...Outer space, once a region of spirited international competition, is also a region of international cooperation. I realized this as early as 1959, when I attended an international conference on cosmic radiation in Moscow. At this conference, there were many differing views and differing methods of attack, but the problems were common ones to all of us and a unity of basic purpose was everywhere evident. Many of the papers presented there depended in an essential way upon others which had appeared originally in as many as three or four different languages. Surely science is one of the universal human activities.

[1665-08-31] Up, and after putting several things in order to my removal to Woolwich, the plague having a great increase this week beyond all expectation, of almost 2000 - making the general Bill 7000, odd 100 and the plague above 6000 .... Thus this month ends, with great sadness upon the public through the greateness of the plague, everywhere through the Kingdom almost. Every day sadder and sadder news of its increase. In the City died this week 7496; and all of them, 6102 of the plague. But it is feared that the true number of the dead this week is near 10000 - partly from the poor that cannot be taken notice of through the greatness of the number, and partly from the Quakers and others that will not have any bell ring for them. As to myself, I am very well; only, in fear of the plague, and as much of an Ague, by being forced to go early and late to Woolwich, and my family to lie there continually.

[About early aircraft:] We were ignorant, and we were ignorant of the fact that we were ignorant! This was ignorance squared, and it often led to disaster.

[At my secondary school] if you were very bright, you did classics; if you were pretty thick, you did woodwork; and if you were neither of those poles, you did science. The number of kids in my school who did science because they were excited by the notion of science was pretty small. You were allocated to those things, you weren’t asked. This was in the late 1930s/early 1940s … Science was seen as something more remote and less to do with everyday life.

[In early mill designs, from repeated handling, the flour was mixed with a] great quantity of dirt … from the dirty feet of every one who trampled in it, trailing it over the whole Mill and wasting much … [for] people did not even then like to eat dirt, if they could see it.

[In my early youth, walking with my father,] “See that bird?” he says. “It’s a Spencer’s warbler.” (I knew he didn’t know the real name.) “Well, in Italian, it’s a Chutto Lapittida. In Portuguese, it’s a Bom da Peida. In Chinese, it’s a Chung-long-tah, and in Japanese, it’s a Katano Tekeda. You can know the name of that bird in all the languages of the world, but when you’re finished, you’ll know absolutely nothing whatever about the bird. You’ll only know about humans in different places, and what they call the bird. So let’s look at the bird and see what it’s doing—that’s what counts.” (I learned very early the difference between knowing the name of something and knowing something.)

[The Book of Genesis is] [p]rofoundly interesting and indeed pathetic to me are those attempts of the opening mind of man to appease its hunger for a Cause. But the Book of Genesis has no voice in scientific questions. It is a poem, not a scientific treatise. In the former aspect it is for ever beautiful; in the latter it has been, and it will continue to be, purely obstructive and hurtful.'

[The] second fundamental rule of historical science may be thus simply expressed:—we should not wish to explain every thing. Historical tradition must never be abandoned in the philosophy of history—otherwise we lose all firm ground and footing. But historical tradition, ever so accurately conceived and carefully sifted, doth not always, especially in the early and primitive ages, bring with it a full and demonstrative certainty.

[There are only three ways to increase our chances against an asteroid aimed at Earth:] Find it early; find it early; find it early.

[About Sir Roderick Impey Murchison:] The enjoyments of elegant life you early chose to abandon, preferring to wander for many successive years over the rudest portions of Europe and Asia—regions new to Science—in the hope, happily realized, of winning new truths.
By a rare union of favourable circumstances, and of personal qualifications equally rare, you have thus been enabled to become the recognized Interpreter and Historian (not without illustrious aid) of the Silurian Period.

A fair number of people who go on to major in astronomy have decided on it certainly by the time they leave junior high, if not during junior high. I think it’s somewhat unusual that way. I think most children pick their field quite a bit later, but astronomy seems to catch early, and if it does, it sticks.

A new era of ocean exploration can yield discoveries that will help inform everything from critical medical advances to sustainable forms of energy. Consider that AZT, an early treatment for HIV, is derived from a Caribbean reef sponge, or that a great deal of energy—from offshore wind, to OTEC (ocean thermal energy conservation), to wind and wave energy—is yet untapped in our oceans.

About the year 1821, I undertook to superintend, for the Government, the construction of an engine for calculating and printing mathematical and astronomical tables. Early in the year 1833, a small portion of the machine was put together, and was found to perform its work with all the precision which had been anticipated. At that period circumstances, which I could not control, caused what I then considered a temporary suspension of its progress; and the Government, on whose decision the continuance or discontinuance of the work depended, have not yet communicated to me their wishes on the question.

All fossil anthropoids found hitherto have been known only from mandibular or maxillary fragments, so far as crania are concerned, and so the general appearance of the types they represented had been unknown; consequently, a condition of affairs where virtually the whole face and lower jaw, replete with teeth, together with the major portion of the brain pattern, have been preserved, constitutes a specimen of unusual value in fossil anthropoid discovery. Here, as in Homo rhodesiensis, Southern Africa has provided documents of higher primate evolution that are amongst the most complete extant. Apart from this evidential completeness, the specimen is of importance because it exhibits an extinct race of apes intermediate between living anthropoids and man ... Whether our present fossil is to be correlated with the discoveries made in India is not yet apparent; that question can only be solved by a careful comparison of the permanent molar teeth from both localities. It is obvious, meanwhile, that it represents a fossil group distinctly advanced beyond living anthropoids in those two dominantly human characters of facial and dental recession on one hand, and improved quality of the brain on the other. Unlike Pithecanthropus, it does not represent an ape-like man, a caricature of precocious hominid failure, but a creature well advanced beyond modern anthropoids in just those characters, facial and cerebral, which are to be anticipated in an extinct link between man and his simian ancestor. At the same time, it is equally evident that a creature with anthropoid brain capacity and lacking the distinctive, localised temporal expansions which appear to be concomitant with and necessary to articulate man, is no true man. It is therefore logically regarded as a man-like ape. I propose tentatively, then, that a new family of Homo-simidæ be created for the reception of the group of individuals which it represents, and that the first known species of the group be designated Australopithecus africanus, in commemoration, first, of the extreme southern and unexpected horizon of its discovery, and secondly, of the continent in which so many new and important discoveries connected with the early history of man have recently been made, thus vindicating the Darwinian claim that Africa would prove to be the cradle of mankind.

Although few expressions are more commonly used in writing about science than “science revolution,” there is a continuing debate as to the propriety of applying the concept and term “revolution” to scientific change. There is, furthermore, a wide difference of opinion as to what may constitute a revolution. And although almost all historians would agree that a genuine alteration of an exceptionally radical nature (the Scientific Revolution) occurred in the sciences at some time between the late fifteenth (or early sixteenth) century and the end of the seventeenth century, the question of exactly when this revolution occurred arouses as much scholarly disagreement as the cognate question of precisely what it was.

As there is no study which may be so advantageously entered upon with a less stock of preparatory knowledge than mathematics, so there is none in which a greater number of uneducated men have raised themselves, by their own exertions, to distinction and eminence. … Many of the intellectual defects which, in such cases, are commonly placed to the account of mathematical studies, ought to be ascribed to the want of a liberal education in early youth.

As, no matter what cunning system of checks we devise, we must in the end trust some one whom we do not check, but to whom we give unreserved confidence, so there is a point at which the understanding and mental processes must be taken as understood without further question or definition in words. And I should say that this point should be fixed pretty early in the discussion.

At the age of three I began to look around my grandfather’s library. My first knowledge of astronomy came from reading and looking at pictures at that time. By the time I was six I remember him buying books for me. … I think I was eight, he bought me a three-inch telescope on a brass mounting. It stood on a table. … So, as far back as I can remember, I had an early interest in science in general, astronomy in particular.

Because basic learning takes place so early—as…the classic musical South Pacific reminds us, “You've got to be taught before it’s too late, before you are six or seven or eight; you’ve got to be carefully taught,”—we must strengthen our pre-school program, especially Headstart, Kindergarten and Day Care.

Beware of old Linnaeus,
The Man of the Linden-tree,
So beautiful, bright and early
He brushed away the dews
He found the wicked wild-flowers
All courting there in twos.

But in nothing are swifts more singular than in their early retreat. They retire, as to the main body of them, by the tenth of August, and sometimes a few days sooner: and every straggler invariably withdraws by the twentieth, while their congeners, all of them, stay till the beginning of October; many of them all through that month, and some occasionally to the beginning of November. This early retreat is mysterious and wonderful, since that time is often the sweetest season in the year. But, what is more extraordinary, they begin to retire still earlier in the most southerly parts of Andalusia, where they can be no ways influenced by any defect of heat; or, as one might suppose, defect of food. Are they regulated in their motions with us by failure of food, or by a propensity to moulting, or by a disposition to rest after so rapid a life, or by what? This is one of those incidents in natural history that not only baffles our searches, but almost eludes our guesses!

But let your communication be Yea, yea; Nay, nay: for whatsoever is more than these cometh of evil.

By considering the embryological structure of man - the homologies which he presents with the lower animals - the rudiments which he retains - and the reversions to which he is liable, we can partly recall in imagination the former condition of our early progenitors; and we can approximately place them in their proper position in the zoological series. We thus learnt that man is descended from a hairy quadruped, furnished with a tail and pointed ears, probably arboreal in its habit, and an inhabitant of the Old World. This creature, if its whole structure had been examined by a naturalist, would have been classed among the Quadrumana, as surely as would be the common and still more ancient progenitor of the Old and New World monkeys.

By his very success in inventing labor-saving devices, modern man has manufactured an abyss of boredom that only the privileged classes in earlier civilizations have ever fathomed.

By the early 1960s Pauling had earned a reputation for being audacious, intuitive, charming, irreverent, self-promoting, self-reliant, self-involved to the point of arrogance and correct about almost everything.

Contrary to popular parlance, Darwin didn't discover evolution. He uncovered one (most would say the) essential mechanism by which it operates: natural selection. Even then, his brainstorm was incomplete until the Modern Synthesis of the early/mid-20th century when (among other things) the complementary role of genetic heredity was fully realized. Thousands upon thousands of studies have followed, providing millions of data points that support this understanding of how life on Earth has come to be as it is.

Cosmology is a science which has only a few observable facts to work with. The discovery of the cosmic microwave background radiation added one—the present radiation temperature of the universe. This, however, was a significant increase in our knowledge since it requires a cosmology with a source for the radiation at an early epoch and is a new probe of that epoch. More sensitive measurements of the background radiation in the future will allow us to discover additional facts about the universe.

Diseases can rarely be eliminated through early diagnosis or good treatment, but prevention can eliminate disease.

Don’t fight forces, use them.
[His motto of the early thirties.]

During the three years which I spent at Cambridge my time was wasted, as far as the academical studies were concerned…. I attempted mathematics, … but I got on very slowly. The work was repugnant to me, chiefly from my not being able to see any meaning in the early steps in algebra. This impatience was very foolish…

Earlier theories … were based on the hypothesis that all the matter in the universe was created in one big bang at a particular time in the remote past. [Coining the “big bang” expression.]

Early diagnosis of disease is the business of the general public even more than of the medical profession.

Early Greek astronomers, derived their first knowledge from the Egyptians, and these from the Chaldeans, among whom the science was studied, at a very early period. Their knowledge of astronomy, which gave their learned men the name of Magi, wise men, afterwards degenerated into astrology, or the art of consulting the position of the stars to foretel events—and hence sprung the silly occupation of sooth saying, for which the Chaldeans were noted to a proverb, in later ages.

Early in my school career, I turned out to be an incorrigible disciplinary problem. I could understand what the teacher was saying as fast as she could say it, I found time hanging heavy, so I would occasionally talk to my neighbor. That was my great crime, I talked in school.

Early in my school days a boy had a copy of the “Wonders of the World,” which I often read, and disputed with other boys about the veracity of some of the statements; and I believe that this book first gave me a wish to travel in remote countries, which was ultimately fulfilled by the voyage of the Beagle.

Early to bed and early to rise, makes a man healthy wealthy and wise.

Earthworms, though in appearance a small and despicable link in the chain of nature, yet, if lost, would make a lamentable chasm … worms seem to be the great promoters of vegetation, which would proceed but lamely without them.
[Showing an early awareness in ecology.]

Enthusiasm for the global-warming scare also ensures that heatwaves make headlines, while contrary symptoms, such as this winter’s billion-dollar loss of Californian crops to unusual frost, are relegated to the business pages. The early arrival of migrant birds in spring provides colourful evidence for a recent warming of the northern lands. But did anyone tell you that in east Antarctica the Adélie penguins and Cape petrels are turning up at their spring nesting sites around nine days later than they did 50 years ago? While sea-ice has diminished in the Arctic since 1978, it has grown by 8% in the Southern Ocean.

Even in populous districts, the practice of medicine is a lonely road which winds up-hill all the way and a man may easily go astray and never reach the Delectable Mountains unless he early finds those shepherd guides of whom Bunyan tells, Knowledge, Experience, Watchful, and Sincere.

Exercises in being obedient can not begin too early, and I have, during an almost daily observation of six years, discovered no harm from an early, consistent guiding of the germinating will, provided only this guiding be done with the greatest mildness and justice, as if the infant had already an insight into the benefits of obedience.

Expect an early death - it will keep you busier.

Felling a tree was possibly the original deed of appropriation of the natural earth by early mankind in Europe. Thousands of years ago,… man lifted a heavy flint tool and struck at the base of a tree. He may have wanted the tree for shelter and fuel, or possibly to make a bridge over a river or a path through a bog…. [E]ventually the tree crashed to the floor, and the first act in the slow possession of the land by its people was complete.

Fertilization of mammalian eggs is followed by successive cell divisions and progressive differentiation, first into the early embryo and subsequently into all of the cell types that make up the adult animal. Transfer of a single nucleus at a specific stage of development, to an enucleated unfertilized egg, provided an opportunity to investigate whether cellular differentiation to that stage involved irreversible genetic modification. The first offspring to develop from a differentiated cell were born after nuclear transfer from an embryo-derived cell line that had been induced to became quiescent. Using the same procedure, we now report the birth of live lambs from three new cell populations established from adult mammary gland, fetus and embryo. The fact that a lamb was derived from an adult cell confirms that differentiation of that cell did not involve the irreversible modification of genetic material required far development to term. The birth of lambs from differentiated fetal and adult cells also reinforces previous speculation that by inducing donor cells to became quiescent it will be possible to obtain normal development from a wide variety of differentiated cells.
[Co-author of paper announcing the cloned sheep, ‘Dolly’.]

For this we must make automatic and habitual, as early as possible, as many useful actions as we can, and guard against the growing into ways that are likely to be disadvantageous to us, as we should guard against the plague?

From the age of 13, I was attracted to physics and mathematics. My interest in these subjects derived mostly from popular science books that I read avidly. Early on I was fascinated by theoretical physics and determined to become a theoretical physicist. I had no real idea what that meant, but it seemed incredibly exciting to spend one's life attempting to find the secrets of the universe by using one's mind.

Getting up too early is a vice habitual in horned owls, stars, geese, and freight trains. Some hunters acquire it from geese, and some coffee pots from hunters.

He neither drank, smoked, nor rode a bicycle. Living frugally, saving his money, he died early, surrounded by greedy relatives. It was a great lesson to me.

Here is this vast, savage, howling mother of ours, Nature, lying all around, with such beauty, and such affection for her children, as the leopard; and yet we are so early weaned from her breast to society, to that, culture which is exclusively an interaction of man on man.

Historically [chemistry] arose from a constellation of interests: the empirically based technologies of early metallurgists, brewers, dyers, tanners, calciners and pharmacists; the speculative Greek philosphers' concern whether brute matter was invariant or transformable; the alchemists' real or symbolic attempts to achieve the transmutation of base metals into gold; and the iatrochemists' interst in the chemistry and pathology of animal and human functions. Partly because of the sheer complexity of chemical phenomena, the absence of criteria and standards of purity, and uncertainty over the definition of elements ... but above all because of the lack of a concept of the gaseous state of matter, chemistry remained a rambling, puzzling and chaotic area of natural philosophy until the middle of the eighteenth century.

I believe that the useful methods of mathematics are easily to be learned by quite young persons, just as languages are easily learned in youth. What a wondrous philosophy and history underlie the use of almost every word in every language—yet the child learns to use the word unconsciously. No doubt when such a word was first invented it was studied over and lectured upon, just as one might lecture now upon the idea of a rate, or the use of Cartesian co-ordinates, and we may depend upon it that children of the future will use the idea of the calculus, and use squared paper as readily as they now cipher. … When Egyptian and Chaldean philosophers spent years in difficult calculations, which would now be thought easy by young children, doubtless they had the same notions of the depth of their knowledge that Sir William Thomson might now have of his. How is it, then, that Thomson gained his immense knowledge in the time taken by a Chaldean philosopher to acquire a simple knowledge of arithmetic? The reason is plain. Thomson, when a child, was taught in a few years more than all that was known three thousand years ago of the properties of numbers. When it is found essential to a boy’s future that machinery should be given to his brain, it is given to him; he is taught to use it, and his bright memory makes the use of it a second nature to him; but it is not till after-life that he makes a close investigation of what there actually is in his brain which has enabled him to do so much. It is taken because the child has much faith. In after years he will accept nothing without careful consideration. The machinery given to the brain of children is getting more and more complicated as time goes on; but there is really no reason why it should not be taken in as early, and used as readily, as were the axioms of childish education in ancient Chaldea.

I can remember … starting to gather all sorts of things like rocks and beetles when I was about nine years old. There was no parental encouragement—nor discouragement either—nor any outside influence that I can remember in these early stages. By about the age of twelve, I had settled pretty definitely on butterflies, largely I think because the rocks around my home were limited to limestone, while the butterflies were varied, exciting, and fairly easy to preserve with household moth-balls. … I was fourteen, I remember, when … I decided to be scientific, caught in some net of emulation, and resolutely threw away all of my “childish” specimens, mounted haphazard on “common pins” and without “proper labels.” The purge cost me a great inward struggle, still one of my most vivid memories, and must have been forced by a conflict between a love of my specimens and a love for orderliness, for having everything just exactly right according to what happened to be my current standards.

I cannot find anything showing early aptitude for acquiring languages; but that he [Clifford] had it and was fond of exercising it in later life is certain. One practical reason for it was the desire of being able to read mathematical papers in foreign journals; but this would not account for his taking up Spanish, of which he acquired a competent knowledge in the course of a tour to the Pyrenees. When he was at Algiers in 1876 he began Arabic, and made progress enough to follow in a general way a course of lessons given in that language. He read modern Greek fluently, and at one time he was furious about Sanskrit. He even spent some time on hieroglyphics. A new language is a riddle before it is conquered, a power in the hand afterwards: to Clifford every riddle was a challenge, and every chance of new power a divine opportunity to be seized. Hence he was likewise interested in the various modes of conveying and expressing language invented for special purposes, such as the Morse alphabet and shorthand. … I have forgotten to mention his command of French and German, the former of which he knew very well, and the latter quite sufficiently; …

I didn’t really decide that I wanted to be an astronaut for sure until the end of college. But even in elementary school and junior high, I was very interested in space and in the space program. I had both male and female heroes. One was a high school science teacher who was very important in encouraging me to pursue science. Because I was a tennis player, Billie Jean King was a hero of mine. And the early astronauts, John Glenn and Neil Armstrong, were heroes of mine as well.

I don't grow up. In me is the small child of my early days.

I experimented with all possible maneuvers—loops, somersaults and barrel rolls. I stood upside down on one finger and burst out laughing, a shrill, distorted laugh. Nothing I did altered the automatic rhythm of the air. Delivered from gravity and buoyancy, I flew around in space.
Describing his early test (1943) in the Mediterranean Sea of the Aqua-Lung he co-invented.

I found out at an early age that science is a haven for the timid, the freaks, the misfits. That is more true perhaps for the past than now. If you were a student in Göttingen in the 1920s and went to the seminar “Structure of Matter” which was under the joint auspices of David Hilbert and Max Born, you could well imagine that you were in a madhouse as you walked in. Every one of the persons there was obviously some kind of a severe case. The least you could do was put on some kind of a stutter. Robert Oppenheimer as a graduate student found it expedient to develop a very elegant kind of stutter, the "njum-njum-njum" technique. Thus, if you were an oddball you felt at home.

I grew up in Brooklyn, New York … a city neighborhood that included houses, lampposts, walls, and bushes. But with an early bedtime in the winter, I could look out my window and see the stars, and the stars were not like anything else in my neighborhood. [At age 5] I didn’t know what they were.
[At age 9] my mother … said to me, “You have a library card now, and you know how to read. Take the streetcar to the library and get a book on stars.” … I stepped up to the big librarian and asked for a book on stars. … I sat down and found out the answer, which was something really stunning.
I found out that the stars are glowing balls of gas. I also found out that the Sun is a star but really close and that the stars are all suns except really far away I didn’t know any physics or mathematics at that time, but I could imagine how far you’d have to move the Sun away from us till it was only as bright as a star. It was in that library, reading that book, that the scale of the universe opened up to me. There was something beautiful about it.
At that young age, I already knew that I’d be very happy if I could devote my life to finding out more about the stars and the planets that go around them. And it’s been my great good fortune to do just that.

I never got tired of watching the radar echo from an aircraft as it first appeared as a tiny blip in the noise on the cathode-ray tube, and then grew slowly into a big deflection as the aircraft came nearer. This strange new power to “see” things at great distances, through clouds or darkness, was a magical extension of our senses. It gave me the same thrill that I felt in the early days of radio when I first heard a voice coming out of a horn...

I saw a horrible brown heap on the floor in the corner, which, but for previous experience in this dismal wise, I might not have suspected to be “the bed.” There was something thrown upon it and I asked what it was. “’Tis the poor craythur that stays here, sur; and ’tis very bad she is, ’tis very bad she’s been this long time, and ’tis better she’ll never be, and ’tis slape she doos all day, and ’tis wake she doos all night, and ‘tis the lead, Sur.” “The what?” “The lead, Sur. Sure, ’tis the lead-mills, where women gets took on at eighteen pence a day, Sur, when they makes application early enough, and is lucky and wanted, and ’tis lead-pisoned she is, Sur, and some of them gits lead-pisoned soon and some of them gets lead-pisoned later, and some but not many, niver, and ’tis all according to the constitooshun, Sur, and some constitooshuns is strong, and some is weak, and her constitooshun is lead-pisoned, bad as can be, Sur, and her brain is coming out at her ear, and it hurts her dreadful, and that’s what it is and niver no more and niver so less, Sur.”

I shall consider this paper an essay in geopoetry. In order not to travel any further into the realm of fantasy than is absolutely necessary I shall hold as closely as possibly to a uniformitarian approach; even so, at least one great catastrophe will be required early in the Earth's history.

I should rejoice to see … Euclid honourably shelved or buried “deeper than did ever plummet sound” out of the schoolboys’ reach; morphology introduced into the elements of algebra; projection, correlation, and motion accepted as aids to geometry; the mind of the student quickened and elevated and his faith awakened by early initiation into the ruling ideas of polarity, continuity, infinity, and familiarization with the doctrines of the imaginary and inconceivable.

I stand almost with the others. They believe the world was made for man, I believe it likely that it was made for man; they think there is proof, astronomical mainly, that it was made for man, I think there is evidence only, not proof, that it was made for him. It is too early, yet, to arrange the verdict, the returns are not all in. When they are all in, I think that they will show that the world was made for man; but we must not hurry, we must patiently wait till they are all in.

I went to the trash pile at Tuskegee Institute and started my laboratory with bottles, old fruit jars and any other thing I found I could use. … [The early efforts were] worked out almost wholly on top of my flat topped writing desk and with teacups, glasses, bottles and reagents I made myself.

I write to discover what I think. After all, the bars aren’t open that early.

I wrote a great deal during the next ten [early] years,but very little of any importance; there are not more than four or five papers which I can still remember with some satisfaction.

If a solution fails to appear … and yet we feel success is just around the corner, try resting for a while. … Like the early morning frost, this intellectual refreshment withers the parasitic and nasty vegetation that smothers the good seed. Bursting forth at last is the flower of truth.

If diphtheria is a disease caused by a microorganism, it is essential that three postulates be fulfilled. The fulfilment of these postulates is necessary in order to demonstrate strictly the parasitic nature of a disease:
1) The organism must be shown to be constantly present in characteristic form and arrangement in the diseased tissue.
2) The organism which, from its behaviour appears to be responsible for the disease, must be isolated and grown in pure culture.
3) The pure culture must be shown to induce the disease experimentally.
An early statement of Koch's postulates.

If faith cannot be reconciled with rational thinking, it has to be eliminated as an anachronistic remnant of earlier stages of culture and replaced by science dealing with facts and theories which are intelligible and can be validated.

If gold medals and prizes were awarded to institutions instead of individuals, the Peter Bent Brigham Hospital of 30 years ago would have qualified. The ruling board and administrative structure of that hospital did not falter in their support of the quixotic objective of treating end-stage renal disease despite a long list of tragic failures that resulted from these early efforts.

If the resident zoologist of Galaxy X had visited the earth 5 million years ago while making his inventory of inhabited planets in the universe, he would surely have corrected his earlier report that apes showed more promise than Old World monkeys and noted that monkeys had overcome an original disadvantage to gain domination among primates. (He will confirm this statement after his visit next year–but also add a footnote that one species from the ape bush has enjoyed an unusual and unexpected flowering, thus demanding closer monitoring.)

If there’s more than one way to do a job and one of those ways will end in disaster, then somebody will do it that way.
[Early statement of what became known as Murphy's Law.]

If you advertise to tell lies, it will ruin you, but if you advertise to tell the public the truth, and particularly to give information, it will bring you success. I learned early that to tell a man how best to use tires, and to make him want them, was far better than trying to tell him that your tire is the best in the world. If you believe that yours is, let your customer find it out.

Immense deposits of kimmeridge clay, containing the oil-bearing bands or seams, stretch across England from Dorsetshire to Lincolnshire. [An early political recognition of the native resource. The Geological Survey had identified the inflammable oil shale in reports since at least 1888.]

In 1905, a physicist measuring the thermal conductivity of copper would have faced, unknowingly, a very small systematic error due to the heating of his equipment and sample by the absorption of cosmic rays, then unknown to physics. In early 1946, an opinion poller, studying Japanese opinion as to who won the war, would have faced a very small systematic error due to the neglect of the 17 Japanese holdouts, who were discovered later north of Saipan. These cases are entirely parallel. Social, biological and physical scientists all need to remember that they have the same problems, the main difference being the decimal place in which they appear.

In a sense, genetics grew up as an orphan. In the beginning botanists and zoologists were often indifferent and sometimes hostile toward it. “Genetics deals only with superficial characters”, it was often said. Biochemists likewise paid it little heed in its early days. They, especially medical biochemists, knew of Garrod’s inborn errors of metabolism and no doubt appreciated them in the biochemical sense and as diseases; but the biological world was inadequately prepared to appreciate fully the significance of his investigations and his thinking. Geneticists, it should be said, tended to be preoccupied mainly with the mechanisms by which genetic material is transmitted from one generation to, the next.

In early life I had felt a strong desire to devote myself to the experimental study of nature; and, happening to see a glass containing some camphor, portions of which had been caused to condense in very beautiful crystals on the illuminated side, I was induced to read everything I could obtain respecting the chemical and mechanical influences of light, adhesion, and capillary attraction.

In early times, medicine was an art, which took its place at the side of poetry and painting; to-day, they try to make a science of it, placing it beside mathematics, astronomy, and physics.

In early times, when the knowledge of nature was small, little attempt was made to divide science into parts, and men of science did not specialize. Aristotle was a master of all science known in his day, and wrote indifferently treatises on physics or animals. As increasing knowledge made it impossible for any one man to grasp all scientific subjects, lines of division were drawn for convenience of study and of teaching. Besides the broad distinction into physical and biological science, minute subdivisions arose, and, at a certain stage of development, much attention was, given to methods of classification, and much emphasis laid on the results, which were thought to have a significance beyond that of the mere convenience of mankind.
But we have reached the stage when the different streams of knowledge, followed by the different sciences, are coalescing, and the artificial barriers raised by calling those sciences by different names are breaking down. Geology uses the methods and data of physics, chemistry and biology; no one can say whether the science of radioactivity is to be classed as chemistry or physics, or whether sociology is properly grouped with biology or economics. Indeed, it is often just where this coalescence of two subjects occurs, when some connecting channel between them is opened suddenly, that the most striking advances in knowledge take place. The accumulated experience of one department of science, and the special methods which have been developed to deal with its problems, become suddenly available in the domain of another department, and many questions insoluble before may find answers in the new light cast upon them. Such considerations show us that science is in reality one, though we may agree to look on it now from one side and now from another as we approach it from the standpoint of physics, physiology or psychology.

In Japan, an exceptional dexterity that comes from eating with chopsticks … is especially useful in micro-assembly. (This … brings smiles from my colleagues, but I stand by it. Much of modern assembly is fine tweezer work, and nothing prepares for it better than eating with chopsticks from early childhood.)

In the beginning there was an explosion. Not an explosion like those familiar on earth, starting from a definite center and spreading out to engulf more and more of the circumambient air, but an explosion which occurred simultaneously everywhere, filling all space from the beginning, with every particle of matter rushing apart from every other particle. ‘All space’ in this context may mean either all of an infinite universe, or all of a finite universe which curves back on itself like the surface of a sphere. Neither possibility is easy to comprehend, but this will not get in our way; it matters hardly at all in the early universe whether space is finite or infinite. At about one-hundredth of a second, the earliest time about which we can speak with any confidence, the temperature of the universe was about a hundred thousand million (10¹¹) degrees Centigrade. This is much hotter than in the center of even the hottest star, so hot, in fact, that none of the components of ordinary matter, molecules, or atoms, or even the nuclei of atoms, could have held together. Instead, the matter rushing apart in this explosion consisted of various types of the so-called elementary particles, which are the subject of modern high­energy nuclear physics.

In the days when geology was young, now some two hundred years ago, it found a careful foster-mother in theology, who watched over its early growth with anxious solicitude, and stored its receptive mind with the most beautiful stories, which the young science never tired of transforming into curious fancies of its own, which it usually styled “theories of the earth.”

In the early days of dealing with climate change, I wouldn’t go out on a limb one way or another, because I don’t have the qualifications there. But I do have the qualifications to measure the scientific community and see what the consensus is about climate change. I remember the moment when I suddenly thought it was incontrovertible. There was a lecture given by a distinguished American expert in atmospheric science and he showed a series of graphs about the temperature changes in the upper atmosphere. He plotted time against population growth and industrialisation. It was incontrovertible, and once you think it’s really totally incontrovertible, then you have a responsibility to say so.

In the early days of telephone engineering, the mere sending of a message was so much of a miracle that nobody asked how it should be sent.

In the early seventies my mother [Mary Leakey] returned to Laetoli, a site in Tanzania that my parents had discovered in the thirties. In 1976, she discovered footprints of ancient hominids. These three-and-a-half-million- year-old footprints provide evidence of bipedality.

In the first papers concerning the aetiology of tuberculosis I have already indicated the dangers arising from the spread of the bacilli-containing excretions of consumptives, and have urged moreover that prophylactic measures should be taken against the contagious disease. But my words have been unheeded. It was still too early, and because of this they still could not meet with full understanding. It shared the fate of so many similar cases in medicine, where a long time has also been necessary before old prejudices were overcome and the new facts were acknowledged to be correct by the physicians.

In the great debates of early-nineteenth century geology, catastrophists followed the stereotypical method of objective science-empirical literalism. They believed what they saw, interpolated nothing, and read the record of the rocks directly.

In the history of physics, there have been three great revolutions in thought that first seemed absurd yet proved to be true. The first proposed that the earth, instead of being stationary, was moving around at a great and variable speed in a universe that is much bigger than it appears to our immediate perception. That proposal, I believe, was first made by Aristarchos two millenia ago ... Remarkably enough, the name Aristarchos in Greek means best beginning.
[The next two revolutions occurred ... in the early part of the twentieth century: the theory of relativity and the science of quantum mechanics...]

In the year of our Lord 729, two comets appeared around the sun, striking terror into all who saw them. One comet rose early and preceded the sun, while the other followed the setting sun at evening, seeming to portend awful calamity to east and west alike. Or else, since one comet was the precursor of day and the other of night, they indicated that mankind was menaced by evils at both times. They appeared in the month of January, and remained visible for about a fortnight, pointing their fiery torches northward as though to set the welkin aflame. At this time, a swarm of Saracens ravaged Gaul with horrible slaughter; … Both the outset and course of Ceolwulfs reign were filled by so many grave disturbances that it is quite impossible to know what to write about them or what the outcome will be.

In those early days, the Chief Engineer was almost always the Chief Pilot as well. This had the automatic result of eliminating poor engineering very early in aviation.

Injustice or oppression in the next street...or any spot inhabited by men was a personal affront to Thomas Addis and his name, from its early alphabetical place, was conspicuous on lists of sponsors of scores of organizations fighting for democracy and against fascism. He worked on more committees than could reasonably have been expected of so busy a man... Tom Addis was happy to have a hand in bringing to the organization of society some of the logic of science and to further that understanding and to promote that democracy which are the only enduring foundations of human dignity.

Intelligence, in diapers, is invisible. And when it matures, out the window it flies. We have to pounce on it earlier.

It has the property of detonating very violently in certain circumstances. On one occasion a small amount of ether solution of pyroglycerin condensed in a glass bowl. ... When the bowl was heated over a spirit lamp, an extremely violent explosion occurred, which shattered it into small fragments. On another occasion a drop was heated in a test-tube, and exploded with such violence that the glass splinters cut deep into my face and hands, and hurt other people who were standing some distance off in the room.
[Describing early experiments on his discovery of nitroglycerin.]

It is a remarkable illustration of the ranging power of the human intellect that a principle first detected in connection with the clumsy puffing of the early steam engines should be found to apply to the whole world, and possibly, even to the whole cosmic universe.

It is above all the duty of the methodical text-book to adapt itself to the pupil’s power of comprehension, only challenging his higher efforts with the increasing development of his imagination, his logical power and the ability of abstraction. This indeed constitutes a test of the art of teaching, it is here where pedagogic tact becomes manifest. In reference to the axioms, caution is necessary. It should be pointed out comparatively early, in how far the mathematical body differs from the material body. Furthermore, since mathematical bodies are really portions of space, this space is to be conceived as mathematical space and to be clearly distinguished from real or physical space. Gradually the student will become conscious that the portion of the real space which lies beyond the visible stellar universe is not cognizable through the senses, that we know nothing of its properties and consequently have no basis for judgments concerning it. Mathematical space, on the other hand, may be subjected to conditions, for instance, we may condition its properties at infinity, and these conditions constitute the axioms, say the Euclidean axioms. But every student will require years before the conviction of the truth of this last statement will force itself upon him.

It is as if Cleopatra fell off her barge in 40 BC and hasn't hit the water yet.
[Illustrating how strange the behaviour of kaon particles, when first found in cosmic rays, which lived without predicted decay for a surprisingly long time—seemingly postponed a million billion times longer than early theory expected.]

It is clear, from these considerations, that the three methods of classifying mankind—that according to physical characters, according to language, and according to culture—all reflect the historical development of races from different standpoints; and that the results of the three classifications are not comparable, because the historical facts do not affect the three classes of phenomena equally. A consideration of all these classes of facts is needed when we endeavour to reconstruct the early history of the races of mankind.

It is even harder to realize that this present universe has evolved from an unspeakably unfamiliar early condition, and faces a future extinction of endless cold or intolerable heat. The more the universe seems comprehensible, the more it seems pointless.

It is often assumed that because the young child is not competent to study geometry systematically he need be taught nothing geometrical; that because it would be foolish to present to him physics and mechanics as sciences it is useless to present to him any physical or mechanical principles.
An error of like origin, which has wrought incalculable mischief, denies to the scholar the use of the symbols and methods of algebra in connection with his early essays in numbers because, forsooth, he is not as yet capable of mastering quadratics! … The whole infant generation, wrestling with arithmetic, seek for a sign and groan and travail together in pain for the want of it; but no sign is given them save the sign of the prophet Jonah, the withered gourd, fruitless endeavor, wasted strength.

It is only in mathematics, and to some extent in poetry, that originality may be attained at an early age, but even then it is very rare (Newton and Keats are examples), and it is not notable until adolescence is completed.

It is the man of science, eager to have his every opinion regenerated, his every idea rationalised, by drinking at the fountain of fact, and devoting all the energies of his life to the cult of truth, not as he understands it, but as he does not understand it, that ought properly to be called a philosopher. To an earlier age knowledge was power—merely that and nothing more—to us it is life and the summum bonum.

It is unquestionably no slight advantage to be placed, at that early stage of life, when the mind collects its facts with greatest avidity, and the curiosity is most active, in localities where there is much to attract observation that has, escaped the notice of others. … I…was born on the Old Red Sandstone [of Scotland].

It is well known that theoretical physicists cannot handle experimental equipment; it breaks whenever they touch it. Pauli was such a good theoretical physicist that something usually broke in the lab whenever he merely stepped across the threshold. A mysterious event that did not seem at first to be connected with Pauli's presence once occurred in Professor J. Franck's laboratory in Göttingen. Early one afternoon, without apparent cause, a complicated apparatus for the study of atomic phenomena collapsed. Franck wrote humorously about this to Pauli at his Zürich address and, after some delay, received an answer in an envelope with a Danish stamp. Pauli wrote that he had gone to visit Bohr and at the time of the mishap in Franck's laboratory his train was stopped for a few minutes at the Göttingen railroad station. You may believe this anecdote or not, but there are many other observations concerning the reality of the Pauli Effect!

It was eerie. I saw myself in that machine. I never thought my work would come to this.
Upon seeing a distorted image of his face, reflected on the inside cylindrical surface of the bore while inside an MRI (magnetic-resonance-imaging) machine—a device made possible by his early physical researches on nuclear magnetic resonance (1938).

It was his [Leibnitz’s] love of method and order, and the conviction that such order and harmony existed in the real world, and that our success in understanding it depended upon the degree and order which we could attain in our own thoughts, that originally was probably nothing more than a habit which by degrees grew into a formal rule. This habit was acquired by early occupation with legal and mathematical questions. We have seen how the theory of combinations and arrangements of elements had a special interest for him. We also saw how mathematical calculations served him as a type and model of clear and orderly reasoning, and how he tried to introduce method and system into logical discussions, by reducing to a small number of terms the multitude of compound notions he had to deal with. This tendency increased in strength, and even in those early years he elaborated the idea of a general arithmetic, with a universal language of symbols, or a characteristic which would be applicable to all reasoning processes, and reduce philosophical investigations to that simplicity and certainty which the use of algebraic symbols had introduced into mathematics.
A mental attitude such as this is always highly favorable for mathematical as well as for philosophical investigations. Wherever progress depends upon precision and clearness of thought, and wherever such can be gained by reducing a variety of investigations to a general method, by bringing a multitude of notions under a common term or symbol, it proves inestimable. It necessarily imports the special qualities of number—viz., their continuity, infinity and infinite divisibility—like mathematical quantities—and destroys the notion that irreconcilable contrasts exist in nature, or gaps which cannot be bridged over. Thus, in his letter to Arnaud, Leibnitz expresses it as his opinion that geometry, or the philosophy of space, forms a step to the philosophy of motion—i.e., of corporeal things—and the philosophy of motion a step to the philosophy of mind.

It was to Hofmeister, working as a young man, an amateur and enthusiast, in the early morning hours of summer months, before business, at Leipzig in the years before 1851, that the vision first appeared of a common type of Life-Cycle, running through Mosses and Ferns to Gymnosperms and Flowering Plants, linking the whole series in one scheme of reproduction and life-history.

Late children, early orphans.

Let the sun never set or rise on a small bowel obstruction.
Adage expressing urgency for early operation to avoid possible fatality.

Man has generally been preoccupied with obtaining as much “production” from the landscape as possible, by developing and maintaining early successional types of ecosystems, usually monocultures. But, of course, man does not live by food and fiber alone; he also needs a balanced CO2-O2 atmosphere, the climactic buffer provided by oceans and masses of vegetation, and clean (that is, unproductive) water for cultural and industrial uses. Many essential life-cycle resources, not to mention recreational and esthetic needs, are best provided man by the less 'productive' landscapes. In other words, the landscape is not just a supply depot but is also the oikos—the home—in which we must live.

Mathematics is distinguished from all other sciences except only ethics, in standing in no need of ethics. Every other science, even logic—logic, especially—is in its early stages in danger of evaporating into airy nothingness, degenerating, as the Germans say, into an anachrioid [?] film, spun from the stuff that dreams are made of. There is no such danger for pure mathematics; for that is precisely what mathematics ought to be.

Mathematics, from the earliest times to which the history of human reason can reach, has followed, among that wonderful people of the Greeks, the safe way of science. But it must not be supposed that it was as easy for mathematics as for logic, in which reason is concerned with itself alone, to find, or rather to make for itself that royal road. I believe, on the contrary, that there was a long period of tentative work (chiefly still among the Egyptians), and that the change is to be ascribed to a revolution, produced by the happy thought of a single man, whose experiments pointed unmistakably to the path that had to be followed, and opened and traced out for the most distant times the safe way of a science. The history of that intellectual revolution, which was far more important than the passage round the celebrated Cape of Good Hope, and the name of its fortunate author, have not been preserved to us. … A new light flashed on the first man who demonstrated the properties of the isosceles triangle (whether his name was Thales or any other name), for he found that he had not to investigate what he saw in the figure, or the mere concepts of that figure, and thus to learn its properties; but that he had to produce (by construction) what he had himself, according to concepts a priori, placed into that figure and represented in it, so that, in order to know anything with certainty a priori, he must not attribute to that figure anything beyond what necessarily follows from what he has himself placed into it, in accordance with the concept.

My earliest impressions of wildlife and its pursuit retain a vivid sharpness of form, color, and atmosphere that half a century of professional wildlife experience has failed to obliterate or improve on.

My eureka moment was in the dead of night, the early hours of the morning, on a cold, cold night, and my feet were so cold, they were aching. But when the result poured out of the charts, you just forget all that. You realize instantly how significant this is—what it is you’ve really landed on—and it’s great!
[About her discovery of the first pulsar radio signals.]

My father’s collection of fossils was practically unnamed, but the appearance of Phillips’ book [Geology of the Yorkshire Coast], in which most of our specimens were figured, enabled us to remedy this defect. Every evening was devoted by us to accomplishing the work. This was my first introduction to true scientific study. … Phillips’ accurate volume initiated an entirely new order of things. Many a time did I mourn over the publication of this book, and the consequences immediately resulting from it. Instead of indulging in the games and idleness to which most lads are prone, my evenings throughout a long winter were devoted to the detested labour of naming these miserable stones. Such is the short-sightedness of boyhood. Pursuing this uncongenial work gave me in my thirteenth year a thorough practical familiarity with the palaeontological treasures of Eastern Yorkshire. This early acquisition happily moulded the entire course of my future life.

My interest in Science had many roots. Some came from my mother … while I was in my early teens. She fell in love with science,… [from] classes on the Foundations of Physical Science. … I was infected by [her] professor second hand, through hundreds of hours of conversations at my mother’s knees. It was from my mother that I first learned of Archimedes, Leonardo da Vinci, Galileo, Kepler, Newton, and Darwin. We spent hours together collecting single-celled organisms from a local pond and watching them with a microscope.

My interest in the sciences started with mathematics in the very beginning, and later with chemistry in early high school and the proverbial home chemistry set.

My mother, my dad and I left Cuba when I was two [January, 1959]. Castro had taken control by then, and life for many ordinary people had become very difficult. My dad had worked [as a personal bodyguard for the wife of Cuban president Batista], so he was a marked man. We moved to Miami, which is about as close to Cuba as you can get without being there. It’s a Cuba-centric society. I think a lot of Cubans moved to the US thinking everything would be perfect. Personally, I have to say that those early years were not particularly happy. A lot of people didn’t want us around, and I can remember seeing signs that said: “No children. No pets. No Cubans.” Things were not made easier by the fact that Dad had begun working for the US government. At the time he couldn’t really tell us what he was doing, because it was some sort of top-secret operation. He just said he wanted to fight against what was happening back at home. [Estefan’s father was one of the many Cuban exiles taking part in the ill-fated, anti-Castro Bay of Pigs invasion to overthrow dictator Fidel Castro.] One night, Dad disappeared. I think he was so worried about telling my mother he was going that he just left her a note. There were rumors something was happening back home, but we didn’t really know where Dad had gone. It was a scary time for many Cubans. A lot of men were involved—lots of families were left without sons and fathers. By the time we found out what my dad had been doing, the attempted coup had taken place, on April 17, 1961. Initially he’d been training in Central America, but after the coup attempt he was captured and spent the next two years as a political prisoner in Cuba. That was probably the worst time for my mother and me. Not knowing what was going to happen to Dad. I was only a kid, but I had worked out where my dad was. My mother was trying to keep it a secret, so she used to tell me Dad was on a farm. Of course, I thought that she didn’t know what had really happened to him, so I used to keep up the pretense that Dad really was working on a farm. We used to do this whole pretending thing every day, trying to protect each other. Those two years had a terrible effect on my mother. She was very nervous, just going from church to church. Always carrying her rosary beads, praying her little heart out. She had her religion, and I had my music. Music was in our family. My mother was a singer, and on my father’s side there was a violinist and a pianist. My grandmother was a poet.