That the general characters of the big group to which the embryo belongs appear in development earlier than the special characters. In agreement with this is the fact that the vesicular form is the most general form of all; for what is common in a greater degree to all animals than the opposition of an internal and an external surface?
The less general structural relations are formed after the more general, and so on until the most special appear.
The embryo of any given form, instead of passing through the state of other definite forms, on the contrary separates itself from them.
Fundamentally the embryo of a higher animal form never resembles the adult of another animal form, but only its embryo.

By the act of generation nothing more is done than to ferment the sperm of ye female by the sperm of ye male that it may thereby become fit nourishment for ye Embryo: ffor ye nourishment of all animals is prepared by ferment & the ferment is taken from animals of the same kind, & makes the nourishment subtile & spiritual. In adult animals the nourishm^t is fermented by the choler and pancreatic juice both w^ch come from the blood. The Embryo not being able to ferment its own nourishment w^ch comes from the mothers blood has it fermented by the sperm w^ch comes from ye fathers blood, & by this nourishment it swells, drops off from ye Ovarium & begins to grow with a life distinct from that of ye mother.

Chemistry is yet, indeed, a mere embryon. Its principles are contested; experiments seem contradictory; their subjects are so minute as to escape our senses; and their result too fallacious to satisfy the mind. It is probably an age too soon to propose the establishment of a system.

Dear Mr. Bell: … Sir Wm. Thomson … speaks with much enthusiasm of your achievement. What yesterday he would have declared impossible he has today seen realized, and he declares it the most wonderful thing he has seen in America. You speak of it as an embryo invention, but to him it seems already complete, and he declares that, before long, friends will whisper their secrets over the electric wire. Your undulating current he declares a great and happy conception.

During the half-century that has elapsed since the enunciation of the cell-theory by Schleiden and Schwann, in 1838-39, it has became ever more clearly apparent that the key to all ultimate biological problems must, in the last analysis, be sought in the cell. It was the cell-theory that first brought the structure of plants and animals under one point of view by revealing their common plan of organization. It was through the cell-theory that Kolliker and Remak opened the way to an understanding of the nature of embryological development, and the law of genetic continuity lying at the basis of inheritance. It was the cell-­theory again which, in the hands of Virchaw and Max Schultze, inaugurated a new era in the history of physiology and pathology, by showing that all the various functions of the body, in health and in disease, are but the outward expression of cell­-activities. And at a still later day it was through the cell-theory that Hertwig, Fol, Van Beneden, and Strasburger solved the long-standing riddle of the fertilization of the egg, and the mechanism of hereditary transmission. No other biological generalization, save only the theory of organic evolution, has brought so many apparently diverse phenomena under a common point of view or has accomplished more far the unification of knowledge. The cell-theory must therefore be placed beside the evolution-theory as one of the foundation stones of modern biology.

I strongly oppose cloning, as do most Americans. We recoil at the idea of growing human beings for spare body parts or creating life for our convenience. And while we must devote enormous energy to conquering disease, it is equally important that we pay attention to the moral concerns raised by the new frontier of human embryo stem cell research. Even the most noble ends do not justify any means.

If the man of science chose to follow the example of historians and pulpit-orators, and to obscure strange and peculiar phenomena by employing a hollow pomp of big and sounding words, this would be his opportunity; for we have approached one of the greatest mysteries which surround the problem of animated nature and distinguish it above all other problems of science. To discover the relations of man and woman to the egg-cell would be almost equivalent of the egg-cell in the body of the mother, the transfer to it by means of the seed, of the physical and mental characteristics of the father, affect all the questions which the human mind has ever raised in regard to existence.

Immediately after the separation of the formative materials into the two layers of the germ-primule, there appears in the ectoderm a groove, open above, at the bottom of which is a streak of darker tissue.

In recent weeks we learned that scientists have created human embryos in test tubes solely to experiment on them. This is deeply troubling, and a warning sign that should prompt all of us to think through these issues very carefully.

In systemic searches for embryonic lethal mutants of Drosophila melanogaster we have identified 15 loci which when mutated alter the segmental patterns of the larva. These loci probably represent the majority of such genes in Drosophila. The phenotypes of the mutant embryos indicate that the process of segmentation involves at least three levels of spatial organization: the entire egg as developmental unit, a repeat unit with the length of two segments, and the individual segment.
[Co-author with American physiologist Eric Wieshaus (1947-)]

In the real changes which animals undergo during their embryonic growth, in those external transformations as well as in those structural modifications within the body, we have a natural scale to measure the degree or the gradation of those full grown animals which corresponds in their external form and in their structure, to those various degrees in the metamorphoses of animals, as illustrated by embryonic changes, a real foundation for zoological classification.

Is man a peculiar organism? Does he originate in a wholly different way from a dog, bird, frog, or fish? and does he thereby justify those who assert that he has no place in nature, and no real relationship with the lower world of animal life? Or does he develop from a similar embryo, and undergo the same slow and gradual progressive modifications? The answer is not for an instant doubtful, and has not been doubtful for the last thirty years. The mode of man’s origin and the earlier stages of his development are undoubtedly identical with those of the animals standing directly below him in the scale; without the slightest doubt, he stands in this respect nearer the ape than the ape does to the dog. (1863)

It is therefore proper to acknowledge that the first filaments of the chick preexist in the egg and have a deeper origin, exactly as [the embryo] in the eggs of plants.

Let us only imagine that birds had studied their own development and that it was they in turn who investigated the structure of the adult mammal and of man. Wouldn’t their physiological textbooks teach the following? “Those four and two-legged animals bear many resemblances to embryos, for their cranial bones are separated, and they have no beak, just as we do in the first live or six days of incubation; their extremities are all very much alike, as ours are for about the same period; there is not a single true feather on their body, rather only thin feather-shafts, so that we, as fledglings in the nest, are more advanced than they shall ever be … And these mammals that cannot find their own food for such a long time after their birth, that can never rise freely from the earth, want to consider themselves more highly organized than we?”

No one has ever done this before, … What we are trying to do here is to create a stem cell line without injuring an embryo. Our cells can go on to become a healthy, kicking baby.

Now that we locate them [genes] in the chromosomes are we justified in regarding them as material units; as chemical bodies of a higher order than molecules? Frankly, these are questions with which the working geneticist has not much concern himself, except now and then to speculate as to the nature of the postulated elements. There is no consensus of opinion amongst geneticists as to what the genes are—whether they are real or purely fictitious—because at the level at which the genetic experiments lie, it does not make the slightest difference whether the gene is a hypothetical unit, or whether the gene is a material particle. In either case the unit is associated with a specific chromosome, and can be localized there by purely genetic analysis. Hence, if the gene is a material unit, it is a piece of chromosome; if it is a fictitious unit, it must be referred to a definite location in a chromosome—the same place as on the other hypothesis. Therefore, it makes no difference in the actual work in genetics which point of view is taken. Between the characters that are used by the geneticist and the genes that his theory postulates lies the whole field of embryonic development.

The development of the Vertebrate proceeds from an axis upward, in two layers, which coalesce at the edges, and also downward, in two layers, which likewise coalesce at the edges. Thus two main tubes are formed, one above the other. During the formation of these, the embryo separates into strata, so that the two main tubes are composed of subordinate tubes which enclose each other as fundamental organs, and are capable of developing into all the organs.

The distinguishing of the strata, or layers, in the embryonic membrane was a turning-point in the study of the history of evolution, and placed later researches in their proper light. A division of the (disc-shaped) embryo into an animal and a plastic part first takes place. In the lower part (the plastic or vegetative layer) are a serous and a vascular layer, each of peculiar organization. In the upper part also (the animal or serous germ-layer) two layers are clearly distinguishable, a flesh-layer and a skin-layer. (1828)

The embryos of mammals, of birds, lizards, and snakes are, in their earliest states, exceedingly like one another, both as a whole and in the mode of development of their parts, indeed we can often distinguish such embryos only by their size. I have two little embryos in spirit [alcohol] to which I have omitted to attach the names. I am now quite unable to say to what class they belong.

The extracellular genesis of cells in animals seemed to me, ever since the publication of the cell theory [of Schwann], just as unlikely as the spontaneous generation of organisms. These doubts produced my observations on the multiplication of blood cells by division in bird and mammalian embryos and on the division of muscle bundles in frog larvae. Since then I have continued these observations in frog larvae, where it is possible to follow the history of tissues back to segmentation.

The seed of a tree has the nature of a branch or twig or bud. While it grows upon the tree it is a part of the tree: but if separated and set in the earth to be better nourished, the embryo or young tree contained in it takes root and grows into a new tree.

We may therefore say in the future, strictly within the limits of observation, that in certain respects the fossil species of a class traverse in their historical succession metamorphoses similar to those which the embryos undergo in themselves. … The development of a class in the history of the earth offers, in many respects, the greatest analogy with the development of an individual at different periods of his life. The demonstration of this truth is one of the most beautiful results of modern paleontology.

We shall therefore take an appropriately correct view of the origin of our life, if we consider our own embryos to have sprung immediately from those embryos whence our parents were developed, and these from the embryos of their parents, and so on for ever. We should in this way look on the nature of mankind, and perhaps on that of the whole animated creation, as one Continuous System, ever pushing out new branches in all directions, that variously interlace, and that bud into separate lives at every point of interlacement.