A poet is, after all, a sort of scientist, but engaged in a qualitative science in which nothing is measurable. He lives with data that cannot be numbered, and his experiments can be done only once. The information in a poem is, by definition, not reproducible. ... He becomes an equivalent of scientist, in the act of examining and sorting the things popping in [to his head], finding the marks of remote similarity, points of distant relationship, tiny irregularities that indicate that this one is really the same as that one over there only more important. Gauging the fit, he can meticulously place pieces of the universe together, in geometric configurations that are as beautiful and balanced as crystals.

An amino acid residue (other than glycine) has no symmetry elements. The general operation of conversion of one residue of a single chain into a second residue equivalent to the first is accordingly a rotation about an axis accompanied by translation along the axis. Hence the only configurations for a chain compatible with our postulate of equivalence of the residues are helical configurations.
[Co-author with American chemist, ert B. Corey (1897-1971) and H. R. Branson]

It [mathematics] is in the inner world of pure thought, where all entia dwell, where is every type of order and manner of correlation and variety of relationship, it is in this infinite ensemble of eternal verities whence, if there be one cosmos or many of them, each derives its character and mode of being,—it is there that the spirit of mathesis has its home and its life.
Is it a restricted home, a narrow life, static and cold and grey with logic, without artistic interest, devoid of emotion and mood and sentiment? That world, it is true, is not a world of solar light, not clad in the colours that liven and glorify the things of sense, but it is an illuminated world, and over it all and everywhere throughout are hues and tints transcending sense, painted there by radiant pencils of psychic light, the light in which it lies. It is a silent world, and, nevertheless, in respect to the highest principle of art—the interpenetration of content and form, the perfect fusion of mode and meaning—it even surpasses music. In a sense, it is a static world, but so, too, are the worlds of the sculptor and the architect. The figures, however, which reason constructs and the mathematic vision beholds, transcend the temple and the statue, alike in simplicity and in intricacy, in delicacy and in grace, in symmetry and in poise. Not only are this home and this life thus rich in aesthetic interests, really controlled and sustained by motives of a sublimed and supersensuous art, but the religious aspiration, too, finds there, especially in the beautiful doctrine of invariants, the most perfect symbols of what it seeks—the changeless in the midst of change, abiding things hi a world of flux, configurations that remain the same despite the swirl and stress of countless hosts of curious transformations.

It has been recognized that hydrogen bonds restrain protein molecules to their native configurations, and I believe that as the methods of structural chemistry are further applied to physiological problems it will be found that the significance of the hydrogen bond for physiology is greater than that of any other single structural feature.

That mathematics “do not cultivate the power of generalization,”; … will be admitted by no person of competent knowledge, except in a very qualified sense. The generalizations of mathematics, are, no doubt, a different thing from the generalizations of physical science; but in the difficulty of seizing them, and the mental tension they require, they are no contemptible preparation for the most arduous efforts of the scientific mind. Even the fundamental notions of the higher mathematics, from those of the differential calculus upwards are products of a very high abstraction. … To perceive the mathematical laws common to the results of many mathematical operations, even in so simple a case as that of the binomial theorem, involves a vigorous exercise of the same faculty which gave us Kepler’s laws, and rose through those laws to the theory of universal gravitation. Every process of what has been called Universal Geometry—the great creation of Descartes and his successors, in which a single train of reasoning solves whole classes of problems at once, and others common to large groups of them—is a practical lesson in the management of wide generalizations, and abstraction of the points of agreement from those of difference among objects of great and confusing diversity, to which the purely inductive sciences cannot furnish many superior. Even so elementary an operation as that of abstracting from the particular configuration of the triangles or other figures, and the relative situation of the particular lines or points, in the diagram which aids the apprehension of a common geometrical demonstration, is a very useful, and far from being always an easy, exercise of the faculty of generalization so strangely imagined to have no place or part in the processes of mathematics.

The essential molecule of reproduction, DNA, … is composed of only four nitrogen bases (adenine, thymine, guanine, and cytosine), the sugar deoxyribose, and a phosphate. DNA’s intermediary, RNA, differs only by the substitution of the sugar ribose for deoxyribose and the nitrogen base uracil for thymine. The proteins of living organisms are made with a mere 20 amino acids, all arranged in a “left-handed” configuration. Taking into account all 28 building blocks, or “letters” (20 amino acids, five bases, two sugars, and one phosphate), the message is clear: With such a limited alphabet, all life must have had a common chemical origin.

Today it is no longer questioned that the principles of the analysts are the more far-reaching. Indeed, the synthesists lack two things in order to engage in a general theory of algebraic configurations: these are on the one hand a definition of imaginary elements, on the other an interpretation of general algebraic concepts. Both of these have subsequently been developed in synthetic form, but to do this the essential principle of synthetic geometry had to be set aside. This principle which manifests itself so brilliantly in the theory of linear forms and the forms of the second degree, is the possibility of immediate proof by means of visualized constructions.

While the biological properties of deoxypentose nucleic acid suggest a molecular structure containing great complexity, X-ray diffraction studies described here … show the basic molecular configuration has great simplicity. [Co-author with A.R. Stokes, H.R. Wilson. Thanks include to “… our colleagues R.E. Franklin, R.G. Gosling … for discussion.”]