Genome Quotes (15 quotes)
[Decoding the human genome sequence] is the most significant undertaking that we have mounted so far in an organized way in all of science. I believe that reading our blueprints, cataloguing our own instruction book, will be judged by history as more significant than even splitting the atom or going to the moon.
[Describing a freshman seminar titled “How the Tabby Cat Got Her Stripes or The Silence of the Genes”:] The big idea we start with is: “How is the genome interpreted, and how are stable decisions that affect gene expression inherited from one cell to the next? This is one of the most competitive areas of molecular biology at the moment, and the students are reading papers that in some instances were published this past year. As a consequence, one of the most common answers I have to give to their questions is, “We just don't know.”
A DNA sequence for the genome of bacteriophage ΦX174 of approximately 5,375 nucleotides has been determined using the rapid and simple “plus and minus” method. The sequence identifies many of the features responsible for the production of the proteins of the nine known genes of the organism, including initiation and termination sites for the proteins and RNAs. Two pairs of genes are coded by the same region of DNA using different reading frames.
[Paper co-author]
[Paper co-author]
As was predicted at the beginning of the Human Genome Project, getting the sequence will be the easy part as only technical issues are involved. The hard part will be finding out what it means, because this poses intellectual problems of how to understand the participation of the genes in the functions of living cells.
Domesticated biotechnology, once it gets into the hands of housewives and children, will give us an explosion of diversity of new living creatures … New lineages will proliferate to replace those that monoculture farming and deforestation have destroyed. Designing genomes will be a personal thing, a new art form as creative as painting or sculpture. Few of the new creations will be masterpieces, but a great many will bring joy to their creators and variety to our fauna and flora.
I would like to see us continue to explore space. There's just a lot for us to keep learning. I think it’s a good investment, so on my list of things that I want our country to invest in—in terms of research and innovation and science, basic science, exploring space, exploring our oceans, exploring our genome—we’re at the brink of all kinds of new information. Let's not back off now!
President Clinton at the Human Genome Announcement at the White House (20 Jun 2000), with Francis S. Collins (left) and Craig Ventner. (source)
It is now conceivable that our children's children will know the term cancer only as a constellation of stars. [Speaking on the Human Genome Project's progress.]
It is tautological to say that an organism is adapted to its environment. It is even tautological to say that an organism is physiologically adapted to its environment. However, just as in the case of many morphological characters, it is unwarranted to conclude that all aspects of the physiology of an organism have evolved in reference to a specific milieu. It is equally gratuitous to assume that an organism will inevitably show physiological specializations in its adaptation to a particular set of conditions. All that can be concluded is that the functional capacities of an organism are sufficient to have allowed persistence within its environment. On one hand, the history of an evolutionary line may place serious constraints upon the types of further physiological changes that are readily feasible. Some changes might require excessive restructuring of the genome or might involve maladaptive changes in related functions. On the other hand, a taxon which is successful in occupying a variety of environments may be less impressive in individual physiological capacities than one with a far more limited distribution.
Just the Human Genome Project alone is the Full Employment Act for bioethicists.
Mapping the human genome has been compared with putting a man on the moon, but I believe it is more than that. This is the outstanding achievement not only of our lifetime, but in terms of human history. A few months ago I compared the project to the invention of the wheel. On reflection, it is more than that. I can well imagine technology making the wheel obsolete. But this code is the essence of mankind, and as long as humans exists, this code is going to be important and will be used.
Only time and money stand between us and knowing the composition of every gene in the human genome.
The microbial global brain—gifted with long-range transport, data trading, genetic variants … and the ability to reinvent genomes—began its operations some 91 trillion bacterial generations before the birth of the Internet. Ancient bacteria, if they functioned like those today, had mastered the art of worldwide information exchange. … The earliest microorganisms would have used planet-sweeping currents of wind and water to carry the scraps of genetic code…
These results demonstrate that there is a new polymerase inside the virions of RNA tumour viruses. It is not present in supernatents of normal cells but is present in virions of avian sarcoma and leukemia RNA tumour viruses. The polymerase seems to catalyse the incorporation of deoxyrinonucleotide triphosphates into DNA from an RNA template. Work is being performed to characterize further the reaction and the product. If the present results and Baltimore's results with Rauscher leukemia virus are upheld, they will constitute strong evidence that the DNA proviruses have a DNA genome when they are in virions. This result would have strong implications for theories of viral carcinogenesis and, possibly, for theories of information transfer in other biological systems. [Co-author with American virologist Satoshi Mizutani]
President Clinton at the Human Genome Announcement at the White House (20 Jun 2000), with Francis S. Collins (left) and Craig Ventner. (source)
We are here to celebrate the completion of the first survey of the entire human genome. Without a doubt, this is the most important, most wondrous map ever produced by human kind.
We share half our genes with the banana. [After the announcement Jun 2000 that a working draft of the genetic sequence of humans had been completed by the Human Genome Project.]