… (T)he same cause, such as electricity, can simultaneously affect all sensory organs, since they are all sensitive to it; and yet, every sensory nerve reacts to it differently; one nerve perceives it as light, another hears its sound, another one smells it; another tastes the electricity, and another one feels it as pain and shock. One nerve perceives a luminous picture through mechanical irritation, another one hears it as buzzing, another one senses it as pain… He who feels compelled to consider the consequences of these facts cannot but realize that the specific sensibility of nerves for certain impressions is not enough, since all nerves are sensitive to the same cause but react to the same cause in different ways… (S)ensation is not the conduction of a quality or state of external bodies to consciousness, but the conduction of a quality or state of our nerves to consciousness, excited by an external cause.
Law of Specific Nerve Energies.

... I should think that anyone who considered it more reasonable for the whole universe to move in order to let the Earth remain fixed would be more irrational than one who should climb to the top of your cupola just to get a view of the city and its environs, and then demand that the whole countryside should revolve around him so that he would not have to take the trouble to turn his head.

...That day in the account of creation, or those days that are numbers according to its recurrence, are beyond the experience and knowledge of us mortal earthbound men. And if we are able to make any effort towards an understanding of those days, we ought not to rush forward with an ill considered opinion, as if no other reasonable and plausible interpretation could be offered.

...the remark attributed to Mrs. [Agatha] Christie that 'the older you get, the more interesting you become to an archaeologist,' was the creation of some pundit whose neck Mrs. Christie would be glad to wring if he would care to identify himself—she neither made the remark nor does she consider it particularly complimentary or amusing.

“That’s another thing we’ve learned from your Nation,” said Mein Herr, “map-making. But we’ve carried it much further than you. What do you consider the largest map that would be really useful?”
“About six inches to the mile.”
“Only six inches!” exclaimed Mein Herr. “We very soon got to six yards to the mile. Then we tried a hundred yards to the mile. And then came the grandest idea of all! We actually made a map of the country, on the scale of a mile to the mile!”
“Have you used it much?” I enquired.
“It has never been spread out, yet,” said Mein Herr: “the farmers objected: they said it would cover the whole country, and shut out the sunlight! So we now use the country itself, as its own map, and I assure you it does nearly as well.”

“Try another Subtraction sum. Take a bone from a dog: what remains?” [asked the Red Queen]
Alice considered. “The bone wouldn't remain, of course, if I took it—and the dog wouldn’t remain; it would come to bite me—and I’m sure I shouldn’t remain!”
“Then you think nothing would remain?” said the Red Queen.
“I think that’s the answer.”
“Wrong, as usual,” said the Red Queen, “the dog's temper would remain.”

[1665-09-03] Up, and put on my coloured suit on, very fine, and my new periwig, bought a good while since, but durst not wear, because the plague was in westminster when I bought it; and it is a wonder what will be the fashion after the plague is done as to periwigs, for nobody will dare to buy any haire for fear of the infection - that it had been cut off of heads of people dead of the plague. ... but Lord, to consider the madness of people of the town, who will (because they are forbid) come in crowds along with the dead corps to see them buried. ...

[An outsider views a scientist] as a type of unscrupulous opportunist: he appears as a realist, insofar as he seeks to describe the world independent of the act of perception; as idealist insofar as he looks upon the concepts and theories as the free inventions of the human spirit (not logically derivable from that which is empirically given); as positivist insofar as he considers his concepts and theories justified only to the extent to which they furnish a logical representation of relations among sense experiences. He may even appear as Platonist or Pythagorean insofar as he considers the viewpoint of logical simplicity as an indispensable and effective tool of his research.

[Beyond natural history] Other biological sciences take up the study at other levels of organization: dissecting the individual into organs and tissues and seeing how these work together, as in physiology; reaching down still further to the level of cells, as in cytology; and reaching the final biological level with the study of living molecules and their interactions, as in biochemistry. No one of these levels can be considered as more important than any other.

[Consider] a fence or gate erected across a road] The more modern type of reformer goes gaily up to it and says, “I don't see the use of this; let us clear it away.” To which the more intelligent type of reformer will do well to answer: “If you don't see the use of it, I certainly won't let you clear it away. Go away and think. Then, when you can come back and tell me that you do see the use of it, I may allow you to destroy it.”

[Howard] Aiken considered Babbage his intellectual “father.”

[In treating the sick], the first thing to consider is the provision of fresh air, clean water, and a healthy diet.

[It] is the little causes, long continued, which are considered as bringing about the greatest changes of the earth.

[King Hiero II] requested Archimedes to consider [whether a crown was pure gold or alloyed with silver]. The latter, while the case was still on his mind, happened to go to the bath, and on getting into a tub observed that the more his body sank into it the more water ran out over the tub. As this pointed out the way to explain the case in question, without a moment’s delay, and transported with joy, he jumped out of the tub and rushed home naked, crying with a loud voice that he had found what he was seeking; for as he ran he shouted repeatedly in Greek, “Eὕρηκα, εὕρηκα.”

[Relativist] Rel. There is a well-known proposition of Euclid which states that “Any two sides of a triangle are together greater than the third side.” Can either of you tell me whether nowadays there is good reason to believe that this proposition is true?
[Pure Mathematician] Math. For my part, I am quite unable to say whether the proposition is true or not. I can deduce it by trustworthy reasoning from certain other propositions or axioms, which are supposed to be still more elementary. If these axioms are true, the proposition is true; if the axioms are not true, the proposition is not true universally. Whether the axioms are true or not I cannot say, and it is outside my province to consider.

[The surplus of basic knowledge of the atomic nucleus was] largely used up [during the war with the atomic bomb as the dividend.] We must, without further delay restore this surplus in preparation for the important peacetime job for the nucleus - power production. ... Many of the proposed applications of atomic power - even for interplanetary rockets - seem to be within the realm of possibility provided the economic factor is ruled out completely, and the doubtful physical and chemical factors are weighted heavily on the optimistic side. ... The development of economic atomic power is not a simple extrapolation of knowledge gained during the bomb work. It is a new and difficult project to reach a satisfactory answer. Needless to say, it is vital that the atomic policy legislation now being considered by the congress recognizes the essential nature of this peacetime job, and that it not only permits but encourages the cooperative research-engineering effort of industrial, government and university laboratories for the task. ... We must learn how to generate the still higher energy particles of the cosmic rays - up to 1,000,000,000 volts, for they will unlock new domains in the nucleus.

[We] can easily distinguish what relates to Mathematics in any question from that which belongs to the other sciences. But as I considered the matter carefully it gradually came to light that all those matters only were referred to Mathematics in which order and measurements are investigated, and that it makes no difference whether it be in numbers, figures, stars, sounds or any other object that the question of measurement arises. I saw consequently that there must be some general science to explain that element as a whole which gives rise to problems about order and measurement, restricted as these are to no special subject matter. This, I perceived was called “Universal Mathematics,” not a far-fetched asignation, but one of long standing which has passed into current use, because in this science is contained everything on account of which the others are called parts of Mathematics.

Compounds formed by chemical attraction, possess new properties different from those of their component parts... chemists have long believed that the contrary took place in their combination. They thought, in fact, that the compounds possessed properties intermediate between those of their component parts; so that two bodies, very coloured, very sapid, or insapid, soluble or insoluble, fusible or infusible, fixed or volatile, assumed in chemical combination, a shade or colour, or taste, solubility or volatility, intermediate between, and in some sort composed of, the same properties which were considered in their principles. This is an illusion or error which modern chemistry is highly interested to overthrow.

Considerate la vostra semenza:
Fatti non foste a viver come bruti,
Ma per seguir virtute e conoscenza.
Consider your origins: you were not made to live as brutes, but to follow virtue and knowledge.

Dass die bis jetzt unzerlegten chemischen Elemente absolut unzerlegbare Stoffe seien, ist gegenwärtig mindestens sehr unwahrscheinlich. Vielmehr scheint es, dass die Atome der Elemente nicht die letzten, sondern nur die näheren Bestandtheile der Molekeln sowohl der Elemente wie der Verbindungen bilden, die Molekeln oder Molecule als Massentheile erster, die Atome als solche zweiter Ordnung anzusehen sind, die ihrerseits wiederum aus Massentheilchen einer dritten höheren Ordnung bestehen werden.
That the as yet undivided chemical elements are absolutely irreducible substances, is currently at least very unlikely. Rather it seems, that the atoms of elements are not the final, but only the immediate constituents of the molecules of both the elements and the compounds—the Molekeln or molecule as foremost division of matter, the atoms being considered as second order, in turn consisting of matter particles of a third higher order.
[Speculating in 1870, on the existence of subatomic particles, in opening remark of the paper by which he became established as co-discoverer of the Periodic Law.]

In primis, hominis est propria VERI inquisitio atque investigato. Itaque cum sumus negotiis necessariis, curisque vacui, tum avemus aliquid videre, audire, ac dicere, cognitionemque rerum, aut occultarum aut admirabilium, ad benè beatéque vivendum necessariam ducimus; —ex quo intelligitur, quod VERUM, simplex, sincerumque sit, id esse naturæ hominis aptissimum. Huic veri videndi cupiditati adjuncta est appetitio quædam principatûs, ut nemini parere animus benè a naturâ informatus velit, nisi præcipienti, aut docenti, aut utilitatis causâ justè et legitimè imperanti: ex quo animi magnitudo existit, et humanarum rerum contemtio.
Before all other things, man is distinguished by his pursuit and investigation of TRUTH. And hence, when free from needful business and cares, we delight to see, to hear, and to communicate, and consider a knowledge of many admirable and abstruse things necessary to the good conduct and happiness of our lives: whence it is clear that whatsoever is TRUE, simple, and direct, the same is most congenial to our nature as men. Closely allied with this earnest longing to see and know the truth, is a kind of dignified and princely sentiment which forbids a mind, naturally well constituted, to submit its faculties to any but those who announce it in precept or in doctrine, or to yield obedience to any orders but such as are at once just, lawful, and founded on utility. From this source spring greatness of mind and contempt of worldly advantages and troubles.

Question: Account for the delicate shades of colour sometimes seen on the inside of an oyster shell. State and explain the appearance presented when a beam of light falls upon a sheet of glass on which very fine equi-distant parallel lines have been scratched very close to one another.
Answer: The delicate shades are due to putrefaction; the colours always show best when the oyster has been a bad one. Hence they are considered a defect and are called chromatic aberration.
The scratches on the glass will arrange themselves in rings round the light, as any one may see at night in a tram car.

Une même expression, dont les géomètres avaient considéré les propriétés abstraites, … représente'aussi le mouvement de la lumière dans l’atmosphère, quelle détermine les lois de la diffusion de la chaleur dans la matière solide, et quelle entre dans toutes les questions principales de la théorie des probabilités.
The same expression whose abstract properties geometers had considered … represents as well the motion of light in the atmosphere, as it determines the laws of diffusion of heat in solid matter, and enters into all the chief problems of the theory of probability.

A line is not made up of points. … In the same way, time is not made up of parts considered as indivisible “nows.”
Part of Aristotle’s reply to Zeno's paradox concerning continuity.

A lodestone is a wonderful thing in very many experiments, and like living things. And one of its remarkable virtues in that which the ancients considered to be a living soul in the sky, in the globes and in the stars, in the sun and in the moon.

A mathematical theory is not to be considered complete until you have made it so clear that you can explain it to the first man whom you meet on the street.

A new era of ocean exploration can yield discoveries that will help inform everything from critical medical advances to sustainable forms of energy. Consider that AZT, an early treatment for HIV, is derived from a Caribbean reef sponge, or that a great deal of energy—from offshore wind, to OTEC (ocean thermal energy conservation), to wind and wave energy—is yet untapped in our oceans.

A nutritive centre, anatomically considered, is merely a cell, the nucleus of which is the permanent source of successive broods of young cells, which from time to time fill the cavity of their parent, and carrying with them the cell wall of the parent, pass off in certain directions, and under various forms, according to the texture or organ of which their parent forms a part.

A physician is obligated to consider more than a diseased organ, more than even the whole man—he must view the man in his world.

A scientific or technical study always consists of the following three steps:
1. One decides the objective.
2. One considers the method.
3. One evaluates the method in relation to the objective.

A volcano may be considered as a cannon of immense size.

A wealthy doctor who can help a poor man, and will not without a fee, has less sense of humanity than a poor ruffian who kills a rich man to supply his necessities. It is something monstrous to consider a man of a liberal education tearing out the bowels of a poor family by taking for a visit what would keep them a week.

A weird happening has occurred in the case of a lansquenet named Daniel Burghammer, of the squadron of Captain Burkhard Laymann Zu Liebenau, of the honorable Madrucci Regiment in Piadena, in Italy. When the same was on the point of going to bed one night he complained to his wife, to whom he had been married by the Church seven years ago, that he had great pains in his belly and felt something stirring therein. An hour thereafter he gave birth to a child, a girl. When his wife was made aware of this, she notified the occurrence at once. Thereupon he was examined and questioned. … He confessed on the spot that he was half man and half woman and that for more than seven years he had served as a soldier in Hungary and the Netherlands… . When he was born he was christened as a boy and given in baptism the name of Daniel… . He also stated that while in the Netherlands he only slept once with a Spaniard, and he became pregnant therefrom. This, however, he kept a secret unto himself and also from his wife, with whom he had for seven years lived in wedlock, but he had never been able to get her with child… . The aforesaid soldier is able to suckle the child with his right breast only and not at all on the left side, where he is a man. He has also the natural organs of a man for passing water. Both are well, the child is beautiful, and many towns have already wished to adopt it, which, however, has not as yet been arranged. All this has been set down and described by notaries. It is considered in Italy to be a great miracle, and is to be recorded in the chronicles. The couple, however, are to be divorced by the clergy.

About the year 1821, I undertook to superintend, for the Government, the construction of an engine for calculating and printing mathematical and astronomical tables. Early in the year 1833, a small portion of the machine was put together, and was found to perform its work with all the precision which had been anticipated. At that period circumstances, which I could not control, caused what I then considered a temporary suspension of its progress; and the Government, on whose decision the continuance or discontinuance of the work depended, have not yet communicated to me their wishes on the question.

After … the general experimental knowledge has been acquired, accompanied with just a sufficient amount of theory to connect it together…, it becomes possible to consider the theory by itself, as theory. The experimental facts then go out of sight, in a great measure, not because they are unimportant, but because … they are fundamental, and the foundations are always hidden from view in well-constructed buildings.

After a tremendous task has been begun in our time, first by Copernicus and then by many very learned mathematicians, and when the assertion that the earth moves can no longer be considered something new, would it not be much better to pull the wagon to its goal by our joint efforts, now that we have got it underway, and gradually, with powerful voices, to shout down the common herd, which really does not weigh arguments very carefully?

Always design a thing by considering it in its next larger context—a chair in a room, a room in a house, a house in an environment, an environment in a city plan.

Among the authorities it is generally agreed that the Earth is at rest in the middle of the universe, and they regard it as inconceivable and even ridiculous to hold the opposite opinion. However, if we consider it more closely the question will be seen to be still unsettled, and so decidedly not to be despised. For every apparent change in respect of position is due to motion of the object observed, or of the observer, or indeed to an unequal change of both.

An engineer, a physicist and a mathematician find themselves in an anecdote, indeed an anecdote quite similar to many that you have no doubt already heard.
After some observations and rough calculations the engineer realizes the situation and starts laughing.
A few minutes later the physicist understands too and chuckles to himself happily, as he now has enough experimental evidence to publish a paper.
This leaves the mathematician somewhat perplexed, as he had observed right away that he was the subject of an anecdote, and deduced quite rapidly the presence of humor from similar anecdotes, but considers this anecdote to be too trivial a corollary to be significant, let alone funny.

An Englishman, unless asleep, feels an invisible compulsion to be doing something, to consider time as of some importance. With us, according to custom and tradition, the charm of life consists in ease—ease from the absence of compulsion to do anything.

An Individual, whatever species it might be, is nothing in the Universe. A hundred, a thousand individuals are still nothing. The species are the only creatures of Nature, perpetual creatures, as old and as permanent as it. In order to judge it better, we no longer consider the species as a collection or as a series of similar individuals, but as a whole independent of number, independent of time, a whole always living, always the same, a whole which has been counted as one in the works of creation, and which, as a consequence, makes only a unity in Nature.

An old French geometer used to say that a mathematical theory was never to be considered complete till you had made it so clear that you could explain it to the first man you met in the street.

And if one look through a Prism upon a white Object encompassed with blackness or darkness, the reason of the Colours arising on the edges is much the same, as will appear to one that shall a little consider it. If a black Object be encompassed with a white one, the Colours which appear through the Prism are to be derived from the Light of the white one, spreading into the Regions of the black, and therefore they appear in a contrary order to that, when a white Object is surrounded with black. And the same is to be understood when an Object is viewed, whose parts are some of them less luminous than others. For in the borders of the more and less luminous Parts, Colours ought always by the same Principles to arise from the Excess of the Light of the more luminous, and to be of the same kind as if the darker parts were black, but yet to be more faint and dilute.

Animals, whom we have made our slaves, we do not like to consider our equal.

Anyone who considers arithmetical methods of producing random digits is, of course, in the state of sin. For, as has been pointed out several times, there is no such thing as a random number—there are only methods to produce random numbers, and a strict arithmetic procedure of course is not such a method.

Aristotle, in spite of his reputation, is full of absurdities. He says that children should be conceived in the Winter, when the wind is in the North, and that if people marry too young the children will be female. He tells us that the blood of females is blacker then that of males; that the pig is the only animal liable to measles; that an elephant suffering from insomnia should have its shoulders rubbed with salt, olive-oil, and warm water; that women have fewer teeth than men, and so on. Nevertheless, he is considered by the great majority of philosophers a paragon of wisdom.

Art is usually considered to be not of the highest quality if the desired object is exhibited in the midst of unnecessary lumber.

As an empiricist I continue to think of the conceptual scheme of science as a tool, ultimately, for predicting future experience in the light of past experience. Physical objects are conceptually imported into the situation as convenient intermediaries—not by definition in terms of experience, but simply as irreducible posits comparable, epistemologically, to the gods of Homer. For my part I do, qua lay physicist, believe in physical objects and not in Homer's gods; and I consider it a scientific error to believe otherwise. But in point of epistemological footing the physical objects and the gods differ only in degree and not in kind. Both sorts of entities enter our conception only as cultural posits. The myth of physical objects is epistemologically superior to most in that it has proved more efficacious than other myths as a device for working a manageable structure into the flux of experience.

As the ostensible effect of the heat … consists not in warming the surrounding bodies but in rendering the ice fluid, so, in the case of boiling, the heat absorbed does not warm surrounding bodies but converts the water into vapor. In both cases, considered as the cause of warmth, we do not perceive its presence: it is concealed, or latent, and I gave it the name of “latent heat.”

As to the position of the earth, then, this is the view which some advance, and the views advanced concerning its rest or motion are similar. For here too there is no general agreement. All who deny that the earth lies at the centre think that it revolves about the centre, and not the earth only but, as we said before, the counter-earth as well. Some of them even consider it possible that there are several bodies so moving, which are invisible to us owing to the interposition of the earth. This, they say, accounts for the fact that eclipses of the moon are more frequent than eclipses of the sun; for in addition to the earth each of these moving bodies can obstruct it.

As we consider the manifold materials that keep us going between breakfast and bedtime, our welfare is served by the wild species that make up the planetary ecosystem with us. To date, scientists have conducted intensive screening of less than 1 percent of all species with a view to determining their economic potential. Yet these preliminary investigations have thrown up thousands of products of everyday use.

As yet, if a man has no feeling for art he is considered narrow-minded, but if he has no feeling for science this is considered quite normal. This is a fundamental weakness.

Astronomy, as the science of cyclical motions, has nothing in common with Geology. But look at Astronomy where she has an analogy with Geology; consider our knowledge of the heavens as a palaetiological science;—as the study of a past condition, from which the present is derived by causes acting in time. Is there no evidence of a beginning, or of a progress?

At the age of eleven, I began Euclid, with my brother as my tutor. ... I had not imagined that there was anything so delicious in the world. After I had learned the fifth proposition, my brother told me that it was generally considered difficult, but I had found no difficulty whatsoever. This was the first time it had dawned on me that I might have some intelligence.

Before his [Sir Astley Cooper’s] time, operations were too often frightful alternatives or hazardous compromises; and they were not seldom considered rather as the resource of despair than as a means of remedy; he always made them follow, as it were, in the natural course of treatment; he gave them a scientific character; and he moreover, succeeded, in a great degree, in divesting them of their terrors, by performing them unostentatiously, simply, confidently, and cheerfully, and thereby inspiring the patient with hope of relief, where previously resignation under misfortune had too often been all that could be expected from the sufferer.

Being also in accord with Goethe that discoveries are made by the age and not by the individual, I should consider the instances to be exceedingly rare of men who can be said to be living before their age, and to be the repository of knowledge quite foreign to the thought of the time. The rule is that a number of persons are employed at a particular piece of work, but one being a few steps in advance of the others is able to crown the edifice with his name, or, having the ability to generalise already known facts, may become in time to be regarded as their originator. Therefore it is that one name is remembered whilst those of coequals have long been buried in obscurity.

But from the time I was in college I learned that there is nothing one could imagine which is so strange and incredible that it was not said by some philosopher; and since that time, I have recognized through my travels that all those whose views are different from our own are not necessarily, for that reason, barbarians or savages, but that many of them use their reason either as much as or even more than we do. I also considered how the same person, with the same mind, who was brought up from infancy either among the French or the Germans, becomes different from what they would have been if they had always lived among the Chinese or among the cannibals, and how, even in our clothes fashions, the very thing that we liked ten years ago, and that we may like again within the next ten years, appears extravagant and ridiculous to us today. Thus our convictions result from custom and example very much more than from any knowledge that is certain... truths will be discovered by an individual rather than a whole people.

But having considered everything which has been said, one could by this believe that the earth and not the heavens is so moved, and there is no evidence to the contrary. Nevertheless, this seems prima facie as much, or more, against natural reason as are all or several articles of our faith. Thus, that which I have said by way of diversion (esbatement) in this manner can be valuable to refute and check those who would impugn our faith by argument.

But here it may be objected, that the present Earth looks like a heap of Rubbish and Ruines; And that there are no greater examples of confusion in Nature than Mountains singly or jointly considered; and that there appear not the least footsteps of any Art or Counsel either in the Figure and Shape, or Order and Disposition of Mountains and Rocks. Wherefore it is not likely they came so out of God's hands ... To which I answer, That the present face of the Earth with all its Mountains and Hills, its Promontaries and Rocks, as rude and deformed as they appear, seems to me a very beautiful and pleasant object, and with all the variety of Hills, and Valleys, and Inequalities far more grateful to behold, than a perfectly level Countrey without any rising or protuberancy, to terminate the sight: As anyone that hath but seen the Isle of Ely, or any the like Countrey must need acknowledge.

But if the heavens are moved by a daily movement, it is necessary to assume in the principal bodies of the universe and in the heavens two ways of movement which are contrary to each other: one from east to west and the other from west to east, as has often been said. And with this, it is proper to assume an excessively great speed, for anyone who reckons and considers well the height of distance of the heavens and the magnitude of these and of their circuit, if such a circuit were made in a day, could not imagine or conceive how marvelously and excessively swift would be the movement of the heavens, and how unbelievable and unthinkable.

But if you have seen the soil of India with your own eyes and meditate on its nature - if you consider the rounded stones found in the earth however deeply you dig, stones that are huge near the mountains and where the rivers have a violent current; stones that are of smaller size at greater distance from the mountains, and where the streams flow more slowly; stones that appear pulverised in the shape of sand where the streams begin to stagnate near their mouths and near the sea - if you consider all this, you could scarcely help thinking that India has once been a sea which by degrees has been filled up by the alluvium of the streams.

But the World being once fram’d, and the course of Nature establish’d, the Naturalist, (except in some few cases, where God, or Incorporeal Agents interpose), has recourse to the first Cause but for its general and ordinary Support and Influence, whereby it preserves Matter and Motion from Annihilation or Desition; and in explicating particular phenomena, considers onely the Size, Shape, Motion, (or want of it) Texture, and the resulting Qualities and Attributes of the small particles of Matter.

But, as we consider the totality of similarly broad and fundamental aspects of life, we cannot defend division by two as a natural principle of objective order. Indeed, the ‘stuff’ of the universe often strikes our senses as complex and shaded continua, admittedly with faster and slower moments, and bigger and smaller steps, along the way. Nature does not dictate dualities, trinities, quarterings, or any ‘objective’ basis for human taxonomies; most of our chosen schemes, and our designated numbers of categories, record human choices from a cornucopia of possibilities offered by natural variation from place to place, and permitted by the flexibility of our mental capacities. How many seasons (if we wish to divide by seasons at all) does a year contain? How many stages shall we recognize in a human life?

By destroying the biological character of phenomena, the use of averages in physiology and medicine usually gives only apparent accuracy to the results. From our point of view, we may distinguish between several kinds of averages: physical averages, chemical averages and physiological and pathological averages. If, for instance, we observe the number of pulsations and the degree of blood pressure by means of the oscillations of a manometer throughout one day, and if we take the average of all our figures to get the true or average blood pressure and to learn the true or average number of pulsations, we shall simply have wrong numbers. In fact, the pulse decreases in number and intensity when we are fasting and increases during digestion or under different influences of movement and rest; all the biological characteristics of the phenomenon disappear in the average. Chemical averages are also often used. If we collect a man's urine during twenty-four hours and mix all this urine to analyze the average, we get an analysis of a urine which simply does not exist; for urine, when fasting, is different from urine during digestion. A startling instance of this kind was invented by a physiologist who took urine from a railroad station urinal where people of all nations passed, and who believed he could thus present an analysis of average European urine! Aside from physical and chemical, there are physiological averages, or what we might call average descriptions of phenomena, which are even more false. Let me assume that a physician collects a great many individual observations of a disease and that he makes an average description of symptoms observed in the individual cases; he will thus have a description that will never be matched in nature. So in physiology, we must never make average descriptions of experiments, because the true relations of phenomena disappear in the average; when dealing with complex and variable experiments, we must study their various circumstances, and then present our most perfect experiment as a type, which, however, still stands for true facts. In the cases just considered, averages must therefore be rejected, because they confuse, while aiming to unify, and distort while aiming to simplify. Averages are applicable only to reducing very slightly varying numerical data about clearly defined and absolutely simple cases.

By keenly confronting the enigmas that surround us, and by considering and analyzing the observations that I had made I ended up in the domain of mathematics.

Causality may be considered as a mode of perception by which we reduce our sense impressions to order.

Certainly, speaking for the United States of America, I pledge that, as we sign this treaty in an era of negotiation, we consider it only one step toward a greater goal: the control of nuclear weapons on earth and the reduction of the danger that hangs over all nations as long as those weapons are not controlled.

Chemistry affords two general methods of determining the constituent principles of bodies, the method of analysis, and that of synthesis. When, for instance, by combining water with alkohol, we form the species of liquor called, in commercial language, brandy or spirit of wine, we certainly have a right to conclude, that brandy, or spirit of wine, is composed of alkohol combined with water. We can produce the same result by the analytical method; and in general it ought to be considered as a principle in chemical science, never to rest satisfied without both these species of proofs. We have this advantage in the analysis of atmospherical air, being able both to decompound it, and to form it a new in the most satisfactory manner.

Clarity about the aims and problems of socialism is of greatest significance in our age of transition. Since, under present circumstances, free and unhindered discussion of these problems has come under a powerful taboo, I consider the foundation of this magazine to be an important public service.

Classification is now a pejorative statement. You know, these classifiers look like “dumb fools.” I’m a classifier. But I’d like to use a word that includes more than what people consider is encompassed by classification. It is more than that, and it’s something which can be called phenomenology.

Colour, Figure, Motion, Extension and the like, considered only so many Sensations in the Mind, are perfectly known, there being nothing in them which is not perceived. But if they are looked on as notes or Images, referred to Things or Archetypes existing without the Mind, then are we involved all in Scepticism.

Consider a cow. A cow doesn’t have the problem-solving skill of a chimpanzee, which has discovered how to get termites out of the ground by putting a stick into a hole. Evolution has developed the brain’s ability to solve puzzles, and at the same time has produced in our brain a pleasure of solving problems.

Consider now the Milky Way. Here also we see an innumerable dust, only the grains of this dust are no longer atoms but stars; these grains also move with great velocities, they act at a distance one upon another, but this action is so slight at great distances that their trajectories are rectilineal; nevertheless, from time to time, two of them may come near enough together to be deviated from their course, like a comet that passed too close to Jupiter. In a word, in the eyes of a giant, to whom our Suns were what our atoms are to us, the Milky Way would only look like a bubble of gas.

Consider the eighth category, which deals with stones. Wilkins divides them into the following classifications: ordinary (flint, gravel, slate); intermediate (marble, amber, coral); precious (pearl, opal); transparent (amethyst, sapphire); and insoluble (coal, clay, and arsenic). The ninth category is almost as alarming as the eighth. It reveals that metals can be imperfect (vermilion, quicksilver); artificial (bronze, brass); recremental (filings, rust); and natural (gold, tin, copper). The whale appears in the sixteenth category: it is a viviparous, oblong fish. These ambiguities, redundances, and deficiencies recall those attributed by Dr. Franz Kuhn to a certain Chinese encyclopedia entitled Celestial Emporium of Benevolent Knowledge. On those remote pages it is written that animals are divided into (a) those that belong to the Emperor, (b) embalmed ones, (c) those that are trained, (d) suckling pigs, (e) mermaids, (f) fabulous ones, (g) stray dogs, (h) those that are included in this classification, (i) those that tremble as if they were mad, (j) innumerable ones, (k) those drawn with a very fine camel's hair brush, (l) others, (m) those that have just broken a flower vase, (n) those that resemble flies from a distance.

Consider the hateful brew compounded with gleaming, deadly white lead whose fresh colour is like milk…. Over the victim’s jaws and in the grooves of the gums is plastered an astringent froth, and the furrow of the tongue turns rough on either side, and the depth of the throat grows somewhat dry, and from the pernicious venom follows a dry retching and hawking, for this affliction is severe; meanwhile his spirit sickens and he is worn out with mortal suffering. His body too grows chill, while sometimes his eyes behold strange illusions or else he drowses; nor can he bestir his limbs as heretofore, and he succumbs to the overmastering fatigue.

Consider the lilies of the field, how they grow; they toil not, neither do they spin.

Consider the plight of a scientist of my age. I graduated from the University of California at Berkeley in 1940. In the 41 years since then the amount of biological information has increased 16 fold; during these 4 decades my capacity to absorb new information has declined at an accelerating rate and now is at least 50% less than when I was a graduate student. If one defines ignorance as the ratio of what is available to be known to what is known, there seems no alternative to the conclusion that my ignorance is at least 25 times as extensive as it was when I got my bachelor’s degree. Although I am sure that my unfortunate condition comes as no surprise to my students and younger colleagues, I personally find it somewhat depressing. My depression is tempered, however, by the fact that all biologists, young or old, developing or senescing, face the same melancholy situation because of an interlocking set of circumstances.

Consider the very roots of our ability to discern truth. Above all (or perhaps I should say “underneath all”), common sense is what we depend on—that crazily elusive, ubiquitous faculty we all have to some degree or other. … If we apply common sense to itself over and over again, we wind up building a skyscraper. The ground floor of the structure is the ordinary common sense we all have, and the rules for building news floors are implicit in the ground floor itself. However, working it all out is a gigantic task, and the result is a structure that transcends mere common sense.

Considered as a mere question of physics, (and keeping all moral considerations entirely out of sight,) the appearance of man is a geological phenomenon of vast importance, indirectly modifying the whole surface of the earth, breaking in upon any supposition of zoological continuity, and utterly unaccounted for by what we have any right to call the laws of nature.

Considered from the standpoint of chemistry, living bodies appear to us as laboratories of chemical processes, for they undergo perpetual changes in their material substrate. They draw materials from the outside world and combine them with the mass of their liquid and solid parts.

Considered in its entirety, psychoanalysis won’t do. It is an end product, moreover, like a dinosaur or a zeppelin, no better theory can ever be erected on its ruins, which will remain for ever one of the saddest and strangest of all landmarks in the history of twentieth century thought.

Considering that, among all those who up to this time made discoveries in the sciences, it was the mathematicians alone who had been able to arrive at demonstrations—that is to say, at proofs certain and evident—I did not doubt that I should begin with the same truths that they have investigated, although I had looked for no other advantage from them than to accustom my mind to nourish itself upon truths and not to be satisfied with false reasons.

Courtship, properly understood, is the process whereby both the male and the female are brought into that state of sexual tumescence which is a more or less necessary condition for sexual intercourse. The play of courtship cannot, therefore, be considered to be definitely brought to an end by the ceremony of marriage; it may more properly be regarded as the natural preliminary to every act of coitus.

Curves that have no tangents are the rule. … Those who hear of curves without tangents, or of functions without derivatives, often think at first that Nature presents no such complications. … The contrary however is true. … Consider, for instance, one of the white flakes that are obtained by salting a solution of soap. At a distance its contour may appear sharply defined, but as we draw nearer its sharpness disappears. The eye can no longer draw a tangent at any point. … The use of a magnifying glass or microscope leaves us just as uncertain, for fresh irregularities appear every time we increase the magnification. … An essential characteristic of our flake … is that we suspect … that any scale involves details that absolutely prohibit the fixing of a tangent.

Dissection … teaches us that the body of man is made up of certain kinds of material, so differing from each other in optical and other physical characters and so built up together as to give the body certain structural features. Chemical examination further teaches us that these kinds of material are composed of various chemical substances, a large number of which have this characteristic that they possess a considerable amount of potential energy capable of being set free, rendered actual, by oxidation or some other chemical change. Thus the body as a whole may, from a chemical point of view, be considered as a mass of various chemical substances, representing altogether a considerable capital of potential energy.

Do experimental work but keep in mind that other investigators in the same field will consider your discoveries as less than one fourth as important as they seem to you.

Doctors have been exposed—you always will be exposed—to the attacks of those persons who consider their own undisciplined emotions more important than the world's most bitter agonies—the people who would limit and cripple and hamper research because they fear research may be accompanied by a little pain and suffering.

During a conversation with the writer in the last weeks of his life, Sylvester remarked as curious that notwithstanding he had always considered the bent of his mind to be rather analytical than geometrical, he found in nearly every case that the solution of an analytical problem turned upon some quite simple geometrical notion, and that he was never satisfied until he could present the argument in geometrical language.

Each nerve cell receives connections from other nerve cells at six sites called synapses. But here is an astonishing fact—there are about one million billion connections in the cortical sheet. If you were to count them, one connection (or synapse) per second, you would finish counting some thirty-two million years after you began. Another way of getting a feeling for the numbers of connections in this extraordinary structure is to consider that a large match-head’s worth of your brain contains about a billion connections. Notice that I only mention counting connections. If we consider how connections might be variously combined, the number would be hyperastronomical—on the order of ten followed by millions of zeros. (There are about ten followed by eighty zero’s worth of positively charged particles in the whole known universe!)

Employment, which Galen calls 'Nature's Physician,' is so essential to human happiness that indolence is justly considered as the mother of misery.

Equations are Expressions of Arithmetical Computation, and properly have no place in Geometry, except as far as Quantities truly Geometrical (that is, Lines, Surfaces, Solids, and Proportions) may be said to be some equal to others. Multiplications, Divisions, and such sort of Computations, are newly received into Geometry, and that unwarily, and contrary to the first Design of this Science. For whosoever considers the Construction of a Problem by a right Line and a Circle, found out by the first Geometricians, will easily perceive that Geometry was invented that we might expeditiously avoid, by drawing Lines, the Tediousness of Computation. Therefore these two Sciences ought not to be confounded. The Ancients did so industriously distinguish them from one another, that they never introduced Arithmetical Terms into Geometry. And the Moderns, by confounding both, have lost the Simplicity in which all the Elegance of Geometry consists. Wherefore that is Arithmetically more simple which is determined by the more simple Equation, but that is Geometrically more simple which is determined by the more simple drawing of Lines; and in Geometry, that ought to be reckoned best which is geometrically most simple.

Euclidean mathematics assumes the completeness and invariability of mathematical forms; these forms it describes with appropriate accuracy and enumerates their inherent and related properties with perfect clearness, order, and completeness, that is, Euclidean mathematics operates on forms after the manner that anatomy operates on the dead body and its members. On the other hand, the mathematics of variable magnitudes—function theory or analysis—considers mathematical forms in their genesis. By writing the equation of the parabola, we express its law of generation, the law according to which the variable point moves. The path, produced before the eyes of the student by a point moving in accordance to this law, is the parabola.
If, then, Euclidean mathematics treats space and number forms after the manner in which anatomy treats the dead body, modern mathematics deals, as it were, with the living body, with growing and changing forms, and thus furnishes an insight, not only into nature as she is and appears, but also into nature as she generates and creates,—reveals her transition steps and in so doing creates a mind for and understanding of the laws of becoming. Thus modern mathematics bears the same relation to Euclidean mathematics that physiology or biology … bears to anatomy.

Every discipline must be honored for reason other than its utility, otherwise it yields no enthusiasm for industry.
For both reasons, I consider mathematics the chief subject for the common school. No more highly honored exercise for the mind can be found; the buoyancy [Spannkraft] which it produces is even greater than that produced by the ancient languages, while its utility is unquestioned.

Every investigator must before all things look upon himself as one who is summoned to serve on a jury. He has only to consider how far the statement of the case is complete and clearly set forth by the evidence. Then he draws his conclusion and gives his vote, whether it be that his opinion coincides with that of the foreman or not.

Facts are of not much use, considered as facts. They bewilder by their number and their apparent incoherency. Let them be digested into theory, however, and brought into mutual harmony, and it is another matter.

Firefly meteorites blazed against a dark background, and sometimes the lightning was frighteningly brilliant. Like a boy, I gazed open-mouthed at the fireworks, and suddenly, before my eyes, something magical occurred. A greenish radiance poured from Earth directly up to the station, a radiance resembling gigantic phosphorescent organ pipes, whose ends were glowing crimson, and overlapped by waves of swirling green mist.
“Consider yourself very lucky, Vladimir,” I said to myself, “to have watched the northern lights.”

For books [Charles Darwin] had no respect, but merely considered them as tools to be worked with. … he would cut a heavy book in half, to make it more convenient to hold. He used to boast that he had made Lyell publish the second edition of one of his books in two volumes, instead of in one, by telling him how ho had been obliged to cut it in half. … his library was not ornamental, but was striking from being so evidently a working collection of books.

For chemistry is no science form’d à priori; ’tis no production of the human mind, framed by reasoning and deduction: it took its rise from a number of experiments casually made, without any expectation of what follow’d; and was only reduced into an art or system, by collecting and comparing the effects of such unpremeditated experiments, and observing the uniform tendency thereof. So far, then, as a number of experimenters agree to establish any undoubted truth; so far they may be consider'd as constituting the theory of chemistry.

For the little that one has reflected on the origin of our knowledge, it is easy to perceive that we can acquire it only by means of comparison. That which is absolutely incomparable is wholly incomprehensible. God is the only example that we could give here. He cannot be comprehended, because he cannot be compared. But all which is susceptible of comparison, everything that we can perceive by different aspects, all that we can consider relatively, can always be judged according to our knowledge.

For we may remark generally of our mathematical researches, that these auxiliary quantities, these long and difficult calculations into which we are often drawn, are almost always proofs that we have not in the beginning considered the objects themselves so thoroughly and directly as their nature requires, since all is abridged and simplified, as soon as we place ourselves in a right point of view.

Gentlemen and ladies, this is ordinary alcohol, sometimes called ethanol; it is found in all fermented beverages. As you well know, it is considered by many to be poisonous, a belief in which I do not concur. If we subtract from it one CH₂-group we arrive at this colorless liquid, which you see in this bottle. It is sometimes called methanol or wood alcohol. It is certainly more toxic than the ethanol we have just seen. Its formula is CH₃OH. If, from this, we subtract the CH₂-group, we arrive at a third colorless liquid, the final member of this homologous series. This compound is hydrogen hydroxide, best known as water. It is the most poisonous of all.

Geology has shared the fate of other infant sciences, in being for a while considered hostile to revealed religion; so like them, when fully understood, it will be found a potent and consistent auxiliary to it, exalting our conviction of the Power, and Wisdom, and Goodness of the Creator.

Go to the ant, thou sluggard; consider her ways, and be wise.

Going by railroad I do not consider as travelling at all; it is merely “being sent” to a place, and very little different from becoming a parcel.

He had read much, if one considers his long life; but his contemplation was much more than his reading. He was wont to say that if he had read as much as other men he should have known no more than other men.

He who can properly define and divide is to be considered a god.

He who thus considers things in their first growth and origin … will obtain the clearest view of them.

Heat may be considered, either in respect of its quantity, or of its intensity. Thus two lbs. of water, equally heated, must contain double the quantity that one of them does, though the thermometer applied to them separately, or together, stands at precisely the same point, because it requires double the time to heat two lbs. as it does to heat one.

Here are a few things to keep in mind the next time ants show up in the potato salad. The 8,800 known species of the family Formicidae make up from 10% to 15% of the world's animal biomass, the total weight of all fauna. They are the most dominant social insect in the world, found almost everywhere except in the polar regions. Ants turn more soil than earthworms; they prune, weed and police most of the earth’s carrion. Among the most gregarious of creatures, they are equipped with a sophisticated chemical communications system. To appreciate the strength and speed of this pesky invertebrate, consider that a leaf cutter the size of a man could run repeated four-minute miles while carrying 750 lbs. of potato salad.

His [Henry Cavendish’s] Theory of the Universe seems to have been, that it consisted solely of a multitude of objects which could be weighed, numbered, and measured; and the vocation to which he considered himself called was, to weigh, number and measure as many of those objects as his allotted three-score years and ten would permit. This conviction biased all his doings, alike his great scientific enterprises, and the petty details of his daily life.

His motion to the meeting of the Council of the Chemical Society:
That henceforth the absurd game of chemical noughts and crosses be tabu within the Society's precincts and that, following the practice of the Press in ending a correspondence, it be an instruction to the officers to give notice “That no further contributions to the mysteries of Polarity will be received, considered or printed by the Society.” His challenge was not accepted.

Hitherto, no rival hypothesis has been proposed as a substitute for the doctrine of transmutation; for 'independent creation,' as it is often termed, or the direct intervention of the Supreme Cause, must simply be considered as an avowal that we deem the question to lie beyond the domain of science.

How many and how curious problems concern the commonest of the sea-snails creeping over the wet sea-weed! In how many points of view may its history be considered! There are its origin and development, the mystery of its generation, the phenomena of its growth, all concerning each apparently insignificant individual; there is the history of the species, the value of its distinctive marks, the features which link it with the higher and lower creatures, the reason why it takes its stand where we place it in the scale of creation, the course of its distribution, the causes of its diffusion, its antiquity or novelty, the mystery (deepest of mysteries) of its first appearance, the changes of the outline of continents and of oceans which have taken place since its advent, and their influence on its own wanderings.

How much does your building weigh?
A question often used to challenge architects to consider how efficiently materials were used for the space enclosed.

However closely we may associate thought with the physical machinery of the brain, the connection is dropped as irrelevant as soon as we consider the fundamental property of thought—that it may be correct or incorrect. …that involves recognising a domain of the other type of law—laws which ought to be kept, but may be broken.

However, if we consider that all the characteristics which have been cited are only differences in degree of structure, may we not suppose that this special condition of organization of man has been gradually acquired at the close of a long period of time, with the aid of circumstances which have proved favorable? What a subject for reflection for those who have the courage to enter into it!

Hubble's observations suggested that there was a time, called the big bang, when the universe was infinitesimally small and infinitely dense. Under such conditions all the laws of science, and therefore all ability to predict the future, would break down. If there were events earlier than this time, then they could not affect what happens at the present time. Their existence can be ignored because it would have no observational consequences. One may say that time had a beginning at the big bang, in the sense that earlier times simply would not be defined. It should be emphasized that this beginning in time is very different from those that had been considered previously. In an unchanging universe a beginning in time is something that has to be imposed by some being outside the universe; there is no physical necessity for a beginning. One can imagine that God created the universe at literally any time in the past. On the other hand, if the universe is expanding, there may be physical reasons why there had to be a beginning. One could still imagine that God created the universe at the instant of the big bang, or even afterwards in just such a way as to make it look as though there had been a big bang, but it would be meaningless to suppose that it was created before the big bang. An expanding universe does not preclude a creator, but it does place limits on when he might have carried out his job!

I came to biochemistry through chemistry; I came to chemistry, partly by the labyrinthine routes that I have related, and partly through the youthful romantic notion that the natural sciences had something to do with nature. What I liked about chemistry was its clarity surrounded by darkness; what attracted me, slowly and hesitatingly, to biology was its darkness surrounded by the brightness of the givenness of nature, the holiness of life. And so I have always oscillated between the brightness of reality and the darkness of the unknowable. When Pascal speaks of God in hiding, Deus absconditus, we hear not only the profound existential thinker, but also the great searcher for the reality of the world. I consider this unquenchable resonance as the greatest gift that can be bestowed on a naturalist.

I consider [H. G. Wells], as a purely imaginative writer, to be deserving of very high praise, but our methods are entirely different. I have always made a point in my romances of basing my so-called inventions upon a groundwork of actual fact, and of using in their construction methods and materials which are not entirely without the pale of contemporary engineering skill and knowledge. ... The creations of Mr. Wells, on the other hand, belong unreservedly to an age and degree of scientific knowledge far removed from the present, though I will not say entirely beyond the limits of the possible.

I consider it extremely doubtful whether the happiness of the human race has been enhanced by the technical and industrial developments that followed in the wake of rapidly progressing natural science.

I consider it important, indeed urgently necessary, for intellectual workers to get together, both to protect their own economic status and, also, generally speaking, to secure their influence in the political field.

I consider that a man’s brain originally is like a little empty attic, and you have to stock it with such furniture as you choose. A fool takes in all the lumber of every sort that he comes across, so that the knowledge which might be useful to him gets crowded out, or at best is jumbled up with a lot of other things so that he has a difficulty in laying his hands upon it. Now the skilful workman is very careful indeed as to what he takes into his brain-attic. He will have nothing but the tools which may help him in doing his work, but of these he has a large assortment, and all in the most perfect order. It is a mistake to think that that little room has elastic walls and can distend to any extent. Depend upon it there comes a time when for every addition of knowledge you forget something that you knew before. It is of the highest importance, therefore, not to have useless facts elbowing out the useful ones.

I consider that I understand an equation when I can predict the properties of its solutions, without actually solving it.