…nature seems very conversant with the rules of pure mathematics, as our own mathematicians have formulated them in their studies, out of their own inner consciousness and without drawing to any appreciable extent on their experience of the outer world.

...those who sit at their work and are therefore called 'chair workers,' such as cobblers and tailors, suffer from their own particular diseases ... [T]hese workers ... suffer from general ill-health and an excessive accumulation of unwholesome humors caused by their sedentary life ... so to some extent counteract the harm done by many days of sedentary life.
On the association between chronic inactivity and poor health. Ramazzini urged that workers should at least exercise on holidays

’Tis evident, that as common Air when reduc’d to half Its wonted extent, obtained near about twice as forcible a Spring as it had before; so this thus- comprest Air being further thrust into half this narrow room, obtained thereby a Spring about as strong again as that It last had, and consequently four times as strong as that of the common Air. And there is no cause to doubt, that If we had been here furnisht with a greater quantity of Quicksilver and a very long Tube, we might by a further compression of the included Air have made It counter-balance “the pressure” of a far taller and heavier Cylinder of Mercury. For no man perhaps yet knows how near to an infinite compression the Air may be capable of, If the compressing force be competently increast.

“Heaven helps those who help themselves” is a well-tried maxim, embodying in a small compass the results of vast human experience. The spirit of self-help is the root of all genuine growth in the individual; and, exhibited in the lives of many, it constitutes the true source of national vigour and strength. Help from without is often enfeebling in its effects, but help from within invariably invigorates. Whatever is done for men or classes, to a certain extent takes away the stimulus and necessity of doing for themselves; and where men are subjected to over-guidance and over-government, the inevitable tendency is to render them comparatively helpless.

[An outsider views a scientist] as a type of unscrupulous opportunist: he appears as a realist, insofar as he seeks to describe the world independent of the act of perception; as idealist insofar as he looks upon the concepts and theories as the free inventions of the human spirit (not logically derivable from that which is empirically given); as positivist insofar as he considers his concepts and theories justified only to the extent to which they furnish a logical representation of relations among sense experiences. He may even appear as Platonist or Pythagorean insofar as he considers the viewpoint of logical simplicity as an indispensable and effective tool of his research.

[At high school in Cape Town] my interests outside my academic work were debating, tennis, and to a lesser extent, acting. I became intensely interested in astronomy and devoured the popular works of astronomers such as Sir Arthur Eddington and Sir James Jeans, from which I learnt that a knowledge of mathematics and physics was essential to the pursuit of astronomy. This increased my fondness for those subjects.

[Euclid's Elements] has been for nearly twenty-two centuries the encouragement and guide of that scientific thought which is one thing with the progress of man from a worse to a better state. The encouragement; for it contained a body of knowledge that was really known and could be relied on, and that moreover was growing in extent and application. For even at the time this book was written—shortly after the foundation of the Alexandrian Museum—Mathematics was no longer the merely ideal science of the Platonic school, but had started on her career of conquest over the whole world of Phenomena. The guide; for the aim of every scientific student of every subject was to bring his knowledge of that subject into a form as perfect as that which geometry had attained. Far up on the great mountain of Truth, which all the sciences hope to scale, the foremost of that sacred sisterhood was seen, beckoning for the rest to follow her. And hence she was called, in the dialect of the Pythagoreans, ‘the purifier of the reasonable soul.’

[Haunted by the statistic that the best predictor of SAT scores is family income:] Where you were born, into what family you are born, what their resources are, are to a large extent are going to determine the quality of education you receive, beginning in preschool and moving all the way up through college.
And what this is going to create in America is a different kind of aristocracy that's going to be self-perpetuating, unless we find ways to break that juggernaut.
... I think what that really reflects is the fact that resources, and not wealth necessarily, but just good middle-class resources, can buy quality of experience for children.

[In mathematics] we behold the conscious logical activity of the human mind in its purest and most perfect form. Here we learn to realize the laborious nature of the process, the great care with which it must proceed, the accuracy which is necessary to determine the exact extent of the general propositions arrived at, the difficulty of forming and comprehending abstract concepts; but here we learn also to place confidence in the certainty, scope and fruitfulness of such intellectual activity.

A mind not wholly wishful to reach the truth, or to rest it in or obey it when found, is to that extent a mind impervious to truth an incapable of unbiased belief.

A mouse can fall down a mine shaft a third of a mile deep without injury. A rat falling the same distance would break his bones; a man would simply splash ... Elephants have their legs thickened to an extent that seems disproportionate to us, but this is necessary if their unwieldly bulk is to be moved at all ... A 60-ft. man would weigh 1000 times as much as a normal man, but his thigh bone would have its area increased by only 100 times ... Consequently such an unfortunate monster would break his legs the moment he tried to move.
Expressing, in picturesque terms, the strength of an organism relative to its bulk.

Again, it [the Analytical Engine] might act upon other things besides number, were objects found whose mutual fundamental relations could be expressed by those of the abstract science of operations, and which should be also susceptible of adaptations to the action of the operating notation and mechanism of the engine. Supposing for instance, that the fundamental relations of pitched sounds in the science of harmony and of musical composition were susceptible of such expression and adaptations, the engine might compose elaborate and scientific pieces of music of any degree of complexity or extent.

All scientists must focus closely on limited targets. Whether or not one’s findings on a limited subject will have wide applicability depends to some extent on chance, but biologists of superior ability repeatedly focus on questions the answers to which either have wide ramifications or lead to new areas of investigation. One procedure that can be effective is to attempt both reduction and synthesis; that is, direct a question at a phenomenon on one integrative level, identify its mechanism at a simpler level, then extrapolate its consequences to a more complex level of integration.

Americans have always believed that—within the law—all kinds of people should be allowed to take the initiative in all kinds of activities. And out of that pluralism has come virtually all of our creativity. Freedom is real only to the extent that there are diverse alternatives.

And now, as a germination of planetary dimensions, comes the thinking layer which over its full extent develops and intertwines its fibres, not to confuse and neutralise them but to reinforce them in the living unity of a single tissue.

As arithmetic and algebra are sciences of great clearness, certainty, and extent, which are immediately conversant about signs, upon the skilful use whereof they entirely depend, so a little attention to them may possibly help us to judge of the progress of the mind in other sciences, which, though differing in nature, design, and object, may yet agree in the general methods of proof and inquiry.

As I looked down, I saw a large river meandering slowly along for miles, passing from one country to another without stopping. I also saw huge forests, extending along several borders. And I watched the extent of one ocean touch the shores of separate continents. Two words leaped to mind as I looked down on all this: commonality and interdependence. We are one world.

At the entrance to the observatory Stjerneborg located underground, Tycho Brahe built a Ionic portal. On top of this were three sculptured lions. On both sides were inscriptions and on the backside was a longer inscription in gold letters on a porfyr stone: Consecrated to the all-good, great God and Posterity. Tycho Brahe, Son of Otto, who realized that Astronomy, the oldest and most distinguished of all sciences, had indeed been studied for a long time and to a great extent, but still had not obtained sufficient firmness or had been purified of errors, in order to reform it and raise it to perfection, invented and with incredible labour, industry, and expenditure constructed various exact instruments suitable for all kinds of observations of the celestial bodies, and placed them partly in the neighbouring castle of Uraniborg, which was built for the same purpose, partly in these subterranean rooms for a more constant and useful application, and recommending, hallowing, and consecrating this very rare and costly treasure to you, you glorious Posterity, who will live for ever and ever, he, who has both begun and finished everything on this island, after erecting this monument, beseeches and adjures you that in honour of the eternal God, creator of the wonderful clockwork of the heavens, and for the propagation of the divine science and for the celebrity of the fatherland, you will constantly preserve it and not let it decay with old age or any other injury or be removed to any other place or in any way be molested, if for no other reason, at any rate out of reverence to the creator’s eye, which watches over the universe. Greetings to you who read this and act accordingly. Farewell!

Common to all these types is the anthropomorphic character of their conception of God. In general, only individuals of exceptional endowments, and exceptionally high-minded communities, rise to any considerable extent above this level. But there is a third stage of religious experience which belongs to all of them, even though it is rarely found in a pure form: I shall call it cosmic religious feeling. It is very difficult to elucidate this feeling to anyone who is entirely without it, especially as there is no anthropomorphic conception of God corresponding to it.

Communication of science as subject-matter has so far outrun in education the construction of a scientific habit of mind that to some extent the natural common sense of mankind has been interfered with to its detriment.

Compare the length of a moment with the period of ten thousand years; the first, however minuscule, does exist as a fraction of a second. But that number of years, or any multiple of it that you may name, cannot even be compared with a limitless extent of time, the reason being that comparisons can be drawn between finite things, but not between finite and infinite.

Einstein, twenty-six years old, only three years away from crude privation, still a patent examiner, published in the Annalen der Physik in 1905 five papers on entirely different subjects. Three of them were among the greatest in the history of physics. One, very simple, gave the quantum explanation of the photoelectric effect—it was this work for which, sixteen years later, he was awarded the Nobel prize. Another dealt with the phenomenon of Brownian motion, the apparently erratic movement of tiny particles suspended in a liquid: Einstein showed that these movements satisfied a clear statistical law. This was like a conjuring trick, easy when explained: before it, decent scientists could still doubt the concrete existence of atoms and molecules: this paper was as near to a direct proof of their concreteness as a theoretician could give. The third paper was the special theory of relativity, which quietly amalgamated space, time, and matter into one fundamental unity.
This last paper contains no references and quotes no authority. All of them are written in a style unlike any other theoretical physicist’s. They contain very little mathematics. There is a good deal of verbal commentary. The conclusions, the bizarre conclusions, emerge as though with the greatest of ease: the reasoning is unbreakable. It looks as though he had reached the conclusions by pure thought, unaided, without listening to the opinions of others. To a surprisingly large extent, that is precisely what he had done.

Even happiness itself may become habitual. There is a habit of looking at the bright side of things, and also of looking at the dark side. Dr. Johnson has said that the habit of looking at the best side of a thing is worth more to a man than a thousand pounds a year. And we possess the power, to a great extent, of so exercising the will as to direct the thoughts upon objects calculated to yield happiness and improvement rather than their opposites.

Every scientist is an agent of cultural change. He may not be a champion of change; he may even resist it, as scholars of the past resisted the new truths of historical geology, biological evolution, unitary chemistry, and non-Euclidean geometry. But to the extent that he is a true professional, the scientist is inescapably an agent of change. His tools are the instruments of change—skepticism, the challenge to establish authority, criticism, rationality, and individuality.

First, as concerns the success of teaching mathematics. No instruction in the high schools is as difficult as that of mathematics, since the large majority of students are at first decidedly disinclined to be harnessed into the rigid framework of logical conclusions. The interest of young people is won much more easily, if sense-objects are made the starting point and the transition to abstract formulation is brought about gradually. For this reason it is psychologically quite correct to follow this course.
Not less to be recommended is this course if we inquire into the essential purpose of mathematical instruction. Formerly it was too exclusively held that this purpose is to sharpen the understanding. Surely another important end is to implant in the student the conviction that correct thinking based on true premises secures mastery over the outer world. To accomplish this the outer world must receive its share of attention from the very beginning.
Doubtless this is true but there is a danger which needs pointing out. It is as in the case of language teaching where the modern tendency is to secure in addition to grammar also an understanding of the authors. The danger lies in grammar being completely set aside leaving the subject without its indispensable solid basis. Just so in Teaching of Mathematics it is possible to accumulate interesting applications to such an extent as to stunt the essential logical development. This should in no wise be permitted, for thus the kernel of the whole matter is lost. Therefore: We do want throughout a quickening of mathematical instruction by the introduction of applications, but we do not want that the pendulum, which in former decades may have inclined too much toward the abstract side, should now swing to the other extreme; we would rather pursue the proper middle course.

I attained a triumph so complete that it is now rare to meet an American with marks of small pox on his face... Benefits are valuable according to their duration and extent, like the showers from heaven, but the benign remedy Vaccination saves millions of lives every century, like the blessing of the sun, universal and everlasting.
(Remark made near the end of his life.)

I can understand your aversion to the use of the term ‘religion’ to describe an emotional and psychological attitude which shows itself most clearly in Spinoza ... I have not found a better expression than ‘religious’ for the trust in the rational nature of reality that is, at least to a certain extent, accessible to human reason.

I confess that Fermat’s Theorem as an isolated proposition has very little interest for me, for a multitude of such theorems can easily be set up, which one could neither prove nor disprove. But I have been stimulated by it to bring our again several old ideas for a great extension of the theory of numbers. Of course, this theory belongs to the things where one cannot predict to what extent one will succeed in reaching obscurely hovering distant goals. A happy star must also rule, and my situation and so manifold distracting affairs of course do not permit me to pursue such meditations as in the happy years 1796-1798 when I created the principal topics of my Disquisitiones arithmeticae. But I am convinced that if good fortune should do more than I expect, and make me successful in some advances in that theory, even the Fermat theorem will appear in it only as one of the least interesting corollaries.
In reply to Olbers' attempt in 1816 to entice him to work on Fermat's Theorem. The hope Gauss expressed for his success was never realised.

I consider that a man’s brain originally is like a little empty attic, and you have to stock it with such furniture as you choose. A fool takes in all the lumber of every sort that he comes across, so that the knowledge which might be useful to him gets crowded out, or at best is jumbled up with a lot of other things so that he has a difficulty in laying his hands upon it. Now the skilful workman is very careful indeed as to what he takes into his brain-attic. He will have nothing but the tools which may help him in doing his work, but of these he has a large assortment, and all in the most perfect order. It is a mistake to think that that little room has elastic walls and can distend to any extent. Depend upon it there comes a time when for every addition of knowledge you forget something that you knew before. It is of the highest importance, therefore, not to have useless facts elbowing out the useful ones.

I feel very strongly indeed that a Cambridge education for our scientists should include some contact with the humanistic side. The gift of expression is important to them as scientists; the best research is wasted when it is extremely difficult to discover what it is all about ... It is even more important when scientists are called upon to play their part in the world of affairs, as is happening to an increasing extent.

I have always assumed, and I now assume, that he [Robert Oppenheimer] is loyal to the United States. I believe this, and I shall believe it until I see very conclusive proof to the opposite. … [But] I thoroughly disagreed with him in numerous issues and his actions frankly appeared to me confused and complicated. To this extent I feel that I would like to see the vital interests of this country in hands which I understand better, and therefore trust more.

I have always felt that I understood a phenomenon only to the extent that I could visualise it. Much of the charm organic chemical research has for me derives from structural formulae. When reading chemical journals, I look for formulae first.

I presume that few who have paid any attention to the history of the Mathematical Analysis, will doubt that it has been developed in a certain order, or that that order has been, to a great extent, necessary—being determined, either by steps of logical deduction, or by the successive introduction of new ideas and conceptions, when the time for their evolution had arrived. And these are the causes that operate in perfect harmony. Each new scientific conception gives occasion to new applications of deductive reasoning; but those applications may be only possible through the methods and the processes which belong to an earlier stage.

I should like to compare this rearrangement which the proteins undergo in the animal or vegetable organism to the making up of a railroad train. In their passage through the body parts of the whole may be left behind, and here and there new parts added on. In order to understand fully the change we must remember that the proteins are composed of Bausteine united in very different ways. Some of them contain Bausteine of many kinds. The multiplicity of the proteins is determined by many causes, first through the differences in the nature of the constituent Bausteine; and secondly, through differences in the arrangement of them. The number of Bausteine which may take part in the formation of the proteins is about as large as the number of letters in the alphabet. When we consider that through the combination of letters an infinitely large number of thoughts may be expressed, we can understand how vast a number of the properties of the organism may be recorded in the small space which is occupied by the protein molecules. It enables us to understand how it is possible for the proteins of the sex-cells to contain, to a certain extent, a complete description of the species and even of the individual. We may also comprehend how great and important the task is to determine the structure of the proteins, and why the biochemist has devoted himself with so much industry to their analysis.

I thank thee, O Lord, our Creator, that thou hast permitted me to look at the beauty in thy work of creation; I exult in the works of thy hands. See, I have completed the work to which I felt called; I have earned interest from the talent that thou hast given me. I have proclaimed the glory of thy works to the people who will read these demonstrations, to the extent that the limitations of my spirit would allow.

If these d'Hérelle bodies were really genes, fundamentally like our chromosome genes, they would give us an utterly new angle from which to attack the gene problem. They are filterable, to some extent isolable, can be handled in test-tubes, and their properties, as shown by their effects on the bacteria, can then be studied after treatment. It would be very rash to call these bodies genes, and yet at present we must confess that there is no distinction known between the genes and them. Hence we can not categorically deny that perhaps we may be able to grind genes in a mortar and cook them in a beaker after all. Must we geneticists become bacteriologists, physiological chemists and physicists, simultaneously with being zoologists and botanists? Let us hope so.

If we consider that part of the theory of relativity which may nowadays in a sense be regarded as bone fide scientific knowledge, we note two aspects which have a major bearing on this theory. The whole development of the theory turns on the question of whether there are physically preferred states of motion in Nature (physical relativity problem). Also, concepts and distinctions are only admissible to the extent that observable facts can be assigned to them without ambiguity (stipulation that concepts and distinctions should have meaning). This postulate, pertaining to epistemology, proves to be of fundamental importance.

In describing a protein it is now common to distinguish the primary, secondary and tertiary structures. The primary structure is simply the order, or sequence, of the amino-acid residues along the polypeptide chains. This was first determined by Sanger using chemical techniques for the protein insulin, and has since been elucidated for a number of peptides and, in part, for one or two other small proteins. The secondary structure is the type of folding, coiling or puckering adopted by the polypeptide chain: the a-helix structure and the pleated sheet are examples. Secondary structure has been assigned in broad outline to a number of librous proteins such as silk, keratin and collagen; but we are ignorant of the nature of the secondary structure of any globular protein. True, there is suggestive evidence, though as yet no proof, that a-helices occur in globular proteins, to an extent which is difficult to gauge quantitatively in any particular case. The tertiary structure is the way in which the folded or coiled polypeptide chains are disposed to form the protein molecule as a three-dimensional object, in space. The chemical and physical properties of a protein cannot be fully interpreted until all three levels of structure are understood, for these properties depend on the spatial relationships between the amino-acids, and these in turn depend on the tertiary and secondary structures as much as on the primary. Only X-ray diffraction methods seem capable, even in principle, of unravelling the tertiary and secondary structures.
Co-author with G. Bodo, H. M. Dintzis, R. G. Parrish, H. Wyckoff, and D. C. Phillips

In Man the brain presents an ascensive step in development, higher and more strongly marked than that by which the preceding subclass was distinguished from the one below it. Not only do the cerebral hemispheres overlap the olfactory lobes and cerebellum, but they extend in advance of the one, and further back than the other. Their posterior development is so marked, that anatomists have assigned to that part the character of a third lobe; it is peculiar to the genus Homo, and equally peculiar is the 'posterior horn of the lateral ventricle,' and the 'hippocampus minor,' which characterize the hind lobe of each hemisphere. The superficial grey matter of the cerebrum, through the number and depth of the convolutions, attains its maximum of extent in Man. Peculiar mental powers are associated with this highest form of brain, and their consequences wonderfully illustrate the value of the cerebral character; according to my estimate of which, I am led to regard the genus Homo, as not merely a representative of a distinct order, but of a distinct subclass of the Mammalia, for which I propose a name of 'ARCHENCEPHALA.'

In order to pursue chemotherapy successfully we must look for substances which possess a high affinity and high lethal potency in relation to the parasites, but have a low toxicity in relation to the body, so that it becomes possible to kill the parasites without damaging the body to any great extent. We want to hit the parasites as selectively as possible. In other words, we must learn to aim and to aim in a chemical sense. The way to do this is to synthesize by chemical means as many derivatives as possible of relevant substances.

In our day grand generalizations have been reached. The theory of the origin of species is but one of them. Another, of still wider grasp and more radical significance, is the doctrine of the Conservation of Energy, the ultimate philosophical issues of which are as yet but dimly seem-that doctrine which “binds nature fast in fate” to an extent not hitherto recognized, exacting from every antecedent its equivalent consequent, and bringing vital as well as physical phenomena under the dominion of that law of causal connexion which, so far as the human understanding has yet pierced, asserts itself everywhere in nature.

In the benzene nucleus we have been given a soil out of which we can see with surprise the already-known realm of organic chemistry multiply, not once or twice but three, four, five or six times just like an equivalent number of trees. What an amount of work had suddenly become necessary, and how quickly were busy hands found to carry it out! First the eye moves up the six stems opening out from the tremendous benzene trunk. But already the branches of the neighbouring stems have become intertwined, and a canopy of leaves has developed which becomes more spacious as the giant soars upwards into the air. The top of the tree rises into the clouds where the eye cannot yet follow it. And to what an extent is this wonderful benzene tree thronged with blossoms! Everywhere in the sea of leaves one can spy the slender hydroxyl bud: hardly rarer is the forked blossom [Gabelblüte] which we call the amine group, the most frequent is the beautiful cross-shaped blossom we call the methyl group. And inside this embellishment of blossoms, what a richness of fruit, some of them shining in a wonderful blaze of color, others giving off an overwhelming fragrance.

In time, manufacturing will to a great extent follow the sun.
[Speculating that with development of solar power the deserts would become great industrial areas.]

Intravenous injections of extract from dog’s pancreas, removed from seven to ten weeks after ligation of the ducts, invariably exercises a reducing influence upon the percentage sugar of the blood and the amount of sugar excreted in the urine … the extent and duration of the reduction varies directly with the amount of extract injected.

It has been asserted … that the power of observation is not developed by mathematical studies; while the truth is, that; from the most elementary mathematical notion that arises in the mind of a child to the farthest verge to which mathematical investigation has been pushed and applied, this power is in constant exercise. By observation, as here used, can only be meant the fixing of the attention upon objects (physical or mental) so as to note distinctive peculiarities—to recognize resemblances, differences, and other relations. Now the first mental act of the child recognizing the distinction between one and more than one, between one and two, two and three, etc., is exactly this. So, again, the first geometrical notions are as pure an exercise of this power as can be given. To know a straight line, to distinguish it from a curve; to recognize a triangle and distinguish the several forms—what are these, and all perception of form, but a series of observations? Nor is it alone in securing these fundamental conceptions of number and form that observation plays so important a part. The very genius of the common geometry as a method of reasoning—a system of investigation—is, that it is but a series of observations. The figure being before the eye in actual representation, or before the mind in conception, is so closely scrutinized, that all its distinctive features are perceived; auxiliary lines are drawn (the imagination leading in this), and a new series of inspections is made; and thus, by means of direct, simple observations, the investigation proceeds. So characteristic of common geometry is this method of investigation, that Comte, perhaps the ablest of all writers upon the philosophy of mathematics, is disposed to class geometry, as to its method, with the natural sciences, being based upon observation. Moreover, when we consider applied mathematics, we need only to notice that the exercise of this faculty is so essential, that the basis of all such reasoning, the very material with which we build, have received the name observations. Thus we might proceed to consider the whole range of the human faculties, and find for the most of them ample scope for exercise in mathematical studies. Certainly, the memory will not be found to be neglected. The very first steps in number—counting, the multiplication table, etc., make heavy demands on this power; while the higher branches require the memorizing of formulas which are simply appalling to the uninitiated. So the imagination, the creative faculty of the mind, has constant exercise in all original mathematical investigations, from the solution of the simplest problems to the discovery of the most recondite principle; for it is not by sure, consecutive steps, as many suppose, that we advance from the known to the unknown. The imagination, not the logical faculty, leads in this advance. In fact, practical observation is often in advance of logical exposition. Thus, in the discovery of truth, the imagination habitually presents hypotheses, and observation supplies facts, which it may require ages for the tardy reason to connect logically with the known. Of this truth, mathematics, as well as all other sciences, affords abundant illustrations. So remarkably true is this, that today it is seriously questioned by the majority of thinkers, whether the sublimest branch of mathematics,—the infinitesimal calculus—has anything more than an empirical foundation, mathematicians themselves not being agreed as to its logical basis. That the imagination, and not the logical faculty, leads in all original investigation, no one who has ever succeeded in producing an original demonstration of one of the simpler propositions of geometry, can have any doubt. Nor are induction, analogy, the scrutinization of premises or the search for them, or the balancing of probabilities, spheres of mental operations foreign to mathematics. No one, indeed, can claim preeminence for mathematical studies in all these departments of intellectual culture, but it may, perhaps, be claimed that scarcely any department of science affords discipline to so great a number of faculties, and that none presents so complete a gradation in the exercise of these faculties, from the first principles of the science to the farthest extent of its applications, as mathematics.

It is a right, yes a duty, to search in cautious manner for the numbers, sizes, and weights, the norms for everything [God] has created. For He himself has let man take part in the knowledge of these things ... For these secrets are not of the kind whose research should be forbidden; rather they are set before our eyes like a mirror so that by examining them we observe to some extent the goodness and wisdom of the Creator.

It is certain that as a nation we are all smoking a great deal too much ... Smoking among boys—to whom it cannot possibly do any kind of good, while it may do a vast amount of active harm—is becoming prevalent to a most pernicious extent. ... It would be an excellent thing for the morality of the people could the use of “intoxicants and tobacco” be forbidden to all persons under twenty years of age. (1878)

It is clear that the degradation of the position of the scientist as an independent worker and thinker to that of a morally irresponsible stooge in a science-factory has ‘proceeded even more rapidly and devastatingly than I had expected. This subordination of those who ought to think to those who have the administrative power is ruinous for the morale of the scientist, and quite to the same extent it is ruinous to the quality of the subjective scientific output of the country.

It is difficult to give an idea of the vast extent of modern mathematics. The word “extent” is not the right one: I mean extent crowded with beautiful detail—not an extent of mere uniformity such as an objectless plain, but of a tract of beautiful country seen at first in the distance, but which will bear to be rambled through and studied in every detail of hillside and valley, stream, rock, wood, and flower.

It is only in mathematics, and to some extent in poetry, that originality may be attained at an early age, but even then it is very rare (Newton and Keats are examples), and it is not notable until adolescence is completed.

It is only necessary to check the comic books and Reader’s Digest to see the extent of the influence of applied science on the popular imagination. How much it is used to provide an atmosphere of endless thrill and excitement, quite apart from its accidental menace or utility, one can decide from such typical daily headlines as these:
London, March 10, 1947, Reuters: ROCKET TO MOON SEEN POSSIBLE BUT THOUSANDS TO DIE IN ATTEMPT
Cleveland, January 5, 1948.: LIFE SPAN OF 100, BE YOUNG AT 80, ATOM PREDICTION
Washington, June 11, 1947: SCIENTISTS AWAIT COW’S DEATH TO SOLVE MATHEMATICS PROBLEM
Needham Market, Suffolk, England. (U.P.): VICAR PROPOSES BABIES FOR YEARNING SPINSTERS, TEST-TUBE BABIES WILL PRODUCE ROBOTS
Washington, D.C., January 3, 1948. U.S. FLYER PASSING SONIC BARRIER OPENS NEW VISTAS OF DESTRUCTION ONE OF BRAVEST ACTS IN HISTORY
Those headlines represent “human interest” attempts to gear science to the human nervous system.

It need scarcely be pointed out that with such a mechanism complete isolation of portion of a species should result relatively rapidly in specific differentiation, and one that is not necessarily adaptive. The effective inter­group competition leading to adaptive advance may be between species rather than races. Such isolation is doubtless usually geographic in character at the outset but may be clinched by the development of hybrid sterility. The usual difference of the chromosome complements of related species puts the importance of chromosome aberration as an evolutionary process beyond question, but, as I see it, this importance is not in the character differences which they bring (slight in balanced types), but rather in leading to the sterility of hybrids and thus making permanent the isolation of two groups.
How far do the observations of actual species and their subdivisions conform to this picture? This is naturally too large a subject for more than a few suggestions.
That evolution involves non-adaptive differentiation to a large extent at the subspecies and even the species level is indicated by the kinds of differences by which such groups are actually distinguished by systematics. It is only at the subfamily and family levels that clear-cut adaptive differences become the rule. The principal evolutionary mechanism in the origin of species must thus be an essentially nonadaptive one.

It occurred to me that if I could invent a machine - a gun - which could by its rapidity of fire, enable one man to do as much battle duty as a hundred, that it would, to a large extent supersede the necessity of large armies, and consequently, exposure to battle and disease [would] be greatly diminished.

It would not be difficult to come to an agreement as to what we understand by science. Science is the century-old endeavor to bring together by means of systematic thought the perceptible phenomena of this world into as thoroughgoing an association as possible. To put it boldly, it is the attempt at the posterior reconstruction of existence by the process of conceptualization. But when asking myself what religion is I cannot think of the answer so easily. And even after finding an answer which may satisfy me at this particular moment, I still remain convinced that I can never under any circumstances bring together, even to a slight extent, the thoughts of all those who have given this question serious consideration.

It would seem at first sight as if the rapid expansion of the region of mathematics must be a source of danger to its future progress. Not only does the area widen but the subjects of study increase rapidly in number, and the work of the mathematician tends to become more and more specialized. It is, of course, merely a brilliant exaggeration to say that no mathematician is able to understand the work of any other mathematician, but it is certainly true that it is daily becoming more and more difficult for a mathematician to keep himself acquainted, even in a general way, with the progress of any of the branches of mathematics except those which form the field of his own labours. I believe, however, that the increasing extent of the territory of mathematics will always be counteracted by increased facilities in the means of communication. Additional knowledge opens to us new principles and methods which may conduct us with the greatest ease to results which previously were most difficult of access; and improvements in notation may exercise the most powerful effects both in the simplification and accessibility of a subject. It rests with the worker in mathematics not only to explore new truths, but to devise the language by which they may be discovered and expressed; and the genius of a great mathematician displays itself no less in the notation he invents for deciphering his subject than in the results attained. … I have great faith in the power of well-chosen notation to simplify complicated theories and to bring remote ones near and I think it is safe to predict that the increased knowledge of principles and the resulting improvements in the symbolic language of mathematics will always enable us to grapple satisfactorily with the difficulties arising from the mere extent of the subject.

Knowing what we now know about living systems—how they replicate and how they mutate—we are beginning to know how to control their evolutionary futures. To a considerable extent we now do that with the plants we cultivate and the animals we domesticate. This is, in fact, a standard application of genetics today. We could even go further, for there is no reason why we cannot in the same way direct our own evolutionary futures. I wish to emphasize, however—and emphatically—that whether we should do this and, if so, how, are not questions science alone can answer. They are for society as a whole to think about. Scientists can say what the consequences might be, but they are not justified in going further except as responsible members of society.

Language is a guide to 'social reality.' Though language is not ordinarily thought of as essential interest to the students of social science, it powerfully conditions all our thinking about social problems and processes. Human beings do not live in the objective world alone, nor alone in the world of social activity as ordinarily understood, but are very much at the mercy of the particular language which has become the medium of expression for their society. It is quite an illusion to imagine that one adjusts to reality essentially without the use of language and that language is merely an incidental means of solving specific problems of communication or reflection. The fact of the matter is that the 'real world' is to a large extent unconsciously built up on the language habits of the group. No two languages are ever sufficiently similar to be considered as representing the same social reality. The worlds in which different societies live are distinct worlds, not merely the same world with different labels attached.

Let him [the author] be permitted also in all humility to add … that in consequence of the large arrears of algebraical and arithmetical speculations waiting in his mind their turn to be called into outward existence, he is driven to the alternative of leaving the fruits of his meditations to perish (as has been the fate of too many foregone theories, the still-born progeny of his brain, now forever resolved back again into the primordial matter of thought), or venturing to produce from time to time such imperfect sketches as the present, calculated to evoke the mental co-operation of his readers, in whom the algebraical instinct has been to some extent developed, rather than to satisfy the strict demands of rigorously systematic exposition.

Let him who so wishes take pleasure in boring us with all the wonders of nature: let one spend his life observing insects, another counting the tiny bones in the hearing membrane of certain fish, even in measuring, if you will, how far a flea can jump, not to mention so many other wretched objects of study; for myself, who am curious only about philosophy, who am sorry only not to be able to extend its horizons, active nature will always be my sole point of view; I love to see it from afar, in its breadth and its entirety, and not in specifics or in little details, which, although to some extent necessary in all the sciences, are generally the mark of little genius among those who devote themselves to them.

Let us now discuss the extent of the mathematical quality in Nature. According to the mechanistic scheme of physics or to its relativistic modification, one needs for the complete description of the universe not merely a complete system of equations of motion, but also a complete set of initial conditions, and it is only to the former of these that mathematical theories apply. The latter are considered to be not amenable to theoretical treatment and to be determinable only from observation.

Magnitude may be compared to the power output in kilowatts of a [radio] broadcasting station; local intensity, on the Mercalli or similar scale, is then comparable to the signal strength noted on a receiver at a given locality. Intensity, like signal strength, will generally fall off with distance from the source; it will also depend on local conditions at the point of observation, and to some extent on the conditions along the path from source to that point.

Man tries to make for himself in the fashion that suits him best a simplified and intelligible picture of the world; he then tries to some extent to substitute this cosmos of his for the world of experience, and thus to overcome it. This is what the painter, the poet, the speculative philosopher, and the natural scientist do, each in his own fashion. Each makes this cosmos and its construction the pivot of his emotional life, in order to find in this way the peace and security which he cannot find in the narrow whirlpool of personal experience.

Marxism is sociobiology without biology … Although Marxism was formulated as the enemy of ignorance and superstition, to the extent that it has become dogmatic it has faltered in that commitment and is now mortally threatened by the discoveries of human sociobiology.

Mathematics is a type of thought which seems ingrained in the human mind, which manifests itself to some extent with even the primitive races, and which is developed to a high degree with the growth of civilization. … A type of thought, a body of results, so essentially characteristic of the human mind, so little influenced by environment, so uniformly present in every civilization, is one of which no well-informed mind today can be ignorant.

Medals are great encouragement to young men and lead them to feel their work is of value, I remember how keenly I felt this when in the 1890s. I received the Darwin Medal and the Huxley Medal. When one is old, one wants no encouragement and one goes on with one's work to the extent of one’s power, because it has become habitual.

Men are weak now, and yet they transform the Earth’s surface. In millions of years their might will increase to the extent that they will change the surface of the Earth, its oceans, the atmosphere, and themselves. They will control the climate and the Solar System just as they control the Earth. They will travel beyond the limits of our planetary system; they will reach other Suns, and use their fresh energy instead of the energy of their dying luminary.

Modern tree communities in Amazonia are structured to an important extent by a long history of plant domestication by Amazonian peoples.

Nature, displayed in its full extent, presents us with an immense tableau, in which all the order of beings are each represented by a chain which sustains a continuous series of objects, so close and so similar that their difference would be difficult to define. This chain is not a simple thread which is only extended in length, it is a large web or rather a network, which, from interval to interval, casts branches to the side in order to unite with the networks of another order.

Nobody since Newton has been able to use geometrical methods to the same extent for the like purposes; and as we read the Principia we feel as when we are in an ancient armoury where the weapons are of gigantic size; and as we look at them we marvel what manner of man he was who could use as a weapon what we can scarcely lift as a burthen.

Nobody, certainly, will deny that the idea of the existence of an omnipotent, just, and omnibeneficent personal God is able to accord man solace, help, and guidance; also, by virtue of its simplicity it is accessible to the most undeveloped mind. But, on the other hand, there are decisive weaknesses attached to this idea in its elf, which have been painfully felt since the beginning of history. That is, if this being is omnipotent, then every occurrence, including every human action, every human thought, and every human feeling and aspiration is also His work; how is it possible to think of holding men responsible for their deeds and thoughts before such an almighty Being? In giving out punishment and rewards He would to a certain extent be passing judgment on Himself. How can this be combined with the goodness and righteousness ascribed to Him?

Obviously we biologists should fit our methods to our materials. An interesting response to this challenge has been employed particularly by persons who have entered biology from the physical sciences or who are distressed by the variability in biology; they focus their research on inbred strains of genetically homogeneous laboratory animals from which, to the maximum extent possible, variability has been eliminated. These biologists have changed the nature of the biological system to fit their methods. Such a bold and forthright solution is admirable, but it is not for me. Before I became a professional biologist, I was a boy naturalist, and I prefer a contrasting approach; to change the method to fit the system. This approach requires that one employ procedures which allow direct scientific utilization of the successful long-term evolutionary experiments which are documented by the fascinating diversity and variability of the species of animals which occupy the earth. This is easy to say and hard to do.

On the day of Cromwell’s death, when Newton was sixteen, a great storm raged all over England. He used to say, in his old age, that on that day he made his first purely scientific experiment. To ascertain the force of the wind, he first jumped with the wind and then against it; and, by comparing these distances with the extent of his own jump on a calm day, he was enabled to compute the force of the storm. When the wind blew thereafter, he used to say it was so many feet strong.

One of the endearing things about mathematicians is the extent to which they will go to avoid doing any real work.

One reason why mathematics enjoys special esteem, above all other sciences, is that its laws are absolutely certain and indisputable, while those of other sciences are to some extent debatable and in constant danger of being overthrown by newly discovered facts.

Organisms ... are directed and limited by their past. They must remain imperfect in their form and function, and to that extent unpredictable since they are not optimal machines. We cannot know their future with certainty, if only because a myriad of quirky functional shifts lie within the capacity of any feature, however well adapted to a present role.

Our situation on this earth seems strange. Every one of us appears here involuntarily and uninvited for a short stay, without knowing the whys and the wherefore. In our daily lives we only feel that man is here for the sake of others, for those whom we love and for many other beings whose fate is connected with our own. I am often worried at the thought that my life is based to such a large extent on the work of my fellow human beings and I am aware of my great indebtedness to them.

Perhaps there are somewhere in the infinite universe beings whose minds outrank our minds to the same extent as our minds surpass those of the insects. Perhaps there will once somewhere live beings who will look upon us with the same condescension as we look upon amoebae.

Philosophy stands in need of a science which shall determine the possibility, principles, and extent of human knowledge à priori.

Probably if half a kilogram [of radium] were in a bottle on that table it would kill us all. It would almost certainly destroy our sight and burn our skins to such an extent that we could not survive. The smallest bit placed on one’s arm would produce a blister which it would need months to heal.

Quarks appear to be without spatial extent and to lack a deeper structure: they have character without extension and are substance without inside.

Science and mathematics [are] much more compelling and exciting than the doctrines of pseudoscience, whose practitioners were condemned as early as the fifth century B.C. by the Ionian philosopher Heraclitus as “night walkers, magicians, priests of Bacchus, priestesses of the wine-vat, mystery-mongers.” But science is more intricate and subtle, reveals a much richer universe, and powerfully evokes our sense of wonder. And it has the additional and important virtue—to whatever extent the word has any meaning—of being true.

Science and technology multiply around us. To an increasing extent they dictate the languages in which we speak and think. Either we use those languages, or we remain mute.

Science cannot solve the ultimate mystery of nature. And that is because, in the last analysis, we ourselves are part of nature and therefore part of the mystery that we are trying to solve. Music and art are, to an extent, also attempts to solve or at least express the mystery. But to my mind the more we progress with either the more we are brought into harmony with all nature itself. And that is one of the great services of science to the individual.

Science emerges from the other progressive activities of man to the extent that new concepts arise from experiments and observations, and that the new concepts in turn lead to further experiments and observations.

Science has now been for a long time—and to an ever-increasing extent—a collective enterprise. Actually, new results are always, in fact, the work of specific individuals; but, save perhaps for rare exceptions, the value of any result depends on such a complex set of interrelations with past discoveries and possible future researches that even the mind of the inventor cannot embrace the whole.

Science has thus, most unexpectedly, placed in our hands a new power of great but unknown energy. It does not wake the winds from their caverns; nor give wings to water by the urgency of heat; nor drive to exhaustion the muscular power of animals; nor operate by complicated mechanism; nor summon any other form of gravitating force, but, by the simplest means—the mere contact of metallic surfaces of small extent, with feeble chemical agents, a power everywhere diffused through nature, but generally concealed from our senses, is mysteriously evolved, and by circulation in insulated wires, it is still more mysteriously augmented, a thousand and a thousand fold, until it breaks forth with incredible energy.

Science, in the immediate, produces knowledge and, indirectly, means of action. It leads to methodical action if definite goals are set up in advance. For the function of setting up goals and passing statements of value transcends its domain. While it is true that science, to the extent of its grasp of causative connections, may reach important conclusions as to the compatibility and incompatibility of goals and evaluations, the independent and fundamental definitions regarding goals and values remain beyond science’s reach.

Scientific findings do not threaten anyone (except to the extent that Homo sapiens may prove incapable of controlling what science makes possible). But what is critical to understand is that our species (or, for that matter, God) is not in the least diminished by the idea that we emerged thanks to the processes of evolution.

Scientific studies have strengthened my faith, strengthened it indeed to an extent that no study besides could have effected.

Suddenly there was an enormous explosion, like a violent volcano. The nuclear reactions had led to overheating in the underground burial grounds. The explosion poured radioactive dust and materials high up into the sky. It was just the wrong weather for such a tragedy. Strong winds blew the radioactive clouds hundreds of miles away. It was difficult to gauge the extent of the disaster immediately, and no evacuation plan was put into operation right away. Many villages and towns were only ordered to evacuate when the symptoms of radiation sickness were already quite apparent. Tens of thousands of people were affected, hundreds dying, though the real figures have never been made public. The large area, where the accident happened, is still considered dangerous and is closed to the public.

That hemisphere of the moon which faces us is better known than the earth itself; its vast desert plains have been surveyed to within a few acres; its mountains and craters have been measured to within a few yards; while on the earth's surface there are 30,000,000 square kilometres (sixty times the extent of France), upon which the foot of man has never trod, which the eye of man has never seen.

That no generally applicable law of the formulation and development of hybrids has yet been successfully formulated can hardly astonish anyone who is acquainted with the extent of the task and who can appreciate the difficulties with which experiments of this kind have to contend.

The absolute extent of land in the Archipelago is not greater than that contained by Western Europe from Hungary to Spain; but, owing to the manner in which the land is broken up and divided, the variety of its productions is rather in proportion to the immense surface over which the islands are spread, than to the quantity of land which they contain.

The artist and the scientist—and the physician, in a sense, is both—is a man who is presumed to be interested primarily in his work, not in its emoluments. He can do genuinely good work, indeed, only to the extent that he is so interested. The moment he begins habitually to engage in enterprises that offer him only profit he ceases to be either an artist or a scientist, and becomes a mere journeyman artisan.

The beauty of physics lies in the extent which seemingly complex and unrelated phenomena can be explained and correlated through a high level of abstraction by a set of laws which are amazing in their simplicity.

The best that Gauss has given us was likewise an exclusive production. If he had not created his geometry of surfaces, which served Riemann as a basis, it is scarcely conceivable that anyone else would have discovered it. I do not hesitate to confess that to a certain extent a similar pleasure may be found by absorbing ourselves in questions of pure geometry.

The days of the Mosaic creation are not to be strictly construed as implying the same length of time which is at present occupied by a single revolution of our globe, but PERIODS of a much longer extent.

The development of the nucleoplasm during ontogeny may be to some extent compared to an army composed of corps, which are made up of divisions, and these of brigades, and so on. The whole army may be taken to represent the nucleoplasm of the germ-cell: the earliest cell-division … may be represented by the separation of the two corps, similarly formed but with different duties: and the following cell­divisions by the successive detachment of divisions, brigades, regiments, battalions, companies, etc.; and as the groups become simpler so does their sphere of action become limited.

The energy of a covalent bond is largely the energy of resonance of two electrons between two atoms. The examination of the form of the resonance integral shows that the resonance energy increases in magnitude with increase in the overlapping of the two atomic orbitals involved in the formation of the bond, the word ‘overlapping” signifying the extent to which regions in space in which the two orbital wave functions have large values coincide... Consequently it is expected that of two orbitals in an atom the one which can overlap more with an orbital of another atom will form the stronger bond with that atom, and, moreover, the bond formed by a given orbital will tend to lie in that direction in which the orbital is concentrated.

The estimate we form of the intellectual capacity of our race, is founded on an examination of those productions which have resulted from the loftiest flights of individual genius, or from the accumulated labors of generations of men, by whose long-continued exertions a body of science has been raised up, surpassing in its extent the creative powers of any individual, and demanding for its development a length of time, to which no single life extends.