[In 18th-century Britain] engineers for the most began as simple workmen, skilful and ambitious but usually illiterate and self-taught. They were either millwrights like Bramah, mechanics like Murdoch and George Stephenson, or smiths like Newcomen and Maudslay.

A garden requires patient labor and attention. Plants do not grow merely to satisfy ambitions or to fulfill good intentions. They thrive because some one expended effort on them.

A man’s first duty, a young man’s at any rate, is to be ambitious … the noblest ambition is that of leaving behind one something of permanent value.

Archimedes possessed so high a spirit, so profound a soul, and such treasures of highly scientific knowledge, that though these inventions [used to defend Syracuse against the Romans] had now obtained him the renown of more than human sagacity, he yet would not deign to leave behind him any commentary or writing on such subjects; but, repudiating as sordid and ignoble the whole trade of engineering, and every sort of art that lends itself to mere use and profit, he placed his whole affection and ambition in those purer speculations where there can be no reference to the vulgar needs of life; studies, the superiority of which to all others is unquestioned, and in which the only doubt can be whether the beauty and grandeur of the subjects examined, or the precision and cogency of the methods and means of proof, most deserve our admiration.

Character cannot be developed in ease and quiet. Only through experience of trial and suffering can the soul be strengthened, ambition inspired, and success achieved.

Florey was not an easy personality. His drive and ambition were manifest from the day he arrived ... He could be ruthless and selfish; on the other hand, he could show kindliness, a warm humanity and, at times, sentiment and a sense of humour. He displayed utter integrity and he was scathing of humbug and pretence. His attitude was always—&ldqo;You must take me as you find me” But to cope with him at times, you had to do battle, raise your voice as high as his and never let him shout you down. You had to raise your pitch to his but if you insisted on your right he was always, in the end, very fair. I must say that at times, he went out of his way to cut people down to size with some very destructive criticism. But I must also say in the years I knew him he did not once utter a word of praise about himself.

Further, it will not be amiss to distinguish the three kinds and, as it were, grades of ambition in mankind. The first is of those who desire to extend their own power in their native country, a vulgar and degenerate kind. The second is of those who labor to extend the power and dominion of their country among men. This certainly has more dignity, though not less covetousness. But if a man endeavor to establish and extend the power and dominion of the human race itself over the universe, his ambition (if ambition it can be called) is without doubt both a more wholesome and a more noble thing than the other two. Now the empire of man over things depends wholly on the arts and sciences. For we cannot command nature except by obeying her.

Happy the men who made the first essay,
And to celestial regions found the way!
No earthly vices clogg’d their purer souls,
That they could soar so high as touch the poles:
Sublime their thoughts and from pollution clear,
Bacchus and Venus held no revels there;
From vain ambition free; no love of war
Possess’d their minds, nor wranglings at the bar;
No glaring grandeur captivates their eyes,
For such see greater glory in the skies:
Thus these to heaven attain.

His mother’s favorite, he [Freud] possessed the self-confidence that told him he would achieve something worth while in life, and the ambition to do so, though for long the direction this would take remained uncertain.

How vast those Orbs must be, and how inconsiderable this Earth, the Theatre upon which all our mighty Designs, all our Navigations, and all our Wars are transacted, is when compared to them. A very fit consideration, and matter of Reflection, for those Kings and Princes who sacrifice the Lives of so many People, only to flatter their Ambition in being Masters of some pitiful corner of this small Spot.

I entered Gettysburg College intent on preparing for medical school. But my ambition was far from resolute. Every new subject that I encountered in college proved a siren song. I imagined myself an historian, a philosopher, a novelist, rarely a scientist.

I had the ambition to not only go farther than man had gone before, but to go as far as it was possible to go.

I have no desire to write my own biography, as long as I have strength and means to do better work.

I have not chosen a career that will lead me to a great fortune, but not my principal ambition.
In fact, later in life he enjoyed comfortable income from his science discoveries.

I sought excitement and, taking chances, I was all ready to fail in order to achieve something large.

I uphold my own rights, and therefore I also recognize the rights of others. This is the principle I act upon in life, in politics and in science. We owe it to ourselves to defend our rights, for it is the only guarantee for our individual development, and for our influence upon the community at large. Such a defence is no act of vain ambition, and it involves no renunciation of purely scientific aims. For, if we would serve science, we must extend her limits, not only as far as our own knowledge is concerned, but in the estimation of others.

I was a reasonably good student in college ... My chief interests were scientific. When I entered college, I was devoted to out-of-doors natural history, and my ambition was to be a scientific man of the Audubon, or Wilson, or Baird, or Coues type—a man like Hart Merriam, or Frank Chapman, or Hornaday, to-day.

I was roused by the amphetamine of ambition.

If intellectual curiosity, professional pride, and ambition are the dominant incentives to research, then assuredly no one has a fairer chance of gratifying them than a mathematician.

In order to understand what is meant by the word “brain” as it is used by neuroscientists, we must bear in mind the evidence that this organ contains in some recorded form the basis of one’s whole conscious life. It contains the record of all our aims and ambitions and is essential for the experience of all pleasures and pains, all loves and hates.

In physiology, as in all other sciences, no discovery is useless, no curiosity misplaced or too ambitious, and we may be certain that every advance achieved in the quest of pure knowledge will sooner or later play its part in the service of man.

In the temple of science are many mansions, and various indeed are they that dwell therein and the motives that have led them thither. Many take to science out of a joyful sense of superior intellectual power; science is their own special sport to which they look for vivid experience and the satisfaction of ambition; many others are to be found in the temple who have offered the products of their brains on this altar for purely utilitarian purposes. Were an angel of the Lord to come and drive all the people belonging to these two categories out of the temple, the assemblage would be seriously depleted, but there would still be some men, of both present and past times, left inside. Our Planck is one of them, and that is why we love him.

John Dalton was a very singular Man, a quaker by profession & practice: He has none of the manners or ways of the world. A tolerable mathematician He gained his livelihood I believe by teaching the mathematics to young people. He pursued science always with mathematical views. He seemed little attentive to the labours of men except when they countenanced or confirmed his own ideas... He was a very disinterested man, seemed to have no ambition beyond that of being thought a good Philosopher. He was a very coarse Experimenter & almost always found the results he required.—Memory & observation were subordinate qualities in his mind. He followed with ardour analogies & inductions & however his claims to originality may admit of question I have no doubt that he was one of the most original philosophers of his time & one of the most ingenious.

Keep away from people who try to belittle your ambitions. Small people always do that, but the really great make you feel that you, too, can become great.

Knowledge and ability must be combined with ambition as well as with a sense of honesty and a severe conscience. Every analyst occasionally has doubts about the accuracy of his results, and also there are times when he knows his results to be incorrect. Sometimes a few drops of the solution were spilt, or some other slight mistake made. In these cases it requires a strong conscience to repeat the analysis and to make a rough estimate of the loss or apply a correction. Anyone not having sufficient will-power to do this is unsuited to analysis no matter how great his technical ability or knowledge. A chemist who would not take an oath guaranteeing the authenticity, as well as the accuracy of his work, should never publish his results, for if he were to do so, then the result would be detrimental not only to himself, but to the whole of science.

Let us see how high we can fly before the sun melts the wax in our wings.
About the ambitious pursuit of knowledge, alluding to Icarus of the Greek myth.

Love is of all stimulants the most powerful. It sharpens the wits like danger, and the memory like hatred; it spurs the will like ambition; it exalts the imagination like hashish; it intoxicates like wine.

Most people would succeed in small things, if they were not troubled with great ambitions.

My ambition was to bring to bear on medicine a chemical approach. I did that by chemical manipulation of viruses and chemical ways of thinking in biomedical research.

Our ambition should be to rule ourselves, the true kingdom for each one of us; and true progress is to know more, and be more, and to do more.

Our problems lie not in the genes of the common man but in the ambitions of those with power.

Science in England is not a profession: its cultivators are scarcely recognised even as a class. Our language itself contains no single term by which their occupation can be expressed. We borrow a foreign word [Savant] from another country whose high ambition it is to advance science, and whose deeper policy, in accord with more generous feelings, gives to the intellectual labourer reward and honour, in return for services which crown the nation with imperishable renown, and ultimately enrich the human race.

The Astonishing Hypothesis is that “You,” your joys and your sorrows, your memories and your ambitions, your sense of identity and free will, are in fact no more than the behaviour of a vast assembly of nerve cells and their associated molecules. As Lewis Carroll’s Alice might have phrased it: “You’re nothing but a pack of neurons.”

The brown and charred rags that hung from the sides of it, I presently recognized as the decaying vestiges of books. They had long since dropped to pieces, and every semblance of print had left them. … Had I been a literary man I might, perhaps, have moralized upon the futility of all ambition.

The Commonwealth of Learning is not at this time without Master-Builders, whose mighty Designs, in advancing the Sciences, will leave lasting Monuments to the Admiration of Posterity; But every one must not hope to be a Boyle, or a Sydenham; and in an Age that produces such Masters, as the Great-Huygenius, and the incomparable Mr. Newton, with some other of that Strain; 'tis Ambition enough to be employed as an Under-Labourer in clearing Ground a little, and removing some of the Rubbish, that lies in the way to Knowledge.

The cult of individual personalities is always, in my view, unjustified. To be sure, nature distributes her gifts variously among her children. But there are plenty of the well-endowed ones too, thank God, and I am firmly convinced that most of them live quiet, unregarded lives. It strikes me as unfair, and even in bad taste, to select a few of them for boundless admiration, attributing superhuman powers of mind and character to them. This has been my fate, and the contrast between the popular estimate of my powers and achievements and the reality is simply grotesque. The consciousness of this extraordinary state of affairs would be unbearable but for one great consoling thought: it is a welcome symptom in an age which is commonly denounced as materialistic, that it makes heroes of men whose ambitions lie wholly in the intellectual and moral sphere. This proves that knowledge and justice are ranked above wealth and power by a large section of the human race. My experience teaches me that this idealistic outlook is particularly prevalent in America, which is usually decried as a particularly materialistic country.

The different branches of Arithmetic—Ambition, Distraction, Uglification, and Derision.

The history of science alone can keep the physicist from the mad ambitions of dogmatism as well as the despair of pyrrhonian scepticism.

The opening of a foreign trade, by making them acquainted with new objects, or tempting them by the easier acquisition of things which they had not previously thought attainable, sometimes works a sort of industrial revolution in a country whose resources were previously undeveloped for want of energy and ambition in the people; inducing those who were satisfied with scanty comforts and little work to work harder for the gratification of their new tastes, and even to save, and accumulate capital, for the still more complete satisfaction of those tastes at a future time.

The requirement for great success is great ambition ... for triumph over other men, not merely over nature.

The universe is not required to be in perfect harmony with human ambition.

Theories cannot claim to be indestructible. They are only the plough which the ploughman uses to draw his furrow and which he has every right to discard for another one, of improved design, after the harvest. To be this ploughman, to see my labours result in the furtherance of scientific progress, was the height of my ambition, and now the Swedish Academy of Sciences has come, at this harvest, to add the most brilliant of crowns.

To me there never has been a higher source of honour or distinction than that connected with advances in science. I have not possessed enough of the eagle in my character to make a direct flight to the loftiest altitudes in the social world; and I certainly never endeavored to reach those heights by using the creeping powers of the reptile, who in ascending, generally chooses the dirtiest path, because it is the easiest.

Two contrary laws seem to be wrestling with each other nowadays: the one, a law of blood and of death, ever imagining new means of destruction and forcing nations to be constantly ready for the battlefield—the other, a law of peace, work and health, ever evolving new means for delivering man from he scourges which beset him. The one seeks violent conquests, the other the relief of humanity. The latter places one human life above any victory: while the former would sacrifice hundreds and thousands of lives to the ambition of one.

We seem ambitious God's whole work to undo.
...With new diseases on ourselves we war,
And with new physic, a worse engine far.

While religion prescribes brotherly love in the relations among the individuals and groups, the actual spectacle more resembles a battlefield than an orchestra. Everywhere, in economic as well as in political life, the guiding principle is one of ruthless striving for success at the expense of one’s fellow men. This competitive spirit prevails even in school and, destroying all feelings of human fraternity and cooperation, conceives of achievement not as derived from the love for productive and thoughtful work, but as springing from personal ambition and fear of rejection.