Phosphate Quotes (6 quotes)
A time will come, when fields will be manured with a solution of glass (silicate of potash), with the ashes of burnt straw, and with the salts of phosphoric acid, prepared in chemical manufactories, exactly as at present medicines are given for fever and goitre.
Agricultural Chemistry (1847), 4th edn., 186.
Conclusion: Big helix in several chains, phosphates on outside, phosphate-phosphate inter-helical bonds disrupted by water. Phosphate links available to proteins.
Underlined in typewritten lecture notes, with handwritten annotations, as report (7 Feb 1952) on 'Colloquium November 1951'. As given in Anne Sayre, Rosalind Franklin and DNA (1975), 128.
Every arsenate has its corresponding phosphate, composed according to the same proportions, combined with the same amount of water of crystallization, and endowed with the same physical properties: in fact, the two series of salts differ in no respect, except that the radical of the acid in one series in phosphorus, while in the other it is arsenic.
The experimental clue he used forming his law of isomerism. Originally published in 'Om Förhållandet emellan chemiska sammansättningen och krystallformen hos Arseniksyrade och Phosphorsyrade Salter', (On the Relation between the Chemical Composition and Crystal Form of Salts of Arsenic and Phosphoric Acids), Kungliga Svenska vetenskapsakademiens handlingar (1821), 4. Translation as shown in Joseph William Mellor, A Comprehensive Treatise on Inorganic and Theoretical Chemistry (1922), Vol. 1, 652. A very similar translation (“the same physical properties” is replaced with “nearly equal solubilities in water and acids”) is in F. Szabadváry article on 'Eilhard Mitscherlich' in Charles Coulston Gillispie (ed.), Dictionary of Scientific Biography (1974), Vol. 9, 424; perhaps from J.R. Partington, A History of Chemistry, Vol. 4 (1964), 210.
Of the nucleosides from deoxyribonucleic acids, all that was known with any certainty [in the 1940s] was that they were 2-deoxy-D-ribosides of the bases adenine, guanine, thymine and cytosine and it was assumed that they were structurally analogous to the ribonucleosides. The chemistry of the nucleotides—the phosphates of the nucleosides—was in a correspondingly primitive state. It may well be asked why the chemistry of these groups of compounds was not further advanced, particularly since we recognize today that they occupy a central place in the history of the living cell. True, their full significance was for a long time unrecognized and emerged only slowly as biochemical research got into its stride but I think a more important reason is to be found in the physical properties of compounds of the nucleotide group. As water-soluble polar compounds with no proper melting points they were extremely difficult to handle by the classic techniques of organic chemistry, and were accordingly very discouraging substances to early workers. It is surely no accident that the major advances in the field have coincided with the appearance of new experimental techniques such as paper and ion-exchange chromatography, paper electrophoresis, and countercurrent distribution, peculiarly appropriate to the compounds of this group.
In 'Synthesis in the Study of Nucleotides', Nobel Lecture, 11 December 1957. In Nobel Lectures: Chemistry 1942-1962 (1964), 524.
The essential molecule of reproduction, DNA, … is composed of only four nitrogen bases (adenine, thymine, guanine, and cytosine), the sugar deoxyribose, and a phosphate. DNA’s intermediary, RNA, differs only by the substitution of the sugar ribose for deoxyribose and the nitrogen base uracil for thymine. The proteins of living organisms are made with a mere 20 amino acids, all arranged in a “left-handed” configuration. Taking into account all 28 building blocks, or “letters” (20 amino acids, five bases, two sugars, and one phosphate), the message is clear: With such a limited alphabet, all life must have had a common chemical origin.
In 'Cosmochemistry The Earliest Evolution', The Science Teacher (Oct 1983), 50, No. 7, 35.
The results suggest a helical structure (which must be very closely packed) containing probably 2, 3 or 4 coaxial nucleic acid chains per helical unit and having the phosphate groups near the outside.
Official Report, submitted in Feb 1952. In Anne Sayre, Rosalind Franklin and DNA (2000), 126.
In science it often happens that scientists say, 'You know that's a really good argument; my position is mistaken,' and then they would actually change their minds and you never hear that old view from them again. They really do it. It doesn't happen as often as it should, because scientists are human and change is sometimes painful. But it happens every day. I cannot recall the last time something like that happened in politics or religion.
(1987) -- 
