[About research with big particle accelerators such as the Large Hadron Collider.] I think the primary justification for this sort of science that we do is fundamental human curiosity. ... It's true, of course, that every previous generation that's made some breakthrough in understanding nature has seen those discoveries translated into new technologies, new possibilities for the human race. That may well happen with the Higgs boson. Quite frankly, at the moment I don't see how you can use the Higgs boson for anything useful.

~~[Orphan]~~ All the significant breakthroughs were break-withs old ways of thinking.

And yet in a funny way our lack of success led to our breakthrough; because, since we could not get a cell line off the shelf doing what we wanted, we were forced to construct it. And the original experiment ... developed into a method for the production of hybridomas ... [which] was of more importance than our original purpose.

Applied research generates improvements, not breakthroughs. Great scientific advances spring from pure research. Even scientists renowned for their “useful” applied discoveries often achieved success only when they abandoned their ostensible applied-science goal and allowed their minds to soar—as when Alexander Fleming, “just playing about,” refrained from throwing away green molds that had ruined his experiment, studied them, and discovered penicillin. Or when C. A. Clarke, a physician affiliated with the University of Liverpool, became intrigued in the 1950s by genetically created color patterns that emerged when he cross-bred butterflies as a hobby. His fascination led him—“by the pleasant route of pursuing idle curiosity”—to the successful idea for preventing the sometimes fatal anemia that threatened babies born of a positive-Rhesus-factor father and a negative-Rhesus-factor mother.

Chance throws peculiar conditions in everyone's way. If we apply intelligence, patience and special vision, we are rewarded with new creative breakthroughs.

Even in the dark times between experimental breakthroughs, there always continues a steady evolution of theoretical ideas, leading almost imperceptibly to changes in previous beliefs.

Ever so often in the history of human endeavour, there comes a breakthrough that takes humankind across a frontier into a new era. ... today's announcement is such a breakthrough, a breakthrough that opens the way for massive advancement in the treatment of cancer and hereditary diseases. And that is only the beginning.

Formula for breakthroughs in research: Take young researchers, put them together in virtual seclusion, give them an unprecedented degree of freedom and turn up the pressure by fostering competitiveness.

I like to find mavericks, students who don’t know what they’re looking for, who are sensitive and vulnerable and have unusual pasts. If you do enough work with these students you can often transform their level of contribution. After all, the real breakthroughs come from the mavericks.

I’m convinced that the best solutions are often the ones that are counterintuitive—that challenge conventional thinking—and end in breakthroughs. It is always easier to do things the same old way … why change? To fight this, keep your dissatisfaction index high and break with tradition. Don’t be too quick to accept the way things are being done. Question whether there’s a better way. Very often you will find that once you make this break from the usual way - and incidentally, this is probably the hardest thing to do—and start on a new track your horizon of new thoughts immediately broadens. New ideas flow in like water. Always keep your interests broad - don’t let your mind be stunted by a limited view.

I’m on the verge of a major breakthrough, but I’m also at the point where physics ends and chemistry begins, so I’ll have to drop the whole thing,

If the great story of the last century was the conflict among various political ideologies—communism, fascism and democracy—then the great narrative of this century will be the changes wrought by astonishing scientific breakthroughs

Modern technology has lost its magic. No longer do people stand in awe, thrilled by the onward rush of science, the promise of a new day. Instead, the new is suspect. It arouses our hostility as much as it used to excite our fancy. With each breakthrough there are recurrent fears and suspicion. How will the advance further pollute our lives; modern technology is not merely what it first appears to be. Behind the white coats, the disarming jargon, the elaborate instrumentation, and at the core of what has often seemed an automatic process, one finds what Dorothy found in Oz: modern technology is human after all.

Perhaps ’twas an apple fell from a tree,
That inspired young Isaac, to see.
  The law of gravity it sparked,
  A breakthrough, it marked,
And physics was changed, eternally!

Perhaps I can best describe my experience of doing mathematics in terms of a journey through a dark unexplored mansion. You enter the first room of the mansion and it’s completely dark. You stumble around bumping into the furniture, but gradually you learn where each piece of furniture is. Finally, after six months or so, you find the light switch, you turn it on, and suddenly it’s all illuminated. You can see exactly where you were. Then you move into the next room and spend another six months in the dark. So each of these breakthroughs, while sometimes they’re momentary, sometimes over a period of a day or two, they are the culmination of—and couldn’t exist without—the many months of stumbling around in the dark that proceed them.

The National Science Foundation asked the great “breakthrough” scientists what they felt to be the most dominantly favorable factor in their educational experience. The answer was almost uniformly, “Intimate association with a great, inspiring teacher.”

The transistor came about because fundamental knowledge had developed to a stage where human minds could understand phenomena that had been observed for a long time. In the case of a device with such important consequences to technology, it is noteworthy that a breakthrough came from work dedicated to the understanding of fundamental physical phenomena, rather than the cut-and-try method of producing a useful device.

We are a caring nation, and our values should also guide us on how we harness the gifts of science. New medical breakthroughs bring the hope of cures for terrible diseases and treatments that can improve the lives of millions. Our challenge is to make sure that science serves the cause of humanity instead of the other way around.