...what is man in the midst of nature? A nothing in comparison with the infinite, an all in comparison with nothingness: a mean between nothing and all. Infinitely far from comprehending the extremes, the end of things and their principle are for him inevitably concealed in an impenetrable secret; equally incapable of seeing the nothingness whence he is derived, and the infinity in which he is swallowed up.

Question: If you were to pour a pound of molten lead and a pound of molten iron, each at the temperature of its melting point, upon two blocks of ice, which would melt the most ice, and why?
Answer: This question relates to diathermancy. Iron is said to be a diathermanous body (from dia, through, and thermo, I heat), meaning that it gets heated through and through, and accordingly contains a large quantity of real heat. Lead is said to be an athermanous body (from a, privative, and thermo, I heat), meaning that it gets heated secretly or in a latent manner. Hence the answer to this question depends on which will get the best of it, the real heat of the iron or the latent heat of the lead. Probably the iron will smite furthest into the ice, as molten iron is white and glowing, while melted lead is dull.

At lunch Francis [Crick] winged into the Eagle to tell everyone within hearing distance that we had found the secret of life.

But why, it has been asked, did you go there [the Antarctic]? Of what use to civilization can this lifeless continent be? ... [Earlier] expeditions contributed something to the accumulating knowledge of the Antarctic ... that helps us thrust back further the physical and spiritual shadows enfolding our terrestrial existence. Is it not true that one of the strongest and most continuously sustained impulses working in civilization is that which leads to discovery? As long as any part of the world remains obscure, the curiosity of man must draw him there, as the lodestone draws the mariner's needle, until he comprehends its secret.

From my close observation of writers ... they fall in to two groups: 1) those who bleed copiously and visibly at any bad review, and 2) those who bleed copiously and secretly at any bad review.

From the age of 13, I was attracted to physics and mathematics. My interest in these subjects derived mostly from popular science books that I read avidly. Early on I was fascinated by theoretical physics and determined to become a theoretical physicist. I had no real idea what that meant, but it seemed incredibly exciting to spend one's life attempting to find the secrets of the universe by using one's mind.

God put a secret art into the forces of Nature so as to enable it to fashion itself out of chaos into a perfect world system.

I have often admired the mystical way of Pythagoras, and the secret magick of numbers.

In nature's infinite book of secrecy
A little I can read.

It is unlikely that we will ever see a star being born. Stars are like animals in the wild. We may see the very young, but never their actual birth, which is a veiled and secret event. Stars are born inside thick clouds of dust and gas in the spiral arms of the galaxy, so thick that visible light cannot penetrate them.

Magic and all that is ascribed to it is a deep presentiment of the powers of science. The shoes of swiftness, the sword of sharpness, the power of subduing the elements, of using the secret virtues of minerals, of understanding the voices of birds, are the obscure efforts of the mind in a right direction.

My scientific work is motivated by an irresistible longing to understand the secrets of nature and by no other feeling. My love for justice and striving to contribute towards the improvement of human conditions are quite independent from my scientific interests.

Newton was not the first of the age of reason. He was the last of the magicians, the last of the Babylonians and Sumerians ... Isaac Newton, a posthumous child born with no father on Christmas Day, 1642, was the last wonder child to whom the Magi could do sincere and appropriate homage... Why do I call him a magician? Because he looked on the whole universe and all that is in it as a riddle, as a secret which could be read by applying pure thought to certain evidence, certain mystic clues which God had laid about the world to allow a sort of philosopher's treasure hunt to the esoteric brotherhood... He regarded the Universe as a cryptogram set by the Almighty—just as he himself wrapt the discovery of the calculus in a cryptogram when he communicated with Leibniz. By pure thought, by concentration of mind, the riddle, he believed, would be revealed to the initiate.

Only by following out the injunction of our great predecessor [William Harvey] to search out and study the secrets of Nature by way of experiment, can we hope to attain to a comprehension of 'the wisdom of the body and the understanding of the heart,' and thereby to the mastery of disease and pain, which will enable us to relieve the burden of mankind.

Putting together the mysteries of nature with the laws of mathematics, he dared to hope to be able to unlock the secrets of both with the same key.
Epitaph of René Descartes

So-called extraordinary events always split into two extremes naturalists who have not witnessed them: those who believe blindly and those who do not believe at all. The latter have always in mind the story of the golden goose; if the facts lie slightly beyond the limits of their knowledge, they relegate them immediately to fables. The former have a secret taste for marvels because they seem to expand Nature; they use their imagination with pleasure to find explanations. To remain doubtful is given to naturalists who keep a middle path between the two extremes. They calmly examine facts; they refer to logic for help; they discuss probabilities; they do not scoff at anything, not even errors, because they serve at least the history of the human mind; finally, they report rather than judge; they rarely decide unless they have good evidence.

The end of our foundation [Salomon's House in the New Atlantis] is the knowledge of Causes and the secret motions of things; and the enlarging of the bounds of Human Empire, to the effecting of all things possible.

The Europeans and the Americans are not throwing $10 billion down this gigantic tube for nothing. We're exploring the very forefront of physics and cosmology with the Large Hadron Collider because we want to have a window on creation, we want to recreate a tiny piece of Genesis to unlock some of the greatest secrets of the universe.

The fascination of any search after truth lies not in the attainment, which at best is found to be very relative, but in the pursuit, where all the powers of the mind and character are brought into play and are absorbed by the task. One feels oneself in contact with something that is infinite and one finds joy that is beyond expression in sounding the abyss of science and the secrets of the infinite mind.

The most heated defenders of a science, who cannot endure the slightest sneer at it, are commonly those who have not made very much progress in it and are secretly aware of this defect.

The open secret of real success is to throw your whole personality into your problem.

The secrets of evolution are death and time—the deaths of enormous numbers of lifeforms that were imperfectly adapted to the environment; and time for a long succession of small mutations.

The value the world sets upon motives is often grossly unjust and inaccurate. Consider, for example, two of them: mere insatiable curiosity and the desire to do good. The latter is put high above the former, and yet it is the former that moves some of the greatest men the human race has yet produced: the scientific investigators. What animates a great pathologist? Is it the desire to cure disease, to save life? Surely not, save perhaps as an afterthought. He is too intelligent, deep down in his soul, to see anything praiseworthy in such a desire. He knows by life-long observation that his discoveries will do quite as much harm as good, that a thousand scoundrels will profit to every honest man, that the folks who most deserve to be saved will probably be the last to be saved. No man of self-respect could devote himself to pathology on such terms. What actually moves him is his unquenchable curiosity–his boundless, almost pathological thirst to penetrate the unknown, to uncover the secret, to find out what has not been found out before. His prototype is not the liberator releasing slaves, the good Samaritan lifting up the fallen, but the dog sniffing tremendously at an infinite series of rat-holes.

The year that Rutherford died (1938 [sic]) there disappeared forever the happy days of free scientific work which gave us such delight in our youth. Science has lost her freedom. Science has become a productive force. She has become rich but she has become enslaved and part of her is veiled in secrecy. I do not know whether Rutherford would continue to joke and laugh as he used to.

This revelation of the secrets of nature, long mercifully withheld from man, should arouse the most solemn reflections in the mind and conscience of every human being capable of comprehension. We must indeed pray that these awful agencies will be made to conduce to peace among the nations, and that instead of wreaking measureless havoc upon the entire globe, may become a perennial fountain of world prosperity.
[Concerning use of the atomic bomb.]

We are always chasing after things that other companies won't touch. That is a big secret to our success.
[About Sony, 1998]

We do not ask for what useful purpose the birds do sing, for song is their pleasure since they were created for singing. Similarly, we ought not to ask why the human mind troubles to fathom the secrets of the heavens ... The diversity of the phenomena of Nature is so great, and the treasures hidden in the heavens so rich, precisely in order that the human mind shall never be lacking in fresh nourishment.

We do not ask what hope of gain makes a little bird warble, since we know that it takes delight in singing because it is for that very singing that the bird was made, so there is no need to ask why the human mind undertakes such toil in seeking out these secrets of the heavens. ... And just as other animals, and the human body, are sustained by food and drink, so the very spirit of Man, which is something distinct from Man, is nourished, is increased, and in a sense grows up on this diet of knowledge, and is more like the dead than the living if it is touched by no desire for these things.

What animates a great pathologist? Is it the desire to cure disease, to save life? Surely not, save perhaps as an afterthought. He is too intelligent, deep in his soul, to see anything praiseworthy in such a desire. He knows from life-long observation that his discoveries will do quite as much harm as good, that a thousand scoundrels will profit to every honest man, that the folks who most deserve to be saved will probably be the last to be saved. ... What actually moves him is his unquenchable curiosity—his boundless, almost pathological thirst to penetrate the unknown, to uncover the secret, to find out what has not been found out before. ... [like] the dog sniffing tremendously at an infinite series of rat-holes. ... And yet he stands in the very front rank of the race

What is a scientist?… We give the name scientist to the type of man who has felt experiment to be a means guiding him to search out the deep truth of life, to lift a veil from its fascinating secrets, and who, in this pursuit, has felt arising within him a love for the mysteries of nature, so passionate as to annihilate the thought of himself.

What's the best part of being a mathematician? I'm not a religious man, but it's almost like being in touch with God when you're thinking about mathematics. God is keeping secrets from us, and it's fun to try to learn some of the secrets.

While Newton seemed to draw off the veil from some of the mysteries of nature, he showed at the same time the imperfections of the mechanical philosophy; and thereby restored her ultimate secrets to that obscurity, in which they ever did and ever will remain.

[On the practical applications of particle physics research with the Large Hadron Collider.] Sometimes the public says, 'What's in it for Numero Uno? Am I going to get better television reception? Am I going to get better Internet reception?' Well, in some sense, yeah. ... All the wonders of quantum physics were learned basically from looking at atom-smasher technology. ... But let me let you in on a secret: We physicists are not driven to do this because of better color television. ... That's a spin-off. We do this because we want to understand our role and our place in the universe.