Macbeth: How does your patient, doctor?
Doctor: Not so sick, my lord,
As she is troubled with thick-coming fancies,
That keep her from her rest.
Macbeth: Cure her of that.
Canst thou not minister to a mind diseased,
Pluck from the memory a rooted sorrow,
Raze out the written troubles of the brain,
And with some sweet oblivious antidote
Cleanse the stuffed bosom of that perilous stuff
Which weighs upon the heart?
Doctor: Therein the patient
Must minister to himself.
Macbeth: Throw physic to the dogs; I'll none of it.

A man who is master of himself can end a sorrow as easily as he can invent a pleasure.

All cell biologists are condemned to suffer an incurable secret sorrow: the size of the objects of their passion. … But those of us enamored of the cell must resign ourselves to the perverse, lonely fascination of a human being for things invisible to the naked human eye.

And men ought to know that from nothing else but thence [from the brain] come joys, delights, laughter and sports, and sorrows, griefs, despondency, and lamentations. And by this, in an especial manner, we acquire wisdom and knowledge, and see and hear, and know what are foul and hat are fair, what are bad and what are good, what are sweet, and what unsavory... And by the same organ we become mad and delirious, and fears and terrors assail us... All these things we endure from the brain, when it is not healthy... In these ways I am of the opinion that the brain exercises the greatest power in the man. This is the interpreter to us of those things which emanate from the air, when it [the brain] happens to be in a sound state.

Feeling weightless… it’s so many things together. A feeling of pride, of healthy solitude, of dignified freedom from everything that’s dirty, sticky. You feel exquisitely comfortable . . . and you feel you have so much energy, such an urge to do things, such an ability to do things. And you work well, yes, you think well, without sweat, without difficulty as if the biblical curse in the sweat of thy face and in sorrow no longer exists, As if you’ve been born again.

For in much wisdom is much grief and he that increaseth knowledge, increaseth sorrow.

I have had three personal ideals. One, to do the day’s work well and not to bother about tomorrow.… The second ideal has been to act the Golden Rule, as far as in me lay, towards my professional brethren and towards the patients committed to my care. And the third has been to cultivate such a measure of equanimity as would enable me to bear success with humility, the affection of my friends without pride, and to be ready when the day of sorrow and grief came to meet it with the courage befitting a man.

If at this moment I am not a worn-out, debauched, useless carcass of a man, if it has been or will be my fate to advance the cause of science, if I feel that I have a shadow of a claim on the love of those about me, if in the supreme moment when I looked down into my boy’s grave my sorrow was full of submission and without bitterness, it is because these agencies have worked upon me, and not because I have ever cared whether my poor personality shall remain distinct forever from the All from whence it came and whither it goes.
And thus, my dear Kingsley, you will understand what my position is. I may be quite wrong, and in that case I know I shall have to pay the penalty for being wrong. But I can only say with Luther, “Gott helfe mir, ich kann nichts anders [God help me, I cannot do otherwise].”

In the moonlight
While drinking homemade wine
My sorrow hung heavy
And my heart felt like lead.
The moon was golden yellow
The night soft and mellow.
There was a smell of jasmine
All around.
And I felt the weight of the world
Upon my shoulders.
I looked at the twinkling stars in the sky
So far and wide
Here’s to you
I lifted my wine
And my eyes looked upon the brilliance
Of the moon and stars
From afar...

Into each life some rain must fall,
Some days must be dark and dreary.

Men ought to know that from the brain, and from the brain only, arise our pleasures, joys, laughter and jests, as well as our sorrows, pains, griefs and tears. Through it, in particular, we think, see, hear, and distinguish the ugly from the beautiful, the bad from the good, the pleasant from the unpleasant, in some cases using custom as a test, in others perceiving them from their utility. It is the same thing which makes us mad or delirious, inspires us with dread or fear, whether by night or by day, brings sleeplessness, inopportune mistakes, aimless anxieties, absent-mindedness, and acts that are contrary to habit. These things that we suffer all come from the brain, when it is not healthy, but becomes abnormally hot, cold, moist, or dry, or suffers any other unnatural affection to which it was not accustomed. Madness comes from its moistness.

Much science, much sorrow.

Nothing will sustain you more potently than the power to recognize in your humdrum routine, as perhaps it may be thought, the true poetry of life—the poetry of the commonplace, of the ordinary man, of the plain, toil-worn woman, with their loves and their joys, their sorrows and their griefs.

Positive, objective knowledge is public property. It can be transmitted directly from one person to another, it can be pooled, and it can be passed on from one generation to the next. Consequently, knowledge accumulates through the ages, each generation adding its contribution. Values are quite different. By values, I mean the standards by which we judge the significance of life. The meaning of good and evil, of joy and sorrow, of beauty, justice, success-all these are purely private convictions, and they constitute our store of wisdom. They are peculiar to the individual, and no methods exist by which universal agreement can be obtained. Therefore, wisdom cannot be readily transmitted from person to person, and there is no great accumulation through the ages. Each man starts from scratch and acquires his own wisdom from his own experience. About all that can be done in the way of communication is to expose others to vicarious experience in the hope of a favorable response.

Science tries to answer the question: ‘How?’ How do cells act in the body? How do you design an airplane that will fly faster than sound? How is a molecule of insulin constructed? Religion, by contrast, tries to answer the question: ‘Why?’ Why was man created? Why ought I to tell the truth? Why must there be sorrow or pain or death? Science attempts to analyze how things and people and animals behave; it has no concern whether this behavior is good or bad, is purposeful or not. But religion is precisely the quest for such answers: whether an act is right or wrong, good or bad, and why.

Standing now in diffused light, with the wind at my back, I experience suddenly a feeling of completeness–not a feeling of having achieved something or of being stronger than everyone who was ever here before, not a feeling of having arrived at the ultimate point, not a feeling of supremacy. Just a breath of happiness deep inside my mind and my breast. The summit seemed suddenly to me to be a refuge, and I had not expected to find any refuge up here. Looking at the steep, sharp ridges below us, I have the impression that to have come later would have been too late. Everything we now say to one another, we only say out of embarrassment. I don’t think anymore. As I pull the tape recorder, trancelike, from my rucksack, and switch it on wanting to record a few appropriate phrases, tears again well into my eyes. “Now we are on the summit of Everest,” I begin, “it is so cold that we cannot take photographs…” I cannot go on, I am immediately shaken with sobs. I can neither talk nor think, feeling only how this momentous experience changes everything. To reach only a few meters below the summit would have required the same amount of effort, the same anxiety and burden of sorrow, but a feeling like this, an eruption of feeling, is only possible on the summit itself.

The Astonishing Hypothesis is that “You,” your joys and your sorrows, your memories and your ambitions, your sense of identity and free will, are in fact no more than the behaviour of a vast assembly of nerve cells and their associated molecules. As Lewis Carroll’s Alice might have phrased it: “You’re nothing but a pack of neurons.”

The desire for guidance, love, and support prompts men to form the social or moral conception of God. This is the God of Providence, who protects, disposes, rewards, and punishes; the God who, according to the limits of the believer’s outlook, loves and cherishes the life of the tribe or of the human race, or even or life itself; the comforter in sorrow and unsatisfied longing; he who preserves the souls of the dead. This is the social or moral conception of God.

The first pressure of sorrow crushes out from our hearts the best wine; afterwards the constant weight of it brings forth bitterness, — the taste and stain from the lees of the vat.

There are some arts which to those that possess them are painful, but to those that use them are helpful, a common good to laymen, but to those that practise them grievous. Of such arts there is one which the Greeks call medicine. For the medical man sees terrible sights, touches unpleasant things, and the misfortunes of others bring a harvest of sorrows that are peculiarly his; but the sick by means of the art rid themselves of the worst of evils, disease, suffering, pain and death.

We spend our years as a tale that is told, but the tale varies in a hundred different ways, varies between man and man, between year and year, between youth and age, sorrow and joy, laughter and tears. How different the story of the child’s year from the man’s; how much longer it seems; how far apart seem the vacations, and the Christmases, and the New Years! But let the child become a man, and he will find that he can tell full fast enough these stories of a year; that if he is disposed to make good use of them he has no hours to wish away; the plot develops very rapidly, and the conclusion gallops on the very heels of that first chapter which records the birth of a new year.