…indeed what reason may not go to Schoole to the wisdome of Bees, Aunts, and Spiders? what wise hand teacheth them to doe what reason cannot teach us? Ruder heads stand amazed at those prodigious pieces of nature, Whales, Elephants, Dromidaries and Camels; these I confesse, are the Colossus and Majestick pieces of her hand; but in these narrow Engines there is more curious Mathematicks, and the civilitie of these little Citizens more neatly sets forth the wisedome of their Maker.

…this discussion would be unprofitable if it did not lead us to appreciate the wisdom of our Creator, and the wondrous knowledge of the Author of the world, Who in the beginning created the world out of nothing, and set everything in number, measure and weight, and then, in time and the age of man, formulated a science which reveals fresh wonders the more we study it.

“Facts” are the bounds of human knowledge, set for it, not by it.

[An audience conditioned by a lifetime of television-watching is so corrupted that] their standards have been systematically lowered over the years. These guys sit in front of their sets and the gamma rays eat the white cells of their brains out!

[Cantor’s set theory:] The finest product of mathematical genius and one of the supreme achievements of purely intellectual human activity.

[Certain students] suppose that because science has penetrated the structure of the atom it can solve all the problems of the universe. ... They are known in every ... college as the most insufferable, cocksure know-it-alls. If you want to talk to them about poetry, they are likely to reply that the "emotive response" to poetry is only a conditioned reflex .... If they go on to be professional scientists, their sharp corners are rubbed down, but they undergo no fundamental change. They most decidedly are not set apart from the others by their intellectual integrity and faith, and their patient humility in front of the facts of nature.... They are uneducated, in the fullest sense of the word, and they certainly are no advertisement for the claims of science teachers.

[Isaac Newton] regarded the Universe as a cryptogram set by the Almighty—just as he himself wrapt the discovery of the calculus in a cryptogram when he communicated with Leibniz. By pure thought, by concentration of mind, the riddle, he believed, would be revealed to the initiate.

[Mathematics is] the study of the measurement, properties, and relationships of quantities and sets, using numbers and symbols.

[Technical courage means the] physician-scientist must be brave enough to adopt new methods. It is far too easy to learn one technique and then to repeat the same experiment over and over. In this fashion one can write many papers, receive large research grants, and remain solidly rooted in the middle of a scientific field. But the true innovator has the confidence to drop one set of experimental crutches and leap to another when he or she must move forward.

[To the cultures of Asia and the continent of Africa] it is the Western impact which has stirred up the winds of change and set the processes of modernization in motion. Education brought not only the idea of equality but also another belief which we used to take for granted in the West—the idea of progress, the idea that science and technology can be used to better human conditions. In ancient society, men tended to believe themselves fortunate if tomorrow was not worse than today and anyway, there was little they could do about it.

[Walter] Baade, like all scientists of substance, had a set view of how things were put together, to be sure a view to be always challenged by the scientist himself, but defended as well against all less informed mortals who objected without simon-pure reasons.

A l’aide de ces sciences expérimentales actives, l’homme devient un inventeur de phénomènes, un véritable contremaître de la création; et l'on ne saurait, sous ce rapport, assigner de limites à la puissance qu’il peut acquérir sur la nature, par les progrès futurs des sciences expérimentales
With the aid of these active experimental sciences man becomes an inventor of phenomena, a real foreman of creation; and under this head we cannot set limits to the power that he may gain over nature through future progress of the experimental sciences.

Ath. There still remain three studies suitable for freemen. Calculation in arithmetic is one of them; the measurement of length, surface, and depth is the second; and the third has to do with the revolutions of the stars in reference to one another … there is in them something that is necessary and cannot be set aside, … if I am not mistaken, [something of] divine necessity; for as to the human necessities of which men often speak when they talk in this manner, nothing can be more ridiculous than such an application of the words.
Cle. And what necessities of knowledge are there, Stranger, which are divine and not human?
Ath. I conceive them to be those of which he who has no use nor any knowledge at all cannot be a god, or demi-god, or hero to mankind, or able to take any serious thought or charge of them.

Ich have auf eine geringe Vermutung eine gefährliche Reise gewagt und erblicke schon die Vorgebirge neuer Länder. Diejenigen, welche die Herzhaftigheit haben die Untersuchung fortzusetzen, werden sie betreten.
Upon a slight conjecture [on the origin of the solar system] I have ventured on a dangerous journey and I already behold the foothills of new lands. Those who have the courage to continue the search will set foot on them.

La chaleur pénètre, comme la gravité, toutes les substances de l’univers, ses rayons occupent toutes les parties de l’espace. Le but de notre ouvrage est d’exposer les lois mathématiques que suit cet élément. Cette théorie formera désormais une des branches les plus importantes de la physique générale.
Heat, like gravity, penetrates every substance of the universe, its rays occupy all parts of space. The object of our work is to set forth the mathematical laws which this element obeys. The theory of heat will hereafter form one of the most important branches of general physics.

Socrates: Shall we set down astronomy among the objects of study? Glaucon: I think so, to know something about the seasons, the months and the years is of use for military purposes, as well as for agriculture and for navigation. Socrates: It amuses me to see how afraid you are, lest the common herd of people should accuse you of recommending useless studies.

Ueber den Glauben lässt sich wissenschaftlich nicht rechten, denn die Wissenschaft und der Glaube schliessen sich aus. Nicht so, dass der eine die andere unmöglich machte oder umgekehrt, sondern so, dass, soweit die Wissenschaft reicht, kein Glaube existirt und der Glaube erst da anfangen darf, wo die Wissenschaft aufhört. Es lässt „sich nicht läugnen, dass, wenn diese Grenze eingehalten wird, der Glaube wirklich reale Objekte haben kann. Die Aufgabe der Wissenschaft ist es daher nicht, die Gegenstände des Glaubens anzugreifen, sondern nur die Grenzen zu stecken, welche die Erkenntniss erreichen kann, und innerhalb derselben das einheitliche Selbstbewusstsein zu begründen.
There is no scientific justification for faith, for science and faith are mutually exclusive. Not that one made the other impossible, or vice versa, but that, as far as science goes, there is no faith, and faith can only begin where science ends. It can not be denied that, if this limit is adhered to, faith can really have real objects. The task of science, therefore, is not to attack the objects of faith, but merely to set the limits which knowledge can attain and to establish within it the unified self-esteem.

~~[No known source]~~ Later generations will regard Mengenlehre [set theory] as a disease from which one has recovered.

A carriage (steam) will set out from Washington in the morning, the passengers will breakfast at Baltimore, dine at Philadelphia, and sup in New York the same day.

A conflict arises when a religious community insists on the absolute truthfulness of all statements recorded in the Bible. This means an intervention on the part of religion into the sphere of science; this is where the struggle of the Church against the doctrines of Galileo and Darwin belongs. On the other hand, representatives of science have often made an attempt to arrive at fundamental judgments with respect to values and ends on the basis of scientific method, and in this way have set themselves in opposition to religion. These conflicts have all sprung from fatal errors.

A fateful process is set in motion when the individual is released “to the freedom of his own impotence” and left to justify his existence by his own efforts. The autonomous individual, striving to realize himself and prove his worth, has created all that is great in literature, art, music, science and technology. The autonomous individual, also, when he can neither realize himself nor justify his existence by his own efforts, is a breeding call of frustration, and the seed of the convulsions which shake our world to its foundations.

A fractal is a mathematical set or concrete object that is irregular or fragmented at all scales.

A human being should be able to change a diaper, plan an invasion, butcher a hog, conn a ship, design a building, write a sonnet, balance accounts, build a wall, set a bone, comfort the dying, take orders, give orders, cooperate, act alone, solve equations, analyze a new problem, pitch manure, program a computer, cook a tasty meal, fight efficiently, die gallantly. Specialization is for insects.

A laboratory is only a place where one may better set up and control conditions.

A layman will no doubt find it hard to understand how pathological disorders of the body and mind can be eliminated by 'mere' words. He will feel that he is being asked to believe in magic. And he will not be so very wrong, for the words which we use in our everyday speech are nothing other than watered-down magic. But we shall have to follow a roundabout path in order to explain how science sets about restoring to words a part at least of their former magical power.

A linguist would be shocked to learn that if a set is not closed this does not mean that it is open, or again that “E is dense in E” does not mean the same thing as “E is dense in itself”.

A man who sets out to justify his existence and his activities has to distinguish two different questions. The first is whether the work which he does is worth doing; and the second is why he does it (whatever its value may be).

A mathematical science is any body of propositions which is capable of an abstract formulation and arrangement in such a way that every proposition of the set after a certain one is a formal logical consequence of some or all the preceding propositions. Mathematics consists of all such mathematical sciences.

A propos of Distempers, I am going to tell you a thing that I am sure will make you wish your selfe here. The Small Pox so fatal and so general amongst us is here entirely harmless by the invention of engrafting (which is the term they give it). There is a set of old Women who make it their business to perform the Operation.

A schism has taken place among the chemists. A particular set of them in France have undertaken to remodel all the terms of the science, and to give every substance a new name, the composition, and especially the termination of which, shall define the relation in which it stands to other substances of the same family, But the science seems too much in its infancy as yet, for this reformation; because in fact, the reformation of this year must be reformed again the next year, and so on, changing the names of substances as often as new experiments develop properties in them undiscovered before. The new nomenclature has, accordingly, been already proved to need numerous and important reformations. ... It is espoused by the minority here, and by the very few, indeed, of the foreign chemists. It is particularly rejected in England.

A set is a Many that allows itself to be thought of as a One.

A very interesting set of compounds that were waiting for the right disease.
[Commenting on AZT and similar drugs he had synthesized.]

A weird happening has occurred in the case of a lansquenet named Daniel Burghammer, of the squadron of Captain Burkhard Laymann Zu Liebenau, of the honorable Madrucci Regiment in Piadena, in Italy. When the same was on the point of going to bed one night he complained to his wife, to whom he had been married by the Church seven years ago, that he had great pains in his belly and felt something stirring therein. An hour thereafter he gave birth to a child, a girl. When his wife was made aware of this, she notified the occurrence at once. Thereupon he was examined and questioned. … He confessed on the spot that he was half man and half woman and that for more than seven years he had served as a soldier in Hungary and the Netherlands… . When he was born he was christened as a boy and given in baptism the name of Daniel… . He also stated that while in the Netherlands he only slept once with a Spaniard, and he became pregnant therefrom. This, however, he kept a secret unto himself and also from his wife, with whom he had for seven years lived in wedlock, but he had never been able to get her with child… . The aforesaid soldier is able to suckle the child with his right breast only and not at all on the left side, where he is a man. He has also the natural organs of a man for passing water. Both are well, the child is beautiful, and many towns have already wished to adopt it, which, however, has not as yet been arranged. All this has been set down and described by notaries. It is considered in Italy to be a great miracle, and is to be recorded in the chronicles. The couple, however, are to be divorced by the clergy.

About 6 or 8 years ago My Ingenious friend Mr John Robinson having [contrived] conceived that a fire engine might be made without a Lever—by Inverting the Cylinder & placing it above the mouth of the pit proposed to me to make a model of it which was set about by having never Compleated & I [being] having at that time Ignorant little knoledge of the machine however I always thought the Machine Might be applied to [more] other as valuable purposes [than] as drawing Water.

According to Herr Cook's observation, the inhabitants of New Guinea have something they set light to which burns up almost like gunpowder. They also put it into hollow staves, and from a distance you could believe they are shooting. But it does not produce so much as a bang. Presumably they are trying to imitate the Europeans. They have failed to realize its real purpose.

Again and again, often in the busiest phases of the insulin investigations, he [Frederick Banting] found time to set a fracture or perform a surgical operation on one of his army comrades or on some patient who was in need.

All material Things seem to have been composed of the hard and solid Particles … variously associated with the first Creation by the Counsel of an intelligent Agent. For it became him who created them to set them in order: and if he did so, it is unphilosophical to seek for any other Origin of the World, or to pretend that it might arise out of a Chaos by the mere Laws of Nature.

All science, even the divine science, is a sublime detective story. Only it is not set to detect why a man is dead; but the darker secret of why he is alive.

An evolution is a series of events that in itself as series is purely physical, — a set of necessary occurrences in the world of space and time. An egg develops into a chick; … a planet condenses from the fluid state, and develops the life that for millions of years makes it so wondrous a place. Look upon all these things descriptively, and you shall see nothing but matter moving instant after instant, each instant containing in its full description the necessity of passing over into the next. … But look at the whole appreciatively, historically, synthetically, as a musician listens to a symphony, as a spectator watches a drama. Now you shall seem to have seen, in phenomenal form, a story.

An Experiment, like every other event which takes place, is a natural phenomenon; but in a Scientific Experiment the circumstances are so arranged that the relations between a particular set of phenomena may be studied to the best advantage.

Anaximander son of Praxiades, of Miletus: he said that the principle and element is the Indefinite, not distinguishing air or water or anything else. … he was the first to discover a gnomon, and he set one up on the Sundials (?) in Sparta, according to Favorinus in his Universal History, to mark solstices and equinoxes; and he also constructed hour indicators. He was the first to draw an outline of earth and sea, but also constructed a [celestial] globe. Of his opinions he made a summary exposition, which I suppose Apollodorus the Athenian also encountered. Apollodorus says in his Chronicles that Anaximander was sixty-four years old in the year of the fifty-eighth Olympiad [547/6 B.C.], and that he died shortly afterwards (having been near his prime approximately during the time of Polycrates, tyrant of Samos).

And do you know what “the world” is to me? Shall I show it to you in my mirror? This world: a monster of energy, without beginning, without end; a firm, iron magnitude of force that does not grow bigger or smaller, that does not expend itself but only transforms itself; as a whole, of unalterable size, a household without expenses or losses, but likewise without increase or income; enclosed by “nothingness”' as by a boundary; not by something blurry or wasted, not something endlessly extended, but set in a definite space as a definite force, and not a space that might be “empty” here or there, but rather as force throughout, as a play of forces and waves of forces, at the same time one and many, increasing here and at the same time decreasing there; a sea of forces flowing and rushing together, eternally changing, eternally flooding back, with tremendous years of recurrence, with an ebb and a flood of its forms; out of the simplest forms striving toward the most complex, out of the stillest, most rigid, coldest forms toward the hottest, most turbulent, most self-contradictory, and then again returning home to the simple out of this abundance, out of the play of contradictions back to the joy of concord, still affirming itself in this uniformity of its courses and its years, blessing itself as that which must return eternally, as a becoming that knows no satiety, no disgust, no weariness: this, my Dionysian world of the eternally self-creating, the eternally self-destroying, this mystery world of the twofold voluptuous delight, my “beyond good and evil,” without goal, unless the joy of the circle itself is a goal; without will, unless a ring feels good will toward itself-do you want a name for this world? A solution for all its riddles? A light for you, too, you best-concealed, strongest, most intrepid, most midnightly men?—This world is the will to power—and nothing besides! And you yourselves are also this will to power—and nothing besides!

And from this such small difference of eight minutes [of arc] it is clear why Ptolemy, since he was working with bisection [of the linear eccentricity], accepted a fixed equant point… . For Ptolemy set out that he actually did not get below ten minutes [of arc], that is a sixth of a degree, in making observations. To us, on whom Divine benevolence has bestowed the most diligent of observers, Tycho Brahe, from whose observations this eight-minute error of Ptolemy’s in regard to Mars is deduced, it is fitting that we accept with grateful minds this gift from God, and both acknowledge and build upon it. So let us work upon it so as to at last track down the real form of celestial motions (these arguments giving support to our belief that the assumptions are incorrect). This is the path I shall, in my own way, strike out in what follows. For if I thought the eight minutes in [ecliptic] longitude were unimportant, I could make a sufficient correction (by bisecting the [linear] eccentricity) to the hypothesis found in Chapter 16. Now, because they could not be disregarded, these eight minutes alone will lead us along a path to the reform of the whole of Astronomy, and they are the matter for a great part of this work.

And having thus passed the principles of arithmetic, geometry, astronomy, and geography, with a general compact of physics, they may descend in mathematics to the instrumental science of trigonometry, and from thence to fortification, architecture, engineering, or navigation. And in natural philosophy they may proceed leisurely from the history of meteors, minerals, plants, and living creatures, as far as anatomy. Then also in course might be read to them out of some not tedious writer the institution of physic. … To set forward all these proceedings in nature and mathematics, what hinders but that they may procure, as oft as shall be needful, the helpful experiences of hunters, fowlers, fishermen, shepherds, gardeners, apothecaries; and in other sciences, architects, engineers, mariners, anatomists.

André Weil suggested that there is a logarithmic law at work: first-rate people attract other first-rate people, but second-rate people tend to hire third-raters, and third-rate people hire fifth-raters. If a dean or a president is genuinely interested in building and maintaining a high-quality university (and some of them are), then he must not grant complete self-determination to a second-rate department; he must, instead, use his administrative powers to intervene and set things right. That’s one of the proper functions of deans and presidents, and pity the poor university in which a large proportion of both the faculty and the administration are second-raters; it is doomed to diverge to minus infinity.

Another argument of hope may be drawn from this–that some of the inventions already known are such as before they were discovered it could hardly have entered any man's head to think of; they would have been simply set aside as impossible. For in conjecturing what may be men set before them the example of what has been, and divine of the new with an imagination preoccupied and colored by the old; which way of forming opinions is very fallacious, for streams that are drawn from the springheads of nature do not always run in the old channels.

Apart from its healthful mental training as a branch of ordinary education, geology as an open-air pursuit affords an admirable training in habits of observation, furnishes a delightful relief from the cares and routine of everyday life, takes us into the open fields and the free fresh face of nature, leads us into all manner of sequestered nooks, whither hardly any other occupation or interest would be likely to send us, sets before us problems of the highest interest regarding the history of the ground beneath our feet, and thus gives a new charm to scenery which may be already replete with attractions.

Artificial intelligence is based on the assumption that the mind can be described as some kind of formal system manipulating symbols that stand for things in the world. Thus it doesn't matter what the brain is made of, or what it uses for tokens in the great game of thinking. Using an equivalent set of tokens and rules, we can do thinking with a digital computer, just as we can play chess using cups, salt and pepper shakers, knives, forks, and spoons. Using the right software, one system (the mind) can be mapped onto the other (the computer).

As a scientist, I am not sure anymore that life can be reduced to a class struggle, to dialectical materialism, or any set of formulas. Life is spontaneous and it is unpredictable, it is magical. I think that we have struggled so hard with the tangible that we have forgotten the intangible.

As to the Christian religion, Sir, … there is a balance in its favor from the number of great men who have been convinced of its truth after a serious consideration of the question. Grotius was an acute man, a lawyer, a man accustomed to examine evidence, and he was convinced. Grotius was not a recluse, but a man of the world, who surely had no bias on the side of religion. Sir Isaac Newton set out an infidel, and came to be a very firm believer.

As, pricked out with less and greater lights, between the poles of the universe, the Milky Way so gleameth white as to set very sages questioning.

Ask why God made the GEM so small,
And why so huge the granite?
Because God meant, mankind should set
That higher value on it.

At fertilization, these two “haploid” nuclei are added together to make a “diploid” nucleus that now contains 2a, 2b and so on; and, by the splitting of each chromosome and the regulated karyokinetic separation of the daughter chromosomes, this double series is inherited by both of the primary blastomeres. In the resulting resting nuclei the individual chromosomes are apparently destroyed. But we have the strongest of indications that, in the stroma of the resting nucleus, every one of the chromosomes that enters the nucleus survives as a well-defined region; and as the cell prepares for its next division this region again gives rise to the same chromosome (Theory of the Individuality of the Chromosomes). In this way the two sets of chromosomes brought together at fertilization are inherited by all the cells of the new individual. It is only in the germinal cells that the so called reduction division converts the double series into a single one. Out of the diploid state, the haploid is once again generated.

At night I would return home, set out a lamp before me, and devote myself to reading and writing. Whenever sleep overcame me or I became conscious of weakening, I would turn aside to drink a cup of wine, so that my strength would return to me. Then I would return to reading. And whenever sleep seized me I would see those very problems in my dream; and many questions became clear to me in my sleep. I continued in this until all of the sciences were deeply rooted within me and I understood them as is humanly possible. Everything which I knew at the time is just as I know it now; I have not added anything to it to this day. Thus I mastered the logical, natural, and mathematical sciences, and I had now reached the science.

At the bidding of a Peter the Hermit many millions of men swarmed to the East; the words of an hallucinated person … have created the force necessary to triumph over the Graeco-Roman world; an obscure monk like Luther set Europe ablaze and bathed in blood. The voice of a Galileo or a Newton will never have the least echo among the masses. The inventors of genius transform a civilization. The fanatics and the hallucinated create history.

At the voice of comparative anatomy, every bone, and fragment of a bone, resumed its place. I cannot find words to express the pleasure I have in seeing, as I discovered one character, how all the consequences, which I predicted from it, were successively confirmed; the feet were found in accordance with the characters announced by the teeth; the teeth in harmony with those indicated beforehand by the feet; the bones of the legs and thighs, and every connecting portion of the extremities, were found set together precisely as I had arranged them, before my conjectures were verified by the discovery of the parts entire: in short, each species was, as it were, reconstructed from a single one of its component elements.

Atomic energy bears that same duality that has faced man from time immemorial, a duality expressed in the Book of Books thousands of years ago: “See, I have set before thee this day life and good and death and evil … therefore choose life.”

Be of good cheer. Do not think of today’s failures, but of the success that may come tomorrow. You have set yourself a difficult task, but you will succeed if you persevere; and you will find a joy in overcoming obstacles.

Before delivering your lectures, the manuscript should be in such a perfect form that, if need be, it could be set in type. Whether you follow the manuscript during the delivery of the lecture is purely incidental. The essential point is that you are thus master of the subject matter.

Behold the mighty dinosaur,
Famous in prehistoric lore,
Not only for his power and strength
But for his intellectual length.
You will observe by these remains
The creature had two sets of brains—
One in his head (the usual place),
The other at his spinal base.
Thus he could reason 'A priori'
As well as 'A posteriori'.
No problem bothered him a bit
He made both head and tail of it.
So wise was he, so wise and solemn,
Each thought filled just a spinal column.
If one brain found the pressure strong
It passed a few ideas along.
If something slipped his forward mind
'Twas rescued by the one behind.
And if in error he was caught
He had a saving afterthought.
As he thought twice before he spoke
He had no judgment to revoke.
Thus he could think without congestion
Upon both sides of every question.
Oh, gaze upon this model beast
Defunct ten million years at least.

Boundaries which mark off one field of science from another are purely artificial, are set up only for temporary convenience. Let chemists and physicists dig deep enough, and they reach common ground.

Bradley is one of the few basketball players who have ever been appreciatively cheered by a disinterested away-from-home crowd while warming up. This curious event occurred last March, just before Princeton eliminated the Virginia Military Institute, the year’s Southern Conference champion, from the NCAA championships. The game was played in Philadelphia and was the last of a tripleheader. The people there were worn out, because most of them were emotionally committed to either Villanova or Temple-two local teams that had just been involved in enervating battles with Providence and Connecticut, respectively, scrambling for a chance at the rest of the country. A group of Princeton players shooting basketballs miscellaneously in preparation for still another game hardly promised to be a high point of the evening, but Bradley, whose routine in the warmup time is a gradual crescendo of activity, is more interesting to watch before a game than most players are in play. In Philadelphia that night, what he did was, for him, anything but unusual. As he does before all games, he began by shooting set shots close to the basket, gradually moving back until he was shooting long sets from 20 feet out, and nearly all of them dropped into the net with an almost mechanical rhythm of accuracy. Then he began a series of expandingly difficult jump shots, and one jumper after another went cleanly through the basket with so few exceptions that the crowd began to murmur. Then he started to perform whirling reverse moves before another cadence of almost steadily accurate jump shots, and the murmur increased. Then he began to sweep hook shots into the air. He moved in a semicircle around the court. First with his right hand, then with his left, he tried seven of these long, graceful shots-the most difficult ones in the orthodoxy of basketball-and ambidextrously made them all. The game had not even begun, but the presumably unimpressible Philadelphians were applauding like an audience at an opera.

Bread has been made (indifferent) from potatoes;
And galvanism has set some corpses grinning,
But has not answer'd like the apparatus
Of the Humane Society's beginning,
By which men are unsuffocated gratis:
What wondrous new machines have late been spinning.

But when science, passing beyond its own limits, assumes to take the place of theology, and sets up its own conception of the order of Nature as a sufficient account of its cause, it is invading a province of thought to which it has no claim, and not unreasonably provokes the hostility of its best friends.

But without effort [God] sets in motion all things by mind and thought.

By relieving the brain of all unnecessary work, a good notation sets it free to concentrate on more advanced problems, and in effect increases the mental power of the race.

Chromosomes … [contain] some kind of code-script the entire pattern of the individual’s future development and of its functioning in the mature state. Every complete set of chromosomes contains the full code.

Concerning alchemy it is more difficult to discover the actual state of things, in that the historians who specialise in this field seem sometimes to be under the wrath of God themselves; for, like those who write of the Bacon-Shakespeare controversy or on Spanish politics, they seem to become tinctured with the kind of lunacy they set out to describe.

Consider the plight of a scientist of my age. I graduated from the University of California at Berkeley in 1940. In the 41 years since then the amount of biological information has increased 16 fold; during these 4 decades my capacity to absorb new information has declined at an accelerating rate and now is at least 50% less than when I was a graduate student. If one defines ignorance as the ratio of what is available to be known to what is known, there seems no alternative to the conclusion that my ignorance is at least 25 times as extensive as it was when I got my bachelor’s degree. Although I am sure that my unfortunate condition comes as no surprise to my students and younger colleagues, I personally find it somewhat depressing. My depression is tempered, however, by the fact that all biologists, young or old, developing or senescing, face the same melancholy situation because of an interlocking set of circumstances.

Contingency is rich and fascinating; it embodies an exquisite tension between the power of individuals to modify history and the intelligible limits set by laws of nature. The details of individual and species’s lives are not mere frills, without power to shape the large-scale course of events, but particulars that can alter entire futures, profoundly and forever.

Culture in its higher forms is a delicate plant which depends on a complicated set of conditions and is wont to flourish only in a few places at any given time.

Dissection … teaches us that the body of man is made up of certain kinds of material, so differing from each other in optical and other physical characters and so built up together as to give the body certain structural features. Chemical examination further teaches us that these kinds of material are composed of various chemical substances, a large number of which have this characteristic that they possess a considerable amount of potential energy capable of being set free, rendered actual, by oxidation or some other chemical change. Thus the body as a whole may, from a chemical point of view, be considered as a mass of various chemical substances, representing altogether a considerable capital of potential energy.

Do not let the sun rise upon a strangulated hernia if first seen at night; and do not let the sun set upon a strangulated hernia if first seen by day.

Doubtless the reasoning faculty, the mind, is the leading and characteristic attribute of the human race. By the exercise of this, man arrives at the properties of the natural bodies. This is science, properly and emphatically so called. It is the science of pure mathematics; and in the high branches of this science lies the truly sublime of human acquisition. If any attainment deserves that epithet, it is the knowledge, which, from the mensuration of the minutest dust of the balance, proceeds on the rising scale of material bodies, everywhere weighing, everywhere measuring, everywhere detecting and explaining the laws of force and motion, penetrating into the secret principles which hold the universe of God together, and balancing worlds against worlds, and system against system. When we seek to accompany those who pursue studies at once so high, so vast, and so exact; when we arrive at the discoveries of Newton, which pour in day on the works of God, as if a second fiat had gone forth from his own mouth; when, further, we attempt to follow those who set out where Newton paused, making his goal their starting-place, and, proceeding with demonstration upon demonstration, and discovery upon discovery, bring new worlds and new systems of worlds within the limits of the known universe, failing to learn all only because all is infinite; however we may say of man, in admiration of his physical structure, that “in form and moving he is express and admirable,” it is here, and here without irreverence, we may exclaim, “In apprehension how like a god!” The study of the pure mathematics will of course not be extensively pursued in an institution, which, like this [Boston Mechanics’ Institute], has a direct practical tendency and aim. But it is still to be remembered, that pure mathematics lie at the foundation of mechanical philosophy, and that it is ignorance only which can speak or think of that sublime science as useless research or barren speculation.

During my pre-college years I went on many trips with my father into the oil fields to visit their operations. … I puttered around the machine, electronics, and automobile shops while he carried on his business. Both of my parents are inveterate do-it-yourselfers, almost no task being beneath their dignity or beyond their ingenuity. Having picked up a keen interest in electronics from my father, I used to fix radios and later television sets for fun and spending money. I built my own hi-fi set and enjoyed helping friends with their amateur radio transmitters, but lost interest as soon as they worked.

Each species has evolved a special set of solutions to the general problems that all organisms must face. By the fact of its existence, a species demonstrates that its members are able to carry out adequately a series of general functions. … These general functions offer a framework within which one can integrate one’s view of biology and focus one’s research. Such a view helps one to avoid becoming lost in a morass of unstructured detail—even though the ways in which different species perform these functions may differ widely. A few obvious examples will suffice. Organisms must remain functionally integrated. They must obtain materials from their environments, and process and release energy from these materials. … They must differentiate and grow, and they must reproduce. By focusing one’s questions on one or another of these obligatory and universal capacities, one can ensure that one’s research will not be trivial and that it will have some chance of achieving broad general applicability.

Ecology has not yet explicitly developed the kind of cohesive, simplifying generalizations exemplified by, say, the laws of physics. Nevertheless there are a number of generalizations that are already evident in what we now know about the ecosphere and that can be organized into a kind of informal set of laws of ecology.

Education is the process of driving a set of prejudices down your throat.

Ethnologists regard man as the primitive element of tribes, races, and peoples. The anthropologist looks at him as a member of the fauna of the globe, belonging to a zoölogical classification, and subject to the same laws as the rest of the animal kingdom. To study him from the last point of view only would be to lose sight of some of his most interesting and practical relations; but to be confined to the ethnologist’s views is to set aside the scientific rule which requires us to proceed from the simple to the compound, from the known to the unknown, from the material and organic fact to the functional phenomenon.

Euclid alone has looked on Beauty bare.
Let all who prate of Beauty hold their peace,
And lay them prone upon the earth and cease
To ponder on themselves, the while they stare
At nothing, intricately drawn nowhere
In shapes of shifting lineage; let geese
Gabble and hiss, but heroes seek release
From dusty bondage into luminous air.
O blinding hour, O holy, terrible day,
When first the shaft into his vision shone
Of light anatomized! Euclid alone
Has looked on Beauty bare. Fortunate they
Who, though once only and then but far away,
Have heard her massive sandal set on stone.

Even if there is only one possible unified theory, it is just a set of rules and equations. What is it that breathes fire into the equations and makes a universe for them to describe? The usual approach of science of constructing a mathematical model cannot answer the questions of why there should be a universe for the model to describe. Why does the universe go to all the bother of existing?

Even though the realms of religion and science in themselves are clearly marked off from each other, nevertheless there exist between the two strong reciprocal relationships and dependencies. Though religion may be that which determines the goal, it has, nevertheless, learned from science, in the broadest sense, what means will contribute to the attainment of the goals it has set up. But science can only be created by those who are thoroughly imbued with the aspiration toward truth and understanding. This source of feeling, however, springs from the sphere of religion. To this there also belongs the faith in the possibility that the regulations valid for the world of existence are rational, that is, comprehensible to reason. I cannot conceive of a genuine scientist without that profound faith. The situation may be expressed by an image: science without religion is lame, religion without science is blind.

Every complete set of chromosomes contains the full code; so there are, as a rule, two copies of the latter in the fertilized egg cell, which forms the earliest stage of the future individual. In calling the structure of the chromosome fibres a code-script we mean that the all-penetrating mind, once conceived by Laplace, to which every causal connection lay immediately open, could tell from their structure whether the egg would develop, under suitable conditions, into a black cock or into a speckled hen, into a fly or a maize plant, a rhododendron, a beetle, a mouse or a woman. To which we may add, that the appearances of the egg cells are very often remarkably similar; and even when they are not, as in the case of the comparatively gigantic eggs of birds and reptiles, the difference is not so much in the relevant structures as in the nutritive material which in these cases is added for obvious reasons.
But the term code-script is, of course, too narrow. The chromosome structures are at the same time instrumental in bringing about the development they foreshadow. They are law-code and executive power?or, to use another simile, they are architect's plan and builder’s craft-in one.

Every investigator must before all things look upon himself as one who is summoned to serve on a jury. He has only to consider how far the statement of the case is complete and clearly set forth by the evidence. Then he draws his conclusion and gives his vote, whether it be that his opinion coincides with that of the foreman or not.

Every time a significant discovery is being made one sets in motion a tremendous activity in laboratories and industrial enterprises throughout the world. It is like the ant who suddenly finds food and walks back to the anthill while sending out material called food attracting substance. The other ants follow the path immediately in order to benefit from the finding and continue to do so as long as the supply is rich.

Fine, fine; don't do anything to patch it up. The way things are going, gangrene will set in. Then we can amputate and clean up the problem once and for all.

First, as concerns the success of teaching mathematics. No instruction in the high schools is as difficult as that of mathematics, since the large majority of students are at first decidedly disinclined to be harnessed into the rigid framework of logical conclusions. The interest of young people is won much more easily, if sense-objects are made the starting point and the transition to abstract formulation is brought about gradually. For this reason it is psychologically quite correct to follow this course.
Not less to be recommended is this course if we inquire into the essential purpose of mathematical instruction. Formerly it was too exclusively held that this purpose is to sharpen the understanding. Surely another important end is to implant in the student the conviction that correct thinking based on true premises secures mastery over the outer world. To accomplish this the outer world must receive its share of attention from the very beginning.
Doubtless this is true but there is a danger which needs pointing out. It is as in the case of language teaching where the modern tendency is to secure in addition to grammar also an understanding of the authors. The danger lies in grammar being completely set aside leaving the subject without its indispensable solid basis. Just so in Teaching of Mathematics it is possible to accumulate interesting applications to such an extent as to stunt the essential logical development. This should in no wise be permitted, for thus the kernel of the whole matter is lost. Therefore: We do want throughout a quickening of mathematical instruction by the introduction of applications, but we do not want that the pendulum, which in former decades may have inclined too much toward the abstract side, should now swing to the other extreme; we would rather pursue the proper middle course.

For myself, I found that I was fitted for nothing so well as for the study of Truth; as having a mind nimble and versatile enough to catch the resemblances of things (which is the chief point) , and at the same time steady enough to fix and distinguish their subtler differences; as being gifted by nature with desire to seek, patience to doubt, fondness to meditate, slowness to assert, readiness to reconsider, carefulness to dispose and set in order; and as being a man that neither affects what is new nor admires what is old, and that hates every kind of imposture. So I thought my nature had a kind of familiarity and relationship with Truth.

For the holy Bible and the phenomena of nature proceed alike from the divine Word, the former as the dictate of the Holy Ghost and the latter as the observant executrix of God's commands. It is necessary for the Bible, in order to be accommodated to the understanding of every man, to speak many things which appear to differ from the absolute truth so far as the bare meaning of the words is concerned. But Nature, on the other hand, is inexorable and immutable; she never transgresses the laws imposed upon her, or cares a whit whether her abstruse reasons and methods of operation are understandable to men. For that reason it appears that nothing physical which sense-experience sets before our eyes, or which necessary demonstrations prove to us, ought to be called in question (much less condemned) upon the testimony of biblical passages which may have some different meaning beneath their words.

For these two years I have been gravitating towards your doctrines, and since the publication of your primula paper with accelerated velocity. By about this time next year I expect to have shot past you, and to find you pitching into me for being more Darwinian than yourself. However, you have set me going, and must just take the consequences, for I warn you I will stop at no point so long as clear reasoning will take me further.

For, in mathematics or symbolic logic, reason can crank out the answer from the symboled equations—even a calculating machine can often do so—but it cannot alone set up the equations. Imagination resides in the words which define and connect the symbols—subtract them from the most aridly rigorous mathematical treatise and all meaning vanishes. Was it Eddington who said that we once thought if we understood 1 we understood 2, for 1 and 1 are 2, but we have since found we must learn a good deal more about “and”?

FORTRAN —’the infantile disorder’—, by now nearly 20 years old, is hopelessly inadequate for whatever computer application you have in mind today: it is now too clumsy, too risky, and too expensive to use. PL/I —’the fatal disease’— belongs more to the problem set than to the solution set. It is practically impossible to teach good programming to students that have had a prior exposure to BASIC: as potential programmers they are mentally mutilated beyond hope of regeneration. The use of COBOL cripples the mind; its teaching should, therefore, be regarded as a criminal offence. APL is a mistake, carried through to perfection. It is the language of the future for the programming techniques of the past: it creates a new generation of coding bums.

Fractal is a word invented by Mandelbrot to bring together under one heading a large class of objects that have [played] … an historical role … in the development of pure mathematics. A great revolution of ideas separates the classical mathematics of the 19th century from the modern mathematics of the 20th. Classical mathematics had its roots in the regular geometric structures of Euclid and the continuously evolving dynamics of Newton. Modern mathematics began with Cantor’s set theory and Peano’s space-filling curve. Historically, the revolution was forced by the discovery of mathematical structures that did not fit the patterns of Euclid and Newton. These new structures were regarded … as “pathological,” .… as a “gallery of monsters,” akin to the cubist paintings and atonal music that were upsetting established standards of taste in the arts at about the same time. The mathematicians who created the monsters regarded them as important in showing that the world of pure mathematics contains a richness of possibilities going far beyond the simple structures that they saw in Nature. Twentieth-century mathematics flowered in the belief that it had transcended completely the limitations imposed by its natural origins.
Now, as Mandelbrot points out, … Nature has played a joke on the mathematicians. The 19th-century mathematicians may not have been lacking in imagination, but Nature was not. The same pathological structures that the mathematicians invented to break loose from 19th-century naturalism turn out to be inherent in familiar objects all around us.

Fractals are patterns which occur on many levels. This concept can be applied to any musical parameter. I make melodic fractals, where the pitches of a theme I dream up are used to determine a melodic shape on several levels, in space and time. I make rhythmic fractals, where a set of durations associated with a motive get stretched and compressed and maybe layered on top of each other. I make loudness fractals, where the characteristic loudness of a sound, its envelope shape, is found on several time scales. I even make fractals with the form of a piece, its instrumentation, density, range, and so on. Here I’ve separated the parameters of music, but in a real piece, all of these things are combined, so you might call it a fractal of fractals.

Gaia is a thin spherical shell of matter that surrounds the incandescent interior; it begins where the crustal rocks meet the magma of the Earth’s hot interior, about 100 miles below the surface, and proceeds another 100 miles outwards through the ocean and air to the even hotter thermosphere at the edge of space. It includes the biosphere and is a dynamic physiological system that has kept our planet fit for life for over three billion years. I call Gaia a physiological system because it appears to have the unconscious goal of regulating the climate and the chemistry at a comfortable state for life. Its goals are not set points but adjustable for whatever is the current environment and adaptable to whatever forms of life it carries.

Geometry enlightens the intellect and sets one’s mind right. All of its proofs are very clear and orderly. It is hardly possible for errors to enter into geometrical reasoning, because it is well arranged and orderly. Thus, the mind that constantly applies itself to geometry is not likely to fall into error. In this convenient way, the person who knows geometry acquires intelligence.

God has no intention of setting a limit to the efforts of man to conquer space.

God is love… . We wouldn’t recognize that love. It might even look like hate. It would be enough to scare us—God’s love. It set fire to a bush in the desert, didn’t it, and smashed open graves and set the dead walking in the dark.

Gödel proved that the world of pure mathematics is inexhaustible; no finite set of axioms and rules of inference can ever encompass the whole of mathematics; given any finite set of axioms, we can find meaningful mathematical questions which the axioms leave unanswered. I hope that an analogous Situation exists in the physical world. If my view of the future is correct, it means that the world of physics and astronomy is also inexhaustible; no matter how far we go into the future, there will always be new things happening, new information coming in, new worlds to explore, a constantly expanding domain of life, consciousness, and memory.

going to have an industrial society you must have places that will look terrible. Other places you set aside—to say, ‘This is the way it was.’

Gold is found in our own part of the world; not to mention the gold extracted from the earth in India by the ants, and in Scythia by the Griffins. Among us it is procured in three different ways; the first of which is in the shape of dust, found in running streams. … A second mode of obtaining gold is by sinking shafts or seeking among the debris of mountains …. The third method of obtaining gold surpasses the labors of the giants even: by the aid of galleries driven to a long distance, mountains are excavated by the light of torches, the duration of which forms the set times for work, the workmen never seeing the light of day for many months together.

Groves hated the weather, and the weathermen; they represented chaos and the messengers of chaos. Weather violated boundaries, ignored walls and gates, failed to adhere to deadlines, disobeyed orders. Weather caused delays. The weather forecasters had opposed the [atomic bomb] test date for months—it was set within a window of unfavorable conditions: thunderstorms, rain, high winds, inversion layers. Groves had overridden them. … Groves saw it as a matter of insubordination when the weather forecasters refused to forecast good weather for the test.

He who studies it [Nature] has continually the exquisite pleasure of discerning or half discerning and divining laws; regularities glimmer through an appearance of confusion, analogies between phenomena of a different order suggest themselves and set the imagination in motion; the mind is haunted with the sense of a vast unity not yet discoverable or nameable. There is food for contemplation which never runs short; you are gazing at an object which is always growing clearer, and yet always, in the very act of growing clearer, presenting new mysteries.

Hence when a person is in great pain, the cause of which he cannot remove, he sets his teeth firmly together, or bites some substance between them with great vehemence, as another mode of violent exertion to produce a temporary relief. Thus we have the proverb where no help can be has in pain, 'to grin and abide;' and the tortures of hell are said to be attended with 'gnashing of teeth.'Describing a suggestion of the origin of the grin in the present form of a proverb, 'to grin and bear it.'

Hence, even in the domain of natural science the aid of the experimental method becomes indispensable whenever the problem set is the analysis of transient and impermanent phenomena, and not merely the observation of persistent and relatively constant objects.

Here I shall present, without using Analysis [mathematics], the principles and general results of the Théorie, applying them to the most important questions of life, which are indeed, for the most part, only problems in probability. One may even say, strictly speaking, that almost all our knowledge is only probable; and in the small number of things that we are able to know with certainty, in the mathematical sciences themselves, the principal means of arriving at the truth—induction and analogy—are based on probabilities, so that the whole system of human knowledge is tied up with the theory set out in this essay.

Here men from the planet Earth first set foot upon the Moon July 1969, A.D. We came in peace for all mankind.

How can you shorten the subject? That stern struggle with the multiplication table, for many people not yet ended in victory, how can you make it less? Square root, as obdurate as a hardwood stump in a pasture nothing but years of effort can extract it. You can’t hurry the process. Or pass from arithmetic to algebra; you can’t shoulder your way past quadratic equations or ripple through the binomial theorem. Instead, the other way; your feet are impeded in the tangled growth, your pace slackens, you sink and fall somewhere near the binomial theorem with the calculus in sight on the horizon. So died, for each of us, still bravely fighting, our mathematical training; except for a set of people called “mathematicians”—born so, like crooks.