'Normal science' means research firmly based upon one or more past scientific achievements, achievements that some particular scientific community acknowledges for a time as supplying the foundation for its further practice.

...it is not to be taken in the sense of our day, which we reckon by the course of the sun; but it must have another meaning, applicable to the
three days mentioned before the creation of the heavenly bodies.

1839—The fermentation satire
THE MYSTERY OF ALCOHOLIC FERMENTATION RESOLVED
(Preliminary Report by Letter) Schwindler
I am about to develop a new theory of wine fermentation … Depending on the weight, these seeds carry fermentation to completion somewhat less than as in the beginning, which is understandable … I shall develop a new theory of wine fermentation [showing] what simple means Nature employs in creating the most amazing phenomena. I owe it to the use of an excellent microscope designed by Pistorius.
When brewer’s yeast is mixed with water the microscope reveals that the yeast dissolves into endless small balls, which are scarcely 1/800th of a line in diameter … If these small balls are placed in sugar water, it can be seen that they consist of the eggs of animals. As they expand, they burst, and from them develop small creatures that multiply with unbelievable rapidity in a most unheard of way. The form of these animals differs from all of the 600 types described up until now. They possess the shape of a Beinsdorff still (without the cooling apparatus). The head of the tube is a sort of proboscis, the inside of which is filled with fine bristles 1/2000th of a line long. Teeth and eyes are not discernible; however, a stomach, intestinal canal, anus (a rose red dot), and organs for secretion of urine are plainly discernible. From the moment they are released from the egg one can see these animals swallow the sugar from the solution and pass it to the stomach. It is digested immediately, a process recognized easily by the resultant evacuation of excrements. In a word, these infusors eat sugar, evacuate ethyl alcohol from the intestinal canal, and carbon dioxide from the urinary organs. The bladder, in the filled state, has the form of a champagne bottle; when empty, it is a small button … As soon as the animals find no more sugar present, they eat each other up, which occurs through a peculiar manipulation; everything is digested down to the eggs which pass unchanged through the intestinal canal. Finally, one again fermentable yeast, namely the seed of the animals, which remain over.

A stands for atom; it is so small No one has ever seen it at all.
B stands for bomb; the bombs are much bigger,
So, brother, do not be too fast on the trigger.
H has become a most ominous letter.
It means something bigger if not something better.

Boss: Dilbert, You have been chosen to design the world’s safest nuclear power plant.
Dilbert: This is the great assignment that any engineer could hope for. I'm flattered by the trust you have in me.
Boss: By “safe” I mean “not near my house.”

Branches or types are characterized by the plan of their structure,
Classes, by the manner in which that plan is executed, as far as ways and means are concerned,
Orders, by the degrees of complication of that structure,
Families, by their form, as far as determined by structure,
Genera, by the details of the execution in special parts, and
Species, by the relations of individuals to one another and to the world in which they live, as well as by the proportions of their parts, their ornamentation, etc.

Conclusions
I. A curve has been found representing the frequency distribution of standard deviations of samples drawn from a normal population.
II. A curve has been found representing the frequency distribution of values of the means of such samples, when these values are measured from the mean of the population in terms of the standard deviation of the sample…
IV. Tables are given by which it can be judged whether a series of experiments, however short, have given a result which conforms to any required standard of accuracy or whether it is necessary to continue the investigation.

Die Grenzen meiner Sprache bedeuten die Grenzen meiner Welt.
The limits of my language mean the limits of my world.

Die Wissenschaft ist ein Land, welches die Eigenschaft hat, um so mehr Menschen beherbergen zu können, je mehr Bewohner sich darin sammeln; sie ist ein Schatz, der um so grösser wird, je mehr man ihn teilt. Darum kann jeder von uns in seiner Art seine Arbeit tun, und die Gemeinsamkeit bedeutet nicht Gleichförmigkeit.
Science is one land, having the ability to accommodate even more people, as more residents gather in it; it is a treasure that is the greater the more it is shared. Because of that, each of us can do his work in his own way, and the common ground does not mean conformity.

Dilbert: Wow! According to my computer simulation, it should be possible to create new life forms from common household chemicals
Dogbert: This raises some thorny issues.
Dilbert: You mean legal, ethical and religious issues?
Dogbert: I was thinking about parking spaces.

Le savant n’étudie pas la nature parce que cela est utile; il l’étudie parce qu’il y prend plaisir et il y prend plaisir parce qu’elle est belle. Si la nature n’était pas belle, elle ne vaudrait pas la peine d’être connue, la vie ne vaudrait pas la peine d’être vécue.
The scientist does not study nature because it is useful to do so. He studies it because he takes pleasure in it, and he takes pleasure in it because it is beautiful. If nature were not beautiful, it would not be worth knowing, and life would not be worth living. I am not speaking, of course, of the beauty which strikes the senses, of the beauty of qualities and appearances. I am far from despising this, but it has nothing to do with science. What I mean is that more intimate beauty which comes from the harmonious order of its parts, and which a pure intelligence can grasp.

Les grands ponts étant … des monuments qui peuvent servir à faire connoître la magnificence et le génie d’une nation, on ne sauroit trop s’occuper des moyens d’en perfectionner l’architecture, qui peut d’ailleurs être susceptible de variété, en conservant toujours, dans les formes et la décoration, le caractere de solidité qui lui est propre.
Great bridges being monuments which serve to make known the grandeur and genius of a nation, we cannot pay too much attention to means for perfecting their architecture; this may be varied in treatment, but there must ever be conserved, in form and in decoration, the indispensable character of solidity.

Mathematical truth has validity independent of place, personality, or human authority. Mathematical relations are not established, nor can they be abrogated, by edict. The multiplication table is international and permanent, not a matter of convention nor of relying upon authority of state or church. The value of π is not amenable to human caprice. The finding of a mathematical theorem may have been a highly romantic episode in the personal life of the discoverer, but it cannot be expected of itself to reveal the race, sex, or temperament of this discoverer. With modern means of widespread communication even mathematical notation tends to be international despite all nationalistic tendencies in the use of words or of type.

Parkinson's Third Law: Expansion means complexity, and complexity decay.

Question: On freezing water in a glass tube, the tube sometimes breaks. Why is this? An iceberg floats with 1,000,000 tons of ice above the water line. About how many tons are below the water line?
Answer: The water breaks the tube because of capallarity. The iceberg floats on the top because it is lighter, hence no tons are below the water line. Another reason is that an iceberg cannot exceed 1,000,000 tons in weight: hence if this much is above water, none is below. Ice is exceptional to all other bodies except bismuth. All other bodies have 1090 feet below the surface and 2 feet extra for every degree centigrade. If it were not for this, all fish would die, and the earth be held in an iron grip.
P.S.—When I say 1090 feet, I mean 1090 feet per second.

Responding to the Bishop of Oxford, Samuel Wilberforce's question whether he traced his descent from an ape on his mother's or his father's side:
If then, said I, the question is put to me would I rather have a miserable ape for a grandfather or a man highly endowed by nature and possessing great means and influence and yet who employs those faculties for the mere purpose of introducing ridicule into a grave scientific discussion—I unhesitatingly affirm my preference for the ape.

Trimming consists of clipping off little bits here and there from those observations which differ most in excess from the mean, and in sticking them onto those which are too small; a species of 'equitable adjustment,' as a radical would term it, which cannot be admitted in science.

Wenn sich für ein neues Fossil kein, auf eigenthümliche Eigenschaften desselben hinweisender, Name auffinden lassen Will; als in welchem Falle ich mich bei dem gegenwärtigen zu befinden gestehe; so halte ich es für besser, eine solche Benennung auszuwählen, die an sich gar nichts sagt, und folglich auch zu keinen unrichtigen Begriffen Anlass geben kann. Diesem zufolge will ich den Namen für die gegenwärtige metallische Substanz, gleichergestalt wie bei dem Uranium geschehen, aus der Mythologie, und zwar von den Ursöhnen der Erde, den Titanen, entlehnen, und benenne also dieses neue Metallgeschlecht: Titanium.
Wherefore no name can be found for a new fossil [element] which indicates its peculiar and characteristic properties (in which position I find myself at present), I think it is best to choose such a denomination as means nothing of itself and thus can give no rise to any erroneous ideas. In consequence of this, as I did in the case of Uranium, I shall borrow the name for this metallic substance from mythology, and in particular from the Titans, the first sons of the earth. I therefore call this metallic genus TITANIUM.

[Defining Organism] That in which every part is at once means and end.

[When asked “Dr. Einstein, why is it that when the mind of man has stretched so far as to discover the structure of the atom we have been unable to devise the political means to keep the atom from destroying us?”] That is simple, my friend. It is because politics is more difficult than physics.

A general course in mathematics should be required of all officers for its practical value, but no less for its educational value in training the mind to logical forms of thought, in developing the sense of absolute truthfulness, together with a confidence in the accomplishment of definite results by definite means.

A bird maintains itself in the air by imperceptible balancing, when near to the mountains or lofty ocean crags; it does this by means of the curves of the winds which as they strike against these projections, being forced to preserve their first impetus bend their straight course towards the sky with divers revolutions, at the beginning of which the birds come to a stop with their wings open, receiving underneath themselves the continual buffetings of the reflex courses of the winds.

A chess problem is genuine mathematics, but it is in some way “trivial” mathematics. However, ingenious and intricate, however original and surprising the moves, there is something essential lacking. Chess problems are unimportant. The best mathematics is serious as well as beautiful—“important” if you like, but the word is very ambiguous, and “serious” expresses what I mean much better.

A closer look at the course followed by developing theory reveals for a start that it is by no means as continuous as one might expect, but full of breaks and at least apparently not along the shortest logical path. Certain methods often afforded the most handsome results only the other day, and many might well have thought that the development of science to infinity would consist in no more than their constant application. Instead, on the contrary, they suddenly reveal themselves as exhausted and the attempt is made to find other quite disparate methods. In that event there may develop a struggle between the followers of the old methods and those of the newer ones. The former's point of view will be termed by their opponents as out-dated and outworn, while its holders in turn belittle the innovators as corrupters of true classical science.

A conflict arises when a religious community insists on the absolute truthfulness of all statements recorded in the Bible. This means an intervention on the part of religion into the sphere of science; this is where the struggle of the Church against the doctrines of Galileo and Darwin belongs. On the other hand, representatives of science have often made an attempt to arrive at fundamental judgments with respect to values and ends on the basis of scientific method, and in this way have set themselves in opposition to religion. These conflicts have all sprung from fatal errors.

A definition of what we mean by “probability”. … The German Dictionary by Jakob and Wilhelm Grimm gives us detailed information: The Latin term “probabilis”, we are told, was at one time translated by “like truth”, or, by “with an appearance of truth” (“mit einem Schein der Wahrheit”). Only since the middle of the seventeenth century has it been rendered by “wahrscheinlich” (lit. truth-resembling).

A few days afterwards, I went to him [the same actuary referred to in another quote] and very gravely told him that I had discovered the law of human mortality in the Carlisle Table, of which he thought very highly. I told him that the law was involved in this circumstance. Take the table of the expectation of life, choose any age, take its expectation and make the nearest integer a new age, do the same with that, and so on; begin at what age you like, you are sure to end at the place where the age past is equal, or most nearly equal, to the expectation to come. “You don’t mean that this always happens?”—“Try it.” He did try, again and again; and found it as I said. “This is, indeed, a curious thing; this is a discovery!” I might have sent him about trumpeting the law of life: but I contented myself with informing him that the same thing would happen with any table whatsoever in which the first column goes up and the second goes down.

A first step in the study of civilization is to dissect it into details, and to classify these in their proper groups. Thus, in examining weapons, they are to be classed under spear, club, sling, bow and arrow, and so forth; among textile arts are to be ranged matting, netting, and several grades of making and weaving threads; myths are divided under such headings as myths of sunrise and sunset, eclipse-myths, earthquake-myths, local myths which account for the names of places by some fanciful tale, eponymic myths which account for the parentage of a tribe by turning its name into the name of an imaginary ancestor; under rites and ceremonies occur such practices as the various kinds of sacrifice to the ghosts of the dead and to other spiritual beings, the turning to the east in worship, the purification of ceremonial or moral uncleanness by means of water or fire. Such are a few miscellaneous examples from a list of hundreds … To the ethnographer, the bow and arrow is the species, the habit of flattening children’s skulls is a species, the practice of reckoning numbers by tens is a species. The geographical distribution of these things, and their transmission from region to region, have to be studied as the naturalist studies the geography of his botanical and zoological species.

A great discovery solves a great problem, but there is a grain of discovery in the solution of any problem. Your problem may be modest, but if it challenges your curiosity and brings into play your inventive faculties, and if you solve it by your own means, you may experience the tension and enjoy the triumph of discovery.

A great surgeon performs operations for stone by a single method; later he makes a statistical summary of deaths and recoveries, and he concludes from these statistics that the mortality law for this operation is two out of five. Well, I say that this ratio means literally nothing scientifically and gives us no certainty in performing the next operation; for we do not know whether the next case will be among the recoveries or the deaths. What really should be done, instead of gathering facts empirically, is to study them more accurately, each in its special determinism. We must study cases of death with great care and try to discover in them the cause of mortal accidents so as to master the cause and avoid the accidents.

A Law of Nature, (Lex Naturalis) is a Precept, or general Rule, found out by Reason, by which a man is forbidden to do, that, which is destructive of his life, or taketh away the means of preserving the same; and to omit, that, by which he thinketh it may be best preserved

A linguist would be shocked to learn that if a set is not closed this does not mean that it is open, or again that “E is dense in E” does not mean the same thing as “E is dense in itself”.

A man has a very insecure tenure of a property which another can carry away with his eyes. A few months reduced me to the cruel necessity either of destroying my machine, or of giving it to the public. To destroy it, I could not think of; to give up that for which I had laboured so long, was cruel. I had no patent, nor the means of purchasing one. In preference to destroying, I gave it to the public.
[On his inability to keep for himself a profitable income from his invention of the Spinning Mule.]

A man is flying in a hot air balloon and realizes he is lost. He reduces height, spots a man down below and asks,“Excuse me, can you help me? I promised to return the balloon to its owner, but I don’t know where I am.”
The man below says: “You are in a hot air balloon, hovering approximately 350 feet above mean sea level and 30 feet above this field. You are between 40 and 42 degrees north latitude, and between 58 and 60 degrees west longitude.”
“You must be an engineer,” says the balloonist.
“I am,” replies the man.“How did you know?”
“Well,” says the balloonist, “everything you have told me is technically correct, but I have no idea what to make of your information, and the fact is I am still lost.”
The man below says, “You must be a manager.”
“I am,” replies the balloonist,“but how did you know?”
“Well,” says the engineer,“you don’t know where you are, or where you are going. You have made a promise which you have no idea how to keep, and you expect me to solve your problem.The fact is you are in the exact same position you were in before we met, but now it is somehow my fault.”

A metaphysician is one who, when you remark that twice two makes four, demands to know what you mean by twice, what by two, what by makes, and what by four. For asking such questions metaphysicians are supported in oriental luxury in the universities, and respected as educated and intelligent men.

A Native American elder once described his own inner struggles in this manner: Inside of me there are two dogs. One of the dogs is mean and evil. The other dog is good. The mean dog fights the good dog all the time. When asked which dog wins, he reflected for a moment and replied, The one I feed the most.

A principle of induction would be a statement with the help of which we could put inductive inferences into a logically acceptable form. In the eyes of the upholders of inductive logic, a principle of induction is of supreme importance for scientific method: “... this principle”, says Reichenbach, “determines the truth of scientific theories. To eliminate it from science would mean nothing less than to deprive science of the power to decide the truth or falsity of its theories. Without it, clearly, science would no longer have the right to distinguish its theories from the fanciful and arbitrary creations of the poet’s mind.” Now this principle of induction cannot be a purely logical truth like a tautology or an analytic statement. Indeed, if there were such a thing as a purely logical principle of induction, there would be no problem of induction; for in this case, all inductive inferences would have to be regarded as purely logical or tautological transformations, just like inferences in inductive logic. Thus the principle of induction must be a synthetic statement; that is, a statement whose negation is not self-contradictory but logically possible. So the question arises why such a principle should be accepted at all, and how we can justify its acceptance on rational grounds.

A procession of the damned. By the damned, I mean the excluded. We shall have a procession of data that Science has excluded.

A rock or stone is not a subject that, of itself, may interest a philosopher to study; but, when he comes to see the necessity of those hard bodies, in the constitution of this earth, or for the permanency of the land on which we dwell, and when he finds that there are means wisely provided for the renovation of this necessary decaying part, as well as that of every other, he then, with pleasure, contemplates this manifestation of design, and thus connects the mineral system of this earth with that by which the heavenly bodies are made to move perpetually in their orbits.

A star is drawing on some vast reservoir of energy by means unknown to us. This reservoir can scarcely be other than the subatomic energy which, it is known exists abundantly in all matter; we sometimes dream that man will one day learn how to release it and use it for his service. The store is well nigh inexhaustible, if only it could be tapped. There is sufficient in the Sun to maintain its output of heat for 15 billion years.

A State without the means of some change is without the means of its conservation.

A teacher of mathematics has a great opportunity. If he fills his allotted time with drilling his students in routine operations he kills their interest, hampers their intellectual development, and misuses his opportunity. But if he challenges the curiosity of his students by setting them problems proportionate to their knowledge, and helps them to solve their problems with stimulating questions, he may give them a taste for, and some means of, independent thinking.

A tidy laboratory means a lazy chemist.

A time will come when science will transform [our bodies] by means which we cannot conjecture... And then, the earth being small, mankind will migrate into space, and will cross the airless Saharas which separate planet from planet, and sun from sun. The earth will become a Holy Land which will be visited by pilgrims from all quarters of the universe.

About ten months ago [1609] a report reached my ears that a certain Fleming [Hans Lippershey] had constructed a spyglass, by means of which visible objects, though very distant from the eye of the observer, were distinctly seen as if nearby... Of this truly remarkable effect several experiences were related, to which some persons gave credence while others denied them. A few days later the report was confirmed to me in a letter from a noble Frenchman at Paris, Jacques Badovere, which caused me to apply myself wholeheartedly to enquire into the means by which I might arrive at the invention of a similar instrument. This I did shortly afterwards, my basis being the theory of refraction. First I prepared a tube of lead, at the ends of which I fitted two glass lenses, both plane on one side while on the other side one was spherically convex and the other concave.

About the year 1772, being then an apprentice to a wheel-wright, or wagon maker, I laboured to discover some means of propelling land carriages without animal power. … one of my brothers [told me of] blacksmith’s boys, who, for amusement, had stopped up the touch hole of a gun barrel, then put in about a gill of water, and rammed down a tight wad; after which they put the breech in the smith’s fire, when it discharged itself with as loud a crack as if it had been loaded with powder. It immediately occurred to me, that here was the power to propel any wagon, if I could only apply it.

Absolute, true, and mathematical time, in and of itself and of its own nature, without reference to anything external, flows uniformly and by another name is called duration. Relative, apparent, and common time is any sensible and external measure (precise or imprecise) of duration by means of motion; such as a measure—for example, an hour, a day, a month, a year—is commonly used instead of true time.

Across the road from my cabin was a huge clear-cut—hundreds of acres of massive spruce stumps interspersed with tiny Douglas firs—products of what they call “Reforestation,” which I guess makes the spindly firs en masse a “Reforest,” which makes an individual spindly fir a “Refir,” which means you could say that Weyerhauser, who owns the joint, has Refir Madness, since they think that sawing down 200-foot-tall spruces and replacing them with puling 2-foot Refirs is no different from farming beans or corn or alfalfa. They even call the towering spires they wipe from the Earth's face forever a “crop”--as if they'd planted the virgin forest! But I'm just a fisherman and may be missing some deeper significance in their nomenclature and stranger treatment of primordial trees.

Aeroplanes are not designed by science, but by art in spite of some pretence and humbug to the contrary. I do not mean to suggest that engineering can do without science, on the contrary, it stands on scientific foundations, but there is a big gap between scientific research and the engineering product which has to be bridged by the art of the engineer.

Agnosticism is of the essence of science, whether ancient or modern. It simply means that a man shall not say he knows or believes that for which he has no grounds for professing to believe.

All progress is based upon a universal innate desire of every organism to live beyond its means.

All that can be said upon the number and nature of elements is, in my opinion, confined to discussions entirely of a metaphysical nature. The subject only furnishes us with indefinite problems, which may be solved in a thousand different ways, not one of which, in all probability, is consistent with nature. I shall therefore only add upon this subject, that if, by the term elements, we mean to express those simple and indivisible atoms of which matter is composed, it is extremely probable we know nothing at all about them; but, if we apply the term elements, or principles of bodies, to express our idea of the last point which analysis is capable of reaching, we must admit, as elements, all the substances into which we are capable, by any means, to reduce bodies by decomposition.

All the truths of mathematics are linked to each other, and all means of discovering them are equally admissible.

All these delusions of Divination have their root and foundation from Astrology. For whether the lineaments of the body, countenance, or hand be inspected, whether dream or vision be seen, whether marking of entrails or mad inspiration be consulted, there must be a Celestial Figure first erected, by the means of whole indications, together with the conjectures of Signs and Similitudes, they endeavour to find out the truth of what is desired.

All true science must aim at objective truth, and that means that the human observer must never allow himself to get emotionally mixed up with his subject-matter. His concern is to understand the universe, not to improve it. Detachment is obligatory.

America has never been united by blood or birth or soil. We are bound by ideals that move us beyond our backgrounds, lift us above our interests and teach us what it means to be citizens. Every child must be taught these principles. Every citizen must uphold them. And every immigrant, by embracing these ideals, makes our country more, not less, American.

Among innumerable footsteps of divine providence to be found in the works of nature, there is a very remarkable one to be observed in the exact balance that is maintained, between the numbers of men and women; for by this means is provided, that the species never may fail, nor perish, since every male may have its female, and of proportionable age. This equality of males and females is not the effect of chance but divine providence, working for a good end.

Among natural bodies some have, and some have not, life; and by life we mean the faculties of self-nourishment, self-growth and self-decay. Thus every natural body partaking of life may be regarded as an essential existence; … but then it is an existence only in combination. … And since the organism is such a combination, being possessed of life, it cannot be the Vital Principle. Therefore it follows that the Vital Principle most be an essence, as being the form of a natural body, holding life in potentiality; but essence is a reality (entetechie). The Vital Principle is the original reality of a natural body endowed with potential life; this, however, is to be understood only of a body which may be organized. Thus the parts even of plants are organs, but they are organs that are altogether simple; as the leaf which is the covering of the pericarp, the pericarp of the fruit. If, then, there be any general formula for every kind of Vital Principle, it is—tthe primary reality of an organism.

An equation means nothing to me unless it expresses a thought of God.

An individual can’t be judged by his group mean.

An infinity of these tiny animals defoliate our plants, our trees, our fruits... they attack our houses, our fabrics, our furniture, our clothing, our furs ... He who in studying all the different species of insects that are injurious to us, would seek means of preventing them from harming us, would seek to cause them to perish, proposes for his goal important tasks indeed.

An inventor is an opportunist, one who takes occasion by the hand; who, having seen where some want exists, successfully applies the right means to attain the desired end. The means may be largely, or even wholly, something already known, or there may be a certain originality or discovery in the means employed. But in every case the inventor uses the work of others. If I may use a metaphor, I should liken him to the man who essays the conquest of some virgin alp. At the outset he uses the beaten track, and, as he progresses in the ascent, he uses the steps made by those who have preceded him, whenever they lead in the right direction; and it is only after the last footprints have died out that he takes ice-axe in hand and cuts the remaining steps, few or many, that lift him to the crowning height which is his goal.

An inventor is one who can see the applicability of means to supply demand five years before it is obvious to those skilled in the art.

An organized product of nature is that in which all the parts are mutually ends and means.

An unelectrified atom is so elusive that unless more than a million million are present we have no means sufficiently sensitive to detect them, or, to put it another way, unless we had a better test for a man than for an unelectrified molecule, we should be unable to find out that the earth was inhabited. … A billion unelectrified atoms may escape our observation, whereas a dozen or so electrified ones are detected without difficulty.

Analysis and natural philosophy owe their most important discoveries to this fruitful means, which is called induction. Newton was indebted to it for his theorem of the binomial and the principle of universal gravity.

And beyond our galaxy are other galaxies, in the universe all told at least a hundred billion, each containing a hundred billion stars. Do these figures mean anything to you?

And if you want the exact moment in time, it was conceived mentally on 8th March in this year one thousand six hundred and eighteen, but submitted to calculation in an unlucky way, and therefore rejected as false, and finally returning on the 15th of May and adopting a new line of attack, stormed the darkness of my mind. So strong was the support from the combination of my labour of seventeen years on the observations of Brahe and the present study, which conspired together, that at first I believed I was dreaming, and assuming my conclusion among my basic premises. But it is absolutely certain and exact that the proportion between the periodic times of any two planets is precisely the sesquialterate proportion of their mean distances.

And, to prevent mistakes, I must advertize you, that I now mean by elements, as those chymists that speak plainest do by their principles, certain primitive or simple, or perfectly unmingled bodies; which not being made of any other bodies, or of one another, are the ingredients of which all those called perfectly mixt bodies are immediately compounded, and into which they are ultimately resolved: now whether there be any such body to be constantly met with in all, and each, of those that are said to be elemented bodies, is the thing I now question.

Any conception which is definitely and completely determined by means of a finite number of specifications, say by assigning a finite number of elements, is a mathematical conception. Mathematics has for its function to develop the consequences involved in the definition of a group of mathematical conceptions. Interdependence and mutual logical consistency among the members of the group are postulated, otherwise the group would either have to be treated as several distinct groups, or would lie beyond the sphere of mathematics.

Any experiment may be regarded as forming an individual of a 'population' of experiments which might be performed under the same conditions. A series of experiments is a sample drawn from this population.
Now any series of experiments is only of value in so far as it enables us to form a judgment as to the statistical constants of the population to which the experiments belong. In a great number of cases the question finally turns on the value of a mean, either directly, or as the mean difference between the two qualities.
If the number of experiments be very large, we may have precise information as to the value of the mean, but if our sample be small, we have two sources of uncertainty:— (I) owing to the 'error of random sampling' the mean of our series of experiments deviates more or less widely from the mean of the population, and (2) the sample is not sufficiently large to determine what is the law of distribution of individuals.

Archimedes possessed so high a spirit, so profound a soul, and such treasures of highly scientific knowledge, that though these inventions [used to defend Syracuse against the Romans] had now obtained him the renown of more than human sagacity, he yet would not deign to leave behind him any commentary or writing on such subjects; but, repudiating as sordid and ignoble the whole trade of engineering, and every sort of art that lends itself to mere use and profit, he placed his whole affection and ambition in those purer speculations where there can be no reference to the vulgar needs of life; studies, the superiority of which to all others is unquestioned, and in which the only doubt can be whether the beauty and grandeur of the subjects examined, or the precision and cogency of the methods and means of proof, most deserve our admiration.

Archimedes will be remembered when Aeschylus is forgotten, because languages die and mathematical ideas do not. “Immortality” may be a silly word, but probably a mathematician has the best chance of whatever it may mean.

Archimedes [indicates] that there can be no true levelling by means of water, because he holds that water has not a level surface, but is of a spherical form, having its centre at the centre of the earth.

Art and Religion are, then, two roads by which men escape from circumstance to ecstasy. Between aesthetic and religious rapture there is a family alliance. Art and Religion are means to similar states of mind.

Art and science coincide insofar as both aim to improve the lives of men and women. The latter normally concerns itself with profit, the former with pleasure. In the coming age, art will fashion our entertainment out of new means of productivity in ways that will simultaneously enhance our profit and maximize our pleasure.

Art arises in those strange complexities of action that are called human beings. It is a kind of human behavior. As such it is not magic, except as human beings are magical. Nor is it concerned in absolutes, eternities, “forms,” beyond those that may reside in the context of the human being and be subject to his vicissitudes. Art is not an inner state of consciousness, whatever that may mean. Neither is it essentially a supreme form of communication. Art is human behavior, and its values are contained in human behavior.

As a progressive discipline [biochemistry] belongs to the present century. From the experimental physiologists of the last century it obtained a charter, and, from a few pioneers of its own, a promise of success; but for the furtherance of its essential aim that century left it but a small inheritance of facts and methods. By its essential or ultimate aim I myself mean an adequate and acceptable description of molecular dynamics in living cells and tissues.

As every circumstance relating to so capital a discovery as this (the greatest, perhaps, that has been made in the whole compass of philosophy, since the time of Sir Isaac Newton) cannot but give pleasure to all my readers, I shall endeavour to gratify them with the communication of a few particulars which I have from the best authority. The Doctor [Benjamin Franklin], after having published his method of verifying his hypothesis concerning the sameness of electricity with the matter lightning, was waiting for the erection of a spire in Philadelphia to carry his views into execution; not imagining that a pointed rod, of a moderate height, could answer the purpose; when it occurred to him, that, by means of a common kite, he could have a readier and better access to the regions of thunder than by any spire whatever. Preparing, therefore, a large silk handkerchief, and two cross sticks, of a proper length, on which to extend it, he took the opportunity of the first approaching thunder storm to take a walk into a field, in which there was a shed convenient for his purpose. But dreading the ridicule which too commonly attends unsuccessful attempts in science, he communicated his intended experiment to no body but his son, who assisted him in raising the kite.
The kite being raised, a considerable time elapsed before there was any appearance of its being electrified. One very promising cloud passed over it without any effect; when, at length, just as he was beginning to despair of his contrivance, he observed some loose threads of the hempen string to stand erect, and to avoid one another, just as if they had been suspended on a common conductor. Struck with this promising appearance, he inmmediately presented his knuckle to the key, and (let the reader judge of the exquisite pleasure he must have felt at that moment) the discovery was complete. He perceived a very evident electric spark. Others succeeded, even before the string was wet, so as to put the matter past all dispute, and when the rain had wetted the string, he collected electric fire very copiously. This happened in June 1752, a month after the electricians in France had verified the same theory, but before he had heard of any thing that they had done.

As for “Don’t be evil,” we have tried to define precisely what it means to be a force for good—always do the right, ethical thing. Ultimately, “Don’t be evil” seems the easiest way to summarize it.

As ideas are preserved and communicated by means of words, it necessarily follows that we cannot improve the language of any science, without at the same time improving the science itself; neither can we, on the other hand, improve a science without improving the language or nomenclature which belongs to it.

As science is more and more subject to grave misuse as well as to use for human benefit it has also become the scientist's responsibility to become aware of the social relations and applications of his subject, and to exert his influence in such a direction as will result in the best applications of the findings in his own and related fields. Thus he must help in educating the public, in the broad sense, and this means first educating himself, not only in science but in regard to the great issues confronting mankind today.

As there is not in human observation proper means for measuring the waste of land upon the globe, it is hence inferred, that we cannot estimate the duration of what we see at present, nor calculate the period at which it had begun; so that, with respect to human observation, this world has neither a beginning nor an end.

As was predicted at the beginning of the Human Genome Project, getting the sequence will be the easy part as only technical issues are involved. The hard part will be finding out what it means, because this poses intellectual problems of how to understand the participation of the genes in the functions of living cells.

At last gleams of light have come, and I am almost convinced (quite contrary to opinion I started with) that species are not (it is like confessing a murder) immutable. Heaven forfend me from Lamarck nonsense of a “tendency to progression”, “adaptations from the slow willing of animals”, &c! But the conclusions I am led to are not widely different from his; though the means of change are wholly so. I think I have found out (here’s presumption!) the simple way by which species become exquisitely adapted to various ends.

At the present time there exist problems beyond our ability to solve, not because of theoretical difficulties, but because of insufficient means of mechanical computation.

Basic research at universities comes in two varieties: research that requires big bucks and research that requires small bucks. Big bucks research is much like government research and in fact usually is government research but done for the government under contract. Like other government research, big bucks academic research is done to understand the nature and structure of the universe or to understand life, which really means that it is either for blowing up the world or extending life, whichever comes first. Again, that's the government's motivation. The universities' motivation for conducting big bucks research is to bring money in to support professors and graduate students and to wax the floors of ivy-covered buildings. While we think they are busy teaching and learning, these folks are mainly doing big bucks basic research for a living, all the while priding themselves on their terrific summer vacations and lack of a dress code.
Smalls bucks research is the sort of thing that requires paper and pencil, and maybe a blackboard, and is aimed primarily at increasing knowledge in areas of study that don't usually attract big bucks - that is, areas that don't extend life or end it, or both. History, political science, and romance languages are typically small bucks areas of basic research. The real purpose of small bucks research to the universities is to provide a means of deciding, by the quality of their small bucks research, which professors in these areas should get tenure.

Because words pass away as soon as they strike upon the air, and last no longer than their sound, men have by means of letters formed signs of words. Thus the sounds of the voice are made visible to the eye, not of course as sounds, but by means of certain signs.

Before an experiment can be performed, it must be planned—the question to nature must be formulated before being posed. Before the result of a measurement can be used, it must be interpreted—nature's answer must be understood properly. These two tasks are those of the theorist, who finds himself always more and more dependent on the tools of abstract mathematics. Of course, this does not mean that the experimenter does not also engage in theoretical deliberations. The foremost classical example of a major achievement produced by such a division of labor is the creation of spectrum analysis by the joint efforts of Robert Bunsen, the experimenter, and Gustav Kirchoff, the theorist. Since then, spectrum analysis has been continually developing and bearing ever richer fruit.

Before his [Sir Astley Cooper’s] time, operations were too often frightful alternatives or hazardous compromises; and they were not seldom considered rather as the resource of despair than as a means of remedy; he always made them follow, as it were, in the natural course of treatment; he gave them a scientific character; and he moreover, succeeded, in a great degree, in divesting them of their terrors, by performing them unostentatiously, simply, confidently, and cheerfully, and thereby inspiring the patient with hope of relief, where previously resignation under misfortune had too often been all that could be expected from the sufferer.

Behavioral avoidance, not physiological adaptations, is an organism’s primary response to an environmental challenge. This point is elementary, but it is by no means trivial.

Besides electrical engineering theory of the transmission of messages, there is a larger field [cybernetics] which includes not only the study of language but the study of messages as a means of controlling machinery and society, the development of computing machines and other such automata, certain reflections upon psychology and the nervous system, and a tentative new theory of scientific method.

Biologists have long attempted by chemical means to induce in higher organisms predictable and specific changes which thereafter could be transmitted in series as hereditary characters. Among microorganisms the most striking example of inheritable and specific alterations in cell structure and function that can be experimentally induced and are reproducible under well defined and adequately controlled conditions is the transformation of specific types of Pneumococcus.

Biology is the only science in which multiplication means the same thing as division.

Broadly speaking, we are in the middle of a race between human skill as a means and human folly as an end.

But as my conclusions have lately been much misrepresented, and it has been stated that I attribute the modification of species exclusively to natural selection, I may be permitted to remark that in the first edition of this work, and subsequently, I placed in a most conspicuous position—namely, at the close of the Introduction—the following words: “I am convinced that natural selection has been the main but not the exclusive means of modification.” This has been of no avail. Great is the power of steady misrepresentation; but the history of science shows that fortunately this power does not long endure.

But I do not feel obliged to believe that that same God who has endowed us with senses, reason, and intellect has intended to forgo their use and by some other means to give us knowledge which we can attain by them.

But I shall certainly admit a system as empirical or scientific only if it is capable of being tested by experience. These considerations suggest that not the verifiability but the falsifiability of a system is to be taken as a criterion of demarcation. In other words: I shall not require of a scientific system that it shall be capable of being singled out, once and for all, in a positive sense; but I shall require that its logical form shall be such that it can be singled out, by means of empirical tests, in a negative sense: it must be possible for an empirical scientific system to be refuted by experience. (1959)

But medicine has long had all its means to hand, and has discovered both a principle and a method, through which the discoveries made during a long period are many and excellent, while full discovery will be made, if the inquirer be competent, conduct his researches with knowledge of the discoveries already made, and make them his starting-point. But anyone who, casting aside and rejecting all these means, attempts to conduct research in any other way or after another fashion, and asserts that he has found out anything, is and has been victim of deception.

But regular biology, as an "ology," has to be "scientific," and this means in practice that it has to be made dull.... Everything has to be expressed in utterly impersonal terms.

But Truth is that besides which there is nothing: nothing to modify it, nothing to question it, nothing to form an exception: the all-inclusive, the complete — By Truth, I mean the Universal.

But we shall not satisfy ourselves simply with improving steam and explosive engines or inventing new batteries; we have something much better to work for, a greater task to fulfill. We have to evolve means for obtaining energy from stores which are forever inexhaustible, to perfect methods which do not imply consumption and waste of any material whatever.

But, you might say, “none of this shakes my belief that 2 and 2 are 4.” You are quite right, except in marginal cases—and it is only in marginal cases that you are doubtful whether a certain animal is a dog or a certain length is less than a meter. Two must be two of something, and the proposition “2 and 2 are 4” is useless unless it can be applied. Two dogs and two dogs are certainly four dogs, but cases arise in which you are doubtful whether two of them are dogs. “Well, at any rate there are four animals,” you may say. But there are microorganisms concerning which it is doubtful whether they are animals or plants. “Well, then living organisms,” you say. But there are things of which it is doubtful whether they are living organisms or not. You will be driven into saying: “Two entities and two entities are four entities.” When you have told me what you mean by “entity,” we will resume the argument.

By a generative grammar I mean simply a system of rules that in some explicit and well-defined way assigns structural descriptions to sentences. Obviously, every speaker of a language has mastered and internalized a generative grammar that expresses his knowledge of his language. This is not to say that he is aware of the rules of the grammar or even that he can become aware of them, or that his statements about his intuitive knowledge of the language are necessarily accurate.

By destroying the biological character of phenomena, the use of averages in physiology and medicine usually gives only apparent accuracy to the results. From our point of view, we may distinguish between several kinds of averages: physical averages, chemical averages and physiological and pathological averages. If, for instance, we observe the number of pulsations and the degree of blood pressure by means of the oscillations of a manometer throughout one day, and if we take the average of all our figures to get the true or average blood pressure and to learn the true or average number of pulsations, we shall simply have wrong numbers. In fact, the pulse decreases in number and intensity when we are fasting and increases during digestion or under different influences of movement and rest; all the biological characteristics of the phenomenon disappear in the average. Chemical averages are also often used. If we collect a man's urine during twenty-four hours and mix all this urine to analyze the average, we get an analysis of a urine which simply does not exist; for urine, when fasting, is different from urine during digestion. A startling instance of this kind was invented by a physiologist who took urine from a railroad station urinal where people of all nations passed, and who believed he could thus present an analysis of average European urine! Aside from physical and chemical, there are physiological averages, or what we might call average descriptions of phenomena, which are even more false. Let me assume that a physician collects a great many individual observations of a disease and that he makes an average description of symptoms observed in the individual cases; he will thus have a description that will never be matched in nature. So in physiology, we must never make average descriptions of experiments, because the true relations of phenomena disappear in the average; when dealing with complex and variable experiments, we must study their various circumstances, and then present our most perfect experiment as a type, which, however, still stands for true facts. In the cases just considered, averages must therefore be rejected, because they confuse, while aiming to unify, and distort while aiming to simplify. Averages are applicable only to reducing very slightly varying numerical data about clearly defined and absolutely simple cases.

By means of the Mummy, mankind, it is said,
Attests to the gods its respect for the dead.
We plunder his tomb, be he sinner or saint,
Distill him for physic and grind him for paint,
Exhibit for money his poor, shrunken frame,
And with levity flock to the scene of the shame.
O, tell me, ye gods, for the use of my rhyme:
For respecting the dead what’s the limit of time?

By research in pure science I mean research made without any idea of application to industrial matters but solely with the view of extending our knowledge of the Laws of Nature. I will give just one example of the ‘utility’ of this kind of research, one that has been brought into great prominence by the War—I mean the use of X-rays in surgery. Now, not to speak of what is beyond money value, the saving of pain, or, it may be, the life of the wounded, and of bitter grief to those who loved them, the benefit which the state has derived from the restoration of so many to life and limb, able to render services which would otherwise have been lost, is almost incalculable. Now, how was this method discovered? It was not the result of a research in applied science starting to find an improved method of locating bullet wounds. This might have led to improved probes, but we cannot imagine it leading to the discovery of X-rays. No, this method is due to an investigation in pure science, made with the object of discovering what is the nature of Electricity. The experiments which led to this discovery seemed to be as remote from ‘humanistic interest’ —to use a much misappropriated word—as anything that could well be imagined. The apparatus consisted of glass vessels from which the last drops of air had been sucked, and which emitted a weird greenish light when stimulated by formidable looking instruments called induction coils. Near by, perhaps, were great coils of wire and iron built up into electro-magnets. I know well the impression it made on the average spectator, for I have been occupied in experiments of this kind nearly all my life, notwithstanding the advice, given in perfect good faith, by non-scientific visitors to the laboratory, to put that aside and spend my time on something useful.

By the classification of any series of objects, is meant the actual or ideal arrangement together of those which are like and the separation of those which are unlike ; the purpose of this arrangement being to facilitate the operations of the mind in clearly conceiving and retaining in the memory the characters of the objects in question.‎

Can any thoughtful person admit for a moment that, in a society so constituted that these overwhelming contrasts of luxury and privation are looked upon as necessities, and are treated by the Legislature as matters with which it has practically nothing do, there is the smallest probability that we can deal successfully with such tremendous social problems as those which involve the marriage tie and the family relation as a means of promoting the physical and moral advancement of the race? What a mockery to still further whiten the sepulchre of society, in which is hidden ‘all manner of corruption,’ with schemes for the moral and physical advancement of the race!

Careful and correct use of language is a powerful aid to straight thinking, for putting into words precisely what we mean necessitates getting our own minds quite clear on what we mean.

Cayley was singularly learned in the work of other men, and catholic in his range of knowledge. Yet he did not read a memoir completely through: his custom was to read only so much as would enable him to grasp the meaning of the symbols and understand its scope. The main result would then become to him a subject of investigation: he would establish it (or test it) by algebraic analysis and, not infrequently, develop it so to obtain other results. This faculty of grasping and testing rapidly the work of others, together with his great knowledge, made him an invaluable referee; his services in this capacity were used through a long series of years by a number of societies to which he was almost in the position of standing mathematical advisor.

Chemistry is one of those branches of human knowledge which has built itself upon methods and instruments by which truth can presumably be determined. It has survived and grown because all its precepts and principles can be re-tested at any time and anywhere. So long as it remained the mysterious alchemy by which a few devotees, by devious and dubious means, presumed to change baser metals into gold, it did not flourish, but when it dealt with the fact that 56 g. of fine iron, when heated with 32 g. of flowers of sulfur, generated extra heat and gave exactly 88 g. of an entirely new substance, then additional steps could be taken by anyone. Scientific research in chemistry, since the birth of the balance and the thermometer, has been a steady growth of test and observation. It has disclosed a finite number of elementary reagents composing an infinite universe, and it is devoted to their inter-reaction for the benefit of mankind.

Chief Seattle, of the Indians that inhabited the Seattle area, wrote a wonderful paper that has to do with putting oneself in tune with the universe. He said, “Why should I lament the disappearance of my people! All things end, and the white man will find this out also.” And this goes for the universe. One can be at peace with that. This doesn’t mean that one shouldn’t participate in efforts to correct the situation. But underlying the effort to change must be an “at peace.” To win a dog sled race is great. To lose is okay too.

Combining in our survey then, the whole range of deposits from the most recent to the most ancient group, how striking a succession do they present:– so various yet so uniform–so vast yet so connected. In thus tracing back to the most remote periods in the physical history of our continents, one system of operations, as the means by which many complex formations have been successively produced, the mind becomes impressed with the singleness of nature's laws; and in this respect, at least, geology is hardly inferior in simplicity to astronomy.

Concerning the gods, I have no means of knowing either that they exist or that they do not exist, nor what sort of form they may have; there are many reasons why knowledge on this subject is not possible, owing to the lack of evidence and the shortness of human life.

Conservation means development as much as it does protection. I recognize the right and duty of this generation to develop and use the natural resources of our land; but I do not recognize the right to waste them, or to rob, by wasteful use, the generations that come after us.

Conservation means the wise use of the earth and its resources for the lasting good of men.

Copernicus, the most learned man whom we are able to name other than Atlas and Ptolemy, even though he taught in a most learned manner the demonstrations and causes of motion based on observation, nevertheless fled from the job of constructing tables, so that if anyone computes from his tables, the computation is not even in agreement with his observations on which the foundation of the work rests. Therefore first I have compared the observations of Copernicus with those of Ptolemy and others as to which are the most accurate, but besides the bare observations, I have taken from Copernicus nothing other than traces of demonstrations. As for the tables of mean motion, and of prosthaphaereses and all the rest, I have constructed these anew, following absolutely no other reasoning than that which I have judged to be of maximum harmony.