[The chemical bond] First, it is related to the disposition of two electrons (remember, no one has ever seen an electron!): next, these electrons have their spins pointing in opposite directions (remember, no one can ever measure the spin of a particular electron!): then, the spatial distribution of these electrons is described analytically with some degree of precision (remember, there is no way of distinguishing experimentally the density distribution of one electron from another!): concepts like hybridization, covalent and ionic structures, resonance, all appear, not one of which corresponds to anything that is directly measurable. These concepts make a chemical bond seem so real, so life-like, that I can almost see it. Then I wake with a shock to the realization that a chemical bond does not exist; it is a figment of the imagination that we have invented, and no more real than the square root of - 1. I will not say that the known is explained in terms of the unknown, for that is to misconstrue the sense of intellectual adventure. There is no explanation: there is form: there is structure: there is symmetry: there is growth: and there is therefore change and life.

An amino acid residue (other than glycine) has no symmetry elements. The general operation of conversion of one residue of a single chain into a second residue equivalent to the first is accordingly a rotation about an axis accompanied by translation along the axis. Hence the only configurations for a chain compatible with our postulate of equivalence of the residues are helical configurations.
[Co-author with American chemist, ert B. Corey (1897-1971) and H. R. Branson]

Are the atoms of the dextroacid (tartaric) grouped in the spirals of a right-hand helix or situated at the angles of an irregular tetrahedron, or arranged in such or such particular unsymmetrical fashion? We are unable to reply to these questions. But there can be no reason for doubting that the grouping of the atoms has an unsymmetrical arrangement with a non-superimposable image. It is not less certain that the atoms of the laevo-acid realize precisely an unsymmetrical arrangement of the inverse of the above.

Every chemical substance, whether natural or artificial, falls into one of two major categories, according to the spatial characteristic of its form. The distinction is between those substances that have a plane of symmetry and those that do not. The former belong to the mineral, the latter to the living world.

Guided only by their feeling for symmetry, simplicity, and generality, and an indefinable sense of the fitness of things, creative mathematicians now, as in the past, are inspired by the art of mathematics rather than by any prospect of ultimate usefulness.

I did some very technical work in partial differential equations, made an unsuccessful pass at shock waves, worked in scale invariant variational problems, made a poor stab at three manifold topology, learned gauge field theory and then some about applications to four manifolds, and have recently been working in equations with algebraic infinite symmetries. I find that I am bored with anything I understand. My excuse is that I am too poor an expositor to want to spend time on formal matters.

I suppose that I tend to be optimistic about the future of physics. And nothing makes me more optimistic than the discovery of broken symmetries. In the seventh book of the Republic, Plato describes prisoners who are chained in a cave and can see only shadows that things outside cast on the cave wall. When released from the cave at first their eyes hurt, and for a while they think that the shadows they saw in the cave are more real than the objects they now see. But eventually their vision clears, and they can understand how beautiful the real world is. We are in such a cave, imprisoned by the limitations on the sorts of experiments we can do. In particular, we can study matter only at relatively low temperatures, where symmetries are likely to be spontaneously broken, so that nature does not appear very simple or unified. We have not been able to get out of this cave, but by looking long and hard at the shadows on the cave wall, we can at least make out the shapes of symmetries, which though broken, are exact principles governing all phenomena, expressions of the beauty of the world outside.

If the mysterious influence to which the dissymmetry of nature is due should come to change in sense or direction, the constituting elements of all living beings would take an inverse dissymmetry. Perhaps a new world would be presented to us. Who could foresee the organization of living beings, if the cellulose, which is right, should become left, if the left albumen of the blood should become right? There are here mysteries which prepare immense labours for the future, and from this hour invite the most serious meditations in science.

In attempting to discover how much blood passes from the veins into the arteries I made dissections of living animals, opened up arteries in them, and carried out various other investigations. I also considered the symmetry and size of the ventricles of the heart and of the vessels which enter and leave them (since Nature, who does nothing purposelessly, would not purposelessly have given these vessels such relatively large size). I also recalled the elegant and carefully contrived valves and fibres and other structural artistry of the heart; and many other points. I considered rather often and with care all this evidence, and took correspondingly long trying to assess how much blood was transmitted and in how short a time. I also noted that the juice of the ingested food could not supply this amount without our having the veins, on the one hand, completely emptied and the arteries, on the other hand, brought to bursting through excessive inthrust of blood, unless the blood somehow flowed back again from the arteries into the veins and returned to the right ventricle of the heart. In consequence, I began privately to consider that it had a movement, as it were, in a circle.

In geometric and physical applications, it always turns out that a quantity is characterized not only by its tensor order, but also by symmetry.

It [mathematics] is in the inner world of pure thought, where all entia dwell, where is every type of order and manner of correlation and variety of relationship, it is in this infinite ensemble of eternal verities whence, if there be one cosmos or many of them, each derives its character and mode of being,—it is there that the spirit of mathesis has its home and its life.
Is it a restricted home, a narrow life, static and cold and grey with logic, without artistic interest, devoid of emotion and mood and sentiment? That world, it is true, is not a world of solar light, not clad in the colours that liven and glorify the things of sense, but it is an illuminated world, and over it all and everywhere throughout are hues and tints transcending sense, painted there by radiant pencils of psychic light, the light in which it lies. It is a silent world, and, nevertheless, in respect to the highest principle of art—the interpenetration of content and form, the perfect fusion of mode and meaning—it even surpasses music. In a sense, it is a static world, but so, too, are the worlds of the sculptor and the architect. The figures, however, which reason constructs and the mathematic vision beholds, transcend the temple and the statue, alike in simplicity and in intricacy, in delicacy and in grace, in symmetry and in poise. Not only are this home and this life thus rich in aesthetic interests, really controlled and sustained by motives of a sublimed and supersensuous art, but the religious aspiration, too, finds there, especially in the beautiful doctrine of invariants, the most perfect symbols of what it seeks—the changeless in the midst of change, abiding things hi a world of flux, configurations that remain the same despite the swirl and stress of countless hosts of curious transformations.

It is perhaps difficult for a modern student of Physics to realize the basic taboo of the past period (before 1956) … it was unthinkable that anyone would question the validity of symmetries under “space inversion,” “charge conjugation” and “time reversal.” It would have been almost sacrilegious to do experiments to test such unholy thoughts.

Leibnitz’s discoveries lay in the direction in which all modern progress in science lies, in establishing order, symmetry, and harmony, i.e., comprehensiveness and perspicuity,—rather than in dealing with single problems, in the solution of which followers soon attained greater dexterity than himself.

Like the furtive collectors of stolen art, we [cell biologists] are forced to be lonely admirers of spectacular architecture, exquisite symmetry, dramas of violence and death, mobility, self-sacrifice and, yes, rococo sex.

Mathematicians attach great importance to the elegance of their methods and their results. This is not pure dilettantism. What is it indeed that gives us the feeling of elegance in a solution, in a demonstration? It is the harmony of the diverse parts, their symmetry, their happy balance; in a word it is all that introduces order, all that gives unity, that permits us to see clearly and to comprehend at once both the ensemble and the details. But this is exactly what yields great results, in fact the more we see this aggregate clearly and at a single glance, the better we perceive its analogies with other neighboring objects, consequently the more chances we have of divining the possible generalizations. Elegance may produce the feeling of the unforeseen by the unexpected meeting of objects we are not accustomed to bring together; there again it is fruitful, since it thus unveils for us kinships before unrecognized. It is fruitful even when it results only from the contrast between the simplicity of the means and the complexity of the problem set; it makes us then think of the reason for this contrast and very often makes us see that chance is not the reason; that it is to be found in some unexpected law. In a word, the feeling of mathematical elegance is only the satisfaction due to any adaptation of the solution to the needs of our mind, and it is because of this very adaptation that this solution can be for us an instrument. Consequently this esthetic satisfaction is bound up with the economy of thought.

Mathematics has beauties of its own—a symmetry and proportion in its results, a lack of superfluity, an exact adaptation of means to ends, which is exceedingly remarkable and to be found only in the works of the greatest beauty. … When this subject is properly and concretely presented, the mental emotion should be that of enjoyment of beauty, not that of repulsion from the ugly and the unpleasant.

Maxwell's equations… originally consisted of eight equations. These equations are not “beautiful.” They do not possess much symmetry. In their original form, they are ugly. …However, when rewritten using time as the fourth dimension, this rather awkward set of eight equations collapses into a single tensor equation. This is what a physicist calls “beauty.”

Nature seems to take advantage of the simple mathematical representations of the symmetry laws. When one pauses to consider the elegance and the beautiful perfection of the mathematical reasoning involved and contrast it with the complex and far-reaching physical consequences, a deep sense of respect for the power of the symmetry laws never fails to develop.

Nothing in physics seems so hopeful to as the idea that it is possible for a theory to have a high degree of symmetry was hidden from us in everyday life. The physicist's task is to find this deeper symmetry.

Numbers … were his friends. In the simplest array of digits [Ramanujan] detected wonderful properties: congruences, symmetries and relationships which had escaped the notice of even the outstandingly gifted theoreticians.

Of possible quadruple algebras the one that had seemed to him by far the most beautiful and remarkable was practically identical with quaternions, and that he thought it most interesting that a calculus which so strongly appealed to the human mind by its intrinsic beauty and symmetry should prove to be especially adapted to the study of natural phenomena. The mind of man and that of Nature’s God must work in the same channels.

Our notion of symmetry is derived from the human face. Hence, we demand symmetry horizontally and in breadth only, not vertically nor in depth.

Since the beginning of physics, symmetry considerations have provided us with an extremely powerful and useful tool in our effort to understand nature. Gradually they have become the backbone of our theoretical formulation of physical laws.

Speaking about symmetry, look out our window, and you may see a cardinal attacking its reflection in the window. The cardinal is the only bird we have who often does this. If it has a nest nearby, the cardinal thinks there is another cardinal trying to invade its territory. It never realizes it is attacking its own reflection. Cardinals don’t know much about mirror symmetry!

Symmetry, as wide or as narrow as you may define its meaning, is one idea by which man through the ages has tried to comprehend and create order, beauty and perfection.

The artificial products do not have any molecular dissymmetry; and I could not indicate the existence of a more profound separation between the products born under the influence of life and all the others.

The chief forms of beauty are order and symmetry and definiteness, which the mathematical sciences demonstrate in a special degree.

The genius of Laplace was a perfect sledge hammer in bursting purely mathematical obstacles; but, like that useful instrument, it gave neither finish nor beauty to the results. In truth, in truism if the reader please, Laplace was neither Lagrange nor Euler, as every student is made to feel. The second is power and symmetry, the third power and simplicity; the first is power without either symmetry or simplicity. But, nevertheless, Laplace never attempted investigation of a subject without leaving upon it the marks of difficulties conquered: sometimes clumsily, sometimes indirectly, always without minuteness of design or arrangement of detail; but still, his end is obtained and the difficulty is conquered.

The mathematical sciences particularly exhibit order, symmetry, and limitation; and these are the greatest forms of the beautiful.

The order, the symmetry, the harmony enchant us ... God is pure order. He is the originator of universal harmony

The person who did most to give to analysis the generality and symmetry which are now its pride, was also the person who made mechanics analytical; I mean Euler.

The universe is a disymmetrical whole.

Then if the first argument remains secure (for nobody will produce a neater one, than the length of the periodic time is a measure of the size of the spheres), the order of the orbits follows this sequence, beginning from the highest: The first and highest of all is the sphere of the fixed stars, which contains itself and all things, and is therefore motionless. It is the location of the universe, to which the motion and position of all the remaining stars is referred. For though some consider that it also changes in some respect, we shall assign another cause for its appearing to do so in our deduction of the Earth’s motion. There follows Saturn, the first of the wandering stars, which completes its circuit in thirty years. After it comes Jupiter which moves in a twelve-year long revolution. Next is Mars, which goes round biennially. An annual revolution holds the fourth place, in which as we have said is contained the Earth along with the lunar sphere which is like an epicycle. In fifth place Venus returns every nine months. Lastly, Mercury holds the sixth place, making a circuit in the space of eighty days. In the middle of all is the seat of the Sun. For who in this most beautiful of temples would put this lamp in any other or better place than the one from which it can illuminate everything at the same time? Aptly indeed is he named by some the lantern of the universe, by others the mind, by others the ruler. Trismegistus called him the visible God, Sophocles' Electra, the watcher over all things. Thus indeed the Sun as if seated on a royal throne governs his household of Stars as they circle around him. Earth also is by no means cheated of the Moon’s attendance, but as Aristotle says in his book On Animals the Moon has the closest affinity with the Earth. Meanwhile the Earth conceives from the Sun, and is made pregnant with annual offspring. We find, then, in this arrangement the marvellous symmetry of the universe, and a sure linking together in harmony of the motion and size of the spheres, such as could be perceived in no other way. For here one may understand, by attentive observation, why Jupiter appears to have a larger progression and retrogression than Saturn, and smaller than Mars, and again why Venus has larger ones than Mercury; why such a doubling back appears more frequently in Saturn than in Jupiter, and still more rarely in Mars and Venus than in Mercury; and furthermore why Saturn, Jupiter and Mars are nearer to the Earth when in opposition than in the region of their occultation by the Sun and re-appearance. Indeed Mars in particular at the time when it is visible throughout the night seems to equal Jupiter in size, though marked out by its reddish colour; yet it is scarcely distinguishable among stars of the second magnitude, though recognized by those who track it with careful attention. All these phenomena proceed from the same course, which lies in the motion of the Earth. But the fact that none of these phenomena appears in the fixed stars shows their immense elevation, which makes even the circle of their annual motion, or apparent motion, vanish from our eyes.

Those who assert that the mathematical sciences make no affirmation about what is fair or good make a false assertion; for they do speak of these and frame demonstrations of them in the most eminent sense of the word. For if they do not actually employ these names, they do not exhibit even the results and the reasons of these, and therefore can be hardly said to make any assertion about them. Of what is fair, however, the most important species are order and symmetry, and that which is definite, which the mathematical sciences make manifest in a most eminent degree. And since, at least, these appear to be the causes of many things—now, I mean, for example, order, and that which is a definite thing, it is evident that they would assert, also, the existence of a cause of this description, and its subsistence after the same manner as that which is fair subsists in.

Thy shadow, Earth, from Pole to Central Sea,
Now steals along upon the Moon's meek shine
In even monochrome and curving line Of imperturbable serenity.
How shall I link such sun-cast symmetry
With the torn troubled form I know as thine,
That profile, placid as a brow divine,
With continents of moil and misery?

Truth … and if mine eyes
Can bear its blaze, and trace its symmetries,
Measure its distance, and its advent wait,
I am no prophet—I but calculate.

We called the new [fourth] quark the “charmed quark” because we were pleased, and fascinated by the symmetry it brought to the subnuclear world. “Charm” also means a “a magical device to avert evil,” and in 1970 it was realized that the old three quark theory ran into very serious problems. ... As if by magic the existence of the charmed quark would [solve those problems].

We have simply arrived too late in the history of the universe to see this primordial simplicity easily ... But although the symmetries are hidden from us, we can sense that they are latent in nature, governing everything about us. That's the most exciting idea I know: that nature is much simpler than it looks. Nothing makes me more hopeful that our generation of human beings may actually hold the key to the universe in our hands—that perhaps in our lifetimes we may be able to tell why all of what we see in this immense universe of galaxies and particles is logically inevitable.

What is it indeed that gives us the feeling of elegance in a solution, in a demonstration? It is the harmony of the diverse parts, their symmetry, their happy balance; in a word it is all that introduces order, all that gives unity, that permits us to see clearly and to comprehend at once both the ensemble and the details.

Whatever is Natural doth by that appear, adorned with all imaginable Elegance and Beauty. There are such inimitable gildings and embroideries in the smallest seeds of Plants, but especially in the parts of Animals, in the head or eye of a small Fly: such accurate order and symmetry in the frame of the most minute creatures, a Lowse or a Mite, as no man were able to conceive without seeing of them. Whereas the most curious works of Art, the sharpest finest Needle, doth appear as a blunt rough bar of iron, coming from the furnace or the forge. The most accurate engravings or embossments, seem such rude bungling deformed works, as if they had been done with a Mattock or a Trowel.

Wheeler’s First Moral Principle: Never make a calculation until you know the answer. Make an estimate before every calculation, try a simple physical argument (symmetry! invariance! conservation!) before every derivation, guess the answer to every paradox and puzzle. Courage: No one else needs to know what the guess is. Therefore make it quickly, by instinct. A right guess reinforces this instinct. A wrong guess brings the refreshment of surprise. In either case life as a spacetime expert, however long, is more fun!

When physicists speak of “beauty” in their theories, they really mean that their theory possesses at least two essential features: 1. A unifying symmetry 2. The ability to explain vast amounts of experimental data with the most economical mathematical expressions.

When the formulae of inorganic chemical compounds are considered, even a superficial observer is struck with the general symmetry of their construction; the compounds of nitrogen, phosphorus, antimony and arsenic especially exhibit the tendency of the elements to form compounds containing 3 or 5 equivs. of other elements, and it is in these proportions that their affinities are best satisfied; thus in the ternal group we have NO₃, NH₃, NI₃, NS₃, PO₃, PH₃, PCl₃, SbO₃, SbH₃, SbCl₃, AsO₃, AsH₃, AsCl₃ &c; and in the five-atom group NO₄, NH₄O, NH₄I, PO₅, PH₄I, &c. Without offering any hypothesis regarding the cause of this symmetrical grouping of atoms, it is sufficiently evident, from the examples just given, that such a tendency or law prevails, and that, no matter what the character of the uniting atoms may be, the combining power of the attracting element, if I may be allowed the term, is always satisfied by the same number of these atoms.

You boil it in sawdust: you salt it in glue:
You condense it with locusts and tape:
Still keeping one principal object in view—
To preserve its symmetrical shape.