[Fossils found in the Secondary formation are] unrefined and imperfect [species and the species in the Tertiary formation] are very perfect and wholly similar to those that are seen in the modern sea. [Thus] as many ages have elapsed during the elevation of the Alps, as there are races of organic fossil bodies embedded within the strata.

[My uncle said to me…] When I read, forty years ago, that shells from Syria were found in the Alps, I say, I admit, with a slightly mocking tone, that these shells were apparently brought by pilgrims who were returning from Jerusalem. M. de Buffon reprimanded me very sharply in his Theory of the Earth, page 281. I did not want to quarrel with him over shells, but I remain of the same opinion, because the impossibility that the sea formed the mountains is evident to me. Some may tell me that porphyry is made of sea urchin spikes, I’ll believe it when I see white marble is made of ostrich feathers.

[The Big Bang is] followed by what? By a dull-as-ditchwater expansion which degrades itself adiabatically until it is incapable of doing anything at all. The notion that galaxies form, to be followed by an active astronomical history, is an illusion. Nothing forms, the thing is as dead as a door-nail.

[The earth’s rocks] were so arranged, in their formation, that they should best serve Man’s purposes. The strata were subjected to metamorphism, and so crystallized, that he might be provided with the most perfect material for his art, his statues, temples, and dwellings; at the same time, they were filled with veins, in order to supply him with gold and silver and other treasures. The rocks were also made to enclose abundant beds of coal and iron ore, that Man might have fuel for his hearths and iron for his utensils and machinery. Mountains were raised to temper hot climates, to diversify the earth’s productiveness, and, pre-eminently, to gather the clouds into river-channels, thence to moisten the fields for agriculture, afford facilities for travel, and supply the world with springs and fountains.

[There is an] immense advantage to be gained by ample space and appropriate surroundings in aiding the formation of a just idea of the beauty and interest of each specimen... Nothing detracts so much from the enjoyment ... from a visit to a museum as the overcrowding of the specimens exhibited.

Are coral reefs growing from the depths of the oceans? ... [The] reply is a simple negative; and a single fact establishes its truth. The reef-forming coral zoophytes, as has been shown, cannot grow at greater depths than 100 or 120 feet; and therefore in seas deeper than this, the formation or growth of reefs over the bottom is impossible.

Il est impossible de contempler le spectacle de l’univers étoilé sans se demander comment il s’est formé: nous devions peut-être attendre pour chercher une solution que nous ayons patiemment rassemblé les éléments …mais si nous étions si raisonnables, si nous étions curieux sans impatience, il est probable que nous n’avions jamais créé la Science et que nous nous serions toujours contentés de vivre notre petite vie. Notre esprit a donc reclamé impérieusement cette solution bien avant qu’elle fut mûre, et alors qu’il ne possédait que de vagues lueurs, lui permettant de la deviner plutôt que de l’attendre.
It is impossible to contemplate the spectacle of the starry universe without wondering how it was formed: perhaps we ought to wait, and not look for a solution until have patiently assembled the elements … but if we were so reasonable, if we were curious without impatience, it is probable we would never have created Science and we would always have been content with a trivial existence. Thus the mind has imperiously laid claim to this solution long before it was ripe, even while perceived in only faint glimmers—allowing us to guess a solution rather than wait for it.

Question: State what are the conditions favourable for the formation of dew. Describe an instrument for determining the dew point, and the method of using it.
Answer: This is easily proved from question 1. A body of gas as it ascends expands, cools, and deposits moisture; so if you walk up a hill the body of gas inside you expands, gives its heat to you, and deposits its moisture in the form of dew or common sweat. Hence these are the favourable conditions; and moreover it explains why you get warm by ascending a hill, in opposition to the well-known law of the Conservation of Energy.

Question: What is the difference between a “real” and a “virtual” image? Give a drawing showing the formation of one of each kind.
Answer: You see a real image every morning when you shave. You do not see virtual images at all. The only people who see virtual images are those people who are not quite right, like Mrs. A. Virtual images are things which don't exist. I can't give you a reliable drawing of a virtual image, because I never saw one.

The classification of facts, the recognition of their sequence and relative significance is the function of science, and the habit of forming a judgment upon these facts unbiassed by personal feeling is characteristic of what may be termed the scientific frame of mind.

~~[Attributed, authorship undocumented]~~ Mathematical demonstrations are a logic of as much or more use, than that commonly learned at schools, serving to a just formation of the mind, enlarging its capacity, and strengthening it so as to render the same capable of exact reasoning, and discerning truth from falsehood in all occurrences, even in subjects not mathematical. For which reason it is said, the Egyptians, Persians, and Lacedaemonians seldom elected any new kings, but such as had some knowledge in the mathematics, imagining those, who had not, men of imperfect judgments, and unfit to rule and govern.

A noteworthy and often-remarked similarity exists between the facts and methods of geology and those of linguistic study. The science of language is, as it were, the geology of the most modern period, the Age of the Man, having for its task to construct the history of development of the earth and its inhabitants from the time when the proper geological record remains silent … The remains of ancient speech are like strata deposited in bygone ages, telling of the forms of life then existing, and of the circumstances which determined or affected them; while words are as rolled pebbles, relics of yet more ancient formations, or as fossils, whose grade indicates the progress of organic life, and whose resemblances and relations show the correspondence or sequence of the different strata; while, everywhere, extensive denudation has marred the completeness of the record, and rendered impossible a detailed exhibition of the whole course of development.

Absorbed in the special investigation, I paid no heed to the edifice which was meanwhile unconsciously building itself up. Having however completed the comparison of the fossil species in Paris, I wanted, for the sake of an easy revision of the same, to make a list according to their succession in geological formations, with a view of determining the characteristics more exactly and bringing them by their enumeration into bolder relief. What was my joy and surprise to find that the simplest enumeration of the fossil fishes according to their geological succession was also a complete statement of the natural relations of the families among themselves; that one might therefore read the genetic development of the whole class in the history of creation, the representation of the genera and species in the several families being therein determined; in one word, that the genetic succession of the fishes corresponds perfectly with their zoological classification, and with just that classification proposed by me.

According to this view of the matter, there is nothing casual in the formation of Metamorphic Rocks. All strata, once buried deep enough, (and due TIME allowed!!!) must assume that state,—none can escape. All records of former worlds must ultimately perish.

Accordingly the primordial state of things which I picture is an even distribution of protons and electrons, extremely diffuse and filling all (spherical) space, remaining nearly balanced for an exceedingly long time until its inherent instability prevails. We shall see later that the density of this distribution can be calculated; it was about one proton and electron per litre. There is no hurry for anything to begin to happen. But at last small irregular tendencies accumulate, and evolution gets under way. The first stage is the formation of condensations ultimately to become the galaxies; this, as we have seen, started off an expansion, which then automatically increased in speed until it is now manifested to us in the recession of the spiral nebulae.
As the matter drew closer together in the condensations, the various evolutionary processes followed—evolution of stars, evolution of the more complex elements, evolution of planets and life.

All of our experience indicates that life can manifest itself only in a concrete form, and that it is bound to certain substantial loci. These loci are cells and cell formations. But we are far from seeking the last and highest level of understanding in the morphology of these loci of life. Anatomy does not exclude physiology, but physiology certainly presupposes anatomy. The phenomena that the physiologist investigates occur in special organs with quite characteristic anatomical arrangements; the various morphological parts disclosed by the anatomist are the bearers of properties or, if you will, of forces probed by the physiologist; when the physiologist has established a law, whether through physical or chemical investigation, the anatomist can still proudly state: This is the structure in which the law becomes manifest.

Anything at all that can be the object of scientific thought becomes dependent on the axiomatic method, and thereby indirectly on mathematics, as soon as it is ripe for the formation of a theory. By pushing ahead to ever deeper layers of axioms … we become ever more conscious of the unity of our knowledge. In the sign of the axiomatic method, mathematics is summoned to a leading role in science.

As for the formation of matter, it is never the product of sudden events, but always the outcome of gradual change.

As I have already mentioned, wherever cells are formed, this tough fluid precedes the first solid structures that indicate the presence of future cells. Moreover, we must assume that this substance furnishes the material for the formation of the nucleus and of the primitive sac, not only because these structures are closely apposed to it, but also because,they react to iodine in the same way. We must assume also that the organization of this substance is the process that inaugurates the formation of new cells. It therefore seems justifiable for me to propose a name that refers to its physiological function: I propose the word protoplasma.

But I think that in the repeated and almost entire changes of organic types in the successive formations of the earth—in the absence of mammalia in the older, and their very rare appearance (and then in forms entirely. unknown to us) in the newer secondary groups—in the diffusion of warm-blooded quadrupeds (frequently of unknown genera) through the older tertiary systems—in their great abundance (and frequently of known genera) in the upper portions of the same series—and, lastly, in the recent appearance of man on the surface of the earth (now universally admitted—in one word, from all these facts combined, we have a series of proofs the most emphatic and convincing,—that the existing order of nature is not the last of an uninterrupted succession of mere physical events derived from laws now in daily operation: but on the contrary, that the approach to the present system of things has been gradual, and that there has been a progressive development of organic structure subservient to the purposes of life.

By the agitation of water and silt, and their gradual accumulation and consolidation... the rocks were formed gradually by the evolution of sediments in water.

Chemistry is not a primitive science like geometry and astronomy; it is constructed from the debris of a previous scientific formation; a formation half chimerical and half positive, itself found on the treasure slowly amassed by the practical discoveries of metallurgy, medicine, industry and domestic economy. It has to do with alchemy, which pretended to enrich its adepts by teaching them to manufacture gold and silver, to shield them from diseases by the preparation of the panacea, and, finally, to obtain for them perfect felicity by identifying them with the soul of the world and the universal spirit.

Combining in our survey then, the whole range of deposits from the most recent to the most ancient group, how striking a succession do they present:– so various yet so uniform–so vast yet so connected. In thus tracing back to the most remote periods in the physical history of our continents, one system of operations, as the means by which many complex formations have been successively produced, the mind becomes impressed with the singleness of nature's laws; and in this respect, at least, geology is hardly inferior in simplicity to astronomy.

Dick Drew took a bunch of misfits—people who wouldn’t fly in formation—and he put together a lab that created technologies that account for 20 percent of 3M's sales in 2000.

GEOLOGY, n. The science of the earth's crust —to which, doubtless, will be added that of its interior whenever a man shall come up garrulous out of a well. The geological formations of the globe already noted are catalogued thus: The Primary, or lower one, consists of rocks, bones of mired mules, gas-pipes, miners' tools, antique statues minus the nose, Spanish doubloons and ancestors. The Secondary is largely made up of red worms and moles. The Tertiary comprises railway tracks, patent pavements, grass, snakes, mouldy boots, beer bottles, tomato cans, intoxicated citizens, garbage, anarchists, snap-dogs and fools.

I definitely deny that any pathological process, i.e. any life-process taking place under unfavourable circumstances, is able to call forth qualitatively new formations lying beyond the customary range of forms characteristic of the species. All pathological formations are either degenerations, transformations, or repetitions of typical physiological structures.

I did enjoy the [CCNY geology] field trips. We went upstate and clambered over formations of synclines and anticlines. We had to diagram them, and figure out their mirror images. If you had an anticline here, you should be able to predict a complementing syncline bulging out somewhere else. Very satisfying when I got it right. Geology allowed me to display my brilliance to my non-college friends. “You know, the Hudson really isn’t a river.” “What are you talking about? … Everybody knows the Hudson River’s a river.” I would explain that the Hudson was a “drowned” river, up to about Poughkeepsie. The Ice Age had depressed the riverbed to a depth that allowed the Atlantic Ocean to flood inland. Consequently, the lower Hudson was really a saltwater estuary.

I have always been very fond of mathematics—for one short period, I even toyed with the possibility of abandoning chemistry in its favour. I enjoyed immensely both its conceptual and formal beauties, and the precision and elegance of its relationships and transformations. Why then did I not succumb to its charms? … because by and large, mathematics lacks the sensuous elements which play so large a role in my attraction to chemistry.I love crystals, the beauty of their forms and formation; liquids, dormant, distilling, sloshing! The fumes, the odors—good or bad, the rainbow of colors; the gleaming vessels of every size, shape and purpose.

I have been driven to assume for some time, especially in relation to the gases, a sort of conducting power for magnetism. Mere space is Zero. One substance being made to occupy a given portion of space will cause more lines of force to pass through that space than before, and another substance will cause less to pass. The former I now call Paramagnetic & the latter are the diamagnetic. The former need not of necessity assume a polarity of particles such as iron has with magnetic, and the latter do not assume any such polarity either direct or reverse. I do not say more to you just now because my own thoughts are only in the act of formation, but this I may say: that the atmosphere has an extraordinary magnetic constitution, & I hope & expect to find in it the cause of the annual & diurnal variations, but keep this to yourself until I have time to see what harvest will spring from my growing ideas.

I have satisfied myself that the [cosmic] rays are not generated by the formation of new matter in space, a process which would be like water running up a hill. Nor do they come to any appreciable amount from the stars. According to my investigations the sun emits a radiation of such penetrative power that it is virtually impossible to absorb it in lead or other substances. ... This ray, which I call the primary solar ray, gives rise to a secondary radiation by impact against the cosmic dust scattered through space. It is the secondary radiation which now is commonly called the cosmic ray, and comes, of course, equally from all directions in space. [The article continues: The phenomena of radioactivity are not the result of forces within the radioactive substances but are caused by this ray emitted by the sun. If radium could be screened effectively against this ray it would cease to be radioactive, he said.]

I should be the last to discard the law of organic heredity ... but the single word “heredity” cannot dispense science from the duty of making every possible inquiry into the mechanism of organic growth and of organic formation. To think that heredity will build organic beings without mechanical means is a piece of unscientific mysticism.

I should like to compare this rearrangement which the proteins undergo in the animal or vegetable organism to the making up of a railroad train. In their passage through the body parts of the whole may be left behind, and here and there new parts added on. In order to understand fully the change we must remember that the proteins are composed of Bausteine united in very different ways. Some of them contain Bausteine of many kinds. The multiplicity of the proteins is determined by many causes, first through the differences in the nature of the constituent Bausteine; and secondly, through differences in the arrangement of them. The number of Bausteine which may take part in the formation of the proteins is about as large as the number of letters in the alphabet. When we consider that through the combination of letters an infinitely large number of thoughts may be expressed, we can understand how vast a number of the properties of the organism may be recorded in the small space which is occupied by the protein molecules. It enables us to understand how it is possible for the proteins of the sex-cells to contain, to a certain extent, a complete description of the species and even of the individual. We may also comprehend how great and important the task is to determine the structure of the proteins, and why the biochemist has devoted himself with so much industry to their analysis.

I tell my students, with a feeling of pride that I hope they will share, that the carbon, nitrogen, and oxygen that make up ninety-nine per cent of our living substance were cooked in the deep interiors of earlier generations of dying stars. Gathered up from the ends of the universe, over billions of years, eventually they came to form, in part, the substance of our sun, its planets, and ourselves. Three billion years ago, life arose upon the earth. It is the only life in the solar system.

I think that the formation of [DNA's] structure by Watson and Crick may turn out to be the greatest developments in the field of molecular genetics in recent years.

I took him [Lawrence Bragg] to a young zoologist working on pattern formation in insect cuticles. The zoologist explained how disturbances introduced into these regular patterns pointed to their formation being governed by some kind of gradient. Bragg listened attentively and then exclaimed: “Your disturbed gradient behaves like a stream of sand running downhill and encountering an obstacle.” “Good heavens,” replied the zoologist, “I had been working on this problem for years before this simple analogy occurred to me and you think of it after twenty minutes.”

If atoms do, by chance, happen to combine themselves into so many shapes, why have they never combined together to form a house or a slipper? By the same token, why do we not believe that if innumerable letters of the Greek alphabet were poured all over the market-place they would eventually happen to form the text of the Iliad?

If we ascribe the ejection of the proton to a Compton recoil from a quantum of 52 x 10⁶ electron volts, then the nitrogen recoil atom arising by a similar process should have an energy not greater than about 400,000 volts, should produce not more than about 10,000 ions, and have a range in the air at N.T.P. of about 1-3mm. Actually, some of the recoil atoms in nitrogen produce at least 30,000 ions. In collaboration with Dr. Feather, I have observed the recoil atoms in an expansion chamber, and their range, estimated visually, was sometimes as much as 3mm. at N.T.P.
These results, and others I have obtained in the course of the work, are very difficult to explain on the assumption that the radiation from beryllium is a quantum radiation, if energy and momentum are to be conserved in the collisions. The difficulties disappear, however, if it be assumed that the radiation consists of particles of mass 1 and charge 0, or neutrons. The capture of the a-particle by the Be⁹ nucleus may be supposed to result in the formation of a C¹² nucleus and the emission of the neutron. From the energy relations of this process the velocity of the neutron emitted in the forward direction may well be about 3 x 10⁹ cm. per sec. The collisions of this neutron with the atoms through which it passes give rise to the recoil atoms, and the observed energies of the recoil atoms are in fair agreement with this view. Moreover, I have observed that the protons ejected from hydrogen by the radiation emitted in the opposite direction to that of the exciting a-particle appear to have a much smaller range than those ejected by the forward radiation.
This again receives a simple explanation on the neutron hypothesis.

If we assume that there is only one enzyme present to act as an oxidizing agent, we must assume for it as many different degrees of activity as are required to explain the occurrence of the various colors known to mendelize (three in mice, yellow, brown, and black). If we assume that a different enzyme or group of enzymes is responsible for the production of each pigment we must suppose that in mice at least three such enzymes or groups of enzymes exist. To determine which of these conditions occurs in mice is not a problem for the biologist, but for the chemist. The biologist must confine his attention to determining the number of distinct agencies at work in pigment formation irrespective of their chemical nature. These agencies, because of their physiological behavior, the biologist chooses to call 'factors,' and attempts to learn what he can about their functions in the evolution of color varieties.

If we consider what science already has enabled men to know—the immensity of space, the fantastic philosophy of the stars, the infinite smallness of the composition of atoms, the macrocosm whereby we succeed only in creating outlines and translating a measure into numbers without our minds being able to form any concrete idea of it—we remain astounded by the enormous machinery of the universe.

In all chemical investigations, it has justly been considered an important object to ascertain the relative weights of the simples which constitute a compound. But unfortunately the enquiry has terminated here; whereas from the relative weights in the mass, the relative weights of the ultimate particles or atoms of the bodies might have been inferred, from which their number and weight in various other compounds would appear, in order to assist and to guide future investigations, and to correct their results. Now it is one great object of this work, to shew the importance and advantage of ascertaining the relative weights of the ultimate particles, both of simple and compound bodies, the number of simple elementary particles which constitute one compound particle, and the number of less compound particles which enter into the formation of one more compound particle.
If there are two bodies, A and B, which are disposed to combine, the following is the order in which the combinations may take place, beginning with the most simple: namely,
1 atom of A + 1 atom of B = 1 atom of C, binary
1 atom of A + 2 atoms of B = 1 atom of D, ternary
2 atoms of A + 1 atom of B = 1 atom of E, ternary
1 atom of A + 3 atoms of B = 1 atom of F, quaternary
3 atoms of A and 1 atom of B = 1 atom of G, quaternary

In October 1838, that is, fifteen months after I had begun my systematic enquiry, I happened to read for amusement Malthus on Population, and being well prepared to appreciate the struggle for existence which everywhere goes on from long-continued observation of the habits of animals and plants, it at once struck me that under these circumstances favourable variations would tend to be, preserved, and unfavourable ones to be destroyed. The result of this would be the formation of new species. Here, then, I had at last got a theory by which to work; but I was so anxious to avoid prejudice, that I determined not for some time to write even the briefest sketch of it.

It has just occurred to me to ask if you are familiar with Lissajous’ experiments. I know nothing about them except what I found in Flammarion’s great “Astronomie Populaire.” One extraordinary chapter on numbers gives diagrams of the vibrations of harmonics—showing their singular relation to the geometrical designs of crystal-formation;—and the chapter is aptly closed by the Pythagorian quotation: Ἀεὶ ὁ θεὸς ὁ μέγας γεωμετρεῖ—“God geometrizes everywhere.” … I should imagine that the geometry of a fine opera would—were the vibrations outlined in similar fashion—offer a network of designs which for intricate beauty would double discount the arabesque of the Alhambra.

It is as true now, as it was in the days when Werner first drew his far-reaching inferences before his charmed listeners, that on the characteristic phenomena and varying distribution of the grand mineral masses of the rock-formations, almost all that concerns the relative habitability of a land depends.

It is obvious that we know with certainty, that the Flütz [layered] and primitive mountains have been produced by a series of precipitations and depositions formed in succession; that they took place from water which covered the globe, existing always more or less generally, and containing the different substances which have been produced from them.

It seems to me that the view toward which we are tending is that the specificity in gene action is always a chemical specificity, probably the production of enzymes which guide metabolic processes along particular channels. A given array of genes thus determines the production of a particular kind of protoplasm with particular properties—such, for example, as that of responding to surface forces by the formation of a special sort of semipermeable membrane, and that of responding to trivial asymmetries in the play of external stimuli by polarization, with consequent orderly quantitative gradients in all physiologic processes. Different genes may now be called into play at different points in this simple pattern, either through the local formation of their specific substrates for action, or by activation of a mutational nature. In either case the pattern becomes more complex and qualitatively differentiated. Successive interactions of differentiated regions and the calling into play of additional genes may lead to any degree of complexity of pattern in the organism as a largely self-contained system. The array of genes, assembled in the course of evolution, must of course be one which determines a highly self­regulatory system of reactions. On this view the genes are highly specific chemically, and thus called into play only under very specific conditions; but their morphological effects, if any, rest on quantitative influences of immediate or remote products on growth gradients, which are resultants of all that has gone on before in the organism.

It was obvious—to me at any rate—that the answer was to why an enzyme is able to speed up a chemical reaction by as much as 10 million times. It had to do this by lowering the energy of activation—the energy of forming the activated complex. It could do this by forming strong bonds with the activated complex, but only weak bonds with the reactants or products.

Lately we have been getting facts pointing to the “oceanic” nature of the floor of so-called inland seas. Through geological investigations it has been definitely established that in its deepest places, for instance, the Caribbean Sea and the Gulf of Mexico, the Earth’s crust is devoid of granite stratum. The same may be said quite confidently about the Mediterranean and the Black Sea. Could the interpretation of these data be that inland seas were the primary stage of the formation of oceanic basins?

Mankind always takes up only such problems as it can solve; since, looking at the matter more closely, we will always find that the problem itself arises only when the material conditions necessary for its solution already exist or are at least in the process of formation.

Modern Science has along with the theory that the Earth dated its beginning with the advent of man, swept utterly away this beautiful imagining. We can, indeed, find no beginning of the world. We trace back events and come to barriers which close our vistabarriers which, for all we know, may for ever close it. They stand like the gates of ivory and of horn; portals from which only dreams proceed; and Science cannot as yet say of this or that dream if it proceeds from the gate of horn or from that of ivory.
In short, of the Earth's origin we have no certain knowledge; nor can we assign any date to it. Possibly its formation was an event so gradual that the beginning was spread over immense periods. We can only trace the history back to certain events which may with considerable certainty be regarded as ushering in our geological era.

More about the selection theory: Jerne meant that the Socratic idea of learning was a fitting analogy for 'the logical basis of the selective theories of antibody formation': Can the truth (the capability to synthesize an antibody) be learned? If so, it must be assumed not to pre-exist; to be learned, it must be acquired. We are thus confronted with the difficulty to which Socrates calls attention in Meno [ ... ] namely, that it makes as little sense to search for what one does not know as to search for what one knows; what one knows, one cannot search for, since one knows it already, and what one does not know, one cannot search for, since one does not even know what to search for. Socrates resolves this difficulty by postulating that learning is nothing but recollection. The truth (the capability to synthesize an antibody) cannot be brought in, but was already inherent.

Most of the beds [of rock] contain shells, corals, and other related forms, called fossils,—so named because dug out of the earth, the word being from the Latin fossilis, meaning, that which is dug up. … The various species that have left their remains in any bed must have been in existence when that bed was in progress of formation…. The study of the fossils of the successive beds is the study of the succession of living species that have existed in the earth’s history.

Mountains have been formed by one [or other] of the causes of the formation of stone, most probably from agglutinative clay which slowly dried and petrified during ages of which we have no record. It seems likely that this habitable world was in former days uninhabitable and, indeed, submerged beneath the ocean. Then, becoming exposed little by little, it petrified in the course of ages.

My present and most fixed opinion regarding the nature of alcoholic fermentation is this: The chemical act of fermentation is essentially a phenomenon correlative with a vital act, beginning and ending with the latter. I believe that there is never any alcoholic fermentation without their being simultaneously the organization, development, multiplication of the globules, or the pursued, continued life of globules which are already formed.

Nature takes as much Pains in the Womb for the forming of a Beggar as an Emperor.

Nature, … in order to carry out the marvelous operations [that occur] in animals and plants has been pleased to construct their organized bodies with a very large number of machines, which are of necessity made up of extremely minute parts so shaped and situated as to form a marvelous organ, the structure and composition of which are usually invisible to the naked eye without the aid of a microscope. … Just as Nature deserves praise and admiration for making machines so small, so too the physician who observes them to the best of his ability is worthy of praise, not blame, for he must also correct and repair these machines as well as he can every time they get out of order.

No anatomist ever discovered a system of organization, calculated to produce pain and disease; or, in explaining the parts of the human body, ever said, this is to irritate; this is to inflame; this duct is to convey the gravel to the kidneys; this gland to secrete the humour which forms the gout: if by chance he come at a part of which he knows not the use, the most he can say is, that it is useless; no one ever suspects that it is put there to incommode, to annoy, or torment.

No collateral science had profited so much by palæontology as that which teaches the structure and mode of formation of the earth’s crust, with the relative position, time, and order of formation of its constituent stratified and unstratified parts. Geology has left her old hand-maiden mineralogy to rest almost wholly on the broad shoulders of her young and vigorous offspring, the science of organic remains.

No conclusion is more fully established, than the important fact of the total absence of any vestiges of the human species throughout the entire series of geological formations.

On the whole, I cannot help saying that it appears to me not a little extraordinary, that a theory so new, and of such importance, overturning every thing that was thought to be the best established in chemistry, should rest on so very narrow and precarious a foundation, the experiments adduced in support of it being not only ambiguous or explicable on either hypothesis, but exceedingly few. I think I have recited them all, and that on which the greatest stress is laid, viz. That of the formation of water from the decomposition of the two kinds of air, has not been sufficiently repeated. Indeed it required so difficult and expensive an apparatus, and so many precautions in the use of it, that the frequent repetition of the experiment cannot be expected; and in these circumstances the practised experimenter cannot help suspecting the accuracy of the result and consequently the certainty of the conclusion.

Organized Fossils are to the naturalist as coins to the antiquary; they are the antiquities of the earth; and very distinctly show its gradual regular formation, with the various changes inhabitants in the watery element.

Pavlov’s data on the two fundamental antagonistic nervous processes—stimulation and inhibition—and his profound generalizations regarding them, in particular, that these processes are parts of a united whole, that they are in a state of constant conflict and constant transition of the one to the other, and his views on the dominant role they play in the formation of the higher nervous activity—all those belong to the most established natural—scientific validation of the Marxist dialectal method. They are in complete accord with the Leninist concepts on the role of the struggle between opposites in the evolution, the motion of matter.

So long as the fur of the beaver was extensively employed as a material for fine hats, it bore a very high price, and the chase of this quadruped was so keen that naturalists feared its speedy consideration. When a Parisian manufacturer invented the silk hat, which soon came into almost universal use, the demand for beavers' fur fell off, and this animal–whose habits, as we have seen, are an important agency in the formation of bogs and other modifications of forest nature–immediately began to increase, reappeared in haunts which we had long abandoned, and can no longer be regarded as rare enough to be in immediate danger of extirpation. Thus the convenience or the caprice of Parisian fashion has unconsciously exercised an influence which may sensibly affect the physical geography of a distant continent.

Take care of your health. ... Imagine Hercules as oarsman in a rotten boat; what can he do there but by the very force of his stroke expedite the ruin of his craft. Take care of the timbers of your boat. ... The formation of right habits is essential to your permanent security. They diminish your chance of falling when assaulted, and they augment your chance of recovery when overthrown.

That the Universe was formed by a fortuitous Concourse of Atoms, I will no more believe than that the accidental Jumbling of the Letters of the Alphabet would fall by Chance into a most ingenious and learned Treatise of Philosophy, Risum teneatis Amici, Hor.

That theory is regarded by some enthusiastic opponents, as already on the threshold of the limbo appointed for exploded hypotheses.

The alternative to the Big Bang is not, in my opinion, the steady state; it is instead the more general theory of continuous creation. Continuous creation can occur in bursts and episodes. These mini-bangs can produce all the wonderful element-building that Fred Hoyle discovered and contributed to cosmology. This kind of element and galaxy formation can take place within an unbounded, non-expanding universe. It will also satisfy precisely the Friedmann solutions of general relativity. It can account very well for all the facts the Big Bang explains—and also for those devastating, contradictory observations which the Big Bang must, at all costs, pretend are not there

The Builder of this Universe was wise,
He plann’d all souls, all systems, planets, particles:
The Plan He shap'd all Worlds and Æons by,
Was—Heavens!—was thy small Nine-and-thirty Articles!

The classification of facts and the formation of absolute judgments upon the basis of this classification—judgments independent of the idiosyncrasies of the individual mind—essentially sum up the aim and method of modern science. The scientific man has above all things to strive at self-elimination in his judgments, to provide an argument which is as true for each individual mind as for his own.

The classification of facts and the formation of absolute judgments upon the basis of this classification—judgments independent of the idiosyncrasies of the individual mind—is peculiarly the scope and method of modern science.

The coal on your grate gives out in decomposing to-day exactly the same amount of light and heat which was taken from the sunshine in its formation in the leaves and boughs of the antediluvian tree.

The complacent manner in which geologists have produced their theories has been extremely amusing; for often with knowledge (and that frequently inaccurate) not extending beyond a given province, they have described the formation of a world with all the detail and air of eye-witnesses. That much good ensues, and that the science is greatly advanced, by the collision of various theories, cannot be doubted. Each party is anxious to support opinions by facts. Thus, new countries are explored, and old districts re-examined; facts come to light that do not suit either party; new theories spring up; and, in the end, a greater insight into the real structure of the earth's surface is obtained.

The development of the nucleoplasm during ontogeny may be to some extent compared to an army composed of corps, which are made up of divisions, and these of brigades, and so on. The whole army may be taken to represent the nucleoplasm of the germ-cell: the earliest cell-division … may be represented by the separation of the two corps, similarly formed but with different duties: and the following cell­divisions by the successive detachment of divisions, brigades, regiments, battalions, companies, etc.; and as the groups become simpler so does their sphere of action become limited.

The development of the Vertebrate proceeds from an axis upward, in two layers, which coalesce at the edges, and also downward, in two layers, which likewise coalesce at the edges. Thus two main tubes are formed, one above the other. During the formation of these, the embryo separates into strata, so that the two main tubes are composed of subordinate tubes which enclose each other as fundamental organs, and are capable of developing into all the organs.

The elementary parts of all tissues are formed of cells in an analogous, though very diversified manner, so that it may be asserted, that there is one universal principle of development for the elementary parts of organisms, however different, and that this principle is the formation of cells.

The energy of a covalent bond is largely the energy of resonance of two electrons between two atoms. The examination of the form of the resonance integral shows that the resonance energy increases in magnitude with increase in the overlapping of the two atomic orbitals involved in the formation of the bond, the word ‘overlapping” signifying the extent to which regions in space in which the two orbital wave functions have large values coincide... Consequently it is expected that of two orbitals in an atom the one which can overlap more with an orbital of another atom will form the stronger bond with that atom, and, moreover, the bond formed by a given orbital will tend to lie in that direction in which the orbital is concentrated.

The formation of planets is like a gigantic snowball fight. The balls bounce off, break apart, or stick together, but in the end they are rolled up into one enormous ball, a planet-ball that has gathered up all the snowflakes in the surrounding area.

The fundamental hypothesis of genetic epistemology is that there is a parallelism between the progress made in the logical and rational organization of knowledge and the corresponding formative psychological processes. With that hypothesis, the most fruitful, most obvious field of study would be the reconstituting of human history—the history of human thinking in prehistoric man. Unfortunately, we are not very well informed in the psychology of primitive man, but there are children all around us, and it is in studying children that we have the best chance of studying the development of logical knowledge, physical knowledge, and so forth.

The fundamental problem in the origin of species is not the origin of differences in appearance, since these arise at the level of the geographical race, but the origin of genetic segregation. The test of species-formation is whether, when two forms meet, they interbreed and merge, or whether they keep distinct.

The genotypic constitution of a gamete or a zygote may be parallelized with a complicated chemico-physical structure. This reacts exclusively in consequence of its realized state, but not in consequence of the history of its creation. So it may be with the genotypical constitution of gametes and zygotes: its history is without influence upon its reactions, which are determined exclusively by its actual nature. The genotype-conception is thus an 'ahistoric' view of the reactions of living beings—of course only as far as true heredity is concerned. This view is an analog to the chemical view, as already pointed out; chemical compounds have no compromising ante-act, H₂O is always H₂O, and reacts always in the same manner, whatsoever may be the 'history' of its formation or the earlier states of its elements. I suggest that it is useful to emphasize this 'radical' ahistoric genotype-conception of heredity in its strict antagonism to the transmission—or phenotype-view.

The information reported in this section [about the two different forms, A and B, of DNA] was very kindly reported to us prior to its publication by Drs Wilkins and Franklin. We are most heavily indebted in this respect to the Kings College Group, and we wish to point out that without this data the formation of the picture would have been most unlikely, if not impossible.
[Co-author with Francis Crick]

The injurious agent in cigarettes comes principally from the burning paper wrapper. The substance thereby formed is called “acrolein.” It has a violent action on the nerve centers, producing degeneration of the cells of the brain, which is quite rapid among boys. Unlike most narcotics, this degeneration is permanent and uncontrollable. I employ no person who smokes cigarettes.
[From the Laboratory of Thomas A. Edison, Orange, N.J., April 26, 1914.]

The instinct for collecting, which began as in other animals as an adaptive property, could always in man spread beyond reason; it could become a hoarding mania. But in its normal form it provides a means of livelihood at the hunting and collecting stage of human evolution. It is then attached to a variety of rational aptitudes, above all in observing, classifying, and naming plants, animals and minerals, skills diversely displayed by primitive peoples. These skills with an instinctive beginning were the foundation of most of the civilised arts and sciences. Attached to other skills in advanced societies they promote the formation of museums and libraries; detached, they lead to acquisition and classification by eccentric individuals, often without any purpose or value at all.

The main steps of my argument may be summarized thus:
1. Organisms are highly coordinated structures.
2. Only certain avenues of change are compatible with their conditions of coordination.
3. The formative and selective action of these internal conditions is theoretically and empirically different from that of Darwinian selection.
4. Mutations in the mode of coordination of the genetic system lie outside the scope of the classical arguments purporting to show that natural selection is the only directive agency.
5. The coordinative conditions constitute a second directive agency.

The principal result of my investigation is that a uniform developmental principle controls the individual elementary units of all organisms, analogous to the finding that crystals are formed by the same laws in spite of the diversity of their forms.

The process of mutation is the only known source of the raw materials of genetic variability, and hence of evolution. It is subject to experimental study, and considerable progress has been accomplished in this study in recent years. An apparent paradox has been disclosed. Although the living matter becomes adapted to its environment through formation of superior genetic patterns from mutational components, the process of mutation itself is not adaptive. On the contrary, the mutants which arise are, with rare exceptions, deleterious to their carriers, at least in the environments which the species normally encounters. Some of them are deleterious apparently in all environments. Therefore, the mutation process alone, not corrected and guided by natural selection, would result in degeneration and extinction rather than in improved adaptedness.

The ridge of the Lammer-muir hills... consists of primary micaceous schistus, and extends from St Abb's head westward... The sea-coast affords a transverse section of this alpine tract at its eastern extremity, and exhibits the change from the primary to the secondary strata... Dr HUTTON wished particularly to examine the latter of these, and on this occasion Sir JAMES HALL and I had the pleasure to accompany him. We sailed in a boat from Dunglass ... We made for a high rocky point or head-land, the SICCAR ... On landing at this point, we found that we actually trode [sic] on the primeval rock... It is here a micaceous schistus, in beds nearly vertical, highly indurated, and stretching from S.E. to N. W. The surface of this rock... has thin covering of red horizontal sandstone laid over it, ... Here, therefore, the immediate contact of the two rocks is not only visible, but is curiously dissected and laid open by the action of the waves... On us who saw these phenomena for the first time, the impression will not easily be forgotten. The palpable evidence presented to us, of one of the most extraordinary and important facts in the natural history of the earth, gave a reality and substance to those theoretical speculations, which, however probable had never till now been directly authenticated by the testimony of the senses... What clearer evidence could we have had of the different formation of these rocks, and of the long interval which separated their formation, had we actually seen them emerging from the bosom of the deep? ... The mind seemed to grow giddy by looking so far into the abyss of time; and while we listened with earnestness and admiration to the philosopher who was now unfolding to us the order and series of these wonderful events, we became sensible how much farther reason may sometimes go than imagination can venture to follow.

The successive series of stratified formations are piled on one another, almost like courses of masonry.

The words are strung together, with their own special grammar—the laws of quantum theory—to form sentences, which are molecules. Soon we have books, entire libraries, made out of molecular “sentences.” The universe is like a library in which the words are atoms. Just look at what has been written with these hundred words! Our own bodies are books in that library, specified by the organization of molecules—but the universe and literature are organizations of identical, interchangeable objects; they are information systems.

This topic brings me to that worst outcrop of the herd nature, the military system, which I abhor. That a man can take pleasure in marching in formation to the strains of a band is enough to make me despise him. He has only been given his big brain by mistake; a backbone was all he needed. This plague-spot of civilisation ought to be abolished with all possible speed. Heroism by order, senseless violence, and all the pestilent nonsense that goes by the name of patriotism–how I hate them! War seems to me a mean, contemptible thing: I would rather be hacked in pieces than take part in such an abominable business.

Those of us who were familiar with the state of inorganic chemistry in universities twenty to thirty years ago will recall that at that time it was widely regarded as a dull and uninteresting part of the undergraduate course. Usually, it was taught almost entirely in the early years of the course and then chiefly as a collection of largely unconnected facts. On the whole, students concluded that, apart from some relationships dependent upon the Periodic table, there was no system in inorganic chemistry comparable with that to be found in organic chemistry, and none of the rigour and logic which characterised physical chemistry. It was widely believed that the opportunities for research in inorganic chemistry were few, and that in any case the problems were dull and uninspiring; as a result, relatively few people specialized in the subject... So long as inorganic chemistry is regarded as, in years gone by, as consisting simply of the preparations and analysis of elements and compounds, its lack of appeal is only to be expected. The stage is now past and for the purpose of our discussion we shall define inorganic chemistry today as the integrated study of the formation, composition, structure and reactions of the chemical elements and compounds, excepting most of those of carbon.

Thus it might be said, that the vegetable is only the sketch, nor rather the ground-work of the animal; that for the formation of the latter, it has only been requisite to clothe the former with an apparatus of external organs, by which it might be connected with external objects.
From hence it follows, that the functions of the animal are of two very different classes. By the one (which is composed of an habitual succession of assimilation and excretion) it lives within itself, transforms into its proper substance the particles of other bodies, and afterwards rejects them when they are become heterogeneous to its nature. By the other, it lives externally, is the inhabitant of the world, and not as the vegetable of a spot only; it feels, it perceives, it reflects on its sensations, it moves according to their influence, and frequently is enabled to communicate by its voice its desires, and its fears, its pleasures, and its pains.
The aggregate of the functions of the first order, I shall name the organic life, because all organized beings, whether animal or vegetable, enjoy it more or less, because organic texture is the sole condition necessary to its existence. The sum of the functions of the second class, because it is exclusively the property of the animal, I shall denominate the animal life.

We cannot see how the evidence afforded by the unquestioned progressive development of organised existence—crowned as it has been by the recent creation of the earth's greatest wonder, MAN, can be set aside, or its seemingly necessary result withheld for a moment. When Mr. Lyell finds, as a witty friend lately reported that there had been found, a silver-spoon in grauwacke, or a locomotive engine in mica-schist, then, but not sooner, shall we enrol ourselves disciples of the Cyclical Theory of Geological formations.

We debase the richness of both nature and our own minds if we view the great pageant of our intellectual history as a compendium of new in formation leading from primal superstition to final exactitude. We know that the sun is hub of our little corner of the universe, and that ties of genealogy connect all living things on our planet, because these theories assemble and explain so much otherwise disparate and unrelated information–not because Galileo trained his telescope on the moons of Jupiter or because Darwin took a ride on a Galápagos tortoise.

We do not know of any enzymes or other chemical defined organic substances having specifically acting auto-catalytic properties such as to enable them to construct replicas of themselves. Neither was there a general principle known that would result in pattern-copying; if there were, the basis of life would be easier to come by. Moreover, there was no evidence to show that the enzymes were not products of hereditary determiners or genes, rather than these genes themselves, and they might even be products removed by several or many steps from the genes, just as many other known substances in the cell must be. However, the determiners or genes themselves must conduct, or at least guide, their own replication, so as to lead to the formation of genes just like themselves, in such wise that even their own mutations become .incorporated in the replicas. And this would probably take place by some kind of copying of pattern similar to that postulated by Troland for the enzymes, but requiring some distinctive chemical structure to make it possible. By virtue of this ability of theirs to replicate, these genes–or, if you prefer, genetic material–contained in the nuclear chromosomes and in whatever other portion of the cell manifests this property, such as the chloroplastids of plants, must form the basis of all the complexities of living matter that have arisen subsequent to their own appearance on the scene, in the whole course of biological evolution. That is, this genetic material must underlie all evolution based on mutation and selective multiplication.

We have here spoken of the prediction of facts of the same kind as those from which our rule was collected. But the evidence in favour of our induction is of a much higher and more forcible character when it enables us to explain and determine cases of a kind different from those which were contemplated in the formation of our hypothesis. The instances in which this has occurred, indeed, impress us with a conviction that the truth of our hypothesis is certain. No accident could give rise to such an extraordinary coincidence. No false supposition could, after being adjusted to one class of phenomena, so exactly represent a different class, when the agreement was unforeseen and contemplated. That rules springing from remote and unconnected quarters should thus leap to the same point, can only arise from that being where truth resides.

We should like to propose instead that the specificity of DNA self replication is accomplished without recourse to specific protein synthesis and that each of our complementary DNA chains serves as a template or mould for the formation onto itself of a new companion chain.
[Co-author with Francis Crick]

What clearer evidence could we have had of the different formation of these rocks, and of the long interval which separated their formation, had we actually seen them emerging from the bosom of the deep? … The mind seemed to grow giddy by looking so far into the abyss of time.

Whether moral and social phenomena are really exceptions to the general certainty and uniformity of the course of nature; and how far the methods, by which so many of the laws of the physical world have been numbered among truths irrevocably acquired and universally assented to, can be made instrumental to the gradual formation of a similar body of received doctrine in moral and political science.

Why has not anyone seen that fossils alone gave birth to a theory about the formation of the earth, that without them, no one would have ever dreamed that there were successive epochs in the formation of the globe.

With respect to Committees as you would perceive I am very jealous of their formation. I mean working committees. I think business is always better done by few than by many. I think also the working few ought not to be embarrassed by the idle many and further I think the idle many ought not to be honoured by association with the working few.—I do not think that my patience has ever come nearer to an end than when compelled to hear … long rambling malapropros enquiries of members who still have nothing in consequence to propose that shall advance the business.