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If you’re too sloppy, then you never get reproducible results, and then you never can draw any conclusions; but if you are just a little sloppy, then when you see something startling, you say, “Oh, my God, what did I do, what did I do different this time?” And if you really accidentally varied only one parameter, you nail it down, and that’s exactly what happened [to produce new experimental discoveries]. So I called it the "Principle of Limited Sloppiness".
From Interview (1978) for Oral History Project, California Institute of Technology Archives, Pasadena, California (oralhistories.library.caltech.edu), Online PDF version, 76-77. Delbrück also stated he first made a casual remark about the “Principle of Limited Sloppiness” as chairman at a meeting in Oak Ridge after the war.

In science it often happens that scientists say, 'You know that's a really good argument; my position is mistaken,' and then they would actually change their minds and you never hear that old view from them again. They really do it. It doesn't happen as often as it should, because scientists are human and change is sometimes painful. But it happens every day. I cannot recall the last time something like that happened in politics or religion.
(1987) --
Carl Sagan
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