1839—The fermentation satire
THE MYSTERY OF ALCOHOLIC FERMENTATION RESOLVED
(Preliminary Report by Letter) Schwindler
I am about to develop a new theory of wine fermentation … Depending on the weight, these seeds carry fermentation to completion somewhat less than as in the beginning, which is understandable … I shall develop a new theory of wine fermentation [showing] what simple means Nature employs in creating the most amazing phenomena. I owe it to the use of an excellent microscope designed by Pistorius.
When brewer’s yeast is mixed with water the microscope reveals that the yeast dissolves into endless small balls, which are scarcely 1/800th of a line in diameter … If these small balls are placed in sugar water, it can be seen that they consist of the eggs of animals. As they expand, they burst, and from them develop small creatures that multiply with unbelievable rapidity in a most unheard of way. The form of these animals differs from all of the 600 types described up until now. They possess the shape of a Beinsdorff still (without the cooling apparatus). The head of the tube is a sort of proboscis, the inside of which is filled with fine bristles 1/2000th of a line long. Teeth and eyes are not discernible; however, a stomach, intestinal canal, anus (a rose red dot), and organs for secretion of urine are plainly discernible. From the moment they are released from the egg one can see these animals swallow the sugar from the solution and pass it to the stomach. It is digested immediately, a process recognized easily by the resultant evacuation of excrements. In a word, these infusors eat sugar, evacuate ethyl alcohol from the intestinal canal, and carbon dioxide from the urinary organs. The bladder, in the filled state, has the form of a champagne bottle; when empty, it is a small button … As soon as the animals find no more sugar present, they eat each other up, which occurs through a peculiar manipulation; everything is digested down to the eggs which pass unchanged through the intestinal canal. Finally, one again fermentable yeast, namely the seed of the animals, which remain over.

Adrenalin does not excite sympathetic ganglia when applied to them directly, as does nicotine. Its effective action is localised at the periphery. The existence upon plain muscle of a peripheral nervous network, that degenerates only after section of both the constrictor and inhibitory nerves entering it, and not after section of either alone, has been described. I find that even after such complete denervation, whether of three days' or ten months' duration, the plain muscle of the dilatator pupillae will respond to adrenalin, and that with greater rapidity and longer persistence than does the iris whose nervous relations are uninjured. Therefore it cannot be that adrenalin excites any structure derived from, and dependent for its persistence on, the peripheral neurone. But since adrenalin does not evoke any reaction from muscle that has at no time of its life been innervated by the sympathetic, the point at which the stimulus of the chemical excitant is received, and transformed into what may cause the change of tension of the muscle fibre, is perhaps a mechanism developed out of the muscle cell in response to its union with the synapsing sympathetic fibre, the function of which is to receive and transform the nervous impulse. Adrenalin might then be the chemical stimulant liberated on each occasion when the impulse arrives at the periphery.

Because we are urban dwellers we are obsessed with human problems. … We are so alienated from the world of nature that few of us can name the wild flowers and insects of our locality or notice the rapidity of their extinction.

Edison was by far the most successful and, probably, the last exponent of the purely empirical method of investigation. Everything he achieved was the result of persistent trials and experiments often performed at random but always attesting extraordinary vigor and resource. Starting from a few known elements, he would make their combinations and permutations, tabulate them and run through the whole list, completing test after test with incredible rapidity until he obtained a clue. His mind was dominated by one idea, to leave no stone unturned, to exhaust every possibility.

Hitherto the progress of science has been slow, and subject to constant error and revision. But as soon as physical research begins to go hand in hand with moral or psychical research, it will advance with a rapidity hitherto unimagined, each assisting and classifying the other.

Imagination, as well as reason, is necessary to perfection of the philosophical mind. A rapidity of combination, a power of perceiving analogies, and of comparing them by facts, is the creative source of discovery. Discrimination and delicacy of sensation, so important in physical research, are other words for taste; and the love of nature is the same passion, as the love of the magnificent, the sublime and the beautiful.

In summary, very large populations may differentiate rapidly, but their sustained evolution will be at moderate or slow rates and will be mainly adaptive. Populations of intermediate size provide the best conditions for sustained progressive and branching evolution, adaptive in its main lines, but accompanied by inadaptive fluctuations, especially in characters of little selective importance. Small populations will be virtually incapable of differentiation or branching and will often be dominated by random inadaptive trends and peculiarly liable to extinction, but will be capable of the most rapid evolution as long as this is not cut short by extinction.

It is by the aid of iron that we construct houses, cleave rocks, and perform so many other useful offices of life. But it is with iron also that wars, murders, and robberies are effected, and this, not only hand to hand, but from a distance even, by the aid of missiles and winged weapons, now launched from engines, now hurled by the human arm, and now furnished with feathery wings. This last I regard as the most criminal artifice that has been devised by the human mind; for, as if to bring death upon man with still greater rapidity, we have given wings to iron and taught it to fly. ... Nature, in conformity with her usual benevolence, has limited the power of iron, by inflicting upon it the punishment of rust; and has thus displayed her usual foresight in rendering nothing in existence more perishable, than the substance which brings the greatest dangers upon perishable mortality.

It is often claimed that knowledge multiplies so rapidly that nobody can follow it. I believe this is incorrect. At least in science it is not true. The main purpose of science is simplicity and as we understand more things, everything is becoming simpler. This, of course, goes contrary to what everyone accepts.

It may very properly be asked whether the attempt to define distinct species, of a more or less permanent nature, such as we are accustomed to deal with amongst the higher plants and animals, is not altogether illusory amongst such lowly organised forms of life as the bacteria. No biologist nowadays believes in the absolute fixity of species … but there are two circumstances which here render the problem of specificity even more difficult of solution. The bacteriologist is deprived of the test of mutual fertility or sterility, so valuable in determining specific limits amongst organisms in which sexual reproduction prevails. Further, the extreme rapidity with which generation succeeds generation amongst bacteria offers to the forces of variation and natural selection a field for their operation wholly unparalleled amongst higher forms of life.

It occurred to me that if I could invent a machine - a gun - which could by its rapidity of fire, enable one man to do as much battle duty as a hundred, that it would, to a large extent supersede the necessity of large armies, and consequently, exposure to battle and disease [would] be greatly diminished.

MAN, n. An animal so lost in rapturous contemplation of what he thinks he is as to overlook what he indubitably ought to be. His chief occupation is extermination of other animals and his own species, which, however, multiplies with such insistent rapidity as to infest the whole habitable earth and Canada.

Mathematics is the study which forms the foundation of the course [at West Point Military Academy]. This is necessary, both to impart to the mind that combined strength and versatility, the peculiar vigor and rapidity of comparison necessary for military action, and to pave the way for progress in the higher military sciences.

One feature which will probably most impress the mathematician accustomed to the rapidity and directness secured by the generality of modern methods is the deliberation with which Archimedes approaches the solution of any one of his main problems. Yet this very characteristic, with its incidental effects, is calculated to excite the more admiration because the method suggests the tactics of some great strategist who foresees everything, eliminates everything not immediately conducive to the execution of his plan, masters every position in its order, and then suddenly (when the very elaboration of the scheme has almost obscured, in the mind of the spectator, its ultimate object) strikes the final blow. Thus we read in Archimedes proposition after proposition the bearing of which is not immediately obvious but which we find infallibly used later on; and we are led by such easy stages that the difficulties of the original problem, as presented at the outset, are scarcely appreciated. As Plutarch says: “It is not possible to find in geometry more difficult and troublesome questions, or more simple and lucid explanations.” But it is decidedly a rhetorical exaggeration when Plutarch goes on to say that we are deceived by the easiness of the successive steps into the belief that anyone could have discovered them for himself. On the contrary, the studied simplicity and the perfect finish of the treatises involve at the same time an element of mystery. Though each step depends on the preceding ones, we are left in the dark as to how they were suggested to Archimedes. There is, in fact, much truth in a remark by Wallis to the effect that he seems “as it were of set purpose to have covered up the traces of his investigation as if he had grudged posterity the secret of his method of inquiry while he wished to extort from them assent to his results.” Wallis adds with equal reason that not only Archimedes but nearly all the ancients so hid away from posterity their method of Analysis (though it is certain that they had one) that more modern mathematicians found it easier to invent a new Analysis than to seek out the old.

Science has hitherto been proceeding without the guidance of any rational theory of logic, and has certainly made good progress. It is like a computer who is pursuing some method of arithmetical approximation. Even if he occasionally makes mistakes in his ciphering, yet if the process is a good one they will rectify themselves. But then he would approximate much more rapidly if he did not commit these errors; and in my opinion, the time has come when science ought to be provided with a logic. My theory satisfies me; I can see no flaw in it. According to that theory universality, necessity, exactitude, in the absolute sense of these words, are unattainable by us, and do not exist in nature. There is an ideal law to which nature approximates; but to express it would require an endless series of modifications, like the decimals expressing surd. Only when you have asked a question in so crude a shape that continuity is not involved, is a perfectly true answer attainable.

Science quickens and cultivates directly the faculty of observation, which in very many persons lies almost dormant through life, the power of accurate and rapid generalizations, and the mental habit of method and arrangement; it accustoms young persons to trace the sequence of cause and effect; it familiarizes then with a kind of reasoning which interests them, and which they can promptly comprehend; and it is perhaps the best corrective for that indolence which is the vice of half-awakened minds, and which shrinks from any exertion that is not, like an effort of memory, merely mechanical.

The fact that all normal children acquire essentially comparable grammars of great complexity with remarkable rapidity suggests that human beings are somehow specially designed to do this, with data-handling or 'hypothesis-formulating' ability of unknown character and complexity.

The great rapidity with which we add carbon gases to the air is as damaging as is the quantity.

The injurious agent in cigarettes comes principally from the burning paper wrapper. The substance thereby formed is called “acrolein.” It has a violent action on the nerve centers, producing degeneration of the cells of the brain, which is quite rapid among boys. Unlike most narcotics, this degeneration is permanent and uncontrollable. I employ no person who smokes cigarettes.
[From the Laboratory of Thomas A. Edison, Orange, N.J., April 26, 1914.]

The rapid growth of industry, the ever increasing population and the imperative need for more varied, wholesome and nourishing foodstuff makes it all the more necessary to exhaust every means at our command to fill the empty dinner pail, enrich our soils, bring greater wealth and influence to our beautiful South land, which is synonymous to a healthy, happy and contented people.

The sooner patients can be removed from the depressing influence of general hospital life the more rapid their convalescence.

The spectacular thing about Johnny [von Neumann] was not his power as a mathematician, which was great, or his insight and his clarity, but his rapidity; he was very, very fast. And like the modern computer, which no longer bothers to retrieve the logarithm of 11 from its memory (but, instead, computes the logarithm of 11 each time it is needed), Johnny didn’t bother to remember things. He computed them. You asked him a question, and if he didn’t know the answer, he thought for three seconds and would produce and answer.

The theory here developed is that mega-evolution normally occurs among small populations that become preadaptive and evolve continuously (without saltation, but at exceptionally rapid rates) to radically different ecological positions. The typical pattern involved is probably this: A large population is fragmented into numerous small isolated lines of descent. Within these, inadaptive differentiation and random fixation of mutations occur. Among many such inadaptive lines one or a few are preadaptive, i.e., some of their characters tend to fit them for available ecological stations quite different from those occupied by their immediate ancestors. Such groups are subjected to strong selection pressure and evolve rapidly in the further direction of adaptation to the new status. The very few lines that successfully achieve this perfected adaptation then become abundant and expand widely, at the same time becoming differentiated and specialized on lower levels within the broad new ecological zone.

The unprecedented development of science and technology... so rapid that it is said that 90 per cent of the scientists which this country has ever produced are still living today.

The year 1896 … marked the beginning of what has been aptly termed the heroic age of Physical Science. Never before in the history of physics has there been witnessed such a period of intense activity when discoveries of fundamental importance have followed one another with such bewildering rapidity.

Till the fifteenth century little progress appears to have been made in the science or practice of music; but since that era it has advanced with marvelous rapidity, its progress being curiously parallel with that of mathematics, inasmuch as great musical geniuses appeared suddenly among different nations, equal in their possession of this special faculty to any that have since arisen. As with the mathematical so with the musical faculty it is impossible to trace any connection between its possession and survival in the struggle for existence.

Tis evident that all reasonings concerning matter of fact are founded on the relation of cause and effect, and that we can never infer the existence of one object from another, unless they be connected together, either mediately or immediately... Here is a billiard ball lying on the table, and another ball moving toward it with rapidity. They strike; and the ball which was formerly at rest now acquires a motion. This is as perfect an instance of the relation of cause and effect as any which we know, either by sensation or reflection.

Unless man can make new and original adaptations to his environment as rapidly as his science can change the environment, our culture will perish.

When two minds of a high order, interested in kindred subjects, come together, their conversation is chiefly remarkable for the summariness of its allusions and the rapidity of its transitions. Before one of them is half through a sentence the other knows his meaning and replies. ... His mental lungs breathe more deeply, in an atmosphere more broad and vast...