... all the great scientists have one thing in common: each snatched from the subtle motions of nature one irrevocable secret; each caught one feather of the plumage of the Great White Bird that symbolizes everlasting truth.

... If I let myself believe anything on insufficient evidence, there may be no great harm done by the mere belief; it may be true after all, or I may never have occasion to exhibit it in outward acts. But I cannot help doing this great wrong towards Man, that I make myself credulous. The danger to society is not merely that it should believe wrong things, though that is great enough; but that it should become credulous, and lose the habit of testing things and inquiring into them; for then it must sink back into savagery.

... in time of war, soldiers, however sensible, care a great deal more on some occasions about slaking their thirst than about the danger of enteric fever.
[Better known as typhoid, the disease is often spread by drinking contaminated water.]

… it may happen that small differences in the initial conditions produce very great ones in the final phenomena.

… man-midwifery, with other “indecencies,” is a great system of fashionable prostitution; a primary school of infamy—as the fashionable hotel and parlor wine glass qualify candidates for the two-penny grog-shop and the gutter.

… on these expanded membranes [butterfly wings] Nature writes, as on a tablet, the story of the modifications of species, so truly do all changes of the organisation register themselves thereon. Moreover, the same colour-patterns of the wings generally show, with great regularity, the degrees of blood-relationship of the species. As the laws of nature must be the same for all beings, the conclusions furnished by this group of insects must be applicable to the whole world.

… the reasoning process [employed in mathematics] is not different from that of any other branch of knowledge, … but there is required, and in a great degree, that attention of mind which is in some part necessary for the acquisition of all knowledge, and in this branch is indispensably necessary. This must be given in its fullest intensity; … the other elements especially characteristic of a mathematical mind are quickness in perceiving logical sequence, love of order, methodical arrangement and harmony, distinctness of conception.

… the truth is that the knowledge of external nature and of the sciences which that knowledge requires or includes, is not the great or the frequent business of the human mind. Whether we provide for action or conversation, whether we wish to be useful or pleasing, the first requisite is the religious and moral knowledge of right and wrong; the next is an acquaintance with the history of mankind, and with those examples which may be said to embody truth, and prove by events the reasonableness of opinions. Prudence and justice are virtues, and excellencies, of all times and of all places; we are perpetually moralists, but we are geometricians only by chance. Our intercourse with intellectual nature is necessary; our speculations upon matter are voluntary, and at leisure. Physical knowledge is of such rare emergence, that one man may know another half his life without being able to estimate his skill in hydrostatics or astronomy; but his moral and prudential character immediately appears.

... we ought to have saints' days to commemorate the great discoveries which have been made for all mankind, and perhaps for all time—or for whatever time may be left to us. Nature ... is a prodigal of pain. I should like to find a day when we can take a holiday, a day of jubilation when we can fête good Saint Anaesthesia and chaste and pure Saint Antiseptic. ... I should be bound to celebrate, among others, Saint Penicillin...

...a man estimable for his learning, amiable for his life, and venerable for his piety. Arbuthnot was a man of great comprehension, skilful in his profession, versed in the sciences, acquainted with ancient literature, and able to animate his mass of knowledge by a bright and active imagination; a scholar with great brilliance of wit; a wit who, in the crowd of life, retained and discovered a noble ardour of religious zeal.

...great difficulties are felt at first and these cannot be overcome except by starting from experiments .. and then be conceiving certain hypotheses ... But even so, very much hard work remains to be done and one needs not only great perspicacity but often a degree of good fortune.

...He cannot conclude however, without observing, that from the contemplation of so great a variety of extraneous fossils discovered in the cliffs which were evidently the produce of very different climates, he thinks himself rationally induced to believe that nothing short of an universal deluge could be a cause adequate to this effect.

…I distinguish two parts of it, which I call respectively the brighter and the darker. The brighter seems to surround and pervade the whole hemisphere; but the darker part, like a sort of cloud, discolours the Moon’s surface and makes it appear covered with spots. Now these spots, as they are somewhat dark and of considerable size, are plain to everyone and every age has seen them, wherefore I will call them great or ancient spots, to distinguish them from other spots, smaller in size, but so thickly scattered that they sprinkle the whole surface of the Moon, but especially the brighter portion of it. These spots have never been observed by anyone before me; and from my observations of them, often repeated, I have been led to the opinion which I have expressed, namely, that I feel sure that the surface of the Moon is not perfectly smooth, free from inequalities and exactly spherical… but that, on the contrary, it is full of inequalities, uneven, full of hollows and protuberances, just like the surface of the Earth itself, which is varied everywhere by lofty mountains and deep valleys.

…The present revolution of scientific thought follows in natural sequence on the great revolutions at earlier epochs in the history of science. Einstein’s special theory of relativity, which explains the indeterminateness of the frame of space and time, crowns the work of Copernicus who first led us to give up our insistence on a geocentric outlook on nature; Einstein's general theory of relativity, which reveals the curvature or non-Euclidean geometry of space and time, carries forward the rudimentary thought of those earlier astronomers who first contemplated the possibility that their existence lay on something which was not flat. These earlier revolutions are still a source of perplexity in childhood, which we soon outgrow; and a time will come when Einstein’s amazing revelations have likewise sunk into the commonplaces of educated thought.

...the source of all great mathematics is the special case, the concrete example. It is frequent in mathematics that every instance of a concept of seemingly generality is, in essence, the same as a small and concrete special case.

“But in the binary system,” Dale points out, handing back the squeezable glass, “the alternative to one isn’t minus one, it’s zero. That’s the beauty of it, mechanically.” “O.K. Gotcha. You’re asking me, What’s this minus one? I’ll tell you. It’s a plus one moving backward in time. This is all in the space-time foam, inside the Planck duration, don’t forget. The dust of points gives birth to time, and time gives birth to the dust of points. Elegant, huh? It has to be. It’s blind chance, plus pure math. They’re proving it, every day. Astronomy, particle physics, it’s all coming together. Relax into it, young fella. It feels great. Space-time foam.”

“Normal” science, in Kuhn’s sense, exists. It is the activity of the non-revolutionary, or more precisely, the not-too-critical professional: of the science student who accepts the ruling dogma of the day… in my view the 'normal' scientist, as Kuhn describes him, is a person one ought to be sorry for… He has been taught in a dogmatic spirit: he is a victim of indoctrination… I can only say that I see a very great danger in it and in the possibility of its becoming normal… a danger to science and, indeed, to our civilization. And this shows why I regard Kuhn’s emphasis on the existence of this kind of science as so important.

“On earth there is nothing great but man; and in man there is nothing great but mind.”
A favorite quote by Phavorinus which Hamilton used as a motto posted in his classroom.

“She can't do sums a bit!” the Queens said together, with great emphasis.
“Can you do sums?” Alice said, turning suddenly on the White Queen, for she didn't like being found fault with so much.
The Queen gasped and shut her eyes. “I can do Addition, if you give me time-but I can do Subtraction, under any circumstances!”

“These changes in the body,” he wrote in the review paper he sent to the American Journal of Physiology late in 1913, “are, each one of them, directly serviceable in making the organism more efficient in the struggle which fear or rage or pain may involve; for fear and rage are organic preparations for action, and pain is the most powerful known stimulus to supreme exertion. The organism which with the aid of increased adrenal secretion can best muster its energies, can best call forth sugar to supply the labouring muscles, can best lessen fatigue, and can best send blood to the parts essential in the run or the fight for life, is most likely to survive. Such, according to the view here propounded, is the function of the adrenal medulla at times of great emergency.”

[1665-04-30] ...Great fear of the sicknesses here in the City, it being said that two or three houses are already shut up. God preserve us all.

[1665-06-10] ...In the evening home to supper, and there to my great trouble hear that the plague is come into the City (though it hath these three or four weeks since its beginning been wholly out of the City); but where it begin but in my good friend and neighbour's, Dr Burnett in Fanchurch Street - which in both points troubles me mightily. To the office to finish my letters, and then home to bed, being troubled at the sickness ... and particularly how to put my things and estate in order, in case it should please God to call me away.

[1665-08-16] ...Hence to the Exchange, which I have not been a great while. But Lord, how sad a sight it is to see the streets empty of people, and very few upon the Change - jealous of every door that one sees shut up, lest it should be the plague - and about us, two shops in three, if not more, generally shut up. ... It was dark before I could get home; and so land at church-yard stairs, where to my great trouble I met a dead Corps, of the plague, in the narrow ally, just bringing down a little pair of stairs - but I thank God I was not much disturbed at it. However, I shall beware of being late abroad again.

[1665-08-31] Up, and after putting several things in order to my removal to Woolwich, the plague having a great increase this week beyond all expectation, of almost 2000 - making the general Bill 7000, odd 100 and the plague above 6000 .... Thus this month ends, with great sadness upon the public through the greateness of the plague, everywhere through the Kingdom almost. Every day sadder and sadder news of its increase. In the City died this week 7496; and all of them, 6102 of the plague. But it is feared that the true number of the dead this week is near 10000 - partly from the poor that cannot be taken notice of through the greatness of the number, and partly from the Quakers and others that will not have any bell ring for them. As to myself, I am very well; only, in fear of the plague, and as much of an Ague, by being forced to go early and late to Woolwich, and my family to lie there continually.

[1665-09-14] ...my finding that although the Bill [total of dead] in general is abated, yet the City within the walls is encreasd and likely to continue so (and is close to our house there) - my meeting dead corps's of the plague, carried to be buried close to me at noonday through the City in Fanchurch-street - to see a person sick of the sores carried close by me by Grace-church in a hackney-coach - my finding the Angell tavern at the lower end of Tower-hill shut up; and more then that, the alehouse at the Tower-stairs; and more then that, that the person was then dying of the plague when I was last there, a little while ago at night, to write a short letter there, and I overheard the mistress of the house sadly saying to her husband somebody was very ill, but did not think it was of the plague - to hear that poor Payne my waterman hath buried a child and is dying himself - to hear that a labourer I sent but the other day to Dagenhams to know how they did there is dead of the plague and that one of my own watermen, that carried me daily, fell sick as soon as he had landed me on Friday morning last, when I had been all night upon the water ... is now dead of the plague - to hear ... that Mr Sidny Mountagu is sick of a desperate fever at my Lady Carteret's at Scott's hall - to hear that Mr. Lewes hath another daughter sick - and lastly, that both my servants, W Hewers and Tom Edwards, have lost their fathers, both in St. Sepulcher's parish, of the plague this week - doth put me into great apprehensions of melancholy, and with good reason. But I put off the thoughts of sadness as much as I can, and the rather to keep my wife in good heart and family also.

[1665-10-16] But Lord, how empty the streets are, and melancholy, so many poor sick people in the streets, full of sores, and so many sad stories overheard as I walk, everybody talking of this dead, and that man sick, and so many in this place, and so many in that. And they tell me that in Westminster there is never a physitian, and but one apothecary left, all being dead - but that there are great hopes of a great decrease this week. God send it.

[1665-11-22] I heard this day that the plague is come very low; that is 600 and odd - and great hopes of a further decrease, because of this day's being a very exceeding hard frost - and continues freezing. ...

[1665-12-31] Thus ends this year ... It is true we have gone through great melancholy because of the great plague, and I put to great charges by it, by keeping my family long at Woolwich, and myself and another part of my family, my clerks, at my charge at Greenwich ... But now the plague is abated almost to nothing ... But many of such as I know very well, dead. Yet to our great joy, the town fills apace, and shops begin to open again. Pray God continue the plague's decrease - for that keeps the Court away from the place of business, and so all goes to wrack as to public matters, they at this distance not thinking of it.

[About mathematicians’ writings] Extreme external elegance, sometimes a somewhat weak skeleton of conclusions characterizes the French; the English, above all Maxwell, are distinguished by the greatest dramatic bulk.

[About the great synthesis of atomic physics in the 1920s:] It was a heroic time. It was not the doing of any one man; it involved the collaboration of scores of scientists from many different lands. But from the first to last the deeply creative, subtle and critical spirit of Niels Bohr guided, restrained, deepened and finally transmuted the enterprise.

[Alexander the Great] was often extremely brutal to his captives, whom he sold into slavery, tortured to death, or forced to learn Greek.

[At the end of the story, its main character, Tom] is now a great man of science, and can plan railroads, and steam-engines, and electric telegraphs, and rifled guns, and so forth; and knows everything about everything, except why a hen's egg don't turn into a crocodile, and two or three other little things that no one will know till the coming of the Cocqcigrues.

[Boundless curiosity.] That’s what being alive is about. I mean, it’s the fun of it all, making sense of it, understanding it. There’s a great pleasure in knowing why trees shed their leaves in winter. Everybody knows they do, but why? If you lose that, then you’ve lost pleasure.

[Davy's] March of Glory, which he has run for the last six weeks—within which time by the aid and application of his own great discovery, of the identity of electricity and chemical attractions, he has placed all the elements and all their inanimate combinations in the power of man; having decomposed both the Alkalies, and three of the Earths, discovered as the base of the Alkalies a new metal... Davy supposes there is only one power in the world of the senses; which in particles acts as chemical attractions, in specific masses as electricity, & on matter in general, as planetary Gravitation... when this has been proved, it will then only remain to resolve this into some Law of vital Intellect—and all human knowledge will be Science and Metaphysics the only Science.
In November 1807 Davy gave his famous Second Bakerian Lecture at the Royal Society, in which he used Voltaic batteries to “decompose, isolate and name” several new chemical elements, notably sodium and potassium.

[De Morgan relates that some person had made up 800 anagrams on his name, of which he had seen about 650. Commenting on these he says:]
Two of these I have joined in the title-page:
[Ut agendo surgamus arguendo gustamus.]
A few of the others are personal remarks.
Great gun! do us a sum!
is a sneer at my pursuit; but,
Go! great sum! [integral of a to the power u to the power n with respect to u] is more dignified. …
Adsum, nugator, suge!
is addressed to a student who continues talking after the lecture has commenced: …
Graduatus sum! nego
applies to one who declined to subscribe for an M.A. degree.

[Decimal currency is desirable because] by that means all calculations of interest, exchange, insurance, and the like are rendered much more simple and accurate, and, of course, more within the power of the great mass of people. Whenever such things require much labor, time, and reflection, the greater number who do not know, are made the dupes of the lesser number who do.

[Dubious attribution] We are all continually faced with great opportunities which are brilliantly disguised as unsolvable problems.

[Engineering] is a great profession. There is the fascination of watching a figment of the imagination emerge through the aid of science to a plan on paper. Then it moves to realization in stone or metal or energy. Then it brings homes to men or women. Then it elevates the standards of living and adds to the comforts of life. That is the engineer’s high privilege.

[Euclid's Elements] has been for nearly twenty-two centuries the encouragement and guide of that scientific thought which is one thing with the progress of man from a worse to a better state. The encouragement; for it contained a body of knowledge that was really known and could be relied on, and that moreover was growing in extent and application. For even at the time this book was written—shortly after the foundation of the Alexandrian Museum—Mathematics was no longer the merely ideal science of the Platonic school, but had started on her career of conquest over the whole world of Phenomena. The guide; for the aim of every scientific student of every subject was to bring his knowledge of that subject into a form as perfect as that which geometry had attained. Far up on the great mountain of Truth, which all the sciences hope to scale, the foremost of that sacred sisterhood was seen, beckoning for the rest to follow her. And hence she was called, in the dialect of the Pythagoreans, ‘the purifier of the reasonable soul.’

[Florence Nightingale] was a great administrator, and to reach excellence here is impossible without being an ardent student of statistics. Florence Nightingale has been rightly termed the “Passionate Statistician.” Her statistics were more than a study, they were indeed her religion. For her, Quetelet was the hero as scientist, and the presentation copy of his Physique Sociale is annotated by her on every page. Florence Nightingale believed—and in all the actions of her life acted upon that belief—that the administrator could only be successful if he were guided by statistical knowledge. The legislator—to say nothing of the politician—too often failed for want of this knowledge. Nay, she went further: she held that the universe—including human communities—was evolving in accordance with a divine plan; that it was man's business to endeavour to understand this plan and guide his actions in sympathy with it. But to understand God's thoughts, she held we must study statistics, for these are the measure of his purpose. Thus the study of statistics was for her a religious duty.

[For] men to whom nothing seems great but reason ... nature ... is a cosmos, so admirable, that to penetrate to its ways seems to them the only thing that makes life worth living. These are the men whom we see possessed by a passion to learn ... Those are the natural scientific men; and they are the only men that have any real success in scientific research.

[Freud's] great strength, though sometimes also his weakness, was the quite extraordinary respect he had for the singular fact... When he got hold of a simple but significant fact he would feel, and know, that it was an example of something general or universal, and the idea of collecting statistics on the matter was quite alien to him.

[Geology] may be looked upon as the history of the earth’s changes during preparation for the reception of organized beings, a history, which has all the character of a great epic.

[Great scientists] are men of bold ideas, but highly critical of their own ideas: they try to find whether their ideas are right by trying first to find whether they are not perhaps wrong. They work with bold conjectures and severe attempts at refuting their own conjectures.

[Heisenberg's seminal 1925 paper initiating quantum mechanics marked] one of the great jumps—perhaps the greatest—in the development of twentieth century physics.

[Herbert Spencer] has discovered a great law of evolution in nature, which underlies all phenomena, & which is as important & more comprehensive than Newton’s law of gravitation.

[I have a great] distaste for controversy…. I have often seen it do great harm, and yet remember few cases in natural knowledge where it has helped much either to pull down error or advance truth. Criticism, on the other hand, is of much value.

[If I were to be reincarnated] I would come back as a sloth. Hanging from a tree, chewing leaves sounds great.

[In early mill designs, from repeated handling, the flour was mixed with a] great quantity of dirt … from the dirty feet of every one who trampled in it, trailing it over the whole Mill and wasting much … [for] people did not even then like to eat dirt, if they could see it.

[In mathematics] we behold the conscious logical activity of the human mind in its purest and most perfect form. Here we learn to realize the laborious nature of the process, the great care with which it must proceed, the accuracy which is necessary to determine the exact extent of the general propositions arrived at, the difficulty of forming and comprehending abstract concepts; but here we learn also to place confidence in the certainty, scope and fruitfulness of such intellectual activity.

[It] is not the nature of things for any one man to make a sudden, violent discovery; science goes step by step and every man depends on the work of his predecessors. When you hear of a sudden unexpected discovery—a bolt from the blue—you can always be sure that it has grown up by the influence of one man or another, and it is the mutual influence which makes the enormous possibility of scientific advance. Scientists are not dependent on the ideas of a single man, but on the combined wisdom of thousands of men, all thinking of the same problem and each doing his little bit to add to the great structure of knowledge which is gradually being erected.

[L]et us not overlook the further great fact, that not only does science underlie sculpture, painting, music, poetry, but that science is itself poetic. The current opinion that science and poetry are opposed is a delusion. … On the contrary science opens up realms of poetry where to the unscientific all is a blank. Those engaged in scientific researches constantly show us that they realize not less vividly, but more vividly, than others, the poetry of their subjects. Whoever will dip into Hugh Miller’s works on geology, or read Mr. Lewes's “Seaside Studies,” will perceive that science excites poetry rather than extinguishes it. And whoever will contemplate the life of Goethe will see that the poet and the man of science can co-exist in equal activity. Is it not, indeed, an absurd and almost a sacrilegious belief that the more a man studies Nature the less he reveres it? Think you that a drop of water, which to the vulgar eye is but a drop of water, loses anything in the eye of the physicist who knows that its elements are held together by a force which, if suddenly liberated, would produce a flash of lightning? Think you that what is carelessly looked upon by the uninitiated as a mere snow-flake, does not suggest higher associations to one who has seen through a microscope the wondrously varied and elegant forms of snow-crystals? Think you that the rounded rock marked with parallel scratches calls up as much poetry in an ignorant mind as in the mind of a geologist, who knows that over this rock a glacier slid a million years ago? The truth is, that those who have never entered upon scientific pursuits know not a tithe of the poetry by which they are surrounded. Whoever has not in youth collected plants and insects, knows not half the halo of interest which lanes and hedge-rows can assume. Whoever has not sought for fossils, has little idea of the poetical associations that surround the places where imbedded treasures were found. Whoever at the seaside has not had a microscope and aquarium, has yet to learn what the highest pleasures of the seaside are. Sad, indeed, is it to see how men occupy themselves with trivialities, and are indifferent to the grandest phenomena—care not to understand the architecture of the Heavens, but are deeply interested in some contemptible controversy about the intrigues of Mary Queen of Scots!—are learnedly critical over a Greek ode, and pass by without a glance that grand epic written by the finger of God upon the strata of the Earth!

[Mathematics] is security. Certainty. Truth. Beauty. Insight. Structure. Architecture. I see mathematics, the part of human knowledge that I call mathematics, as one thing—one great, glorious thing. Whether it is differential topology, or functional analysis, or homological algebra, it is all one thing. … They are intimately interconnected, they are all facets of the same thing. That interconnection, that architecture, is secure truth and is beauty. That’s what mathematics is to me.

[On the 11th day of November 1572], in the evening, after sunset, when, according to my habit, I was contemplating the stars in a clear sky, I noticed that a new and unusual star, surpassing all others in brilliancy, was shining almost directly over my head; and since I had, almost from boyhood, known all the stars of the heavens perfectly (there is no great difficulty in gaining that knowledge), it was quite evident to me that there had never before been any star in that place in the sky, even the smallest, to say nothing of a star so conspicuously bright as this. I was so astonished at this sight that I was not ashamed to doubt the trustworthiness of my own eyes. But when I observed that others, too, on having the place pointed out to them, could see that there was a star there, I had no further doubts. A miracle indeed, either the greatest of all that have occurred in the whole range of nature since the beginning of the world, or one certainly that is to be classed with those attested by the Holy Oracles.

[Other than fossils,] the most important of these other records of creation is, without doubt, ontogeny, that is, the history of the developmment of the organic individual (embryology and motamorphology). It briefly repeats in great and marked features the series of forms which the ancestors of the respective individuals have passed through from the beginning of their tribe. We have designated the palaeontological history of the development of the ancestors of a living form as the history of a tribe, or phylogeny, and we may therefore thus enunciate this exceedingly important biogenetic fundamental principle: “Ontogeny is a short and quick repetition, or recapitulation, of Phylogeny, determined by the laws of Inheritance and Adaptation.”

[Radium emits electrons with a velocity so great that] one gram is enough to lift the whole of the British fleet to the top of Ben Nevis; and I am not quite certain that we could not throw in the French fleet as well.

[Referring to Fourier’s mathematical theory of the conduction of heat] … Fourier's great mathematical poem…

[T]he small is great, the great is small; all is in equilibrium in necessity...

[The body of law] has taxed the deliberative spirit of ages. The great minds of the earth have done it homage. It was the fruit of experience. Under it men prospered, all the arts flourished, and society stood firm. Every right and duty could be understood because the rules regulating each had their foundation in reason, in the nature and fitness of things; were adapted to the wants of our race, were addressed to the mind and to the heart; were like so many scraps of logic articulate with demonstration. Legislation, it is true occasionally lent its aid, but not in the pride of opinion, not by devising schemes inexpedient and untried, but in a deferential spirit, as a subordinate co-worker.

[The famous attack of Sir William Hamilton on the tendency of mathematical studies] affords the most express evidence of those fatal lacunae in the circle of his knowledge, which unfitted him for taking a comprehensive or even an accurate view of the processes of the human mind in the establishment of truth. If there is any pre-requisite which all must see to be indispensable in one who attempts to give laws to the human intellect, it is a thorough acquaintance with the modes by which human intellect has proceeded, in the case where, by universal acknowledgment, grounded on subsequent direct verification, it has succeeded in ascertaining the greatest number of important and recondite truths. This requisite Sir W. Hamilton had not, in any tolerable degree, fulfilled. Even of pure mathematics he apparently knew little but the rudiments. Of mathematics as applied to investigating the laws of physical nature; of the mode in which the properties of number, extension, and figure, are made instrumental to the ascertainment of truths other than arithmetical or geometrical—it is too much to say that he had even a superficial knowledge: there is not a line in his works which shows him to have had any knowledge at all.

[The steamboat] will answer for sea voyages as well as for inland navigation, in particular for packets, where there may be a great number of passengers. He is also of opinion, that fuel for a short voyage would not exceed the weight of water for a long one, and it would produce a constant supply of fresh water. ... [T]he boat would make head against the most violent tempests, and thereby escape the danger of a lee shore; and that the same force may be applied to a pump to free a leaky ship of her water. ... [T]he good effects of the machine, is the almost omnipotent force by which it is actuated, and the very simple, easy, and natural way by which the screws or paddles are turned to answer the purpose of oars.
[This letter was written in 1785, before the first steamboat carried a man (Fitch) on 27 Aug 1787.]

[The teaching of Nature] is harsh and wasteful in its operation. Ignorance is visited as sharply as wilful disobedience—incapacity meets with the same punishment as crime. Nature’s discipline is not even a word and a blow, and the blow first; but the blow without the word. It is left to you to find out why your ears are boxed.
The object of what we commonly call education—that education in which man intervenes, and which I shall distinguish as artificial education—is to make good these defects in Nature’s methods; to prepare the child to receive Nature’s education, neither incapably, nor ignorantly, nor with wilful disobedience; and to understand the preliminary symptoms of her displeasure, without waiting for the box on the ear. In short, all artificial education ought to he an anticipation of natural education. And a liberal education is an artificial education, which has not only prepared a man to escape the great evils of disobedience to natural laws, but has trained him to appreciate and to seize upon the rewards, which Nature scatters with as free a hand as her penalties.

[The toughest part of being in charge is] killing ideas that are great but poorly timed. And delivering tough feedback that’s difficult to hear but that I know will help people—and the team—in the long term.

[The] great fairy Science, who is likely to be queen of all the fairies for many a year to come, can only do you good, and never do you harm…

[There was] in some of the intellectual leaders a great aspiration to demonstrate that the universe ran like a piece of clock-work, but this was was itself initially a religious aspiration. It was felt that there would be something defective in Creation itself—something not quite worthy of God—unless the whole system of the universe could be shown to be interlocking, so that it carried the pattern of reasonableness and orderliness. Kepler, inaugurating the scientist’s quest for a mechanistic universe in the seventeenth century, is significant here—his mysticism, his music of the spheres, his rational deity demand a system which has the beauty of a piece of mathematics.

[There] are cases where there is no dishonesty involved but where people are tricked into false results by a lack of understanding about what human beings can do to themselves in the way of being led astray by subjective effects, wishful thinking or threshold interactions. These are examples of pathological science. These are things that attracted a great deal of attention. Usually hundreds of papers have been published upon them. Sometimes they have lasted for fifteen or twenty years and then they gradually die away.
[Coining the term “pathological science” for the self-deceiving application of science to a phenomenon that doesn't exist.]

[Thomas Jefferson] played a major role in one of the great tragedies of recent World history, a tragedy which he so elegantly mourned: the dispossession and decimation of the first Americans.

[Watching natural history programs] brings a solace you can’t describe in words. It’s because we’re part of it fundamentally…. In moments of great grief, that’s where you look and immerse yourself. You realise you are not immortal, you are not a god, you are part of the natural world and you come to accept that.

[We need not think] that there is any Contradiction, when Philosophy teaches that to be done by Nature; which Religion, and the Sacred Scriptures, teach us to be done by God: no more, than to say, That the balance of a Watch is moved by the next Wheel, is to deny that Wheel, and the rest, to be moved by the Spring; and that both the Spring, and all the other Parts, are caused to move together by the Maker of them. So God may be truly the Cause of This Effect, although a Thousand other Causes should be supposed to intervene: For all Nature is as one Great Engine, made by, and held in His Hand.

[William Rushton was] a man with great personal magnetism and considerable charm… [although] There were those who misjudged all of this as arrogance.

[Young] was afterwards accustomed to say, that at no period of his life was he particularly fond of repeating experiments, or even of very frequently attempting to originate new ones; considering that, however necessary to the advancement of science, they demanded a great sacrifice of time, and that when the fact was once established, that time was better employed in considering the purposes to which it might be applied, or the principles which it might tend to elucidate.

“The Universe repeats itself, with the possible exception of history.” Of all earthly studies history is the only one that does not repeat itself. ... Astronomy repeats itself; botany repeats itself; trigonometry repeats itself; mechanics repeats itself; compound long division repeats itself. Every sum if worked out in the same way at any time will bring out the same answer. ... A great many moderns say that history is a science; if so it occupies a solitary and splendid elevation among the sciences; it is the only science the conclusions of which are always wrong.

The Mighty Task is Done

At last the mighty task is done;
Resplendent in the western sun
The Bridge looms mountain high;
Its titan piers grip ocean floor,
Its great steel arms link shore with shore,
Its towers pierce the sky.

On its broad decks in rightful pride,
The world in swift parade shall ride,
Throughout all time to be;
Beneath, fleet ships from every port,
Vast landlocked bay, historic fort,
And dwarfing all the sea.

To north, the Redwood Empires gates;
To south, a happy playground waits,
In Rapturous appeal;
Here nature, free since time began,
Yields to the restless moods of man,
Accepts his bonds of steel.

Launched midst a thousand hopes and fears,
Damned by a thousand hostile sneers,
Yet Neer its course was stayed,
But ask of those who met the foe
Who stood alone when faith was low,
Ask them the price they paid.

Ask of the steel, each strut and wire,
Ask of the searching, purging fire,
That marked their natal hour;
Ask of the mind, the hand, the heart,
Ask of each single, stalwart part,
What gave it force and power.

An Honored cause and nobly fought
And that which they so bravely wrought,
Now glorifies their deed,
No selfish urge shall stain its life,
Nor envy, greed, intrigue, nor strife,
Nor false, ignoble creed.

High overhead its lights shall gleam,
Far, far below lifes restless stream,
Unceasingly shall flow;
For this was spun its lithe fine form,
To fear not war, nor time, nor storm,
For Fate had meant it so.

[As Chief Scientific Adviser to the British Ministry of Defence] We persist in regarding ourselves as a Great Power, capable of everything and only temporarily handicapped by economic difficulties. We are not a great power and never will be again. We are a great nation, but if we continue to behave like a Great Power we shall soon cease to be a great nation. Let us take warning from the fate of the Great Powers of the past and not burst ourselves with pride (see Aesop’s fable of the frog). (1949)

[Recalling Professor Ira Remsen's remarks (1895) to a group of his graduate students about to go out with their degrees into the world beyond the university:]
He talked to us for an hour on what was ahead of us; cautioned us against giving up the desire to push ahead by continued study and work. He warned us against allowing our present accomplishments to be the high spot in our lives. He urged us not to wait for a brilliant idea before beginning independent research, and emphasized the fact the Lavoisier's first contribution to chemistry was the analysis of a sample of gypsum. He told us that the fields in which the great masters had worked were still fruitful; the ground had only been scratched and the gleaner could be sure of ample reward.

Astonishing how great the precautions that are needed in these delicate experiments. Patience. Patience.

Bernard: Oh, you’re going to zap me with penicillin and pesticides. Spare me that and I’ll spare you the bomb and aerosols. But don’t confuse progress with perfectibility. A great poet is always timely. A great philosopher is an urgent need. There’s no rush for Isaac Newton. We were quite happy with Aristotle’s cosmos. Personally, I preferred it. Fifty-five crystal spheres geared to God’s crankshaft is my idea of a satisfying universe. I can’t think of anything more trivial than the speed of light. Quarks, quasars—big bangs, black holes—who [cares]? How did you people con us out of all that status? All that money? And why are you so pleased with yourselves?
Chloe: Are you against penicillin, Bernard?
Bernard: Don’t feed the animals.

Boss: Dilbert, You have been chosen to design the world’s safest nuclear power plant.
Dilbert: This is the great assignment that any engineer could hope for. I'm flattered by the trust you have in me.
Boss: By “safe” I mean “not near my house.”

Ce grand ouvrage, toujours plus merveilleux à mesure qu’il est plus connu, nous donne une si grande idée de son ouvrier, que nous en sentons notre esprit accablé d’admiration et de respect.
[The Universe] This great work, always more amazing in proportion as it is better known, raises in us so grand an idea of its Maker, that we find our mind overwhelmed with feelings of wonder and adoration.

Clarke's First Law - Corollary: When, however, the lay public rallies round an idea that is denounced by distinguished but elderly scientists and supports that idea with great fervor and emotion—the distinguished but elderly scientists are then, after all, probably right.

Die Geschichte der Wissenschaften ist eine grosse Fuge, in der die Stimmen der Völker nach und nach zum Vorschein kommen.
The history of the sciences is a great fugue, in which the voices of the nations come one by one into notice.

Drosophila melanogaster Meigen…has in recent years come to be widely used as a laboratory animal, especially in the study of heredity. Its short life-cycle, great productivity, and the ease with which it may be bred have been chiefly responsible for making it so popular for this purpose.

Hoc age ['do this'] is the great rule, whether you are serious or merry; whether ... learning science or duty from a folio, or floating on the Thames. Intentions must be gathered from acts.

Ich weiss viel. Ich weiss zu viel. Ich bin ein Quantengreis
I know a great deal. I know too much. I am a quantum ancient.

Il n'y a qu'un demi-siècle, un orateur chrétien, se défiant des hommes de la science leur disait: 'Arrêtez-vous enfin, et ne creusez pas jusqu'aux enfers.' Aujourd'hui, Messieurs, rassurés sur l'inébranlable constance de notre foi, nous vous disons: creusez, creusez encore; plus vous descendrez, plus vous rapprocherez du grand mystère de l'impuissance de l'homme et de la vérité de la religion. Creusez donc, creusez toujours,mundum tradidit disputationibus eorum; et quand la science aura donné son dernier coup de marteau sur les fondements de la terre, vous pourrez à la lueur du feu qu'il fera jaillir, lire encore l'idée de Dieu et contempler l'empreinte de sa main.
Only a half-century ago, a Christian speaker, mistrustful of men of science told them: 'Stop finally, and do not dig to hell.' Today, gentlemen, reassured about the steadfastness of our unshakeable faith, we say: dig, dig again; the further down you, the closer you come to the great mystery of the impotence of man and truth of religion. So dig, always dig: and when science has stuck its final hammer blow on the bosom of the earth, you will be able to ignite a burst of light, read furthermore the mind of God and contemplate the imprint of His hand.

L’Astronomie est utile, parce qu’elle nous élève au-dessus de nous-mêmes; elle est utile, parce qu’elle est grande; elle est utile, parce qu’elle est belle… C’est elle qui nous montre combien l’homme est petit par le corps et combien il est grand par l’esprit, puisque cette immensité éclatante où son corps n’est qu’un point obscur, son intelligence peut l’embrasser tout entière et en goûter la silencieuse harmonie.
Astronomy is useful because it raises us above ourselves; it is useful because it is grand[; it is useful because it is beautiful]… It shows us how small is man’s body, how great his mind, since his intelligence can embrace the whole of this dazzling immensity, where his body is only an obscure point, and enjoy its silent harmony.

Le grand architecte de l'univers l'a construite on bons matériaux.
The Great Architect of the universe built it of good firm stuff.

Les grands ponts étant … des monuments qui peuvent servir à faire connoître la magnificence et le génie d’une nation, on ne sauroit trop s’occuper des moyens d’en perfectionner l’architecture, qui peut d’ailleurs être susceptible de variété, en conservant toujours, dans les formes et la décoration, le caractere de solidité qui lui est propre.
Great bridges being monuments which serve to make known the grandeur and genius of a nation, we cannot pay too much attention to means for perfecting their architecture; this may be varied in treatment, but there must ever be conserved, in form and in decoration, the indispensable character of solidity.

Les Leucocytes Et L'esprit De Sacrifice. — Il semble, d'après les recherches de De Bruyne (Phagocytose, 1895) et de ceux qui le citent, que les leucocytes des Lamellibranches — probablement lorsqu'ils ont phagocyté, qu'ils se sont chargés de résidus et de déchets, qu'ils ont, en un mot, accompli leur rôle et bien fait leur devoir — sortent du corps de l'animal et vont mourir dans le milieu ambiant. Ils se sacrifient. Après avoir si bien servi l'organisme par leur activité, ils le servent encore par leur mort en faisant place aux cellules nouvelles, plus jeunes.
N'est-ce pas la parfaite image du désintéressement le plus noble, et n'y a-t-il point là un exemple et un modèle? Il faut s'en inspirer: comme eux, nous sommes les unités d'un grand corps social; comme eux, nous pouvons le servir et envisager la mort avec sérénité, en subordonnant notre conscience individuelle à la conscience collective. (30 Jan 1896)
Leukocytes and The Spirit Of Sacrifice. - It seems, according to research by De Bruyne (Phagocytosis, 1885) and those who quote it, that leukocytes of Lamellibranches [bivalves] - likely when they have phagocytized [ingested bacteria], as they become residues and waste, they have, in short, performed their role well and done their duty - leave the body of the animal and will die in the environment. They sacrifice themselves. Having so well served the body by their activities, they still serve in their death by making room for new younger cells.
Isn't this the perfect image of the noblest selflessness, and thereby presents an example and a model? It should be inspiring: like them, we are the units of a great social body, like them, we can serve and contemplate death with equanimity, subordinating our individual consciousness to collective consciousness.

Magna opera Domini exquisita in omnes voluntates eius.
The works of the Lord are great; sought out of all those that have pleasure therein.

Omnes scientiae sunt connexae et fovent auxiliis sicut partes ejusdem totius, quarum quaelibet opus suum peragit non propter se sed pro aliis.
All sciences are connected; they lend each other material aid as parts of one great whole, each doing its own work, not for itself alone, but for the other parts; as the eye guides the body and the foot sustains it and leads it from place to place.

Pour accomplir de grandes choses il ne suffit pas d'agir il faut rêver; il ne suffit pas de calculer, il faut croire.
To accomplish great things, we must not only act but also dream, not only plan but also believe.
[Referring to the Suez Canal, initiated by Ferdinand de Lesseps.]

Qu. 31. Have not the small Particles of Bodies certain Powers, Virtues or Forces, by which they act at a distance, not only upon the Rays of Light for reflecting, refracting and reflecting them, but also upon one another for producing a great part of the Phænomena of Nature?

Responding to the Bishop of Oxford, Samuel Wilberforce's question whether he traced his descent from an ape on his mother's or his father's side:
If then, said I, the question is put to me would I rather have a miserable ape for a grandfather or a man highly endowed by nature and possessing great means and influence and yet who employs those faculties for the mere purpose of introducing ridicule into a grave scientific discussion—I unhesitatingly affirm my preference for the ape.

Third Fisherman: Master, I marvel how the fishes live in the sea.
First Fisherman: Why, as men do a-land; the great ones eat up the little ones: I can compare our rich misers to nothing so fitly as to a whale; a’ plays and tumbles, driving the poor fry before him, and at last devours them all at a mouthful: such whales have I heard on o’ the land, who never leave gaping till they’ve swallowed the whole parish, church, steeple, bells, and all.

~~[Attributed without source]~~ All scientific men will be delighted to extend their warmest congratulations to Tesla and to express their appreciation of his great contributions to science.

~~[Attributed]~~ A great many people think they are thinking when they are merely rearranging their prejudices.

~~[Misattributed - NOT by Jefferson]~~ I am a great believer in Luck. The harder I work, the more of it I seem to have.

~~[Misattributed]~~ The greatest enemy of progress is the illusion of knowledge.

1122 … Thereafter there were many sailors on the sea and on inland water who said that they had seen a great and extensive fire near the ground in the northeast which continuously increased in width as it mounted to the sky. And the heavens opened into four parts and fought against it as if determined to put it out, and the fire stopped rising upwards. They saw that fire at the first streak of dawn, and it lasted until full daylight: this happened on 7 December.

A … difference between most system-building in the social sciences and systems of thought and classification of the natural sciences is to be seen in their evolution. In the natural sciences both theories and descriptive systems grow by adaptation to the increasing knowledge and experience of the scientists. In the social sciences, systems often issue fully formed from the mind of one man. Then they may be much discussed if they attract attention, but progressive adaptive modification as a result of the concerted efforts of great numbers of men is rare.

A ... hypothesis may be suggested, which supposes the word 'beginning' as applied by Moses in the first of the Book of Genesis, to express an undefined period of time which was antecedent to the last great change that affected the surface of the earth, and to the creation of its present animal and vegetable inhabitants; during which period a long series of operations and revolutions may have been going on, which, as they are wholly unconnected with the history of the human race, are passed over in silence by the sacred historian, whose only concern with them was largely to state, that the matter of the universe is not eternal and self-existent but was originally created by the power of the Almighty.

A cell of a higher organism contains a thousand different substances, arranged in a complex system. This great organized system was not discovered by chemical or physical methods; they are inadequate to its refinement and delicacy and complexity.

A desire to take medicine is, perhaps, the great feature which distinguishes man from other animals.

A discovery in science, or a new theory, even when it appears most unitary and most all-embracing, deals with some immediate element of novelty or paradox within the framework of far vaster, unanalysed, unarticulated reserves of knowledge, experience, faith, and presupposition. Our progress is narrow; it takes a vast world unchallenged and for granted. This is one reason why, however great the novelty or scope of new discovery, we neither can, nor need, rebuild the house of the mind very rapidly. This is one reason why science, for all its revolutions, is conservative. This is why we will have to accept the fact that no one of us really will ever know very much. This is why we shall have to find comfort in the fact that, taken together, we know more and more.

A fateful process is set in motion when the individual is released “to the freedom of his own impotence” and left to justify his existence by his own efforts. The autonomous individual, striving to realize himself and prove his worth, has created all that is great in literature, art, music, science and technology. The autonomous individual, also, when he can neither realize himself nor justify his existence by his own efforts, is a breeding call of frustration, and the seed of the convulsions which shake our world to its foundations.

A few of the results of my activities as a scientist have become embedded in the very texture of the science I tried to serve—this is the immortality that every scientist hopes for. I have enjoyed the privilege, as a university teacher, of being in a position to influence the thought of many hundreds of young people and in them and in their lives I shall continue to live vicariously for a while. All the things I care for will continue for they will be served by those who come after me. I find great pleasure in the thought that those who stand on my shoulders will see much farther than I did in my time. What more could any man want?

A few yes men may be born, but mostly they are made. Fear is a great breeder of them.

A great advantage of X-ray analysis as a method of chemical structure analysis is its power to show some totally unexpected and surprising structure with, at the same time, complete certainty.

A great ball of fire about a mile in diameter, changing colors as it kept shooting upward, from deep purple to orange, expanding, growing bigger, rising as it was expanding, an elemental force freed from its bonds after being chained for billions of years.
On the first atomic explosion in New Mexico, 16 Jul 1945.

A great book is a mine as well as a mint: it suggests and excites as much thought as it presents in finished form.

A great deal of my work is just playing with equations and seeing what they give.

A great deal of the universe does not need any explanation. Elephants, for instance. Once molecules have learnt to compete and to create other molecules in their own image, elephants, and things resembling elephants, will in due course be found roaming around the countryside ... Some of the things resembling elephants will be men.

A great department of thought must have its own inner life, however transcendent may be the importance of its relations to the outside. No department of science, least of all one requiring so high a degree of mental concentration as Mathematics, can be developed entirely, or even mainly, with a view to applications outside its own range. The increased complexity and specialisation of all branches of knowledge makes it true in the present, however it may have been in former times, that important advances in such a department as Mathematics can be expected only from men who are interested in the subject for its own sake, and who, whilst keeping an open mind for suggestions from outside, allow their thought to range freely in those lines of advance which are indicated by the present state of their subject, untrammelled by any preoccupation as to applications to other departments of science. Even with a view to applications, if Mathematics is to be adequately equipped for the purpose of coping with the intricate problems which will be presented to it in the future by Physics, Chemistry and other branches of physical science, many of these problems probably of a character which we cannot at present forecast, it is essential that Mathematics should be allowed to develop freely on its own lines.

A great discovery solves a great problem, but there is a grain of discovery in the solution of any problem. Your problem may be modest, but if it challenges your curiosity and brings into play your inventive faculties, and if you solve it by your own means, you may experience the tension and enjoy the triumph of discovery.

A great invention for dieters would be a refrigerator which weighs you every time you open the door.

A great man quotes bravely, and will not draw on his invention when his memory serves him with a word as good.

A great man, [who] was convinced that the truths of political and moral science are capable of the same certainty as those that form the system of physical science, even in those branches like astronomy that seem to approximate mathematical certainty.
He cherished this belief, for it led to the consoling hope that humanity would inevitably make progress toward a state of happiness and improved character even as it has already done in its knowledge of the truth.

A great nation is any mob of people which produces at least one honest man a century.

A great part of its [higher arithmetic] theories derives an additional charm from the peculiarity that important propositions, with the impress of simplicity on them, are often easily discovered by induction, and yet are of so profound a character that we cannot find the demonstrations till after many vain attempts; and even then, when we do succeed, it is often by some tedious and artificial process, while the simple methods may long remain concealed.

A great reform in geological speculation seems now to have become necessary. … It is quite certain that a great mistake has been made—that British popular geology at the present time is in direct opposition to the principles of Natural Philosophy.

A great surgeon performs operations for stone by a single method; later he makes a statistical summary of deaths and recoveries, and he concludes from these statistics that the mortality law for this operation is two out of five. Well, I say that this ratio means literally nothing scientifically and gives us no certainty in performing the next operation; for we do not know whether the next case will be among the recoveries or the deaths. What really should be done, instead of gathering facts empirically, is to study them more accurately, each in its special determinism. We must study cases of death with great care and try to discover in them the cause of mortal accidents so as to master the cause and avoid the accidents.

A great swindle of our time is the assumption that science has made religion obsolete. All science has damaged is the story of Adam and Eve and the story of Jonah and the Whale. Everything else holds up pretty well, particularly lessons about fairness and gentleness. People who find those lessons irrelevant in the twentieth century are simply using science as an excuse for greed and harshness. Science has nothing to do with it, friends.

A great truth is a truth whose opposite is also a great truth.

A grove of giant redwoods or sequoias should be kept just as we keep a great or beautiful cathedral. The extermination of the passenger pigeon meant that mankind was just so much poorer; exactly as in the case of the destruction of the cathedral at Rheims. And to lose the chance to see frigate-birds soaring in circles above the storm, or a file of pelicans winging their way homeward across the crimson afterglow of the sunset, or a myriad terns flashing in the bright light of midday as they hover in a shifting maze above the beach—why, the loss is like the loss of a gallery of the masterpieces of the artists of old time.