...Outer space, once a region of spirited international competition, is also a region of international cooperation. I realized this as early as 1959, when I attended an international conference on cosmic radiation in Moscow. At this conference, there were many differing views and differing methods of attack, but the problems were common ones to all of us and a unity of basic purpose was everywhere evident. Many of the papers presented there depended in an essential way upon others which had appeared originally in as many as three or four different languages. Surely science is one of the universal human activities.

“Facts, facts, facts,” cries the scientist if he wants to emphasize the necessity of a firm foundation for science. What is a fact? A fact is a thought that is true. But the scientist will surely not recognize something which depends on men's varying states of mind to be the firm foundation of science.

“Would you tell me please, which way I ought to go from here?”
“That depends a good deal on where you want to get to,” said the Cat.
“I don’t much care where … ,” said Alice.
“Then it doesn’t matter which way you go,” said the Cat.
“So long as I get somewhere,” Alice added as an explanation. “Oh, you’re sure to do that,” said the Cat, “if only you walk long enough.”

[Alice asks the Cheshire Cat] Would you tell me, please, which way I ought to walk from here?
“That depends a good deal on where you want to get to,” said the Cat.
“I don’t much care where———” said Alice.
“Then it doesn’t matter which way you walk,” said the Cat.

[In geology,] As in history, the material in hand remains silent if no questions are asked. The nature of these questions depends on the “school” to which the geologist belongs and on the objectivity of his investigations. Hans Cloos called this way of interrogation “the dialogue with the earth,” “das Gesprach mit der Erde.”

[It] is not the nature of things for any one man to make a sudden, violent discovery; science goes step by step and every man depends on the work of his predecessors. When you hear of a sudden unexpected discovery—a bolt from the blue—you can always be sure that it has grown up by the influence of one man or another, and it is the mutual influence which makes the enormous possibility of scientific advance. Scientists are not dependent on the ideas of a single man, but on the combined wisdom of thousands of men, all thinking of the same problem and each doing his little bit to add to the great structure of knowledge which is gradually being erected.

[Microscopic] evidence cannot be presented ad populum. What is seen with the microscope depends not only upon the instrument and the rock-section, but also upon the brain behind the eye of the observer. Each of us looks at a section with the accumulated experience of his past study. Hence the veteran cannot make the novice see with his eyes; so that what carries conviction to the one may make no appeal to the other. This fact does not always seem to be sufficiently recognized by geologists at large.

[Mitscherlich Law of Isomerism] An equal number of atoms, combined in the same way produce the same crystal forms, and the same crystal form does not depend on the nature of the atoms, but only on their number and mode of combination.

[The object of education is] to train the mind to ascertain the sequence of a particular conclusion from certain premises, to detect a fallacy, to correct undue generalisation, to prevent the growth of mistakes in reasoning. Everything in these must depend on the spirit and the manner in which the instruction itself is conveyed and honoured. If you teach scientific knowledge without honouring scientific knowledge as it is applied, you do more harm than good. I do think that the study of natural science is so glorious a school for the mind, that with the laws impressed on all these things by the Creator, and the wonderful unity and stability of matter, and the forces of matter, there cannot be a better school for the education of the mind.

Dogbert: So, Since Columbus is dead, you have no evidence that the earth is round.
Dilbert: Look. You can Ask Senator John Glenn. He orbited the earth when he was an astronaut.
Dogbert: So, your theory depends on the honesty of politicians.
Dilbert: Yes... no, wait...

Question: If you were to pour a pound of molten lead and a pound of molten iron, each at the temperature of its melting point, upon two blocks of ice, which would melt the most ice, and why?
Answer: This question relates to diathermancy. Iron is said to be a diathermanous body (from dia, through, and thermo, I heat), meaning that it gets heated through and through, and accordingly contains a large quantity of real heat. Lead is said to be an athermanous body (from a, privative, and thermo, I heat), meaning that it gets heated secretly or in a latent manner. Hence the answer to this question depends on which will get the best of it, the real heat of the iron or the latent heat of the lead. Probably the iron will smite furthest into the ice, as molten iron is white and glowing, while melted lead is dull.

Question: Why do the inhabitants of cold climates eat fat? How would you find experimentally the relative quantities of heat given off when equal weights of sulphur, phosphorus, and carbon are thoroughly burned?
Answer: An inhabitant of cold climates (called Frigid Zoans) eats fat principally because he can't get no lean, also because he wants to rise is temperature. But if equal weights of sulphur phosphorus and carbon are burned in his neighbourhood he will give off eating quite so much. The relative quantities of eat given off will depend upon how much sulphur etc. is burnt and how near it is burned to him. If I knew these facts it would be an easy sum to find the answer.

A cell has a history; its structure is inherited, it grows, divides, and, as in the embryo of higher animals, the products of division differentiate on complex lines. Living cells, moreover, transmit all that is involved in their complex heredity. I am far from maintaining that these fundamental properties may not depend upon organisation at levels above any chemical level; to understand them may even call for different methods of thought; I do not pretend to know. But if there be a hierarchy of levels we must recognise each one, and the physical and chemical level which, I would again say, may be the level of self-maintenance, must always have a place in any ultimate complete description.

A hundred times every day I remind myself that my inner and outer life depends on the labors of other men, living and dead, and that I must exert myself in order to give in the measure as I have received and am still receiving.

A little science is something that they must have. I should like my nephews to know what air is, and water; why we breathe, and why wood burns; the nutritive elements essential to plant life, and the constituents of the soil. And it is no vague and imperfect knowledge from hearsay I would have them gain of these fundamental truths, on which depend agriculture and the industrial arts and our health itself; I would have them know these things thoroughly from their own observation and experience. Books here are insufficient, and can serve merely as aids to scientific experiment.

A man’s value to the community depends primarily on how far his feelings, thoughts, and actions are directed towards promoting the good of his fellows. We call him good or bad according to how he stands in this matter. It looks at first sight as if our estimate of a man depended entirely on his social qualities.

A nation which depends upon others for its new basic scientific knowledge will be slow in its industrial progress and weak in its competitive position in world trade, regardless of its mechanical skill.

A plain, reasonable working man supposes, in the old way which is also the common-sense way, that if there are people who spend their lives in study, whom he feeds and keeps while they think for him—then no doubt these men are engaged in studying things men need to know; and he expects of science that it will solve for him the questions on which his welfare, and that of all men, depends. He expects science to tell him how he ought to live: how to treat his family, his neighbours and the men of other tribes, how to restrain his passions, what to believe in and what not to believe in, and much else. And what does our science say to him on these matters?
It triumphantly tells him: how many million miles it is from the earth to the sun; at what rate light travels through space; how many million vibrations of ether per second are caused by light, and how many vibrations of air by sound; it tells of the chemical components of the Milky Way, of a new element—helium—of micro-organisms and their excrements, of the points on the hand at which electricity collects, of X rays, and similar things.
“But I don't want any of those things,” says a plain and reasonable man—“I want to know how to live.”

A prolonged war in which a nation takes part is bound to impoverish the breed, since the character of the breed depends on the men who are left.

A strict materialist believes that everything depends on the motion of matter. He knows the form of the laws of motion though he does not know all their consequences when applied to systems of unknown complexity.
Now one thing in which the materialist (fortified with dynamical knowledge) believes is that if every motion great & small were accurately reversed, and the world left to itself again, everything would happen backwards the fresh water would collect out of the sea and run up the rivers and finally fly up to the clouds in drops which would extract heat from the air and evaporate and afterwards in condensing would shoot out rays of light to the sun and so on. Of course all living things would regrede from the grave to the cradle and we should have a memory of the future but not of the past.
The reason why we do not expect anything of this kind to take place at any time is our experience of irreversible processes, all of one kind, and this leads to the doctrine of a beginning & an end instead of cyclical progression for ever.

About the year 1821, I undertook to superintend, for the Government, the construction of an engine for calculating and printing mathematical and astronomical tables. Early in the year 1833, a small portion of the machine was put together, and was found to perform its work with all the precision which had been anticipated. At that period circumstances, which I could not control, caused what I then considered a temporary suspension of its progress; and the Government, on whose decision the continuance or discontinuance of the work depended, have not yet communicated to me their wishes on the question.

According to the poet, “The world’s bread depends on the shooting of a seed.”

All depends on keeping the eye steadily fixed on the facts of nature and so receiving their images simply as they are.

All important unit operations have much in common, and if the underlying principles upon which the rational design and operation of basic types of engineering equipment depend are understood, their successful adaptation to manufacturing processes becomes a matter of good management rather than of good fortune.

All life depends on organic reactions.
A favorite saying.

All life is linked together in such a way that no part of the chain is unimportant. Frequently, upon the action of some of these minute beings depends the material success or failure of a great commonwealth.

All scientists must focus closely on limited targets. Whether or not one’s findings on a limited subject will have wide applicability depends to some extent on chance, but biologists of superior ability repeatedly focus on questions the answers to which either have wide ramifications or lead to new areas of investigation. One procedure that can be effective is to attempt both reduction and synthesis; that is, direct a question at a phenomenon on one integrative level, identify its mechanism at a simpler level, then extrapolate its consequences to a more complex level of integration.

All that is valuable in human society depends upon the opportunity for development accorded the individual.

All the knowledge we have of nature depends upon facts; for without observations and experiments our natural philosophy would only be a science of terms and an unintelligible jargon.

All the scientist creates in a fact is the language in which he enunciates it. If he predicts a fact, he will employ this language, and for all those who can speak and understand it, his prediction is free from ambiguity. Moreover, this prediction once made, it evidently does not depend upon him whether it is fulfilled or not.

And so I conclude that blood lives and is nourished of itself and in no way depends on any other part of the body as being prior to it or more excellent... So that from this we may perceive the causes not only of life in general... but also of longer or shorter life, of sleeping and waking, of skill, of strength and so forth.

Any opinion as to the form in which the energy of gravitation exists in space is of great importance, and whoever can make his opinion probable will have, made an enormous stride in physical speculation. The apparent universality of gravitation, and the equality of its effects on matter of all kinds are most remarkable facts, hitherto without exception; but they are purely experimental facts, liable to be corrected by a single observed exception. We cannot conceive of matter with negative inertia or mass; but we see no way of accounting for the proportionality of gravitation to mass by any legitimate method of demonstration. If we can see the tails of comets fly off in the direction opposed to the sun with an accelerated velocity, and if we believe these tails to be matter and not optical illusions or mere tracks of vibrating disturbance, then we must admit a force in that direction, and we may establish that it is caused by the sun if it always depends upon his position and distance.

As a general scientific principle, it is undesirable to depend crucially on what is unobservable to explain what is observable, as happens frequently in Big Bang cosmology.

As arithmetic and algebra are sciences of great clearness, certainty, and extent, which are immediately conversant about signs, upon the skilful use whereof they entirely depend, so a little attention to them may possibly help us to judge of the progress of the mind in other sciences, which, though differing in nature, design, and object, may yet agree in the general methods of proof and inquiry.

As he [Clifford] spoke he appeared not to be working out a question, but simply telling what he saw. Without any diagram or symbolic aid he described the geometrical conditions on which the solution depended, and they seemed to stand out visibly in space. There were no longer consequences to be deduced, but real and evident facts which only required to be seen. … So whole and complete was his vision that for the time the only strange thing was that anybody should fail to see it in the same way. When one endeavored to call it up again, and not till then, it became clear that the magic of genius had been at work, and that the common sight had been raised to that higher perception by the power that makes and transforms ideas, the conquering and masterful quality of the human mind which Goethe called in one word das Dämonische.

As we continue to improve our understanding of the basic science on which applications increasingly depend, material benefits of this and other kinds are secured for the future.

Astronomy is a cold, desert science, with all its pompous figures,—depends a little too much on the glass-grinder, too little on the mind. ’Tis of no use to show us more planets and systems. We know already what matter is, and more or less of it does not signify.

Attention makes the genius; all learning, fancy, and science depend on it. Newton traced back his discoveries to its unwearied employment. It builds bridges, opens new worlds, and heals diseases; without it Taste is useless, and the beauties of literature are unobserved; as the rarest flowers bloom in vain, if the eye be not fixed upon the bed.

Besides accustoming the student to demand, complete proof, and to know when he has not obtained it, mathematical studies are of immense benefit to his education by habituating him to precision. It is one of the peculiar excellencies of mathematical discipline, that the mathematician is never satisfied with à peu près. He requires the exact truth. Hardly any of the non-mathematical sciences, except chemistry, has this advantage. One of the commonest modes of loose thought, and sources of error both in opinion and in practice, is to overlook the importance of quantities. Mathematicians and chemists are taught by the whole course of their studies, that the most fundamental difference of quality depends on some very slight difference in proportional quantity; and that from the qualities of the influencing elements, without careful attention to their quantities, false expectation would constantly be formed as to the very nature and essential character of the result produced.

Better to hunt in fields, for health unbought, Than fee the doctor for a nauseous draught, The wise, for cure, on exercise depend; God never made his work for man to mend.

Bistromathics itself is simply a revolutionary new way of understanding the behavior of numbers. Just as Einstein observed that space was not an absolute but depended on the observer's movement in space, and that time was not an absolute, but depended on the observer's movement in time, so it is now realized that numbers are not absolute, but depend on the observer's movement in restaurants.

Break the chains of your prejudices and take up the torch of experience, and you will honour nature in the way she deserves, instead of drawing derogatory conclusions from the ignorance in which she has left you. Simply open your eyes and ignore what you cannot understand, and you will see that a labourer whose mind and knowledge extend no further than the edges of his furrow is no different essentially from the greatest genius, as would have been proved by dissecting the brains of Descartes and Newton; you will be convinced that the imbecile or the idiot are animals in human form, in the same way as the clever ape is a little man in another form; and that, since everything depends absolutely on differences in organisation, a well-constructed animal who has learnt astronomy can predict an eclipse, as he can predict recovery or death when his genius and good eyesight have benefited from some time at the school of Hippocrates and at patients' bedsides.

But shall gravity be therefore called an occult cause, and thrown out of philosophy, because the cause of gravity is occult and not yet discovered? Those who affirm this, should be careful not to fall into an absurdity that may overturn the foundations of all philosophy. For causes usually proceed in a continued chain from those that are more compounded to those that are more simple; when we are arrived at the most simple cause we can go no farther ... These most simple causes will you then call occult and reject them? Then you must reject those that immediately depend on them.

But when it has been shown by the researches of Pasteur that the septic property of the atmosphere depended not on the oxygen, or any gaseous constituent, but on minute organisms suspended in it, which owed their energy to their vitality, it occurred to me that decomposition in the injured part might be avoided without excluding the air, by applying as a dressing some material capable of destroying the life of the floating particles. Upon this principle I have based a practice.

Call Archimedes from his buried tomb
Upon the plain of vanished Syracuse,
And feelingly the sage shall make report
How insecure, how baseless in itself,
Is the philosophy, whose sway depends
On mere material instruments—how weak
Those arts, and high inventions, if unpropped
By virtue.

Chemistry works with an enormous number of substances, but cares only for some few of their properties; it is an extensive science. Physics on the other hand works with rather few substances, such as mercury, water, alcohol, glass, air, but analyses the experimental results very thoroughly; it is an intensive science. Physical chemistry is the child of these two sciences; it has inherited the extensive character from chemistry. Upon this depends its all-embracing feature, which has attracted so great admiration. But on the other hand it has its profound quantitative character from the science of physics.

Clean water is a great example of something that depends on energy. And if you solve the water problem, you solve the food problem.

Consider the very roots of our ability to discern truth. Above all (or perhaps I should say “underneath all”), common sense is what we depend on—that crazily elusive, ubiquitous faculty we all have to some degree or other. … If we apply common sense to itself over and over again, we wind up building a skyscraper. The ground floor of the structure is the ordinary common sense we all have, and the rules for building news floors are implicit in the ground floor itself. However, working it all out is a gigantic task, and the result is a structure that transcends mere common sense.

Culture in its higher forms is a delicate plant which depends on a complicated set of conditions and is wont to flourish only in a few places at any given time.

Does anyone believe that the difference between the Lebesgue and Riemann integrals can have physical significance, and that whether say, an airplane would or would not fly could depend on this difference? If such were claimed, I should not care to fly in that plane.

Don’t forget that the flavors of wine and cheese depend upon the types of infecting microorganisms.

Even the mind depends so much on temperament and the disposition of one’s bodily organs that, if it is possible to find a way to make people generally more wise and more skilful than they have been in the past, I believe that we should look for it in medicine. It is true that medicine as it is currently practiced contains little of much use.

Every breath you draw, every accelerated beat of your heart in the emotional periods of your oratory depend upon highly elaborated physical and chemical reactions and mechanisms which nature has been building up through a million centuries. If one of these mechanisms, which you owe entirely to your animal ancestry, were to be stopped for a single instant, you would fall lifeless on the stage. Not only this, but some of your highest ideals of human fellowship and comradeship were not created in a moment, but represent the work of ages.

Everything that depends on the action of nature is by nature as good as it can be.

Facts are to the mind the same thing as food to the body. On the due digestion of facts depends the strength and wisdom of the one, just as vigor and health depend on the other. The wisest in council, the ablest in debate, and the most agreeable in the commerce of life is that man who has assimilated to his understanding the greatest number of facts.

Finally in a large population, divided and subdivided into partially isolated local races of small size, there is a continually shifting differentiation among the latter (intensified by local differences in selection but occurring under uniform and static conditions) which inevitably brings about an indefinitely continuing, irreversible, adaptive, and much more rapid evolution of the species. Complete isolation in this case, and more slowly in the preceding, originates new species differing for the most part in nonadaptive parallel orthogenetic lines, in accordance with the conditions. It is suggested, in conclusion, that the differing statistical situations to be expected among natural species are adequate to account for the different sorts of evolutionary processes which have been described, and that, in particular, conditions in nature are often such as to bring about the state of poise among opposing tendencies on which an indefinitely continuing evolutionary process depends.

Finally, since I thought that we could have all the same thoughts, while asleep, as we have while we are awake, although none of them is true at that time, I decided to pretend that nothing that ever entered my mind was any more true than the illusions of my dreams. But I noticed, immediately afterwards, that while I thus wished to think that everything was false, it was necessarily the case that I, who was thinking this, was something. When I noticed that this truth “I think, therefore I am” was so firm and certain that all the most extravagant assumptions of the sceptics were unable to shake it, I judged that I could accept it without scruple as the first principle of the philosophy for which I was searching. Then, when I was examining what I was, I realized that I could pretend that I had no body, and that there was no world nor any place in which I was present, but I could not pretend in the same way that I did not exist. On the contrary, from the very fact that I was thinking of doubting the truth of other things, it followed very evidently and very certainly that I existed; whereas if I merely ceased to think, even if all the rest of what I had ever imagined were true, I would have no reason to believe that I existed. I knew from this that I was a substance, the whole essence or nature of which was to think and which, in order to exist, has no need of any place and does not depend on anything material. Thus this self—that is, the soul by which I am what I am—is completely distinct from the body and is even easier to know than it, and even if the body did not exist the soul would still be everything that it is.

For the saving the long progression of the thoughts to remote and first principles in every case, the mind should provide itself several stages; that is to say, intermediate principles, which it might have recourse to in the examining those positions that come in its way. These, though they are not self-evident principles, yet, if they have been made out from them by a wary and unquestionable deduction, may be depended on as certain and infallible truths, and serve as unquestionable truths to prove other points depending upon them, by a nearer and shorter view than remote and general maxims. … And thus mathematicians do, who do not in every new problem run it back to the first axioms through all the whole train of intermediate propositions. Certain theorems that they have settled to themselves upon sure demonstration, serve to resolve to them multitudes of propositions which depend on them, and are as firmly made out from thence as if the mind went afresh over every link of the whole chain that tie them to first self-evident principles.

For, every time a certain portion is destroyed, be it of the brain or of the spinal cord, a function is compelled to cease suddenly, and before the time known beforehand when it would stop naturally, it is certain that this function depends upon the area destroyed. It is in this way that I have recognized that the prime motive power of respiration has its seat in that part of the medulla oblongata that gives rise to the nerves of the eighth pair [vagi]; and it is by this method that up to a certain point it will be possible to discover the use of certain parts of the brain.

Four elements, hydrogen, carbon, oxygen and nitrogen, also provide an example of the astonishing togetherness of our universe. They make up the “organic” molecules that constitute living organisms on a planet, and the nuclei of these same elements interact to generate the light of its star. Then the organisms on the planet come to depend wholly on that starlight, as they must if life is to persist. So it is that all life on the Earth runs on sunlight. [Referring to photosynthesis]

Further, it will not be amiss to distinguish the three kinds and, as it were, grades of ambition in mankind. The first is of those who desire to extend their own power in their native country, a vulgar and degenerate kind. The second is of those who labor to extend the power and dominion of their country among men. This certainly has more dignity, though not less covetousness. But if a man endeavor to establish and extend the power and dominion of the human race itself over the universe, his ambition (if ambition it can be called) is without doubt both a more wholesome and a more noble thing than the other two. Now the empire of man over things depends wholly on the arts and sciences. For we cannot command nature except by obeying her.

Geology depends on impressions made by floods, earthquakes, volcanoes. The mountains tell the story of their oppressions and rebellions. The outstanding data of this science of Mother Earth are those furnished by the most violent impressions that mark an epoch in evolution

He [Lord Bacon] appears to have been utterly ignorant of the discoveries which had just been made by Kepler’s calculations … he does not say a word about Napier’s Logarithms, which had been published only nine years before and reprinted more than once in the interval. He complained that no considerable advance had been made in Geometry beyond Euclid, without taking any notice of what had been done by Archimedes and Apollonius. He saw the importance of determining accurately the specific gravities of different substances, and himself attempted to form a table of them by a rude process of his own, without knowing of the more scientific though still imperfect methods previously employed by Archimedes, Ghetaldus and Porta. He speaks of the εὕρηκα of Archimedes in a manner which implies that he did not clearly appreciate either the problem to be solved or the principles upon which the solution depended. In reviewing the progress of Mechanics, he makes no mention either of Archimedes, or Stevinus, Galileo, Guldinus, or Ghetaldus. He makes no allusion to the theory of Equilibrium. He observes that a ball of one pound weight will fall nearly as fast through the air as a ball of two, without alluding to the theory of acceleration of falling bodies, which had been made known by Galileo more than thirty years before. He proposed an inquiry with regard to the lever,—namely, whether in a balance with arms of different length but equal weight the distance from the fulcrum has any effect upon the inclination—though the theory of the lever was as well understood in his own time as it is now. … He speaks of the poles of the earth as fixed, in a manner which seems to imply that he was not acquainted with the precession of the equinoxes; and in another place, of the north pole being above and the south pole below, as a reason why in our hemisphere the north winds predominate over the south.

Heaven forming each on other to depend,
A master, or a servant, or a friend,
Bids each on other for assistance call,
Till one man’s weakness grows the strength of all.

Here I am at the limit which God and nature has assigned to my individuality. I am compelled to depend upon word, language and image in the most precise sense, and am wholly unable to operate in any manner whatever with symbols and numbers which are easily intelligible to the most highly gifted minds.

Historical chronology, human or geological, depends... upon comparable impersonal principles. If one scribes with a stylus on a plate of wet clay two marks, the second crossing the first, another person on examining these marks can tell unambiguously which was made first and which second, because the latter event irreversibly disturbs its predecessor. In virtue of the fact that most of the rocks of the earth contain imprints of a succession of such irreversible events, an unambiguous working out of the chronological sequence of these events becomes possible.

History shows that the human animal has always learned but progress used to be very slow. This was because learning often depended on the chance coming together of a potentially informative event on the one hand and a perceptive observer on the other. Scientific method accelerated that process.

Human beings are sea creatures, dependent on the oceans just as much as whales, herring or coral reefs.

I am particularly concerned to determine the probability of causes and results, as exhibited in events that occur in large numbers, and to investigate the laws according to which that probability approaches a limit in proportion to the repetition of events. That investigation deserves the attention of mathematicians because of the analysis required. It is primarily there that the approximation of formulas that are functions of large numbers has its most important applications. The investigation will benefit observers in identifying the mean to be chosen among the results of their observations and the probability of the errors still to be apprehended. Lastly, the investigation is one that deserves the attention of philosophers in showing how in the final analysis there is a regularity underlying the very things that seem to us to pertain entirely to chance, and in unveiling the hidden but constant causes on which that regularity depends. It is on the regularity of the main outcomes of events taken in large numbers that various institutions depend, such as annuities, tontines, and insurance policies. Questions about those subjects, as well as about inoculation with vaccine and decisions of electoral assemblies, present no further difficulty in the light of my theory. I limit myself here to resolving the most general of them, but the importance of these concerns in civil life, the moral considerations that complicate them, and the voluminous data that they presuppose require a separate work.

I am quite aware that we have just now lightheartedly expelled in imagination many excellent men who are largely, perhaps chiefly, responsible for the buildings of the temple of science; and in many cases our angel would find it a pretty ticklish job to decide. But of one thing I feel sure: if the types we have just expelled were the only types there were, the temple would never have come to be, any more than a forest can grow which consists of nothing but creepers. For these people any sphere of human activity will do, if it comes to a point; whether they become engineers, officers, tradesmen, or scientists depends on circumstances.

I believe that the useful methods of mathematics are easily to be learned by quite young persons, just as languages are easily learned in youth. What a wondrous philosophy and history underlie the use of almost every word in every language—yet the child learns to use the word unconsciously. No doubt when such a word was first invented it was studied over and lectured upon, just as one might lecture now upon the idea of a rate, or the use of Cartesian co-ordinates, and we may depend upon it that children of the future will use the idea of the calculus, and use squared paper as readily as they now cipher. … When Egyptian and Chaldean philosophers spent years in difficult calculations, which would now be thought easy by young children, doubtless they had the same notions of the depth of their knowledge that Sir William Thomson might now have of his. How is it, then, that Thomson gained his immense knowledge in the time taken by a Chaldean philosopher to acquire a simple knowledge of arithmetic? The reason is plain. Thomson, when a child, was taught in a few years more than all that was known three thousand years ago of the properties of numbers. When it is found essential to a boy’s future that machinery should be given to his brain, it is given to him; he is taught to use it, and his bright memory makes the use of it a second nature to him; but it is not till after-life that he makes a close investigation of what there actually is in his brain which has enabled him to do so much. It is taken because the child has much faith. In after years he will accept nothing without careful consideration. The machinery given to the brain of children is getting more and more complicated as time goes on; but there is really no reason why it should not be taken in as early, and used as readily, as were the axioms of childish education in ancient Chaldea.

I cannot separate land and sea: to me they interfinger like a pattern in a moss agate, positive and negative shapes irrevocably interlocked. My knowledge of this peninsula depends on that understanding: of underwater canyons that are continuations of the land, of the shell fossils far inland that measure continuations of the sea in eons past.

I consider that a man’s brain originally is like a little empty attic, and you have to stock it with such furniture as you choose. A fool takes in all the lumber of every sort that he comes across, so that the knowledge which might be useful to him gets crowded out, or at best is jumbled up with a lot of other things so that he has a difficulty in laying his hands upon it. Now the skilful workman is very careful indeed as to what he takes into his brain-attic. He will have nothing but the tools which may help him in doing his work, but of these he has a large assortment, and all in the most perfect order. It is a mistake to think that that little room has elastic walls and can distend to any extent. Depend upon it there comes a time when for every addition of knowledge you forget something that you knew before. It is of the highest importance, therefore, not to have useless facts elbowing out the useful ones.

I despise people who depend on these things [heroin and cocaine]. If you really want a mind-altering experience, look at a tree.

I do not intend to go deeply into the question how far mathematical studies, as the representatives of conscious logical reasoning, should take a more important place in school education. But it is, in reality, one of the questions of the day. In proportion as the range of science extends, its system and organization must be improved, and it must inevitably come about that individual students will find themselves compelled to go through a stricter course of training than grammar is in a position to supply. What strikes me in my own experience with students who pass from our classical schools to scientific and medical studies, is first, a certain laxity in the application of strictly universal laws. The grammatical rules, in which they have been exercised, are for the most part followed by long lists of exceptions; accordingly they are not in the habit of relying implicitly on the certainty of a legitimate deduction from a strictly universal law. Secondly, I find them for the most part too much inclined to trust to authority, even in cases where they might form an independent judgment. In fact, in philological studies, inasmuch as it is seldom possible to take in the whole of the premises at a glance, and inasmuch as the decision of disputed questions often depends on an aesthetic feeling for beauty of expression, or for the genius of the language, attainable only by long training, it must often happen that the student is referred to authorities even by the best teachers. Both faults are traceable to certain indolence and vagueness of thought, the sad effects of which are not confined to subsequent scientific studies. But certainly the best remedy for both is to be found in mathematics, where there is absolute certainty in the reasoning, and no authority is recognized but that of one’s own intelligence.

I do not share in this reverence for knowledge as such. It all depends on who has the knowledge and what he does with it. That knowledge which adds greatly to character is knowledge so handled as to transform every phase of immediate experience.

I fancy you give me credit for being a more systematic sort of cove than I really am in the matter of limits of significance. What would actually happen would be that I should make out Pt (normal) and say to myself that would be about 50:1; pretty good but as it may not be normal we'd best not be too certain, or 100:1; even allowing that it may not be normal it seems good enough and whether one would be content with that or would require further work would depend on the importance of the conclusion and the difficulty of obtaining suitable experience.

I have attempted to form a judgment as to the conditions for evolution based on the statistical consequences of Mendelian heredity. The most general conclusion is that evolution depends on a certain balance among its factors. There must be a gene mutation, but an excessive rate gives an array of freaks, not evolution; there must be selection, but too severe a process destroys the field of variability, and thus the basis for further advance; prevalence of local inbreeding within a species has extremely important evolutionary consequences, but too close inbreeding leads merely to extinction. A certain amount of crossbreeding is favorable but not too much. In this dependence on balance the species is like a living organism. At all levels of organization life depends on the maintenance of a certain balance among its factors.

I have very often reflected on what it is that really distinguishes the great genius from the common crowd. Here are a few observations I have made. The common individual always conforms to the prevailing opinion and the prevailing fashion; he regards the State in which everything now exists as the only possible one and passively accepts it ail. It does not occur to him that everything, from the shape of the furniture up to the subtlest hypothesis, is decided by the great council of mankind of which he is a member. He wears thin-soled shoes even though the sharp stones of the Street hurt his feet, he allows fashion to dictate to him that the buckles of his shoes must extend as far as the toes even though that means the shoe is often hard to get on. He does not reflect that the form of the shoe depends as much upon him as it does upon the fool who first wore thin shoes on a cracked pavement. To the great genius it always occurs to ask: Could this too not be false! He never gives his vote without first reflecting.

I shall explain a System of the World differing in many particulars from any yet known, answering in all things to the common Rules of Mechanical Motions: This depends upon three Suppositions. First, That all Cœlestial Bodies whatsoever, have an attraction or gravitating power towards their own Centers, whereby they attract not only their own parts, and keep them from flying from them, as we may observe the Earth to do, but that they do also attract all the other Cœlestial bodies that are within the sphere of their activity; and consequently that not only the Sun and Moon have an influence upon the body and motion the Earth, and the Earth upon them, but that Mercury also Venus, Mars, Saturn and Jupiter by their attractive powers, have a considerable influence upon its motion in the same manner the corresponding attractive power of the Earth hath a considerable influence upon every one of their motions also. The second supposition is this, That all bodies whatsoever that are put into a direct and simple motion, will continue to move forward in a streight line, till they are by some other effectual powers deflected and bent into a Motion, describing a Circle, Ellipse, or some other more compounded Curve Line. The third supposition is, That these attractive powers are so much the more powerful in operating, by how much the nearer the body wrought upon is to their own Centers. Now what these several degrees are I have not yet experimentally verified; but it is a notion, which if fully prosecuted as it ought to be, will mightily assist the Astronomer to reduce all the Cœlestial Motions to a certain rule, which I doubt will never be done true without it. He that understands the nature of the Circular Pendulum and Circular Motion, will easily understand the whole ground of this Principle, and will know where to find direction in Nature for the true stating thereof. This I only hint at present to such as have ability and opportunity of prosecuting this Inquiry, and are not wanting of Industry for observing and calculating, wishing heartily such may be found, having myself many other things in hand which I would first compleat and therefore cannot so well attend it. But this I durst promise the Undertaker, that he will find all the Great Motions of the World to be influenced by this Principle, and that the true understanding thereof will be the true perfection of Astronomy.

I speak as a planetary physician whose patient, the living Earth, complains of fever; I see the Earth’s declining health as our most important concern, our very lives depending upon a healthy Earth. Our concern for it must come first, because the welfare of the burgeoning mass of humanity demands a healthy planet.

I will ask you to mark again that rather typical feature of the development of our subject; how so much progress depends on the interplay of techniques, discoveries and new ideas, probably in that order of decreasing importance.

If it is possible to have a linear unit that depends on no other quantity, it would seem natural to prefer it. Moreover, a mensural unit taken from the earth itself offers another advantage, that of being perfectly analogous to all the real measurements that in ordinary usage are also made upon the earth, such as the distance between two places or the area of some tract, for example. It is far more natural in practice to refer geographical distances to a quadrant of a great circle than to the length of a pendulum.

If they don’t depend on true evidence, scientists are no better than gossips.

In all cases of the motion of free material points under the influence of their attractive and repulsive forces, whose intensity depends solely upon distance, the loss in tension is always equal to the gain in vis viva, and the gain in the former equal to the loss in the latter. Hence the sum of the existing tensions and vires vivae is always constant. In this most general form we can distinguish our law as the principle of the conservation of force.

In all cases when a particular agent or cause is to be studied, experiments should be arranged in such a way as to lead if possible to results depending on it alone ; or, if this cannot be done, they should be arranged so as to increase the effects due to the cause to be studied till these so far exceed the unavoidable concomitants, that the latter may be considered as only disturbing, not essentially modifying the effects of the principal agent.

In an age of egoism, it is so difficult to persuade man that of all studies, the most important is that of himself. This is because egoism, like all passions, is blind. The attention of the egoist is directed to the immediate needs of which his senses give notice, and cannot be raised to those reflective needs that reason discloses to us; his aim is satisfaction, not perfection. He considers only his individual self; his species is nothing to him. Perhaps he fears that in penetrating the mysteries of his being he will ensure his own abasement, blush at his discoveries, and meet his conscience. True philosophy, always at one with moral science, tells a different tale. The source of useful illumination, we are told, is that of lasting content, is in ourselves. Our insight depends above all on the state of our faculties; but how can we bring our faculties to perfection if we do not know their nature and their laws! The elements of happiness are the moral sentiments; but how can we develop these sentiments without considering the principle of our affections, and the means of directing them? We become better by studying ourselves; the man who thoroughly knows himself is the wise man. Such reflection on the nature of his being brings a man to a better awareness of all the bonds that unite us to our fellows, to the re-discovery at the inner root of his existence of that identity of common life actuating us all, to feeling the full force of that fine maxim of the ancients: 'I am a man, and nothing human is alien to me.'

In describing a protein it is now common to distinguish the primary, secondary and tertiary structures. The primary structure is simply the order, or sequence, of the amino-acid residues along the polypeptide chains. This was first determined by Sanger using chemical techniques for the protein insulin, and has since been elucidated for a number of peptides and, in part, for one or two other small proteins. The secondary structure is the type of folding, coiling or puckering adopted by the polypeptide chain: the a-helix structure and the pleated sheet are examples. Secondary structure has been assigned in broad outline to a number of librous proteins such as silk, keratin and collagen; but we are ignorant of the nature of the secondary structure of any globular protein. True, there is suggestive evidence, though as yet no proof, that a-helices occur in globular proteins, to an extent which is difficult to gauge quantitatively in any particular case. The tertiary structure is the way in which the folded or coiled polypeptide chains are disposed to form the protein molecule as a three-dimensional object, in space. The chemical and physical properties of a protein cannot be fully interpreted until all three levels of structure are understood, for these properties depend on the spatial relationships between the amino-acids, and these in turn depend on the tertiary and secondary structures as much as on the primary. Only X-ray diffraction methods seem capable, even in principle, of unravelling the tertiary and secondary structures.
Co-author with G. Bodo, H. M. Dintzis, R. G. Parrish, H. Wyckoff, and D. C. Phillips

In the infancy of physical science, it was hoped that some discovery might be made that would enable us to emancipate ourselves from the bondage of gravity, and, at least, pay a visit to our neighbour the moon. The poor attempts of the aeronaut have shewn the hopelessness of the enterprise. The success of his achievement depends on the buoyant power of the atmosphere, but the atmosphere extends only a few miles above the earth, and its action cannot reach beyond its own limits. The only machine, independent of the atmosphere, we can conceive of, would be one on the principle of the rocket. The rocket rises in the air, not from the resistance offered by the atmosphere to its fiery stream, but from the internal reaction. The velocity would, indeed, be greater in a vacuum than in the atmosphere, and could we dispense with the comfort of breathing air, we might, with such a machine, transcend the boundaries of our globe, and visit other orbs.

In the world of science, however, these sentiments have never been of much account. There everything depends on making opinion prevail and dominate; few men are really independent; the majority draws the individual after it.

Increasingly, our leaders must deal with dangers that threaten the entire world, where an understanding of those dangers and the possible solutions depend on a good grasp of science. The ozone layer, the greenhouse effect, acid rain, questions of diet and of heredity--all require scientific literacy. Can Americans choose the proper leaders and support the proper programs if they are scientifically illiterate?

Increasingly, our leaders must deal with dangers that threaten the entire world, where an understanding of those dangers and the possible solutions depends on a good grasp of science. The ozone layer, the greenhouse effect, acid rain, questions of diet and heredity. All require scientific literacy. Can Americans choose the proper leaders and support the proper programs if they themselves are scientifically illiterate? The whole premise of democracy is that it is safe to leave important questions to the court of public opinion—but is it safe to leave them to the court of public ignorance?

Invention depends altogether upon Execution or Organisation, as that is right or wrong, so is the Invention perfect or imperfect.

Is pure science to be regarded as overall beneficial to society? Answer: It depends much on what you consider benefits. If you look at health, long life, transportation, communication, education, you might be tempted to say yes. If you look at the enormous social-economic dislocations, at the prospect of an immense famine in India, brought on by the advances of public health science and nutrition science, at strains on our psyches due to the imbalance between technical developments and our limited ability to adjust to the pace of change, you might be tempted to say no. Clearly, the present state of the world—to which science has contributed much—leaves a great deal to be desired, and much to be feared. So I write down … SCIENCE BENEFICIAL? DOUBTFUL.

It [an ethical problem with in vitro fertilization] depends on whether you're talking ethics from the standpoint of some religious denomination or from just truly religious people. The Jewish or Catholic faiths, for example, have their own rules. But just religious people, who will make very devoted parents, have no problem with in vitro fertilization.

It is a law, that every event depends on the same law.

It is an error to imagine that evolution signifies a constant tendency to increased perfection. That process undoubtedly involves a constant remodeling of the organism in adaptation to new conditions; but it depends on the nature of those conditions whether the direction of the modifications effected shall be upward or downward.

It is as true now, as it was in the days when Werner first drew his far-reaching inferences before his charmed listeners, that on the characteristic phenomena and varying distribution of the grand mineral masses of the rock-formations, almost all that concerns the relative habitability of a land depends.

It is contrary to the usual order of things, that events so harmonious as those of the system of the world, should depend on such diversified agents as are supposed to exist in our artificial arrangements; and there is reason to anticipate a great reduction in the number of undecompounded bodies, and to expect that the analogies of nature will be found conformable to the refined operations of art. The more the phenomena of the universe are studied, the more distinct their connection appears, and the more simple their causes, the more magnificent their design, and the more wonderful the wisdom and power of their Author.

It is high time that laymen abandoned the misleading belief that scientific enquiry is a cold dispassionate enterprise, bleached of imaginative qualities, and that a scientist is a man who turns the handle of discovery; for at every level of endeavour scientific research is a passionate undertaking and the Promotion of Natural Knowledge depends above all on a sortee into what can be imagined but is not yet known.

It is now necessary to indicate more definitely the reason why mathematics not only carries conviction in itself, but also transmits conviction to the objects to which it is applied. The reason is found, first of all, in the perfect precision with which the elementary mathematical concepts are determined; in this respect each science must look to its own salvation .... But this is not all. As soon as human thought attempts long chains of conclusions, or difficult matters generally, there arises not only the danger of error but also the suspicion of error, because since all details cannot be surveyed with clearness at the same instant one must in the end be satisfied with a belief that nothing has been overlooked from the beginning. Every one knows how much this is the case even in arithmetic, the most elementary use of mathematics. No one would imagine that the higher parts of mathematics fare better in this respect; on the contrary, in more complicated conclusions the uncertainty and suspicion of hidden errors increases in rapid progression. How does mathematics manage to rid itself of this inconvenience which attaches to it in the highest degree? By making proofs more rigorous? By giving new rules according to which the old rules shall be applied? Not in the least. A very great uncertainty continues to attach to the result of each single computation. But there are checks. In the realm of mathematics each point may be reached by a hundred different ways; and if each of a hundred ways leads to the same point, one may be sure that the right point has been reached. A calculation without a check is as good as none. Just so it is with every isolated proof in any speculative science whatever; the proof may be ever so ingenious, and ever so perfectly true and correct, it will still fail to convince permanently. He will therefore be much deceived, who, in metaphysics, or in psychology which depends on metaphysics, hopes to see his greatest care in the precise determination of the concepts and in the logical conclusions rewarded by conviction, much less by success in transmitting conviction to others. Not only must the conclusions support each other, without coercion or suspicion of subreption, but in all matters originating in experience, or judging concerning experience, the results of speculation must be verified by experience, not only superficially, but in countless special cases.

It is only by the influence of individuals who can set an example, whom the masses recognize as their leaders, that they can be induced to submit to the labors and renunciations on which the existence of culture depends.

It is true that physics gives a wonderful training in precise, logical thinking-about physics. It really does depend upon accurate reproducible experiments, and upon framing hypotheses with the greatest possible freedom from dogmatic prejudice. And if these were the really important things in life, physics would be an essential study for everybody.

It was his [Leibnitz’s] love of method and order, and the conviction that such order and harmony existed in the real world, and that our success in understanding it depended upon the degree and order which we could attain in our own thoughts, that originally was probably nothing more than a habit which by degrees grew into a formal rule. This habit was acquired by early occupation with legal and mathematical questions. We have seen how the theory of combinations and arrangements of elements had a special interest for him. We also saw how mathematical calculations served him as a type and model of clear and orderly reasoning, and how he tried to introduce method and system into logical discussions, by reducing to a small number of terms the multitude of compound notions he had to deal with. This tendency increased in strength, and even in those early years he elaborated the idea of a general arithmetic, with a universal language of symbols, or a characteristic which would be applicable to all reasoning processes, and reduce philosophical investigations to that simplicity and certainty which the use of algebraic symbols had introduced into mathematics.
A mental attitude such as this is always highly favorable for mathematical as well as for philosophical investigations. Wherever progress depends upon precision and clearness of thought, and wherever such can be gained by reducing a variety of investigations to a general method, by bringing a multitude of notions under a common term or symbol, it proves inestimable. It necessarily imports the special qualities of number—viz., their continuity, infinity and infinite divisibility—like mathematical quantities—and destroys the notion that irreconcilable contrasts exist in nature, or gaps which cannot be bridged over. Thus, in his letter to Arnaud, Leibnitz expresses it as his opinion that geometry, or the philosophy of space, forms a step to the philosophy of motion—i.e., of corporeal things—and the philosophy of motion a step to the philosophy of mind.

It will be found that everything depends on the composition of the forces with which the particles of matter act upon one another; and from these forces, as a matter of fact, all phenomena of Nature take their origin.

Jefferson refused to pin his hopes on the occasional success of honest and unambitious men; on the contrary, the great danger was that philosophers would be lulled into complacence by the accidental rise of a Franklin or a Washington. Any government which made the welfare of men depend on the character of their governors was an illusion.

Just as the arts of tanning and dyeing were practiced long before the scientific principles upon which they depend were known, so also the practice of Chemical Engineering preceded any analysis or exposition of the principles upon which such practice is based.