... an analysis that puts the final link in the chain, for here we see correlations between cytological evidence and genetic results that are so strong and obvious that their validity cannot be denied. This paper has been called a landmark in experimental genetics. It is more than that—it is a cornerstone.
Describing the paper 'A Correlation of Cytological and Genetic Crossings-over in Zea mays' published by Barbara McClintock and her student Harriet Creighton in the Proceedings of the National Academy of Sciences (1931), demonstrating that the exchange of genetic information that occurs during the production of sex cells is accompanied by an exchange of chromosomal material.

... I left Caen, where I was living, to go on a geologic excursion under the auspices of the School of Mines. The incidents of the travel made me forget my mathematical work. Having reached Coutances, we entered an omnibus to go to some place or other. At the moment when I put my foot on the step, the idea came to me, without anything in my former thoughts seeming to have paved the way for it, that the transformations I had used to define the Fuchsian functions were identical with those of non-Eudidean geometry. I did not verify the idea; I should not have had time, as upon taking my seat in the omnibus, I went on with a conversation already commenced, but I felt a perfect certainty. On my return to Caen, for convenience sake, I verified the result at my leisure.

… the three positive characteristics that distinguish mathematical knowledge from other knowledge … may be briefly expressed as follows: first, mathematical knowledge bears more distinctly the imprint of truth on all its results than any other kind of knowledge; secondly, it is always a sure preliminary step to the attainment of other correct knowledge; thirdly, it has no need of other knowledge.

...I believe there exists, & I feel within me, an instinct for the truth, or knowledge or discovery, of something of the same nature as the instinct of virtue, & that our having such an instinct is reason enough for scientific researches without any practical results ever ensuing from them.

...the genes almost always accurately reproduce. If they don't, you get one of the following results: One, monsters—that is, grossly malformed babies resulting from genetic mistakes. Years ago most monsters died, but now many can be saved. This has made possible the National Football League.

...the life of the planet began the long, slow process of modulating and regulating the physical conditions of the planet. The oxygen in today's atmosphere is almost entirely the result of photosynthetic living, which had its start with the appearance of blue-green algae among the microorganisms.

“Going fishing!” How often the question has been asked by acquaintances, as they have met me, with rod and basket, on an excursion after materials for microscopic study. “Yes!” has been the invariable answer, for it saved much detention and explanation; and now, behold! I offer them the results of that fishing. No fish for the stomach, but, as the old French microscopist Joblet observed, “some of the most remarkable fishes that have ever been seen”; and food-fishes for the intellect.

“Heaven helps those who help themselves” is a well-tried maxim, embodying in a small compass the results of vast human experience. The spirit of self-help is the root of all genuine growth in the individual; and, exhibited in the lives of many, it constitutes the true source of national vigour and strength. Help from without is often enfeebling in its effects, but help from within invariably invigorates. Whatever is done for men or classes, to a certain extent takes away the stimulus and necessity of doing for themselves; and where men are subjected to over-guidance and over-government, the inevitable tendency is to render them comparatively helpless.

“Planning” is simply the result of experience read backward and projected into the future. To me the “purposive” action of a beehive is simply the summation and integration of its units, and Natural Selection has put higher and higher premiums on the most “purposeful” integration. It is the same way (to me) in the evolution of the middle ear, the steps in the Cynodonts (clearly shown by me in 1910 and by you later in Oudenodon) make it easier to see how such a wonderful device as the middle ear could arise without any predetermination or human-like planning, and in fact in the good old Darwinian way, if only we admit that as the “twig is bent the tree’s inclined” and that each stage conserves the advantages of its predecessors… The simple idea that planning is only experience read backward and combined by selection in suitable or successful combinations takes the mystery out of Nature and out of men’s minds.

“Progress” was synonymous with distance from nature. The adults, who set the pace of progress from nature, were so absorbed by their own ability to invent and to alter the existing world, that they hurried headlong, with no design for the ultimate structure. A man-made environment was the obvious goal, but who was the responsible architect? No one in my country. Not even the king of Great Britain or the president of America. Each inventor and producer who worked on building tomorrow’s world just threw in a brick or a cogwheel wherever he cared to, and it was up to us of the next generation to find out what the result would be.

[A]s you know, scientific education is fabulously neglected … This is an evil that is inherited, passed on from generation to generation. The majority of educated persons are not interested in science, and are not aware that scientific knowledge forms part of the idealistic background of human life. Many believe—in their complete ignorance of what science really is—that it has mainly the ancillary task of inventing new machinery, or helping to invent it, for improving our conditions of life. They are prepared to leave this task to the specialists, as they leave the repairing of their pipes to the plumber. If persons with this outlook decide upon the curriculum of our children, the result is necessarily such as I have just described it.

[American] Motherhood is like being a crack tennis player or ballet dancer—it lasts just so long, then it’s over. We’ve made an abortive effort to turn women into people. We’ve sent them to school and put them in slacks. But we’ve focused on wifehood and reproductivity with no clue about what to do with mother after the children have left home. We’ve found no way of using the resources of women in the 25 years of post-menopausal zest. As a result many women seem to feel they should live on the recognition and care of society.

[D]iscovery should come as an adventure rather than as the result of a logical process of thought. Sharp, prolonged thinking is necessary that we may keep on the chosen road but it does not itself necessarily lead to discovery. The investigator must be ready and on the spot when the light comes from whatever direction.

[In the case of research director, Willis R. Whitney, whose style was to give talented investigators as much freedom as possible, you may define “serendipity” as] the art of profiting from unexpected occurrences. When you do things in that way you get unexpected results. Then you do something else and you get unexpected results in another line, and you do that on a third line and then all of a sudden you see that one of these lines has something to do with the other. Then you make a discovery that you never could have made by going on a direct road.

[It] may be laid down as a general rule that, if the result of a long series of precise observations approximates a simple relation so closely that the remaining difference is undetectable by observation and may be attributed to the errors to which they are liable, then this relation is probably that of nature.

[Louis Rendu, Bishop of Annecy] collects observations, makes experiments, and tries to obtain numerical results; always taking care, however, so to state his premises and qualify his conclusions that nobody shall be led to ascribe to his numbers a greater accuracy than they merit. It is impossible to read his work, and not feel that he was a man of essentially truthful mind and that science missed an ornament when he was appropriated by the Church.

[Modern science] passed through a long period of uncertainty and inconclusive experiment, but as the instrumental aids to research improved, and the results of observation accumulated, phantoms of the imagination were exorcised, idols of the cave were shattered, trustworthy materials were obtained for logical treatment, and hypotheses by long and careful trial were converted into theories.

[Professor W.L. Bragg asserts that] In sodium chloride there appear to be no molecules represented by NaCl. The equality in number of sodium and chlorine atoms is arrived at by a chess-board pattern of these atoms; it is a result of geometry and not of a pairing-off of the atoms.

[The ancient monuments] were all dwarfs in size and pigmies in spirit beside this mighty Statue of Liberty, and its inspiring thought. Higher than the monument in Trafalgar Square which commemorates the victories of Nelson on the sea; higher than the Column Vendome, which perpetuates the triumphs of Napoleon on the land; higher than the towers of the Brooklyn Bridge, which exhibit the latest and greatest results of science, invention, and industrial progress, this structure rises toward the heavens to illustrate an idea ... which inspired the charter in the cabin of the Mayflower and the Declaration of Independence from the Continental Congress.

[The unreactivity of the noble gas elements] belongs to the surest of experimental results.

[There is no shortage of scientific talent.] But [I am] much less optimistic about the managerial vision [of the pharmaceutical industry] to catalyse these talents to deliver the results we all want.

[There] are cases where there is no dishonesty involved but where people are tricked into false results by a lack of understanding about what human beings can do to themselves in the way of being led astray by subjective effects, wishful thinking or threshold interactions. These are examples of pathological science. These are things that attracted a great deal of attention. Usually hundreds of papers have been published upon them. Sometimes they have lasted for fifteen or twenty years and then they gradually die away.
[Coining the term “pathological science” for the self-deceiving application of science to a phenomenon that doesn't exist.]

[To a man expecting a scientific proof of the impossibility of flying saucers] I might have said to him: “Listen, I mean that from my knowledge of the world that I see around me, I think that it is much more likely that the reports of flying saucers are the results of the known irrational characteristics of terrestrial intelligence than of the unknown rational efforts of extra-terrestrial intelligence.” It is just more likely, that is all. It is a good guess. And we always try to guess the most likely explanation, keeping in the back of the mind the fact that if it does not work we must discuss the other possibilities.

[About the demand of the Board of Regents of the University of California that professors sign non-Communist loyalty oaths or lose their jobs within 65 days.] No conceivable damage to the university at the hands of hypothetical Communists among us could possibly have equaled the damage resulting from the unrest, ill-will and suspicion engendered by this series of events.

[In refutation of evolution] There is not enough evidence, consistent evidence to make it as fact, and I say that because for theory to become a fact, it needs to consistently have the same results after it goes through a series of tests. The tests that they put—that they use to support evolution do not have consistent results. Now too many people are blindly accepting evolution as fact. But when you get down to the hard evidence, it’s merely a theory.
[In favor of the teaching of creationism alongside evolution in schools.]

[In refutation of evolution] They use carbon dating ... to prove that something was millions of years old. Well, we have the eruption of Mt. Saint Helens and the carbon dating test that they used then would have to then prove that these were hundreds of millions of years younger, when what happened was they had the exact same results on the fossils and canyons that they did the tests on that were supposedly 100 millions of years old. And it’s the kind of inconsistent tests like this that they’re basing their “facts” on.
[Citing results from a solitary young-Earth creationist, questioning whether the lava dome at Mount St. Helens is really a million years old.]

[When recording electrical impulses from a frog nerve-muscle preparation seemed to show a tiresomely oscillating electrical artefact—but only when the muscle was hanging unsupported.] The explanation suddenly dawned on me ... a muscle hanging under its own weight ought, if you come to think of it, to be sending sensory impulses up the nerves coming from the muscle spindles ... That particular day’s work, I think, had all the elements that one could wish for. The new apparatus seemed to be misbehaving very badly indeed, and I suddenly found it was behaving so well that it was opening up an entire new range of data ... it didn’t involve any particular hard work, or any particular intelligence on my part. It was just one of those things which sometimes happens in a laboratory if you stick apparatus together and see what results you get.

Conclusions
I. A curve has been found representing the frequency distribution of standard deviations of samples drawn from a normal population.
II. A curve has been found representing the frequency distribution of values of the means of such samples, when these values are measured from the mean of the population in terms of the standard deviation of the sample…
IV. Tables are given by which it can be judged whether a series of experiments, however short, have given a result which conforms to any required standard of accuracy or whether it is necessary to continue the investigation.

Drosophila melanogaster has been more extensively used in the study of genetics than any other organism, and the theory of heredity that is now generally accepted is based chiefly on the results obtained with this fly. … Not only has Drosophila been the most productive material for research in the subject, but it is now the standard object for laboratory instruction, and is used as such in many colleges and universities.

Man is the result of slow growth; that is why he occupies the position he does in animal life. What does a pup amount to that has gained its growth in a few days or weeks, beside a man who only attains it in as many years.

~~[Attributed without source]~~ If your result needs a statistician then you should design a better experiment.

~~[Attributed]~~ I have had my results for a long time; but I do not yet know how I am to arrive at them.

A … difference between most system-building in the social sciences and systems of thought and classification of the natural sciences is to be seen in their evolution. In the natural sciences both theories and descriptive systems grow by adaptation to the increasing knowledge and experience of the scientists. In the social sciences, systems often issue fully formed from the mind of one man. Then they may be much discussed if they attract attention, but progressive adaptive modification as a result of the concerted efforts of great numbers of men is rare.

A general course in mathematics should be required of all officers for its practical value, but no less for its educational value in training the mind to logical forms of thought, in developing the sense of absolute truthfulness, together with a confidence in the accomplishment of definite results by definite means.

A casual glance at crystals may lead to the idea that they were pure sports of nature, but this is simply an elegant way of declaring one’s ignorance. With a thoughtful examination of them, we discover laws of arrangement. With the help of these, calculation portrays and links up the observed results. How variable and at the same time how precise and regular are these laws! How simple they are ordinarily, without losing anything of their significance! The theory which has served to develop these laws is based entirely on a fact, whose existence has hitherto been vaguely discerned rather than demonstrated. This fact is that in all minerals which belong to the same species, these little solids, which are the crystal elements and which I call their integrant molecules, have an invariable form, in which the faces lie in the direction of the natural fracture surfaces corresponding to the mechanical division of the crystals. Their angles and dimensions are derived from calculations combined with observation.

A closer look at the course followed by developing theory reveals for a start that it is by no means as continuous as one might expect, but full of breaks and at least apparently not along the shortest logical path. Certain methods often afforded the most handsome results only the other day, and many might well have thought that the development of science to infinity would consist in no more than their constant application. Instead, on the contrary, they suddenly reveal themselves as exhausted and the attempt is made to find other quite disparate methods. In that event there may develop a struggle between the followers of the old methods and those of the newer ones. The former's point of view will be termed by their opponents as out-dated and outworn, while its holders in turn belittle the innovators as corrupters of true classical science.

A few of the results of my activities as a scientist have become embedded in the very texture of the science I tried to serve—this is the immortality that every scientist hopes for. I have enjoyed the privilege, as a university teacher, of being in a position to influence the thought of many hundreds of young people and in them and in their lives I shall continue to live vicariously for a while. All the things I care for will continue for they will be served by those who come after me. I find great pleasure in the thought that those who stand on my shoulders will see much farther than I did in my time. What more could any man want?

A moment’s consideration of this case shows what a really great advance in the theory and practise of breeding has been obtained through the discovery of Mendel’s law. What a puzzle this case would have presented to the biologist ten years ago! Agouti crossed with chocolate gives in the second filial generation (not in the first) four varieties, viz., agouti, chocolate, black and cinnamon. We could only have shaken our heads and looked wise (or skeptical).
Then we had no explanation to offer for such occurrences other than the “instability of color characters under domestication,” the “effects of inbreeding,” “maternal impressions.” Serious consideration would have been given to the proximity of cages containing both black and cinnamon-agouti mice.
Now we have a simple, rational explanation, which anyone can put to the test. We are able to predict the production of new varieties, and to produce them.
We must not, of course, in our exuberance, conclude that the powers of the hybridizer know no limits. The result under consideration consists, after all, only in the making of new combinations of unit characters, but it is much to know that these units exist and that all conceivable combinations of them are ordinarily capable of production. This valuable knowledge we owe to the discoverer and to the rediscoverers of Mendel’s law.

A philosopher once said, “It is necessary for the very existence of science that the same conditions always produce the same results”. Well, they do not.

A pound of energy with an ounce of talent will achieve greater results than a pound of talent with an ounce of energy.

A professor … may be to produce a perfect mathematical work of art, having every axiom stated, every conclusion drawn with flawless logic, the whole syllabus covered. This sounds excellent, but in practice the result is often that the class does not have the faintest idea of what is going on. … The framework is lacking; students do not know where the subject fits in, and this has a paralyzing effect on the mind.

A rose is the visible result of an infinitude of complicated goings on in the bosom of the earth and in the air above, and similarly a work of art is the product of strange activities in the human mind.

A scientific invention consists of six (or some number) ideas, five of which are absurd but which, with the addition of the sixth and enough rearrangement of the combinations, results in something no one has thought of before.

A student who wishes now-a-days to study geometry by dividing it sharply from analysis, without taking account of the progress which the latter has made and is making, that student no matter how great his genius, will never be a whole geometer. He will not possess those powerful instruments of research which modern analysis puts into the hands of modern geometry. He will remain ignorant of many geometrical results which are to be found, perhaps implicitly, in the writings of the analyst. And not only will he be unable to use them in his own researches, but he will probably toil to discover them himself, and, as happens very often, he will publish them as new, when really he has only rediscovered them.

A superficial knowledge of mathematics may lead to the belief that this subject can be taught incidentally, and that exercises akin to counting the petals of flowers or the legs of a grasshopper are mathematical. Such work ignores the fundamental idea out of which quantitative reasoning grows—the equality of magnitudes. It leaves the pupil unaware of that relativity which is the essence of mathematical science. Numerical statements are frequently required in the study of natural history, but to repeat these as a drill upon numbers will scarcely lend charm to these studies, and certainly will not result in mathematical knowledge.

A superficial knowledge of mathematics may lead to the belief that this subject can be taught incidentally, and that exercises akin to counting the petals of flowers or the legs of a grasshopper are mathematical. Such work ignores the fundamental idea out of which quantitative reasoning grows—the equality of magnitudes. It leaves the pupil unaware of that relativity which is the essence of mathematical science. Numerical statements are frequently required in the study of natural history, but to repeat these as a drill upon numbers will scarcely lend charm to these studies, and certainly will not result in mathematical knowledge.

A surplus of ideas is as dangerous as a drought. The tendency to jump from idea to idea spreads your energy horizontally rather than vertically. As a result you'll struggle to make progress.

A vital phenomenon can only be regarded as explained if it has been proven that it appears as the result of the material components of living organisms interacting according to the laws which those same components follow in their interactions outside of living systems.

Abraham Maslow, felt … [an] instinctive revolt against the “atmosphere” of Freudian psychology, with its emphasis on sickness and neurosis, and decided that he might obtain some equally interesting results if he studied extremely healthy people.

Accurate and minute measurement seems to the non-scientific imagination, a less lofty and dignified work than looking for something new. But nearly all the grandest discoveries of science have been but the rewards of accurate measurement and patient long-continued labour in the minute sifting of numerical results.

Act as if you are going to live for ever and cast your plans way ahead. You must feel responsible without time limitations, and the consideration of whether you may or may not be around to see the results should never enter your thoughts.

After an orange cloud—formed as a result of a dust storm over the Sahara and caught up by air currents—reached the Philippines and settled there with rain, I understood that we are all sailing in the same boat.

After the discovery of spectral analysis no one trained in physics could doubt the problem of the atom would be solved when physicists had learned to understand the language of spectra. So manifold was the enormous amount of material that has been accumulated in sixty years of spectroscopic research that it seemed at first beyond the possibility of disentanglement. An almost greater enlightenment has resulted from the seven years of Röntgen spectroscopy, inasmuch as it has attacked the problem of the atom at its very root, and illuminates the interior. What we are nowadays hearing of the language of spectra is a true 'music of the spheres' in order and harmony that becomes ever more perfect in spite of the manifold variety. The theory of spectral lines will bear the name of Bohr for all time. But yet another name will be permanently associated with it, that of Planck. All integral laws of spectral lines and of atomic theory spring originally from the quantum theory. It is the mysterious organon on which Nature plays her music of the spectra, and according to the rhythm of which she regulates the structure of the atoms and nuclei.

Again and again in reading even his [William Thomson] most abstract writings one is struck by the tenacity with which physical ideas control in him the mathematical form in which he expressed them. An instance of this is afforded by … an example of a mathematical result that is, in his own words, “not instantly obvious from the analytical form of my solution, but which we immediately see must be the case by thinking of the physical meaning of the result.”

All living forms are the results of physical influences which are still in operation, and vary only in degree and direction

All palaetiological sciences, all speculations which attempt to ascend from the present to the remote past, by the chain of causation, do also, by an inevitable consequence, urge us to look for the beginning of the state of things which we thus contemplate; but in none of these cases have men been able, by the aid of science, to arrive at a beginning which is homogeneous with the known course of events. The first origin of language, of civilization, of law and government, cannot be clearly made out by reasoning and research; and just as little, we may expect, will a knowledge of the origin of the existing and extinct species of plants and animals, be the result of physiological and geological investigation.

All that we can hope from these inspirations, which are the fruits of unconscious work, is to obtain points of departure for such calculations. As for the calculations themselves, they must be made in the second period of conscious work which follows the inspiration, and in which the results of the inspiration are verified and the consequences deduced.

All the events which occur upon the earth result from Law: even those actions which are entirely dependent on the caprices of the memory, or the impulse of the passions, are shown by statistics to be, when taken in the gross, entirely independent of the human will. As a single atom, man is an enigma; as a whole, he is a mathematical problem. As an individual, he is a free agent; as a species, the offspring of necessity.

All the human culture, all the results of art, science and technology that we see before us today, are almost exclusively the creative product of the Aryan. This very fact admits of the not unfounded inference that he alone was the founder of all higher humanity, therefore representing the prototype of all that we understand by the word 'man.' He is the Prometheus of mankind from whose shining brow the divine spark of genius has sprung at all times, forever kindling anew that fire of knowledge which illuminated the night of silent mysteries and thus caused man to climb the path to mastery over the other beings of the earth ... It was he who laid the foundations and erected the walls of every great structure in human culture.

All things on the earth are the result of chemical combination. The operation by which the commingling of molecules and the interchange of atoms take place we can imitate in our laboratories; but in nature they proceed by slow degrees, and, in general, in our hands they are distinguished by suddenness of action. In nature chemical power is distributed over a long period of time, and the process of change is scarcely to be observed. By acts we concentrate chemical force, and expend it in producing a change which occupies but a few hours at most.

Almost all the greatest discoveries in astronomy have resulted from what we have elsewhere termed Residual Phenomena, of a qualitative or numerical kind, of such portions of the numerical or quantitative results of observation as remain outstanding and unaccounted for, after subducting and allowing for all that would result from the strict application of known principles.

Although I must say that research problems I worked on were frequently the result of serendipity and often grew out of my interest in some species or some environment which I found to be particularly appealing—marine birds and tropical islands for example.

Among the minor, yet striking characteristics of mathematics, may be mentioned the fleshless and skeletal build of its propositions; the peculiar difficulty, complication, and stress of its reasonings; the perfect exactitude of its results; their broad universality; their practical infallibility.

An experiment is never a failure solely because it fails to achieve predicted results. An experiment is a failure only when it also fails adequately to test the hypothesis in question, when the data it produces don’t prove anything one way or another.

An induction shock results in a contraction or fails to do so according to its strength; if it does so at all, it produces in the muscle at that time the maximal contraction that can result from stimuli of any strength.

Anaximenes ... said that infinite air was the principle, from which the things that are becoming, and that are, and that shall be, and gods and things divine, all come into being, and the rest from its products. The form of air is of this kind: whenever it is most equable it is invisible to sight, but is revealed by the cold and the hot and the damp and by movement. It is always in motion; for things that change do not change unless there be movement. Through becoming denser or finer it has different appearances; for when it is dissolved into what is finer it becomes fire, while winds, again, are air that is becoming condensed, and cloud is produced from air by felting. When it is condensed still more, water is produced; with a further degree of condensation earth is produced, and when condensed as far as possible, stones. The result is that the most influential components of the generation are opposites, hot and cold.

Any chemist reading this book can see, in some detail, how I have spent most of my mature life. They can become familiar with the quality of my mind and imagination. They can make judgements about my research abilities. They can tell how well I have documented my claims of experimental results. Any scientist can redo my experiments to see if they still work—and this has happened! I know of no other field in which contributions to world culture are so clearly on exhibit, so cumulative, and so subject to verification.

Anyone who understands algebraic notation, reads at a glance in an equation results reached arithmetically only with great labour and pains.

As a man who has devoted his whole life to the most clear headed science, to the study of matter, I can tell you as a result of my research about atoms this much: There is no matter as such. All matter originates and exists only by virtue of a force which brings the particle of an atom to vibration and holds this most minute solar system of the atom together. … We must assume behind this force the existence of a conscious and intelligent mind. This mind is the matrix of all matter.

As a result of the phenomenally rapid change and growth of physics, the men and women who did their great work one or two generations ago may be our distant predecessors in terms of the state of the field, but they are our close neighbors in terms of time and tastes. This may be an unprecedented state of affairs among professionals; one can perhaps be forgiven if one characterizes it epigrammatically with a disastrously mixed metaphor; in the sciences, we are now uniquely privileged to sit side-by-side with the giants on whose shoulders we stand.

As an adult she had her organs removed one by one. Now she is a mere shell with symptoms where her organs used to be.
Written as an intern on one of his patient's charts; commentary on the result of surgical treatment of non-organic disease.

As modern physics started with the Newtonian revolution, so modern philosophy starts with what one might call the Cartesian Catastrophe. The catastrophe consisted in the splitting up of the world into the realms of matter and mind, and the identification of “mind” with conscious thinking. The result of this identification was the shallow rationalism of l’esprit Cartesien, and an impoverishment of psychology which it took three centuries to remedy even in part.

As pure truth is the polar star of our science [mathematics], so it is the great advantage of our science over others that it awakens more easily the love of truth in our pupils. … If Hegel justly said, “Whoever does not know the works of the ancients, has lived without knowing beauty,” Schellbach responds with equal right, “Who does not know mathematics, and the results of recent scientific investigation, dies without knowing truth.”

As science is more and more subject to grave misuse as well as to use for human benefit it has also become the scientist's responsibility to become aware of the social relations and applications of his subject, and to exert his influence in such a direction as will result in the best applications of the findings in his own and related fields. Thus he must help in educating the public, in the broad sense, and this means first educating himself, not only in science but in regard to the great issues confronting mankind today.

As soon as we got rid of the backroom attitude and brought our apparatus fully into the Department with an inexhaustible supply of living patients with fascinating clinical problems, we were able to get ahead really fast. Any new technique becomes more attractive if its clinical usefulness can be demonstrated without harm, indignity or discomfort to the patient... Anyone who is satisfied with his diagnostic ability and with his surgical results is unlikely to contribute much to the launching of a new medical science. He should first be consumed with a divine discontent with things as they are. It greatly helps, of course, to have the right idea at the right time, and quite good ideas may come, Archimedes fashion, in one's bath..

Asian Homo erectus died without issue and does not enter our immediate ancestry (for we evolved from African populations); Neanderthal people were collateral cousins, perhaps already living in Europe while we emerged in Africa... In other words, we are an improbable and fragile entity, fortunately successful after precarious beginnings as a small population in Africa, not the predictable end result of a global tendency. We are a thing, an item of history, not an embodiment of general principles.

Astronomy was not studied by Kepler, Galileo, or Newton for the practical applications which might result from it, but to enlarge the bounds of knowledge, to furnish new objects of thought and contemplation in regard to the universe of which we form a part; yet how remarkable the influence which this science, apparently so far removed from the sphere of our material interests, has exerted on the destinies of the world!

At last such field studies have been put on a sound basis which should result in the hunting of information rather than specimens.

At no period of [Michael Faraday’s] unmatched career was he interested in utility. He was absorbed in disentangling the riddles of the universe, at first chemical riddles, in later periods, physical riddles. As far as he cared, the question of utility was never raised. Any suspicion of utility would have restricted his restless curiosity. In the end, utility resulted, but it was never a criterion to which his ceaseless experimentation could be subjected.

Bad science contributes to the steady dumbing down of our nation. Crude beliefs get transmitted to political leaders and the result is considerable damage to society. We see this happening now in the rapid rise of the religious right and how it has taken over large segments of the Republican Party.

Basic research may seem very expensive. I am a well-paid scientist. My hourly wage is equal to that of a plumber, but sometimes my research remains barren of results for weeks, months or years and my conscience begins to bother me for wasting the taxpayer’s money. But in reviewing my life’s work, I have to think that the expense was not wasted.
Basic research, to which we owe everything, is relatively very cheap when compared with other outlays of modern society. The other day I made a rough calculation which led me to the conclusion that if one were to add up all the money ever spent by man on basic research, one would find it to be just about equal to the money spent by the Pentagon this past year.

Before an experiment can be performed, it must be planned—the question to nature must be formulated before being posed. Before the result of a measurement can be used, it must be interpreted—nature's answer must be understood properly. These two tasks are those of the theorist, who finds himself always more and more dependent on the tools of abstract mathematics. Of course, this does not mean that the experimenter does not also engage in theoretical deliberations. The foremost classical example of a major achievement produced by such a division of labor is the creation of spectrum analysis by the joint efforts of Robert Bunsen, the experimenter, and Gustav Kirchoff, the theorist. Since then, spectrum analysis has been continually developing and bearing ever richer fruit.

Before the introduction of the Arabic notation, multiplication was difficult, and the division even of integers called into play the highest mathematical faculties. Probably nothing in the modern world could have more astonished a Greek mathematician than to learn that, under the influence of compulsory education, the whole population of Western Europe, from the highest to the lowest, could perform the operation of division for the largest numbers. This fact would have seemed to him a sheer impossibility. … Our modern power of easy reckoning with decimal fractions is the most miraculous result of a perfect notation.

Besides accustoming the student to demand, complete proof, and to know when he has not obtained it, mathematical studies are of immense benefit to his education by habituating him to precision. It is one of the peculiar excellencies of mathematical discipline, that the mathematician is never satisfied with à peu près. He requires the exact truth. Hardly any of the non-mathematical sciences, except chemistry, has this advantage. One of the commonest modes of loose thought, and sources of error both in opinion and in practice, is to overlook the importance of quantities. Mathematicians and chemists are taught by the whole course of their studies, that the most fundamental difference of quality depends on some very slight difference in proportional quantity; and that from the qualities of the influencing elements, without careful attention to their quantities, false expectation would constantly be formed as to the very nature and essential character of the result produced.

Blood mixture and the result drop in the racial level is the sole cause of the dying out of old cultures; for men do not perish as a result of lost wars, but by the loss of that force of resistance which is continued only in pure blood. All who are not of good race in this world are chaff.

Borel makes the amusing supposition of a million monkeys allowed to play upon the keys of a million typewriters. What is the chance that this wanton activity should reproduce exactly all of the volumes which are contained in the library of the British Museum? It certainly is not a large chance, but it may be roughly calculated, and proves in fact to be considerably larger than the chance that a mixture of oxygen and nitrogen will separate into the two pure constituents. After we have learned to estimate such minute chances, and after we have overcome our fear of numbers which are very much larger or very much smaller than those ordinarily employed, we might proceed to calculate the chance of still more extraordinary occurrences, and even have the boldness to regard the living cell as a result of random arrangement and rearrangement of its atoms. However, we cannot but feel that this would be carrying extrapolation too far. This feeling is due not merely to a recognition of the enormous complexity of living tissue but to the conviction that the whole trend of life, the whole process of building up more and more diverse and complex structures, which we call evolution, is the very opposite of that which we might expect from the laws of chance.

But as no two (theoreticians) agree on this (skin friction) or any other subject, some not agreeing today with what they wrote a year ago, I think we might put down all their results, add them together, and then divide by the number of mathematicians, and thus find the average coefficient of error. (1908)

But from the time I was in college I learned that there is nothing one could imagine which is so strange and incredible that it was not said by some philosopher; and since that time, I have recognized through my travels that all those whose views are different from our own are not necessarily, for that reason, barbarians or savages, but that many of them use their reason either as much as or even more than we do. I also considered how the same person, with the same mind, who was brought up from infancy either among the French or the Germans, becomes different from what they would have been if they had always lived among the Chinese or among the cannibals, and how, even in our clothes fashions, the very thing that we liked ten years ago, and that we may like again within the next ten years, appears extravagant and ridiculous to us today. Thus our convictions result from custom and example very much more than from any knowledge that is certain... truths will be discovered by an individual rather than a whole people.

But it is precisely mathematics, and the pure science generally, from which the general educated public and independent students have been debarred, and into which they have only rarely attained more than a very meagre insight. The reason of this is twofold. In the first place, the ascendant and consecutive character of mathematical knowledge renders its results absolutely insusceptible of presentation to persons who are unacquainted with what has gone before, and so necessitates on the part of its devotees a thorough and patient exploration of the field from the very beginning, as distinguished from those sciences which may, so to speak, be begun at the end, and which are consequently cultivated with the greatest zeal. The second reason is that, partly through the exigencies of academic instruction, but mainly through the martinet traditions of antiquity and the influence of mediaeval logic-mongers, the great bulk of the elementary text-books of mathematics have unconsciously assumed a very repellant form,—something similar to what is termed in the theory of protective mimicry in biology “the terrifying form.” And it is mainly to this formidableness and touch-me-not character of exterior, concealing withal a harmless body, that the undue neglect of typical mathematical studies is to be attributed.

But science and technology are only one of the avenues toward reality; others are equally needed to comprehend the full significance of our existence. Indeed, these other avenues are necessary for the prevention of thoughtless and inhuman abuses of the results of science.

By destroying the biological character of phenomena, the use of averages in physiology and medicine usually gives only apparent accuracy to the results. From our point of view, we may distinguish between several kinds of averages: physical averages, chemical averages and physiological and pathological averages. If, for instance, we observe the number of pulsations and the degree of blood pressure by means of the oscillations of a manometer throughout one day, and if we take the average of all our figures to get the true or average blood pressure and to learn the true or average number of pulsations, we shall simply have wrong numbers. In fact, the pulse decreases in number and intensity when we are fasting and increases during digestion or under different influences of movement and rest; all the biological characteristics of the phenomenon disappear in the average. Chemical averages are also often used. If we collect a man's urine during twenty-four hours and mix all this urine to analyze the average, we get an analysis of a urine which simply does not exist; for urine, when fasting, is different from urine during digestion. A startling instance of this kind was invented by a physiologist who took urine from a railroad station urinal where people of all nations passed, and who believed he could thus present an analysis of average European urine! Aside from physical and chemical, there are physiological averages, or what we might call average descriptions of phenomena, which are even more false. Let me assume that a physician collects a great many individual observations of a disease and that he makes an average description of symptoms observed in the individual cases; he will thus have a description that will never be matched in nature. So in physiology, we must never make average descriptions of experiments, because the true relations of phenomena disappear in the average; when dealing with complex and variable experiments, we must study their various circumstances, and then present our most perfect experiment as a type, which, however, still stands for true facts. In the cases just considered, averages must therefore be rejected, because they confuse, while aiming to unify, and distort while aiming to simplify. Averages are applicable only to reducing very slightly varying numerical data about clearly defined and absolutely simple cases.

By research in pure science I mean research made without any idea of application to industrial matters but solely with the view of extending our knowledge of the Laws of Nature. I will give just one example of the ‘utility’ of this kind of research, one that has been brought into great prominence by the War—I mean the use of X-rays in surgery. Now, not to speak of what is beyond money value, the saving of pain, or, it may be, the life of the wounded, and of bitter grief to those who loved them, the benefit which the state has derived from the restoration of so many to life and limb, able to render services which would otherwise have been lost, is almost incalculable. Now, how was this method discovered? It was not the result of a research in applied science starting to find an improved method of locating bullet wounds. This might have led to improved probes, but we cannot imagine it leading to the discovery of X-rays. No, this method is due to an investigation in pure science, made with the object of discovering what is the nature of Electricity. The experiments which led to this discovery seemed to be as remote from ‘humanistic interest’ —to use a much misappropriated word—as anything that could well be imagined. The apparatus consisted of glass vessels from which the last drops of air had been sucked, and which emitted a weird greenish light when stimulated by formidable looking instruments called induction coils. Near by, perhaps, were great coils of wire and iron built up into electro-magnets. I know well the impression it made on the average spectator, for I have been occupied in experiments of this kind nearly all my life, notwithstanding the advice, given in perfect good faith, by non-scientific visitors to the laboratory, to put that aside and spend my time on something useful.

Cavendish gave me once some bits of platinum for my experiments, and came to see my results on the decomposition of the alkalis, and seemed to take an interest in them; but he encouraged no intimacy with any one, and received nobody at his own house. … He was acute, sagacious, and profound, and, I think, the most accomplished British philosopher of his time.

Cayley was singularly learned in the work of other men, and catholic in his range of knowledge. Yet he did not read a memoir completely through: his custom was to read only so much as would enable him to grasp the meaning of the symbols and understand its scope. The main result would then become to him a subject of investigation: he would establish it (or test it) by algebraic analysis and, not infrequently, develop it so to obtain other results. This faculty of grasping and testing rapidly the work of others, together with his great knowledge, made him an invaluable referee; his services in this capacity were used through a long series of years by a number of societies to which he was almost in the position of standing mathematical advisor.

Characteristically skeptical of the idea that living things would faithfully follow mathematical formulas, [Robert Harper] seized upon factors in corn which seemed to blend in the hybrid—rather than be represented by plus or minus signs, and put several seasons into throwing doubt upon the concept of immutable hypothetical units of inheritance concocted to account for selected results.

Charles Babbage proposed to make an automaton chess-player which should register mechanically the number of games lost and gained in consequence of every sort of move. Thus, the longer the automaton went on playing game, the more experienced it would become by the accumulation of experimental results. Such a machine precisely represents the acquirement of experience by our nervous organization.

Chemistry affords two general methods of determining the constituent principles of bodies, the method of analysis, and that of synthesis. When, for instance, by combining water with alkohol, we form the species of liquor called, in commercial language, brandy or spirit of wine, we certainly have a right to conclude, that brandy, or spirit of wine, is composed of alkohol combined with water. We can produce the same result by the analytical method; and in general it ought to be considered as a principle in chemical science, never to rest satisfied without both these species of proofs. We have this advantage in the analysis of atmospherical air, being able both to decompound it, and to form it a new in the most satisfactory manner.

Chemistry is yet, indeed, a mere embryon. Its principles are contested; experiments seem contradictory; their subjects are so minute as to escape our senses; and their result too fallacious to satisfy the mind. It is probably an age too soon to propose the establishment of a system.

Chemistry works with an enormous number of substances, but cares only for some few of their properties; it is an extensive science. Physics on the other hand works with rather few substances, such as mercury, water, alcohol, glass, air, but analyses the experimental results very thoroughly; it is an intensive science. Physical chemistry is the child of these two sciences; it has inherited the extensive character from chemistry. Upon this depends its all-embracing feature, which has attracted so great admiration. But on the other hand it has its profound quantitative character from the science of physics.

Collective unity is not the result of the brotherly love of the faithful for each other. The loyalty of the true believer is to the whole—the church, party, nation—and not to his fellow true believer. True loyalty between individuals is possible only in a loose and relatively free society.

Common sense … has the very curious property of being more correct retrospectively than prospectively. It seems to me that one of the principal criteria to be applied to successful science is that its results are almost always obvious retrospectively; unfortunately, they seldom are prospectively. Common sense provides a kind of ultimate validation after science has completed its work; it seldom anticipates what science is going to discover.

Common sense is in spite of, not as the result of, education.

Common sense is only the application of theories which have grown and been formulated unconsciously as result of experience.

Computers and rocket ships are examples of invention, not of understanding. … All that is needed to build machines is the knowledge that when one thing happens, another thing happens as a result. It’s an accumulation of simple patterns. A dog can learn patterns. There is no “why” in those examples. We don’t understand why electricity travels. We don’t know why light travels at a constant speed forever. All we can do is observe and record patterns.

Consider the very roots of our ability to discern truth. Above all (or perhaps I should say “underneath all”), common sense is what we depend on—that crazily elusive, ubiquitous faculty we all have to some degree or other. … If we apply common sense to itself over and over again, we wind up building a skyscraper. The ground floor of the structure is the ordinary common sense we all have, and the rules for building news floors are implicit in the ground floor itself. However, working it all out is a gigantic task, and the result is a structure that transcends mere common sense.

Descriptive geometry has two objects: the first is to establish methods to represent on drawing paper which has only two dimensions,—namely, length and width,—all solids of nature which have three dimensions,—length, width, and depth,—provided, however, that these solids are capable of rigorous definition.
The second object is to furnish means to recognize accordingly an exact description of the forms of solids and to derive thereby all truths which result from their forms and their respective positions.

Dreaming over a subject is simply … allowing the will to focus the mind passively on the subject so that it follows the trains of thought as they arise, stopping them only when unprofitable but in general allowing them to form and branch naturally until some useful and interesting results occur.

During the eighteenth and nineteenth centuries we can see the emergence of a tension that has yet to be resolved, concerning the attitude of scientists towards the usefulness of science. During this time, scientists were careful not to stress too much their relationships with industry or the military. They were seeking autonomy for their activities. On the other hand, to get social support there had to be some perception that the fruits of scientific activity could have useful results. One resolution of this dilemma was to assert that science only contributed at the discovery stage; others, industrialists for example, could apply the results. ... Few noted the ... obvious paradox of this position; that, if scientists were to be distanced from the 'evil' effects of the applications of scientific ideas, so too should they receive no credit for the 'good' or socially beneficial, effects of their activities.
Co-author with Philip Gummett (1947- ), -British social scientist

Each part of the project had a specific task. These tasks were carefully allocated and supervised so that the sum of their parts would result in the accomplishment of our over-all mission.

Edison was by far the most successful and, probably, the last exponent of the purely empirical method of investigation. Everything he achieved was the result of persistent trials and experiments often performed at random but always attesting extraordinary vigor and resource. Starting from a few known elements, he would make their combinations and permutations, tabulate them and run through the whole list, completing test after test with incredible rapidity until he obtained a clue. His mind was dominated by one idea, to leave no stone unturned, to exhaust every possibility.

England was nothing, compared to continental nations until she had become commercial … until about the middle of the last century, when a number of ingenious and inventive men, without apparent relation to each other, arose in various parts of the kingdom, succeeded in giving an immense impulse to all the branches of the national industry; the result of which has been a harvest of wealth and prosperity, perhaps without a parallel in the history of the world.

Erasmus Darwin held that every so often you should try a damn-fool experiment. He played the trombone to his tulips. This particular result was, in fact, negative.

Every good thought you think is contributing its share to the ultimate result of your life.

Every improvement that is put upon the real estate is the result of an idea in somebody's head. The skyscraper is another idea; the railroad is another; the telephone and all those things are merely symbols which represent ideas. An andiron, a wash-tub, is the result of an idea that did not exist before.

Every well established truth is an addition to the sum of human power, and though it may not find an immediate application to the economy of every day life, we may safely commit it to the stream of time, in the confident anticipation that the world will not fail to realize its beneficial results.

Everything material which is the subject of knowledge has number, order, or position; and these are her first outlines for a sketch of the universe. If our feeble hands cannot follow out the details, still her part has been drawn with an unerring pen, and her work cannot be gainsaid. So wide is the range of mathematical sciences, so indefinitely may it extend beyond our actual powers of manipulation that at some moments we are inclined to fall down with even more than reverence before her majestic presence. But so strictly limited are her promises and powers, about so much that we might wish to know does she offer no information whatever, that at other moments we are fain to call her results but a vain thing, and to reject them as a stone where we had asked for bread. If one aspect of the subject encourages our hopes, so does the other tend to chasten our desires, and he is perhaps the wisest, and in the long run the happiest, among his fellows, who has learned not only this science, but also the larger lesson which it directly teaches, namely, to temper our aspirations to that which is possible, to moderate our desires to that which is attainable, to restrict our hopes to that of which accomplishment, if not immediately practicable, is at least distinctly within the range of conception.