A man who is all theory is like “a rudderless ship on a shoreless sea.” ... Theories and speculations may be indulged in with safety only as long as they are based on facts that we can go back to at all times and know that we are on solid ground.

Any opinion as to the form in which the energy of gravitation exists in space is of great importance, and whoever can make his opinion probable will have, made an enormous stride in physical speculation. The apparent universality of gravitation, and the equality of its effects on matter of all kinds are most remarkable facts, hitherto without exception; but they are purely experimental facts, liable to be corrected by a single observed exception. We cannot conceive of matter with negative inertia or mass; but we see no way of accounting for the proportionality of gravitation to mass by any legitimate method of demonstration. If we can see the tails of comets fly off in the direction opposed to the sun with an accelerated velocity, and if we believe these tails to be matter and not optical illusions or mere tracks of vibrating disturbance, then we must admit a force in that direction, and we may establish that it is caused by the sun if it always depends upon his position and distance.

As he sat alone in a garden, he [Isaac Newton in 1666, age 24] fell into a speculation on the power of gravity; that as this power is not found sensibly diminished at the remotest distance from the centre of the earth to which we can rise, neither at the tops of the loftiest buildings, nor even on the summits of the highest mountains, it appeared to him reasonable to conclude that this power must extend much further than was usually thought: why not as high as the moon? said he to himself; and if so, her motion must be influenced by it; perhaps she is retained in her orbit thereby.

Astronomers and physicists, dealing habitually with objects and quantities far beyond the reach of the senses, even with the aid of the most powerful aids that ingenuity has been able to devise, tend almost inevitably to fall into the ways of thinking of men dealing with objects and quantities that do not exist at all, e.g., theologians and metaphysicians. Thus their speculations tend almost inevitably to depart from the field of true science, which is that of precise observation, and to become mere soaring in the empyrean. The process works backward, too. That is to say, their reports of what they pretend actually to see are often very unreliable. It is thus no wonder that, of all men of science, they are the most given to flirting with theology. Nor is it remarkable that, in the popular belief, most astronomers end by losing their minds.

By no amount of reasoning can we altogether eliminate all contingency from our world. Moreover, pure speculation alone will not enable us to get a determinate picture of the existing world. We must eliminate some of the conflicting possibilities, and this can be brought about only by experiment and observation.

Geology differs as widely from cosmogony, as speculations concerning the creation of man differ from history.

I also ask you my friends not to condemn me entirely to the mill of mathematical calculations, and allow me time for philosophical speculations, my only pleasures.

I am a firm believer, that without speculation there is no good & original observation.

I have read various articles on the fourth dimension, the relativity theory of Einstein, and other psychological speculation on the constitution of the universe; and after reading them I feel as Senator Brandegee felt after a celebrated dinner in Washington. "I feel," he said, "as if I had been wandering with Alice in Wonderland and had tea with the Mad Hatter."

I venture to maintain, that, if the general culture obtained in the Faculty of Arts were what it ought to be, the student would have quite as much knowledge of the fundamental principles of Physics, of Chemistry, and of Biology, as he needs, before he commenced his special medical studies. Moreover, I would urge, that a thorough study of Human Physiology is, in itself, an education broader and more comprehensive than much that passes under that name. There is no side of the intellect which it does not call into play, no region of human knowledge into which either its roots, or its branches, do not extend; like the Atlantic between the Old and the New Worlds, its waves wash the shores of the two worlds of matter and of mind; its tributary streams flow from both; through its waters, as yet unfurrowed by the keel of any Columbus, lies the road, if such there be, from the one to the other; far away from that Northwest Passage of mere speculation, in which so many brave souls have been hopelessly frozen up.

In all speculations on the origin, or agents that have produced the changes on this globe, it is probable that we ought to keep within the boundaries of the probable effects resulting from the regular operations of the great laws of nature which our experience and observation have brought within the sphere of our knowledge. When we overleap those limits, and suppose a total change in nature's laws, we embark on the sea of uncertainty, where one conjecture is perhaps as probable as another; for none of them can have any support, or derive any authority from the practical facts wherewith our experience has brought us acquainted.

In the last two months I have been very busy with my own mathematical speculations, which have cost me much time, without my having reached my original goal. Again and again I was enticed by the frequently interesting prospects from one direction to the other, sometimes even by will-o'-the-wisps, as is not rare in mathematic speculations.

It always bothers me that according to the laws as we understand them today, it takes a computing machine an infinite number of logical operations to figure out what goes on in no matter how tiny a region of space and no matter how tiny a region of time ... I have often made the hypothesis that ultimately physics will not require a mathematical statement, that in the end the machinery will be revealed and the laws will turn out to be simple. ... But this speculation is of the same nature as those other people make - 'I like it','I don't like it' - and it is not good to be too prejudiced about these things.

It is not always the most brilliant speculations nor the choice of the most exotic materials that is most profitable. I prefer Monsieur de Reaumur busy exterminating moths by means of an oily fleece; or increasing fowl production by making them hatch without the help of their mothers, than Monsieur Bemouilli absorbed in algebra, or Monsieur Leibniz calculating the various advantages and disadvantages of the possible worlds.

Medicine has been defined to be the art or science of amusing a sick man with frivolous speculations about his disorder, and of tampering ingeniously, till nature either kills or cures him.

My final remark to young women and men going into experimental science is that they should pay little attention to the speculative physics ideas of my generation. After all, if my generation has any really good speculative ideas, we will be carrying these ideas out ourselves.

No branches of historical inquiry have suffered more from fanciful speculation than those which relate to the origin and attributes of the races of mankind. The differentiation of these races began in prehistoric darkness, and the more obscure a subject is, so much the more fascinating. Hypotheses are tempting, because though it may be impossible to verify them, it is, in the paucity of data, almost equally impossible to refute them.

Not only did he teach by accomplishment, but he taught by the inspiration of a marvelous imagination that refused to accept the permanence of what appeared to others to be insuperable difficulties: an imagination of the goals of which, in a number of instances, are still in the realms of speculation.

Now that we locate them [genes] in the chromosomes are we justified in regarding them as material units; as chemical bodies of a higher order than molecules? Frankly, these are questions with which the working geneticist has not much concern himself, except now and then to speculate as to the nature of the postulated elements. There is no consensus of opinion amongst geneticists as to what the genes are—whether they are real or purely fictitious—because at the level at which the genetic experiments lie, it does not make the slightest difference whether the gene is a hypothetical unit, or whether the gene is a material particle. In either case the unit is associated with a specific chromosome, and can be localized there by purely genetic analysis. Hence, if the gene is a material unit, it is a piece of chromosome; if it is a fictitious unit, it must be referred to a definite location in a chromosome—the same place as on the other hypothesis. Therefore, it makes no difference in the actual work in genetics which point of view is taken. Between the characters that are used by the geneticist and the genes that his theory postulates lies the whole field of embryonic development.

Of all regions of the earth none invites speculation more than that which lies beneath our feet, and in none is speculation more dangerous; yet, apart from speculation, it is little that we can say regarding the constitution of the interior of the earth. We know, with sufficient accuracy for most purposes, its size and shape: we know that its mean density is about 5½ times that of water, that the density must increase towards the centre, and that the temperature must be high, but beyond these facts little can be said to be known. Many theories of the earth have been propounded at different times: the central substance of the earth has been supposed to be fiery, fluid, solid, and gaseous in turn, till geologists have turned in despair from the subject, and become inclined to confine their attention to the outermost crust of the earth, leaving its centre as a playground for mathematicians.

Philosophy is regarded by many as inseparable from speculation. ... Philosophy has proceeded from speculation to science.

Realizing how often ingenious speculation in the complex biological world has led nowhere and how often the real advances in biology as well as in chemistry, physics and astronomy have kept within the bounds of mechanistic interpretation, we geneticists should rejoice, even with our noses on the grindstone (which means both eyes on the objectives), that we have at command an additional means of testing whatever original ideas pop into our heads.

Speculations apparently the most unprofitable have almost invariably been those from which the greatest practical applications have emanated.

Surgical knowledge depends on long practice, not from speculations.

The determination of the average man is not merely a matter of speculative curiosity; it may be of the most important service to the science of man and the social system. It ought necessarily to precede every other inquiry into social physics, since it is, as it were, the basis. The average man, indeed, is in a nation what the centre of gravity is in a body; it is by having that central point in view that we arrive at the apprehension of all the phenomena of equilibrium and motion.

The end of knowledge is power ... the scope of all speculation is the performing of some action or thing to be done.

The history of this paper suggests that highly speculative investigations, especially by an unknown author, are best brought before the world through some other channel than a scientific society, which naturally hesitates to admit into its printed records matters of uncertain value. Perhaps one may go further and say that a young author who believes himself capable of great things would usually do well to secure the favourable recognition of the scientific world by work whose scope is limited and whose value is easily judged, before embarking upon higher flights.

The publication of the Darwin and Wallace papers in 1858, and still more that of the 'Origin' in 1859, had the effect upon them of the flash of light, which to a man who has lost himself in a dark night, suddenly reveals a road which, whether it takes him straight home or not, certainly goes his way. That which we were looking for, and could not find, was a hypothesis respecting the origin of known organic forms, which assumed the operation of no causes but such as could be proved to be actually at work. We wanted, not to pin our faith to that or any other speculation, but to get hold of clear and definite conceptions which could be brought face to face with facts and have their validity tested. The 'Origin' provided us with the working hypothesis we sought.

The smallest particles of matter were said [by Plato] to be right-angled triangles which, after combining in pairs, ... joined together into the regular bodies of solid geometry; cubes, tetrahedrons, octahedrons and icosahedrons. These four bodies were said to be the building blocks of the four elements, earth, fire, air and water ... [The] whole thing seemed to be wild speculation. ... Even so, I was enthralled by the idea that the smallest particles of matter must reduce to some mathematical form ... The most important result of it all, perhaps, was the conviction that, in order to interpret the material world we need to know something about its smallest parts.
[Recalling how as a teenager at school, he found Plato's Timaeus to be a memorable poetic and beautiful view of atoms.]

The strongest arguments prove nothing so long as the conclusions are not verified by experience. Experimental science is the queen of sciences and the goal of all speculation.

The vortex theory [of the atom] is only a dream. Itself unproven, it can prove nothing, and any speculations founded upon it are mere dreams about dreams.

Thus science strips off, one after the other, the more or less gross materialisations by which we endeavour to form an objective image of the soul, till men of science, speculating, in their non-scientific intervals, like other men on what science may possibly lead to, have prophesied that we shall soon have to confess that the soul is nothing else than a function of certain complex material systems.

Where any answer is possible, all answers are meaningless.
[Referring to speculations (on 'Not as We Know It' alien lifeforms) made in the total absence of evidence.]

Why speculate when you can calculate?

With increasing distance, our knowledge fades, and fades rapidly. Eventually, we reach the dim boundary—the utmost limits of our telescopes. There, we measure shadows, and we search among ghostly errors of measurement for landmarks that are scarcely more substantial. The search will continue. Not until the empirical resources are exhausted, need we pass on to the dreamy realms of speculation.

“In the beginning... rdquo; Whatever our speculations may be in regard to a “beginning,” and when it was, it is written in the rocks that, like the animals and plants ... , the earth itself grew.