Stimulus Quotes (13 quotes)
Contractile movements arise, sometimes at the instigation of external stimuli but sometimes also in the absence of any apparent external influence.
If we denote excitation as an end-effect by the sign plus (+), and inhibition as end-effect by the sign minus (–), such a reflex as the scratch-reflex can be termed a reflex of double-sign, for it develops excitatory end-effect and then inhibitory end-effect even during the duration of the exciting stimulus.
In the dog two conditions were found to produce pathological disturbances by functional interference, namely, an unusually acute clashing of the excitatory and inhibitory processes, and the influence of strong and extraordinary stimuli. In man precisely similar conditions constitute the usual causes of nervous and psychic disturbances. Different conditions productive of extreme excitation, such as intense grief or bitter insults, often lead, when the natural reactions are inhibited by the necessary restraint, to profound and prolonged loss of balance in nervous and psychic activity.
It seems to me that the view toward which we are tending is that the specificity in gene action is always a chemical specificity, probably the production of enzymes which guide metabolic processes along particular channels. A given array of genes thus determines the production of a particular kind of protoplasm with particular propertiessuch, for example, as that of responding to surface forces by the formation of a special sort of semipermeable membrane, and that of responding to trivial asymmetries in the play of external stimuli by polarization, with consequent orderly quantitative gradients in all physiologic processes. Different genes may now be called into play at different points in this simple pattern, either through the local formation of their specific substrates for action, or by activation of a mutational nature. In either case the pattern becomes more complex and qualitatively differentiated. Successive interactions of differentiated regions and the calling into play of additional genes may lead to any degree of complexity of pattern in the organism as a largely self-contained system. The array of genes, assembled in the course of evolution, must of course be one which determines a highly selfregulatory system of reactions. On this view the genes are highly specific chemically, and thus called into play only under very specific conditions; but their morphological effects, if any, rest on quantitative influences of immediate or remote products on growth gradients, which are resultants of all that has gone on before in the organism.
Just as a tree constitutes a mass arranged in a definite manner, in which, in every single part, in the leaves as in the root, in the trunk as in the blossom, cells are discovered to be the ultimate elements, so is it also with the forms of animal life. Every animal presents itself as a sum of vital unities, every one of which manifests all the characteristics of life. The characteristics and unity of life cannot be limited to anyone particular spot in a highly developed organism (for example, to the brain of man), but are to be found only in the definite, constantly recurring structure, which every individual element displays. Hence it follows that the structural composition of a body of considerable size, a so-called individual, always represents a kind of social arrangement of parts, an arrangement of a social kind, in which a number of individual existences are mutually dependent, but in such a way, that every element has its own special action, and, even though it derive its stimulus to activity from other parts, yet alone effects the actual performance of its duties.
Microbiology is usually regarded as having no relevance to the feelings and aspirations of the man of flesh and bone. Yet, never in my professional life do I find myself far removed from the man of flesh and bone. It is not only because microbes are ubiquitous in our environment, and therefore must be studied for the sake of human welfare. More interesting, and far more important in the long run, is the fact that microbes exhibit profound resemblances to man. They resemble him in their physical makeup, in their properties, in their responses to various stimuli; they also display associations with other living things which have perplexing and illuminating analogies with human societies.
Scholars should always receive with thanks new suppositions about things, provided they possess some tincture of sense; another head may often make an important discovery prompted by nothing more than such a stimulus: the generally accepted way of explaining a thing no longer had any effect on his brain and could communicate to it no new notion.
Since Pawlow [Pavlov] and his pupils have succeeded in causing the secretion of saliva in the dog by means of optic and acoustic signals, it no longer seems strange to us that what the philosopher terms an 'idea' is a process which can cause chemical changes in the body.
The Law of Inhibition. The strength of a reflex may be decreased through presentation of a second stimulus which has no other relation to the effector involved.
The stimulus of competition, when applied at an early age to real thought processes, is injurious both to nerve-power and to scientific insight.
There is, I think, no more wonderful and illuminating spectacle than that of an osmotic growth,a crude lump of brute inanimate matter germinating before our very eyes, putting forth bud and stem and root and branch and leaf and fruit, with no stimulus from germ or seed, without even the presence of organic matter. For these mineral growths are not mere crystallizations as many suppose They imitate the forms, the colour, the texture, and even the microscopical structure of organic growth so closely as to deceive the very elect.
We may, I think, draw a yet higher and deeper teaching from the phenomena of degeneration. We seem to learn from it the absolute necessity of labour and effort, of struggle and difficulty, of discomfort and pain, as the condition of all progress, whether physical or mental, and that the lower the organism the more need there is of these ever-present stimuli, not only to effect progress, but to avoid retrogression. And if so, does not this afford us the nearest attainable solution of the great problem of the origin of evil? What we call evil is the essential condition of progress in the lower stages of the development of conscious organisms, and will only cease when the mind has become so thoroughly healthy, so well balanced, and so highly organised, that the happiness derived from mental activity, moral harmony, and the social affections, will itself be a sufficient stimulus to higher progress and to the attainment of a more perfect life.
Whatever be the detail with which you cram your student, the chance of his meeting in after life exactly that detail is almost infinitesimal; and if he does meet it, he will probably have forgotten what you taught him about it. The really useful training yields a comprehension of a few general principles with a thorough grounding in the way they apply to a variety of concrete details. In subsequent practice the men will have forgotten your particular details; but they will remember by an unconscious common sense how to apply principles to immediate circumstances. Your learning is useless to you till you have lost your textbooks, burnt your lecture notes, and forgotten the minutiae which you learned by heart for the examination. What, in the way of detail, you continually require will stick in your memory as obvious facts like the sun and the moon; and what you casually require can be looked up in any work of reference. The function of a University is to enable you to shed details in favor of principles. When I speak of principles I am hardly even thinking of verbal formulations. A principle which has thoroughly soaked into you is rather a mental habit than a formal statement. It becomes the way the mind reacts to the appropriate stimulus in the form of illustrative circumstances. Nobody goes about with his knowledge clearly and consciously before him. Mental cultivation is nothing else than the satisfactory way in which the mind will function when it is poked up into activity.