'Normal' science, in Kuhn's sense, exists. It is the activity of the non-revolutionary, or more precisely, the not-too-critical professional: of the science student who accepts the ruling dogma of the day... in my view the 'normal' scientist, as Kuhn describes him, is a person one ought to be sorry for... He has been taught in a dogmatic spirit: he is a victim of indoctrination... I can only say that I see a very great danger in it and in the possibility of its becoming normal... a danger to science and, indeed, to our civilization. And this shows why I regard Kuhn's emphasis on the existence of this kind of science as so important.

“Science studies everything,” say the scientists. But, really, everything is too much. Everything is an infinite quantity of objects; it is impossible at one and the same time to study all. As a lantern cannot light up everything, but only lights up the place on which it is turned or the direction in which the man carrying it is walking, so also science cannot study everything, but inevitably only studies that to which its attention is directed. And as a lantern lights up most strongly the place nearest to it, and less and less strongly objects that are more and more remote from it, and does not at all light up those things its light does not reach, so also human science, of whatever kind, has always studied and still studies most carefully what seems most important to the investigators, less carefully what seems to them less important, and quite neglects the whole remaining infinite quantity of objects. ... But men of science to-day ... have formed for themselves a theory of “science for science's sake,” according to which science is to study not what mankind needs, but everything.

...the study of butterflies—creatures selected as the types of airiness and frivolity—instead of being despised, will some day be valued as one of the most important branches of Biological science.

[Question: What do you think was the most important physics idea to emerge this year?]
We won't know for a few years.

A poet is, after all, a sort of scientist, but engaged in a qualitative science in which nothing is measurable. He lives with data that cannot be numbered, and his experiments can be done only once. The information in a poem is, by definition, not reproducible. ... He becomes an equivalent of scientist, in the act of examining and sorting the things popping in [to his head], finding the marks of remote similarity, points of distant relationship, tiny irregularities that indicate that this one is really the same as that one over there only more important. Gauging the fit, he can meticulously place pieces of the universe together, in geometric configurations that are as beautiful and balanced as crystals.

A scientifically unimportant discovery is one which, however true and however interesting for other reasons, has no consequences for a system of theory with which scientists in that field are concerned.

All life is linked together in such a way that no part of the chain is unimportant. Frequently, upon the action of some of these minute beings depends the material success or failure of a great commonwealth.

An infinity of these tiny animals defoliate our plants, our trees, our fruits... they attack our houses, our fabrics, our furniture, our clothing, our furs ... He who in studying all the different species of insects that are injurious to us, would seek means of preventing them from harming us, would seek to cause them to perish, proposes for his goal important tasks indeed.

Analogy is a wonderful, useful and most important form of thinking, and biology is saturated with it. Nothing is worse than a horrible mass of undigested facts, and facts are indigestible unless there is some rhyme or reason to them. The physicist, with his facts, seeks reason; the biologist seeks something very much like rhyme, and rhyme is a kind of analogy.... This analogizing, this fine sweeping ability to see likenesses in the midst of differences is the great glory of biology, but biologists don't know it.... They have always been so fascinated and overawed by the superior prestige of exact physical science that they feel they have to imitate it.... In its central content, biology is not accurate thinking, but accurate observation and imaginative thinking, with great sweeping generalizations.

Any opinion as to the form in which the energy of gravitation exists in space is of great importance, and whoever can make his opinion probable will have, made an enormous stride in physical speculation. The apparent universality of gravitation, and the equality of its effects on matter of all kinds are most remarkable facts, hitherto without exception; but they are purely experimental facts, liable to be corrected by a single observed exception. We cannot conceive of matter with negative inertia or mass; but we see no way of accounting for the proportionality of gravitation to mass by any legitimate method of demonstration. If we can see the tails of comets fly off in the direction opposed to the sun with an accelerated velocity, and if we believe these tails to be matter and not optical illusions or mere tracks of vibrating disturbance, then we must admit a force in that direction, and we may establish that it is caused by the sun if it always depends upon his position and distance.

Art and religion first; then philosophy; lastly science. That is the order of the great subjects of life, that’s their order of importance.

As geology is essentially a historical science, the working method of the geologist resembles that of the historian. This makes the personality of the geologist of essential importance in the way he analyzes the past.

But the life of a man is of no greater importance to the universe than that of an oyster.

Considered as a mere question of physics, (and keeping all moral considerations entirely out of sight,) the appearance of man is a geological phenomenon of vast importance, indirectly modifying the whole surface of the earth, breaking in upon any supposition of zoological continuity, and utterly unaccounted for by what we have any right to call the laws of nature.

Darwin's book is very important and serves me as a basis in natural science for the class struggle in history. One has to put up with the crude English method of development, of course. Despite all deficiencies not only is the death-blow dealt here for the first time to 'teleology' in the natural sciences, but their rational meaning is empirically explained.

Doubtless many can recall certain books which have greatly influenced their lives, and in my own case one stands out especially—a translation of Hofmeister's epoch-making treatise on the comparative morphology of plants. This book, studied while an undergraduate at the University of Michigan, was undoubtedly the most important factor in determining the trend of my botanical investigation for many years.

Each generation has its few great mathematicians, and mathematics would not even notice the absence of the others. They are useful as teachers, and their research harms no one, but it is of no importance at all. A mathematician is great or he is nothing.

Even fairly good students, when they have obtained the solution of the problem and written down neatly the argument, shut their books and look for something else. Doing so, they miss an important and instructive phase of the work. ... A good teacher should understand and impress on his students the view that no problem whatever is completely exhausted.

Every time we get slapped down, we can say, Thank you Mother Nature, because it means we're about to learn something important.

For the sick it is important to have the best.

Frequently, I have been asked if an experiment I have planned is pure or applied science; to me it is more important to know if the experiment will yield new and probably enduring knowledge about nature. If it is likely to yield such knowledge, it is, in my opinion, good fundamental research; and this is more important than whether the motivation is purely aesthetic satisfaction on the part of the experimenter on the one hand or the improvement of the stability of a high-power transistor on the other.

He who works with the door open gets all kinds of interruptions, but he also occasionally gets clues as to what the world is and what might be important.

Here I shall present, without using Analysis [mathematics], the principles and general results of the Théorie, applying them to the most important questions of life, which are indeed, for the most part, only problems in probability. One may even say, strictly speaking, that almost all our knowledge is only probable; and in the small number of things that we are able to know with certainty, in the mathematical sciences themselves, the principal means of arriving at the truth—induction and analogy—are based on probabilities, so that the whole system of human knowledge is tied up with the theory set out in this essay.

I am convinced that an important stage of human thought will have been reached when the physiological and the psychological, the objective and the subjective, are actually united, when the tormenting conflicts or contradictions between my consciousness and my body will have been factually resolved or discarded.

I do not know if I am mistaken, but it seems that one can obtain more truths, important to Humanity, from Chemistry than from any other Science.

I had a dislike for [mathematics], and ... was hopelessly short in algebra. ... [One extraordinary teacher of mathematics] got the whole year's course into me in exactly six [after-school] lessons of half an hour each. And how? More accurately, why? Simply because he was an algebra fanatic—because he believed that algebra was not only a science of the utmost importance, but also one of the greatest fascination. ... [H]e convinced me in twenty minutes that ignorance of algebra was as calamitous, socially and intellectually, as ignorance of table manners—That acquiring its elements was as necessary as washing behind the ears. So I fell upon the book and gulped it voraciously. ... To this day I comprehend the binomial theorem.

I have always attached great importance to the manner in which an experiment is set up and conducted ... the experiment should be set up to open as many windows as possible on the unforeseen.

I must admit that when I chose the name, “vitamine,” I was well aware that these substances might later prove not to be of an amine nature. However, it was necessary for me to choose a name that would sound well and serve as a catchword, since I had already at that time no doubt about the importance and the future popularity of the new field.

I must consider the organizer as more important than the discoverer.

I thank God that I was not made a dexterous manipulator, for the most important of my discoveries have been suggested to me by my failures.

I would like to start by emphasizing the importance of surfaces. It is at a surface where many of our most interesting and useful phenomena occur. We live for example on the surface of a planet. It is at a surface where the catalysis of chemical reactions occur. It is essentially at a surface of a plant that sunlight is converted to a sugar. In electronics, most if not all active circuit elements involve non-equilibrium phenomena occurring at surfaces. Much of biology is concerned with reactions at a surface.

If the double helix was so important, how come you didn't work on It?
Ther husband, Linus Pauling, when the Nobel Prize was awarded to Crick, Watson and Wilkins.

If Watson and I had not discovered the [DNA] structure, instead of being revealed with a flourish it would have trickled out and that its impact would have been far less. For this sort of reason Stent had argued that a scientific discovery is more akin to a work of art than is generally admitted. Style, he argues, is as important as content. I am not completely convinced by this argument, at least in this case.

In my opinion the separation of the c- and ac-stars is the most important advancement in stellar classification since the trials by Vogel and Secchi ... To neglect the c-properties in classifying stellar spectra, I think, is nearly the same thing as if a zoologist, who has detected the deciding differences between a whale and a fish, would continue classifying them together.

In science the important thing is to modify and change one's ideas as science advances.

In studying the fate of our forest king, we have thus far considered the action of purely natural causes only; but, unfortunately, man is in the woods, and waste and pure destruction are making rapid headway. If the importance of the forests were even vaguely understood, even from an economic standpoint, their preservation would call forth the most watchful attention of government

In summary, very large populations may differentiate rapidly, but their sustained evolution will be at moderate or slow rates and will be mainly adaptive. Populations of intermediate size provide the best conditions for sustained progressive and branching evolution, adaptive in its main lines, but accompanied by inadaptive fluctuations, especially in characters of little selective importance. Small populations will be virtually incapable of differentiation or branching and will often be dominated by random inadaptive trends and peculiarly liable to extinction, but will be capable of the most rapid evolution as long as this is not cut short by extinction.

It is important that students bring a certain ragamuffin, barefoot irreverence to their studies; they are not here to worship what is known, but to question it.

It is more important to know the properties of chlorine than the improprieties of Claudius!

It is sometimes important for science to know how to forget the things she is surest of.

It is true that physics gives a wonderful training in precise, logical thinking-about physics. It really does depend upon accurate reproducible experiments, and upon framing hypotheses with the greatest possible freedom from dogmatic prejudice. And if these were the really important things in life, physics would be an essential study for everybody.

It is, however, a most astonishing but incontestable fact, that the history of the evolution of man as yet constitutes no part of general education. Indeed, our so-called “educated classes" are to this day in total ignorance of the most important circumstances and the most remarkable phenomena which Anthropogeny has brought to light.

Man is a little germ that lives on an unimportant rock ball that revolves about a small star at the outskirts of an ordinary galaxy. ... I am absolutely amazed to discover myself on this rock ball rotating around a spherical fire. It’s a very odd situation. And the more I look at things I cannot get rid of the feeling that existence is quite weird.

My original decision to devote myself to science was a direct result of the discovery which has never ceased to fill me with enthusiasm since my early youth—the comprehension of the far from obvious fact that the laws of human reasoning coincide with the laws governing the sequences of the impressions we receive from the world about us; that, therefore, pure reasoning can enable man to gain an insight into the mechanism of the latter. In this connection, it is of paramount importance that the outside world is something independent from man, something absolute, and the quest for the laws which apply to this absolute appeared to me as the most sublime scientific pursuit in life.

No organization engaged in any specific field of work ever invents any important developers in that field, or adopts any important development in that field until forced to do so by outside competition.

Often the great scientists, by turning the problem around a bit, changed a defect to an asset. For example, many scientists when they found they couldn't do a problem finally began to study why not. They then turned it around the other way and said, “But of course, this is what it is” and got an important result.

On the whole, I cannot help saying that it appears to me not a little extraordinary, that a theory so new, and of such importance, overturning every thing that was thought to be the best established in chemistry, should rest on so very narrow and precarious a foundation, the experiments adduced in support of it being not only ambiguous or explicable on either hypothesis, but exceedingly few. I think I have recited them all, and that on which the greatest stress is laid, viz. That of the formation of water from the decomposition of the two kinds of air, has not been sufficiently repeated. Indeed it required so difficult and expensive an apparatus, and so many precautions in the use of it, that the frequent repetition of the experiment cannot be expected; and in these circumstances the practised experimenter cannot help suspecting the accuracy of the result and consequently the certainty of the conclusion.

One hardly knows where, in the history of science, to look for an important movement that had its effective start in so pure and simple an accident as that which led to the building of the great Washington telescope, and went on to the discovery of the satellites of Mars.

One of the most striking results of modern investigation has been the way in which several different and quite independent lines of evidence indicate that a very great event occurred about two thousand million years ago. The radio-active evidence for the age of meteorites; and the estimated time for the tidal evolution of the Moon's orbit (though this is much rougher), all agree in their testimony, and, what is far more important, the red-shift in the nebulae indicates that this date is fundamental, not merely in the history of our system, but in that of the material universe as a whole.

Outside our consciousness there lies the cold and alien world of actual things. Between the two stretches the narrow borderland of the senses. No communication between the two worlds is possible excepting across the narrow strip. For a proper understanding of ourselves and of the world, it is of the highest importance that this borderland should be thoroughly explored.

Over the last century, physicists have used light quanta, electrons, alpha particles, X-rays, gamma-rays, protons, neutrons and exotic sub-nuclear particles for this purpose [scattering experiments]. Much important information about the target atoms or nuclei or their assemblage has been obtained in this way. In witness of this importance one can point to the unusual concentration of scattering enthusiasts among earlier Nobel Laureate physicists. One could say that physicists just love to perform or interpret scattering experiments.

Scientists, therefore, are responsible for their research, not only intellectually but also morally. This responsibility has become an important issue in many of today's sciences, but especially so in physics, in which the results of quantum mechanics and relativity theory have opened up two very different paths for physicists to pursue. They may lead us - to put it in extreme terms - to the Buddha or to the Bomb, and it is up to each of us to decide which path to take.

Since the seventeenth century, physical intuition has served as a vital source for mathematical porblems and methods. Recent trends and fashions have, however, weakened the connection between mathematics and physics; mathematicians, turning away from their roots of mathematics in intuition, have concentrated on refinement and emphasized the postulated side of mathematics, and at other times have overlooked the unity of their science with physics and other fields. In many cases, physicists have ceased to appreciate the attitudes of mathematicians. This rift is unquestionably a serious threat to science as a whole; the broad stream of scientific development may split into smaller and smaller rivulets and dry out. It seems therefore important to direct our efforts towards reuniting divergent trends by classifying the common features and interconnections of many distinct and diverse scientific facts.

That ability to impart knowledge ... what does it consist of? ... a deep belief in the interest and importance of the thing taught, a concern about it amounting to a sort of passion. A man who knows a subject thoroughly, a man so soaked in it that he eats it, sleeps it and dreams it—this man can always teach it with success, no matter how little he knows of technical pedagogy. That is because there is enthusiasm in him, and because enthusiasm is almost as contagious as fear or the barber's itch. An enthusiast is willing to go to any trouble to impart the glad news bubbling within him. He thinks that it is important and valuable for to know; given the slightest glow of interest in a pupil to start with, he will fan that glow to a flame. No hollow formalism cripples him and slows him down. He drags his best pupils along as fast as they can go, and he is so full of the thing that he never tires of expounding its elements to the dullest.
This passion, so unordered and yet so potent, explains the capacity for teaching that one frequently observes in scientific men of high attainments in their specialties—for example, Huxley, Ostwald, Karl Ludwig, Virchow, Billroth, Jowett, William G. Sumner, Halsted and Osler—men who knew nothing whatever about the so-called science of pedagogy, and would have derided its alleged principles if they had heard them stated.

The basis of the discovery is imagination, careful reasoning and experimentation where the use of knowledge created by those who came before is an important component.

The determination of the average man is not merely a matter of speculative curiosity; it may be of the most important service to the science of man and the social system. It ought necessarily to precede every other inquiry into social physics, since it is, as it were, the basis. The average man, indeed, is in a nation what the centre of gravity is in a body; it is by having that central point in view that we arrive at the apprehension of all the phenomena of equilibrium and motion.

The ends of scientific classification are best answered, when the objects are formed into groups respecting which a greater number of general propositions can be made, and those propositions more important, than could be made respecting any other groups into which the same things could be distributed. ... A classification thus formed is properly scientific or philosophical, and is commonly called a Natural, in contradistinction to a Technical or Artificial, classification or arrangement.

The fundamental biological variant is DNA. That is why Mendel's definition of the gene as the unvarying bearer of hereditary traits, its chemical identification by Avery (confirmed by Hershey), and the elucidation by Watson and Crick of the structural basis of its replicative invariance, are without any doubt the most important discoveries ever made in biology. To this must be added the theory of natural selection, whose certainty and full significance were established only by those later theories.

The inherent unpredictability of future scientific developments—the fact that no secure inference can be drawn from one state of science to another—has important implications for the issue of the limits of science. It means that present-day science cannot speak for future science: it is in principle impossible to make any secure inferences from the substance of science at one time about its substance at a significantly different time. The prospect of future scientific revolutions can never be precluded. We cannot say with unblinking confidence what sorts of resources and conceptions the science of the future will or will not use. Given that it is effectively impossible to predict the details of what future science will accomplish, it is no less impossible to predict in detail what future science will not accomplish. We can never confidently put this or that range of issues outside 'the limits of science', because we cannot discern the shape and substance of future science with sufficient clarity to be able to say with any assurance what it can and cannot do. Any attempt to set 'limits' to science—any advance specification of what science can and cannot do by way of handling problems and solving questions—is destined to come to grief.

The laws expressing the relations between energy and matter are, however, not solely of importance in pure science. They necessarily come first in order ... in the whole record of human experience, and they control, in the last resort, the rise or fall of political systems, the freedom or bondage of nations, the movements of commerce and industry, the origin of wealth and poverty, and the general physical welfare of the race.

The major credit I think Jim and I deserve ... is for selecting the right problem and sticking to it. It's true that by blundering about we stumbled on gold, but the fact remains that we were looking for gold. Both of us had decided, quite independently of each other, that the central problem in molecular biology was the chemical structure of the gene. ... We could not see what the answer was, but we considered it so important that we were determined to think about it long and hard, from any relevant point of view.

The meaning of human life and the destiny of man cannot be separable from the meaning and destiny of life in general. 'What is man?' is a special case of 'What is life?' Probably the human species is not intelligent enough to answer either question fully, but even such glimmerings as are within our powers must be precious to us. The extent to which we can hope to understand ourselves and to plan our future depends in some measure on our ability to read the riddles of the past. The present, for all its awesome importance to us who chance to dwell in it, is only a random point in the long flow of time. Terrestrial life is one and continuous in space and time. Any true comprehension of it requires the attempt to view it whole and not in the artificial limits of any one place or epoch. The processes of life can be adequately displayed only in the course of life throughout the long ages of its existence.

The most important and urgent problems of the technology of today are no longer the satisfactions of the primary needs or of archetypal wishes, but the reparation of the evils and damages by technology of yesterday.

The nature of light is a subject of no material importance to the concerns of life or to the practice of the arts, but it is in many other respects extremely interesting.

The nucleic acids, as constituents of living organisms, are comparable In importance to proteins. There is evidence that they are Involved In the processes of cell division and growth, that they participate In the transmission of hereditary characters, and that they are important constituents of viruses. An understanding of the molecular structure of the nucleic acids should be of value In the effort to understand the fundamental phenomena of life.
[Co-author with American chemist, B. Corey (1897-1971)]

The ocean's bottom is at least as important to us as the moon's behind.

The operating management, providing as it does for the care of near thirty thousand miles of railway, is far more important than that for construction in which there is comparatively little doing.

The progress of synthesis, or the building up of natural materials from their constituent elements, proceeds apace. Even some of the simpler albuminoids, a class of substances of great importance in the life process, have recently been artificially prepared. ... Innumerable entirely new compounds have been produced in the last century. The artificial dye-stuffs, prepared from materials occurring in coal-tar, make the natural colours blush. Saccharin, which is hundreds of times sweeter than sugar, is a purely artificial substance. New explosives, drugs, alloys, photographic substances, essences, scents, solvents, and detergents are being poured out in a continuous stream.

The relative importance of the white and gray matter is often misunderstood. Were it not for the manifold connection of the nerve cells in the cortex by the tens of millions of fibres which make up the under-estimated white matter, such a brain would be useless as a telephone or telegraph station with all the interconnecting wires destroyed.

The scientist, if he is to be more than a plodding gatherer of bits of information, needs to exercise an active imagination. The scientists of the past whom we now recognize as great are those who were gifted with transcendental imaginative powers, and the part played by the imaginative faculty of his daily life is as least as important for the scientist as it is for the worker in any other field—much more important than for most. A good scientist thinks logically and accurately when conditions call for logical and accurate thinking—but so does any other good worker when he has a sufficient number of well-founded facts to serve as the basis for the accurate, logical induction of generalizations and the subsequent deduction of consequences.

The smallest particles of matter were said [by Plato] to be right-angled triangles which, after combining in pairs, ... joined together into the regular bodies of solid geometry; cubes, tetrahedrons, octahedrons and icosahedrons. These four bodies were said to be the building blocks of the four elements, earth, fire, air and water ... [The] whole thing seemed to be wild speculation. ... Even so, I was enthralled by the idea that the smallest particles of matter must reduce to some mathematical form ... The most important result of it all, perhaps, was the conviction that, in order to interpret the material world we need to know something about its smallest parts.
[Recalling how as a teenager at school, he found Plato's Timaeus to be a memorable poetic and beautiful view of atoms.]

The velocity of light is one of the most important of the fundamental constants of Nature. Its measurement by Foucault and Fizeau gave as the result a speed greater in air than in water, thus deciding in favor of the undulatory and against the corpuscular theory. Again, the comparison of the electrostatic and the electromagnetic units gives as an experimental result a value remarkably close to the velocity of light–a result which justified Maxwell in concluding that light is the propagation of an electromagnetic disturbance. Finally, the principle of relativity gives the velocity of light a still greater importance, since one of its fundamental postulates is the constancy of this velocity under all possible conditions.

The works which this man [Joseph Banks] leaves behind him occupy a few pages only; their importance is not greatly superior to their extent; and yet his name will shine out with lustre in the history of the sciences.

The year 1896 ... marked the beginning of what has been aptly termed the heroic age of Physical Science. Never before in the history of physics has there been witnessed such a period of intense activity when discoveries of fundamental importance have followed one another with such bewildering rapidity.

These microscopic organisms form an entire world composed of species, families and varieties whose history, which has barely begun to be written, is already fertile in prospects and findings of the highest importance. The names of these organisms are very numerous and will have to be defined and in part discarded. The word microbe which has the advantage of being shorter and carrying a more general meaning, and of having been approved by my illustrious friend, M. Littré, the most competent linguist in France, is one we will adopt.

Think of a single problem confronting the world today. Disease, poverty, global warming… If the problem is going to be solved, it is science that is going to solve it. Scientists tend to be unappreciated in the world at large, but you can hardly overstate the importance of the work they do. If anyone ever cures cancer, it will be a guy with a science degree. Or a woman with a science degree.

This missing science of heredity, this unworked mine of knowledge on the borderland of biology and anthropology, which for all practical purposes is as unworked now as it was in the days of Plato, is, in simple truth, ten times more important to humanity than all the chemistry and physics, all the technical and indsutrial science that ever has been or ever will be discovered.

To teach effectively a teacher must develop a feeling for his subject; he cannot make his students sense its vitality if he does not sense it himself. He cannot share his enthusiasm when he has no enthusiasm to share. How he makes his point may be as important as the point he makes; he must personally feel it to be important.

Uniformity in the currency, weights, and measures of the United States is an object of great importance, and will, I am persuaded, be duly attended to.

When going ahead in space, it is also important to go back in time.

[Anning is] probably the most important unsung (or inadequately sung) collecting force in the history of paleontology.

[Magic] enables man to carry out with confidence his important tasks, to maintain his poise and his mental integrity in fits of anger, in the throes of hate, of unrequited love, of despair and anxiety. The function of magic is to ritualize man's optimism, to enhance his faith in the victory of hope over fear. Magic expresses the greater value for man of confidence over doubt, of steadfastness over vacillation, of optimism over pessimism.

[Otto Struve] made the remark once that he never looked at the spectrum of a star, any star, where he didn’t find something important to work on.

[Penguins] are extraordinarily like children, these little people of the Antarctic world, either like children, or like old men, full of their own importance and late for dinner, in their black tail-coats and white shirt-fronts — and rather portly withal.

[Science] is the literature of God written on the stars—the trees—the rocks—and more important because [of] its marked utilitarian character.