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Who said: “As far as the laws of mathematics refer to reality, they are not certain; and as far as they are certain, they do not refer to reality.”
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Substance Quotes (248 quotes)

Bei solchen chemischen Untersuchungen, die man zersetzende oder zergliedernde nennt, kommt es zunächst darauf an, zu ermitteln, mit welchen Stoffen man es zu thun hat, oder um chemisch zu reden, welche Stoffe in einem bestimmten Gemenge oder Gemisch enthalten sind. Hierzu bedient man sich sogenannter gegenwirkender Mittel, d. h. Stoffe, die bestimmte Eigenschaften und Eigenthümlichkeiten besitzen und die man aus Ueberlieferung oder eigner Erfahrung genau kennt, so daß die Veränderungen, welche sie bewirken oder erleiden, gleichsam die Sprache sind, mit der sie reden und dadurch dem Forscher anzeigen, daß der und der bestimmte Stoff in der fraglichen Mischung enthalten sei.
In the case of chemical investigations known as decompositions or analyses, it is first important to determine exactly what ingredients you are dealing with, or chemically speaking, what substances are contained in a given mixture or composite. For this purpose we use reagents, i.e., substances that possess certain properties and characteristics, which we well know from references or personal experience, such that the changes which they bring about or undergo, so to say the language that they speak thereby inform the researcher that this or that specific substance is present in the mixture in question.
From Zur Farben-Chemie Musterbilder für Freunde des Schönen und zum Gebrauch für Zeichner, Maler, Verzierer und Zeugdrucker [On Colour Chemistry...] (1850), Introduction. Translation tweaked by Webmaster from version in Herbert and W. Roesky and Klaud Möckel, translated from the original German by T.N. Mitchell and W.E. Russey, Chemical Curiosities: Spectacular Experiments and Inspired Quotes (1996), 1.
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Dass die bis jetzt unzerlegten chemischen Elemente absolut unzerlegbare Stoffe seien, ist gegenwärtig mindestens sehr unwahrscheinlich. Vielmehr scheint es, dass die Atome der Elemente nicht die letzten, sondern nur die näheren Bestandtheile der Molekeln sowohl der Elemente wie der Verbindungen bilden, die Molekeln oder Molecule als Massentheile erster, die Atome als solche zweiter Ordnung anzusehen sind, die ihrerseits wiederum aus Massentheilchen einer dritten höheren Ordnung bestehen werden.
That the as yet undivided chemical elements are absolutely irreducible substances, is currently at least very unlikely. Rather it seems, that the atoms of elements are not the final, but only the immediate constituents of the molecules of both the elements and the compounds—the Molekeln or molecule as foremost division of matter, the atoms being considered as second order, in turn consisting of matter particles of a third higher order.
[Speculating in 1870, on the existence of subatomic particles, in opening remark of the paper by which he became established as co-discoverer of the Periodic Law.]
'Die Natur der chemischen Elemente als Function ihrer Atomgewichte' ('The Nature of the Chemical Elements as a Function of their Atomic Weight'), Annalen der Chemie (1870), supp. b, 354. Original German paper reprinted in Lothar Meyer and Dmitry Ivanovich Mendeleyev, Das natürliche System der chemischen Elemente: Abhandlungen (1895), 9. Translation by Webmaster, with punctuation faithful to the original, except a comma was changed to a dash to improve readability.
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La chaleur pénètre, comme la gravité, toutes les substances de l’univers, ses rayons occupent toutes les parties de l’espace. Le but de notre ouvrage est d’exposer les lois mathématiques que suit cet élément. Cette théorie formera désormais une des branches les plus importantes de la physique générale.
Heat, like gravity, penetrates every substance of the universe, its rays occupy all parts of space. The object of our work is to set forth the mathematical laws which this element obeys. The theory of heat will hereafter form one of the most important branches of general physics.
From 'Discours Préliminaire' to Théorie Analytique de la Chaleur (1822), i, translated by Alexander Freeman in The Analytical Theory of Heat (1878), 1.
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Wenn sich für ein neues Fossil kein, auf eigenthümliche Eigenschaften desselben hinweisender, Name auffinden lassen Will; als in welchem Falle ich mich bei dem gegenwärtigen zu befinden gestehe; so halte ich es für besser, eine solche Benennung auszuwählen, die an sich gar nichts sagt, und folglich auch zu keinen unrichtigen Begriffen Anlass geben kann. Diesem zufolge will ich den Namen für die gegenwärtige metallische Substanz, gleichergestalt wie bei dem Uranium geschehen, aus der Mythologie, und zwar von den Ursöhnen der Erde, den Titanen, entlehnen, und benenne also dieses neue Metallgeschlecht: Titanium.
Wherefore no name can be found for a new fossil [element] which indicates its peculiar and characteristic properties (in which position I find myself at present), I think it is best to choose such a denomination as means nothing of itself and thus can give no rise to any erroneous ideas. In consequence of this, as I did in the case of Uranium, I shall borrow the name for this metallic substance from mythology, and in particular from the Titans, the first sons of the earth. I therefore call this metallic genus TITANIUM.
Martin Heinrich Klaproth. Original German edition, Beiträge Zur Chemischen Kenntniss Der Mineralkörper (1795), Vol. 1 , 244. English edition, translator not named, Analytical Essays Towards Promoting the Chemical Knowledge of Mineral Substances (1801), Vol. 1, 210. Klaproth's use of the term fossil associates his knowledge of the metal as from ore samples dug out of a mine.
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[Pechblende] einer eigenthümlichen, selbstständigen metallischen Substanz bestehe. Es fallen folglich auch deren bisherige Benennungen, als: Ресhblende Eisenpecherz, hinweg, welche nun durch einen neuen ausschliessend bezeichnenden Namen zu ersetzen sind. Ich habe dazu den Namen: Uranerz (Uranium) erwählt; zu einigem Andenken, dass die chemische Ausfindung dieses neuen Metallkörpers in die Epoche der astronomischen. Entdeckung des Planeten Uranus gefallen sei.
[Pitchblende] consists of a peculiar, distinct, metallic substance. Therefore its former denominations, pitch-blende, pitch-iron-ore, &c. are no longer applicable, and must be supplied by another more appropriate name.—I have chosen that of uranite, (Uranium), as a kind of memorial, that the chemical discovery of this new metal happened in the period of the astronomical discovery of the new planet Uranus.
In original German edition, Beiträge Zur Chemischen Kenntniss Der Mineralkörper (1797), Vol. 2, 215. English edition, translator not named, Analytical Essays Towards Promoting the Chemical Knowledge of Mineral Substances (1801), 491. The new planet was discovered on 13 Mar 1781 by William Herschel, who originally named it Georgium Sidus (George's Star) to honour King George III.
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A catalyst is a substance which alters the velocity of a chemical reaction without appearing in the final products.
'Über Katalyse', Zeitschrift für Physikalische Chemie (1901), 7, 995-1004 as quoted in J. R. Partington, A History of Chemistry, Vol. 4 (1901), 599-600.
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A cell of a higher organism contains a thousand different substances, arranged in a complex system. This great organized system was not discovered by chemical or physical methods; they are inadequate to its refinement and delicacy and complexity.
'The Cell in Relation to its Environment', Journal of the Maryland Academy of Sciences (1931), 2, 25.
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A chemical name should not be a phrase, it ought not to require circumlocutions to become definite; it should not be of the type “Glauber’s salt”, which conveys nothing about the composition of the substance; it should recall the constituents of a compound; it should be non-committal if nothing is known about the substance; the names should preferably be coined from Latin or Greek, so that their meaning can be more widely and easily understood; the form of the words should be such that they fit easily into the language into which they are to be incorporated.
(1782) As quoted in Archibald Clow, Chemical Revolution: A Contribution to Social Technology (1952, 1992), 618.
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A drop from the nose of Fleming, who had a cold, fell onto an agar plate where large yellow colonies of a contaminant had grown, and lysosyme was discovered. He made this important discovery because when he saw that the colonies of the contaminant were fading, his mind went straight to the right cause of the phenomenon he was observing—that the drop from his nose contained a lytic substance. And also immediately, he thought that this substance might be present in many secretions and tissues of the body. And he found this was so—the substance was in tears, saliva, leucocytes, skin, fingernails, mother's milk—thus very widely distributed in amounts and also in plants.
Personal recollections of Alexander Fleming by Lady Amelia Fleming. Quoted in Molecular Cloning (2001), Vol. 1, 153.
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A drug is a substance which, if injected into a rabbit, produces a paper.
Quoted in Albert Szent-Gyorgyi, 'Some Reminiscences of My Life as a Scientist', International Journal of Quantum Biology Symposium (1976), 3, 7.
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A man of about fifty-four years of age, had begun, five or six months before, to be somewhat emaciated in his whole body...a troublesome vomiting came on, of a fluid which resembl’d water, tinctur’d with soot.... Death took place.... In the stomach...was an ulcerated cancerous tumour.... Betwixt the stomach and the spleen were two glandular bodies, of the bigness of a bean, and in their colour, and substance, not much unlike that tumour which I have describ’d in the stomach.
About stomach cancer. In De Sedibus Causis Morborum (1761). Translated by Benjamin Alexander in The Seats and Causes of Diseases (1960), 43
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A schism has taken place among the chemists. A particular set of them in France have undertaken to remodel all the terms of the science, and to give every substance a new name, the composition, and especially the termination of which, shall define the relation in which it stands to other substances of the same family, But the science seems too much in its infancy as yet, for this reformation; because in fact, the reformation of this year must be reformed again the next year, and so on, changing the names of substances as often as new experiments develop properties in them undiscovered before. The new nomenclature has, accordingly, been already proved to need numerous and important reformations. ... It is espoused by the minority here, and by the very few, indeed, of the foreign chemists. It is particularly rejected in England.
Letter to Dr. Willard (Paris, 1788). In Thomas Jefferson and John P. Foley (ed.), The Jeffersonian Cyclopedia (1900), 135. From H.A. Washington, The Writings of Thomas Jefferson (1853-54). Vol 3, 15.
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A single kind of red cell is supposed to have an enormous number of different substances on it, and in the same way there are substances in the serum to react with many different animal cells. In addition, the substances which match each kind of cell are different in each kind of serum. The number of hypothetical different substances postulated makes this conception so uneconomical that the question must be asked whether it is the only one possible. ... We ourselves hold that another, simpler, explanation is possible.
Landsteiner and Adriano Sturli, 'Hamagglutinine normaler Sera', Wiener klinische Wochenschrift (1902), 15, 38-40. Trans. Pauline M. H. Mazumdar.
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A substance that makes you ill if you don’t eat it.
[His definition of a vitamin.]
Attributed.
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About eight days ago I discovered that sulfur in burning, far from losing weight, on the contrary, gains it; it is the same with phosphorus; this increase of weight arises from a prodigious quantity of air that is fixed during combustion and combines with the vapors. This discovery, which I have established by experiments, that I regard as decisive, has led me to think that what is observed in the combustion of sulfur and phosphorus may well take place in the case of all substances that gain in weight by combustion and calcination; and I am persuaded that the increase in weight of metallic calxes is due to the same cause... This discovery seems to me one of the most interesting that has been made since Stahl and since it is difficult not to disclose something inadvertently in conversation with friends that could lead to the truth I have thought it necessary to make the present deposit to the Secretary of the Academy to await the time I make my experiments public.
Sealed note deposited with the Secretary of the French Academy 1 Nov 1772. Oeuvres de Lavoisier, Correspondance, Fasc. II. 1770-75 (1957), 389-90. Adapted from translation by A. N. Meldrum, The Eighteenth-Century Revolution in Science (1930), 3.
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According to the older view, for every single effect of a serum, there was a separate substance, or at least a particular chemical group... A normal serum contained as many different haemagglutinins as it agglutinated different cells. The situation was undoubtedly made much simpler if, to use the Ehrlich terminology... the separate haptophore groups can combine with an extremely large number of receptors in stepwise differing quantities as a stain does with different animal tissues, though not always with the same intensity. A normal serum would therefore visibly affect such a large number of different blood cells... not because it contained countless special substances, but because of the colloids of the serum, and therefore of the agglutinins by reason of their chemical constitution and the electrochemical properties resulting from it. That this manner of representation is a considerable simplification is clear; it also opens the way to direct experimental testing by the methods of structural chemistry.
'Die Theorien der Antikorperbildung ... ', Wiener klinische Wöchenschrift (1909), 22, 1623-1631. Trans. Pauline M. H. Mazumdar.
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Acid Salts have the Power of Destroying the Blewness of the Infusion of our Wood [lignum nephreticum], and those Liquors indiscriminatly that abound with Sulphurous Salts, (under which I comprehend the Urinous and Volatile Salts of Animal Substances, and the Alcalisate or fixed Salts that are made by Incineration) have the virtue of Restoring it.
Experiments and Considerations Touching Colours (1664), 212.
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After death, life reappears in a different form and with different laws. It is inscribed in the laws of the permanence of life on the surface of the earth and everything that has been a plant and an animal will be destroyed and transformed into a gaseous, volatile and mineral substance.
Quoted in Patrice Debré, Louis Pasteur, trans. Elborg Forster (1994), 110.
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AIR, n. A nutritious substance supplied by a bountiful Providence for the fattening of the poor.
The Collected Works of Ambrose Bierce (1911), Vol. 7, The Devil's Dictionary,  21.
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All substances are poisonous, there is none that is not a poison; the right dose differentiates a poison from a remedy.
In Robert Allan Weinberg, The Biology of Cancer (2006), 725.
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All that can be said upon the number and nature of elements is, in my opinion, confined to discussions entirely of a metaphysical nature. The subject only furnishes us with indefinite problems, which may be solved in a thousand different ways, not one of which, in all probability, is consistent with nature. I shall therefore only add upon this subject, that if, by the term elements, we mean to express those simple and indivisible atoms of which matter is composed, it is extremely probable we know nothing at all about them; but, if we apply the term elements, or principles of bodies, to express our idea of the last point which analysis is capable of reaching, we must admit, as elements, all the substances into which we are capable, by any means, to reduce bodies by decomposition.
Elements of Chemistry (1790), trans. R. Kerr, Preface, xxiv.
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All the properties that we designate as activity of the soul, are only the functions of the cerebral substance, and to express ourselves in a coarser way, thought is just about to the brain what bile is to the liver and urine to the kidney. It is absurd to admit an independent soul who uses the cerebellum as an instrument with which he would work as he pleases.
Carl Vogt
As quoted in William Vogt, La Vie d'un Homme, Carl Vogt (1896), 48. Translated by Webmaster, from the original French, “Toutes les propriétés que nous designons sous le nom d’activité de l’âme, ne sont que les fonctions de la substance cérébrale, et pour nous exprimer d’ une façon plus grossière, la pensée est à peu près au cerveau ce que la bile est au foie et l’urine au rein. Il est absurde d’ admettre une âme indépendante qui se serve du cervelet comme d’un instrument avec lequelle travaillerait comme il lui plait.”
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All truth is a shadow except the last—yet every Truth is true in its kind. It is substance in its own place, though it be but a shadow in another place, (for it is but a shadow from an intenser substance;) and the shadow is a true shadow, as the substance is a true substance.
The Life of a Christian (1653), first page (unnumbered). In Elizabeth Waterhouse, et al., A Little Book of Life and Death (1902), 145.
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Ammonia is furnished from all animal substances by decomposition. The horns of cattle, especially those of deer, yield it in abundance, and it is from this circumstance that a solution of ammonia in water has been termed hartshorn.
From 'Artist and Mechanic', The artist & Tradesman’s Guide: embracing some leading facts & principles of science, and a variety of matter adapted to the wants of the artist, mechanic, manufacturer, and mercantile community (1827), 14.
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An event experienced is an event perceived, digested, and assimilated into the substance of our being, and the ratio between the number of cases seen and the number of cases assimilated is the measure of experience.
Address, opening of 1932-3 session of U.C.H. Medical School (4 Oct 1932), 'Art and Science in medicine', The Collected Papers of Wilfred Trotter, FRS (1941), 98.
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An example of such emergent phenomena is the origin of life from non-living chemical compounds in the oldest, lifeless oceans of the earth. Here, aided by the radiation energy received from the sun, countless chemical materials were synthesized and accumulated in such a way that they constituted, as it were, a primeval “soup.” In this primeval soup, by infinite variations of lifeless growth and decay of substances during some billions of years, the way of life was ultimately reached, with its metabolism characterized by selective assimilation and dissimilation as end stations of a sluiced and canalized flow of free chemical energy.
In 'The Scientific Character of Geology', The Journal of Geology (Jul 1961), 69, No. 4, 458.
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And by the influence of heat, light, and electrical powers, there is a constant series of changes [in animal and vegetal substances]; matter assumes new forms, the destruction of one order of beings tends to the conservation of another, solution and consolidation, decay and renovation, are connected, and whilst the parts of the system, continue in a state of fluctuation and change, the order and harmony of the whole remain unalterable.
The Elements of Agricultural Chemistry (1813), in J. Davy (ed.) The Collected Works of Sir Humphry Davy(1839-40), Vol 7, 182.
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Anyone of common mental and physical health can practice scientific research. … Anyone can try by patient experiment what happens if this or that substance be mixed in this or that proportion with some other under this or that condition. Anyone can vary the experiment in any number of ways. He that hits in this fashion on something novel and of use will have fame. … The fame will be the product of luck and industry. It will not be the product of special talent.
In Essays of a Catholic Layman in England (1931).
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Architects who have aimed at acquiring manual skill without scholarship have never been able to reach a position of authority to correspond to their pains, while those who relied only upon theories and scholarship were obviously hunting the shadow, not the substance. But those who have a thorough knowledge of both, like men armed at all points, have the sooner attained their object and carried authority with them.
Vitruvius
In De Architectura, Book 1, Chap 1, Sec. 2. As translated in Morris Hicky Morgan (trans.), Vitruvius: The Ten Books on Architecture (1914), 3.
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As a scientist Miss [Rosalind] Franklin was distinguished by extreme clarity and perfection in everything she undertook. Her photographs are among the most beautiful X-ray photographs of any substance ever taken.
In his Obituary for Rosalind Franklin, Nature, 1958, 182, 154. As given in Andrew Brown, J.D. Bernal: The Sage of Science (2005), 359.
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As I am writing, another illustration of ye generation of hills proposed above comes into my mind. Milk is as uniform a liquor as ye chaos was. If beer be poured into it & ye mixture let stand till it be dry, the surface of ye curdled substance will appear as rugged & mountanous as the Earth in any place.
Letter to Thomas Burnet (Jan 1680/1. In H. W. Turnbull (ed.), The Correspondence of Isaac Newton, 1676-1687 (1960), Vol. 2, 334.
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As I have already mentioned, wherever cells are formed, this tough fluid precedes the first solid structures that indicate the presence of future cells. Moreover, we must assume that this substance furnishes the material for the formation of the nucleus and of the primitive sac, not only because these structures are closely apposed to it, but also because,they react to iodine in the same way. We must assume also that the organization of this substance is the process that inaugurates the formation of new cells. It therefore seems justifiable for me to propose a name that refers to its physiological function: I propose the word protoplasma.
H. Mohl, Botanisch Zeitung (1846), 4, col. 73, trans. Henry Harris, The Birth of the Cell (1999), 75.
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Bearing in mind that it is from the vitality of the atmospheric particles that all the mischief arises, it appears that all that is requisite is to dress the wound with some material capable of killing these septic germs, provided that any substance can be found reliable for this purpose, yet not too potent as a caustic. In the course of the year 1864 I was much struck with an account of the remarkable effects produced by carbolic acid upon the sewage of the town of Carlisle, the admixture of a very small proportion not only preventing all odour from the lands irrigated with the refuse material, but, as it was stated, destroying the entozoa which usually infest cattle fed upon such pastures.
'On a New Method of Treating Compound Fracture, Abscesses, etc: With Observations on the Conditions of Supperation', Part 1, The Lancet (1867), 327.
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Because of the way it came into existence, the solar system has only one-way traffic—like Piccadilly Circus. … If we want to make a model to scale, we must take a very tiny object, such as a pea, to represent the sun. On the same scale the nine planets will be small seeds, grains of sand and specks of dust. Even so, Piccadilly Circus is only just big enough to contain the orbit of Pluto. … The whole of Piccadilly Circus was needed to represent the space of the solar system, but a child can carry the whole substance of the model in its hand. All the rest is empty space.
In The Stars in Their Courses (1931, 1954), 49-50 & 89.
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Before you generalize, formalize, and axiomatize there must be mathematical substance.
In Eberhard Zeidler, Applied Functional Analysis: main principles and their applications (1995), 282.
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Briefly, in the act of composition, as an instrument there intervenes and is most potent, fire, flaming, fervid, hot; but in the very substance of the compound there intervenes, as an ingredient, as it is commonly called, as a material principle and as a constituent of the whole compound the material and principle of fire, not fire itself. This I was the first to call phlogiston.
Specimen Beccherianum (1703). Trans. J. R. Partington, A History of Chemistry (1961), Vol. 2, 668.
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Built up of carbon, hydrogen, oxygen, nitrogen, together with traces of a few other elements, yet of a complexity of structure that has hitherto resisted all attempts at complete analysis, protoplasm is at once the most enduring and the most easily destroyed of substances; its molecules are constantly breaking down to furnish the power for the manifestations of vital phenomena, and yet, through its remarkable property of assimilation, a power possessed by nothing else upon earth, it constantly builds up its substance anew from the surrounding medium.
In History of the Human Body (1919), 1.
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But in its [the corpuscular theory of radiation] relation to the wave theory there is one extraordinary and, at present, insoluble problem. It is not known how the energy of the electron in the X-ray bulb is transferred by a wave motion to an electron in the photographic plate or in any other substance on which the X-rays fall. It is as if one dropped a plank into the sea from the height of 100 ft. and found that the spreading ripple was able, after travelling 1000 miles and becoming infinitesimal in comparison with its original amount, to act upon a wooden ship in such a way that a plank of that ship flew out of its place to a height of 100 ft. How does the energy get from one place to the other?
'Aether Waves and Electrons' (Summary of the Robert Boyle Lecture), Nature, 1921, 107, 374.
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But to proceed; as in order and place, so also in matter of her Creation, Woman far excells Man. things receive their value from the matter they are made of, and the excellent skill of their maker: Pots of common clay must not contend with China-dishes, nor pewter utensils vye dignity with those of silver…. Woman was not composed of any inanimate or vile dirt, but of a more refined and purified substance, enlivened and actuated by a Rational Soul, whose operations speak it a beam, or bright ray of Divinity.
In Female Pre-eminence: Or, The Dignity and Excellency of that Sex above the Male, translation (1670).
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But, further, no animal can live upon a mixture of pure protein, fat and carbohydrate, and even when the necessary inorganic material is carefully supplied, the animal still cannot flourish. The animal body is adjusted to live either upon plant tissues or the tissues of other animals, and these contain countless substances other than the proteins, carbohydrates and fats... In diseases such as rickets, and particularly in scurvy, we have had for long years knowledge of a dietetic factor; but though we know how to benefit these conditions empirically, the real errors in the diet are to this day quite obscure. They are, however, certainly of the kind which comprises these minimal qualitative factors that I am considering.
'The Analyst and the Medical Man', The Analyst (1906), 31, 395-6.
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By blending water and minerals from below with sunlight and CO2 from above, green plants link the earth to the sky. We tend to believe that plants grow out of the soil, but in fact most of their substance comes from the air. The bulk of the cellulose and the other organic compounds produced through photosynthesis consists of heavy carbon and oxygen atoms, which plants take directly from the air in the form of CO2. Thus the weight of a wooden log comes almost entirely from the air. When we burn a log in a fireplace, oxygen and carbon combine once more into CO2, and in the light and heat of the fire we recover part of the solar energy that went into making the wood.
The Web of Life: A New Scientific Understanding of Living Systems (1997), 178.
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Chemical signs ought to be letters, for the greater facility of writing, and not to disfigure a printed book ... I shall take therefore for the chemical sign, the initial letter of the Latin name of each elementary substance: but as several have the same initial letter, I shall distinguish them in the following manner:— 1. In the class which I shall call metalloids, I shall employ the initial letter only, even when this letter is common to the metalloid and to some metal. 2. In the class of metals, I shall distinguish those that have the same initials with another metal, or a metalloid, by writing the first two letters of the word. 3. If the first two letters be common to two metals, I shall, in that case, add to the initial letter the first consonant which they have not in common: for example, S = sulphur, Si = silicium, St = stibium (antimony), Sn = stannum (tin), C = carbonicum, Co = colbaltum (colbalt), Cu = cuprum (copper), O = oxygen, Os = osmium, &c.
'Essay on the Cause of Chemical Proportions, and on some circumstances relating to them: together with a short and easy method of expressing them', Annals of Philosophy, 1814, 3,51-2.
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Chemistry is one of those branches of human knowledge which has built itself upon methods and instruments by which truth can presumably be determined. It has survived and grown because all its precepts and principles can be re-tested at any time and anywhere. So long as it remained the mysterious alchemy by which a few devotees, by devious and dubious means, presumed to change baser metals into gold, it did not flourish, but when it dealt with the fact that 56 g. of fine iron, when heated with 32 g. of flowers of sulfur, generated extra heat and gave exactly 88 g. of an entirely new substance, then additional steps could be taken by anyone. Scientific research in chemistry, since the birth of the balance and the thermometer, has been a steady growth of test and observation. It has disclosed a finite number of elementary reagents composing an infinite universe, and it is devoted to their inter-reaction for the benefit of mankind.
Address upon receiving the Perkin Medal Award, 'The Big Things in Chemistry', The Journal of Industrial and Engineering Chemistry (Feb 1921), 13, No. 2, 163.
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Chemistry works with an enormous number of substances, but cares only for some few of their properties; it is an extensive science. Physics on the other hand works with rather few substances, such as mercury, water, alcohol, glass, air, but analyses the experimental results very thoroughly; it is an intensive science. Physical chemistry is the child of these two sciences; it has inherited the extensive character from chemistry. Upon this depends its all-embracing feature, which has attracted so great admiration. But on the other hand it has its profound quantitative character from the science of physics.
In Theories of Solutions (1912), xix.
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Chemists show us that strange property, catalysis, which enables a substance while unaffected itself to incite to union elements around it. So a host, or hostess, who may know but little of those concerned, may, as a social switchboard, bring together the halves of pairs of scissors, men who become life-long friends, men and women who marry and are happy husbands and wives.
From chapter 'Jottings from a Note-book', in Canadian Stories (1918), 179.
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Carl Sagan quote A Subject Called Chemistry
Wellington College. CC by-NC 2.0 (source)
Chlorine is a deadly poison gas employed on European battlefields in World War I. Sodium is a corrosive metal which burns upon contact with water. Together they make a placid and unpoisonous material, table salt. Why each of these substances has the properties it does is a subject called chemistry.
In Broca's Brain: The Romance of Science (1979), 18, footnote.
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Compare ... the various quantities of the same element contained in the molecule of the free substance and in those of all its different compounds and you will not be able to escape the following law: The different quantities of the same element contained in different molecules are all whole multiples of one and the same quantity, which always being entire, has the right to be called an atom.
Sketch of a Course of Chemical Philosophy (1858), Alembic Club Reprint (1910), 11.
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Compounds of gaseous substances with each other are always formed in very simple ratios, so that representing one of the terms by unity, the other is 1, 2, or at most 3 ... The apparent contraction of volume suffered by gas on combination is also very simply related to the volume of one of them.
Mémoires de la Société d' Arcueil, 1809, 2, 233-4. Trans. Foundations of the Molecular Theory, Alembic Club Reprint, no. 4 (1950), 24.
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Considering it as thus established, that heat is not a substance, but a dynamical form of mechanical effect, we perceive that there must be an equivalence between mechanical work and heat, as between cause and effect.
In 'On the Dynamical Theory of Heat, with Numerical Results Deduced from Mr. Joule's Equivalent of a Thermal Unit, and M. Regnault's Observations on Steam' (1851). In Mathematical and Physical Papers (1882-1911), Vol. 1, 175.
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Dissection … teaches us that the body of man is made up of certain kinds of material, so differing from each other in optical and other physical characters and so built up together as to give the body certain structural features. Chemical examination further teaches us that these kinds of material are composed of various chemical substances, a large number of which have this characteristic that they possess a considerable amount of potential energy capable of being set free, rendered actual, by oxidation or some other chemical change. Thus the body as a whole may, from a chemical point of view, be considered as a mass of various chemical substances, representing altogether a considerable capital of potential energy.
From Introduction to A Text Book of Physiology (1876, 1891), Book 1, 1.
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Engineering is the art or science of utilizing, directing or instructing others in the utilization of the principles, forces, properties and substance of nature in the production, manufacture, construction, operation and use of things ... or of means, methods, machines, devices and structures ...
(1920}
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Eskimos living in a world of ice have no word at all for that substance—and this has been cited as evidence of their primitive mentality. But ice as such is of no interest to an Eskimo; what is of interest, indeed of vital importance, are the different kinds of ice with which he must deal virtually every day of his life.
As co-author with Floyd W. Matson, in The Human Connection (1979), 174. More often seen without explanatory context, as “The Eskimos live among ice all their lives but have no single word for ice,” for example, in Richard Brautigan, Trout Fishing in America, The Pill Versus the Springhill Mine Disaster, and In Watermelon Sugar (1989), 111.
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Every chemical substance, every plant, every animal in its growth, teaches the unity of the cause, the variety of appearance.
In 'History,' Essays: First Series (1841).
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Louis Pasteur quote: Every chemical substance, whether natural or artificial, falls into one of two major categories, according
Every chemical substance, whether natural or artificial, falls into one of two major categories, according to the spatial characteristic of its form. The distinction is between those substances that have a plane of symmetry and those that do not. The former belong to the mineral, the latter to the living world.
Pasteur Vallery-Radot (ed.), Oeuvres de Pasteur (1922-1939), Vol. I, 331. Quoted in Patrice Debré, Louis Pasteur, trans. Elborg Forster (1994), 261.
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Every natural scientist who thinks with any degree of consistency at all will, I think, come to the view that all those capacities that we understand by the phrase psychic activities (Seelenthiitigkeiten) are but functions of the brain substance; or, to express myself a bit crudely here, that thoughts stand in the same relation to the brain as gall does to the liver or urine to the kidneys. To assume a soul that makes use of the brain as an instrument with which it can work as it pleases is pure nonsense; we would then be forced to assume a special soul for every function of the body as well.
Carl Vogt
In Physiologische Briefe für Gelbildete aIle Stünde (1845-1847), 3 parts, 206. as translated in Frederick Gregory, Scientific Materialism in Nineteenth Century Germany (1977), 64.
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Every time a significant discovery is being made one sets in motion a tremendous activity in laboratories and industrial enterprises throughout the world. It is like the ant who suddenly finds food and walks back to the anthill while sending out material called food attracting substance. The other ants follow the path immediately in order to benefit from the finding and continue to do so as long as the supply is rich.
Nobel Banquet speech (10 Dec 1982). In Wilhelm Odelberg (ed.), Les Prix Nobel. The Nobel Prizes 1982 (1983)
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Fermentation is the exhalation of a substance through the admixture of a ferment which, by virtue of its spirit, penetrates the mass and transforms it into its own nature.
Die Alchemie des Andreas Ubavius, ein Lehrbuch der Chemie aus dem Jahre 1597, trans. E. Pietsch and A. Kotowsld (1964), 3-4. Joseph S. Froton, Proteins, Enzymes, Genes: The Interplay of Chemistry and Biology (1999), 119.
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Finally, since I thought that we could have all the same thoughts, while asleep, as we have while we are awake, although none of them is true at that time, I decided to pretend that nothing that ever entered my mind was any more true than the illusions of my dreams. But I noticed, immediately afterwards, that while I thus wished to think that everything was false, it was necessarily the case that I, who was thinking this, was something. When I noticed that this truth “I think, therefore I am” was so firm and certain that all the most extravagant assumptions of the sceptics were unable to shake it, I judged that I could accept it without scruple as the first principle of the philosophy for which I was searching. Then, when I was examining what I was, I realized that I could pretend that I had no body, and that there was no world nor any place in which I was present, but I could not pretend in the same way that I did not exist. On the contrary, from the very fact that I was thinking of doubting the truth of other things, it followed very evidently and very certainly that I existed; whereas if I merely ceased to think, even if all the rest of what I had ever imagined were true, I would have no reason to believe that I existed. I knew from this that I was a substance, the whole essence or nature of which was to think and which, in order to exist, has no need of any place and does not depend on anything material. Thus this self—that is, the soul by which I am what I am—is completely distinct from the body and is even easier to know than it, and even if the body did not exist the soul would still be everything that it is.
Discourse on Method in Discourse on Method and Related Writings (1637), trans. Desmond M. Clarke, Penguin edition (1999), Part 4, 24-5.
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For mathematics, in a wilderness of tragedy and change, is a creature of the mind, born to the cry of humanity in search of an invariant reality, immutable in substance, unalterable with time.
In The American Mathematical Monthly (1949), 56, 19. Excerpted in John Ewing (ed,), A Century of Mathematics: Through the Eyes of the Monthly (1996), 186.
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For there are two modes of acquiring knowledge, namely, by reasoning and experience. Reasoning draws a conclusion and makes us grant the conclusion, but does not make the conclusion certain, nor does it remove doubt so that the mind may rest on the intuition of truth, unless the mind discovers it by the path of experience; since many have the arguments relating to what can be known, but because they lack experience they neglect the arguments, and neither avoid what is harmful nor follow what is good. For if a man who has never seen fire should prove by adequate reasoning that fire burns and injures things and destroys them, his mind would not be satisfied thereby, nor would he avoid fire, until he placed his hand or some combustible substance in the fire, so that he might prove by experience that which reasoning taught. But when he has had actual experience of combustion his mind is made certain and rests in the full light of truth. Therefore reasoning does not suffice, but experience does.
Opus Majus [1266-1268], Part VI, chapter I, trans. R. B. Burke, The Opus Majus of Roger Bacon (1928), Vol. 2, 583.
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For what is that which we call evil but the absence of good? In the bodies of animals, disease and wounds mean nothing but the absence of health; for when a cure is effected, that does not mean that the evils which were present—namely, the diseases and wounds—go away from the body and dwell elsewhere: they altogether cease to exist; for the wound or disease is not a substance, but a defect in the fleshly substance,—the flesh itself being a substance, and therefore something good, of which those evils—that is, privations of the good which we call health—are accidents. Just in the same way, what are called vices in the soul are nothing but privations of natural good. And when they are cured, they are not transferred elsewhere: when they cease to exist in the healthy soul, they cannot exist anywhere else.
In Marcus Dods (ed.), J.F. Shaw (trans.), The Enchiridion of Augustine, Chap. 9, collected in The Works of Aurelius Augustine, Bishop of Hippo: A new translation (1873), Vol. 9, 181-182.
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Form may be of more account than substance. A lens of ice will focus a solar beam to a blaze.
From chapter 'Jottings from a Note-book', in Canadian Stories (1918), 167.
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Further study of the division phenomena requires a brief discussion of the material which thus far I have called the stainable substance of the nucleus. Since the term nuclear substance could easily result in misinterpretation..., I shall coin the term chromatin for the time being. This does not indicate that this substance must be a chemical compound of a definite composition, remaining the same in all nuclei. Although this may be the case, we simply do not know enough about the nuclear substances to make such an assumption. Therefore, we will designate as chromatin that substance, in the nucleus, which upon treatment with dyes known as nuclear stains does absorb the dye. From my description of the results of staining resting and dividing cells... it follows that the chromatin is distributed throughout the whole resting nucleus, mostly in the nucleoli, the network, and the membrane, but also in the ground-substance. In nuclear division it accumulates exclusively in the thread figures. The term achromatin suggests itself automatically for the unstainable substance of the nucleus. The terms chromatic and achromatic which will be used henceforth are thus explained.
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Gold and iron at the present day, as in ancient times, are the rulers of the world; and the great events in the world of mineral art are not the discovery of new substances, but of new and rich localities of old ones.
Lecture (26 Npv 1851), to the London Society of Arts, 'The General Bearing of the Great Exhibition on the Progress of Art and Science', collected in Lectures on the Results of the Great Exhibition of 1851' (1852), 3.
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He [Lord Bacon] appears to have been utterly ignorant of the discoveries which had just been made by Kepler’s calculations … he does not say a word about Napier’s Logarithms, which had been published only nine years before and reprinted more than once in the interval. He complained that no considerable advance had been made in Geometry beyond Euclid, without taking any notice of what had been done by Archimedes and Apollonius. He saw the importance of determining accurately the specific gravities of different substances, and himself attempted to form a table of them by a rude process of his own, without knowing of the more scientific though still imperfect methods previously employed by Archimedes, Ghetaldus and Porta. He speaks of the εὕρηκα of Archimedes in a manner which implies that he did not clearly appreciate either the problem to be solved or the principles upon which the solution depended. In reviewing the progress of Mechanics, he makes no mention either of Archimedes, or Stevinus, Galileo, Guldinus, or Ghetaldus. He makes no allusion to the theory of Equilibrium. He observes that a ball of one pound weight will fall nearly as fast through the air as a ball of two, without alluding to the theory of acceleration of falling bodies, which had been made known by Galileo more than thirty years before. He proposed an inquiry with regard to the lever,—namely, whether in a balance with arms of different length but equal weight the distance from the fulcrum has any effect upon the inclination—though the theory of the lever was as well understood in his own time as it is now. … He speaks of the poles of the earth as fixed, in a manner which seems to imply that he was not acquainted with the precession of the equinoxes; and in another place, of the north pole being above and the south pole below, as a reason why in our hemisphere the north winds predominate over the south.
From Spedding’s 'Preface' to De Interpretations Naturae Proœmium, in The Works of Francis Bacon (1857), Vol. 3, 511-512. [Note: the Greek word “εὕρηκα” is “Eureka” —Webmaster.]
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Hemoglobin is one of the most interesting chemical substances in the world—to me it is the most interesting of all.
In 'The Hemoglobin Molecule in Health and Disease', read 19 Apr 1951, Proceedings of the American Philosophical Society (15 Oct 1952), 96, No. 5, 556.
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Hence when a person is in great pain, the cause of which he cannot remove, he sets his teeth firmly together, or bites some substance between them with great vehemence, as another mode of violent exertion to produce a temporary relief. Thus we have the proverb where no help can be has in pain, 'to grin and abide;' and the tortures of hell are said to be attended with 'gnashing of teeth.'Describing a suggestion of the origin of the grin in the present form of a proverb, 'to grin and bear it.'
Zoonomia, Or, The Laws of Organic Life, in three parts (1803), Vol. 1, 330.
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How did I discover saccharin? Well, it was partly by accident and partly by study. I had worked a long time on the compound radicals and substitution products of coal tar... One evening I was so interested in my laboratory that I forgot about my supper till quite late, and then rushed off for a meal without stopping to wash my hands. I sat down, broke a piece of bread, and put it to my lips. It tasted unspeakably sweet. I did not ask why it was so, probably because I thought it was some cake or sweetmeat. I rinsed my mouth with water, and dried my moustache with my napkin, when, to my surprise the napkin tasted sweeter than the bread. Then I was puzzled. I again raised my goblet, and, as fortune would have it, applied my mouth where my fingers had touched it before. The water seemed syrup. It flashed on me that I was the cause of the singular universal sweetness, and I accordingly tasted the end of my thumb, and found it surpassed any confectionery I had ever eaten. I saw the whole thing at once. I had discovered some coal tar substance which out-sugared sugar. I dropped my dinner, and ran back to the laboratory. There, in my excitement, I tasted the contents of every beaker and evaporating dish on the table.
Interview with American Analyst. Reprinted in Pacific Record of Medicine and Surgery (1886), 1, No. 3, 78.
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I am an organic chemist, albeit one who adheres to the definition of organic chemistry given by the great Swedish chemist Berzelius, namely, the chemistry of substances found in living matter, and my science is one of the more abstruse insofar as it rests on concepts and employs a jargon neither of which is a part of everyday experience. Nevertheless, organic chemistry deals with matters of truly vital Importance and in some of its aspects with which I myself have been particularly concerned it may prove to hold the keys to Life itself.
In 'Synthesis in the Study of Nucleotides', Nobel Lecture, 11 December 1957. In Nobel Lectures: Chemistry 1942-1962 (1964), 522.
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I am convinced, by repeated observation, that marbles, lime-stones, chalks, marls, clays, sand, and almost all terrestrial substances, wherever situated, are full of shells and other spoils of the ocean.
'Second Discours: Histoire & Théorie de la Terre', Histoire Naturelle, Générale et Particulière, Avec la Description du Cabinet du Roi (1749), Vol. I, 76-77; Natural History, General and Particular (1785), Vol. I, trans. W. Smellie, 13.
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I called it ignose, not knowing which carbohydrate it was. This name was turned down by my editor. 'God-nose' was not more successful, so in the end 'hexuronic acid' was agreed upon. To-day the substance is called 'ascorbic acid' and I will use this name.
Studies on Biological Oxidation and Some of its Catalysts (C4 Dicarboxylic Acids, Vitamin C and P Etc.) (1937), 73.
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I have been driven to assume for some time, especially in relation to the gases, a sort of conducting power for magnetism. Mere space is Zero. One substance being made to occupy a given portion of space will cause more lines of force to pass through that space than before, and another substance will cause less to pass. The former I now call Paramagnetic & the latter are the diamagnetic. The former need not of necessity assume a polarity of particles such as iron has with magnetic, and the latter do not assume any such polarity either direct or reverse. I do not say more to you just now because my own thoughts are only in the act of formation, but this I may say: that the atmosphere has an extraordinary magnetic constitution, & I hope & expect to find in it the cause of the annual & diurnal variations, but keep this to yourself until I have time to see what harvest will spring from my growing ideas.
Letter to William Whewell, 22 Aug 1850. In L. Pearce Williams (ed.), The Selected Correspondence of Michael Faraday (1971), Vol. 2, 589.
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I have destroyed almost the whole race of frogs, which does not happen in that savage Batrachomyomachia of Homer. For in the anatomy of frogs, which, by favour of my very excellent colleague D. Carolo Fracassato, I had set on foot in order to become more certain about the membranous substance of the lungs, it happened to me to see such things that not undeservedly I can better make use of that [saying] of Homer for the present matter—
“I see with my eyes a work trusty and great.”
For in this (frog anatomy) owing to the simplicity of the structure, and the almost complete transparency of the vessels which admits the eye into the interior, things are more clearly shown so that they will bring the light to other more obscure matters.
De Pulmonibus (1661), trans. James Young, Proceedings of the Royal Society of Medicine (1929-30), 23, 7.
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I have repeatedly had cause to refer to certain resemblances between the phenomena of irritability in the vegetable kingdom and those of the animal body, thus touching a province of investigation which has hitherto been far too little cultivated. In the last instance, indeed, I might say animal and vegetable life must of necessity agree in all essential points, including the phenomena of irritability also, since it is established that the animal organism is constructed entirely and simply from the properties of these substances that all vital movements both of plants and animals are to be explained.
Lectures on the Physiology of Plants (1887), 600.
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I have satisfied myself that the [cosmic] rays are not generated by the formation of new matter in space, a process which would be like water running up a hill. Nor do they come to any appreciable amount from the stars. According to my investigations the sun emits a radiation of such penetrative power that it is virtually impossible to absorb it in lead or other substances. ... This ray, which I call the primary solar ray, gives rise to a secondary radiation by impact against the cosmic dust scattered through space. It is the secondary radiation which now is commonly called the cosmic ray, and comes, of course, equally from all directions in space. [The article continues: The phenomena of radioactivity are not the result of forces within the radioactive substances but are caused by this ray emitted by the sun. If radium could be screened effectively against this ray it would cease to be radioactive, he said.]
Quoted in 'Tesla, 75, Predicts New Power Source', New York Times (5 Jul 1931), Section 2, 1.
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I have tried to read philosophers of all ages and have found many illuminating ideas but no steady progress toward deeper knowledge and understanding. Science, however, gives me the feeling of steady progress: I am convinced that theoretical physics is actual philosophy. It has revolutionized fundamental concepts, e.g., about space and time (relativity), about causality (quantum theory), and about substance and matter (atomistics), and it has taught us new methods of thinking (complementarity) which are applicable far beyond physics.
Max Born
My Life & My Views (1968), 48.
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I hold every man a debtor to his profession; from the which as men of course do seek to receive countenance and profit, so ought they of duty to endeavour themselves, by way of amends, to be a help and ornament thereunto. This is performed, in some degree, by the honest and liberal practice of a profession; where men shall carry a respect not to descend into any course that is corrupt and unworthy thereof, and preserve themselves free from the abuses wherewith the same profession is noted to be infected: but much more is this performed, if a man be able to visit and strengthen the roots and foundation of the science itself; thereby not only gracing it in reputation and dignity, but also amplifying it in profession and substance.
Opening sentences of Preface, Maxims of Law (1596), in The Works of Francis Bacon: Law tracts. Maxims of the Law (1803), Vol. 4, 10.
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I must admit that when I chose the name, “vitamine,” I was well aware that these substances might later prove not to be of an amine nature. However, it was necessary for me to choose a name that would sound well and serve as a catchword, since I had already at that time no doubt about the importance and the future popularity of the new field.
The Vitamines translated by Harry Ennis Dubin (1922), 26, footnote.
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I propose to provide proof... that just as always an alcoholic ferment, the yeast of beer, is found where sugar is converted into alcohol and carbonic acid, so always a special ferment, a lactic yeast, is found where sugar is transformed into lactic acid. And, furthermore, when any plastic nitrogenated substance is able to transform sugar into that acid, the reason is that it is a suitable nutrient for the growth of the [lactic] ferment.
Comptes Rendus (1857), 45, 913.
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I recall my own emotions: I had just been initiated into the mysteries of the complex number. I remember my bewilderment: here were magnitudes patently impossible and yet susceptible of manipulations which lead to concrete results. It was a feeling of dissatisfaction, of restlessness, a desire to fill these illusory creatures, these empty symbols, with substance. Then I was taught to interpret these beings in a concrete geometrical way. There came then an immediate feeling of relief, as though I had solved an enigma, as though a ghost which had been causing me apprehension turned out to be no ghost at all, but a familiar part of my environment.
In Tobias Dantzig and Joseph Mazur (ed.), 'The Two Realities', Number: The Language of Science (1930, ed. by Joseph Mazur 2007), 254.
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I remember vividly my student days, spending hours at the light microscope, turning endlessly the micrometric screw, and gazing at the blurred boundary which concealed the mysterious ground substance where the secret mechanisms of cell life might be found.
Nobel Lecture, The Coming Age of the Cell, 12 Dec 1974
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I require a term to express those bodies which can pass to the electrodes, or, as they are usually called, the poles. Substances are frequently spoken of as being electro-negative, or electro-positive, according as they go under the supposed influence of a direct attraction to the positive or negative pole. But these terms are much too significant for the use to which I should have to put them; for though the meanings are perhaps right, they are only hypothetical, and may be wrong; and then, through a very imperceptible, but still very dangerous, because continual, influence, they do great injury to science, by contracting and limiting the habitual view of those engaged in pursuing it. I propose to distinguish these bodies by calling those anions which go to the anode of the decomposing body; and those passing to the cathode, cations; and when I have occasion to speak of these together, I shall call them ions.
Philosophical Transactions of the Royal Society of London, 1834, 124, 79.
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I tell my students, with a feeling of pride that I hope they will share, that the carbon, nitrogen, and oxygen that make up ninety-nine per cent of our living substance were cooked in the deep interiors of earlier generations of dying stars. Gathered up from the ends of the universe, over billions of years, eventually they came to form, in part, the substance of our sun, its planets, and ourselves. Three billion years ago, life arose upon the earth. It is the only life in the solar system.
From speech given at an anti-war teach-in at the Massachusetts Institute of Technology, (4 Mar 1969) 'A Generation in Search of a Future', as edited by Ron Dorfman for Chicago Journalism Review, (May 1969).
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I took a good clear piece of Cork and with a Pen-knife sharpen'd as keen as a Razor, I cut a piece of it off, and thereby left the surface of it exceeding smooth, then examining it very diligently with a Microscope, me thought I could perceive it to appear a little porous; but I could not so plainly distinguish them, as to be sure that they were pores, much less what Figure they were of: But judging from the lightness and yielding quality of the Cork, that certainly the texture could not be so curious, but that possibly, if I could use some further diligence, I might find it to be discernable with a Microscope, I with the same sharp Penknife, cut off from the former smooth surface an exceeding thin piece of it with a deep plano-convex Glass, I could exceedingly plainly perceive it to be all perforated and porous, much like a Honey-comb, but that the pores of it were not regular; yet it was not unlike a Honey-comb in these particulars.
First, in that it had a very little solid substance, in comparison of the empty cavity that was contain'd between, ... for the Interstitia or walls (as I may so call them) or partitions of those pores were neer as thin in proportion to their pores as those thin films of Wax in a Honey-comb (which enclose and constitute the sexangular cells) are to theirs.
Next, in that these pores, or cells, were not very deep, but constituted of a great many little Boxes, separated out of one continued long pore, by certain Diaphragms...
I no sooner discerned these (which were indeed the first microscopical pores I ever saw, and perhaps, that were ever seen, for I had not met with any Writer or Person, that had made any mention of them before this) but me thought I had with the discovery of them, presently hinted to me the true and intelligible reason of all the Phænomena of Cork.
Micrographia, or some Physiological Descriptions of Minute Bodies made by Magnifying Glasses with Observations and Inquiries thereupon (1665), 112-6.
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I wanted some new names to express my facts in Electrical science without involving more theory than I could help & applied to a friend Dr Nicholl [his doctor], who has given me some that I intend to adopt for instance, a body decomposable by the passage of the Electric current, I call an ‘electrolyte’ and instead of saying that water is electro chemically decomposed I say it is ‘electrolyzed’. The intensity above which a body is decomposed beneath which it conducts without decomposition I call the ‘Electrolyte intensity’ &c &c. What have been called: the poles of the battery I call the electrodes they are not merely surfaces of metal, but even of water & air, to which the term poles could hardly apply without receiving a new sense. Electrolytes must consist of two parts which during the electrolization, are determined the one in the one direction, and the other towards the poles where they are evolved; these evolved substances I call zetodes, which are therefore the direct constituents of electrolites.
Letter to William Whewell (24 Apr 1834). In Frank A. J. L. James (ed.), The Correspondence of Michael Faraday: Volume 2, 1832-1840 (1993), 176.
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If it is good to teach students about the chemical industry then why is it not good to assign ethical qualities to substances along with their physical and chemical ones? We might for instance say that CS [gas] is a bad chemical because it can only ever be used by a few people with something to protect against many people with nothing to lose. Terylene or indigotin are neutral chemicals. Under capitalism their production is an exploitive process, under socialism they are used for the common good. Penicillin is a good chemical.
Quoted in T. Pateman (ed.), Countercourse (1972), 215.
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If we wish to give an account of the atomic constitution of the aromatic compounds, we are bound to explain the following facts:
1) All aromatic compounds, even the most simple, are relatively richer in carbon than the corresponding compounds in the class of fatty bodies.
2) Among the aromatic compounds, as well as among the fatty bodies, a large number of homologous substances exist.
3) The most simple aromatic compounds contain at least six atoms of carbon.
4) All the derivatives of aromatic substances exhibit a certain family likeness; they all belong to the group of 'Aromatic compounds'. In cases where more vigorous reactions take place, a portion of the carbon is often eliminated, but the chief product contains at least six atoms of carbon These facts justify the supposition that all aromatic compounds contain a common group, or, we may say, a common nucleus consisting of six atoms of carbon. Within this nucleus a more intimate combination of the carbon atoms takes place; they are more compactly placed together, and this is the cause of the aromatic bodies being relatively rich in carbon. Other carbon atoms can be joined to this nucleus in the same way, and according to the same law, as in the case of the group of fatty bodies, and in this way the existence of homologous compounds is explained.
Bulletin de la Societé Chimique de France (1865), 1, 98. Trans. W. H. Brock.
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In every combustion there is disengagement of the matter of fire or of light. A body can burn only in pure air [oxygen]. There is no destruction or decomposition of pure air and the increase in weight of the body burnt is exactly equal to the weight of air destroyed or decomposed. The body burnt changes into an acid by addition of the substance that increases its weight. Pure air is a compound of the matter of fire or of light with a base. In combustion the burning body removes the base, which it attracts more strongly than does the matter of heat, which appears as flame, heat and light.
'Memoire sur la combustion en général', Mémoires de l'Académie des Sciences, 1777, 592. Reprinted in Oeuvres de Lavoisier (1864), Vol. 2, 225-33, trans. M. P. Crosland.
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In fact, whenever energy is transmitted from one body to another in time, there must be a medium or substance in which the energy exists after it leaves one body and before it reaches the other ... and if we admit this medium as an hypothesis, I think it ought to occupy a prominent place in our investigations, and that we ought to endeavour to construct a mental representation of all the details of its action, and this has been my constant aim in this treatise.
A Treatise on Electricity and Magnetism (1873), Vol. 2, 438.
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In its most primitive form, life is, therefore, no longer bound to the cell, the cell which possesses structure and which can be compared to a complex wheel-work, such as a watch which ceases to exist if it is stamped down in a mortar. No, in its primitive form life is like fire, like a flame borne by the living substance;—like a flame which appears in endless diversity and yet has specificity within it;—which can adopt the form of the organic world, of the lank grass-leaf and of the stem of the tree.
Address given at the 1913 meeting of the Koninklijke Akademie van Wetenschappen in Amsterdam. Trans. in G. Van Iterson, Jr, L. E. Den Dooren De Jong and A. J. Kluyver, Martinus Willem Beilerinck: His Life and Work (1940), 120.
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In my first publication I might have claimed that I had come to the conclusion, as a result of serious study of the literature and deep thought, that valuable antibacterial substances were made by moulds and that I set out to investigate the problem. That would have been untrue and I preferred to tell the truth that penicillin started as a chance observation. My only merit is that I did not neglect the observation and that I pursued the subject as a bacteriologist. My publication in 1929 was the starting-point of the work of others who developed penicillin especially in the chemical field.
'Penicillin', Nobel Lecture, 11 Dec 1945. In Nobel Lectures: Physiology or Medicine 1942-1962 (1964), 83.
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In one department of his [Joseph Black’s] lecture he exceeded any I have ever known, the neatness and unvarying success with which all the manipulations of his experiments were performed. His correct eye and steady hand contributed to the one; his admirable precautions, foreseeing and providing for every emergency, secured the other. I have seen him pour boiling water or boiling acid from a vessel that had no spout into a tube, holding it at such a distance as made the stream’s diameter small, and so vertical that not a drop was spilt. While he poured he would mention this adaptation of the height to the diameter as a necessary condition of success. I have seen him mix two substances in a receiver into which a gas, as chlorine, had been introduced, the effect of the combustion being perhaps to produce a compound inflammable in its nascent state, and the mixture being effected by drawing some string or wire working through the receiver's sides in an air-tight socket. The long table on which the different processes had been carried on was as clean at the end of the lecture as it had been before the apparatus was planted upon it. Not a drop of liquid, not a grain of dust remained.
In Lives of Men of Letters and Science, Who Flourished in the Time of George III (1845), 346-7.
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In order to pursue chemotherapy successfully we must look for substances which possess a high affinity and high lethal potency in relation to the parasites, but have a low toxicity in relation to the body, so that it becomes possible to kill the parasites without damaging the body to any great extent. We want to hit the parasites as selectively as possible. In other words, we must learn to aim and to aim in a chemical sense. The way to do this is to synthesize by chemical means as many derivatives as possible of relevant substances.
'Ueber den jetzigen Stand der Chemotherapie'. Berichte der Deutschen Chemischen Gesellschagt, 1909, 42, 17-47. Translated in B. Holmstedt and G. Liljestrand (eds.), Readings in Pharmacology (1963), 286.
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In other branches of science, where quick publication seems to be so much desired, there may possibly be some excuse for giving to the world slovenly or ill-digested work, but there is no such excuse in mathematics. The form ought to be as perfect as the substance, and the demonstrations as rigorous as those of Euclid. The mathematician has to deal with the most exact facts of Nature, and he should spare no effort to render his interpretation worthy of his subject, and to give to his work its highest degree of perfection. “Pauca sed matura” was Gauss’s motto.
In Presidential Address British Association for the Advancement of Science, Section A, (1890), Nature, 42, 467. [The Latin motto translates as “Few, but ripe”. —Webmaster]
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In our search after the Knowledge of Substances, our want of Ideas, that are suitable to such a way of proceeding, obliges us to a quite different method. We advance not here, as in the other (where our abstract Ideas are real as well as nominal Essences) by contemplating our Ideas, and considering their Relations and Correspondencies; that helps us very little, for the Reasons, and in another place we have at large set down. By which, I think it is evident, that Substances afford Matter of very little general Knowledge; and the bare Contemplation of their abstract Ideas, will carry us but a very little way in the search of Truth and Certainty. What then are we to do for the improvement of our Knowledge in Substantial beings? Here we are to take a quite contrary Course, the want of Ideas of their real essences sends us from our own Thoughts, to the Things themselves, as they exist.
An Essay Concerning Human Understanding (1690). Edited by Peter Nidditch (1975), Book 4, Chapter 12, Section 9, 644.
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In the hierarchy of the major poetic substances, it [plastic] figures as a disgraced material, lost between the effusiveness of rubber and the flat hardness of metal.
'Plastic', in Mythologies (1957), trans. Annette Lavers (1972), 98.
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In this manner the whole substance of our geometry is reduced to the definitions and axioms which we employ in our elementary reasonings; and in like manner we reduce the demonstrative truths of any other science to the definitions and axioms which we there employ.
In The Philosophy of the Inductive Sciences: Founded Upon Their History (1840), Vol. 1, 67.
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It has been demonstrated that a species of penicillium produces in culture a very powerful antibacterial substance which affects different bacteria in different degrees. Generally speaking it may be said that the least sensitive bacteria are the Gram-negative bacilli, and the most susceptible are the pyogenic cocci ... In addition to its possible use in the treatment of bacterial infections penicillin is certainly useful... for its power of inhibiting unwanted microbes in bacterial cultures so that penicillin insensitive bacteria can readily be isolated.
'On the Antibacterial Action of Cultures of a Penicillium, with Special Reference to their Use in the Isolation of B. Influenzae', British Journal of Experimental Pathology, 1929, 10, 235-6.
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It is a substance called Chlorophyll, the most wonderful substance in our world. A world without chlorophyll would be a world without the higher forms of life, and in such a world no life, save perhaps that of the lowest bacteria, could possibly endure. In fact, without this remarkable pigment the living world as at present constituted could not exist.
In Life: A Book for Elementary Students (1925, 2013), 28.
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It is by the aid of iron that we construct houses, cleave rocks, and perform so many other useful offices of life. But it is with iron also that wars, murders, and robberies are effected, and this, not only hand to hand, but from a distance even, by the aid of missiles and winged weapons, now launched from engines, now hurled by the human arm, and now furnished with feathery wings. This last I regard as the most criminal artifice that has been devised by the human mind; for, as if to bring death upon man with still greater rapidity, we have given wings to iron and taught it to fly. ... Nature, in conformity with her usual benevolence, has limited the power of iron, by inflicting upon it the punishment of rust; and has thus displayed her usual foresight in rendering nothing in existence more perishable, than the substance which brings the greatest dangers upon perishable mortality.
Natural History of Pliny, translation (1857, 1898) by John Bostock and H. T. Riley, 205-6.
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It is customary in physics to take geometry for granted, as if it were a branch of mathematics. But in substance geometry is the noblest branch of physics.
In Introduction to the Calculus (1922), 348, footnote.
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It is obvious that we know with certainty, that the Flütz [layered] and primitive mountains have been produced by a series of precipitations and depositions formed in succession; that they took place from water which covered the globe, existing always more or less generally, and containing the different substances which have been produced from them.
In New Theory of the Formation of Veins (1809), 110-1.
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It is one of the laws of life that each acquisition has its cost. No organism can exercise power without yielding up part of its substance. The physiological law of Transfer of Energy is the basis of human success and happiness. There is no action without expenditure of energy and if energy be not expended the power to generate it is lost. This law shows itself in a thousand ways in the life of man. The arm which is not used becomes palsied. The wealth which comes by chance weakens and destroys. The good which is unused turns to evil. The charity which asks no effort cannot relieve the misery she creates.
In The Strength of Being Clean: A Study of the Quest for Unearned Happiness (1900), 6.
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It must ... be admitted that very simple relations ... exist between the volumes of gaseous substances and the numbers of simple or compound molecules which form them. The first hypothesis to present itself in this connection, and apparently even the only admissible one, is the supposition that the number of integral molecules in any gases is always the same for equal volumes, or always proportional to the volumes. Indeed, if we were to suppose that the number of molecules contained in a given volume were different for different gases, it would scarcely be possible to conceive that the law regulating the distance of molecules could give in all cases relations so simple as those which the facts just detailed compel us to acknowledge between the volume and the number of molecules.
'Essay on a Manner of Determining the Relative Masses of the Elementary Molecules of Bodies, and the Proportions in which they enter into these Compounds', Journal de Physique, 1811, 73, 58-76. In Foundations of the Molecular Theory; Alembic Club Reprints, Number 4 (1923), 28-9.
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It will be a general expression of the facts that have been detailed, relating to the changes and transitions by electricity, in common philosophical language, to say, that hydrogen, the alkaline substances, the metals, and certain metallic oxides, are all attracted by negatively electrified metallic surfaces; and contrariwise, that oxygen and acid substances are attracted by positively electrified metallic surfaces and rejected by negatively electrified metallic surfaces; and these attractive and repulsive forces are sufficiently energetic to destroy or suspend the usual operation of elective affinity.
Bakerian Lecture, 'On Some Chemical Agencies of Electricity', Philosophical Transactions of the Royal Society, 1807, 97, 28-29.
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It will, perhaps appear probable, that one of the great laboratories of nature for cleaning and purifying the air of our atmosphere is placed in the substance of the leaves, and put in action by the influence of the light.
In Tobias George Smollett (ed.), 'Experiments Upon Vegetables', The Critical Review, Or, Annals of Literature (1779), 48, 336.
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It [the Euglena] is a perfect laboratory in itself, and it will act and react upon the water and the matters contained therein; converting them into new compounds resembling its own substance, and at the same time giving up portions of its own substance which have become effete.
From Address (22 Jul 1854) delivered at St. Martin’s Hall, published as a pamphlet (1854), 8, and collected in 'Educational Value of Natural History Sciences', Lay Sermons, Addresses, and Reviews (1870), 75.
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Just think of the differences today. A young person gets interested in chemistry and is given a chemical set. But it doesn't contain potassium cyanide. It doesn't even contain copper sulfate or anything else interesting because all the interesting chemicals are considered dangerous substances. Therefore, these budding young chemists don't get a chance to do anything engrossing with their chemistry sets. As I look back, I think it is pretty remarkable that Mr. Ziegler, this friend of the family, would have so easily turned over one-third of an ounce of potassium cyanide to me, an eleven-year-old boy.
In Barbara Marinacci, Linus Pauling In His Own Words (1995), 29.
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Let us ... consider the ovum [egg] as a physical system. Its potentialities are prodigious and one's first impulse is to expect that such vast potentialities would find expression in complexity of structure. But what do we find? The substance is clouded with particles, but these can be centrifuged away leaving it optically structureless but still capable of development.... On the surface of the egg there is a fine membrane, below it fluid of high viscosity, next fluid of relatively low viscosity, and within this the nucleus, which in the resting stage is simply a bag of fluid enclosed in a delicate membrane.... The egg's simplicity is not that of a machine or a crystal, but that of a nebula. Gathered into it are units relatively simple but capable by their combinations of forming a vast number of dynamical systems...
As guest of honour, closing day address (Jun 1928), Sixth Colloid Symposium, Toronto, Canada, 'Living Matter', printed in Harry Boyer Weiser (ed.), Colloid Symposium Monograph (1928), Vol. 6, 15. Quoted in Joseph Needham, Chemical Embryology (1931), Vol. 1, 612-613.
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Like taxes, radioactivity has long been with us and in increasing amounts; it is not to be hated and feared, but accepted and controlled. Radiation is dangerous, let there be no mistake about that—but the modern world abounds in dangerous substances and situations too numerous to mention. ... Consider radiation as something to be treated with respect, avoided when practicable, and accepted when inevitable.
Recommending the same view towards radiation as the risks of automobile travel.
While in the Office of Naval Research. In Must we Hide? (1949), 44.
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Magic is a faculty of wonderful virtue, full of most high mysteries, containing the most profound contemplation of most secret things, together with the nature, power, quality, substance and virtues thereof, as also the knowledge of whole Nature, and it doth instruct us concerning the differing and agreement of things amongst themselves, whence it produceth its wonderful effects, by uniting the virtues of things through the application of them one to the other.
In De Occulta Philosophia (1533), Vol. 1. Translation by J.F. (1651) reprinted as The Philosophy of Natural Magic (1913), 38-39.
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Mineral substances vary greatly in color, transparency, luster, brilliance, odor, taste, and other properties which are shown by their strength and weakness, shape, and form. They do not have the variety of origins that we find not only in living matter but also in original matter. Moreover they have not been classified like the latter on the basis of the place where they pass their life since mineral substances lack life and with rare exceptions are found only within the earth. They do not have the differences in characters and actions which nature has given to living things alone. Great differences are not the essential features of minerals as they are of living and original matter.
De Natura Fossilium (1546), trans. M. C. and J. A. Bandy (1955), 1.
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My main thesis will be that in the study of the intermediate processes of metabolism we have to deal not with complex substances which elude ordinary chemical methods, but with the simple substances undergoing comprehensible reactions... I intend also to emphasise the fact that it is not alone with the separation and identification of products from the animal that our present studies deal; but with their reactions in the body; with the dynamic side of biochemical phenomena.
'The Dynamic Side of Biochemistry', Address (11 Sep 1913) in Report on the 83rd Meeting of the British Association for the Advancement of Science (1914), 653.
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Nature being capricious and taking pleasure in creating and producing a continuous sucession of lives and forms because she knows that they serve to increase her terrestrial substance, is more ready and swift in her creating than time is in destroying, and therefore she has ordained that many animals shall serve as food one for the other; and as this does not satisfy her desire she sends forth frequently certain noisome and pestilential vapours and continual plagues upon the vast accumulations and herds of animals and especially upon human beings who increase very rapidly because other animals do not feed upon them.
'Philosophy', in The Notebooks of Leonardo da Vinci, trans. E. MacCurdy (1938), Vol. 1 80.
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Nature, from one aspect, is the wicked step-mother of the fairy tales, beguiling us and using us for her own purposes—the evolution of substances.
In On Love & Psychological Exercises: With Some Aphorisms & Other Essays (1998), 56.
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No scientist or student of science, need ever read an original work of the past. As a general rule, he does not think of doing so. Rutherford was one of the greatest experimental physicists, but no nuclear scientist today would study his researches of fifty years ago. Their substance has all been infused into the common agreement, the textbooks, the contemporary papers, the living present.
Attempting to distinguish between science and the humanities in which original works like Shakespeare's must be studied verbatim. 'The Case of Leavis and the Serious Case', (1970), reprinted in Public Affairs (1971), 94.
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Now if Light be reflected, not by impinging on the solid parts of Bodies, but by some other principle; it's probable that as many of its Rays as impinge on the solid parts of Bodies are not reflected but stifled and lost in the Bodies. For otherwise we must allow two sorts of Reflexions. Should all the Rays be reflected which impinge on the internal parts of clear Water or Crystal, those Substances would rather have a cloudy Colour than a clear Transparency. To make Bodies look black, it's necessary that many Rays be stopp'd, retained, and lost in them; and it seems not probable that any Rays can be stopp'd and stifled in them which do not impinge on their parts.
Opticks (1704), Book 2, Part 3, Prop. VIII, 69.
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Now it came to me: … the independence of the gravitational acceleration from the nature of the falling substance, may be expressed as follows: In a gravitational field (of small spatial extension) things behave as they do in a space free of gravitation. … This happened in 1908. Why were another seven years required for the construction of the general theory of relativity? The main reason lies in the fact that it is not so easy to free oneself from the idea that coordinates must have an immediate metrical meaning.
In Paul Arthur Schilpp, 'Autobiographical Notes', Albert Einstein: Philosopher-Scientist (1949), 65-67.
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Numbers have neither substance, nor meaning, nor qualities. They are nothing but marks, and all that is in them we have put into them by the simple rule of straight succession.
In 'Mathematics and the Laws of Nature', The Armchair Science Reader (1959), 301.
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Of all regions of the earth none invites speculation more than that which lies beneath our feet, and in none is speculation more dangerous; yet, apart from speculation, it is little that we can say regarding the constitution of the interior of the earth. We know, with sufficient accuracy for most purposes, its size and shape: we know that its mean density is about 5½ times that of water, that the density must increase towards the centre, and that the temperature must be high, but beyond these facts little can be said to be known. Many theories of the earth have been propounded at different times: the central substance of the earth has been supposed to be fiery, fluid, solid, and gaseous in turn, till geologists have turned in despair from the subject, and become inclined to confine their attention to the outermost crust of the earth, leaving its centre as a playground for mathematicians.
'The Constitution of the Interior of the Earth, as Revealed by Earthquakes', Quarterly Journal of the Geological Society (1906), 62, 456.
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Of all the constituents of the human body, bone is the hardest, the driest, the earthiest, and the coldest; and, excepting only the teeth, it is devoid of sensation. God, the great Creator of all things, formed its substance to this specification with good reason, intending it to be like a foundation for the whole body; for in the fabric of the human body bones perform the same function as do walls and beams in houses, poles in tents, and keels and ribs in boats.
Bones Differentiated by Function
Some bones, by reason of their strength, form as it were props for the body; these include the tibia, the femur, the spinal vertebrae, and most of the bony framework. Others are like bastions, defense walls, and ramparts, affording natural protection to other parts; examples are the skull, the spines and transverse processes of the vertebrae, the breast bone, the ribs. Others stand in front of the joints between certain bones, to ensure that the joint does not move too loosely or bend to too acute an angle. This is the function of the tiny bones, likened by the professors of anatomy to the size of a sesame seed, which are attached to the second internode of the thumb, the first internode of the other four fingers and the first internodes of the five toes. The teeth, on the other hand, serve specifically to cut, crush, pound and grind our food, and similarly the two ossicles in the organ of hearing perform a specifically auditory function.
From De Humani Corporis Fabrica Libri Septem: (1543), Book I, 1, as translated by William Frank Richardson, in 'Nature of Bone; Function of Bones', On The Fabric of the Human Body: Book I: The Bones and Cartilages (1998), 1.
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Of the nucleosides from deoxyribonucleic acids, all that was known with any certainty [in the 1940s] was that they were 2-deoxy-­D-ribosides of the bases adenine, guanine, thymine and cytosine and it was assumed that they were structurally analogous to the ribonucleosides. The chemistry of the nucleotides—the phosphates of the nucleosides—was in a correspondingly primitive state. It may well be asked why the chemistry of these groups of compounds was not further advanced, particularly since we recognize today that they occupy a central place in the history of the living cell. True, their full significance was for a long time unrecognized and emerged only slowly as biochemical research got into its stride but I think a more important reason is to be found in the physical properties of compounds of the nucleotide group. As water-soluble polar compounds with no proper melting points they were extremely difficult to handle by the classic techniques of organic chemistry, and were accordingly very discouraging substances to early workers. It is surely no accident that the major advances in the field have coincided with the appearance of new experimental techniques such as paper and ion-exchange chromatography, paper electrophoresis, and countercurrent distribution, peculiarly appropriate to the compounds of this group.
In 'Synthesis in the Study of Nucleotides', Nobel Lecture, 11 December 1957. In Nobel Lectures: Chemistry 1942-1962 (1964), 524.
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Of the Passive Principle, and Material Cause of the Small Pox ... Nature, in the first compounding and forming of us, hath laid into the Substance and Constitution of each something equivalent to Ovula, of various distinct Kinds, productive of all the contagious, venomous Fevers, we can possibly have as long as we live.
Exanthematologia: Or, An Attempt to Give a Rational Account of Eruptive Fevers, Especially of the Measles and SmallPox (1730), Part II, 'Of the Small-Pox', 175. In Ludvig Hektoen, 'Thomas Fuller 1654-1734: Country Physician and Pioneer Exponent of Specificness in Infection and Immunity', read to the Society (8 Nov 1921), published in Bulletin of the Society of Medical History of Chicago (Mar 1922), 2, 329, or in reprint form, p. 11.
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One in ten plant species contains anticancer substances of variable potency, but relatively few have been bioassayed.
In 'Edward O. Wilson: The Biological Diversity Crisis: A Challenge to Science', Issues in Science and Technology (Fall 1985), 2, No. 1, 25.
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One of the most immediate consequences of the electrochemical theory is the necessity of regarding all chemical compounds as binary substances. It is necessary to discover in each of them the positive and negative constituents... No view was ever more fitted to retard the progress of organic chemistry. Where the theory of substitution and the theory of types assume similar molecules, in which some of the elements can be replaced by others without the edifice becoming modified either in form or outward behaviour, the electrochemical theory divides these same molecules, simply and solely, it may be said, in order to find in them two opposite groups, which it then supposes to be combined with each other in virtue of their mutual electrical activity... I have tried to show that in organic chemistry there exist types which are capable, without destruction, of undergoing the most singular transformations according to the nature of the elements.
Traité de Chemie Appliquée aux Arts, Vol. I (1828), 53. Trans. J. R. Partington, A History of Chemistry, Vol. 4, 366.
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One reason which has led the organic chemist to avert his mind from the problems of Biochemistry is the obsession that the really significant happenings in the animal body are concerned in the main with substances of such high molecular weight and consequent vagueness of molecular structure as to make their reactions impossible of study by his available and accurate methods. There remains, I find, pretty widely spread, the feeling—due to earlier biological teaching—that, apart from substances which are obviously excreta, all the simpler products which can be found in cells or tissues are as a class mere objects, already too remote from the fundamental biochemical events to have much significance. So far from this being the case, recent progress points in the clearest way to the fact that the molecules with which a most important and significant part of the chemical dynamics of living tissues is concerned are of a comparatively simple character.
In 'The Dynamic Side of Biochemistry', Address (11 Sep 1913) in Report on the 83rd Meeting of the British Association for the Advancement of Science (1914), 657-8.
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People are entirely too disbelieving of coincidence. They are far too ready to dismiss it and to build arcane structures of extremely rickety substance in order to avoid it. I, on the other hand, see coincidence everywhere as an inevitable consequence of the laws of probability, according to which having no unusual coincidence is far more unusual than any coincidence could possibly be.
In The Planet That Wasn't (1976), 3.
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Physical chemistry is all very well, but it does not apply to organic substances.
Quoted in L. E. Sutton's obituary of Nevil V. Sidgwick, Proceedings of the Chemical Society (1958), 312.
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Poore soule, in this thy flesh what do'st thou know?
Thou know'st thy selfe so little, as thou know'st not.
How thou did'st die, nor how thou wast begot.
Thou neither know'st how thou at first camest in,
Nor how thou took'st the poyson of mans sin.
Nor dost thou, (though thou know'st, that thou art so)
By what way thou art made immortall, know.
Thou art too narrow, wretch, to comprehend
Even thy selfe; yea though thou wouldst but bend
To know thy body. Have not all soules thought
For many ages, that our body'is wrought
Of Ayre, and Fire, and other Elements?
And now they thinke of new ingredients,
And one soule thinkes one, and another way
Another thinkes, and 'tis an even lay.
Knowst thou but how the stone doth enter in
The bladder's Cave, and never breake the skin?
Knowst thou how blood, which to the hart doth flow,
Doth from one ventricle to th'other go?
And for the putrid stuffe, which thou dost spit,
Knowst thou how thy lungs have attracted it?
There are no passages, so that there is
(For aught thou knowst) piercing of substances.
And of those many opinions which men raise
Of Nailes and Haires, dost thou know which to praise?
What hope have we to know our selves, when wee
Know not the least things, which for our use bee?
Of the Progresse of the Soule. The Second Anniversarie, I. 254-280. The Works of John Donne (Wordsworth edition 1994), 196-7.
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Professor Cayley has since informed me that the theorem about whose origin I was in doubt, will be found in Schläfli’s De Eliminatione. This is not the first unconscious plagiarism I have been guilty of towards this eminent man whose friendship I am proud to claim. A more glaring case occurs in a note by me in the Comptes Rendus, on the twenty-seven straight lines of cubic surfaces, where I believe I have followed (like one walking in his sleep), down to the very nomenclature and notation, the substance of a portion of a paper inserted by Schlafli in the Mathematical Journal, which bears my name as one of the editors upon the face.
In Philosophical Transactions of the Royal Society (1864), 642.
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Sand is a substance that is beautiful, mysterious, and infinitely variable; each grain on a beach is the result of processes that go back into the shadowy beginnings of life, or of the earth itself.
In The Edge of the Sea (1955), 125.
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Scheele, it was said, never forgot anything if it had to do with chemistry. He never forgot the look, the feel, the smell of a substance, or the way it was transformed in chemical reactions, never forgot anything he read, or was told, about the phenomena of chemistry. He seemed indifferent, or inattentive, to most things else, being wholly dedicated to his single passion, chemistry. It was this pure and passionate absorption in phenomena—noticing everything, forgetting nothing—that constituted Scheele's special strength.
Uncle Tungsten: Memories of a Chemical Boyhood (2001), 44.
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Scripture and Nature agree in this, that all things were covered with water; how and when this aspect began, and how long it lasted, Nature says not, Scripture relates. That there was a watery fluid, however, at a time when animals and plants were not yet to be found, and that the fluid covered all things, is proved by the strata of the higher mountains, free from all heterogeneous material. And the form of these strata bears witness to the presence of a fluid, while the substance bears witness to the absence of heterogeneous bodies. But the similarity of matter and form in the strata of mountains which are different and distant from each other, proves that the fluid was universal.
The Prodromus of Nicolaus Steno's Dissertation Concerning a Solid Body enclosed by Process of Nature within a Solid (1669), trans. J. G. Winter (1916), 263-4.
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Should the research worker of the future discover some means of releasing this [atomic] energy in a form which could be employed, the human race will have at its command powers beyond the dream of scientific fiction, but the remotest possibility must always be considered that the energy once liberated will be completely uncontrollable and by its intense violence detonate all neighbouring substances. In this event, the whole of the hydrogen on earth might be transformed at once and the success of the experiment published at large to the universe as a new star.
'Mass Spectra and Isotopes', Nobel Lecture, 12 December 1922. In Nobel Lectures, Chemistry, 1922-1941 (1966), 20.
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Since it is necessary for specific ideas to have definite and consequently as far as possible selected terms, I have proposed to call substances of similar composition and dissimilar properties isomeric, from the Greek ίσομερης (composed of equal parts).
Jahrebericht (1832). As translated in Henry M. Leicester and Herbert S. Klickstein, A Source Book in Chemistry 1400-1900 (1952), 265.
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Since the discovery of secret things and in the investigation of hidden causes, stronger reasons are obtained from sure experiments and demonstrated arguments than from probable conjectures and the opinions of philosophical speculators of the common sort; therefore to the end that the noble substance of that great loadstone, our common mother (the earth), still quite unknown, and also the forces extraordinary and exalted of this globe may the better be understood, we have decided first to begin with the common stony and ferruginous matter, and magnetic bodies, and the parts of the earth that we may handle and may perceive with the senses; then to proceed with plain magnetic experiments, and to penetrate to the inner parts of the earth.
On the Loadstone and Magnetic Bodies and on the Great Magnet the Earth: A New Physiology, Demonstrated with many Arguments and Experiments (1600), trans. P. Fleury Mottelay (1893), Author’s Preface, xlvii.
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So says the most ancient book of the Earth; thus it is written on its leaves of marble, lime, sand, slate, and clay: ... that our Earth has fashioned itself, from its chaos of substances and powers, through the animating warmth of the creative spirit, to a peculiar and original whole, by a series of preparatory revolutions, till at last the crown of its creation, the exquisite and tender creature man, was enabled to appear.
Outlines of a Philosophy of the History of Man (1803). Translated from 1784 Original, Vol. I, Book 10, 465-6.
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Such is the substance of my faith; and if I were to sum up my credo in a single word, it would be that proud motto of Fustel de Coulanges, Quaero, I seek to learn.
From Conclusion of Presidential Address (29 Dec 1950) read at the annual dinner of the American Historical Association, Chicago, 'Faith of a Historian', The American Historical Review (Jan 1951), 56, No. 2, 261-275.
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Talent accumulates knowledge, and has it packed up in the memory; genius assimilates it with its own substance, grows with every new accession, and converts knowledge into power.
In 'Genius', Wellman’s Miscellany (Dec 1871), 4, No. 6, 203.
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Thales thought that water was the primordial substance of all things. Heraclitus of Ephesus… thought that it was fire. Democritus and his follower Epicurus thought that it was the atoms, termed by our writers “bodies that cannot be cut up” or, by some “indivisibles.” The school of the Pythagoreans added air and the earthy to the water and fire. Hence, although Democritus did not in a strict sense name them, but spoke only of indivisible bodies, yet he seems to have meant these same elements, because when taken by themselves they cannot be harmed, nor are they susceptible of dissolution, nor can they be cut up into parts, but throughout time eternal they forever retain an infinite solidity.
Vitruvius
In De Architectura, Book 2, Chap 2, Sec. 1. As translated in Morris Hicky Morgan (trans.), Vitruvius: The Ten Books on Architecture (1914), 42.
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That man is an Euclidian point: position without substance.
…...
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That special substance according to whose mass and degree of development all the creatures of this world take rank in the scale of creation, is not bone, but brain.
The Foot-prints of the Creator: Or, The Asterolepis of Stromness (1850, 1859), 160.
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The arguments for the two substances [mind and body] have, we believe, entirely lost their validity; they are no longer compatible with ascertained science and clear thinking. The one substance with two sets of properties, two sides, the physical and the mental—a double-faced unity—would appear to comply with all the exigencies of the case. … The mind is destined to be a double study—to conjoin the mental philosopher with the physical philosopher.
From concluding paragraph in Mind and Body: The Theories of their Relation (1872), 195.
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The bushels of rings taken from the fingers of the slain at the battle of Cannæ, above two thousand years ago, are recorded; … but the bushels of corn produced in England at this day, or the number of the inhabitants of the country, are unknown, at the very time that we are debating that most important question, whether or not there is sufficient substance for those who live in the kingdom.
In The Statistical Breviary: Shewing, on a Principle Entirely New, the Resources of Every State and Kingdom in Europe (1801), 7-8.
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The chemical compounds are comparable to a system of planets in that the atoms are held together by chemical affinity. They may be more or less numerous, simple or complex in composition, and in the constitution of the materials, they play the same role as Mars and Venus do in our planetary system, or the compound members such as our earth with its moon, or Jupiter with its satellites... If in such a system a particle is replaced by one of different character, the equilibrium can persist, and then the new compound will exhibit properties similar to those shown by the original substance.
Quoted in Ralph Oesper, The Human Side of Scientists (1975), 55.
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The conception of the atom stems from the concepts of subject and substance: there has to be “something” to account for any action. The atom is the last descendant of the concept of the soul.
Epigraph, without citation, in Edward C. Stark, Essential Chemistry (1979), 97. Also without citation in Isaac Asimov and Jason A. Shulman (eds.), Isaac Asimov’s Book of Science and Nature Quotations (1988), 32. Webmaster has not yet been able to identify the primary source (can you help?).
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The conception that antibodies, which should protect against disease, are also responsible for the disease, sounds at first absurd. This has as its basis the fact that we are accustomed to see in disease only the harm done to the organism and to see in the antibodies solely antitoxic [protective] substances. One forgets too easily that the disease represents only a stage in the development of immunity, and that the organism often attains the advantage of immunity only by means of disease. ... Serum sickness represents, so to speak, an unnatural (artificial) form of disease.
C. von Pirquet and B. Schick, Die Serumkrankheit (1906), trans B. Schick, Serum Sickness (1951), 119-20.
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The concepts of ‘soul’ or ‘life’ do not occur in atomic physics, and they could not, even indirectly, be derived as complicated consequences of some natural law. Their existence certainly does not indicate the presence of any fundamental substance other than energy, but it shows only the action of other kinds of forms which we cannot match with the mathematical forms of modern atomic physics ... If we want to describe living or mental processes, we shall have to broaden these structures. It may be that we shall have to introduce yet other concepts.
…...
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The demonstration that no possible combination of known substances, known forms of machinery and known forms of force, can be united in a practical machine by which men shall fly along distances through the air, seems to the writer as complete as it is possible for the demonstration to be.
Side-lights on Astronomy and Kindred Fields of Popular Science (1906), 345.
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The disaster was caused neither by carelessness nor human failure. Unknown natural factors that we are still unable to explain today have made a mockery of all our efforts. The very substance intended to provide food and life to millions of our countrymen and which we have produced and supplied for years has suddenly become a cruel enemy for reasons we are as yet unable to fathom. It has reduced our site to rubble.
From the memorial service for the hundreds of people killed by the explosion of the ammonia fertilizer factory at Oppau, Germany. At the time, the explosive nature of ammonium nitrate was not understood.
BASF corporate history webpage.
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The dogma of the impossibility of determining the atomic constitution of substances, which until recently was advocated with such fervor by the most able chemists, is beginning to be abandoned and forgotten; and one can predict that the day is not far in the future when a sufficient collection of facts will permit determination of the internal architecture of molecules. A series of experiments directed toward such a goal is the object of this paper.
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The electrical matter consists of particles extremely subtile, since it can permeate common matter, even the densest metals, with such ease and freedom as not to receive any perceptible resistance.
If anyone should doubt whether the electrical matter passes through the substance of bodies, or only over along their surfaces, a shock from an electrified large glass jar, taken through his own body, will probably convince him.
Electrical matter differs from common matter in this, that the parts of the latter mutually attract, those of the former mutually repel each other.
'Opinions and Conjectures, Concerning the Properties and Effects of the Electrical Matter, arising from Experiments and Observations, made at Philadelphia, 1749.' In I. Bernard Cohen (ed.), Benjamin Franklin's Experiments (1941), 213.
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The external world of physics has … become a world of shadows. In removing our illusions we have removed the substance, for indeed we have seen that substance is one of the greatest of our illusions. Later perhaps we may inquire whether in our zeal to cut out all that is unreal we may not have used the knife too ruthlessly. Perhaps, indeed, reality is a child which cannot survive without its nurse illusion. But if so, that is of little concern to the scientist, who has good and sufficient reasons for pursuing his investigations in the world of shadows and is content to leave to the philosopher the determination of its exact status in regard to reality.
In Introduction to The Nature of the Physical World (1928), xiv.
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The fibrous material and muscle were thus digested in the same way as the coagulated egg albumen, namely, by free acid in combination with another substance active in very small amounts. Since the latter really carries on the digestion of the most important animal nutrient materials, one might with justice apply to it the name pepsin.
'Ueber das Wesen des Verdauungsprocesses', Archiv für Anatomie, Physiologie und Wissenschaftliche Medicin (1836), 90-138. Trans. L. G. Wilson, 'The Discovery of Pepsin', in John F. Fulton and Leonard G. Wilson (eds.), Selected Readings in the History of Physiology (1966), 191.
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The final result of our researches has widened the class of substances sensitive to light vibrations, until we can propound the fact of such sensitiveness being a general property of all matter.
In Paper (27 Aug 1880) read to the American Association for the Advancement of Science, 'On the Production and Reproduction of Sound by Light'. Printed in The American Journal of Science (Oct 1880), 20, 3rd Ser., No. 118, 305.
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The great testimony of history shows how often in fact the development of science has emerged in response to technological and even economic needs, and how in the economy of social effort, science, even of the most abstract and recondite kind, pays for itself again and again in providing the basis for radically new technological developments. In fact, most people—when they think of science as a good thing, when they think of it as worthy of encouragement, when they are willing to see their governments spend substance upon it, when they greatly do honor to men who in science have attained some eminence—have in mind that the conditions of their life have been altered just by such technology, of which they may be reluctant to be deprived.
In 'Contemporary World', Bulletin of the Atomic Scientists (Feb 1948), 4, 67.
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The heat produced in maximal muscular effort, continued for twenty minutes, would be so great that, if it were not promptly dissipated, it would cause some of the albuminous substances of the body to become stiff, like a hard-boiled egg.
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The inducing substance, on the basis of its chemical and physical properties, appears to be a highly polymerized and viscous form of sodium desoxyribonucleate. On the other hand, the Type m capsular substance, the synthesis of which is evoked by this transforming agent, consists chiefly of a non-nitrogenous polysaccharide constituted of glucose-glucuronic acid units linked in glycosidic union. The presence of the newly formed capsule containing this type-specific polysaccharide confers on the transformed cells all the distinguishing characteristics of Pneumococcus Type III. Thus, it is evident that the inducing substance and the substance produced in turn are chemically distinct and biologically specific in their action and that both are requisite in determining the type of specificity of the cell of which they form a part. The experimental data presented in this paper strongly suggest that nucleic acids, at least those of the desoxyribose type, possess different specificities as evidenced by the selective action of the transforming principle.
Oswald T. Avery (1877-1955), Colin Macleod (1909-72) and Maclyn McCarty (1911-2005), ‘Studies in the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types', Journal of Experimental Medicine 1944, 79, 152.
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The inherent unpredictability of future scientific developments—the fact that no secure inference can be drawn from one state of science to another—has important implications for the issue of the limits of science. It means that present-day science cannot speak for future science: it is in principle impossible to make any secure inferences from the substance of science at one time about its substance at a significantly different time. The prospect of future scientific revolutions can never be precluded. We cannot say with unblinking confidence what sorts of resources and conceptions the science of the future will or will not use. Given that it is effectively impossible to predict the details of what future science will accomplish, it is no less impossible to predict in detail what future science will not accomplish. We can never confidently put this or that range of issues outside “the limits of science”, because we cannot discern the shape and substance of future science with sufficient clarity to be able to say with any assurance what it can and cannot do. Any attempt to set “limits” to science—any advance specification of what science can and cannot do by way of handling problems and solving questions—is destined to come to grief.
The Limits of Science (1984), 102-3.
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The initiation of the fermentation process does not require so complicated an apparatus as is represented by the living cell. The agent responsible for the fermenting action of the press juice is rather to be regarded as a dissolved substance, doubtless a protein; this will be denoted zymase.
'Gahrung ohne Hefezellen', Berichte der deutschen chemischen Gesellschaft, 1897, 30, 119-20. Trans. in Joseph S. Froton, Proteins, Enzymes, Genes: The Interplay of Chemistry and Biology (1999), 117.
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The injurious agent in cigarettes comes principally from the burning paper wrapper. The substance thereby formed is called “acrolein.” It has a violent action on the nerve centers, producing degeneration of the cells of the brain, which is quite rapid among boys. Unlike most narcotics, this degeneration is permanent and uncontrollable. I employ no person who smokes cigarettes.
[From the Laboratory of Thomas A. Edison, Orange, N.J., April 26, 1914.]
Quoted in Henry Ford, The Case Against the Little White Slaver (1914), Vol. 1, 5.
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The man in the street will, therefore, twist the statement that the scientist has come to the end of meaning into the statement that the scientist has penetrated as far as he can with the tools at his command, and that there is something beyond the ken of the scientist. This imagined beyond, which the scientist has proved he cannot penetrate, will become the playground of the imagination of every mystic and dreamer. The existence of such a domain will be made the basis of an orgy of rationalizing. It will be made the substance of the soul; the spirits of the dead will populate it; God will lurk in its shadows; the principle of vital processes will have its seat here; and it will be the medium of telepathic communication. One group will find in the failure of the physical law of cause and effect the solution of the age-long problem of the freedom of the will; and on the other hand the atheist will find the justification of his contention that chance rules the universe.
Reflections of a Physicist (1950),102-3.
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The mathematics of cooperation of men and tools is interesting. Separated men trying their individual experiments contribute in proportion to their numbers and their work may be called mathematically additive. The effect of a single piece of apparatus given to one man is also additive only, but when a group of men are cooperating, as distinct from merely operating, their work raises with some higher power of the number than the first power. It approaches the square for two men and the cube for three. Two men cooperating with two different pieces of apparatus, say a special furnace and a pyrometer or a hydraulic press and new chemical substances, are more powerful than their arithmetical sum. These facts doubtless assist as assets of a research laboratory.
Quoted from a speech delivered at the fiftieth anniversary of granting of M.I.T's charter, in Guy Suits, 'Willis Rodney Whitney', National Academy of Sciences, Biographical Memoirs (1960), 352.
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The mineral kingdom consists of the fossil substances found in the earth. These are either entirely destitute of organic structure, or, having once possessed it, possess it no longer: such are the petrefactions.
In Outlines of Mineralogy (1783), trans. William Withering, 5. [Before it was specifically used for the petrified remains of organic forms, the word “fossil”—obsolete, as used here—refers to that which is “dug from the earth, preserved in the ground.” —Webmaster] Also collected in William Withering (the son, ed.), The Miscellaneous Tracts of the Late William Withering (1822), Vol. 2, 9.
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The most startling result of Faraday’s Law is perhaps this. If we accept the hypothesis that the elementary substances are composed of atoms, we cannot avoid concluding that electricity also, positive as well as negative, is divided into definite elementary portions, which behave like atoms of electricity.
Faraday Lecture (1881). In 'On the Modern Development of Faraday's Conception of Electricity', Journal of the Chemical Society 1881, 39, 290. It is also stated in the book by Laurie M. Brown, Abraham Pais and Brian Pippard, Twentieth Century P, Vol. 1, 52, that this is 'a statement which explains why in subsequent years the quantity e was occasionally referred to in German literature as das Helmholtzsche Elementarquantum'.
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The nature of heredity is based upon the transmission of nuclear substance with a specific molecular constitution. This substance is the specific nucleoplasm of the germ-cell, to which I have given the name of germ-plasm.
Trans. Joseph S. Froton, Proteins, Enzymes, Genes: The Interplay of Chemistry and Biology (1999), 391.
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The next object which I have observed is the essence or substance of the Milky Way. By the aid of a telescope anyone may behold this in a manner which so distinctly appeals to the senses that all the disputes which have tormented philosophers through so many ages are exploded at once by the irrefragable evidence of our eyes, and we are freed from wordy disputes upon this subject, for the Galaxy is nothing else but a mass of innumerable stars planted together in clusters.
In pamphlet, The Sidereal Messenger (1610), reprinted in The Sidereal Messenger of Galileo Galilei: And a Part of the Preface to the Preface to Kepler's Dioptrics Containing the Original Account of Galileo's Astronomical Discoveries (1880), 42.
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The night before Easter Sunday of that year (1920) I awoke, turned on the light, and jotted down a few notes on a tiny slip of thin paper. Then I fell asleep again. It occurred to me at six o’clock in the morning that during the night I had written down something most important, but I was unable to decipher the scrawl. The next night, at three o’clock, the idea returned. It was the design of an experiment to determine whether the hypothesis of chemical transmission that I had uttered seventeen years ago was correct. I got up immediately, went to the laboratory, and performed a simple experiment on a frog heart according to the nocturnal design. I have to describe this experiment briefly since its results became the foundation of the theory of chemical transmission of the nervous impulse. The hearts of two frogs were isolated, the first with its nerves, the second without. Both hearts were attached to Straub cannulas filled with a little Ringer solution. The vagus nerve of the first heart was stimulated for a few minutes. Then the Ringer solution that had been in the first heart during the stimulation of the vagus was transferred to the second heart. It slowed and its beats diminished just as if its vagus had been stimulated. Similarly, when the accelerator nerve was stimulated and the Ringer from this period transferred, the second heart speeded up and its beats increased. These results unequivocally proved that the nerves do not influence the heart directly but liberate from their terminals specific chemical substances which, in their turn, cause the well-known modifications of the function of the heart characteristic of the stimulation of its nerves.
'An Autobiographic Sketch', Perspectives in Biology and Medicine (1960), 4, 17.
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THE OATH. I swear by Apollo [the healing God], the physician and Aesclepius [son of Apollo], and Health [Hygeia], and All-heal [Panacea], and all the gods and goddesses, that, according to my ability and judgment, I will keep this Oath and this stipulation—to reckon him who taught me this Art equally dear to me as my parents, to share my substance with him, and relieve his necessities if required; to look upon his offspring in the same footing as my own brothers, and to teach them this art, if they shall wish to learn it, without fee or stipulation; and that by precept, lecture, and every other mode of instruction, I will impart a knowledge of the Art to my own sons, and those of my teachers, and to disciples bound by a stipulation and oath according to the law of medicine, but to none others. I will follow that system of regimen which, according to my ability and judgment, I consider for the benefit of my patients, and abstain from whatever is deleterious and mischievous. I will give no deadly medicine to any one if asked, nor suggest any such counsel; and in like manner I will not give to a woman a pessary to produce abortion. With purity and with holiness I will pass my life and practice my Art. I will not cut persons laboring under the stone, but will leave this to be done by men who are practitioners of this work. Into whatever houses I enter, I will go into them for the benefit of the sick, and will abstain from every voluntary act of mischief and corruption; and, further, from the seduction of females or males, of freemen and slaves. Whatever, in connection with my professional practice or not, in connection with it, I see or hear, in the life of men, which ought not to be spoken of abroad, I will not divulge, as reckoning that all such should be kept secret. While I continue to keep this Oath unviolated, may it be granted to me to enjoy life and the practice of the art, respected by all men, in all times! But should I trespass and violate this Oath, may the reverse be my lot!
The Genuine Works of Hippocrates, trans. Francis Adams (1886), Vol. 2, 344-5.
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The only sure foundations of medicine are, an intimate knowledge of the human body, and observation on the effects of medicinal substances on that. The anatomical and clinical schools, therefore, are those in which the young physician should be formed. If he enters with innocence that of the theory of medicine, it is scarcely possible he should come out untainted with error. His mind must be strong indeed, if, rising above juvenile credulity, it can maintain a wise infidelity against the authority of his instructors, and the bewitching delusions of their theories.
In letter to Caspar Wistar (21 Jun 1807), collected in Thomas Jefferson Randolph (ed.), Memoir, Correspondence, And Miscellanies, From The Papers Of Thomas Jefferson (1829), Vol. 4, 93.
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The opinion I formed from attentive observation of the facts and phenomena, is as follows. When ice, for example, or any other solid substance, is changing into a fluid by heat, I am of opinion that it receives a much greater quantity of heat than that what is perceptible in it immediately after by the thermometer. A great quantity of heat enters into it, on this occasion, without making it apparently warmer, when tried by that instrument. This heat, however, must be thrown into it, in order to give it the form of a fluid; and I affirm, that this great addition of heat is the principal, and most immediate cause of the fluidity induced. And, on the other hand, when we deprive such a body of its fluidity again, by a diminution of its heat, a very great quantity of heat comes out of it, while it is assuming a solid form, the loss of which heat is not to be perceived by the common manner of using the thermometer. The apparent heat of the body, as measured by that instrument, is not diminished, or not in proportion to the loss of heat which the body actually gives out on this occasion; and it appears from a number of facts, that the state of solidity cannot be induced without the abstraction of this great quantity of heat. And this confirms the opinion, that this quantity of heat, absorbed, and, as it were, concealed in the composition of fluids, is the most necessary and immediate cause of their fluidity.
Lectures on the Elements of Chemistry, delivered in the University of Edinburgh (1803), Vol. I, 116-7.
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The physiological combustion theory takes as its starting point the fundamental principle that the amount of heat that arises from the combustion of a given substance is an invariable quantity–i.e., one independent of the circumstances accompanying the combustion–from which it is more specifically concluded that the chemical effect of the combustible materials undergoes no quantitative change even as a result of the vital process, or that the living organism, with all its mysteries and marvels, is not capable of generating heat out of nothing.
Bemerkungen über das mechanische Aequivalent der Wärme [Remarks on the Mechanical Equivalent of Heat] (1851), 17-9. Trans. Kenneth L. Caneva, Robert Mayer and the Conservation of Energy (1993), 240.
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The plant cell, like the animal cell, is a type of laboratory of cellular tissues that organize themselves and develop within its innermost substance; its imperforate walls, to judge from our strongest magnifying instruments, have the property of drawing out by aspiration from the ambient liquid the elements necessary for its elaboration. They thus have the property of acting as a sorter, of admitting certain substances and preventing the passage of others, and consequently of separating the elements of certain combinations in order to admit only a portion of them.
As quoted in article Marc Klein,'François-Vincent Raspail', in Charles Coulston Gillispie (ed.), Dictionary of Scientific Biography (1975). Vol.11, 300.
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The precise equivalence of the chromosomes contributed by the two sexes is a physical correlative of the fact that the two sexes play, on the whole, equal parts in hereditary transmission, and it seems to show that the chromosomal substance, the chromatin, is to be regarded as the physical basis of inheritance. Now, chromatin is known to be closely similar to, if not identical with, a substance known as nuclein (C29H49N9O22, according to Miescher), which analysis shows to be a tolerably definite chemical compased of nucleic acid (a complex organic acid rich in phosphorus) and albumin. And thus we reach the remarkable conclusion that inheritance may, perhaps, be effected by the physical transmission of a particular chemical compound from parent to offspring.
In An Atlas of the Fertilization and Karyokinesis of the Ovum (1895), 4.
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The progress of synthesis, or the building up of natural materials from their constituent elements, proceeds apace. Even some of the simpler albuminoids, a class of substances of great importance in the life process, have recently been artificially prepared. ... Innumerable entirely new compounds have been produced in the last century. The artificial dye-stuffs, prepared from materials occurring in coal-tar, make the natural colours blush. Saccharin, which is hundreds of times sweeter than sugar, is a purely artificial substance. New explosives, drugs, alloys, photographic substances, essences, scents, solvents, and detergents are being poured out in a continuous stream.
In Matter and Energy (1912), 45-46.
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The purely formal sciences, logic and mathematics, deal with such relations which are independent of the definite content, or the substance of the objects, or at least can be. In particular, mathematics involves those relations of objects to each other that involve the concept of size, measure, number.
In Theorie der Complexen Zahlensysteme, (1867), 1. Translated by Webmaster using Google Translate from the original German, “Die rein formalen Wissenschaften, Logik und Mathematik, haben solche Relationen zu behandeln, welche unabhängig von dem bestimmten Inhalte, der Substanz der Objecte sind oder es wenigstens sein können.”
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The purely formal Sciences, logic and mathematics, deal with those relations which are, or can be, independent of the particular content or the substance of objects. To mathematics in particular fall those relations between objects which involve the concepts of magnitude, of measure and of number.
In Theorie der Complexen Zahlensysteme (1867), 1. As translated in Robert Édouard Moritz, Memorabilia Mathematica; Or, The Philomath’s Quotation-book (1914), 4. From the original German, “Die rein formalen Wissenschaften, Logik und Mathematik, haben solche Relationen zu behandeln, welche unabhängig von dem bestimmten Inhalte, der Substanz der Objecte sind oder es wenigstens sein können. Der Mathematik fallen ins Besondere diejenigen Beziehungen der Objecte zu einander zu, die den Begriff der Grösse, des Maasses, der Zahl involviren.”
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The question of a possible physiological significance, in the resemblance between the action of choline esters and the effects of certain divisions of the involuntary nervous system, is one of great interest, but one for the discussion of which little evidence is available. Acetyl-choline is, of all the substances examined, the one whose action is most suggestive in this direction. The fact that its action surpasses even that of adrenaline, both in intensity and evanescence, when considered in conjunction with the fact that each of these two bases reproduces those effects of involuntary nerves which are absent from the action of the other, so that the two actions are in many directions at once complementary and antagonistic, gives plenty of scope for speculation.
In 'The Action of Certain Esters and Ethers of Choline, and Their Relation to Muscarine', The Journal of Pharmacology and Experimental Therapeutics, 1914-15, 6, 188.
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The reactions follow a pattern, which is valid for the blood of all humans... Basically, in fact, there are four different types of human blood, the so-called blood groups. The number of the groups follows from the fact that the erythrocytes evidently contain substances (iso-agglutinogens) with two different structures, of which both may be absent, or one or both present, in the erythrocytes of a person. This alone would still not explain the reactions; the active substances of the sera, the iso-agglutinins, must also be present in a specific distribution. This is actually the case, since every serum contains those agglutinins which react with the agglutinogens not present in the cells—a remarkable phenomenon, the cause of which is not yet known for certain.
'On Individual Differences in Human Blood', Nobel Lecture (11 Dec 1930). In Nobel Lectures: Physiology or Medicine 1922-1941 (1965), 235.
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The responsibility for maintaining the composition of the blood in respect to other constituents devolves largely upon the kidneys. It is no exaggeration to say that the composition of the blood is determined not by what the mouth ingests but by what the kidneys keep; they are the master chemists of our internal environment, which, so to speak, they synthesize in reverse. When, among other duties, they excrete the ashes of our body fires, or remove from the blood the infinite variety of foreign substances which are constantly being absorbed from our indiscriminate gastrointestinal tracts, these excretory operations are incidental to the major task of keeping our internal environment in an ideal, balanced state. Our glands, our muscles, our bones, our tendons, even our brains, are called upon to do only one kind of physiological work, while our kidneys are called upon to perform an innumerable variety of operations. Bones can break, muscles can atrophy, glands can loaf, even the brain can go to sleep, without immediately endangering our survival, but when the kidneys fail to manufacture the proper kind of blood neither bone, muscle, gland nor brain can carry on.
'The Evolution of the Kidney', Lectures on the Kidney (1943), 3.
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The ridge of the Lammer-muir hills... consists of primary micaceous schistus, and extends from St Abb's head westward... The sea-coast affords a transverse section of this alpine tract at its eastern extremity, and exhibits the change from the primary to the secondary strata... Dr HUTTON wished particularly to examine the latter of these, and on this occasion Sir JAMES HALL and I had the pleasure to accompany him. We sailed in a boat from Dunglass ... We made for a high rocky point or head-land, the SICCAR ... On landing at this point, we found that we actually trode [sic] on the primeval rock... It is here a micaceous schistus, in beds nearly vertical, highly indurated, and stretching from S.E. to N. W. The surface of this rock... has thin covering of red horizontal sandstone laid over it, ... Here, therefore, the immediate contact of the two rocks is not only visible, but is curiously dissected and laid open by the action of the waves... On us who saw these phenomena for the first time, the impression will not easily be forgotten. The palpable evidence presented to us, of one of the most extraordinary and important facts in the natural history of the earth, gave a reality and substance to those theoretical speculations, which, however probable had never till now been directly authenticated by the testimony of the senses... What clearer evidence could we have had of the different formation of these rocks, and of the long interval which separated their formation, had we actually seen them emerging from the bosom of the deep? ... The mind seemed to grow giddy by looking so far into the abyss of time; and while we listened with earnestness and admiration to the philosopher who was now unfolding to us the order and series of these wonderful events, we became sensible how much farther reason may sometimes go than imagination can venture to follow.
'Biographical Account of the Late Dr James Hutton, F.R.S. Edin.' (read 1803), Transactions of the Royal Society of Edinburgh (1805), 5, 71-3.
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The serum, when subjected to heat, coagulates and hardens like egg. This property is one of its striking characteristics; it is attributed to a particular substance which is thereby readily recognizable, and which is called albumine, because it is the one present in egg white, termed albumen.
Système des Connaissances Chimiques (1801), Vol. 5, 117. Trans. Joseph S. Fmton, Proteins, Enzymes, Genes: The Interplay of Chemistry and Biology (1999), 161.
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The soul seems to be a very tenuous substance … [and] seems to be made of a most subtle texture, extremely mobile or active corpuscles, not unlike those of flame or heat; indeed, whether they are spherical, as the authors of atoms propound, or pyramidical as Plato thought, or some other form, they seem from their own motion and penetration through bodies to create the heat which is in the animal.
As quoted in Margaret J. Osler and Paul Lawrence Farber (eds.), Religion, Science, and Worldview: Essays in Honor of Richard S. Westfall (2002), 169.
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The specific character of the greater part of the toxins which are known to us (I need only instance such toxins as those of tetanus and diphtheria) would suggest that the substances produced for effecting the correlation of organs within the body, through the intermediation of the blood stream, might also belong to this class, since here also specificity of action must be a distinguishing characteristic. These chemical messengers, however, or 'hormones' (from όρμάω, I excite or arouse), as we might call them, have to be carried from the organ where they are produced to the organ which they affect by means of the blood stream and the continually recurring physiological needs of the organism must determine their repeated production and circulation through the body.
'The Chemical Correlation of the Functions of the Body', The Lancet (1905), ii, 340.
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The study of the radio-active substances and of the discharge of electricity through gases has supplied very strong experimental evidence in support of the fundamental ideas of the existing atomic theory. It has also indicated that the atom itself is not the smallest unit of matter, but is a complicated structure made up of a number of smaller bodies.
In Radio-activity (1905), 1.
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The synthesis of substances occurring in Nature, perhaps in greater measure than activities in any other area of organic chemistry, provides a measure of the conditions and powers of science.
Synthesis', in A. Todd (ed.), Perspectives in Organic Chemistry (1956), 155.
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The term element is applied in chemistry to those forms of matter which have hitherto resisted all attempts to decompose them. Nothing is ever meant to be affirmed concerning their real nature; they are simply elements to us at the present time; hereafter, by new methods of research, or by new combinations of those already possessed by science, many of the substances which now figure as elements may possibly be shown to be compounds; this has already happened, and may again take place.
In Elementary Chemistry, Theoretical and Practical (1854), 103. There follows on this page, 62 listed elements, some indicated as “of recent discovery and yet imperfectly known”. Two of the later names were Norium and Pelopium.
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The varieties of chemical substances actually found in living things are vastly more restricted than the possible varieties. A striking illustration is that if one molecule each of all the possible types of proteins were made, they would together weigh more than the observable universe. Obviously there are a fantastically large number of protein types that are not made by living cells.
In The Closing Circle: Nature, Man, and Technology (2014).
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The various reasons which we have enumerated lead us to believe that the new radio-active substance contains a new element which we propose to give the name of radium.
Marie Curie, Pierre Curie and Gustave Bémont, 'Sur une Nouvelle Substance Fortement Radio-Active, Contenue dans las Pechblende', (On a new, strongly radio-active substance, contained in pitchblende), Comptes Rendus (1898). 127, 1217. In Joseph E. Harmon and Alan G. Gross (editors), The Scientific Literature (2007), 151.
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The White medullary Substance of the Brain is also the immediate Instrument, by which Ideas are presented to the Mind: Or, in other Words, whatever Changes are made in this Substance, corresponding Changes are made in our Ideas; and vice versa.
Observations on Man, His Frame, His Duty, and His Expectations (1749), part 1, 8.
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The ‘Doctrine of Uniformity’ in Geology, as held by many of the most eminent of British Geologists, assumes that the earth’s surface and upper crust have been nearly as they are at present in temperature, and other physical qualities, during millions of millions of years. But the heat which we know, by observation, to be now conducted out of the earth yearly is so great, that if this action has been going on with any approach to uniformity for 20,000 million years, the amount of heat lost out of the earth would have been about as much as would heat, by 100 Cent., a quantity of ordinary surface rock of 100 times the earth’s bulk. This would be more than enough to melt a mass of surface rock equal in bulk to the whole earth. No hypothesis as to chemical action, internal fluidity, effects of pressure at great depth, or possible character of substances in the interior of the earth, possessing the smallest vestige of probability, can justify the supposition that the earth’s upper crust has remained nearly as it is, while from the whole, or from any part, of the earth, so great a quantity of heat has been lost.
In 'The “Doctrine of Uniformity” in Geology Briefly Refuted' (1866), Popular Lectures and Addresses (1891), Vol. 2, 6-7.
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Theory and fact are equally strong and utterly interdependent; one has no meaning without the other. We need theory to organize and interpret facts, even to know what we can or might observe. And we need facts to validate theories and give them substance.
Leonardo's Mountain of Clams and the Diet of Worms: Essays on Natural History (1998), 155.
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There are few substances to which it [iron] yields in interest, when it is considered how very intimately the knowledge and properties and uses is connected with human civilization.
In A Manual of Elementary Chemistry, Theoretical and Practical (1858), 310.
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There are living systems; there is no living “matter.” No substance, no single molecule, extracted and isolated from a living being possess, of its own, the aforementioned paradoxical properties. They are present in living systems only; that is to say, nowhere below the level of the cell.
Inaugural lecture on taking the chair of molecular biology, Collège de France (3 Nov 1967). From Biology to Ethics (1969), 5.
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There are, I believe, very few maxims in philosophy that have laid firmer hold upon the mind, than that air, meaning atmospherical air (free from various foreign matters, which were always supposed to be dissolved, and intermixed with it) is a simple elementary substance, indestructible, and unalterable, at least as much so as water is supposed to be. In the course of my enquiries, I was, however, soon satisfied that atmospherical air is not an unalterable thing; for that the phlogiston with which it becomes loaded from bodies burning in it, and animals breathing it, and various other chemical processes, so far alters and depraves it, as to render it altogether unfit for inflammation, respiration, and other purposes to which it is subservient; and I had discovered that agitation in water, the process of vegetation, and probably other natural processes, by taking out the superfluous phlogiston, restore it to its original purity.
'On Dephlogisticated Air, and the Constitution of the Atmosphere', in The Discovery of Oxygen, Part I, Experiments by Joseph Priestley 1775 (Alembic Club Reprint, 1894), 6.
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There is deposited in them [plants] an enormous quantity of potential energy [Spannkräfte], whose equivalent is provided to us as heat in the burning of plant substances. So far as we know at present, the only living energy [lebendige Kraft] absorbed during plant growth are the chemical rays of sunlight… Animals take up oxygen and complex oxidizable compounds made by plants, release largely as combustion products carbonic acid and water, partly as simpler reduced compounds, thus using a certain amount of chemical potential energy to produce heat and mechanical forces. Since the latter represent a relatively small amount of work in relation to the quantity of heat, the question of the conservation of energy reduces itself roughly to whether the combustion and transformation of the nutritional components yields the same amount of heat released by animals.
Wissenschaftliche Abhandlungen (1847), 66. Trans. Joseph S. Fruton, Proteins, Enzymes, Genes: The Interplay of Chemistry and Biology (1999), 247.
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There is more evidence to prove that saltiness [of the sea] is due to the admixture of some substance ... It is this stuff which makes salt water heavy (it weighs more than fresh water) and thick. The difference in consistency is such that ships with the same cargo very nearly sink in a river when they are quite fit to navigate in the sea. This circumstance has before now caused loss to shippers freighting their ships in a river. That the thicker consistency is due to an admixture of something is proved by the fact that if you make strong brine by the admixture of salt, eggs, even when they are full, float in it. It almost becomes like mud; such a quantity of earthy matter is there in the sea.
[Aristotle recognised the different density of fresh (river) or salty (sea) water. He describes an experiment using an egg (which sinks in fresh water) that floats in a strong brine solution.]
Aristotle
Meteorology (350 B.C.), Book II, translated by E. W. Webster. Internet Classics Archive, (classics.mit.edu).
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There is more evidence to prove that saltness [of the sea] is due to the admixture of some substance, besides that which we have adduced. Make a vessel of wax and put it in the sea, fastening its mouth in such a way as to prevent any water getting in. Then the water that percolates through the wax sides of the vessel is sweet, the earthy stuff, the admixture of which makes the water salt, being separated off as it were by a filter.
[This is an example of Aristotle giving proof by experiment, in this case, of desalination by osmosis.]
Aristotle
Meteorology (350 B.C.), Book II, translated by E. W. Webster. Internet Classics Archive, (classics.mit.edu).
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There is only one subject matter for education, and that is Life in all its manifestations. Instead of this single unity, we offer children—Algebra, from which nothing follows; Geometry, from which nothing follows; Science, from which nothing follows; History, from which nothing follows; a Couple of Languages, never mastered; and lastly, most dreary of all, Literature, represented by plays of Shakespeare, with philological notes and short analyses of plot and character to be in substance committed to memory.
In 'The Aims of Education', The Aims of Education: & Other Essays (1917), 10.
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There must be some bond of union between mass and the chemical elements; and as the mass of a substance is ultimately expressed (although not absolutely, but only relatively) in the atom, a functional dependence should exist and be discoverable between the individual properties of the elements and their atomic weights. But nothing, from mushrooms to a scientific dependence can be discovered without looking and trying. So I began to look about and write down the elements with their atomic weights and typical properties, analogous elements and like atomic weights on separate cards, and soon this convinced me that the properties of the elements are in periodic dependence upon their atomic weights; and although I had my doubts about some obscure points, yet I have never doubted the universality of this law, because it could not possibly be the result of chance.
Principles of Chemistry (1905), Vol. 2, 18.
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These facts shaw that mitosis is due to the co-ordinate play of an extremely complex system of forces which are as yet scarcely comprehended. Its purpose is, however, as obvious as its physiological explanation is difficult. It is the end of mitosis to divide every part of the chromatin of the mother-cell equally between the daughter-nuclei. All the other operations are tributary to this. We may therefore regard the mitotic figure as essentially an apparatus for the distribution of the hereditary substance, and in this sense as the especial instrument of inheritance.
The Cell in Development and Inheritance (1896), 86.
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These principles have given me a way of explaining naturally the union or rather the mutual agreement [conformité] of the soul and the organic body. The soul follows its own laws, and the body likewise follows its own laws; and they agree with each other in virtue of the pre-established harmony between all substances, since they are all representations of one and the same universe.
The Monadology and Other Philosophical Writings (1714), trans. Robert Latta (1898), 262.
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This Academy [at Lagado] is not an entire single Building, but a Continuation of several Houses on both Sides of a Street; which growing waste, was purchased and applied to that Use.
I was received very kindly by the Warden, and went for many Days to the Academy. Every Room hath in it ' one or more Projectors; and I believe I could not be in fewer than five Hundred Rooms.
The first Man I saw was of a meagre Aspect, with sooty Hands and Face, his Hair and Beard long, ragged and singed in several Places. His Clothes, Shirt, and Skin were all of the same Colour. He had been Eight Years upon a Project for extracting Sun-Beams out of Cucumbers, which were to be put into Vials hermetically sealed, and let out to warm the Air in raw inclement Summers. He told me, he did not doubt in Eight Years more, that he should be able to supply the Governor's Gardens with Sunshine at a reasonable Rate; but he complained that his Stock was low, and interested me to give him something as an Encouragement to Ingenuity, especially since this had been a very dear Season for Cucumbers. I made him a small Present, for my Lord had furnished me with Money on purpose, because he knew their Practice of begging from all who go to see them.
I saw another at work to calcine Ice into Gunpowder; who likewise shewed me a Treatise he had written concerning the Malleability of Fire, which he intended to publish.
There was a most ingenious Architect who had contrived a new Method for building Houses, by beginning at the Roof, and working downwards to the Foundation; which he justified to me by the life Practice of those two prudent Insects the Bee and the Spider.
In another Apartment I was highly pleased with a Projector, who had found a device of plowing the Ground with Hogs, to save the Charges of Plows, Cattle, and Labour. The Method is this: In an Acre of Ground you bury at six Inches Distance, and eight deep, a quantity of Acorns, Dates, Chestnuts, and other Masts or Vegetables whereof these Animals are fondest; then you drive six Hundred or more of them into the Field, where in a few Days they will root up the whole Ground in search of their Food, and make it fit for sowing, at the same time manuring it with their Dung. It is true, upon Experiment they found the Charge and Trouble very great, and they had little or no Crop. However, it is not doubted that this Invention may be capable of great Improvement.
I had hitherto seen only one Side of the Academy, the other being appropriated to the Advancers of speculative Learning.
Some were condensing Air into a dry tangible Substance, by extracting the Nitre, and letting the acqueous or fluid Particles percolate: Others softening Marble for Pillows and Pin-cushions. Another was, by a certain Composition of Gums, Minerals, and Vegetables outwardly applied, to prevent the Growth of Wool upon two young lambs; and he hoped in a reasonable Time to propagate the Breed of naked Sheep all over the Kingdom.
Gulliver's Travels (1726, Penguin ed. 1967), Part III, Chap. 5, 223.
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This frustration of reading the tabloid press… it would easy to become convinced that the human race is on a mission to divide things into two clean columns… Good or evil, healthy or deadly or natural or chemical… everything organic and natural is good, ignoring the fact that organic natural substances include arsenic… Everything chemical is bad, ignoring that fact the everything is chemicals. Everything is chemicals! The day they discover yoga mats are carcinogenic will be the happiest day of my life.
Introducing his song, 'The Fence', on DVD, Live at the Royal Albert Hall (2011).
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This investigation has yielded an unanticipated result that reaction of cyanic acid with ammonia gives urea, a noteworthy result in as much as it provides an example of the artificial production of an organic, indeed a so-called animal, substance from inorganic substances.
[The first report of the epoch-making discovery, that an organic compound can be produced from inorganic substances.]
In 'On the Artificial Formation of Urea'. In J.C. Poggendorff's Annalen der Physik und Chemie (1828), 88, 253. Alternate translation in 'Über Künstliche Bildung des Hamstoffs', Annalen der Physik und Chemie (1828), 12, 253, as translated in Quarterly Journal of Science (Apr-Jun 1828), 25, 491. Collected in Henry Marshall Leicester and Herbert S. Klickstein, A Source Book in Chemistry, 1400-1900 (1951), 310.
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This is the kingdom of the chemical elements, the substances from which everything tangible is made. It is not an extensive country, for it consists of only a hundred or so regions (as we shall often term the elements), yet it accounts for everything material in our actual world. From the hundred elements that are at the center of our story, all planets, rocks, vegetation, and animals are made. These elements are the basis of the air, the oceans, and the Earth itself. We stand on the elements, we eat the elements, we are the elements. Because our brains are made up of elements, even our opinions are, in a sense, properties of the elements and hence inhabitants of the kingdom.
In 'The Terrain', The Periodic Kingdom: A Journey Into the Land of the Chemical Elements (1995), 3.
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This is the right cavity of the two cavities of the heart. When the blood in this cavity has become thin, it must be transferred into the left cavity, where the pneuma is generated. But there is no passage between these two cavities, the substance of the heart there being impermeable. It neither contains a visible passage, as some people have thought, nor does it contain an invisible passage which would permit the passage of blood, as Galen thought. The pores of the heart there are compact and the substance of the heart is thick. It must, therefore, be that when the blood has become thin, it is passed into the arterial vein [pulmonary artery] to the lung, in order to be dispersed inside the substance of the lung, and to mix with the air. The finest parts of the blood are then strained, passing into the venous artery [pulmonary vein] reaching the left of the two cavities of the heart, after mixing with the air and becoming fit for the generation of pneuma.
Albert Z. Iskandar, 'Ibn al-Nafis', In Charles Coulston Gillispie (ed.), Dictionary of Scientific Biography (1974), Vol. 9, 603.
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Those who have handled sciences have been either men of experiment or men of dogmas. The men of experiment are like the ant; they only collect and use; the reasoners resemble spiders, who make cobwebs out of their own substance. But the bee takes a middle course; it gathers its material from the flowers of the garden and of the field, but transforms and digests it by a power of its own. Not unlike this is the true business of philosophy; for it neither relies solely or chiefly on the powers of the mind, nor does it take the matter which it gathers from natural history and mechanical experiments and lay it up in the memory whole, as it finds it; but lays it up in the understanding altered and digested. Therefore from a closer and purer league between these two faculties, the experimental and the rational (such as has never yet been made), much may be hoped.
From Novum Organum (1620), Book 1, Aphorism 95. Translated as The New Organon: Aphorisms Concerning the Interpretation of Nature and the Kingdom of Man), collected in James Spedding, Robert Ellis and Douglas Heath (eds.), The Works of Francis Bacon (1857), Vol. 4, 92-3.
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Through [the growing organism's] power of assimilation there is a constant encroachment of the organic upon the inorganic, a constant attempt to convert all available material into living substance, and to indefinitely multiply the total number of individual organisms.
In History of the Human Body (1919), 2.
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Thus it might be said, that the vegetable is only the sketch, nor rather the ground-work of the animal; that for the formation of the latter, it has only been requisite to clothe the former with an apparatus of external organs, by which it might be connected with external objects.
From hence it follows, that the functions of the animal are of two very different classes. By the one (which is composed of an habitual succession of assimilation and excretion) it lives within itself, transforms into its proper substance the particles of other bodies, and afterwards rejects them when they are become heterogeneous to its nature. By the other, it lives externally, is the inhabitant of the world, and not as the vegetable of a spot only; it feels, it perceives, it reflects on its sensations, it moves according to their influence, and frequently is enabled to communicate by its voice its desires, and its fears, its pleasures, and its pains.
The aggregate of the functions of the first order, I shall name the organic life, because all organized beings, whether animal or vegetable, enjoy it more or less, because organic texture is the sole condition necessary to its existence. The sum of the functions of the second class, because it is exclusively the property of the animal, I shall denominate the animal life.
Physiological Researches on Life and Death (1815), trans. P. Gold, 22-3.
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Thus the radio elements formed strange and cruel families in which each member was created by spontaneous transformation of the mother substance: radium was a “descendant” of uranium, polonium a descendant of radium.
Eve Curie
In Eve Curie, Madame Curie: a Biography by Eve Curie (1937, 2007), 197.
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To take one of the simplest cases of the dissipation of energy, the conduction of heat through a solid—consider a bar of metal warmer at one end than the other and left to itself. To avoid all needless complication, of taking loss or gain of heat into account, imagine the bar to be varnished with a substance impermeable to heat. For the sake of definiteness, imagine the bar to be first given with one half of it at one uniform temperature, and the other half of it at another uniform temperature. Instantly a diffusing of heat commences, and the distribution of temperature becomes continuously less and less unequal, tending to perfect uniformity, but never in any finite time attaining perfectly to this ultimate condition. This process of diffusion could be perfectly prevented by an army of Maxwell’s ‘intelligent demons’* stationed at the surface, or interface as we may call it with Prof. James Thomson, separating the hot from the cold part of the bar.
* The definition of a ‘demon’, according to the use of this word by Maxwell, is an intelligent being endowed with free will, and fine enough tactile and perceptive organisation to give him the faculty of observing and influencing individual molecules of matter.
In 'The Kinetic Theory of the Dissipation of Energy', Nature (1874), 9, 442.
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