Academies have been instituted to guard the avenues of their languages, to retain fugitives, and repulse intruders; but their vigilance and activity have hitherto been vain; sounds are too volatile and subtile for legal restraints; to enchain syllables, and to lash the wind, are equally the undertakings of pride, unwilling to measure its desires by its strength.

Clearly it is not reason that has failed. What has failed—as it has always failed—is the attempt to achieve certainty, to reach an absolute, to find the course of human events to a final end. ... It is not reason that has promised to eliminate risk in human undertakings; it is the emotional needs of men.

I undertake my scientific research with the confident assumption that the earth follows the laws of nature which God established at creation. … My studies are performed with the confidence that God will not capriciously confound scientific results by “slipping in” a miracle.

Let us now recapitulate all that has been said, and let us conclude that by hermetically sealing the vials, one is not always sure to prevent the birth of the animals in the infusions, boiled or done at room temperature, if the air inside has not felt the ravages of fire. If, on the contrary, this air has been powerfully heated, it will never allow the animals to be born, unless new air penetrates from outside into the vials. This means that it is indispensable for the production of the animals that they be provided with air which has not felt the action of fire. And as it would not be easy to prove that there were no tiny eggs disseminated and floating in the volume of air that the vials contain, it seems to me that suspicion regarding these eggs continues, and that trial by fire has not entirely done away with fears of their existence in the infusions. The partisans of the theory of ovaries will always have these fears and will not easily suffer anyone's undertaking to demolish them.

We do not ask what hope of gain makes a little bird warble, since we know that it takes delight in singing because it is for that very singing that the bird was made, so there is no need to ask why the human mind undertakes such toil in seeking out these secrets of the heavens. ... And just as other animals, and the human body, are sustained by food and drink, so the very spirit of Man, which is something distinct from Man, is nourished, is increased, and in a sense grows up on this diet of knowledge, and is more like the dead than the living if it is touched by no desire for these things.

What caused me to undertake the catalog was the nebula I discovered above the southern horn of Taurus on September 12, 1758, while observing the comet of that year. ... This nebula had such a resemblance to a comet in its form and brightness that I endeavored to find others, so that astronomers would not confuse these same nebulae with comets just beginning to shine. I observed further with suitable refractors for the discovery of comets, and this is the purpose I had in mind in compiling the catalog.
After me, the celebrated Herschel published a catalog of 2000 which he has observed. This unveiling the sky, made with instruments of great aperture, does not help in the perusal of the sky for faint comets. Thus my object is different from his, and I need only nebulae visible in a telescope of two feet [focal length].

[Decoding the human genome sequence] is the most significant undertaking that we have mounted so far in an organized way in all of science. I believe that reading our blueprints, cataloguing our own instruction book, will be judged by history as more significant than even splitting the atom or going to the moon.