[A contemporary study] predicted the loss of two-thirds of all tropical forests by the turn of the century. Hundreds of thousands of species will perish, and this reduction of 10 to 20 percent of the earth’s biota will occur in about half a human life span. … This reduction of the biological diversity of the planet is the most basic issue of our time.

[I doubt that in today's world, I and Francis Crick would ever have had our Eureka moment.] I recently went to my staircase at Clare College, Cambridge and there were women there! he said, with an enormous measure of retrospective sexual frustration. There have been a lot of convincing studies recently about the loss of productivity in the Western male. It may be that entertainment culture now is so engaging that it keeps people satisfied. We didn't have that. Science was much more fun than listening to the radio. When you are 16 or 17 and in that inherently semi-lonely period when you are deciding whether to be an intellectual, many now don't bother.
(Response when asked how he thought the climate of scientific research had changed since he made his discovery of the structure of life in 1953.)

[In] death at least there would be one profit; it would no longer be necessary to eat, to drink, to pay taxes, or to [offend] others; and as a man lies in his grave not one year, but hundreds and thousands of years, the profit was enormous. The life of man was, in short, a loss, and only his death a profit.

[My uncle said to me…] When I read, forty years ago, that shells from Syria were found in the Alps, I say, I admit, with a slightly mocking tone, that these shells were apparently brought by pilgrims who were returning from Jerusalem. M. de Buffon reprimanded me very sharply in his Theory of the Earth, page 281. I did not want to quarrel with him over shells, but I remain of the same opinion, because the impossibility that the sea formed the mountains is evident to me. Some may tell me that porphyry is made of sea urchin spikes, I’ll believe it when I see white marble is made of ostrich feathers.

[Reply to a lady enquiring: “Have we lost faith?”] Certainly not, but we have only transferred it from God to the General Medical Council.

Eine brennendste Zeitfrage allerdings! Es brennt in allen Ecken und Enden der ethnologischen Welt, brennt hell, lichterloh, in vollster Brunst, es brennt ringsum, Gross Feuer! und Niemand regt eine Hand.
A most burning question of time, though. It burns in every nook and cranny of the ethnological world, burning, bright, brightly, in the fullest blaze, and it burns all around, huge fire! and no one lifts a hand.
[Expressing his desperation over the loss of the cultural memory of ethnic traditions as so many cultures were no longer living in isolation.]

La santé est le trésor le plus précieux et le plus facile à perdre; c'est cependant le plus mal gardé.
Health is the most valuable and most easily lost treasure; yet it is the most poorly kept.

~~[Misattributed?]~~ Just remember—when you think all is lost, the future remains.

A game is on, at the other end of this infinite distance, and heads or tails will turn up. What will you wager? According to reason you cannot leave either; according to reason you cannot leave either undone... Yes, but wager you must; there is no option, you have embarked on it. So which will you have. Come. Since you must choose, let us see what concerns you least. You have two things to lose: truth and good, and two things to stake: your reason and your will, your knowledge and your happiness. And your nature has two things to shun: error and misery. Your reason does not suffer by your choosing one more than the other, for you must choose. That is one point cleared. But your happiness? Let us weigh gain and loss in calling heads that God is. Reckon these two chances: if you win, you win all; if you lose, you lose naught. Then do not hesitate, wager that He is.

A grove of giant redwoods or sequoias should be kept just as we keep a great or beautiful cathedral. The extermination of the passenger pigeon meant that mankind was just so much poorer; exactly as in the case of the destruction of the cathedral at Rheims. And to lose the chance to see frigate-birds soaring in circles above the storm, or a file of pelicans winging their way homeward across the crimson afterglow of the sunset, or a myriad terns flashing in the bright light of midday as they hover in a shifting maze above the beach—why, the loss is like the loss of a gallery of the masterpieces of the artists of old time.

A practical botanist will distinguish, at the first glance, the plant of different quarters of the globe, and yet will be at a loss to tell by what mark he detects them. There is, I know not what look—sinister, dry, obscure, in African plants; superb and elevated in the Asiatic; smooth and cheerful in the American; stunted and indurated in the Alpine.

All war is murder, robbery, trickery, and no nation ever escaped losses of men, prosperity and virility. War knows no victor.

As I stood behind the coffin of my little son the other day, with my mind bent on anything but disputation, the officiating minister read, as part of his duty, the words, 'If the dead rise not again, let us eat and drink, for to-morrow we die.' I cannot tell you how inexpressibly they shocked me. Paul had neither wife nor child, or he must have known that his alternative involved a blasphemy against all that well best and noblest in human nature. I could have laughed with scorn. What! Because I am face to face with irreparable loss, because I have given back to the source from whence it came, the cause of a great happiness, still retaining through all my life the blessings which have sprung and will spring from that cause, I am to renounce my manhood, and, howling, grovel in bestiality? Why, the very apes know better, and if you shoot their young, the poor brutes grieve their grief out and do not immediately seek distraction in a gorge.

As our cities and suburbs relentlessly expand, those priceless open spaces needed for recreation areas accessible to their people are swallowed up—often forever. Unless we preserve these spaces while they are still available, we will have none to preserve. Therefore, I shall propose new financing methods for purchasing open space and parklands now, before they are lost to us.

As soon as questions of will or decision or reason or choice of action arise, human science is at a loss.

Astronomers and physicists, dealing habitually with objects and quantities far beyond the reach of the senses, even with the aid of the most powerful aids that ingenuity has been able to devise, tend almost inevitably to fall into the ways of thinking of men dealing with objects and quantities that do not exist at all, e.g., theologians and metaphysicians. Thus their speculations tend almost inevitably to depart from the field of true science, which is that of precise observation, and to become mere soaring in the empyrean. The process works backward, too. That is to say, their reports of what they pretend actually to see are often very unreliable. It is thus no wonder that, of all men of science, they are the most given to flirting with theology. Nor is it remarkable that, in the popular belief, most astronomers end by losing their minds.

Astronomy is, not without reason, regarded, by mankind, as the sublimest of the natural sciences. Its objects so frequently visible, and therefore familiar, being always remote and inaccessible, do not lose their dignity.

Blood mixture and the result drop in the racial level is the sole cause of the dying out of old cultures; for men do not perish as a result of lost wars, but by the loss of that force of resistance which is continued only in pure blood. All who are not of good race in this world are chaff.

Books won’t stay banned. They won’t burn. Ideas won’t go to jail. In the long run of history, the censor and the inquisitor have always lost. The only sure weapon against bad ideas is better ideas. The source of better ideas is wisdom. The surest path to wisdom is a liberal education.

But as the wilderness areas are progressively exploited or “improve”, as the jeeps and bulldozers of uranium prospectors scar up the deserts and the roads are cut into the alpine timberlands, and as the remnants of the unspoiled and natural world are progressively eroded, every such loss is a little death in me. In us.

But I don’t have to know an answer. I don’t feel frightened by not knowing things, by being lost in a mysterious universe without any purpose, which is the way it really is, so far as I can tell. It doesn’t frighten me.

By the death of Mr. O. Chanute the world has lost one whose labors had to an unusual degree influenced the course of human progress. If he had not lived the entire history of progress in flying would have been other than it has been.

Charles Babbage proposed to make an automaton chess-player which should register mechanically the number of games lost and gained in consequence of every sort of move. Thus, the longer the automaton went on playing game, the more experienced it would become by the accumulation of experimental results. Such a machine precisely represents the acquirement of experience by our nervous organization.

Chemists do have a good sense of humor but lose it when they serve as referees.

Each and every loss becomes an instance of ultimate tragedy–something that once was, but shall never be known to us. The hump of the giant deer–as a nonfossilizable item of soft anatomy–should have fallen into the maw of erased history. But our ancestors provided a wondrous rescue, and we should rejoice mightily. Every new item can instruct us; every unexpected object possesses beauty for its own sake; every rescue from history’s great shredding machine is–and I don’t know how else to say this–a holy act of salvation for a bit of totality.

Economists use the expression “opportunity costs” for losses incurred through certain choices made over others, including ignorance and inaction. For systematics, or more precisely the neglect of systematics and the biological research dependent upon it, the costs are very high.

Enthusiasm for the global-warming scare also ensures that heatwaves make headlines, while contrary symptoms, such as this winter’s billion-dollar loss of Californian crops to unusual frost, are relegated to the business pages. The early arrival of migrant birds in spring provides colourful evidence for a recent warming of the northern lands. But did anyone tell you that in east Antarctica the Adélie penguins and Cape petrels are turning up at their spring nesting sites around nine days later than they did 50 years ago? While sea-ice has diminished in the Arctic since 1978, it has grown by 8% in the Southern Ocean.

Even environmentalists seem more concerned about the loss of a year or so of life expectation through cancer than they are about the degradation of the natural world by deforestation or greenhouse gases—something that could cause the death of our grandchildren.

Every gambler stakes a certainty to gain an uncertainty, and yet he stakes a finite certainty against a finite uncertainty without acting unreasonably. … The uncertainty of gain is proportioned to the certainty of the stake, according to the proportion of chances of gain and loss, and if therefore there are as many chances on one side as on the other, the game is even.

Every phenomenon, however trifling it be, has a cause, and a mind infinitely powerful, and infinitely well-informed concerning the laws of nature could have foreseen it from the beginning of the ages. If a being with such a mind existed, we could play no game of chance with him; we should always lose.

Far be it from me to suggest that geologists should be reckless in their drafts upon the bank of Time; but nothing whatever is gained, and very much is lost, by persistent niggardliness in this direction.

Force, then, is Force, but mark you! Not a thing,
Only a Vector;
Thy barbèd arrows now have lost their sting,
Impotent spectre!
Thy reign, O force! is over. Now no more
Heed we thine action;
Repulsion leaves us where we were before,
So does attraction.
Both Action and Reaction now are gone.
Just ere they vanished,
Stress joined their hands in peace, and made them one;
Then they were banished....

Fractal geometry will make you see everything differently. There is a danger in reading further. You risk the loss of your childhood vision of clouds, forests, flowers, galaxies, leaves, feathers, rocks, mountains, torrents of water, carpet, bricks, and much else besides. Never again will your interpretation of these things be quite the same.

Freudian psychoanalytical theory is a mythology that answers pretty well to Levi-Strauss's descriptions. It brings some kind of order into incoherence; it, too, hangs together, makes sense, leaves no loose ends, and is never (but never) at a loss for explanation. In a state of bewilderment it may therefore bring comfort and relief … give its subject a new and deeper understanding of his own condition and of the nature of his relationship to his fellow men. A mythical structure will be built up around him which makes sense and is believable-in, regardless of whether or not it is true.

I am reminded of the great French Marshal Lyautey, who once asked his gardener to plant a tree. The gardener objected that the tree was slow-growing and would not reach maturity for a hundred years. The Marshal replied, “In that case, there is no time to lose, plant it this afternoon.”

I ask myself whether the huge national commitment of technical talent to human spaceflight and the ever-present potential for the loss of precious human life are really justifiable.

I believe that natural history has lost much by the vague general treatment that is so common.

I feel more confident and more satisfied when I reflect that I have two professions and not one. Medicine is my lawful wife and literature is my mistress. When I get tired of one I spend the night with the other. Though it's disorderly it's not so dull, and besides, neither really loses anything, through my infidelity.

I much condole with you on your late loss... pains and diseases of the mind are only cured by Forgetfulness;-—Reason but skins the wound, which is perpetually liable to fester again.

I should feel it a grave sense of loss (as you would) if a hundred years from now Shakespeare and Newton are historical fossils in the ascent of man, in the way that Homer and Euclid are.

If it is good to teach students about the chemical industry then why is it not good to assign ethical qualities to substances along with their physical and chemical ones? We might for instance say that CS [gas] is a bad chemical because it can only ever be used by a few people with something to protect against many people with nothing to lose. Terylene or indigotin are neutral chemicals. Under capitalism their production is an exploitive process, under socialism they are used for the common good. Penicillin is a good chemical.

If we continue on our current course, the damage that has been the defining feature of my lifetime will be eclipsed by the damage coming in the next. … Science predicts that were I born today, I would be witness to the 2030s—The Amazon Rainforest, cut down until it can no longer produce enough moisture, degrades into a dry savannah, bringing catastrophic species loss—and altering the global water cycle.

If we sink to the biochemical level, then the human being has lost a great many synthetic abilities possessed by other species and, in particular, by plants and microorganisms. Our loss of ability to manufacture a variety of vitamins makes us dependent on our diet and, therefore, on the greater synthetic versatility of other creatures. This is as much a “degenerative” change as the tapeworm’s abandonment of a stomach it no longer needs, but since we are prejudiced in our own favor, we don’t mention it.

If you have built castles in the air, your work need not be lost; that is where they should be. Now put the foundations under them.

In all cases of the motion of free material points under the influence of their attractive and repulsive forces, whose intensity depends solely upon distance, the loss in tension is always equal to the gain in vis viva, and the gain in the former equal to the loss in the latter. Hence the sum of the existing tensions and vires vivae is always constant. In this most general form we can distinguish our law as the principle of the conservation of force.

In New England they once thought blackbirds useless, and mischievous to the corn. They made efforts to destroy them. The consequence was, the blackbirds were diminished; but a kind of worm, which devoured their grass, and which the blackbirds used to feed on, increased prodigiously; then, finding their loss in grass much greater than their saving in corn, they wished again for their blackbirds.

In the dog two conditions were found to produce pathological disturbances by functional interference, namely, an unusually acute clashing of the excitatory and inhibitory processes, and the influence of strong and extraordinary stimuli. In man precisely similar conditions constitute the usual causes of nervous and psychic disturbances. Different conditions productive of extreme excitation, such as intense grief or bitter insults, often lead, when the natural reactions are inhibited by the necessary restraint, to profound and prolonged loss of balance in nervous and psychic activity.

In the vestibule of the Manchester Town Hall are placed two life-sized marble statues facing each other. One of these is that of John Dalton … the other that of James Prescott Joule. … Thus honour is done to Manchester’s two greatest sons—to Dalton, the founder of modern Chemistry and of the Atomic Theory, and the laws of chemical-combining proportions; to Joule, the founder of modern Physics and the discoverer of the Law of Conservation of Energy. The one gave to the world the final and satisfactory proof … that in every kind of chemical change no loss of matter occurs; the other proved that in all the varied modes of physical change, no loss of energy takes place.

In vertebrate paleontology, increasing knowledge leads to triumphant loss of clarity.

It is impossible to imagine the universe run by a wise, just and omnipotent God, but it is quite easy to imagine it run by a board of gods. If such a board actually exists it operates precisely like the board of a corporation that is losing money.

It was not easy for a person brought up in the ways of classical thermodynamics to come around to the idea that gain of entropy eventually is nothing more nor less than loss of information.

It was noted long ago that the front row of burlesque houses was occupied predominantly by bald-headed men. In fact, such a row became known as the bald-headed row. It might be assumed from this on statistical evidence that the continued close observation of chorus girls in tights caused loss of hair from the top of the head.
[Disputing a statistical study for the American Cancer Society showing smoking to be a cancer causative.]

It’s never been more important for us to understand the effects of biodiversity loss… only if we do that, will we have any hope of averting disaster.

Knowledge and ability must be combined with ambition as well as with a sense of honesty and a severe conscience. Every analyst occasionally has doubts about the accuracy of his results, and also there are times when he knows his results to be incorrect. Sometimes a few drops of the solution were spilt, or some other slight mistake made. In these cases it requires a strong conscience to repeat the analysis and to make a rough estimate of the loss or apply a correction. Anyone not having sufficient will-power to do this is unsuited to analysis no matter how great his technical ability or knowledge. A chemist who would not take an oath guaranteeing the authenticity, as well as the accuracy of his work, should never publish his results, for if he were to do so, then the result would be detrimental not only to himself, but to the whole of science.

Let us weigh the gain and the loss in wagering that God is. Let us consider the two chances. If you gain, you gain all; if you lose, you lose nothing. Wager then without hesitation that He is.

Life through many long periods has been manifested in a countless host of varying structures, all circumscribed by one general plan, each appointed to a definite place, and limited to an appointed duration. On the whole the earth has been thus more and more covered by the associated life of plants and animals, filling all habitable space with beings capable of enjoying their own existence or ministering to the enjoyment of others; till finally, after long preparation, a being was created capable of the wonderful power of measuring and weighing all the world of matter and space which surrounds him, of treasuring up the past history of all the forms of life, and considering his own relation to the whole. When he surveys this vast and co-ordinated system, and inquires into its history and origin, can he be at a loss to decide whether it be a work of Divine thought and wisdom, or the fortunate offspring of a few atoms of matter, warmed by the anima mundi, a spark of electricity, or an accidental ray of sunshine?

Like teeth husbands are hard to get and while we have them they give us a great deal of pain and trouble. But once we lose them they leave a wide gap.

Loss of teeth and marriage spoil a woman’s beauty.

Lost in a gloom of uninspired research.

Many Species of Animals have been lost out of the World, which Philosophers and Divines are unwilling to admit, esteeming the Destruction of anyone Species a Dismembring of the Universe, and rendring the World imperfect; whereas they think the Divine Providence is especially concerned, and solicitous to secure and preserve the Works of the Creation. And truly so it is, as appears, in that it was so careful to lodge all Land Animals in the Ark at the Time of the general Deluge; and in that, of all Animals recorded in Natural Histories, we cannot say that there hath been anyone Species lost, no not of the most infirm, and most exposed to Injury and Ravine. Moreover, it is likely, that as there neither is nor can be any new Species of Animals produced, all proceeding from Seeds at first created; so Providence, without which one individual Sparrow falls not to the ground, doth in that manner watch over all that are created, that an entire Species shall not be lost or destroyed by any Accident. Now, I say, if these Bodies were sometimes the Shells and Bones of Fish, it will thence follow, that many Species have been lost out of the World... To which I have nothing to reply, but that there may be some of them remaining some where or other in the Seas, though as yet they have not come to my Knowledge. Far though they may have perished, or by some Accident been destroyed out of our Seas, yet the Race of them may be preserved and continued still in others.

More than 90 percent of the forests of western Ecuador have been destroyed during the past four decades.The loss is estimated to have extinguished or doomed over half of the species of the area’s plants and animals. Many other biologically diverse areas of the world are under similar assault.

Most loss of life and property has been due to the collapse of antiquated and unsafe structures, mostly of brick and other masonry. ... There is progress of California toward building new construction according to earthquake-resistant design. We would have less reason to ask for earthquake prediction if this was universal.

Nature proceeds little by little from things lifeless to animal life in such a way that it is impossible to determine the exact line of demarcation, nor on which side thereof an intermediate form should lie. Thus, next after lifeless things comes the plant, and of plants one will differ from another as to its amount of apparent vitality; and, in a word, the whole genus of plants, whilst it is devoid of life as compared with an animal, is endowed with life as compared with other corporeal entities. Indeed, as we just remarked, there is observed in plants a continuous scale of ascent towards the animal. So, in the sea, there are certain objects concerning which one would be at a loss to determine whether they be animal or vegetable. For instance, certain of these objects are fairly rooted, and in several cases perish if detached.

No place affords a more striking conviction of the vanity of human hopes than a publick library; for who can see the wall crouded on every side by mighty volumes, the works of laborious meditation, and accurate inquiry, now scarcely known but by the catalogue, and preserved only to encrease the pomp of learning, without considering how many hours have been wasted in vain endeavours, how often imagination has anticipated the praises of futurity, how many statues have risen to the eye of vanity, how many ideal converts have elevated zeal, how often wit has exulted in the eternal infamy of his antagonists, and dogmatism has delighted in the gradual advances of his authority, the immutability of his decrees, and the perpetuity of his power.
Non unquam dedit
Documenta fors majora, quam fragili loco
Starent superbi.
Seneca, Troades, II, 4-6
Insulting chance ne'er call'd with louder voice,
On swelling mortals to be proud no more.
Of the innumerable authors whose performances are thus treasured up in magnificent obscurity, most are forgotten, because they never deserved to be remembered, and owed the honours which they have once obtained, not to judgment or to genius, to labour or to art, but to the prejudice of faction, the stratagem of intrigue, or the servility of adulation.
Nothing is more common than to find men whose works are now totally neglected, mentioned with praises by their contemporaries, as the oracles of their age, and the legislators of science. Curiosity is naturally excited, their volumes after long enquiry are found, but seldom reward the labour of the search. Every period of time has produced these bubbles of artificial fame, which are kept up a while by the breath of fashion and then break at once and are annihilated. The learned often bewail the loss of ancient writers whose characters have survived their works; but perhaps if we could now retrieve them we should find them only the Granvilles, Montagus, Stepneys, and Sheffields of their time, and wonder by what infatuation or caprice they could be raised to notice.
It cannot, however, be denied, that many have sunk into oblivion, whom it were unjust to number with this despicable class. Various kinds of literary fame seem destined to various measures of duration. Some spread into exuberance with a very speedy growth, but soon wither and decay; some rise more slowly, but last long. Parnassus has its flowers of transient fragrance as well as its oaks of towering height, and its laurels of eternal verdure.

No Single Atom, once in Being, lost,…

Nothing is lost and nothing is created in the operations of art as those of nature.

On the 1st of August, 1774, I endeavoured to extract air from mercurius calcinates per se [mercury oxide]; and I presently found that, by means of this lens, air was expelled from it very readily. … I admitted water to it [the extracted air], and found that it was not imbibed by it. But what surprized me more than I can well express, was, that a candle burned in this air with a remarkably vigorous flame… I was utterly at a loss how to account for it.

On the basis of the results recorded in this review, it can be claimed that the average sand grain has taken many hundreds of millions of years to lose 10 per cent. of its weight by abrasion and become subangular. It is a platitude to point to the slowness of geological processes. But much depends on the way things are put. For it can also be said that a sand grain travelling on the bottom of a river loses 10 million molecules each time it rolls over on its side and that representation impresses us with the high rate of this loss. The properties of quartz have led to the concentration of its grains on the continents, where they could now form a layer averaging several hundred metres thick. But to my mind the most astounding numerical estimate that follows from the present evaluations, is that during each and every second of the incredibly long geological past the number of quartz grains on earth has increased by 1,000 million.

One of the most disturbing ways that climate change is already playing out is through what ecologists call “mismatch” or “mistiming.” This is the process whereby warming causes animals to fall out of step with a critical food source, particularly at breeding times, when a failure to find enough food can lead to rapid population losses.

One tragic example of the loss of forests and then water is found in Ethiopia. The amount of its forested land has decreased from 40 to 1 percent in the last four decades. Concurrently, the amount of rainfall has declined to the point where the country is rapidly becoming a wasteland.

Revolutions of ages do not oft recover the loss of a rejected truth, for the want of which whole nations fare the worse.

Science Fiction, SF, is related to the mainstream of writing much as ghost stories were related to it in the past. Possibly tales of the supernatural were a by-product of a waning religious faith and possibly SF is a by-product of our increasing loss of faith in science.

Science has but one fashion—to lose nothing once gained.

Second Law
All the acquisitions or losses wrought by nature on individuals, through the influence of the environment in which their race has long been placed, and hence through the influence of the predominant use or permanent disuse of any organ; all these are preserved by reproduction to the new individuals which arise, provided that the acquired modifications are common to both sexes, or at least to the individuals which produce the young.

Seldom, if ever, was any knowledge given to keep but to impart; the grace of this rich jewel is lost in concealment.

Some few, & I am one, even wish to God, though at the loss of millions of lives, that the North would proclaim a crusade against Slavery. In the long run, a million horrid deaths would be amply repaid in the cause of humanity. ... Great God how I sh^d like to see that greatest curse on Earth Slavery abolished.

Statistics are far from being the barren array of figures ingeniously and laboriously combined into columns and tables, which many persons are apt to suppose them. They constitute rather the ledger of a nation, in which, like the merchant in his books, the citizen can read, at one view, all of the results of a year or of a period of years, as compared with other periods, and deduce the profit or the loss which has been made, in morals, education, wealth or power.

Suppose it were perfectly certain that the life and fortune of every one of us would, one day or other, depend upon his winning or losing a game of chess. Don't you think that we should all consider it to be a primary duty to learn at least the names and the moves of the pieces; to have a notion of a gambit, and a keen eye for all the means of giving and getting out of check? Do you not think that we should look with a disapprobation amounting to scorn upon the father who allowed his son, or the state which allowed its members, to grow up without knowing a pawn from a knight?
Yet, it is a very plain and elementary truth that the life, the fortune, and the happiness of every one of us, and, more or less, of those who are connected with us, do depend upon our knowing something of the rules of a game infinitely more difficult and complicated than chess. It is a game which has been played for untold ages, every man and woman of us being one of the two players in a game of his or her own. The chess-board is the world, the pieces are the phenomena of the universe, the rules of the game are what we call the laws of nature. The player on the other side is hidden from us. We know that his play is always fair, just, and patient. But also we know, to our cost, that he never overlooks a mistake, or makes the smallest allowance for ignorance. To the man who plays well the highest stakes are paid with that sort of overflowing generosity with which the strong shows delight in strength. And one who plays ill is checkmated—without haste, but without remorse.

The best class of scientific mind is the same as the best class of business mind. The great desideratum in either case is to know how much evidence is enough to warrant action. It is as unbusiness-like to want too much evidence before buying or selling as to be content with too little. The same kind of qualities are wanted in either case. The difference is that if the business man makes a mistake, he commonly has to suffer for it, whereas it is rarely that scientific blundering, so long as it is confined to theory, entails loss on the blunderer. On the contrary it very often brings him fame, money and a pension. Hence the business man, if he is a good one, will take greater care not to overdo or underdo things than the scientific man can reasonably be expected to take.

The coastal zone may be the single most important portion of our planet. The loss of its biodiversity may have repercussions far beyond our worst fears.

The extraordinary development of modern science may be her undoing. Specialism, now a necessity, has fragmented the specialities themselves in a way that makes the outlook hazardous. The workers lose all sense of proportion in a maze of minutiae.

The fairest thing we can experience is the mysterious. It is the fundamental emotion which stands at the cradle of true science. He who knows it not, and can no longer wonder, no longer feel amazement, is as good as dead. We all had this priceless talent when we were young. But as time goes by, many of us lose it. The true scientist never loses the faculty of amazement. It is the essence of his being.

The gentleman [Mr. Taber] from New York says [agricultural research] is all foolish. Yes; it was foolish when Burbank was experimenting with wild cactus. It was foolish when the Wright boys went down to Kitty Hawk and had a contraption there that they were going to fly like birds. It was foolish when Robert Fulton tried to put a boiler into a sail boat and steam it up the Hudson. It was foolish when one of my ancestors thought the world was round and discovered this country so that the gentleman from New York could become a Congressman. (Laughter.) ... Do not seek to stop progress; do not seek to put the hand of politics on these scientific men who are doing a great work. As the gentleman from Texas points out, it is not the discharge of these particular employees that is at stake, it is all the work of investigation, of research, of experimentation that has been going on for years that will be stopped and lost.

The gold rush in Madre de Dios, Peru, exceeds the combined effects of all other causes of forest loss in the region, including from logging, ranching and agriculture. This is really important because we’re talking about a global biodiversity hotspot. The region’s incredible flora and fauna is being lost to gold fever.

The losses of the natural world are our loss, their silence silences something within the human mind. Human language is lit with animal life: we play cats-cradle or have hare-brained ideas; we speak of badgering, or outfoxing someone; to squirrel something away and to ferret it out. … When our experience of the wild world shrinks, we no longer fathom the depths of our own words; language loses its lustre and vividness.

The maladies that affect the clerks aforesaid arise from three causes. First, constant sitting, secondly, the incessant movement of the the hand and always in the same direction, thirdly, the strain on the mind from the effort not to disfigure the books by errors or cause loss to their employers when they add, subtract, or do other sums in arithmetic. The diseases brought about by sitting constantly are easily understood; they are obstructions of the viscera, e.g. the liver and spleen, indigestion in the stomach, numbness of the legs, a considerable hindrance in the circulation of the blood, and an unhealthy habit.

The Mathematics, I say, which effectually exercises, not vainly deludes or vexatiously torments studious Minds with obscure Subtilties, perplexed Difficulties, or contentious Disquisitions; which overcomes without Opposition, triumphs without Pomp, compels without Force, and rules absolutely without Loss of Liberty; which does not privately over-reach a weak Faith, but openly assaults an armed Reason, obtains a total Victory, and puts on inevitable Chains; whose Words are so many Oracles, and Works as many Miracles; which blabs out nothing rashly, nor designs anything from the Purpose, but plainly demonstrates and readily performs all Things within its Verge; which obtrudes no false Shadow of Science, but the very Science itself, the Mind firmly adhering to it, as soon as possessed of it, and can never after desert it of its own Accord, or be deprived of it by any Force of others: Lastly the Mathematics, which depends upon Principles clear to the Mind, and agreeable to Experience; which draws certain Conclusions, instructs by profitable Rules, unfolds pleasant Questions; and produces wonderful Effects; which is the fruitful Parent of, I had almost said all, Arts, the unshaken Foundation of Sciences, and the plentiful Fountain of Advantage to human Affairs.

The most disgraceful cause of the scarcity [of remedies] is that even those who know them do not want to point them out, as if they were going to lose what they pass on to others.

The next difficulty is in the economical production of small lights by electricity. This is what is commonly meant by the phrase, ‘dividing the electric light.’ Up to the present time, and including Mr. Edison’s latest experiments, it appears that this involves an immense loss of efficiency. Next comes the difficulty of distributing on any large scale the immense electric currents which would be needed.

The noble science of Geology loses glory from the extreme imperfection of the record. The crust of the earth with its embedded remains must not be looked at as a well-filled museum, but as a poor collection made at hazard and at rare intervals.

The opinion I formed from attentive observation of the facts and phenomena, is as follows. When ice, for example, or any other solid substance, is changing into a fluid by heat, I am of opinion that it receives a much greater quantity of heat than that what is perceptible in it immediately after by the thermometer. A great quantity of heat enters into it, on this occasion, without making it apparently warmer, when tried by that instrument. This heat, however, must be thrown into it, in order to give it the form of a fluid; and I affirm, that this great addition of heat is the principal, and most immediate cause of the fluidity induced. And, on the other hand, when we deprive such a body of its fluidity again, by a diminution of its heat, a very great quantity of heat comes out of it, while it is assuming a solid form, the loss of which heat is not to be perceived by the common manner of using the thermometer. The apparent heat of the body, as measured by that instrument, is not diminished, or not in proportion to the loss of heat which the body actually gives out on this occasion; and it appears from a number of facts, that the state of solidity cannot be induced without the abstraction of this great quantity of heat. And this confirms the opinion, that this quantity of heat, absorbed, and, as it were, concealed in the composition of fluids, is the most necessary and immediate cause of their fluidity.

The outlook seems grim. Natural selection under civilized conditions may lead mankind to evolve towards a state of genetic overspecialization for living in gadget-ridden environments. It is certainly up to man to decide whether this direction of his evolution is or is not desirable. If it is not, man has, or soon will have, the knowledge requisite to redirect the evolution of his species pretty much as he sees fit. Perhaps we should not be too dogmatic about this choice of direction. We may be awfully soft compared to paleolithic men when it comes to struggling, unaided by gadgets, with climatic difficulties and wild beasts. Most of us feel most of the time that this is not a very great loss. If our remote descendants grow to be even more effete than we are, they may conceivably be compensated by acquiring genotypes conducive to kindlier dispositions and greater intellectual capacities than those prevalent in mankind today.
[Co-author with American statistician Gordon Allen.]

The price we pay for our advance in civilization is a loss of happiness through the heightening of the sense of guilt.

The real problem is not the loss of a particular species but the loss of particular kinds of environments. … When you lose a big, dramatic species like the whooping crane, you don’t notice that you are also losing other plants and animals. … We are only putting Band-Aids on until we recognize we need to be protecting environments, not just endangered species.

The reduced variability of small populations is not always due to accidental gene loss, but sometimes to the fact that the entire population was started by a single pair or by a single fertilized female. These “founders” of the population carried with them only a very small proportion of the variability of the parent population. This “founder” principle sometimes explains even the uniformity of rather large populations, particularly if they are well isolated and near the borders of the range of the species.

The rule for life in the sea can be summed up in the well known expression “big fish eat little fish”. … Research shows that great losses occur in the fish cycle because small fish are eaten by larger ones, and in many cases the larger fish are not fit for human consumption.

The sun has lost no beams, the earth no elements ; gravity is as adhesive, heat as expansive, light as joyful, air as virtuous, water as medicinal as on the first day. There is no loss, only transference. When the heat is less here it is not lost, but more heat is there.

The vacuum-apparatus requires that its manipulators constantly handle considerable amounts of mercury. Mercury is a strong poison, particularly dangerous because of its liquid form and noticeable volatility even at room temperature. Its poisonous character has been rather lost sight of during the present generation. My co-workers and myself found from personal experience-confirmed on many sides when published—that protracted stay in an atmosphere charged with only 1/100 of the amount of mercury required for its saturation, sufficed to induce chronic mercury poisoning. This first reveals itself as an affection of the nerves, causing headaches, numbness, mental lassitude, depression, and loss of memory; such are very disturbing to one engaged in intellectual occupations.

The world's forests need to be seen for what they are—giant global utilities, providing essential public services to humanity on a vast scale. They store carbon, which is lost to the atmosphere when they burn, increasing global warming. The life they support cleans the atmosphere of pollutants and feeds it with moisture. They act as a natural thermostat, helping to regulate our climate and sustain the lives of 1.4 billion of the poorest people on this Earth. And they do these things to a degree that is all but impossible to imagine.

The worst thing that will probably happen—in fact is already well underway—is not energy depletion, economic collapse, conventional war, or the expansion of totalitarian governments. As terrible as these catastrophes would be for us, they can be repaired in a few generations. The one process now going on that will take millions of years to correct is loss of genetic and species diversity by the destruction of natural habitats. This is the folly our descendants are least likely to forgive us.

There is more evidence to prove that saltiness [of the sea] is due to the admixture of some substance ... It is this stuff which makes salt water heavy (it weighs more than fresh water) and thick. The difference in consistency is such that ships with the same cargo very nearly sink in a river when they are quite fit to navigate in the sea. This circumstance has before now caused loss to shippers freighting their ships in a river. That the thicker consistency is due to an admixture of something is proved by the fact that if you make strong brine by the admixture of salt, eggs, even when they are full, float in it. It almost becomes like mud; such a quantity of earthy matter is there in the sea.
[Aristotle recognised the different density of fresh (river) or salty (sea) water. He describes an experiment using an egg (which sinks in fresh water) that floats in a strong brine solution.]

There were taken apples, and … closed up in wax. … After a month's space, the apple inclosed in was was as green and fresh as the first putting in, and the kernals continued white. The cause is, for that all exclusion of open air, which is ever predatory, maintaineth the body in its first freshness and moisture.
[In the U.S., since the 1920s, (to replace the fruit's original wax coating that is lost in the cleaning process after harvesting), natural waxes, such as carnauba wax, are applied in an extremely thin coating, to reduce loss of moisture and maintain crispness and appearance.]

This is the question
Marry
Children—(if it Please God)—Constant companion (& friend in old age) who will feel interested in one—object to be beloved and played with—better than a dog anyhow. Home, & someone to take care of house—Charms of music and female chit-chat.—These things good for one’s health.—but terrible loss of time.—
My God, it is Intolerable to think of spending ones whole life, like a neuter bee, working, working—& nothing after all.—No, no, won’t do. Imagine living all one’s day solitary in smoky dirty London House.—Only picture to yourself a nice soft wife on a sofa with good fire, & books & music perhaps-—Compare this vision with the dingy reality of Grt. Marlbro’ Street.
Not Marry
Freedom to go where one liked—choice of Society and little of it. —Conversation of clever men at clubs—Not forced to visit relatives, & to bend in every trifle. —to have the expense and anxiety of children—perhaps quarreling—Loss of time. —cannot read in the Evenings—fatness & idleness—Anxiety & responsibility—less money for books &c—if many children forced to gain one’s bread. —(but then it is very bad for ones health to work too much)
Perhaps my wife won’t like London; then the sentence is banishment & degradation into indolent, idle fool.
Marry—Marry—Marry Q.E.D.
It being proved necessary to Marry When? Soon or late?

Throughout the last four hundred years, during which the growth of science had gradually shown men how to acquire knowledge of the ways of nature and mastery over natural forces, the clergy have fought a losing battle against science, in astronomy and geology, in anatomy and physiology, in biology and psychology and sociology. Ousted from one position, they have taken up another. After being worsted in astronomy, they did their best to prevent the rise of geology; they fought against Darwin in biology, and at the present time they fight against scientific theories of psychology and education. At each stage, they try to make the public forget their earlier obscurantism, in order that their present obscurantism may not be recognized for what it is.

To most people, I fancy, the stars are beautiful; but if you asked why, they would be at a loss to reply, until they remembered what they had heard about astronomy, and the great size and distance and possible habitation of those orbs. ... [We] persuade ourselves that the power of the starry heavens lies in the suggestion of astronomical facts.

To take one of the simplest cases of the dissipation of energy, the conduction of heat through a solid—consider a bar of metal warmer at one end than the other and left to itself. To avoid all needless complication, of taking loss or gain of heat into account, imagine the bar to be varnished with a substance impermeable to heat. For the sake of definiteness, imagine the bar to be first given with one half of it at one uniform temperature, and the other half of it at another uniform temperature. Instantly a diffusing of heat commences, and the distribution of temperature becomes continuously less and less unequal, tending to perfect uniformity, but never in any finite time attaining perfectly to this ultimate condition. This process of diffusion could be perfectly prevented by an army of Maxwell’s ‘intelligent demons’* stationed at the surface, or interface as we may call it with Prof. James Thomson, separating the hot from the cold part of the bar.
* The definition of a ‘demon’, according to the use of this word by Maxwell, is an intelligent being endowed with free will, and fine enough tactile and perceptive organisation to give him the faculty of observing and influencing individual molecules of matter.

Two kinds of symbol must surely be distinguished. The algebraic symbol comes naked into the world of mathematics and is clothed with value by its masters. A poetic symbol—like the Rose, for Love, in Guillaume de Lorris—comes trailing clouds of glory from the real world, clouds whose shape and colour largely determine and explain its poetic use. In an equation, x and y will do as well as a and b; but the Romance of the Rose could not, without loss, be re-written as the Romance of the Onion, and if a man did not see why, we could only send him back to the real world to study roses, onions, and love, all of them still untouched by poetry, still raw.

We are all dietetic sinners; only a small percent of what we eat nourishes us, the balance goes to waste and loss of energy .

We have not the reverent feeling for the rainbow that a savage has, because we know how it is made. We have lost as much as we gained by prying into that matter.

What happened to those Ice Age beasts? What caused the mammoth and mastodon and wooly rhinoceros to pay the ultimate Darwinian penalty, while bison and musk ox survived? Why didn't the fauna of Africa suffer the kinds of losses evident in other regions of the world? And if something like climatic change caused the extinction of North America's Pleistocene horse, how have feral horses managed to reestablish themselves on the western range?

What we call recycling is typically the product losing its quality. Paper gets mixed with other papers, re-chlorinated and contaminated with toxic inks. The fiber length gets shorter…and you end up with gray, fuzzy stuff that doesn't really work for you. That's downcycling. Michael Braungart and I coined the term upcycling, meaning that the product could actually get better as it comes through the system.

Whatever may have been imputed to some other studies under the notion of insignificancy and loss of time, yet these [mathematics], I believe, never caused repentance in any, except it was for their remissness in the prosecution of them.

When I received the Nobel Prize, the only big lump sum of money I have ever seen, I had to do something with it. The easiest way to drop this hot potato was to invest it, to buy shares. I knew that World War II was coming and I was afraid that if I had shares which rise in case of war, I would wish for war. So I asked my agent to buy shares which go down in the event of war. This he did. I lost my money and saved my soul.

When the war finally came to an end, 1 was at a loss as to what to do. ... I took stock of my qualifications. A not-very-good degree, redeemed somewhat by my achievements at the Admiralty. A knowledge of certain restricted parts of magnetism and hydrodynamics, neither of them subjects for which I felt the least bit of enthusiasm.
No published papers at all … [Only gradually did I realize that this lack of qualification could be an advantage. By the time most scientists have reached age thirty they are trapped by their own expertise. They have invested so much effort in one particular field that it is often extremely difficult, at that time in their careers, to make a radical change. I, on the other hand, knew nothing, except for a basic training in somewhat old-fashioned physics and mathematics and an ability to turn my hand to new things. … Since I essentially knew nothing, I had an almost completely free choice. …

When we seek a textbook case for the proper operation of science, the correction of certain error offers far more promise than the establishment of probable truth. Confirmed hunches, of course, are more upbeat than discredited hypotheses. Since the worst traditions of ‘popular’ writing falsely equate instruction with sweetness and light, our promotional literature abounds with insipid tales in the heroic mode, although tough stories of disappointment and loss give deeper insight into a methodology that the celebrated philosopher Karl Popper once labeled as ‘conjecture and refutation.’

With advancing years new impressions do not enter so rapidly, nor are they so hospitably received… There is a gradual diminution of the opportunities for age to acquire fresh knowledge. A tree grows old not by loss of the vitality of the cambium, but by the gradual increase of the wood, the non-vital tissue, which so easily falls a prey to decay.

X-rays ... I am afraid of them. I stopped experimenting with them two years ago, when I came near to losing my eyesight and Dally, my assistant practically lost the use of both of his arms.