It hurts the spirit, somehow, to read the word environments, when the plural means that there are so many alternatives there to be sorted through, as in a market, and voted on.

Language is simply alive, like an organism. We all tell each other this, in fact, when we speak of living languages, and I think we mean something more than an abstract metaphor. We mean alive. Words are the cells of language, moving the great body, on legs. Language grows and evolves, leaving fossils behind. The individual words are like different species of animals. Mutations occur. Words fuse, and then mate. Hybrid words and wild varieties or compound words are the progeny. Some mixed words are dominated by one parent while the other is recessive. The way a word is used this year is its phenotype, but it has deeply immutable meanings, often hidden, which is its genotype.... The separate languages of the Indo-European family were at one time, perhaps five thousand years ago, maybe much longer, a single language. The separation of the speakers by migrations had effects on language comparable to the speciation observed by Darwin on various islands of the Galapagos. Languages became different species, retaining enough resemblance to an original ancestor so that the family resemblance can still be seen.

Mistakes are at the very base of human thought feeding the structure like root nodules. If we were not provided with the knack of being wrong, we could never get anything useful done.

Sometimes you get a glimpse of a semicolon coming, a few lines farther on, and it is like climbing a steep path through woods and seeing a wooden bench just at a bend in the road ahead, a place where you can expect to sit for a moment, catching your breath.

The act of smelling something, anything, is remarkably like the act of thinking. Immediately at the moment of perception, you can feel the mind going to work, sending the odor around from place to place, setting off complex repertories through the brain, polling one center after another for signs of recognition, for old memories and old connection.

The capacity to blunder slightly is the real marvel of DNA. Without this special attribute, we would still be anaerobic bacteria and there would be no music.

The only solid piece of scientific truth about which I feel totally confident is that we are profoundly ignorant about nature... It is this sudden confrontation with the depth and scope of ignorance that represents the most significant contribution of twentieth-century science to the human intellect.

The uniformity of earth's life, more astonishing than its diversity, is accountable by the high probability that we derived, originally, from some single cell, fertilized in a bolt of lightning as the earth cooled.

This is the element that distinguishes applied science from basic. Surprise is what makes the difference. When you are organized to apply knowledge, set up targets, produce a usable product, you require a high degree of certainty from the outset. All the facts on which you base protocols must be reasonably hard facts with unambiguous meaning. The challenge is to plan the work and organize the workers so that it will come out precisely as predicted. For this, you need centralized authority, elaborately detailed time schedules, and some sort of reward system based on speed and perfection. But most of all you need the intelligible basic facts to begin with, and these must come from basic research. There is no other source. In basic research, everything is just the opposite. What you need at the outset is a high degree of uncertainty; otherwise it isn't likely to be an important problem. You start with an incomplete roster of facts, characterized by their ambiguity; often the problem consists of discovering the connections between unrelated pieces of information. You must plan experiments on the basis of probability, even bare possibility, rather than certainty.

We are a spectacular, splendid manifestation of life. We have language. . . . We have affection. We have genes for usefulness, and usefulness is about as close to a 'common goal' of nature as I can guess at.

We are built to make mistakes, coded for error.

We are, perhaps, uniquely among the earth's creatures, the worrying animal. We worry away our lives, fearing the future, discontent with the present, unable to take in the idea of dying, unable to sit still.

We pass the word around; we ponder how the case is put by different people, we read the poetry; we meditate over the literature; we play the music; we change our minds; we reach an understanding. Society evolves this way . . .