...after my first feeling of revulsion had passed, I spent three of the most entertaining and instructive weeks of my life studying the fascinating molds which appeared one by one on the slowly disintegrating mass of horse-dung. Microscopic molds are both very beautiful and absorbingly interesting. The rapid growth of their spores, the way they live on each other, the manner in which the different forms come and go, is so amazing and varied that I believe a man could spend his life and not exhaust the forms or problems contained in one plate of manure.

A bit of mould is a pleiad of flowers; a nebula is an ant-hill of stars.

A general State education is a mere contrivance for moulding people to be exactly like one another: and as the mould in which it casts them is that which pleases the predominant power in the government, whether this be a monarch, a priesthood, an aristocracy, or the majority of the existing generation in proportion as it is efficient and successful, it establishes a despotism over the mind, leading by a natural tendency to one over the body.

After innumerable dynasties of giant creatures, after endless generations of fish and families of molluscs, man finally arrives, the degenerate product of a grandiose type, his mould perhaps broken by his Creator. Fired by his retrospection, these timid humans, born but yesterday, can now leap across chaos, sing an endless hymn, and configure the history of the universe in a sort of retrograde Apocalypse.

Applied research generates improvements, not breakthroughs. Great scientific advances spring from pure research. Even scientists renowned for their “useful” applied discoveries often achieved success only when they abandoned their ostensible applied-science goal and allowed their minds to soar—as when Alexander Fleming, “just playing about,” refrained from throwing away green molds that had ruined his experiment, studied them, and discovered penicillin. Or when C. A. Clarke, a physician affiliated with the University of Liverpool, became intrigued in the 1950s by genetically created color patterns that emerged when he cross-bred butterflies as a hobby. His fascination led him—“by the pleasant route of pursuing idle curiosity”—to the successful idea for preventing the sometimes fatal anemia that threatened babies born of a positive-Rhesus-factor father and a negative-Rhesus-factor mother.

Children [are] born with a zest for knowledge, aware that they must live in a future molded by science, but so often convinced by their culture that science is not for them.

Examining this water...I found floating therein divers earthy particles, and some green streaks, spirally wound serpent-wise...and I judge that some of these little creatures were above a thousand times smaller than the smallest ones I have ever yet seen, upon the rind of cheese, in wheaten flour, mould, and the like.
[The first recorded observation of protozoa.]

For me, the first challenge for computing science is to discover how to maintain order in a finite, but very large, discrete universe that is intricately intertwined. And a second, but not less important challenge is how to mould what you have achieved in solving the first problem, into a teachable discipline: it does not suffice to hone your own intellect (that will join you in your grave), you must teach others how to hone theirs. The more you concentrate on these two challenges, the clearer you will see that they are only two sides of the same coin: teaching yourself is discovering what is teachable.

From packaging materials, through fibers, foams and surface coatings, to continuous extrusions and large-scale moldings, plastics have transformed almost every aspect of life. Without them, much of modern medicine would be impossible and the consumer electronics and computer industries would disappear. Plastic sewage and water pipes alone have made an immeasurable contribution to public health worldwide.

Genius can only breathe freely in an atmosphere of freedom. Persons of genius are, ex vi termini, more individual than any other people—less capable, consequently, of fitting themselves, without hurtful compression, into any of the small number of moulds which society provides in order to save its members the trouble of forming their own character.

I am very fond of the oyster shell. It is humble and awkward and ugly. It is slate-colored and unsymmetrical. Its form is not primarily beautiful but functional. I make fun of its knobbiness. Sometimes I resent its burdens and excrescences. But its tireless adaptability and tenacity draw my astonished admiration and sometimes even my tears. And it is comfortable in its familiarity, its homeliness, like old garden gloves when have molded themselves perfectly to the shape of the hand.

I doubt that Fleming could have obtained a grant for the discovery of penicillin on that basis [a requirement for highly detailed research plans] because he could not have said, 'I propose to have an accident in a culture so that it will be spoiled by a mould falling on it, and I propose to recognize the possibility of extracting an antibiotic from this mould.'

I will now direct the attention of scientists to a previously unnoticed cause which brings about the metamorphosis and decomposition phenomena which are usually called decay, putrefaction, rotting, fermentation and moldering. This cause is the ability possessed by a body engaged in decomposition or combination, i.e. in chemical action, to give rise in a body in contact with it the same ability to undergo the same change which it experiences itself.

If an explanation is so vague in its inherent nature, or so unskillfully molded in its formulation, that specific deductions subject to empirical verification or refutation can not be based upon it, then it can never serve as a working hypothesis. A hypothesis with which one can not work is not a working hypothesis.

If the structure that serves as a template (the gene or virus molecule) consists of, say, two parts, which are themselves complementary In structure, then each of these parts can serve as the mould for the production of a replica of the other part, and the complex of two complementary parts thus can serve as the mould for the production of duplicates of itself.

It was astonishing that for some considerable distance around the mould growth the staphococcal colonies were undergoing lysis. What had formerly been a well-grown colony was now a faint shadow of its former self...I was sufficiently interested to pursue the subject.
[Sep 1928, the first observation of penicillin. Lysis is the dissolution or destruction of cells.]

Mutations and chromosomal changes arise in every sufficiently studied organism with a certain finite frequency, and thus constantly and unremittingly supply the raw materials for evolution. But evolution involves something more than origin of mutations. Mutations and chromosomal changes are only the first stage, or level, of the evolutionary process, governed entirely by the laws of the physiology of individuals. Once produced, mutations are injected in the genetic composition of the population, where their further fate is determined by the dynamic regularities of the physiology of populations. A mutation may be lost or increased in frequency in generations immediately following its origin, and this (in the case of recessive mutations) without regard to the beneficial or deleterious effects of the mutation. The influences of selection, migration, and geographical isolation then mold the genetic structure of populations into new shapes, in conformity with the secular environment and the ecology, especially the breeding habits, of the species. This is the second level of the evolutionary process, on which the impact of the environment produces historical changes in the living population.

My father’s collection of fossils was practically unnamed, but the appearance of Phillips’ book [Geology of the Yorkshire Coast], in which most of our specimens were figured, enabled us to remedy this defect. Every evening was devoted by us to accomplishing the work. This was my first introduction to true scientific study. … Phillips’ accurate volume initiated an entirely new order of things. Many a time did I mourn over the publication of this book, and the consequences immediately resulting from it. Instead of indulging in the games and idleness to which most lads are prone, my evenings throughout a long winter were devoted to the detested labour of naming these miserable stones. Such is the short-sightedness of boyhood. Pursuing this uncongenial work gave me in my thirteenth year a thorough practical familiarity with the palaeontological treasures of Eastern Yorkshire. This early acquisition happily moulded the entire course of my future life.

Oh! That the Chemist’s magic art
Could crystallize this sacred treasure!…
That very law which moulds a tear,
And bids it trickle from its source;
That law preserves the earth a sphere,
And guides the planets in their course.

Our remote ancestors tried to interpret nature in terms of anthropomorphic concepts of their own creation and failed. The efforts of our nearer ancestors to interpret nature on engineering lines proved equally inadequate. Nature refused to accommodate herself to either of these man-made moulds. On the other hand, our efforts to interpret nature in terms of the concepts of pure mathematics have, so far, proved brilliantly successful. It would now seem to be beyond dispute that in some way nature is more closely allied to the concepts of pure mathematics than to those of biology or of engineering, and…the mathematical interpretation…fits objective nature incomparably better than the two previously tried.

Pope has elegantly said a perfect woman's but a softer man. And if we take in the consideration, that there can be but one rule of moral excellence for beings made of the same materials, organized after the same manner, and subjected to similar laws of Nature, we must either agree with Mr. Pope, or we must reverse the proposition, and say, that a perfect man is a woman formed after a coarser mold.

Reality is never skin-deep. The true nature of the earth and its full wealth of hidden treasures cannot be argued from the visible rocks, the rocks upon which we live and out of which we make our living. The face of the earth, with its upstanding continents and depressed ocean-deeps, its vast ornament of plateau and mountain-chain, is molded by structure and process in hidden depths.

Stay in college, get the knowledge. And stay there until you’re through. If they can make penicillin out of moldy bread, they can sure make something out of you.
Advice to a young person to continue his education.

The active agent is readily filterable and the name “penicillin” has been given to filtrates of broth cultures of the mould. … It is suggested that it may be an efficient antiseptic for application to, or injection into, areas infected with penicillin-sensitive microbes.

The computational formalism of mathematics is a thought process that is externalised to such a degree that for a time it becomes alien and is turned into a technological process. A mathematical concept is formed when this thought process, temporarily removed from its human vessel, is transplanted back into a human mold. To think ... means to calculate with critical awareness.

The faculty for remembering is not diminished in proportion to what one has learnt, just as little as the number of moulds in which you cast sand lessens its capacity for being cast in new moulds.

The mutton in the study gathered over it a thick blanket of Penicillium. On the 13th [December 1875] it had assumed a light brown colour as if by a faint admixture of clay; but the infusion became transparent. The ‘clay’ here was the slime of dead or dormant Bacteria, the cause of their quiescence being the blanket of Penicillium. I found no active life in this tube, while all the others swarmed with Bacteria. In every case where the mould was thick and coherent the Bacteria died, or became dormant, and fell to the bottom of the sediment … The Bacteria which manufacture a green pigment appear to be uniformly victorious in their fight with the Penicillium.

The particles of a dew-drop and the masses of a planet are moulded and controlled by the same force.

The preservation of a few samples of undeveloped territory is one of the most clamant issues before us today. Just a few more years of hesitation and the only trace of that wilderness which has exerted such a fundamental influence in molding American character will lie in the musty pages of pioneer books. … To avoid this catastrophe demands immediate action.

The ravages committed by man subvert the relations and destroy the balance which nature had established between her organized and her inorganic creations; and she avenges herself upon the intruder, by letting loose upon her defaced provinces destructive energies hitherto kept in check by organic forces destined to be his best auxiliaries, but which he has unwisely dispersed and driven from the field of action. When the forest is gone, the great reservoir of moisture stored up in its vegetable mould is evaporated, and returns only in deluges of rain to wash away the parched dust into which that mould has been converted. The well-wooded and humid hills are turned to ridges of dry rock, which encumbers the low grounds and chokes the watercourses with its debris, and–except in countries favored with an equable distribution of rain through the seasons, and a moderate and regular inclination of surface–the whole earth, unless rescued by human art from the physical degradation to which it tends, becomes an assemblage of bald mountains, of barren, turfless hills, and of swampy and malarious plains. There are parts of Asia Minor, of Northern Africa, of Greece, and even of Alpine Europe, where the operation of causes set in action by man has brought the face of the earth to a desolation almost as complete as that of the moon; and though, within that brief space of time which we call “the historical period,” they are known to have been covered with luxuriant woods, verdant pastures, and fertile meadows, they are now too far deteriorated to be reclaimable by man, nor can they become again fitted for human use, except through great geological changes, or other mysterious influences or agencies of which we have no present knowledge, and over which we have no prospective control. The earth is fast becoming an unfit home for its noblest inhabitant, and another era of equal human crime and human improvidence, and of like duration with that through which traces of that crime and that improvidence extend, would reduce it to such a condition of impoverished productiveness, of shattered surface, of climatic excess, as to threaten the depravation, barbarism, and perhaps even extinction of the species.

The sciences and arts are not cast in a mold, but formed and shaped little by little, by repeated handling and polishing, as bears lick their cubs into shape at leisure.

There is as much difference between a collection of mentally free citizens and a community molded by modern methods of propaganda as there is between a heap of raw materials and a battleship.

There is in Nature a general prototype in each species on which each individual is modeled, but which seems, in realizing itself, to alter itself or perfect itself according to circumstances. So that, relative to certain qualities, this is an extraordinary appearing variation in the succession of these individuals, and at the same time a constancy which appears wonderful in the entire species. The first animal, the first horse, for example, has been the external model and the interieur mold on which all horses which have been born, all those which now exist, and all those which will be born have been formed.

This notion that “science” is something that belongs in a separate compartment of its own, apart from everyday life, is one that I should like to challenge. We live in a scientific age; yet we assume that knowledge of science is the prerogative of only a small number of human beings, isolated and priest-like in their laboratories. This is not true. It cannot be true. The materials of science are the materials of life itself. Science is part of the reality of living; it is the what, the how, and the why of everything in our experience. It is impossible to understand man without understanding his environment and the forces that have molded him physically and mentally.

We [are] God’s forgotten Science Fair project, left to grow mold.

We do not inhabit a perfected world where natural selection ruthlessly scrutinizes all organic structures and then molds them for optimal utility. Organisms inherit a body form and a style of embryonic development; these impose constraint s upon future change and adaptation. In many cases, evolutionary pathways reflect inherited patterns more than current environmental demands. These inheritances constrain, but they also provide opportunity. A potentially minor genetic change ... entails a host of complex, nonadaptive consequences ... What ‘play’ would evolution have if each structure were built for a restricted purpose and could be used for nothing else? How could humans learn to write if our brain had not evolved for hunting, social cohesion, or whatever, and could not transcend the adaptive boundaries of its original purpose?

We should like to propose instead that the specificity of DNA self replication is accomplished without recourse to specific protein synthesis and that each of our complementary DNA chains serves as a template or mould for the formation onto itself of a new companion chain.
[Co-author with Francis Crick]