[Decoding the human genome sequence] is the most significant undertaking that we have mounted so far in an organized way in all of science. I believe that reading our blueprints, cataloguing our own instruction book, will be judged by history as more significant than even splitting the atom or going to the moon.

A just society must strive with all its might to right wrongs even if righting wrongs is a highly perilous undertaking. But if it is to survive, a just society must be strong and resolute enough to deal swiftly and relentlessly with those who would mistake its good will for weakness.

A vision of the whole of life!. Could any human undertaking be ... more grandiose? This attempt stands without rival as the most audacious enterprise in which the mind of man has ever engaged ... Here is man, surrounded by the vastness of a universe in which he is only a tiny and perhaps insignificant part—and he wants to understand it.

Academies have been instituted to guard the avenues of their languages, to retain fugitives, and repulse intruders; but their vigilance and activity have hitherto been vain; sounds are too volatile and subtile for legal restraints; to enchain syllables, and to lash the wind, are equally the undertakings of pride, unwilling to measure its desires by its strength.

An undertaking of great magnitude and importance, the successful accomplishment of which, in so comparatively short a period, notwithstanding the unheard of unestimable difficulties and impediments which had to be encountered and surmounted, in an almost unexplored and uninhabited wilderness … evinced on your part a moral courage and an undaunted spirit and combination of science and management equally exciting our admiration and deserving our praise.
(In recognition of his achievement building the Rideau Canal.)

But by far the greatest obstacle to the progress of science and to the undertaking of new tasks and provinces therein is found in this—that men despair and think things impossible.

Clearly it is not reason that has failed. What has failed—as it has always failed—is the attempt to achieve certainty, to reach an absolute, to find the course of human events to a final end. ... It is not reason that has promised to eliminate risk in human undertakings; it is the emotional needs of men.

Endowed with two qualities, which seemed incompatible with each other, a volcanic imagination and a pertinacity of intellect which the most tedious numerical calculations could not daunt, Kepler conjectured that the movements of the celestial bodies must be connected together by simple laws, or, to use his own expression, by harmonic laws. These laws he undertook to discover. A thousand fruitless attempts, errors of calculation inseparable from a colossal undertaking, did not prevent him a single instant from advancing resolutely toward the goal of which he imagined he had obtained a glimpse. Twenty-two years were employed by him in this investigation, and still he was not weary of it! What, in reality, are twenty-two years of labor to him who is about to become the legislator of worlds; who shall inscribe his name in ineffaceable characters upon the frontispiece of an immortal code; who shall be able to exclaim in dithyrambic language, and without incurring the reproach of anyone, “The die is cast; I have written my book; it will be read either in the present age or by posterity, it matters not which; it may well await a reader, since God has waited six thousand years for an interpreter of his words.”

I undertake my scientific research with the confident assumption that the earth follows the laws of nature which God established at creation. … My studies are performed with the confidence that God will not capriciously confound scientific results by “slipping in” a miracle.

It is high time that laymen abandoned the misleading belief that scientific enquiry is a cold dispassionate enterprise, bleached of imaginative qualities, and that a scientist is a man who turns the handle of discovery; for at every level of endeavour scientific research is a passionate undertaking and the Promotion of Natural Knowledge depends above all on a sortee into what can be imagined but is not yet known.

It is the task of science, as a collective human undertaking, to describe from the external side, (on which alone agreement is possible), such statistical regularity as there is in a world “in which every event has a unique aspect, and to indicate where possible the limits of such description. It is not part of its task to make imaginative interpretation of the internal aspect of reality—what it is like, for example, to be a lion, an ant or an ant hill, a liver cell, or a hydrogen ion. The only qualification is in the field of introspective psychology in which each human being is both observer and observed, and regularities may be established by comparing notes. Science is thus a limited venture. It must act as if all phenomena were deterministic at least in the sense of determinable probabilities. It cannot properly explain the behaviour of an amoeba as due partly to surface and other physical forces and partly to what the amoeba wants to do, with out danger of something like 100 per cent duplication. It must stick to the former. It cannot introduce such principles as creative activity into its interpretation of evolution for similar reasons. The point of view indicated by a consideration of the hierarchy of physical and biological organisms, now being bridged by the concept of the gene, is one in which science deliberately accepts a rigorous limitation of its activities to the description of the external aspects of events. In carrying out this program, the scientist should not, however, deceive himself or others into thinking that he is giving an account of all of reality. The unique inner creative aspect of every event necessarily escapes him.

Let us now recapitulate all that has been said, and let us conclude that by hermetically sealing the vials, one is not always sure to prevent the birth of the animals in the infusions, boiled or done at room temperature, if the air inside has not felt the ravages of fire. If, on the contrary, this air has been powerfully heated, it will never allow the animals to be born, unless new air penetrates from outside into the vials. This means that it is indispensable for the production of the animals that they be provided with air which has not felt the action of fire. And as it would not be easy to prove that there were no tiny eggs disseminated and floating in the volume of air that the vials contain, it seems to me that suspicion regarding these eggs continues, and that trial by fire has not entirely done away with fears of their existence in the infusions. The partisans of the theory of ovaries will always have these fears and will not easily suffer anyone's undertaking to demolish them.

Lord Kelvin had, in a manner hardly and perhaps never equalled before, except by Archimedes, the power of theorizing on the darkest, most obscure, and most intimate secrets of Nature, and at the same time, and almost in the same breath, carrying out effectively and practically some engineering feat, or carrying to a successful issue some engineering invention. He was one of the leaders in the movement which has compelled all modern engineers worthy of the name to be themselves men not merely of practice, but of theory, to carry out engineering undertakings in the spirit of true scientific inquiry and with an eye fixed on the rapidly growing knowledge of the mechanics of Nature, which can only be acquired by the patient work of physicists and mathematicians in their laboratories and studies.

Science is a dynamic undertaking directed to lowering the degree of the empiricism involved in solving problems; or, if you prefer, science is a process of fabricating a web of interconnected concepts and conceptual schemes arising from experiments and observations and fruitful of further experiments and observations.

We do not ask what hope of gain makes a little bird warble, since we know that it takes delight in singing because it is for that very singing that the bird was made, so there is no need to ask why the human mind undertakes such toil in seeking out these secrets of the heavens. ... And just as other animals, and the human body, are sustained by food and drink, so the very spirit of Man, which is something distinct from Man, is nourished, is increased, and in a sense grows up on this diet of knowledge, and is more like the dead than the living if it is touched by no desire for these things.

What caused me to undertake the catalog was the nebula I discovered above the southern horn of Taurus on September 12, 1758, while observing the comet of that year. ... This nebula had such a resemblance to a comet in its form and brightness that I endeavored to find others, so that astronomers would not confuse these same nebulae with comets just beginning to shine. I observed further with suitable refractors for the discovery of comets, and this is the purpose I had in mind in compiling the catalog.
After me, the celebrated Herschel published a catalog of 2000 which he has observed. This unveiling the sky, made with instruments of great aperture, does not help in the perusal of the sky for faint comets. Thus my object is different from his, and I need only nebulae visible in a telescope of two feet [focal length].

Whereas there is nothing more necessary for promoting the improvement of Philosophical Matters, than the communicating to such, as apply their Studies and Endeavours that way, such things as are discovered or put in practice by others; it is therefore thought fit to employ the Press, as the most proper way to gratifie those, whose engagement in such Studies, and delight in the advancement of Learning and profitable Discoveries, doth entitle them to the knowledge of what this Kingdom, or other parts of the World, do, from time to time, afford as well of the progress of the Studies, Labours, and attempts of the Curious and learned in things of this kind, as of their compleat Discoveries and performances: To the end, that such Productions being clearly and truly communicated, desires after solid and usefull knowledge may be further entertained, ingenious Endeavours and Undertakings cherished, and those, addicted to and conversant in such matters, may be invited and encouraged to search, try, and find out new things, impart their knowledge to one another, and contribute what they can to the Grand design of improving Natural knowledge, and perfecting all Philosophical Arts, and Sciences. All for the Glory of God, the Honour and Advantage of these Kingdoms, and the Universal Good of Mankind.