[After the flash of the atomic bomb test explosion] Fermi got up and dropped small pieces of paper … a simple experiment to measure the energy liberated by the explosion … [W]hen the front of the shock wave arrived (some seconds after the flash) the pieces of paper were displaced a few centimeters in the direction of propagation of the shock wave. From the distance of the source and from the displacement of the air due to the shock wave, he could calculate the energy of the explosion. This Fermi had done in advance having prepared himself a table of numbers, so that he could tell immediately the energy liberated from this crude but simple measurement. … It is also typical that his answer closely approximated that of the elaborate official measurements. The latter, however, were available only after several days’ study of the records, whereas Fermi had his within seconds.

[Choosing to become a geophysicist was] entirely accidental and was due to the difficulty of getting a job during the depression. There happened to be one available in Cambridge at the time when I needed it.

[I predict] the electricity generated by water power is the only thing that is going to keep future generations from freezing. Now we use coal whenever we produce electric power by steam engine, but there will be a time when there’ll be no more coal to use. That time is not in the very distant future. … Oil is too insignificant in its available supply to come into much consideration.

[Theory is] an explanation that has been confirmed to such a degree, by observation and experiment, that knowledgeable experts accept it as fact. That’s what scientists mean when they talk about a theory: not a dreamy and unreliable speculation, but an explanatory statement that fits the evidence. They embrace such an explanation confidently but provisionally—taking it as their best available view of reality, at least until some severely conflicting data or some better explanation might come along.

If the Indians hadn’t spent the $24. In 1626 Peter Minuit, first governor of New Netherland, purchased Manhattan Island from the Indians for about $24. … Assume for simplicity a uniform rate of 7% from 1626 to the present, and suppose that the Indians had put their $24 at [compound] interest at that rate …. What would be the amount now, after 280 years? 24 x (1.07)280 = more than 4,042,000,000.
The latest tax assessment available at the time of writing gives the realty for the borough of Manhattan as $3,820,754,181. This is estimated to be 78% of the actual value, making the actual value a little more than $4,898,400,000.
The amount of the Indians’ money would therefore be more than the present assessed valuation but less than the actual valuation.

Parkinson's First Law: Work expands so as to fill the time available for its completion.

A fear of intellectual inadequacy, of powerlessness before the tireless electronic wizards, has given rise to dozens of science-fiction fantasies of computer takeovers. ... Other scientists too are apprehensive. D. Raj Reddy, a computer scientist at Pittsburgh’s Carnegie-Mellon University, fears that universally available microcomputers could turn into formidable weapons. Among other things, says Reddy, sophisticated computers in the wrong hands could begin subverting a society by tampering with people’s relationships with their own computers—instructing the other computers to cut off telephone, bank and other services, for example.

A good theoretical physicist today might find it useful to have a wide range of physical viewpoints and mathematical expressions of the same theory (for example, of quantum electrodynamics) available to him. This may be asking too much of one man. Then new students should as a class have this. If every individual student follows the same current fashion in expressing and thinking about electrodynamics or field theory, then the variety of hypotheses being generated to understand strong interactions, say, is limited. Perhaps rightly so, for possibly the chance is high that the truth lies in the fashionable direction. But, on the off-chance that it is in another direction—a direction obvious from an unfashionable view of field theory—who will find it?

Access to more information isn’t enough—the information needs to be correct, timely, and presented in a manner that enables the reader to learn from it. The current network is full of inaccurate, misleading, and biased information that often crowds out the valid information. People have not learned that “popular” or “available” information is not necessarily valid.

All in all, the total amount of power conceivably available from the uranium and thorium supplies of the earth is about twenty times that available from the coal and oil we have left.

Among people I have met, the few whom I would term “great” all share a kind of unquestioned, fierce dedication; an utter lack of doubt about the value of their activities (or at least an internal impulse that drives through any such angst); and above all, a capacity to work (or at least to be mentally alert for unexpected insights) at every available moment of every day of their lives.

An honest man, armed with all the knowledge available to us now, could only state that in some sense, the origin of life appears at the moment to be almost a miracle, so many are the conditions which would have had to have been satisfied to get it going. But this should not be taken to imply that there are good reasons to believe that it could not have started on the earth by a perfectly reasonable sequence of fairly ordinary chemical reactions. The plain fact is that the time available was too long, the many microenvironments on the earth’s surface too diverse, the various chemical possibilities too numerous and our own knowledge and imagination too feeble to allow us to be able to unravel exactly how it might or might not have happened such a long time ago, especially as we have no experimental evidence from that era to check our ideas against.

As a scientist, I am hostile to fundamentalist religion because it actively debauches the scientific enterprise. It teaches us not to change our minds, and not to want to know exciting things that are available to be known. It subverts science and saps the intellect.

Available energy is energy which we can direct into any desired channel. Dissipated energy is energy which we cannot lay hold of and direct at pleasure, such as the energy of the confused agitation of molecules which we call heat. Now, confusion, like the correlative term order, is not a property of material things in themselves, but only in relation to the mind which perceives them. A memorandum-book does not, provided it is neatly written, appear confused to an illiterate person, or to the owner who understands it thoroughly, but to any other person able to read it appears to be inextricably confused. Similarly the notion of dissipated energy could not occur to a being who could not turn any of the energies of nature to his own account, or to one who could trace the motion of every molecule and seize it at the right moment. It is only to a being in the intermediate stage, who can lay hold of some forms of energy while others elude his grasp, that energy appears to be passing inevitably from the available to the dissipated state.

Available energy is the main object at stake in the struggle for existence and the evolution of the world.

Be suspicious of a theory if more and more hypotheses are needed to support it as new facts become available, or as new considerations are brought to bear.

Benford's Law of Controversy: Passion is inversely proportional to the amount of real information available.

Bernard Bolzano dispelled the clouds that throughout all the foregone centuries had enveloped the notion of Infinitude in darkness, completely sheared the great term of its vagueness without shearing it of its strength, and thus rendered it forever available for the purposes of logical discourse.

Conclusion: Big helix in several chains, phosphates on outside, phosphate-phosphate inter-helical bonds disrupted by water. Phosphate links available to proteins.

Consider the plight of a scientist of my age. I graduated from the University of California at Berkeley in 1940. In the 41 years since then the amount of biological information has increased 16 fold; during these 4 decades my capacity to absorb new information has declined at an accelerating rate and now is at least 50% less than when I was a graduate student. If one defines ignorance as the ratio of what is available to be known to what is known, there seems no alternative to the conclusion that my ignorance is at least 25 times as extensive as it was when I got my bachelor’s degree. Although I am sure that my unfortunate condition comes as no surprise to my students and younger colleagues, I personally find it somewhat depressing. My depression is tempered, however, by the fact that all biologists, young or old, developing or senescing, face the same melancholy situation because of an interlocking set of circumstances.

Engineers participate in the activities which make the resources of nature available in a form beneficial to man and provide systems which will perform optimally and economically.

Food is at present obtained almost entirely from the energy of the sunlight. The radiation from the sun produces from the carbonic acid in the air more or less complicated carbon compounds which serve us in plants and vegetables. We use the latent chemical energy of these to keep our bodies warm, we convert it into muscular effort. We employ it in the complicated process of digestion to repair and replace the wasted cells of our bodies. … If the gigantic sources of power become available, food would be produced without recourse to sunlight. Vast cellars, in which artificial radiation is generated, may replace the cornfields and potato patches of the world.

I had made up my mind to find that for which I was searching even if it required the remainder of my life. After innumerable failures I finally uncovered the principle for which I was searching, and I was astounded at its simplicity. I was still more astounded to discover the principle I had revealed not only beneficial in the construction of a mechanical hearing aid but it served as well as means of sending the sound of the voice over a wire. Another discovery which came out of my investigation was the fact that when a man gives his order to produce a definite result and stands by that order it seems to have the effect of giving him what might be termed a second sight which enables him to see right through ordinary problems. What this power is I cannot say; all I know is that it exists and it becomes available only when a man is in that state of mind in which he knows exactly what he wants and is fully determined not to quit until he finds it.

I have been especially fortunate for about 50 years in having two memory banks available—whenever I can't remember something I ask my wife, and thus I am able to draw on this auxiliary memory bank. Moreover, there is a second way In which I get ideas ... I listen carefully to what my wife says, and in this way I often get a good idea. I recommend to ... young people ... that you make a permanent acquisition of an auxiliary memory bank that you can become familiar with and draw upon throughout your lives.

I have no doubt that certain learned men, now that the novelty of the hypotheses in this work has been widely reported—for it establishes that the Earth moves, and indeed that the Sun is motionless in the middle of the universe—are extremely shocked, and think that the scholarly disciplines, rightly established once and for all, should not be upset. But if they are willing to judge the matter thoroughly, they will find that the author of this work has committed nothing which deserves censure. For it is proper for an astronomer to establish a record of the motions of the heavens with diligent and skilful observations, and then to think out and construct laws for them, or rather hypotheses, whatever their nature may be, since the true laws cannot be reached by the use of reason; and from those assumptions the motions can be correctly calculated, both for the future and for the past. Our author has shown himself outstandingly skilful in both these respects. Nor is it necessary that these hypotheses should be true, nor indeed even probable, but it is sufficient if they merely produce calculations which agree with the observations. … For it is clear enough that this subject is completely and simply ignorant of the laws which produce apparently irregular motions. And if it does work out any laws—as certainly it does work out very many—it does not do so in any way with the aim of persuading anyone that they are valid, but only to provide a correct basis for calculation. Since different hypotheses are sometimes available to explain one and the same motion (for instance eccentricity or an epicycle for the motion of the Sun) an astronomer will prefer to seize on the one which is easiest to grasp; a philosopher will perhaps look more for probability; but neither will grasp or convey anything certain, unless it has been divinely revealed to him. Let us therefore allow these new hypotheses also to become known beside the older, which are no more probable, especially since they are remarkable and easy; and let them bring with them the vast treasury of highly learned observations. And let no one expect from astronomy, as far as hypotheses are concerned, anything certain, since it cannot produce any such thing, in case if he seizes on things constructed for another other purpose as true, he departs from this discipline more foolish than he came to it.

I knew, however, that it would cost ten times what I had available in order to build a molecular beam machine. I decided to follow a byway, rather than the highway. It is a procedure I have subsequently recommended to beginning scientists in this country, where research strategy is best modelled on that used by Wolfe at the Plains of Abraham.
(British General James Wolfe defeated the French defending Quebec in 1759 after scaling a cliff for a surprise attack.)

If I choose to impose individual blame for all past social ills, there will be no one left to like in some of the most fascinating periods of our history. For example ... if I place every Victorian anti-Semite beyond the pale of my attention, my compass of available music and literature will be pitifully small. Though I hold no shred of sympathy for active persecution, I cannot excoriate individuals who acquiesced passively in a standard societal judgment. Rail instead against the judgment, and try to understand what motivates men of decent will.

If I would be a young man again and had to decide how to make my living, I would not try to become a scientist or scholar or teacher. I would rather choose to be a plumber or a peddler in the hope to find that modest degree of independence still available under present circumstances.

Imagine a room awash in gasoline, and there are two implacable enemies in that room. One of them has nine thousand matches. The other has seven thousand matches. Each of them is concerned about who's ahead, who's stronger. Well that's the kind of situation we are actually in. The amount of weapons that are available to the United States and the Soviet Union are so bloated, so grossly in excess of what's needed to dissuade the other, that if it weren't so tragic, it would be laughable. What is necessary is to reduce the matches and to clean up the gasoline.

Imagine the chaos that would arise if time machines were as common as automobiles, with tens of millions of them commercially available. Havoc would soon break loose, tearing at the fabric of our universe. Millions of people would go back in time to meddle with their own past and the past of others, rewriting history in the process. … It would thus be impossible to take a simple census to see how many people there were at any given time.

In early times, when the knowledge of nature was small, little attempt was made to divide science into parts, and men of science did not specialize. Aristotle was a master of all science known in his day, and wrote indifferently treatises on physics or animals. As increasing knowledge made it impossible for any one man to grasp all scientific subjects, lines of division were drawn for convenience of study and of teaching. Besides the broad distinction into physical and biological science, minute subdivisions arose, and, at a certain stage of development, much attention was, given to methods of classification, and much emphasis laid on the results, which were thought to have a significance beyond that of the mere convenience of mankind.
But we have reached the stage when the different streams of knowledge, followed by the different sciences, are coalescing, and the artificial barriers raised by calling those sciences by different names are breaking down. Geology uses the methods and data of physics, chemistry and biology; no one can say whether the science of radioactivity is to be classed as chemistry or physics, or whether sociology is properly grouped with biology or economics. Indeed, it is often just where this coalescence of two subjects occurs, when some connecting channel between them is opened suddenly, that the most striking advances in knowledge take place. The accumulated experience of one department of science, and the special methods which have been developed to deal with its problems, become suddenly available in the domain of another department, and many questions insoluble before may find answers in the new light cast upon them. Such considerations show us that science is in reality one, though we may agree to look on it now from one side and now from another as we approach it from the standpoint of physics, physiology or psychology.

In the application of inductive logic to a given knowledge situation, the total evidence available must be used as a basis for determining the degree of confirmation.

In the discussion of the. energies involved in the deformation of nuclei, the concept of surface tension of nuclear matter has been used and its value had been estimated from simple considerations regarding nuclear forces. It must be remembered, however, that the surface tension of a charged droplet is diminished by its charge, and a rough estimate shows that the surface tension of nuclei, decreasing with increasing nuclear charge, may become zero for atomic numbers of the order of 100. It seems therefore possible that the uranium nucleus has only small stability of form, and may, after neutron capture, divide itself into two nuclei of roughly equal size (the precise ratio of sizes depending on liner structural features and perhaps partly on chance). These two nuclei will repel each other and should gain a total kinetic energy of c. 200 Mev., as calculated from nuclear radius and charge. This amount of energy may actually be expected to be available from the difference in packing fraction between uranium and the elements in the middle of the periodic system. The whole 'fission' process can thus be described in an essentially classical way, without having to consider quantum-mechanical 'tunnel effects', which would actually be extremely small, on account of the large masses involved.
[Co-author with Otto Robert Frisch]

In the sense that [truth] means the reality about a human being it is probably impossible for a biographer to achieve. In the sense that it means a reasonable presentation of all the available facts it is more nearly possible, but even this limited goal is harder to reach than it appears to be. A biographer needs to be both humble and cautious.

It is evident that certain genes which either initially or ultimately have beneficial effects may at the same time produce characters of a non-adaptive type, which will therefore be established with them. Such characters may sometimes serve most easily to distinguish different races or species; indeed, they may be the only ones ordinarily available, when the advantages with which they are associated are of a physiological nature. Further, it may happen that the chain of reactions which a gene sets going is of advantage, while the end-product to which this gives rise, say a character in a juvenile or the adult stage, is of no adaptive significance.

It is for such inquiries the modern naturalist collects his materials; it is for this that he still wants to add to the apparently boundless treasures of our national museums, and will never rest satisfied as long as the native country, the geographical distribution, and the amount of variation of any living thing remains imperfectly known. He looks upon every species of animal and plant now living as the individual letters which go to make up one of the volumes of our earth’s history; and, as a few lost letters may make a sentence unintelligible, so the extinction of the numerous forms of life which the progress of cultivation invariably entails will necessarily render obscure this invaluable record of the past. It is, therefore, an important object, which governments and scientific institutions should immediately take steps to secure, that in all tropical countries colonised by Europeans the most perfect collections possible in every branch of natural history should be made and deposited in national museums, where they may be available for study and interpretation. If this is not done, future ages will certainly look back upon us as a people so immersed in the pursuit of wealth as to be blind to higher considerations. They will charge us with having culpably allowed the destruction of some of those records of Creation which we had it in our power to preserve; and while professing to regard every living thing as the direct handiwork and best evidence of a Creator, yet, with a strange inconsistency, seeing many of them perish irrecoverably from the face of the earth, uncared for and unknown.

It is my thesis that the physical functioning of the living individual and the operation of some of the newer communication machines are precisely parallel in their analogous attempts to control entropy through feedback. Both of them have sensory receptors as one stage in their cycle of operation: that is, in both of them there exists a special apparatus for collecting information from the outer world at low energy levels, and for making it available in the operation of the individual or of the machine. In both cases these external messages are not taken neat, but through the internal transforming powers of the apparatus, whether it be alive or dead. The information is then turned into a new form available for the further stages of performance. In both the animal and the machine this performance is made to be effective on the outer world. In both of them, their performed action on the outer world, and not merely their intended aetion, is reported back to the central regulatory apparatus.

It might be argued that a genetically enhanced athlete, like a drug-enhanced one, would have an unfair advantage over his unenhanced competitors. But the fairness argument against enhancement has a fatal flaw: it has always been the case that some athletes are better endowed genetically than others, and yet we do not consider this to undermine the fairness of competitive sports. From the standpoint of fairness, enhanced genetic differences would be no worse than natural ones, assuming they were safe and made available to all. If genetic enhancement in sports is morally objectionable, it must be for reasons other than fairness.

Malthus argued a century and a half ago that man, by using up all his available resources, would forever press on the limits of subsistence, thus condemning humanity to an indefinite future of misery and poverty. We can now begin to hope and, I believe, know that Malthus was expressing not a law of nature, but merely the limitation then of scientific and social wisdom. The truth or falsity of his prediction will depend now, with the tools we have, on our own actions, now and in the years to come.

Mathematics gives the young man a clear idea of demonstration and habituates him to form long trains of thought and reasoning methodically connected and sustained by the final certainty of the result; and it has the further advantage, from a purely moral point of view, of inspiring an absolute and fanatical respect for truth. In addition to all this, mathematics, and chiefly algebra and infinitesimal calculus, excite to a high degree the conception of the signs and symbols—necessary instruments to extend the power and reach of the human mind by summarizing an aggregate of relations in a condensed form and in a kind of mechanical way. These auxiliaries are of special value in mathematics because they are there adequate to their definitions, a characteristic which they do not possess to the same degree in the physical and mathematical [natural?] sciences.
There are, in fact, a mass of mental and moral faculties that can be put in full play only by instruction in mathematics; and they would be made still more available if the teaching was directed so as to leave free play to the personal work of the student.

My interest in the biology of tissue and organ transplantation arose from my [WW II] military experience at Valley Forge General Hospital in Pennsylvania … a major plastic surgical center. While there, I spent all my available spare time on the plastic surgical wards which were jammed with hundreds of battle casualties. I enjoyed talking to the patients, helping with dressings, and observing the results of the imaginative reconstructive surgical operations.

My sense is that the most under-appreciated–and perhaps most under-researched–linkages between forests and food security are the roles that forest-based ecosystem services play in underpinning sustainable agricultural production. Forests regulate hydrological services including the quantity, quality, and timing of water available for irrigation. Forest-based bats and bees pollinate crops. Forests mitigate impacts of climate change and extreme weather events at the landscape scale.

Now, it may be stretching an analogy to compare epidemics of cholera—caused by a known agent—with that epidemic of violent crime which is destroying our cities. It is unlikely that our social problems can be traced to a single, clearly defined cause in the sense that a bacterial disease is ‘caused’ by a microbe. But, I daresay, social science is about as advanced in the late twentieth century as bacteriological science was in the mid nineteenth century. Our forerunners knew something about cholera; they sensed that its spread was associated with misdirected sewage, filth, and the influx of alien poor into crowded, urban tenements. And we know something about street crime; nowhere has it been reported that a member of the New York Stock Exchange has robbed ... at the point of a gun. Indeed, I am naively confident that an enlightened social scientist of the next century will be able to point out that we had available to us at least some of the clues to the cause of urban crime.

One of the major goals when studying specific genetic diseases is to find the primary gene product, which in turn leads to a better understanding of the biochemical basis of the disorder. The bottom line often reads, 'This may lead to effective prenatal diagnosis and eventual eradication of the disease.' But we now have the ironic situation of being able to jump right to the bottom line without reading the rest of the page, that is, without needing to identify the primary gene product or the basic biochemical mechanism of the disease. The technical capability of doing this is now available. Since the degree of departure from our previous approaches and the potential of this procedure are so great, one will not be guilty of hyperbole in calling it the 'New Genetics'.

One reason which has led the organic chemist to avert his mind from the problems of Biochemistry is the obsession that the really significant happenings in the animal body are concerned in the main with substances of such high molecular weight and consequent vagueness of molecular structure as to make their reactions impossible of study by his available and accurate methods. There remains, I find, pretty widely spread, the feeling—due to earlier biological teaching—that, apart from substances which are obviously excreta, all the simpler products which can be found in cells or tissues are as a class mere objects, already too remote from the fundamental biochemical events to have much significance. So far from this being the case, recent progress points in the clearest way to the fact that the molecules with which a most important and significant part of the chemical dynamics of living tissues is concerned are of a comparatively simple character.

Our world is not an optimal place, fine tuned by omnipotent forces of selection. It is a quirky mass of imperfections, working well enough (often admirably); a jury-rigged set of adaptations built of curious parts made available by past histories in different contexts ... A world optimally adapted to current environments is a world without history, and a world without history might have been created as we find it. History matters; it confounds perfection and proves that current life transformed its own past.

Over the past fifty years or so, scientists have allowed the conventions of expression available to them to become entirely too confining. too confining. The insistence on bland impersonality and the widespread indifference to anything like the display of a unique human author in scientific exposition, have transformed the reading of most scientific papers into an act of tedious drudgery.

Owing to his lack of knowledge, the ordinary man cannot attempt to resolve conflicting theories of conflicting advice into a single organized structure. He is likely to assume the information available to him is on the order of what we might think of as a few pieces of an enormous jigsaw puzzle. If a given piece fails to fit, it is not because it is fraudulent; more likely the contradictions and inconsistencies within his information are due to his lack of understanding and to the fact that he possesses only a few pieces of the puzzle. Differing statements about the nature of things, differing medical philosophies, different diagnoses and treatments—all of these are to be collected eagerly and be made a part of the individual's collection of puzzle pieces. Ultimately, after many lifetimes, the pieces will fit together and the individual will attain clear and certain knowledge.

Personally I think there is no doubt that sub-atomic energy is available all around us, and that one day man will release and control its almost infinite power. We cannot prevent him from doing so and can only hope that he will not use it exclusively in blowing up his next door neighbour. (1936)

Positivism is a theory of knowledge according to which the only kind of sound knowledge available to human kind is that if science grounded in observation.

Quite distinct from the theoretical question of the manner in which mathematics will rescue itself from the perils to which it is exposed by its own prolific nature is the practical problem of finding means of rendering available for the student the results which have been already accumulated, and making it possible for the learner to obtain some idea of the present state of the various departments of mathematics. … The great mass of mathematical literature will be always contained in Journals and Transactions, but there is no reason why it should not be rendered far more useful and accessible than at present by means of treatises or higher text-books. The whole science suffers from want of avenues of approach, and many beautiful branches of mathematics are regarded as difficult and technical merely because they are not easily accessible. … I feel very strongly that any introduction to a new subject written by a competent person confers a real benefit on the whole science. The number of excellent text-books of an elementary kind that are published in this country makes it all the more to be regretted that we have so few that are intended for the advanced student. As an example of the higher kind of text-book, the want of which is so badly felt in many subjects, I may mention the second part of Prof. Chrystal’s Algebra published last year, which in a small compass gives a great mass of valuable and fundamental knowledge that has hitherto been beyond the reach of an ordinary student, though in reality lying so close at hand. I may add that in any treatise or higher text-book it is always desirable that references to the original memoirs should be given, and, if possible, short historic notices also. I am sure that no subject loses more than mathematics by any attempt to dissociate it from its history.

Religion shows a pattern of heredity which I think is similar to genetic heredity. ... There are hundreds of different religious sects, and every religious person is loyal to just one of these. ... The overwhelming majority just happen to choose the one their parents belonged to. Not the sect that has the best evidence in its favour, the best miracles, the best moral code, the best cathedral, the best stained-glass, the best music when it comes to choosing from the smorgasbord of available religions, their potential virtues seem to count for nothing compared to the matter of heredity.

Science is best defined as a careful, disciplined, logical search for knowledge about any and all aspects of the universe, obtained by examination of the best available evidence and always subject to correction and improvement upon discovery of better evidence. What's left is magic. And it doesn't work.

Science, history and politics are not suited for discussion except by experts. Others are simply in the position of requiring more information; and, till they have acquired all available information, cannot do anything but accept on authority the opinions of those better qualified.

The American Cancer Society's position on the question of a possible cause-effect relationship between cigarette smoking and lung cancer is:
1. The evidence to date justifies suspicion that cigarette smoking does, to a degree as yet undetermined, increase the likelihood of developing cancer of the lung.
2. That available evidence does not constitute irrefutable proof that cigarette smoking is wholly or chiefly or partly responsible for lung cancer.
3. That the evidence at hand calls for the extension of statistical and laboratory studies designed to confirm or deny a causual relationship between cigarette smoking and lung cancer.
4. That the society is committed to furthering such intensified investigation as its resources will permit.

The amount of knowledge which we can justify from evidence directly available to us can never be large. The overwhelming proportion of our factual beliefs continue therefore to be held at second hand through trusting others, and in the great majority of cases our trust is placed in the authority of comparatively few people of widely acknowledged standing.

The Analytical Engine has no pretensions whatever to originate anything. It can do whatever we know how to order it to perform. It can follow analysis; but it has no power of anticipating any analytical relations or truths. Its province is to assist us to making available what we are already acquainted with.
[Describing Charles Babbage's machine.]

The energy available for each individual man is his income, and the philosophy which can teach him to be content with penury should be capable of teaching him also the uses of wealth.

The enthusiasm of Sylvester for his own work, which manifests itself here as always, indicates one of his characteristic qualities: a high degree of subjectivity in his productions and publications. Sylvester was so fully possessed by the matter which for the time being engaged his attention, that it appeared to him and was designated by him as the summit of all that is important, remarkable and full of future promise. It would excite his phantasy and power of imagination in even a greater measure than his power of reflection, so much so that he could never marshal the ability to master his subject-matter, much less to present it in an orderly manner.
Considering that he was also somewhat of a poet, it will be easier to overlook the poetic flights which pervade his writing, often bombastic, sometimes furnishing apt illustrations; more damaging is the complete lack of form and orderliness of his publications and their sketchlike character, … which must be accredited at least as much to lack of objectivity as to a superfluity of ideas. Again, the text is permeated with associated emotional expressions, bizarre utterances and paradoxes and is everywhere accompanied by notes, which constitute an essential part of Sylvester’s method of presentation, embodying relations, whether proximate or remote, which momentarily suggested themselves. These notes, full of inspiration and occasional flashes of genius, are the more stimulating owing to their incompleteness. But none of his works manifest a desire to penetrate the subject from all sides and to allow it to mature; each mere surmise, conceptions which arose during publication, immature thoughts and even errors were ushered into publicity at the moment of their inception, with utmost carelessness, and always with complete unfamiliarity of the literature of the subject. Nowhere is there the least trace of self-criticism. No one can be expected to read the treatises entire, for in the form in which they are available they fail to give a clear view of the matter under contemplation.
Sylvester’s was not a harmoniously gifted or well-balanced mind, but rather an instinctively active and creative mind, free from egotism. His reasoning moved in generalizations, was frequently influenced by analysis and at times was guided even by mystical numerical relations. His reasoning consists less frequently of pure intelligible conclusions than of inductions, or rather conjectures incited by individual observations and verifications. In this he was guided by an algebraic sense, developed through long occupation with processes of forms, and this led him luckily to general fundamental truths which in some instances remain veiled. His lack of system is here offset by the advantage of freedom from purely mechanical logical activity.
The exponents of his essential characteristics are an intuitive talent and a faculty of invention to which we owe a series of ideas of lasting value and bearing the germs of fruitful methods. To no one more fittingly than to Sylvester can be applied one of the mottos of the Philosophic Magazine:
“Admiratio generat quaestionem, quaestio investigationem investigatio inventionem.”

The evidence at present available points strongly to the conclusion that the spirals are individual galaxies, or island universes, comparable with our own galaxy in dimension and in number of component units.
[Stating his conviction on the nature of nebulae during the Shapley-Curtis debate on 26 Apr 1920 to the National Academy of Sciences.]

The frequent allegation that the selective processes in the human species are no longer 'natural' is due to persistence of the obsolete nineteenth-century concept of 'natural' selection. The error of this view is made clear when we ask its proponents such questions as, why should the 'surviving fittest' be able to withstand cold and inclement weather without the benefit of fire and clothing? Is it not ludicrous to expect selection to make us good at defending ourselves against wild beasts when wild beasts are getting to be so rare that it is a privilege to see one outside of a zoo? Is it necessary to eliminate everyone who has poor teeth when our dentists stand ready to provide us with artificial ones? Is it a great virtue to be able to endure pain when anaesthetics are available?
[Co-author with American statistician Gordon Allen]

The history of man is dominated by, and reflects, the amount of available energy.

The maintenance of biological diversity requires special measures that extend far beyond the establishment of nature reserves. Several reasons for this stand out. Existing reserves have been selected according to a number of criteria, including the desire to protect nature, scenery, and watersheds, and to promote cultural values and recreational opportunities. The actual requirements of individual species, populations, and communities have seldom been known, nor has the available information always been employed in site selection and planning for nature reserves. The use of lands surrounding nature reserves has typically been inimical to conservation, since it has usually involved heavy use of pesticides, industrial development, and the presence of human settlements in which fire, hunting, and firewood gathering feature as elements of the local economy.

The question of a possible physiological significance, in the resemblance between the action of choline esters and the effects of certain divisions of the involuntary nervous system, is one of great interest, but one for the discussion of which little evidence is available. Acetyl-choline is, of all the substances examined, the one whose action is most suggestive in this direction. The fact that its action surpasses even that of adrenaline, both in intensity and evanescence, when considered in conjunction with the fact that each of these two bases reproduces those effects of involuntary nerves which are absent from the action of the other, so that the two actions are in many directions at once complementary and antagonistic, gives plenty of scope for speculation.

The sea itself offers a perennial source of power hitherto almost unapplied. The tides, twice in each day, raise a vast mass of water, which might be made available for driving machinery.

The theory here developed is that mega-evolution normally occurs among small populations that become preadaptive and evolve continuously (without saltation, but at exceptionally rapid rates) to radically different ecological positions. The typical pattern involved is probably this: A large population is fragmented into numerous small isolated lines of descent. Within these, inadaptive differentiation and random fixation of mutations occur. Among many such inadaptive lines one or a few are preadaptive, i.e., some of their characters tend to fit them for available ecological stations quite different from those occupied by their immediate ancestors. Such groups are subjected to strong selection pressure and evolve rapidly in the further direction of adaptation to the new status. The very few lines that successfully achieve this perfected adaptation then become abundant and expand widely, at the same time becoming differentiated and specialized on lower levels within the broad new ecological zone.

The theory of probability is the only mathematical tool available to help map the unknown and the uncontrollable. It is fortunate that this tool, while tricky, is extraordinarily powerful and convenient.

There are no better terms available to describe the difference between the approach of the natural and the social sciences than to call the former ‘objective’ and the latter ‘subjective.’ ... While for the natural scientist the contrast between objective facts and subjective opinions is a simple one, the distinction cannot as readily be applied to the object of the social sciences. The reason for this is that the object, the ‘facts’ of the social sciences are also opinions—not opinions of the student of the social phenomena, of course, but opinions of those whose actions produce the object of the social scientist.

Therefore on long pondering this uncertainty of mathematical traditions on the deduction of the motions of the system of the spheres, I began to feel disgusted that no more certain theory of the motions of the mechanisms of the universe, which has been established for us by the best and most systematic craftsman of all, was agreed by the philosophers, who otherwise theorised so minutely with most careful attention to the details of this system. I therefore set myself the task of reading again the books of all philosophers which were available to me, to search out whether anyone had ever believed that the motions of the spheres of the, universe were other than was supposed by those who professed mathematics in the schools.

These are some of the things wilderness can do for us. That is the reason we need to put into effect, for its preservation, some other principle that the principles of exploitation or “usefulness” or even recreation. We simply need that wild country available to us, even if we never do more than drive to its edge and look in. For it can be a means of reassuring ourselves of our sanity as creatures, a part of the geography of hope.

This is the goal: To make available for life every place where life is possible. To make inhabitable all worlds as yet uninhabitable, and all life purposeful.

Through [the growing organism's] power of assimilation there is a constant encroachment of the organic upon the inorganic, a constant attempt to convert all available material into living substance, and to indefinitely multiply the total number of individual organisms.

Thus, we have three principles for increasing adequacy of data: if you must work with a single object, look for imperfections that record historical descent; if several objects are available, try to render them as stages of a single historical process; if processes can be directly observed, sum up their effects through time. One may discuss these principles directly or recognize the ‘little problems’ that Darwin used to exemplify them: orchids, coral reefs, and worms–the middle book, the first, and the last.

We have vastly increased the amount of funding that is available for conservation partnerships.

We simply need that wild country available to us, even if we never do more than drive to its edge and look in. For it can be a means of reassuring ourselves of our sanity as creatures, a part of the geography of hope.

What matters in science is the body of findings and generalizations available today: a time-defined cross-section of the process of scientific discovery. I see the advance of science as self-erasing in the sense that only those elements survive that have become part of the active body of knowledge.

When the great truth accidentally revealed and experimentally confirmed is fully recognized, that this planet, with all its appalling immensity, is to electric currents virtually no more than a small metal ball and that by this fact many possibilities, each baffling imagination and of incalculable consequence, are rendered absolutely sure of accomplishment; when the first plant is inaugurated and it is shown that a telegraphic message, almost as secret and non-interferable as a thought, can be transmitted to any terrestrial distance, the sound of the human voice, with all its intonations and inflections, faithfully and instantly reproduced at any other point of the globe, the energy of a waterfall made available for supplying light, heat or motive power, anywhere—on sea, or land, or high in the air—humanity will be like an ant heap stirred up with a stick: See the excitement coming!

When we burn fossil fuel for energy we are, in qualitative terms, doing nothing more wrong than burning wood. Our wrongdoing, if that is an appropriate term, is taking energy from Gaia hundreds of times faster than it is naturally made available. We are sinning in a quantitative not a qualitative way.

Why did I decide to undertake my doctorate research in the exotic field of boron hydrides? As it happened, my girl friend, Sarah Baylen, soon to become my wife, presented me with a graduation gift, Alfred Stock's book, The Hydrides of Boron and Silicon. I read this book and became interested in the subject. How did it happen that she selected this particular book? This was the time of the Depression. None of us had much money. It appears she selected as her gift the most economical chemistry book ($2.06) available in the University of Chicago bookstore. Such are the developments that can shape a career.

You must remember that nothing happens quite by chance. It’s a question of accretion of information and experience … it’s just chance that I happened to be here at this particular time when there was available and at my disposal the great experience of all the investigators who plodded along for a number of years.