change is sometimes painful. But it happens every day. I cannot recall the last time something like that happened in politics or religion. (1987) -- Carl Sagan
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