...those experiments be not only esteemed which have an immediate and present use, but those principally which are of most universal consequence for invention of other experiments, and those which give more light to the invention of causes; for the invention of the mariner's needle, which giveth the direction, is of no less benefit for navigation than the invention of the sails, which give the motion.

Dass die bis jetzt unzerlegten chemischen Elemente absolut unzerlegbare Stoffe seien, ist gegenwärtig mindestens sehr unwahrscheinlich. Vielmehr scheint es, dass die Atome der Elemente nicht die letzten, sondern nur die näheren Bestandtheile der Molekeln sowohl der Elemente wie der Verbindungen bilden, die Molekeln oder Molecule als Massentheile erster, die Atome als solche zweiter Ordnung anzusehen sind, die ihrerseits wiederum aus Massentheilchen einer dritten höheren Ordnung bestehen werden.
That the as yet undivided chemical elements are absolutely irreducible substances, is currently at least very unlikely. Rather it seems, that the atoms of elements are not the final, but only the immediate constituents of the molecules of both the elements and the compounds—the Molekeln or molecule as foremost division of matter, the atoms being considered as second order, in turn consisting of matter particles of a third higher order.
[Speculating in 1870, on the existence of subatomic particles, in opening remark of the paper by which he became established as co-discoverer of the Periodic Law.]

1. Universal CHEMISTRY is the Art of resolving mixt, compound, or aggregate Bodies into their Principles; and of composing such Bodies from those Principles. 2. It has for its Subject all the mix’d, compound, and aggregate Bodies that are and resolvable and combinable and Resolution and Combination, or Destruction and Generation, for its Object. 3. Its Means in general, are either remote or immediate; that is, either Instruments or the Operations themselves. 4. Its End is either philosophical and theoretical; or medicinal, mechanical, œconomical, and practical. 5. Its efficient Cause is the Chemist.

A discovery in science, or a new theory, even when it appears most unitary and most all-embracing, deals with some immediate element of novelty or paradox within the framework of far vaster, unanalysed, unarticulated reserves of knowledge, experience, faith, and presupposition. Our progress is narrow; it takes a vast world unchallenged and for granted. This is one reason why, however great the novelty or scope of new discovery, we neither can, nor need, rebuild the house of the mind very rapidly. This is one reason why science, for all its revolutions, is conservative. This is why we will have to accept the fact that no one of us really will ever know very much. This is why we shall have to find comfort in the fact that, taken together, we know more and more.

A poem in my opinion, is opposed to a work of science by having for its immediate object, pleasure, not truth.

A terrible wilderness of mountainous country constitutes the immediate environment of St. Paul’s. It is a precipitous cliff into the abyss, a gate of hell, more horrible than the fantasy of Dante could express it.

Abstract thought is the neoteny of the intellect, by which man is able to continue to carry out activities which have no immediate goal.

According to Democritus, atoms had lost the qualities like colour, taste, etc., they only occupied space, but geometrical assertions about atoms were admissible and required no further analysis. In modern physics, atoms lose this last property, they possess geometrical qualities in no higher degree than colour, taste, etc. The atom of modern physics can only be symbolized by a partial differential equation in an abstract multidimensional space. Only the experiment of an observer forces the atom to indicate a position, a colour and a quantity of heat. All the qualities of the atom of modern physics are derived, it has no immediate and direct physical properties at all, i.e. every type of visual conception we might wish to design is, eo ipso, faulty. An understanding of 'the first order' is, I would almost say by definition, impossible for the world of atoms.

All men and women are born, live suffer and die; what distinguishes us one from another is our dreams, whether they be dreams about worldly or unworldly things, and what we do to make them come about... We do not choose to be born. We do not choose our parents. We do not choose our historical epoch, the country of our birth, or the immediate circumstances of our upbringing. We do not, most of us, choose to die; nor do we choose the time and conditions of our death. But within this realm of choicelessness, we do choose how we live.

All talk about science purely for its practical and wealth-producing results is … idle. … Practical results will follow right enough. No real knowledge is sterile. … With this faith in the ultimate usefulness of all real knowledge a man may proceed to devote himself to a study of first causes without apology, and without hope of immediate return.

And for rejecting such a Medium, we have the Authority of those the oldest and most celebrated Philosophers of Greece and Phoenicia, who made a Vacuum, and Atoms, and the Gravity of Atoms, the first Principles of their Philosophy; tacitly attributing Gravity to some other Cause than dense Matter. Later Philosophers banish the Consideration of such a Cause out of natural Philosophy, feigning Hypotheses for explaining all things mechanically, and referring other Causes to Metaphysicks: Whereas the main Business of natural Philosophy is to argue from Phaenomena without feigning Hypotheses, and to deduce Causes from Effects, till we come to the very first Cause, which certainly is not mechanical; and not only to unfold the Mechanism of the World, but chiefly to resolve these and such like Questions. What is there in places almost empty of Matter, and whence is it that the Sun and Planets gravitate towards one another, without dense Matter between them? Whence is it that Nature doth nothing in vain; and whence arises all that Order and Beauty which we see in the World? ... does it not appear from phaenomena that there is a Being incorporeal, living, intelligent, omnipresent, who in infinite space, as it were in his Sensory, sees the things themselves intimately, and thoroughly perceives them, and comprehends them wholly by their immediate presence to himself.

Archimedes constructing his circle pays with his life for his defective biological adaptation to immediate circumstances.

Asian Homo erectus died without issue and does not enter our immediate ancestry (for we evolved from African populations); Neanderthal people were collateral cousins, perhaps already living in Europe while we emerged in Africa... In other words, we are an improbable and fragile entity, fortunately successful after precarious beginnings as a small population in Africa, not the predictable end result of a global tendency. We are a thing, an item of history, not an embodiment of general principles.

But of all environments, that produced by man’s complex technology is perhaps the most unstable and rickety. In its present form, our society is not two centuries old, and a few nuclear bombs will do it in.
To be sure, evolution works over long periods of time and two centuries is far from sufficient to breed Homo technikos… .
The destruction of our technological society in a fit of nuclear peevishness would become disastrous even if there were many millions of immediate survivors.
The environment toward which they were fitted would be gone, and Darwin’s demon would wipe them out remorselessly and without a backward glance.

Civilization is in no immediate danger of running out of energy or even just out of oil. But we are running out of environment—that is, out of the capacity of the environment to absorb energy's impacts without risk of intolerable disruption—and our heavy dependence on oil in particular entails not only environmental but also economic and political liabilities.

Every well established truth is an addition to the sum of human power, and though it may not find an immediate application to the economy of every day life, we may safely commit it to the stream of time, in the confident anticipation that the world will not fail to realize its beneficial results.

Examine your words well, and you will find that even when you have no motive to be false, it is a very hard thing to say the exact truth, even about your own immediate feelings—much harder than to say something fine about them which is not the exact truth.

From our home on the Earth, we look out into the distances and strive to imagine the sort of world into which we were born. Today, we have reached far into space. Our immediate neighborhood we know rather intimately. But with increasing distance our knowledge fades … The search will continue. The urge is older than history. It is not satisfied and will not be suppressed.

I am truly a ‘lone traveler’ and have never belonged to my country, my home, my friends, or even my immediate family, with my whole heart; in the face of all these ties, I have never lost a sense of distance and a need for solitude.

I confess, that very different from you, I do find sometimes scientific inspiration in mysticism … but this is counterbalanced by an immediate sense for mathematics.

I do not share in this reverence for knowledge as such. It all depends on who has the knowledge and what he does with it. That knowledge which adds greatly to character is knowledge so handled as to transform every phase of immediate experience.

I gang my own gait and have never belonged to my country, my home, my friends, or even my immediate family, with my whole heart; in the face of all these ties I have never lost an obstinate sense of detachment, of the need for solitude–a feeling which increases with the years.

I recall my own emotions: I had just been initiated into the mysteries of the complex number. I remember my bewilderment: here were magnitudes patently impossible and yet susceptible of manipulations which lead to concrete results. It was a feeling of dissatisfaction, of restlessness, a desire to fill these illusory creatures, these empty symbols, with substance. Then I was taught to interpret these beings in a concrete geometrical way. There came then an immediate feeling of relief, as though I had solved an enigma, as though a ghost which had been causing me apprehension turned out to be no ghost at all, but a familiar part of my environment.

I then began to study arithmetical questions without any great apparent result, and without suspecting that they could have the least connexion with my previous researches. Disgusted at my want of success, I went away to spend a few days at the seaside, and thought of entirely different things. One day, as I was walking on the cliff, the idea came to me, again with the same characteristics of conciseness, suddenness, and immediate certainty, that arithmetical transformations of indefinite ternary quadratic forms are identical with those of non-Euclidian geometry.

I think I may fairly make two postulata. First, That food is necessary to the existence of man. Secondly, That the passion between the sexes is necessary and will remain nearly in its present state. These two laws ever since we have had any knowledge of mankind, appear to have been fixed laws of our nature; and, as we have not hitherto seen any alteration in them, we have no right to conclude that they will ever cease to be what they are now, without an immediate act of power in that Being who first arranged the system of the universe; and for the advantage of his creatures, still executes, according to fixed laws, all its various operations.

If the task of scientific methodology is to piece together an account of what scientists actually do, then the testimony of biologists should be heard with specially close attention. Biologists work very close to the frontier between bewilderment and understanding.
Biology is complex, messy and richly various, like real life; it travels faster nowadays than physics or chemistry (which is just as well, since it has so much farther to go), and it travels nearer to the ground. It should therefore give us a specially direct and immediate insight into science in the making.

In an age of egoism, it is so difficult to persuade man that of all studies, the most important is that of himself. This is because egoism, like all passions, is blind. The attention of the egoist is directed to the immediate needs of which his senses give notice, and cannot be raised to those reflective needs that reason discloses to us; his aim is satisfaction, not perfection. He considers only his individual self; his species is nothing to him. Perhaps he fears that in penetrating the mysteries of his being he will ensure his own abasement, blush at his discoveries, and meet his conscience. True philosophy, always at one with moral science, tells a different tale. The source of useful illumination, we are told, is that of lasting content, is in ourselves. Our insight depends above all on the state of our faculties; but how can we bring our faculties to perfection if we do not know their nature and their laws! The elements of happiness are the moral sentiments; but how can we develop these sentiments without considering the principle of our affections, and the means of directing them? We become better by studying ourselves; the man who thoroughly knows himself is the wise man. Such reflection on the nature of his being brings a man to a better awareness of all the bonds that unite us to our fellows, to the re-discovery at the inner root of his existence of that identity of common life actuating us all, to feeling the full force of that fine maxim of the ancients: 'I am a man, and nothing human is alien to me.'

In geometry, as in most sciences, it is very rare that an isolated proposition is of immediate utility. But the theories most powerful in practice are formed of propositions which curiosity alone brought to light, and which long remained useless without its being able to divine in what way they should one day cease to be so. In this sense it may be said, that in real science, no theory, no research, is in effect useless.

In scientific study, or, as I prefer to phrase it, in creative scholarship, the truth is the single end sought; all yields to that. The truth is supreme, not only in the vague mystical sense in which that expression has come to be a platitude, but in a special, definite, concrete sense. Facts and the immediate and necessary inductions from facts displace all pre-conceptions, all deductions from general principles, all favourite theories. Previous mental constructions are bowled over as childish play-structures by facts as they come rolling into the mind. The dearest doctrines, the most fascinating hypotheses, the most cherished creations of the reason and of the imagination perish from a mind thoroughly inspired with the scientific spirit in the presence of incompatible facts. Previous intellectual affections are crushed without hesitation and without remorse. Facts are placed before reasonings and before ideals, even though the reasonings and the ideals be more beautiful, be seemingly more lofty, be seemingly better, be seemingly truer. The seemingly absurd and the seemingly impossible are sometimes true. The scientific disposition is to accept facts upon evidence, however absurd they may appear to our pre-conceptions.

In the field of thinking, the whole history of science from geocentrism to the Copernican revolution, from the false absolutes of Aristotle’s physics to the relativity of Galileo’s principle of inertia and to Einstein’s theory of relativity, shows that it has taken centuries to liberate us from the systematic errors, from the illusions caused by the immediate point of view as opposed to “decentered” systematic thinking.

In the history of physics, there have been three great revolutions in thought that first seemed absurd yet proved to be true. The first proposed that the earth, instead of being stationary, was moving around at a great and variable speed in a universe that is much bigger than it appears to our immediate perception. That proposal, I believe, was first made by Aristarchos two millenia ago ... Remarkably enough, the name Aristarchos in Greek means best beginning.
[The next two revolutions occurred ... in the early part of the twentieth century: the theory of relativity and the science of quantum mechanics...]

It is entirely unprecedented that evolution should provide a species with an organ which it does not know how to use. … But the evolution of man’s brain has so wildly overshot man’s immediate needs that he is still breathlessly catching up with its unexploited, unexplored possibilities.

It is therefore easy to see why the churches have always fought science and persecuted its devotees. On the other hand, I maintain that the cosmic religious feeling is the strongest and noblest motive for scientific research. Only those who realize the immense efforts and, above all, the devotion without which pioneer work in theoretical science cannot be achieved are able to grasp the strength of the emotion out of which alone such work, remote as it is from the immediate realities of life, can issue. What a deep conviction of the rationality of the universe and what a yearning to understand, were it but a feeble reflection of the mind revealed in this world, Kepler and Newton must have had to enable them to spend years of solitary labor in disentangling the principles of celestial mechanics! Those whose acquaintance with scientific research is derived chiefly from its practical results easily develop a completely false notion of the mentality of the men who, surrounded by a skeptical world, have shown the way to kindred spirits scattered wide through the world and through the centuries. Only one who has devoted his life to similar ends can have a vivid realization of what has inspired these men and given them the strength to remain true to their purpose in spite of countless failures. It is cosmic religious feeling that gives a man such strength. A contemporary has said, not unjustly, that in this materialistic age of ours the serious scientific workers are the only profoundly religious people.

It seems to me that the view toward which we are tending is that the specificity in gene action is always a chemical specificity, probably the production of enzymes which guide metabolic processes along particular channels. A given array of genes thus determines the production of a particular kind of protoplasm with particular properties—such, for example, as that of responding to surface forces by the formation of a special sort of semipermeable membrane, and that of responding to trivial asymmetries in the play of external stimuli by polarization, with consequent orderly quantitative gradients in all physiologic processes. Different genes may now be called into play at different points in this simple pattern, either through the local formation of their specific substrates for action, or by activation of a mutational nature. In either case the pattern becomes more complex and qualitatively differentiated. Successive interactions of differentiated regions and the calling into play of additional genes may lead to any degree of complexity of pattern in the organism as a largely self-contained system. The array of genes, assembled in the course of evolution, must of course be one which determines a highly self­regulatory system of reactions. On this view the genes are highly specific chemically, and thus called into play only under very specific conditions; but their morphological effects, if any, rest on quantitative influences of immediate or remote products on growth gradients, which are resultants of all that has gone on before in the organism.

Its immediate significance was as a currency, for it closed the triangle linking spirits, slaves, and sugar. Rum could be used to buy slaves, with which to produce sugar, the leftovers of which could be made into rum to buy more slaves, and so on and on.

Knowledge does not keep any better than fish. You may be dealing with knowledge of the old species, with some old truth; but somehow or other it must come to the students, as it were, just drawn out of the sea and with the freshness of its immediate importance.

Knowledge once gained casts a faint light beyond its own immediate boundaries. There is no discovery so limited as not to illuminate something beyond itself.

Mathematics has often been characterized as the most conservative of all sciences. This is true in the sense of the immediate dependence of new upon old results. All the marvellous new advancements presuppose the old as indispensable steps in the ladder. … Inaccessibility of special fields of mathematics, except by the regular way of logically antecedent acquirements, renders the study discouraging or hateful to weak or indolent minds.

Mathematics renders its best service through the immediate furthering of rigorous thought and the spirit of invention.

Mathematics, among all school subjects, is especially adapted to further clearness, definite brevity and precision in expression, although it offers no exercise in flights of rhetoric. This is due in the first place to the logical rigour with which it develops thought, avoiding every departure from the shortest, most direct way, never allowing empty phrases to enter. Other subjects excel in the development of expression in other respects: translation from foreign languages into the mother tongue gives exercise in finding the proper word for the given foreign word and gives knowledge of laws of syntax, the study of poetry and prose furnish fit patterns for connected presentation and elegant form of expression, composition is to exercise the pupil in a like presentation of his own or borrowed thoughtsand their development, the natural sciences teach description of natural objects, apparatus and processes, as well as the statement of laws on the grounds of immediate sense-perception. But all these aids for exercise in the use of the mother tongue, each in its way valuable and indispensable, do not guarantee, in the same manner as mathematical training, the exclusion of words whose concepts, if not entirely wanting, are not sufficiently clear. They do not furnish in the same measure that which the mathematician demands particularly as regards precision of expression.

Miss Stevens’s work is characterized by its precision, and by a caution that seldom ventures far from the immediate observation. Her contributions are models of brevity—a brevity amounting at times almost to meagerness.

Natural selection produces systems that function no better than necessary. It results in ad hoc adaptive solutions to immediate problems. Whatever enhances fitness is selected. The product of natural selection is not perfection but adequacy, not final answers but limited, short-term solutions.

Newton has shown us that a law is only a necessary relation between the present state of the world and its immediately subsequent state. All the other laws since discovered are nothing else; they are in sum, differential equations.

No excavation ought to ever be permitted except under the immediate eye of a responsible and trustworthy superintendent. ... Superfluous precision may be regarded as a fault on the right side. ... [P]ottery [i]s the human fossil, so widely is it distributed.
Some of the basic principals of digging he adopted.

No school subject so readily furnishes tasks whose purpose can be made so clear, so immediate and so appealing to the sober second-thought of the immature learner as the right sort of elementary school mathematics.

None but a naturalist can understand the intense excitement I experienced when I at length captured it [a hitherto unknown species of butterfly]. On taking it out of my net and opening the glorious wings, my heart began to beat, violently, the blood rushed to my head, and I felt much more like fainting than I have done when in apprehension of immediate death. I had a headache the rest of the day, so great was the excitement produced by what will appear to most people a very inadequate cause.

Now it came to me: … the independence of the gravitational acceleration from the nature of the falling substance, may be expressed as follows: In a gravitational field (of small spatial extension) things behave as they do in a space free of gravitation. … This happened in 1908. Why were another seven years required for the construction of the general theory of relativity? The main reason lies in the fact that it is not so easy to free oneself from the idea that coordinates must have an immediate metrical meaning.

One of the most immediate consequences of the electrochemical theory is the necessity of regarding all chemical compounds as binary substances. It is necessary to discover in each of them the positive and negative constituents... No view was ever more fitted to retard the progress of organic chemistry. Where the theory of substitution and the theory of types assume similar molecules, in which some of the elements can be replaced by others without the edifice becoming modified either in form or outward behaviour, the electrochemical theory divides these same molecules, simply and solely, it may be said, in order to find in them two opposite groups, which it then supposes to be combined with each other in virtue of their mutual electrical activity... I have tried to show that in organic chemistry there exist types which are capable, without destruction, of undergoing the most singular transformations according to the nature of the elements.

Our immediate interests are after all of but small moment. It is what we do for the future, what we add to the sum of man's knowledge, that counts most. As someone has said, 'The individual withers and the world is more and more.' Man dies at 70, 80, or 90, or at some earlier age, but through his power of physical reproduction, and with the means that he has to transmit the results of effort to those who come after him, he may be said to be immortal.

Overemphasis on the competitive system and premature specialization on the ground of immediate usefulness kill the spirit on which all cultural life depends.

People ask, “Is the science going to run ahead of the ethics?” I don't think that’s always the problem. I think it’s that the science runs ahead of the politics. Bioethics can alert people to something coming down the road, but it doesn't mean policy and politicians are going to pay attention. They tend to respond when there’s an immediate crisis. The job of the ethicist, in some ways, is to warn or be prophetic. You can yell loudly, but you can’t necessarily get everybody to leave the cinema, so to speak.

Poetry is not the proper antithesis to prose, but to science…. The proper and immediate object of science is the acquirement, or communication, of truth; the proper and immediate object of poetry is the communication of immediate pleasure.

Post-operatively the transplanted kidney functioned immediately with a dramatic improvement in the patient’s renal and cardiopulmonary status. This spectacular success was a clear demonstration that organ transplantation could be life-saving. In a way, it was spying into the future because we had achieved our long-term goal by bypassing, but not solving, the issue of biological incompatibility.

Proof that a given condition always precedes or accompanies a phenomenon does not warrant concluding with certainty that a given condition is the immediate cause of that phenomenon. It must still be established that when this condition is removed, the phenomen will no longer appear.

Science is complex and chilling. The mathematical language of science is understood by very few. The vistas it presents are scary—an enormous universe ruled by chance and impersonal rules, empty and uncaring, ungraspable and vertiginous. How comfortable to turn instead to a small world, only a few thousand years old, and under God's personal; and immediate care; a world in which you are His peculiar concern.

Science, in the immediate, produces knowledge and, indirectly, means of action. It leads to methodical action if definite goals are set up in advance. For the function of setting up goals and passing statements of value transcends its domain. While it is true that science, to the extent of its grasp of causative connections, may reach important conclusions as to the compatibility and incompatibility of goals and evaluations, the independent and fundamental definitions regarding goals and values remain beyond science’s reach.

So long as the fur of the beaver was extensively employed as a material for fine hats, it bore a very high price, and the chase of this quadruped was so keen that naturalists feared its speedy consideration. When a Parisian manufacturer invented the silk hat, which soon came into almost universal use, the demand for beavers' fur fell off, and this animal–whose habits, as we have seen, are an important agency in the formation of bogs and other modifications of forest nature–immediately began to increase, reappeared in haunts which we had long abandoned, and can no longer be regarded as rare enough to be in immediate danger of extirpation. Thus the convenience or the caprice of Parisian fashion has unconsciously exercised an influence which may sensibly affect the physical geography of a distant continent.

Some recent work by E. Fermi and L. Szilard, which has been communicated to me in manuscript, leads me to expect that the element uranium may be turned into a new and important source of energy in the immediate future. Certain aspects of the situation seem to call for watchfulness and, if necessary, quick action on the part of the Administration. …
In the course of the last four months it has been made probable … that it may become possible to set up nuclear chain reactions in a large mass of uranium, by which vast amounts of power and large quantities of new radium-like elements would be generated. Now it appears almost certain that this could be achieved in the immediate future.
This new phenomenon would also lead to the construction of bombs, and it is conceivable—though much less certain—that extremely powerful bombs of a new type may thus be constructed. A single bomb of this type, carried by boat or exploded in a port, might well destroy the whole port altogether with some of the surrounding territory. However, such bombs might well prove to be too heavy for transportation by air.

Suddenly there was an enormous explosion, like a violent volcano. The nuclear reactions had led to overheating in the underground burial grounds. The explosion poured radioactive dust and materials high up into the sky. It was just the wrong weather for such a tragedy. Strong winds blew the radioactive clouds hundreds of miles away. It was difficult to gauge the extent of the disaster immediately, and no evacuation plan was put into operation right away. Many villages and towns were only ordered to evacuate when the symptoms of radiation sickness were already quite apparent. Tens of thousands of people were affected, hundreds dying, though the real figures have never been made public. The large area, where the accident happened, is still considered dangerous and is closed to the public.

Suppose the results of a line of study are negative. It might save a lot of otherwise wasted money to know a thing won’t work. But how do you accurately evaluate negative results? ... The power plant in [the recently developed streamline trains] is a Diesel engine of a type which was tried out many [around 25] years ago and found to be a failure. … We didn’t know how to build them. The principle upon which it operated was sound. [Since then much has been] learned in metallurgy [and] the accuracy with which parts can be manufactured
When this type of engine was given another chance it was an immediate success [because now] an accuracy of a quarter of a tenth of a thousandth of an inch [prevents high-pressure oil leaks]. … If we had taken the results of past experience without questioning the reason for the first failure, we would never have had the present light-weight, high-speed Diesel engine which appears to be the spark that will revitalize the railroad business.

Taking advantage of the method, found by me, of the black staining of the elements of the brain, staining obtained by the prolonged immersion of the pieces, previously hardened with potassium or ammonium bichromate, in a 0.50 or 1.0% solution of silver nitrate, I happened to discover some facts concerning the structure of the cerebral gray matter that I believe merit immediate communication.

That the main results of the astronomer’s work are not so immediately practical does not detract from their value. They are, I venture to think, the more to be prized on that account. Astronomy has profoundly influenced the thought of the race. In fact, it has been the keystone in the arch of the sciences under which we have marched out from the darkness of the fifteenth and preceding centuries to the comparative light of to-day.

The biologist can push it back to the original protist, and the chemist can push it back to the crystal, but none of them touch the real question of why or how the thing began at all. The astronomer goes back untold million of years and ends in gas and emptiness, and then the mathematician sweeps the whole cosmos into unreality and leaves one with mind as the only thing of which we have any immediate apprehension. Cogito ergo sum, ergo omnia esse videntur. All this bother, and we are no further than Descartes. Have you noticed that the astronomers and mathematicians are much the most cheerful people of the lot? I suppose that perpetually contemplating things on so vast a scale makes them feel either that it doesn’t matter a hoot anyway, or that anything so large and elaborate must have some sense in it somewhere.

The explorations of space end on a note of uncertainty. And necessarily so. … We know our immediate neighborhood rather intimately. With increasing distance our knowledge fades, and fades rapidly. Eventually, we reach the dim boundary—the utmost limits of our telescopes. There, we measure shadows, and we search among ghostly errors of measurement for landmarks that are scarcely more substantial. The search will continue. Not until the empirical resources are exhausted, need we pass on to the dreamy realms of speculation.

The great truths with which it [mathematics] deals, are clothed with austere grandeur, far above all purposes of immediate convenience or profit. It is in them that our limited understandings approach nearest to the conception of that absolute and infinite, towards which in most other things they aspire in vain. In the pure mathematics we contemplate absolute truths, which existed in the divine mind before the morning stars sang together, and which will continue to exist there, when the last of their radiant host shall have fallen from heaven. They existed not merely in metaphysical possibility, but in the actual contemplation of the supreme reason. The pen of inspiration, ranging all nature and life for imagery to set forth the Creator’s power and wisdom, finds them best symbolized in the skill of the surveyor. "He meted out heaven as with a span;" and an ancient sage, neither falsely nor irreverently, ventured to say, that “God is a geometer”.

The hybridoma technology was a by-product of basic research. Its success in practical applications is to a large extent the result of unexpected and unpredictable properties of the method. It thus represents another clear-cut example of the enormous practical impact of an investment in research which might not have been considered commercially worthwhile, or of immediate medical relevance. It resulted from esoteric speculations, for curiosity’s sake, only motivated by a desire to understand nature.

The immediate object of all art is either pleasure or utility: the immediate object of all science is solely truth.

The incessant call in this country for practical results and the confounding of mechanical inventions with scientific discoveries has a very prejudicial influence on science. … A single scientific principle may include a thousand applications and is therefore though if not of immediate use of vastly more importance even in a practical view.

The man imbued with the proper spirit of science does not seek for immediate pecuniary reward from the practical applications of his discoveries, but derives sufficient gratification from his pursuit and the consciousness of enlarging the bounds of human contemplation, and the magnitude of human power, and leaves to others to gather the golden fruit he may strew along his pathway.

The opinion I formed from attentive observation of the facts and phenomena, is as follows. When ice, for example, or any other solid substance, is changing into a fluid by heat, I am of opinion that it receives a much greater quantity of heat than that what is perceptible in it immediately after by the thermometer. A great quantity of heat enters into it, on this occasion, without making it apparently warmer, when tried by that instrument. This heat, however, must be thrown into it, in order to give it the form of a fluid; and I affirm, that this great addition of heat is the principal, and most immediate cause of the fluidity induced. And, on the other hand, when we deprive such a body of its fluidity again, by a diminution of its heat, a very great quantity of heat comes out of it, while it is assuming a solid form, the loss of which heat is not to be perceived by the common manner of using the thermometer. The apparent heat of the body, as measured by that instrument, is not diminished, or not in proportion to the loss of heat which the body actually gives out on this occasion; and it appears from a number of facts, that the state of solidity cannot be induced without the abstraction of this great quantity of heat. And this confirms the opinion, that this quantity of heat, absorbed, and, as it were, concealed in the composition of fluids, is the most necessary and immediate cause of their fluidity.

The preservation of a few samples of undeveloped territory is one of the most clamant issues before us today. Just a few more years of hesitation and the only trace of that wilderness which has exerted such a fundamental influence in molding American character will lie in the musty pages of pioneer books. … To avoid this catastrophe demands immediate action.

The responsibility for maintaining the composition of the blood in respect to other constituents devolves largely upon the kidneys. It is no exaggeration to say that the composition of the blood is determined not by what the mouth ingests but by what the kidneys keep; they are the master chemists of our internal environment, which, so to speak, they synthesize in reverse. When, among other duties, they excrete the ashes of our body fires, or remove from the blood the infinite variety of foreign substances which are constantly being absorbed from our indiscriminate gastrointestinal tracts, these excretory operations are incidental to the major task of keeping our internal environment in an ideal, balanced state. Our glands, our muscles, our bones, our tendons, even our brains, are called upon to do only one kind of physiological work, while our kidneys are called upon to perform an innumerable variety of operations. Bones can break, muscles can atrophy, glands can loaf, even the brain can go to sleep, without immediately endangering our survival, but when the kidneys fail to manufacture the proper kind of blood neither bone, muscle, gland nor brain can carry on.

The ridge of the Lammer-muir hills... consists of primary micaceous schistus, and extends from St Abb's head westward... The sea-coast affords a transverse section of this alpine tract at its eastern extremity, and exhibits the change from the primary to the secondary strata... Dr HUTTON wished particularly to examine the latter of these, and on this occasion Sir JAMES HALL and I had the pleasure to accompany him. We sailed in a boat from Dunglass ... We made for a high rocky point or head-land, the SICCAR ... On landing at this point, we found that we actually trode [sic] on the primeval rock... It is here a micaceous schistus, in beds nearly vertical, highly indurated, and stretching from S.E. to N. W. The surface of this rock... has thin covering of red horizontal sandstone laid over it, ... Here, therefore, the immediate contact of the two rocks is not only visible, but is curiously dissected and laid open by the action of the waves... On us who saw these phenomena for the first time, the impression will not easily be forgotten. The palpable evidence presented to us, of one of the most extraordinary and important facts in the natural history of the earth, gave a reality and substance to those theoretical speculations, which, however probable had never till now been directly authenticated by the testimony of the senses... What clearer evidence could we have had of the different formation of these rocks, and of the long interval which separated their formation, had we actually seen them emerging from the bosom of the deep? ... The mind seemed to grow giddy by looking so far into the abyss of time; and while we listened with earnestness and admiration to the philosopher who was now unfolding to us the order and series of these wonderful events, we became sensible how much farther reason may sometimes go than imagination can venture to follow.

The science of constructing a commonwealth, or renovating it, or reforming it, is, like every other experimental science, not to be taught a priori. Nor is it a short experience that can instruct us in that practical science, because the real effects of moral causes are not always immediate.

The scientific man does not aim at an immediate result. He does not expect that his advanced ideas will be readily taken up. His work is like that of the planter—for the future. His duty is to lay the foundation for those who are to come, and point the way.

The symbol A is not the counterpart of anything in familiar life. To the child the letter A would seem horribly abstract; so we give him a familiar conception along with it. “A was an Archer who shot at a frog.” This tides over his immediate difficulty; but he cannot make serious progress with word-building so long as Archers, Butchers, Captains, dance round the letters. The letters are abstract, and sooner or later he has to realise it. In physics we have outgrown archer and apple-pie definitions of the fundamental symbols. To a request to explain what an electron really is supposed to be we can only answer, “It is part of the A B C of physics”.

The technologies which have had the most profound effects on human life are usually simple. A good example of a simple technology with profound historical consequences is hay. Nobody knows who invented hay, the idea of cutting grass in the autumn and storing it in large enough quantities to keep horses and cows alive through the winter. All we know is that the technology of hay was unknown to the Roman Empire but was known to every village of medieval Europe. Like many other crucially important technologies, hay emerged anonymously during the so-called Dark Ages. According to the Hay Theory of History, the invention of hay was the decisive event which moved the center of gravity of urban civilization from the Mediterranean basin to Northern and Western Europe. The Roman Empire did not need hay because in a Mediterranean climate the grass grows well enough in winter for animals to graze. North of the Alps, great cities dependent on horses and oxen for motive power could not exist without hay. So it was hay that allowed populations to grow and civilizations to flourish among the forests of Northern Europe. Hay moved the greatness of Rome to Paris and London, and later to Berlin and Moscow and New York. ... Great inventions like hay and printing, whatever their immediate social costs may be, result in a permanent expansion of our horizons, a lasting acquisition of new territory for human bodies and minds to cultivate.

The theory here developed is that mega-evolution normally occurs among small populations that become preadaptive and evolve continuously (without saltation, but at exceptionally rapid rates) to radically different ecological positions. The typical pattern involved is probably this: A large population is fragmented into numerous small isolated lines of descent. Within these, inadaptive differentiation and random fixation of mutations occur. Among many such inadaptive lines one or a few are preadaptive, i.e., some of their characters tend to fit them for available ecological stations quite different from those occupied by their immediate ancestors. Such groups are subjected to strong selection pressure and evolve rapidly in the further direction of adaptation to the new status. The very few lines that successfully achieve this perfected adaptation then become abundant and expand widely, at the same time becoming differentiated and specialized on lower levels within the broad new ecological zone.

The White medullary Substance of the Brain is also the immediate Instrument, by which Ideas are presented to the Mind: Or, in other Words, whatever Changes are made in this Substance, corresponding Changes are made in our Ideas; and vice versa.

There are two processes which we adopt consciously or unconsciously when we try to prophesy. We can seek a period in the past whose conditions resemble as closely as possible those of our day, and presume that the sequel to that period will, save for some minor alterations, be similar. Secondly, we can survey the general course of development in our immediate past, and endeavor to prolong it into the near future. The first is the method the historian; the second that of the scientist. Only the second is open to us now, and this only in a partial sphere.

These expert men, technologists, engineers, or whatever name may best suit them, make up the indispensable General staff of the industrial system; and without their immediate and unremitting guidance and correction the industrial system will not work. It is a mechanically organized structure of technical processes designed, installed, and conducted by these production engineers. Without them and their constant attention the industrial equipment, the mechanical appliances of industry, will foot up to just so much junk.

Time ends. That is the lesson of the “big bang”. It is also the lesson of the black hole, closer at hand and more immediate object of study. The black hole is a completely collapsed object. It is mass without matter. The Cheshire cat in Alice in Wonderland faded away leaving behind only its grin. A star that falls into an already existing black hole, or that collapses to make a new black hole, fades away. Of the star, of its matter and of its sunspots and solar prominences, all trace disappears. There remains behind only gravitational attraction, the attraction of disembodied mass.

Timorous readers, however, need entertain no feverish fear, on, visiting the Isle of Sheppey, of encountering either wild elephants, crocodiles, sharks, serpents, or man-eating birds of huge dimensions, bearing strange names, and armed with sets of teeth for masticating and digestive purposes, as the author can assure them that they all died out a million or so of years ago, before he undertook to look up their records and write the history of this wonderful little island. Visitors may, however, honestly deplore the absence of the feathery palm trees bearing the luscious date and the lacteous cocoa-nut; but by prosecuting a diligent search they may, at least, be consoled by procuring some of these, rare fossil remains, reminiscent of an incalculable period of time when our particular portion of this hemisphere performed its diurnal revolutions in the immediate zone of the tropics.

To him who devotes his life to science, nothing can give more happiness than increasing the number of discoveries, but his cup of joy is full when the results of his studies immediately find practical applications.

To prove to an indignant questioner on the spur of the moment that the work I do was useful seemed a thankless task and I gave it up. I turned to him with a smile and finished, “To tell you the truth we don’t do it because it is useful but because it’s amusing.” The answer was thought of and given in a moment: it came from deep down in my soul, and the results were as admirable from my point of view as unexpected. My audience was clearly on my side. Prolonged and hearty applause greeted my confession. My questioner retired shaking his head over my wickedness and the newspapers next day, with obvious approval, came out with headlines “Scientist Does It Because It’s Amusing!” And if that is not the best reason why a scientist should do his work, I want to know what is. Would it be any good to ask a mother what practical use her baby is? That, as I say, was the first evening I ever spent in the United States and from that moment I felt at home. I realised that all talk about science purely for its practical and wealth-producing results is as idle in this country as in England. Practical results will follow right enough. No real knowledge is sterile. The most useless investigation may prove to have the most startling practical importance: Wireless telegraphy might not yet have come if Clerk Maxwell had been drawn away from his obviously “useless” equations to do something of more practical importance. Large branches of chemistry would have remained obscure had Willard Gibbs not spent his time at mathematical calculations which only about two men of his generation could understand. With this faith in the ultimate usefulness of all real knowledge a man may proceed to devote himself to a study of first causes without apology, and without hope of immediate return.

To what purpose should People become fond of the Mathematicks and Natural Philosophy? … People very readily call Useless what they do not understand. It is a sort of Revenge… One would think at first that if the Mathematicks were to be confin’d to what is useful in them, they ought only to be improv'd in those things which have an immediate and sensible Affinity with Arts, and the rest ought to be neglected as a Vain Theory. But this would be a very wrong Notion. As for Instance, the Art of Navigation hath a necessary Connection with Astronomy, and Astronomy can never be too much improv'd for the Benefit of Navigation. Astronomy cannot be without Optics by reason of Perspective Glasses: and both, as all parts of the Mathematicks are grounded upon Geometry … .

Today it is no longer questioned that the principles of the analysts are the more far-reaching. Indeed, the synthesists lack two things in order to engage in a general theory of algebraic configurations: these are on the one hand a definition of imaginary elements, on the other an interpretation of general algebraic concepts. Both of these have subsequently been developed in synthetic form, but to do this the essential principle of synthetic geometry had to be set aside. This principle which manifests itself so brilliantly in the theory of linear forms and the forms of the second degree, is the possibility of immediate proof by means of visualized constructions.

True physics was founded the day when Galileo, rejecting fruitless speculations, conceived the idea … of defining the general form to give to experiments, by assigning for their immediate purpose the measure of all that can be measurable in natural phenomena.

We all know, from what we experience with and within ourselves, that our conscious acts spring from our desires and our fears. Intuition tells us that that is true also of our fellows and of the higher animals. We all try to escape pain and death, while we seek what is pleasant. We are all ruled in what we do by impulses; and these impulses are so organized that our actions in general serve for our self preservation and that of the race. Hunger, love, pain, fear are some of those inner forces which rule the individual’s instinct for self preservation. At the same time, as social beings, we are moved in the relations with our fellow beings by such feelings as sympathy, pride, hate, need for power, pity, and so on. All these primary impulses, not easily described in words, are the springs of man’s actions. All such action would cease if those powerful elemental forces were to cease stirring within us. Though our conduct seems so very different from that of the higher animals, the primary instincts are much alike in them and in us. The most evident difference springs from the important part which is played in man by a relatively strong power of imagination and by the capacity to think, aided as it is by language and other symbolical devices. Thought is the organizing factor in man, intersected between the causal primary instincts and the resulting actions. In that way imagination and intelligence enter into our existence in the part of servants of the primary instincts. But their intervention makes our acts to serve ever less merely the immediate claims of our instincts.

We build our personalities laboriously and through many years, and we cannot order fundamental changes just because we might value their utility; no button reading ‘positive attitude’ protrudes from our hearts, and no finger can coerce positivity into immediate action by a single and painless pressing.

We cannot expect in the immediate future that all women who seek it will achieve full equality of opportunity. But if women are to start moving towards that goal, we must believe in ourselves or no one else will believe in us; we must match our aspirations with the competence, courage and determination to succeed.

We shall therefore say that a program has common sense if it automatically deduces for itself a sufficient wide class of immediate consequences of anything it is told and what it already knows. ... Our ultimate objective is to make programs that learn from their experience as effectively as humans do.

We should stop the non-scientific, pseudo-scientific, and anti-scientific nonsense emanating from the right wing, and start demanding immediate action to reduce global warming and prevent catastrophic climate change that may be on our horizon now. We must not let the [Bush] Administration distort science and rewrite and manipulate scientific reports in other areas. We must not let it turn the Environmental Protection Agency into the Environmental Pollution Agency.

What about the magical number seven? What about the seven wonders of the world, the seven seas, the seven deadly sins, the seven daughters of Atlas in the Pleiades, the seven ages of man, the seven levels of hell, the seven primary colors, the seven notes of the musical scale, and the seven days of the week? What about the seven-point rating scale, the seven categories for absolute judgment, the seven objects in the span of attention, and the seven digits in the span of immediate memory? For the present I propose to withhold judgment. Perhaps there is something deep and profound behind all these sevens, something just calling out for us to discover it. But I suspect that it is only a pernicious, Pythagorean coincidence.

Whatever be the detail with which you cram your student, the chance of his meeting in after life exactly that detail is almost infinitesimal; and if he does meet it, he will probably have forgotten what you taught him about it. The really useful training yields a comprehension of a few general principles with a thorough grounding in the way they apply to a variety of concrete details. In subsequent practice the men will have forgotten your particular details; but they will remember by an unconscious common sense how to apply principles to immediate circumstances. Your learning is useless to you till you have lost your textbooks, burnt your lecture notes, and forgotten the minutiae which you learned by heart for the examination. What, in the way of detail, you continually require will stick in your memory as obvious facts like the sun and the moon; and what you casually require can be looked up in any work of reference. The function of a University is to enable you to shed details in favor of principles. When I speak of principles I am hardly even thinking of verbal formulations. A principle which has thoroughly soaked into you is rather a mental habit than a formal statement. It becomes the way the mind reacts to the appropriate stimulus in the form of illustrative circumstances. Nobody goes about with his knowledge clearly and consciously before him. Mental cultivation is nothing else than the satisfactory way in which the mind will function when it is poked up into activity.

When Cayley had reached his most advanced generalizations he proceeded to establish them directly by some method or other, though he seldom gave the clue by which they had first been obtained: a proceeding which does not tend to make his papers easy reading. …
His literary style is direct, simple and clear. His legal training had an influence, not merely upon his mode of arrangement but also upon his expression; the result is that his papers are severe and present a curious contrast to the luxuriant enthusiasm which pervades so many of Sylvester’s papers. He used to prepare his work for publication as soon as he carried his investigations in any subject far enough for his immediate purpose. … A paper once written out was promptly sent for publication; this practice he maintained throughout life. … The consequence is that he has left few arrears of unfinished or unpublished papers; his work has been given by himself to the world.

Whoever, in the pursuit of science, seeks after immediate practical utility, may generally rest assured that he will seek in vain.

Without theory, practice is but routine born of habit. Theory alone can bring forth and develop the spirit of invention. ... [Do not] share the opinion of those narrow minds who disdain everything in science which has not an immediate application. ... A theoretical discovery has but the merit of its existence: it awakens hope, and that is all. But let it be cultivated, let it grow, and you will see what it will become.