(1) A robot may not injure a human being, or, through inaction, allow a human being to come to harm.
(2) A robot must obey the orders given it by human beings except where such orders would conflict with the first law.
(3) A robot must protect its own existence as long as such protection does not conflict with the First or Second Law.

-------------- are like snowmen, fun at first, but not much future.

... we must first base such words as “between” upon clear concepts, a thing which is quite feasible but which I have not seen done.

...after my first feeling of revulsion had passed, I spent three of the most entertaining and instructive weeks of my life studying the fascinating molds which appeared one by one on the slowly disintegrating mass of horse-dung. Microscopic molds are both very beautiful and absorbingly interesting. The rapid growth of their spores, the way they live on each other, the manner in which the different forms come and go, is so amazing and varied that I believe a man could spend his life and not exhaust the forms or problems contained in one plate of manure.

...great difficulties are felt at first and these cannot be overcome except by starting from experiments .. and then be conceiving certain hypotheses ... But even so, very much hard work remains to be done and one needs not only great perspicacity but often a degree of good fortune.

1. The First Law of Ecology: Everything is connected to everything else.

1066. … At that time, throughout all England, a portent such as men had never seen before was seen in the heavens. Some declared that the star was a comet, which some call “the long-haired star”: it first appeared on the eve of the festival of Letania Maior, that is on 24 April, and shone every night for a week.

1104 … In this year the first day of Whitsuntide was on 5 June, and on the following Tuesday at noon there appeared four intersecting halos around the sun, white in color, and looking as if they had been painted. All who saw it were astonished, for they did not remember seeing anything like it before.

1106. … In the first week of Lent, on the Friday, 16 February, a strange star appeared in the evening, and for a long time afterwards was seen shining for a while each evening. The star made its appearance in the south-west, and seemed to be small and dark, but the light that shone from it was very bright, and appeared like an enormous beam of light shining north-east; and one evening it seemed as if the beam were flashing in the opposite direction towards the star. Some said that they had seen other unknown stars about this time, but we cannot speak about these without reservation, because we did not ourselves see them.

1122 … Thereafter there were many sailors on the sea and on inland water who said that they had seen a great and extensive fire near the ground in the northeast which continuously increased in width as it mounted to the sky. And the heavens opened into four parts and fought against it as if determined to put it out, and the fire stopped rising upwards. They saw that fire at the first streak of dawn, and it lasted until full daylight: this happened on 7 December.

Ode to The Amoeba
Recall from Time's abysmal chasm
That piece of primal protoplasm
The First Amoeba, strangely splendid,
From whom we're all of us descended.
That First Amoeba, weirdly clever,
Exists today and shall forever,
Because he reproduced by fission;
He split himself, and each division
And subdivision deemed it fitting
To keep on splitting, splitting, splitting;
So, whatsoe'er their billions be,
All, all amoebas still are he.
Zoologists discern his features
In every sort of breathing creatures,
Since all of every living species,
No matter how their breed increases
Or how their ranks have been recruited,
From him alone were evoluted.
King Solomon, the Queen of Sheba
And Hoover sprang from that amoeba;
Columbus, Shakespeare, Darwin, Shelley
Derived from that same bit of jelly.
So famed is he and well-connected,
His statue ought to be erected,
For you and I and William Beebe
Are undeniably amoebae!

Clarke's First Law - Corollary: When, however, the lay public rallies round an idea that is denounced by distinguished but elderly scientists and supports that idea with great fervor and emotion—the distinguished but elderly scientists are then, after all, probably right.

Clarke's First Law: When a distinguished but elderly scientist states that something is possible, he is almost certainly right. When he states that something is impossible, he is very probably wrong.

Das ist nicht Mathematik, das ist Theologie!
This is not mathematics; this is theology.
[Remark about David Hilbert's first proof of his finite basis theorem.]

Energie is the operation, efflux or activity of any being: as the light of the Sunne is the energie of the Sunne, and every phantasm of the soul is the energie of the soul.
[The first recorded definition of the term energy in English]

Haec quippe prima sapientiae clavis definitur, assidua scilicet seu frequens interrogatio … Dubitando enim ad inquisitionem venimus; inquirendo veritatem percipimus.
For this is the first key to wisdom, assiduous and frequent questioning. ... By doubting we come to inquiry; by inquiry we perceive the truth.

He who doth with the greatest exactness imaginable, weigh every individual thing that shall or hath hapned to his Patient, and may be known from the Observations of his own, or of others, and who afterwards compareth all these with one another, and puts them in an opposite view to such Things as happen in a healthy State; and lastly, from all this with the nicest and severest bridle upon his reasoning faculty riseth to the knowledge of the very first Cause of the Disease, and of the Remedies fit to remove them; He, and only He deserveth the Name of a true Physician.

If the Indians hadn’t spent the $24. In 1626 Peter Minuit, first governor of New Netherland, purchased Manhattan Island from the Indians for about $24. … Assume for simplicity a uniform rate of 7% from 1626 to the present, and suppose that the Indians had put their $24 at [compound] interest at that rate …. What would be the amount now, after 280 years? 24 x (1.07)280 = more than 4,042,000,000.
The latest tax assessment available at the time of writing gives the realty for the borough of Manhattan as $3,820,754,181. This is estimated to be 78% of the actual value, making the actual value a little more than $4,898,400,000.
The amount of the Indians’ money would therefore be more than the present assessed valuation but less than the actual valuation.

Imprimisque hominis est propria veri inquisitio atque investigatio.
The first duty of man is the seeking after and the investigation of truth.

Is mihi semper dicendus est inventor, qui primus evuIgaverit, vel saltem cum amicis communicaverit.
I should always call inventor him who first publishes, or at least communicates [the idea] to his friends.

Le premier regard de l’homme jeté sur l’univers n’y découvre que variété, diversité, multiplicité des phénomènes. Que ce regard soit illuminé par la science,—par la science qui rapproche l’homme de Dieu,—et la simplicité et l’unité brillent de toutes parts.
Man’s first glance at the universe discovers only variety, diversity, multiplicity of phenomena. Let that glance be illuminated by science—by the science which brings man closer to God,—and simplicity and unity shine on all sides.

L’art du chercheur c’est d’abord de se trouver un bon patron.
The researcher’s art is first of all to find himself a good boss.

Meine Herren, der Senat ist doch keine Badeanstalt.
The faculty is not a pool changing room.
Indignant reply to the blatent sex discrimination expressed in a colleague’s opposition when Hilbert proposed appointing Emmy Noether as the first woman professor at their university.

Parkinson's First Law: Work expands so as to fill the time available for its completion.

Primo enim paranda est Historia Naturalis et Experimentalis, suffidens et bona; quod fundamentum rei est: neque enim fingendum, aut excogitandum, sed inveniendum, quid natura faciat aut ferat.
For first of all we must prepare a Natural and Experimental History, sufficient and good; and this is the foundation of all; for we are not to imagine or suppose, but to discover, what nature does or may be made to do.

Quelquefois, par exemple, je me figure que je suis suspendu en l’air, et que j’y demeure sans mouvement, pendant que la Terre tourne sous moi en vingt-quatre heures. Je vois passer sous mes yeux tous ces visages différents, les uns blancs, les autres noirs, les autres basanés, les autres olivâtres. D’abord ce sont des chapeaux et puis des turbans, et puis des têtes chevelues, et puis des têtes rasées; tantôt des villes à clochers, tantôt des villes à longues aiguilles qui ont des croissants, tantôt des villes à tours de porcelaine, tantôt de grands pays qui n’ont que des cabanes; ici de vastes mers, là des déserts épouvantables; enfin, toute cette variété infinie qui est sur la surface de la Terre.
Sometimes, for instance, I imagine that I am suspended in the air, and remain there motionless, while the earth turns under me in four-and-twenty hours. I see pass beneath me all these different countenances, some white, others black, others tawny, others olive-colored. At first they wear hats, and then turbans, then heads with long hair, then heads shaven; sometimes towns with steeples, sometimes towns with long spires, which have crescents, sometimes towns with porcelain towers, sometimes extensive countries that have only huts; here wide seas; there frightful deserts; in short, all this infinite variety on the surface of the earth.

Question: State the relations existing between the pressure, temperature, and density of a given gas. How is it proved that when a gas expands its temperature is diminished?
Answer: Now the answer to the first part of this question is, that the square root of the pressure increases, the square root of the density decreases, and the absolute temperature remains about the same; but as to the last part of the question about a gas expanding when its temperature is diminished, I expect I am intended to say I don't believe a word of it, for a bladder in front of a fire expands, but its temperature is not at all diminished.

Ratbert (as lab rat, to scientist): Doc, we have to talk. Every day you feed me over a hundred pounds of macaroni and cheese. At first I thought you were just being a good host. But lately I’ve been thinking it could be something far more sinister.
Scientist (thinking): Macaroni and cheese causes paranoia.

Ron Hutcheson, a Knight-Ridder reporter: [Mr. President, what are your] personal views [about the theory of] intelligent design?
President George W. Bush: [Laughing. You're] doing a fine job of dragging me back to the past [days as governor of Texas]. ... Then, I said that, first of all, that decision should be made to local school districts, but I felt like both sides ought to be properly taught...”
Hutcheson: Both sides ought to be properly taught?
President: Yes ... so people can understand what the debate is about.
Hutcheson: So the answer accepts the validity of “intelligent design” as an alternative to evolution?
President: I think that part of education is to expose people to different schools of thought, and I'm not suggesting—you're asking me whether or not people ought to be exposed to different ideas, and the answer is yes.
Hutcheson: So we've got to give these groups—...
President: [interrupting] Very interesting question, Hutch. [Laughter from other reporters]

Science for the Citizen is ... also written for the large and growing number of adolescents, who realize that they will be the first victims of the new destructive powers of science misapplied.

The Devil: Reformers … will thrust you first into religion, where you will sprinkle water on babies to save their souls from me ; then it will drive you from religion into science, where you will snatch the babies from the water sprinkling and inoculate them with disease to save them from catching it accidentally.

Third Fisherman: Master, I marvel how the fishes live in the sea.
First Fisherman: Why, as men do a-land; the great ones eat up the little ones: I can compare our rich misers to nothing so fitly as to a whale; a’ plays and tumbles, driving the poor fry before him, and at last devours them all at a mouthful: such whales have I heard on o’ the land, who never leave gaping till they’ve swallowed the whole parish, church, steeple, bells, and all.

To Laplace, on receiving a copy of the Mécanique Céleste:
The first six months, which I can spare will be employed in reading it.

Ultima se tangunt. How expressive, how nicely characterizing withal is mathematics! As the musician recognizes Mozart, Beethoven, Schubert in the first chords, so the mathematician would distinguish his Cauchy, Gauss, Jacobi, Helmholtz in a few pages.

Wenn sich für ein neues Fossil kein, auf eigenthümliche Eigenschaften desselben hinweisender, Name auffinden lassen Will; als in welchem Falle ich mich bei dem gegenwärtigen zu befinden gestehe; so halte ich es für besser, eine solche Benennung auszuwählen, die an sich gar nichts sagt, und folglich auch zu keinen unrichtigen Begriffen Anlass geben kann. Diesem zufolge will ich den Namen für die gegenwärtige metallische Substanz, gleichergestalt wie bei dem Uranium geschehen, aus der Mythologie, und zwar von den Ursöhnen der Erde, den Titanen, entlehnen, und benenne also dieses neue Metallgeschlecht: Titanium.
Wherefore no name can be found for a new fossil [element] which indicates its peculiar and characteristic properties (in which position I find myself at present), I think it is best to choose such a denomination as means nothing of itself and thus can give no rise to any erroneous ideas. In consequence of this, as I did in the case of Uranium, I shall borrow the name for this metallic substance from mythology, and in particular from the Titans, the first sons of the earth. I therefore call this metallic genus TITANIUM.

[About reading Rachel Carson's Silent Spring, age 14, in the back seat of his parents' sedan. I almost threw up. I got physically ill when I learned that ospreys and peregrine falcons weren't raising chicks because of what people were spraying on bugs at their farms and lawns. This was the first time I learned that humans could impact the environment with chemicals. [That a corporation would create a product that didn't operate as advertised] was shocking in a way we weren't inured to.

[On seeing the marsupials in Australia for the first time and comparing them to placental mammals:] An unbeliever … might exclaim “Surely two distinct Creators must have been at work.”

[Recalling Professor Ira Remsen's remarks (1895) to a group of his graduate students about to go out with their degrees into the world beyond the university:]
He talked to us for an hour on what was ahead of us; cautioned us against giving up the desire to push ahead by continued study and work. He warned us against allowing our present accomplishments to be the high spot in our lives. He urged us not to wait for a brilliant idea before beginning independent research, and emphasized the fact the Lavoisier's first contribution to chemistry was the analysis of a sample of gypsum. He told us that the fields in which the great masters had worked were still fruitful; the ground had only been scratched and the gleaner could be sure of ample reward.

[When questioned on his longevity] First of all, I selected my ancestors very wisely. ... They were long-lived, healthy people. Then, as a chemist, I know how to eat, how to exercise, keep my blood circulating. ... I don't worry. I don't get angry at people. I don't worry about things I can't help. I do what I can to make the world a better place to live, but I don't complain if things aren't right. As a scientist I take the world as I find it.
[About celebrating his 77th birthday by swimming a half mile in 22 minutes] I used swim fins and webbed gloves because a man of intelligence should apply his power efficiently, not just churn the water.

A ... hypothesis may be suggested, which supposes the word 'beginning' as applied by Moses in the first of the Book of Genesis, to express an undefined period of time which was antecedent to the last great change that affected the surface of the earth, and to the creation of its present animal and vegetable inhabitants; during which period a long series of operations and revolutions may have been going on, which, as they are wholly unconnected with the history of the human race, are passed over in silence by the sacred historian, whose only concern with them was largely to state, that the matter of the universe is not eternal and self-existent but was originally created by the power of the Almighty.

A bird maintains itself in the air by imperceptible balancing, when near to the mountains or lofty ocean crags; it does this by means of the curves of the winds which as they strike against these projections, being forced to preserve their first impetus bend their straight course towards the sky with divers revolutions, at the beginning of which the birds come to a stop with their wings open, receiving underneath themselves the continual buffetings of the reflex courses of the winds.

A chemist says that the first alcohol was distilled in Arabia, which may explain those nights.

A Chinese tale tells of some men sent to harm a young girl who, upon seeing her beauty, become her protectors rather than her violators. That’s how I felt seeing the Earth for the first time. "I could not help but love and cherish her.

A few days afterwards, I went to him [the same actuary referred to in another quote] and very gravely told him that I had discovered the law of human mortality in the Carlisle Table, of which he thought very highly. I told him that the law was involved in this circumstance. Take the table of the expectation of life, choose any age, take its expectation and make the nearest integer a new age, do the same with that, and so on; begin at what age you like, you are sure to end at the place where the age past is equal, or most nearly equal, to the expectation to come. “You don’t mean that this always happens?”—“Try it.” He did try, again and again; and found it as I said. “This is, indeed, a curious thing; this is a discovery!” I might have sent him about trumpeting the law of life: but I contented myself with informing him that the same thing would happen with any table whatsoever in which the first column goes up and the second goes down.

A first step in the study of civilization is to dissect it into details, and to classify these in their proper groups. Thus, in examining weapons, they are to be classed under spear, club, sling, bow and arrow, and so forth; among textile arts are to be ranged matting, netting, and several grades of making and weaving threads; myths are divided under such headings as myths of sunrise and sunset, eclipse-myths, earthquake-myths, local myths which account for the names of places by some fanciful tale, eponymic myths which account for the parentage of a tribe by turning its name into the name of an imaginary ancestor; under rites and ceremonies occur such practices as the various kinds of sacrifice to the ghosts of the dead and to other spiritual beings, the turning to the east in worship, the purification of ceremonial or moral uncleanness by means of water or fire. Such are a few miscellaneous examples from a list of hundreds … To the ethnographer, the bow and arrow is the species, the habit of flattening children’s skulls is a species, the practice of reckoning numbers by tens is a species. The geographical distribution of these things, and their transmission from region to region, have to be studied as the naturalist studies the geography of his botanical and zoological species.

A first-rate laboratory is one in which mediocre scientists can produce outstanding work.

A good ornithologist should be able to distinguish birds by their air as well as by their colors and shape; on the ground as well as on the wing, and in the bush as well as in the hand. For, though it must not be said that every species of birds has a manner peculiar to itself, yet there is somewhat, in most genera at least, that at first sight discriminates them and enables a judicious observer to pronounce upon them with some certainty.

A great ball of fire about a mile in diameter, changing colors as it kept shooting upward, from deep purple to orange, expanding, growing bigger, rising as it was expanding, an elemental force freed from its bonds after being chained for billions of years.
On the first atomic explosion in New Mexico, 16 Jul 1945.

A man who is convinced of the truth of his religion is indeed never tolerant. At the least, he is to feel pity for the adherent of another religion but usually it does not stop there. The faithful adherent of a religion will try first of all to convince those that believe in another religion and usually he goes on to hatred if he is not successful. However, hatred then leads to persecution when the might of the majority is behind it.

A man who sets out to justify his existence and his activities has to distinguish two different questions. The first is whether the work which he does is worth doing; and the second is why he does it (whatever its value may be).

A man’s first duty, a young man’s at any rate, is to be ambitious … the noblest ambition is that of leaving behind one something of permanent value.

A man’s value to the community depends primarily on how far his feelings, thoughts, and actions are directed towards promoting the good of his fellows. We call him good or bad according to how he stands in this matter. It looks at first sight as if our estimate of a man depended entirely on his social qualities.

A mathematical theory is not to be considered complete until you have made it so clear that you can explain it to the first man whom you meet on the street.

A mathematician of the first rank, Laplace quickly revealed himself as only a mediocre administrator; from his first work we saw that we had been deceived. Laplace saw no question from its true point of view; he sought subtleties everywhere; had only doubtful ideas, and finally carried the spirit of the infinitely small into administration.

A mathematician will recognise Cauchy, Gauss, Jacobi or Helmholtz after reading a few pages, just as musicians recognise, from the first few bars, Mozart, Beethoven or Schubert.

A moment’s consideration of this case shows what a really great advance in the theory and practise of breeding has been obtained through the discovery of Mendel’s law. What a puzzle this case would have presented to the biologist ten years ago! Agouti crossed with chocolate gives in the second filial generation (not in the first) four varieties, viz., agouti, chocolate, black and cinnamon. We could only have shaken our heads and looked wise (or skeptical).
Then we had no explanation to offer for such occurrences other than the “instability of color characters under domestication,” the “effects of inbreeding,” “maternal impressions.” Serious consideration would have been given to the proximity of cages containing both black and cinnamon-agouti mice.
Now we have a simple, rational explanation, which anyone can put to the test. We are able to predict the production of new varieties, and to produce them.
We must not, of course, in our exuberance, conclude that the powers of the hybridizer know no limits. The result under consideration consists, after all, only in the making of new combinations of unit characters, but it is much to know that these units exist and that all conceivable combinations of them are ordinarily capable of production. This valuable knowledge we owe to the discoverer and to the rediscoverers of Mendel’s law.

A multitude of words doth rather obscure than illustrate, they being a burden to the memory, and the first apt to be forgotten, before we come to the last. So that he that uses many words for the explaining of any subject, doth, like the cuttle-fish, hide himself, for the most part, in his own ink.

A number of years ago, when I was a freshly-appointed instructor, I met, for the first time, a certain eminent historian of science. At the time I could only regard him with tolerant condescension.
I was sorry of the man who, it seemed to me, was forced to hover about the edges of science. He was compelled to shiver endlessly in the outskirts, getting only feeble warmth from the distant sun of science- in-progress; while I, just beginning my research, was bathed in the heady liquid heat up at the very center of the glow.
In a lifetime of being wrong at many a point, I was never more wrong. It was I, not he, who was wandering in the periphery. It was he, not I, who lived in the blaze.
I had fallen victim to the fallacy of the “growing edge;” the belief that only the very frontier of scientific advance counted; that everything that had been left behind by that advance was faded and dead.
But is that true? Because a tree in spring buds and comes greenly into leaf, are those leaves therefore the tree? If the newborn twigs and their leaves were all that existed, they would form a vague halo of green suspended in mid-air, but surely that is not the tree. The leaves, by themselves, are no more than trivial fluttering decoration. It is the trunk and limbs that give the tree its grandeur and the leaves themselves their meaning.
There is not a discovery in science, however revolutionary, however sparkling with insight, that does not arise out of what went before. “If I have seen further than other men,” said Isaac Newton, “it is because I have stood on the shoulders of giants.”

A person filled with gumption doesn’t sit about stewing about things. He’s at the front of the train of his own awareness, watching to see what’s up the track and meeting it when it comes. That’s gumption. If you’re going to repair a motorcycle, an adequate supply of gumption is the first and most important tool. If you haven’t got that you might as well gather up all the other tools and put them away, because they won’t do you any good.

A physician’s subject of study is necessarily the patient, and his first field for observation is the hospital. But if clinical observation teaches him to know the form and course of diseases, it cannot suffice to make him understand their nature; to this end he must penetrate into the body to find which of the internal parts are injured in their functions. That is why dissection of cadavers and microscopic study of diseases were soon added to clinical observation. But to-day these various methods no longer suffice; we must push investigation further and, in analyzing the elementary phenomena of organic bodies, must compare normal with abnormal states. We showed elsewhere how incapable is anatomy alone to take account of vital phenenoma, and we saw that we must add study of all physico-chemical conditions which contribute necessary elements to normal or pathological manifestations of life. This simple suggestion already makes us feel that the laboratory of a physiologist-physician must be the most complicated of all laboratories, because he has to experiment with phenomena of life which are the most complex of all natural phenomena.

A practical botanist will distinguish, at the first glance, the plant of different quarters of the globe, and yet will be at a loss to tell by what mark he detects them. There is, I know not what look—sinister, dry, obscure, in African plants; superb and elevated in the Asiatic; smooth and cheerful in the American; stunted and indurated in the Alpine.

A scientific observation is always a committed observation. It confirms or denies one’s preconceptions, one’s first ideas, one’s plan of observation. It shows by demonstration. It structures the phenomenon. It transcends what is close at hand. It reconstructs the real after having reconstructed its representation.

A sound Physics of the Earth should include all the primary considerations of the earth's atmosphere, of the characteristics and continual changes of the earth's external crust, and finally of the origin and development of living organisms. These considerations naturally divide the physics of the earth into three essential parts, the first being a theory of the atmosphere, or Meteorology, the second, a theory of the earth's external crust, or Hydrogeology, and the third, a theory of living organisms, or Biology.

A wonderful exhilaration comes from holding in the mind the deepest questions we can ask. Such questions animate all scientists. Many students of science were first attracted to the field as children by popular accounts of important unsolved problems. They have been waiting ever since to begin working on a mystery. [With co-author Arthur Zajonc]

About ten months ago [1609] a report reached my ears that a certain Fleming [Hans Lippershey] had constructed a spyglass, by means of which visible objects, though very distant from the eye of the observer, were distinctly seen as if nearby... Of this truly remarkable effect several experiences were related, to which some persons gave credence while others denied them. A few days later the report was confirmed to me in a letter from a noble Frenchman at Paris, Jacques Badovere, which caused me to apply myself wholeheartedly to enquire into the means by which I might arrive at the invention of a similar instrument. This I did shortly afterwards, my basis being the theory of refraction. First I prepared a tube of lead, at the ends of which I fitted two glass lenses, both plane on one side while on the other side one was spherically convex and the other concave.

Abroad, energy efficiency was a respectable form of engineering. Whereas Americans largely purchased by least “first cost,” Europeans understood and operated under the concept of “life cycle cost.”

According to Democritus, atoms had lost the qualities like colour, taste, etc., they only occupied space, but geometrical assertions about atoms were admissible and required no further analysis. In modern physics, atoms lose this last property, they possess geometrical qualities in no higher degree than colour, taste, etc. The atom of modern physics can only be symbolized by a partial differential equation in an abstract multidimensional space. Only the experiment of an observer forces the atom to indicate a position, a colour and a quantity of heat. All the qualities of the atom of modern physics are derived, it has no immediate and direct physical properties at all, i.e. every type of visual conception we might wish to design is, eo ipso, faulty. An understanding of 'the first order' is, I would almost say by definition, impossible for the world of atoms.

According to my derivative hypothesis, a change takes place first in the structure of the animal, and this, when sufficiently advanced, may lead to modifications of habits… . “Derivation” holds that every species changes, in time, by virtue of inherent tendencies thereto. “Natural Selection” holds that no such change can take place without the influence of altered external circumstances educing or selecting such change… . The hypothesis of “natural selection” totters on the extension of a conjectural condition, explanatory of extinction to the majority of organisms, and not known or observed to apply to the origin of any species.

According to my views, aiming at quantitative investigations, that is at establishing relations between measurements of phenomena, should take first place in the experimental practice of physics. By measurement to knowledge [door meten tot weten] I should like to write as a motto above the entrance to every physics laboratory.

Accordingly the primordial state of things which I picture is an even distribution of protons and electrons, extremely diffuse and filling all (spherical) space, remaining nearly balanced for an exceedingly long time until its inherent instability prevails. We shall see later that the density of this distribution can be calculated; it was about one proton and electron per litre. There is no hurry for anything to begin to happen. But at last small irregular tendencies accumulate, and evolution gets under way. The first stage is the formation of condensations ultimately to become the galaxies; this, as we have seen, started off an expansion, which then automatically increased in speed until it is now manifested to us in the recession of the spiral nebulae.
As the matter drew closer together in the condensations, the various evolutionary processes followed—evolution of stars, evolution of the more complex elements, evolution of planets and life.

Adam is fading out. It is on account of Darwin and that crowd. I can see that he is not going to last much longer. There's a plenty of signs. He is getting belittled to a germ—a little bit of a speck that you can't see without a microscope powerful enough to raise a gnat to the size of a church. They take that speck and breed from it: first a flea; then a fly, then a bug, then cross these and get a fish, then a raft of fishes, all kinds, then cross the whole lot and get a reptile, then work up the reptiles till you've got a supply of lizards and spiders and toads and alligators and Congressmen and so on, then cross the entire lot again and get a plant of amphibiums, which are half-breeds and do business both wet and dry, such as turtles and frogs and ornithorhyncuses and so on, and cross-up again and get a mongrel bird, sired by a snake and dam'd by a bat, resulting in a pterodactyl, then they develop him, and water his stock till they've got the air filled with a million things that wear feathers, then they cross-up all the accumulated animal life to date and fetch out a mammal, and start-in diluting again till there's cows and tigers and rats and elephants and monkeys and everything you want down to the Missing Link, and out of him and a mermaid they propagate Man, and there you are! Everything ship-shape and finished-up, and nothing to do but lay low and wait and see if it was worth the time and expense.

Adam, the first man, didn’t know anything about the nucleus but Dr. George Gamow, visiting professor from George Washington University, pretends he does. He says for example that the nucleus is 0.00000000000003 feet in diameter. Nobody believes it, but that doesn't make any difference to him.
He also says that the nuclear energy contained in a pound of lithium is enough to run the United States Navy for a period of three years. But to get this energy you would have to heat a mixture of lithium and hydrogen up to 50,000,000 degrees Fahrenheit. If one has a little stove of this temperature installed at Stanford, it would burn everything alive within a radius of 10,000 miles and broil all the fish in the Pacific Ocean.
If you could go as fast as nuclear particles generally do, it wouldn’t take you more than one ten-thousandth of a second to go to Miller's where you could meet Gamow and get more details.

After a tremendous task has been begun in our time, first by Copernicus and then by many very learned mathematicians, and when the assertion that the earth moves can no longer be considered something new, would it not be much better to pull the wagon to its goal by our joint efforts, now that we have got it underway, and gradually, with powerful voices, to shout down the common herd, which really does not weigh arguments very carefully?

After having produced aquatic animals of all ranks and having caused extensive variations in them by the different environments provided by the waters, nature led them little by little to the habit of living in the air, first by the water's edge and afterwards on all the dry parts of the globe. These animals have in course of time been profoundly altered by such novel conditions; which so greatly influenced their habits and organs that the regular gradation which they should have exhibited in complexity of organisation is often scarcely recognisable.

After the discovery of spectral analysis no one trained in physics could doubt the problem of the atom would be solved when physicists had learned to understand the language of spectra. So manifold was the enormous amount of material that has been accumulated in sixty years of spectroscopic research that it seemed at first beyond the possibility of disentanglement. An almost greater enlightenment has resulted from the seven years of Röntgen spectroscopy, inasmuch as it has attacked the problem of the atom at its very root, and illuminates the interior. What we are nowadays hearing of the language of spectra is a true 'music of the spheres' in order and harmony that becomes ever more perfect in spite of the manifold variety. The theory of spectral lines will bear the name of Bohr for all time. But yet another name will be permanently associated with it, that of Planck. All integral laws of spectral lines and of atomic theory spring originally from the quantum theory. It is the mysterious organon on which Nature plays her music of the spectra, and according to the rhythm of which she regulates the structure of the atoms and nuclei.

After what has been premised, I think we may lay down the following Conclusions. First, It is plain Philosophers amuse themselves in vain, when they inquire for any natural efficient Cause, distinct from a Mind or Spirit. Secondly, Considering the whole Creation is the Workmanship of a wise and good Agent, it should seem to become Philosophers, to employ their Thoughts (contrary to what some hold) about the final Causes of Things: And I must confess, I see no reason, why pointing out the various Ends, to which natural Things are adapted and for which they were originally with unspeakable Wisdom contrived, should not be thought one good way of accounting for them, and altogether worthy a Philosopher.

Alchemy. The link between the immemorial magic arts and modern science. Humankind’s first systematic effort to unlock the secrets of matter by reproducible experiment.

Alcmaeon was the first to define the difference between man and animals, saying that man differs from the latter in the fact that he alone has the power of understanding.

Algebra and money are essentially levelers; the first intellectually, the second effectively.

Alike fantastic, if too new, or old;
Be not the first by whom the new are try'd,
Not yet the last to lay the old aside.

All admit that the mountains of the globe are situated mostly along the border regions of the continents (taking these regions as 300 to 1000 miles or more in width), and that over these same areas the sedimentary deposits have, as a general thing, their greatest thickness. At first thought, it would seem almost incredible that the upliftings of mountains, whatever their mode of origin, should have taken place just where the earth’s crust, through these sedimentary accumulations, was the thickest, and where, therefore, there was the greatest weight to be lifted. … Earthquakes show that even now, in this last of the geological ages, the same border regions of the continents, although daily thickening from the sediments borne to the ocean by rivers, are the areas of the greatest and most frequent movements of the earth’s crust. (1866)
[Thus, the facts were known long ago; the explanation by tectonic activity came many decades later.]

All creation is a mine, and every man a miner.
The whole earth, and all within it, upon it, and round about it, including himself … are the infinitely various “leads” from which, man, from the first, was to dig out his destiny.

All fossil anthropoids found hitherto have been known only from mandibular or maxillary fragments, so far as crania are concerned, and so the general appearance of the types they represented had been unknown; consequently, a condition of affairs where virtually the whole face and lower jaw, replete with teeth, together with the major portion of the brain pattern, have been preserved, constitutes a specimen of unusual value in fossil anthropoid discovery. Here, as in Homo rhodesiensis, Southern Africa has provided documents of higher primate evolution that are amongst the most complete extant. Apart from this evidential completeness, the specimen is of importance because it exhibits an extinct race of apes intermediate between living anthropoids and man ... Whether our present fossil is to be correlated with the discoveries made in India is not yet apparent; that question can only be solved by a careful comparison of the permanent molar teeth from both localities. It is obvious, meanwhile, that it represents a fossil group distinctly advanced beyond living anthropoids in those two dominantly human characters of facial and dental recession on one hand, and improved quality of the brain on the other. Unlike Pithecanthropus, it does not represent an ape-like man, a caricature of precocious hominid failure, but a creature well advanced beyond modern anthropoids in just those characters, facial and cerebral, which are to be anticipated in an extinct link between man and his simian ancestor. At the same time, it is equally evident that a creature with anthropoid brain capacity and lacking the distinctive, localised temporal expansions which appear to be concomitant with and necessary to articulate man, is no true man. It is therefore logically regarded as a man-like ape. I propose tentatively, then, that a new family of Homo-simidæ be created for the reception of the group of individuals which it represents, and that the first known species of the group be designated Australopithecus africanus, in commemoration, first, of the extreme southern and unexpected horizon of its discovery, and secondly, of the continent in which so many new and important discoveries connected with the early history of man have recently been made, thus vindicating the Darwinian claim that Africa would prove to be the cradle of mankind.

All geologic history is full of the beginning and the ends of species–of their first and last days; but it exhibits no genealogies of development.

All human affairs follow nature's great analogue, the growth of vegetation. There are three periods of growth in every plant. The first, and slowest, is the invisible growth by the root; the second and much accelerated is the visible growth by the stem; but when root and stem have gathered their forces, there comes the third period, in which the plant quickly flashes into blossom and rushes into fruit.
The beginnings of moral enterprises in this world are never to be measured by any apparent growth. ... At length comes the sudden ripeness and the full success, and he who is called in at the final moment deems this success his own. He is but the reaper and not the labourer. Other men sowed and tilled and he but enters into their labours.

All knowledge resolves itself into probability. ... In every judgment, which we can form concerning probability, as well as concerning knowledge, we ought always to correct the first judgment deriv'd from the nature of the object, by another judgment, deriv'd from the nature of the understanding.

All material Things seem to have been composed of the hard and solid Particles … variously associated with the first Creation by the Counsel of an intelligent Agent. For it became him who created them to set them in order: and if he did so, it is unphilosophical to seek for any other Origin of the World, or to pretend that it might arise out of a Chaos by the mere Laws of Nature.

All of today’s DNA, strung through all the cells of the earth, is simply an extension and elaboration of [the] first molecule.

All other men, being born of woman, have a navel, by reason of the umbilical vessels inserted into it, which from the placenta carry nourishment to children in the womb of their mothers; but it could not be so with our first parents. It cannot be believed that God gave them navels which would have been altogether useless.

All our knowledge derived from observation … is knowledge gotten at first hand. Hereby we see and know things as they are, or as they appear to us; we take the impressions of them on our minds from the original objects themselves which give a clearer and stronger conception of things.

All palaetiological sciences, all speculations which attempt to ascend from the present to the remote past, by the chain of causation, do also, by an inevitable consequence, urge us to look for the beginning of the state of things which we thus contemplate; but in none of these cases have men been able, by the aid of science, to arrive at a beginning which is homogeneous with the known course of events. The first origin of language, of civilization, of law and government, cannot be clearly made out by reasoning and research; and just as little, we may expect, will a knowledge of the origin of the existing and extinct species of plants and animals, be the result of physiological and geological investigation.

All successful men have agreed to one thing,—they were causationists. They believed that things went not by luck, but by law; that there was not a weak or a cracked link in the chain that joins the first and last of things.

All the inventions that the world contains,
Were not by reason first found out, nor brains;
But pass for theirs who had the luck to light
Upon them by mistake or oversight.

All the modern higher mathematics is based on a calculus of operations, on laws of thought. All mathematics, from the first, was so in reality; but the evolvers of the modern higher calculus have known that it is so. Therefore elementary teachers who, at the present day, persist in thinking about algebra and arithmetic as dealing with laws of number, and about geometry as dealing with laws of surface and solid content, are doing the best that in them lies to put their pupils on the wrong track for reaching in the future any true understanding of the higher algebras. Algebras deal not with laws of number, but with such laws of the human thinking machinery as have been discovered in the course of investigations on numbers. Plane geometry deals with such laws of thought as were discovered by men intent on finding out how to measure surface; and solid geometry with such additional laws of thought as were discovered when men began to extend geometry into three dimensions.

All the real true knowledge we have of Nature is intirely experimental, insomuch that, how strange soever the assertion seems, we may lay this down as the first fundamental unerring rule in physics, That it is not within the compass of human understanding to assign a purely speculative reason for any one phaenomenon in nature.

All these delusions of Divination have their root and foundation from Astrology. For whether the lineaments of the body, countenance, or hand be inspected, whether dream or vision be seen, whether marking of entrails or mad inspiration be consulted, there must be a Celestial Figure first erected, by the means of whole indications, together with the conjectures of Signs and Similitudes, they endeavour to find out the truth of what is desired.

All truth passes through three stages. First, it is ridiculed. Second, it is violently opposed. Third, it is accepted as being self-evident. [Caution: expressed in this wording, it is likely misattributed.]

All you really need to know for the moment is that the universe is a lot more complicated than you might think, even if you start from a position of thinking it’s pretty damn complicated in the first place.

All your names I and my friend approve of or nearly all as to sense & expression, but I am frightened by their length & sound when compounded. As you will see I have taken deoxide and skaiode because they agree best with my natural standard East and West. I like Anode & Cathode better as to sound, but all to whom I have shewn them have supposed at first that by Anode I meant No way.

Almost all really new ideas have a certain aspect of foolishness when they are first produced.

Although a science fair can seem like a big “pain” it can help you understand important scientific principles, such as Newton’s First Law of Inertia, which states: “A body at rest will remain at rest until 8:45 p.m. the night before the science fair project is due, at which point the body will come rushing to the body’s parents, who are already in their pajamas, and shout, “I JUST REMEMBERED THE SCIENCE FAIR IS TOMORROW AND WE GOTTA GO TO THE STORE RIGHT NOW!”

Although I was first drawn to math and science by the certainty they promised, today I find the unanswered questions and the unexpected connections at least as attractive.

Although I was four years at the University [of Wisconsin], I did not take the regular course of studies, but instead picked out what I thought would be most useful to me, particularly chemistry, which opened a new world, mathematics and physics, a little Greek and Latin, botany and and geology. I was far from satisfied with what I had learned, and should have stayed longer.
[Enrolled in Feb 1861, left in 1863 without completing a degree, and began his first botanical foot journey.]

Although my Aachen colleagues and students at first regarded the “pure mathematician” with suspicion, I soon had the satisfaction of being accepted a useful member not merely in teaching but also engineering practice; thus I was requested to render expert opinions and to participate in the Ingenieurverein [engineering association].

Although the ocean’s surface seems at first to be completely homogeneous, after half a month we began to differentiate various seas and even different parts of oceans by their characteristic shades. We were astonished to discover that, during an flight, you have to learn anew not only to look, but also to see. At first the finest nuances of color elude you, but gradually your vision sharpens and your color perception becomes richer, and the planet spreads out before you with all its indescribable beauty.

Although [Charles Darwin] would patiently go on repeating experiments where there was any good to be gained, he could not endure having to repeat an experiment which ought, if complete care had been taken, to have told its story at first—and this gave him a continual anxiety that the experiment should not be wasted; he felt the experiment to be sacred, however slight a one it was. He wished to learn as much as possible from an experiment, so that he did not confine himself to observing the single point to which the experiment was directed, and his power of seeing a number of other things was wonderful. ... Any experiment done was to be of some use, and ... strongly he urged the necessity of keeping the notes of experiments which failed, and to this rule he always adhered.

America, so far as her physical history is concerned, has been falsely denominated the New World. Hers was the first dry land lifted out of the waters, hers the first shore washed by the ocean that enveloped all the earth beside; and while Europe was represented only by islands rising here and there above the sea, America already stretched an unbroken line of land from Nova Scotia to the Far West.

Among all the liberal arts, the first is logic, and specifically that part of logic which gives initial instruction about words. … [T]he word “logic” has a broad meaning, and is not restricted exclusively to the science of argumentative reasoning. [It includes] Grammar [which] is “the science of speaking and writing correctly—the starting point of all liberal studies.”

An acquaintance of mine, a notary by profession, who, by perpetual writing, began first to complain of an excessive wariness of his whole right arm which could be removed by no medicines, and which was at last succeeded by a perfect palsy of the whole arm. … He learned to write with his left hand, which was soon thereafter seized with the same disorder.

An amino acid residue (other than glycine) has no symmetry elements. The general operation of conversion of one residue of a single chain into a second residue equivalent to the first is accordingly a rotation about an axis accompanied by translation along the axis. Hence the only configurations for a chain compatible with our postulate of equivalence of the residues are helical configurations.
[Co-author with American chemist, ert B. Corey (1897-1971) and H. R. Branson]

An idea must not be condemned for being a little shy and incoherent; all new ideas are shy when introduced first among our old ones. We should have patience and see whether the incoherency is likely to wear off or to wear on, in which latter case the sooner we get rid of them the better.

An idea must not be condemned for being a little shy and incoherent; all new ideas are shy when introduced first among our old ones. We should have patience and see whether the incoherency is likely to wear off or to wear on, in which latter case the sooner we get rid of them the better.

An important fact, an ingenious aperçu, occupies a very great number of men, at first only to make acquaintance with it; then to understand it; and afterwards to work it out and carry it further.

An old French geometer used to say that a mathematical theory was never to be considered complete till you had made it so clear that you could explain it to the first man you met in the street.

Anaxagoras of Clazomenae, son of Hegesiboulos, held that the first principles of things were the homoeomeries. For it seemed to him quite impossible that anything should come into being from the non-existent or be dissolved into it. Anyhow we take in nourishment which is simple and homogeneous, such as bread or water, and by this are nourished hair, veins, arteries, flesh, sinews, bones and all the other parts of the body. Which being so, we must agree that everything that exists is in the nourishment we take in, and that everything derives its growth from things that exist. There must be in that nourishment some parts that are productive of blood, some of sinews, some of bones, and so on-parts which reason alone can apprehend. For there is no need to refer the fact that bread and water produce all these things to sense-perception; rather, there are in bread and water parts which only reason can apprehend.

Anaximander son of Praxiades, of Miletus: he said that the principle and element is the Indefinite, not distinguishing air or water or anything else. … he was the first to discover a gnomon, and he set one up on the Sundials (?) in Sparta, according to Favorinus in his Universal History, to mark solstices and equinoxes; and he also constructed hour indicators. He was the first to draw an outline of earth and sea, but also constructed a [celestial] globe. Of his opinions he made a summary exposition, which I suppose Apollodorus the Athenian also encountered. Apollodorus says in his Chronicles that Anaximander was sixty-four years old in the year of the fifty-eighth Olympiad [547/6 B.C.], and that he died shortly afterwards (having been near his prime approximately during the time of Polycrates, tyrant of Samos).

Anaximander the Milesian, a disciple of Thales, first dared to draw the inhabited world on a tablet; after him Hecataeus the Milesian, a much-travelled man, made the map more accurate, so that it became a source of wonder.

And for rejecting such a Medium, we have the Authority of those the oldest and most celebrated Philosophers of Greece and Phoenicia, who made a Vacuum, and Atoms, and the Gravity of Atoms, the first Principles of their Philosophy; tacitly attributing Gravity to some other Cause than dense Matter. Later Philosophers banish the Consideration of such a Cause out of natural Philosophy, feigning Hypotheses for explaining all things mechanically, and referring other Causes to Metaphysicks: Whereas the main Business of natural Philosophy is to argue from Phaenomena without feigning Hypotheses, and to deduce Causes from Effects, till we come to the very first Cause, which certainly is not mechanical; and not only to unfold the Mechanism of the World, but chiefly to resolve these and such like Questions. What is there in places almost empty of Matter, and whence is it that the Sun and Planets gravitate towards one another, without dense Matter between them? Whence is it that Nature doth nothing in vain; and whence arises all that Order and Beauty which we see in the World? ... does it not appear from phaenomena that there is a Being incorporeal, living, intelligent, omnipresent, who in infinite space, as it were in his Sensory, sees the things themselves intimately, and thoroughly perceives them, and comprehends them wholly by their immediate presence to himself.

And if you want the exact moment in time, it was conceived mentally on 8th March in this year one thousand six hundred and eighteen, but submitted to calculation in an unlucky way, and therefore rejected as false, and finally returning on the 15th of May and adopting a new line of attack, stormed the darkness of my mind. So strong was the support from the combination of my labour of seventeen years on the observations of Brahe and the present study, which conspired together, that at first I believed I was dreaming, and assuming my conclusion among my basic premises. But it is absolutely certain and exact that the proportion between the periodic times of any two planets is precisely the sesquialterate proportion of their mean distances.

André Weil suggested that there is a logarithmic law at work: first-rate people attract other first-rate people, but second-rate people tend to hire third-raters, and third-rate people hire fifth-raters. If a dean or a president is genuinely interested in building and maintaining a high-quality university (and some of them are), then he must not grant complete self-determination to a second-rate department; he must, instead, use his administrative powers to intervene and set things right. That’s one of the proper functions of deans and presidents, and pity the poor university in which a large proportion of both the faculty and the administration are second-raters; it is doomed to diverge to minus infinity.

Anybody who looks at living organisms knows perfectly well that they can produce other organisms like themselves. This is their normal function, they wouldn’t exist if they didn’t do this, and it’s not plausible that this is the reason why they abound in the world. In other words, living organisms are very complicated aggregations of elementary parts, and by any reasonable theory of probability or thermodynamics highly improbable. That they should occur in the world at all is a miracle of the first magnitude; the only thing which removes, or mitigates, this miracle is that they reproduce themselves. Therefore, if by any peculiar accident there should ever be one of them, from there on the rules of probability do not apply, and there will be many of them, at least if the milieu is reasonable. But a reasonable milieu is already a thermodynamically much less improbable thing. So, the operations of probability somehow leave a loophole at this point, and it is by the process of self-reproduction that they are pierced.

Anyone who tries to make a distinction between education and entertainment doesn’t know the first thing about either.

Anything worth doing is worth doing twice, the first time quick and dirty and the second time the best way you can.

Are you aware that humanity is just a blip? Not even a blip. Just a fraction of a fraction of what the universe has been and will become? Talk about perspective. I figure I can’t feel so entirely stupid about saying what I said because, first of all, it’s true. And second of all, there will be no remnant of me or my stupidity. No fossil or geographical shift that can document, really, even the most important historical human beings, let alone my paltry admissions.

Arithmetic is the first of the sciences and the mother of safety.

Art and religion first; then philosophy; lastly science. That is the order of the great subjects of life, that’s their order of importance.

As a second year high school chemistry student, I still have a vivid memory of my excitement when I first saw a chart of the periodic table of elements. The order in the universe seemed miraculous, and I wanted to study and learn as much as possible about the natural sciences.

As an Art, Mathematics has its own standard of beauty and elegance which can vie with the more decorative arts. In this it is diametrically opposed to a Baroque art which relies on a wealth of ornamental additions. Bereft of superfluous addenda, Mathematics may appear, on first acquaintance, austere and severe. But longer contemplation reveals the classic attributes of simplicity relative to its significance and depth of meaning.

As every circumstance relating to so capital a discovery as this (the greatest, perhaps, that has been made in the whole compass of philosophy, since the time of Sir Isaac Newton) cannot but give pleasure to all my readers, I shall endeavour to gratify them with the communication of a few particulars which I have from the best authority. The Doctor [Benjamin Franklin], after having published his method of verifying his hypothesis concerning the sameness of electricity with the matter lightning, was waiting for the erection of a spire in Philadelphia to carry his views into execution; not imagining that a pointed rod, of a moderate height, could answer the purpose; when it occurred to him, that, by means of a common kite, he could have a readier and better access to the regions of thunder than by any spire whatever. Preparing, therefore, a large silk handkerchief, and two cross sticks, of a proper length, on which to extend it, he took the opportunity of the first approaching thunder storm to take a walk into a field, in which there was a shed convenient for his purpose. But dreading the ridicule which too commonly attends unsuccessful attempts in science, he communicated his intended experiment to no body but his son, who assisted him in raising the kite.
The kite being raised, a considerable time elapsed before there was any appearance of its being electrified. One very promising cloud passed over it without any effect; when, at length, just as he was beginning to despair of his contrivance, he observed some loose threads of the hempen string to stand erect, and to avoid one another, just as if they had been suspended on a common conductor. Struck with this promising appearance, he inmmediately presented his knuckle to the key, and (let the reader judge of the exquisite pleasure he must have felt at that moment) the discovery was complete. He perceived a very evident electric spark. Others succeeded, even before the string was wet, so as to put the matter past all dispute, and when the rain had wetted the string, he collected electric fire very copiously. This happened in June 1752, a month after the electricians in France had verified the same theory, but before he had heard of any thing that they had done.