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Who said: “Every body perseveres in its state of being at rest or of moving uniformly straight forward, except insofar as it is compelled to change its state by forces impressed.”
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Home > Category Index for Science Quotations > Category Index C > Category: Combination

Combination Quotes (69 quotes)

Combination does not produce though mergers and combinations are still the accepted panacea. In Big business there appears to be increasing aridity, bureaucracy, and stultifying sacrifice of initiative and above all fear.
Aphorism listed Frederick Seitz, The Cosmic Inventor: Reginald Aubrey Fessenden (1866-1932) (1999), 55, being Transactions of the American Philosophical Society, Held at Philadelphia For Promoting Useful Knowledge, Vol. 86, Pt. 6.
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Den förslags-mening: att olika element förenade med ett lika antal atomer af ett eller flere andra gemensamma element … och att likheten i krystallformen bestämmes helt och hĺllet af antalet af atomer, och icke af elementens.
[Mitscherlich Law of Isomerism] The same number of atoms combined in the same way produces the same crystalline form, and the same crystalline form is independent of the chemical nature of the atoms, and is determined only by their number and relative position.
Original Swedish from 'Om Förhĺllandet emellan chemiska sammansättningen och krystallformen hos Arseniksyrade och Phosphorsyrade Salter', Kungl. Svenska vetenskapsakademiens handlingar (1821), 4. In English as expressed later by James F.W. Johnston, 'Report on the Recent Progress and present State of Chemical Science', to Annual Meeting at Oxford (1832), collected in Report of the First and Second Meetings of the British Association for the Advancement of Science (1833), 422. A Google raw translation of the Swedish is: “The present proposal-sense: that various elements associated with an equal number of atoms of one or several other common elements … and that the similarity in: crystal shape is determined entirely by the number of atoms, and not by the elements.”
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A man in twenty-four hours converts as much as seven ounces of carbon into carbonic acid; a milch cow will convert seventy ounces, and a horse seventy-nine ounces, solely by the act of respiration. That is, the horse in twenty-four hours burns seventy-nine ounces of charcoal, or carbon, in his organs of respiration to supply his natural warmth in that time ..., not in a free state, but in a state of combination.
In A Course of Six Lectures on the Chemical History of a Candle (1861), 117.
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A pair of Siamese twins in Australia, surgically separated six months ago, has been sewn back together. Apparently, each of them could remember only half the combination to their locker.
In Napalm and Silly Putty (2002), 104.
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A patient pursuit of facts, and cautious combination and comparison of them, is the drudgery to which man is subjected by his Maker, if he wishes to attain sure knowledge.
In 'Productions Mineral, Vegetable and Animal', Notes on the State of Virginia (1787), 112.
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About eight days ago I discovered that sulfur in burning, far from losing weight, on the contrary, gains it; it is the same with phosphorus; this increase of weight arises from a prodigious quantity of air that is fixed during combustion and combines with the vapors. This discovery, which I have established by experiments, that I regard as decisive, has led me to think that what is observed in the combustion of sulfur and phosphorus may well take place in the case of all substances that gain in weight by combustion and calcination; and I am persuaded that the increase in weight of metallic calxes is due to the same cause... This discovery seems to me one of the most interesting that has been made since Stahl and since it is difficult not to disclose something inadvertently in conversation with friends that could lead to the truth I have thought it necessary to make the present deposit to the Secretary of the Academy to await the time I make my experiments public.
Sealed note deposited with the Secretary of the French Academy 1 Nov 1772. Oeuvres de Lavoisier, Correspondance, Fasc. II. 1770-75 (1957), 389-90. Adapted from translation by A. N. Meldrum, The Eighteenth-Century Revolution in Science (1930), 3.
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All things on the earth are the result of chemical combination. The operation by which the commingling of molecules and the interchange of atoms take place we can imitate in our laboratories; but in nature they proceed by slow degrees, and, in general, in our hands they are distinguished by suddenness of action. In nature chemical power is distributed over a long period of time, and the process of change is scarcely to be observed. By acts we concentrate chemical force, and expend it in producing a change which occupies but a few hours at most.
In chapter 'Chemical Forces', The Poetry of Science: Or, Studies of the Physical Phenomena of Nature (1848), 235-236. Charles Dicken used this quote, with his own sub-head of 'Relative Importance Of Time To Man And Nature', to conclude his review of the book, published in The Examiner (1848).
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As our own species is in the process of proving, one cannot have superior science and inferior morals. The combination is unstable and self-destroying.
Voices From the Sky: Previews of the Coming Space Age (1967), 156.
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Astronomy affords the most extensive example of the connection of physical sciences. In it are combined the sciences of number and quantity, or rest and motion. In it we perceive the operation of a force which is mixed up with everything that exists in the heavens or on earth; which pervades every atom, rules the motion of animate and inanimate beings, and is a sensible in the descent of the rain-drop as in the falls of Niagara; in the weight of the air, as in the periods of the moon.
On the Connexion of the Physical Sciences (1858), 1.
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Both social and biosocial factors are necessary to interpret crosscultural studies, with the general proviso that one’s research interest determines which elements, in what combinations, are significant for the provision of understanding.
…...
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But I think that in the repeated and almost entire changes of organic types in the successive formations of the earth—in the absence of mammalia in the older, and their very rare appearance (and then in forms entirely. unknown to us) in the newer secondary groups—in the diffusion of warm-blooded quadrupeds (frequently of unknown genera) through the older tertiary systems—in their great abundance (and frequently of known genera) in the upper portions of the same series—and, lastly, in the recent appearance of man on the surface of the earth (now universally admitted—in one word, from all these facts combined, we have a series of proofs the most emphatic and convincing,—that the existing order of nature is not the last of an uninterrupted succession of mere physical events derived from laws now in daily operation: but on the contrary, that the approach to the present system of things has been gradual, and that there has been a progressive development of organic structure subservient to the purposes of life.
'Address to the Geological Society, delivered on the Evening of the 18th of February 1831', Proceedings of the Geological Society (1834), 1, 305-6.
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Certain elements have the property of producing the same crystal form when in combination with an equal number of atoms of one or more common elements, and the elements, from his point of view, can be arranged in certain groups. For convenience I have called the elements belonging to the same group … isomorphous.
Originally published in 'Om Förhĺllandet emellan chemiska sammansättningen och krystallformen hos Arseniksyrade och Phosphorsyrade Salter', (On the Relation between the Chemical Composition and Crystal Form of Salts of Arsenic and Phosphoric Acids), Kungliga Svenska vetenskapsakademiens handlingar (1821), 4. In F. Szabadváry article on 'Eilhard Mitscherlich' in Charles Coulston Gillispie (ed.), Dictionary of Scientific Biography (1974), Vol. 9, 424; perhaps from J.R. Partington, A History of Chemistry, Vol. 4 (1964), 210.
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Chymia, or Alchemy and Spagyrism, is the art of resolving compound bodies into their principles and of combining these again.
Fundamenta Chymiae (1720). Trans. J. R. Partington, A History of Chemistry (1961), Vol. 2, 664.
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Combining in our survey then, the whole range of deposits from the most recent to the most ancient group, how striking a succession do they present:– so various yet so uniform–so vast yet so connected. In thus tracing back to the most remote periods in the physical history of our continents, one system of operations, as the means by which many complex formations have been successively produced, the mind becomes impressed with the singleness of nature's laws; and in this respect, at least, geology is hardly inferior in simplicity to astronomy.
The Silurian System (1839), 574.
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Each new machine or technique, in a sense, changes all existing machines and techniques, by permitting us to put them together into new combinations. The number of possible combinations rises exponentially as the number of new machines or techniques rises
Future Shock (1970).
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Edison was by far the most successful and, probably, the last exponent of the purely empirical method of investigation. Everything he achieved was the result of persistent trials and experiments often performed at random but always attesting extraordinary vigor and resource. Starting from a few known elements, he would make their combinations and permutations, tabulate them and run through the whole list, completing test after test with incredible rapidity until he obtained a clue. His mind was dominated by one idea, to leave no stone unturned, to exhaust every possibility.
As quoted in 'Tesla Says Edison Was an Empiricist', The New York Times (19 Oct 1931), 25.
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Either one or the other [analysis or synthesis] may be direct or indirect. The direct procedure is when the point of departure is known-direct synthesis in the elements of geometry. By combining at random simple truths with each other, more complicated ones are deduced from them. This is the method of discovery, the special method of inventions, contrary to popular opinion.
Ampčre gives this example drawn from geometry to illustrate his meaning for “direct synthesis” when deductions following from more simple, already-known theorems leads to a new discovery. In James R. Hofmann, André-Marie Ampčre (1996), 159. Cites Académie des Sciences Ampčre Archives, box 261.
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Engineering is the science and art of efficient dealing with materials and forces ... it involves the most economic design and execution ... assuring, when properly performed, the most advantageous combination of accuracy, safety, durability, speed, simplicity, efficiency, and economy possible for the conditions of design and service.
Coauthor with Frank W. Skinner, and H. E. Wessman
1933
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Every arsenate has its corresponding phosphate, composed according to the same proportions, combined with the same amount of water of crystallization, and endowed with the same physical properties: in fact, the two series of salts differ in no respect, except that the radical of the acid in one series in phosphorus, while in the other it is arsenic.
The experimental clue he used forming his law of isomerism. Originally published in 'Om Förhĺllandet emellan chemiska sammansättningen och krystallformen hos Arseniksyrade och Phosphorsyrade Salter', (On the Relation between the Chemical Composition and Crystal Form of Salts of Arsenic and Phosphoric Acids), Kungliga Svenska vetenskapsakademiens handlingar (1821), 4. Translation as shown in Joseph William Mellor, A Comprehensive Treatise on Inorganic and Theoretical Chemistry (1922), Vol. 1, 652. A very similar translation (“the same physical properties” is replaced with “nearly equal solubilities in water and acids”) is in F. Szabadváry article on 'Eilhard Mitscherlich' in Charles Coulston Gillispie (ed.), Dictionary of Scientific Biography (1974), Vol. 9, 424; perhaps from J.R. Partington, A History of Chemistry, Vol. 4 (1964), 210.
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Every discoverer of a new truth, or inventor of the method which evolves it, makes a dozen, perhaps fifty, useless combinations, experiments, or trials for one successful one. In the realm of electricity or of mechanics there is no objection to this. But when such rejected failures involve a torture of animals, sometimes fearful in its character, there is a distinct objection to it.
From 'Vivisection', an original paper in Surgical Anaesthesia: Addresses, and Other Papers (1894, 1900), 369-370.
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From a mathematical standpoint it is possible to have infinite space. In a mathematical sense space is manifoldness, or combinations of numbers. Physical space is known as the 3-dimension system. There is the 4-dimension system, the 10-dimension system.
As quoted in 'Electricity Will Keep The World From Freezing Up', New York Times (12 Nov 1911), SM4.
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I believe myself to possess a most singular combination of qualities exactly fitted to make me pre-eminently a discoverer of the hidden realities of nature… the belief has been forced upon me…
Firstly: Owing to some peculiarity in my nervous system, I have perceptions of some things, which no one else has… and intuitive perception of… things hidden from eyes, ears, & ordinary senses…
Secondly: my sense reasoning faculties;
Thirdly: my concentration faculty, by which I mean the power not only of throwing my whole energy & existence into whatever I choose, but also of bringing to bear on anyone subject or idea, a vast apparatus from all sorts of apparently irrelevant & extraneous sources…
Well, here I have written what most people would call a remarkably mad letter; & yet certainly one of the most logical, sober-minded, cool, pieces of composition, (I believe), that I ever framed.
Lovelace Papers, Bodleian Library, Oxford University, 42, folio 12 (6 Feb 1841). As quoted and cited in Dorothy Stein (ed.), 'This First Child of Mine', Ada: A Life and a Legacy (1985), 86.
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I will now direct the attention of scientists to a previously unnoticed cause which brings about the metamorphosis and decomposition phenomena which are usually called decay, putrefaction, rotting, fermentation and moldering. This cause is the ability possessed by a body engaged in decomposition or combination, i.e. in chemical action, to give rise in a body in contact with it the same ability to undergo the same change which it experiences itself.
Annalen der Pharmacie 1839, 30, 262. Trans. W. H. Brock.
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If atoms do, by chance, happen to combine themselves into so many shapes, why have they never combined together to form a house or a slipper? By the same token, why do we not believe that if innumerable letters of the Greek alphabet were poured all over the market-place they would eventually happen to form the text of the Iliad?
The Essays of Michel de Montaigne, Book 2, Chapter 12, 'Apology for Raymond Sebond', trans. M. A. Screech (1991), 612.
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If the world may be thought of as a certain definite quantity of force and as a certain definite number of centers of force—and every other representation remains indefinite and therefore useless—it follows that, in the great dice game of existence, it must pass through calculable number of combinations. In infinite time, every possible combination would at some time or another be realized; more: it would be realized an infinite number of times. And since between every combination and its next recurrence all other possible combinations would have to take place, and each of these combination conditions of the entire sequence of combinations in the same series, a circular movement of absolutely identical series is thus demonstrated: the world as a circular movement that has already repeated itself infinitely often and plays its game in infinitum. This conception is not simply a mechanistic conception; for if it were that, it would not condition an infinite recurrence of identical cases, but a final state. Because the world has not reached this, mechanistic theory must be considered an imperfect and merely provisional hypothesis.
The Will to Power (Notes written 1883-1888), book 4, no. 1066. Trans. W. Kaufmann and R. J. Hollingdale and ed. W. Kaufmann (1968), 549.
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In a library we are surrounded by many hundreds of dear friends, but they are imprisoned by an enchanter in these paper and leathern boxes; and though they know us, and have been waiting two, ten, or twenty centuries for us,—some of them,—and are eager to give us a sign and unbosom themselves, it is the law of their limbo that they must not speak until spoken to; and as the enchanter has dressed them, like battalions of infantry, in coat and jacket of one cut, by the thousand and ten thousand, your chance of hitting on the right one is to be computed by the arithmetical rule of Permutation and Combination,—not a choice out of three caskets, but out of half a million caskets, all alike.
In essay 'Books', collected in Society and Solitude (1870, 1871), 171
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In the beginning of the year 1800 the illustrious professor conceived the idea of forming a long column by piling up, in succession, a disc of copper, a disc of zinc, and a disc of wet cloth, with scrupulous attention to not changing this order. What could be expected beforehand from such a combination? Well, I do not hesitate to say, this apparently inert mass, this bizarre assembly, this pile of so many couples of unequal metals separated by a little liquid is, in the singularity of effect, the most marvellous instrument which men have yet invented, the telescope and the steam engine not excepted.
In François Arago, 'Bloge for Volta' (1831), Oeuvres Completes de François Arago (1854), Vol. 1, 219-20.
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In the hands of Science and indomitable energy, results the most gigantic and absorbing may be wrought out by skilful combinations of acknowledged data and the simplest means.
From Introduction to Lecture on the Pendulum-Experiments at Harton Pit (1855), iv. The quote comes from the printed Introduction in the published booklet, but was not part of the printed lecture itself. At the request of a “deputation of gentlemen of South Shields,” the printed version of the lecture was written “in extenso, from memory,” after the original talk was given on 24 Oct 1854 at South Shields, County Durham, England.
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In the vestibule of the Manchester Town Hall are placed two life-sized marble statues facing each other. One of these is that of John Dalton … the other that of James Prescott Joule. … Thus honour is done to Manchester’s two greatest sons—to Dalton, the founder of modern Chemistry and of the Atomic Theory, and the laws of chemical-combining proportions; to Joule, the founder of modern Physics and the discoverer of the Law of Conservation of Energy. The one gave to the world the final and satisfactory proof … that in every kind of chemical change no loss of matter occurs; the other proved that in all the varied modes of physical change, no loss of energy takes place.
In John Dalton and the Rise of Modern Chemistry (1895), 7.
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It has hitherto been a serious impediment to the progress of knowledge, that is in investigating the origin or causes of natural productions, recourse has generally been had to the examination, both by experiment and reasoning, of what might be rather than what is. The laws or processes of nature we have every reason to believe invariable. Their results from time to time vary, according to the combinations of influential circumstances; but the process remains the same. Like the poet or the painter, the chemist may, and no doubt often' does, create combinations which nature never produced; and the possibility of such and such processes giving rise to such and such results, is no proof whatever that they were ever in natural operation.
Considerations on Volcanoes (1825), 243.
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It is not by his mixing and choosing, but by the shapes of his colors, and the combination of those shapes, that we recognize the colorist. Color becomes significant only when it becomes form.
In Art (1958), 156.
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It is still false to conclude that man is nothing but the highest animal, or the most progressive product of organic evolution. He is also a fundamentally new sort of animal and one in which, although organic evolution continues on its way, a fundamentally new sort of evolution has also appeared. The basis of this new sort of evolution is a new sort of heredity, the inheritance of learning. This sort of heredity appears modestly in other mammals and even lower in the animal kingdom, but in man it has incomparably fuller development and it combines with man's other characteristics unique in degree with a result that cannot be considered unique only in degree but must also be considered unique in kind.
In The Meaning of Evolution: A Study of the History of Life and of its Significance for Man (1949), 286.
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Let us ... consider the ovum [egg] as a physical system. Its potentialities are prodigious and one's first impulse is to expect that such vast potentialities would find expression in complexity of structure. But what do we find? The substance is clouded with particles, but these can be centrifuged away leaving it optically structureless but still capable of development.... On the surface of the egg there is a fine membrane, below it fluid of high viscosity, next fluid of relatively low viscosity, and within this the nucleus, which in the resting stage is simply a bag of fluid enclosed in a delicate membrane.... The egg's simplicity is not that of a machine or a crystal, but that of a nebula. Gathered into it are units relatively simple but capable by their combinations of forming a vast number of dynamical systems...
As guest of honour, closing day address (Jun 1928), Sixth Colloid Symposium, Toronto, Canada, 'Living Matter', printed in Harry Boyer Weiser (ed.), Colloid Symposium Monograph (1928), Vol. 6, 15. Quoted in Joseph Needham, Chemical Embryology (1931), Vol. 1, 612-613.
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Nature is an endless combination and repetition of very few laws. She hums the old well-known air through innumerable variations.
Essays, Lectures and Orations (1851), 7.
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On foundations we believe in the reality of mathematics, but of course, when philosophers attack us with their paradoxes, we rush to hide behind formalism and say 'mathematics is just a combination of meaningless symbols,'... Finally we are left in peace to go back to our mathematics and do it as we have always done, with the feeling each mathematician has that he is working with something real. The sensation is probably an illusion, but it is very convenient.
'The Work of Nicholas Bourbaki'American Mathematical Monthly (1970), 77, 134. In Carl C. Gaither, Alma E. Cavazos-Gaither, Mathematically Speaking: a Dictionary of Quotations (), 194.
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Our atom of carbon enters the leaf, colliding with other innumerable (but here useless) molecules of nitrogen and oxygen. It adheres to a large and complicated molecule that activates it, and simultaneously receives the decisive message from the sky, in the flashing form of a packet of solar light; in an instant, like an insect caught by a spider, it is separated from its oxygen, combined with hydrogen and (one thinks) phosphous, and finally inserted in a chain, whether long or short does not matter, but it is the chain of life. All this happens swiftly, in silence, at the temperature and pressure of the atmosphere, and gratis: dear colleagues, when we learn to do likewise we will be sicut Deus [like God], and we will have also solved the problem of hunger in the world.
Levi Primo and Raymond Rosenthal (trans.), The Periodic Table (1975, 1984), 227-228. In this final section of his book, Levi imagines the life of a carbon atom. He calls this his first “literary dream”. It came to him at Auschwitz.
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Perhaps... some day the precision of the data will be brought so far that the mathematician will be able to calculate at his desk the outcome of any chemical combination, in the same way, so to speak, as he calculates the motions of celestial bodies.
Oeuvres (1862), Vol. 2, 550-1. Trans. John Heilbron, Weighing Imponderables and Other Quantitative Science around 1800 (1993), 14.
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Proposition VIII. When two Undulations, from different Origins, coincide either perfectly or very nearly in Direction, their joint effect is a Combination of the Motions belonging to each.
'On the Theory of Light and Colours' (read in 1801), Philosophical Transactions (1802), 92, 34.
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Science is a field which grows continuously with ever expanding frontiers. Further, it is truly international in scope. … Science is a collaborative effort. The combined results of several people working together is often much more effective than could be that of an individual scientist working alone.
From his second Nobel Prize Banquet speech (10 Dec 1972). In Wilhelm Odelberg (ed.), Les Prix Nobel en 1972 (1973).
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Science is feasible when the variables are few and can be enumerated; when their combinations are distinct and clear. We are tending toward the condition of science and aspiring to do it. The artist works out his own formulas; the interest of science lies in the art of making science.
In Moralités (1932). Reprinted in J. Matthews (ed.), Collected Works (1970). As cited in Robert Andrews (ed.), The Columbia Dictionary of Quotations (1993), 810.
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Science is simply the classification of the common knowledge of the common people. It is bringing together the things we all know and putting them together so we can use them. This is creation and finds its analogy in Nature, where the elements are combined in certain ways to give us fruits or flowers or grain.
In Elbert Hubbard (ed. and publ.), The Philistine (Dec 1907), 26, 10.
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Science is the Differential Calculus of the mind. Art the Integral Calculus; they may be beautiful when apart, but are greatest only when combined.
Quoted in The Complete Poems of Hugh MacDiarmid 1920-76 (1978), Vol. 2, 1360.
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Simple molecules combine to make powerful chemicals. Simple cells combine to make powerful life-forms. Simple electronics combine to make powerful computers. Logically, all things are created by a combination of simpler, less capable components. Therefore, a supreme being must be in our future, not our origin. What if “God” is the consciousness that will be created when enough of us are connected by the Internet?!!
Thoughts by character Dogbert in Dilbert cartoon strip (11 Feb 1996).
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Suppose a number of equal waves of water to move upon the surface of a stagnant lake, with a certain constant velocity, and to enter a narrow channel leading out of the lake. Suppose then another similar cause to have excited another equal series of waves, which arrive at the same time, with the first. Neither series of waves will destroy the other, but their effects will be combined: if they enter the channel in such a manner that the elevations of one series coincide with those of the other, they must together produce a series of greater joint elevations; but if the elevations of one series are so situated as to correspond to the depressions of the other, they must exactly fill up those depressions. And the surface of the water must remain smooth; at least I can discover no alternative, either from theory or from experiment.
A Reply to the Animadversions of the Edinburgh Reviewers on Some Papers Published in the Philosophical Transactions (1804), 17-8.
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Talent deals with the actual, with discovered and realized truths, any analyzing, arranging, combining, applying positive knowledge, and, in action, looking to precedents. Genius deals with the possible, creates new combinations, discovers new laws, and acts from an insight into new principles.
In 'Genius', Wellman’s Miscellany (Dec 1871), 4, No. 6, 203.
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The activity characteristic of professional engineering is the design of structures, machines, circuits, or processes, or of combinations of these elements into systems or plants and the analysis and prediction of their performance and costs under specified working conditions.
1954
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The chemists work with inaccurate and poor measuring services, but they employ very good materials. The physicists, on the other hand, use excellent methods and accurate instruments, but they apply these to very inferior materials. The physical chemists combine both these characteristics in that they apply imprecise methods to impure materials.
Quoted in Ralph Oesper, The Human Side of Scientists (1975), 116.
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The combination in time and space of all these thoughtful conceptions [of Nature] exhibits not only thought, it shows also premeditation, power, wisdom, greatness, prescience, omniscience, providence. In one word, all these facts in their natural connection proclaim aloud the One God, whom man may know, adore, and love; and Natural History must in good time become the analysis of the thoughts of the Creator of the Universe….
In Essay on Classification (1851), 205.
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The combination of some data and an aching desire for an answer does not ensure that a reasonable answer can be extracted from a given body of data.
In 'Sunset Salvo', The American Statistician (Feb 1986), 40, No. 1, 74-75.
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The combination of such characters, some, as the sacral ones, altogether peculiar among Reptiles, others borrowed, as it were, from groups now distinct from each other, and all manifested by creatures far surpassing in size the largest of existing reptiles, will, it is presumed, be deemed sufficient ground for establishing a distinct tribe or sub-order of Saurian Reptiles, for which I would propose the name of Dinosauria.
'Report on British Fossil Reptiles', Report of the Eleventh Meeting of the British Association for the Advancement of Science (1842), 103.
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The discovery of an interaction among the four hemes made it obvious that they must be touching, but in science what is obvious is not necessarily true. When the structure of hemoglobin was finally solved, the hemes were found to lie in isolated pockets on the surface of the subunits. Without contact between them how could one of them sense whether the others had combined with oxygen? And how could as heterogeneous a collection of chemical agents as protons, chloride ions, carbon dioxide, and diphosphoglycerate influence the oxygen equilibrium curve in a similar way? It did not seem plausible that any of them could bind directly to the hemes or that all of them could bind at any other common site, although there again it turned out we were wrong. To add to the mystery, none of these agents affected the oxygen equilibrium of myoglobin or of isolated subunits of hemoglobin. We now know that all the cooperative effects disappear if the hemoglobin molecule is merely split in half, but this vital clue was missed. Like Agatha Christie, Nature kept it to the last to make the story more exciting. There are two ways out of an impasse in science: to experiment or to think. By temperament, perhaps, I experimented, whereas Jacques Monod thought.
From essay 'The Second Secret of Life', collected in I Wish I'd Made You Angry Earlier (1998), 263-5.
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The elements of the living body have the chemical peculiarity of forming with each other most numerous combinations and very large molecules, consisting of five, six or even seven different elements.
In discourse (10 Dec 1893) to General Meeting, Nassau Association for Natural Science, Wiesbaden, Germany. Printed in 'The Distribution of the Organic Elements', The Chemical News and Journal of Industrial Science (1895), 71, No. 1832, 19.
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The hypotheses which we accept ought to explain phenomena which we have observed. But they ought to do more than this; our hypotheses ought to foretell phenomena which have not yet been observed; ... because if the rule prevails, it includes all cases; and will determine them all, if we can only calculate its real consequences. Hence it will predict the results of new combinations, as well as explain the appearances which have occurred in old ones. And that it does this with certainty and correctness, is one mode in which the hypothesis is to be verified as right and useful.
Philosophy of the Inductive Sciences (1847), Vol. 2, 62-63.
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The origin of an adaptive structure and the purposes it comes to fulfill are only chance combinations. Purposefulness is a very human conception for usefulness. It is usefulness looked at backwards. Hard as it is to imagine, inconceivably hard it may appear to many, that there is no direct relation between the origin of useful variations and the ends they come to serve, yet the modern zoologist takes his stand as a man of science on this ground. He may admit in secret to his father confessor, the metaphysician, that his poor intellect staggers under such a supposition, but he bravely carries forward his work of investigation along the only lines that he has found fruitful.
'For Darwin', The Popular Science Monthly (1909), 74, 380.
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The theory is confirmed that pea hybrids form egg and pollen cells, which, in their constitution, represent in equal numbers all constant forms which result for the combination of the characters united in fertilization.
As collected in Forest Ray Moulton (ed.), The Autobiography of Science (1945), 586.
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The work of the inventor consists of conceptualizing, combining, and ordering what is possible according to the laws of nature. This inner working out which precedes the external has a twofold characteristic: the participation of the subconscious in the inventing subject; and that encounter with an external power which demands and obtains complete subjugation, so that the way to the solution is experienced as the fitting of one's own imagination to this power.
Philosophie der Technik (1927). 'Technology in Its Proper Sphere' translated by William Carroll. In Carl Mitcham (ed.) and Robert Mackey (ed.), Philosophy and Technology: Readings in the Philosophical Problems of Technology, (1972), Vol. 14, 321. In David Lovekin, Technique, Discourse, and Consciousness (1991), 73.
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There is synthesis when, in combining therein judgments that are made known to us from simpler relations, one deduces judgments from them relative to more complicated relations.
There is analysis when from a complicated truth one deduces more simple truths.
In James R. Hofmann, André-Marie Ampčre (1996), 158. Cites Académie des Sciences Ampčre Archives, lecture notes, box 261.
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There is inherent in nature a hidden harmony that reflects itself in our minds under the image of simple mathematical laws. That then is the reason why events in nature are predictable by a combination of observation and mathematical analysis. Again and again in the history of physics this conviction, or should I say this dream, of harmony in nature has found fulfillments beyond our expectations.
…...
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We may lay it down as an incontestible axiom, that, in all the operations of art and nature, nothing is created; an equal quantity of matter exists both before and after the experiment; the quality and quantity of the elements remain precisely the same; and nothing takes place beyond changes and modifications in the combination of these elements. Upon this principle the whole art of performing chemical experiments depends: We must always suppose an exact equality between the elements of the body examined and those of the products of its analysis.
Elements of Chemistry trans. Robert. Kerr, (1790, 5th Ed. 1802), Vol. 1, 226.
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We must ascribe to all cells an independent vitality; that is, such combinations of molecules as occur in any single cell are capable of setting free the power by which it is enabled to take up fresh molecules.
In Theodor Schwann and Henry Smith (trans.), 'Theory of the Cells', Microscopical Researches Into the Accordance in the Structure and Growth of Animals and Plants (1839, 1847), 192.
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We set out, therefore, with the supposition that an organised body is not produced by a fundamental power which is guided in its operation by a definite idea, but is developed, according to blind laws of necessity, by powers which, like those of inorganic nature, are established by the very existence of matter. As the elementary materials of organic nature are not different from those of the inorganic kingdom, the source of the organic phenomena can only reside in another combination of these materials, whether it be in a peculiar mode of union of the elementary atoms to form atoms of the second order, or in the arrangement of these conglomerate molecules when forming either the separate morphological elementary parts of organisms, or an entire organism.
Mikroskopische Untersuchungen über die Uebereinstimmung in der Struktur und dem Wachsthum der Thiere und Pflanzen (1839). Microscopic Researches into the Accordance in the Structure and Growth of Animals and Plants, trans. Henry Smith (1847), 190-1.
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What quality is shared by all objects that provoke our aesthetic emotions? Only one answer seems possible—significant form. In each, lines and colors combined in a particular way; certain forms and relations of forms, stir our aesthetic emotions. These relations and combinations of lines and colours, these æsthetically moving forms, I call “Significant Form”; and “Significant Form” is the one quality common to all works of visual art.
In Art (1913), 8.
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What remains to be learned may indeed dwarf imagination. Nevertheless, the universe itself is closed and finite. … The uniformity of nature and the general applicability of natural laws set limits to knowledge. If there are just 100, or 105, or 110 ways in which atoms may form, then when one has identified the full range of properties of these, singly and in combination, chemical knowledge will be complete.
Presidential Address (28 Dec 1970) to the American Association for the Advancement of Science. 'Science: Endless Horizons or Golden Age?', Science (8 Jan 1971), 171, No. 3866, 24.
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What, in fact, is mathematical discovery? It does not consist in making new combinations with mathematical entities that are already known. That can be done by anyone, and the combinations that could be so formed would be infinite in number, and the greater part of them would be absolutely devoid of interest. Discovery consists precisely in not constructing useless combinations, but in constructing those that are useful, which are an infinitely small minority. Discovery is discernment, selection.
In Science et Méthode (1920), 48, as translated by Francis Maitland, in Science and Method (1908, 1952), 50-51.
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[Defining Life] The definite combination of heterogeneous changes, both simultaneous and successive, in correspondence with external co-existences and sequences.
Herbert Spencer, "Principles of Psychology" 1835, p. 354. Compare "Physiology of Common Life" 1860, ii., 426. In The British Controversialist and Literary Magazine (1865), 234.
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[Mitscherlich Law of Isomerism] An equal number of atoms, combined in the same way produce the same crystal forms, and the same crystal form does not depend on the nature of the atoms, but only on their number and mode of combination.
Originally published in 'Om Förhĺllandet emellan chemiska sammansättningen och krystallformen hos Arseniksyrade och Phosphorsyrade Salter', (On the Relation between the Chemical Composition and Crystal Form of Salts of Arsenic and Phosphoric Acids), Kungliga Svenska vetenskapsakademiens handlingar (1821), 4. This alternate translation of the law appears is given by F. Szabadváry article on 'Eilhard Mitscherlich' in Charles Coulston Gillispie (ed.), Dictionary of Scientific Biography (1974), Vol. 9, 424; perhaps from J.R. Partington, A History of Chemistry, Vol. 4 (1964), 210.
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[My] numberless observations... made on the Strata... [have] made me confident of their uniformity throughout this Country & [have] led me to conclude that the same regularity... will be found to extend to every part of the Globe for Nature has done nothing by piecemeal. [T]here is no inconsistency in her productions. [T]he Horse never becomes an Ass nor the Crab an Apple by any intermixture or artificial combination whatever[. N]or will the Oak ever degenerate into an Ash or an Ash into an Elm. [H]owever varied by Soil or Climate the species will still be distinct on this ground. [T]hen I argue that what is found here may be found elsewhere[.] When proper allowances are made for such irregularities as often occur and the proper situation and natural agreement is well understood I am satisfied there will be no more difficulty in ascertaining the true quality of the Strata and the place of its possition [sic] than there is now in finding the true Class and Character of Plants by the Linean [sic] System.
Natural Order of the Strata in England and Wales Accurately Delineated and Described, unpublished manuscript, Department of Geology, University of Oxford, 1801, f. 7v.
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[On gold, silver, mercury, platinum, palladium, rhodium, iridium, osmium:] As in their physical properties so in their chemical properties. Their affinities being weaker, (the noble metals) do not present that variety of combinations, belonging to the more common metals, which renders them so extensively useful in the arts; nor are they, in consequence, so necessary and important in the operations of nature. They do not assist in her hands in breaking down rocks and strata into soil, nor do they help man to make that soil productive or to collect for him its products.
From 13th Lecture in 1818, in Bence Jones, The Life and Letters of Faraday (1870), Vol. 1, 254.
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…comparing the capacity of computers to the capacity of the human brain, I’ve often wondered, where does our success come from? The answer is synthesis, the ability to combine creativity and calculation, art and science, into whole that is much greater than the sum of its parts.
In How Life Imitates Chess: Making the Right Moves, from the Board to the Boardroom (2007), 4.
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Carl Sagan Thumbnail In science it often happens that scientists say, 'You know that's a really good argument; my position is mistaken,' and then they would actually change their minds and you never hear that old view from them again. They really do it. It doesn't happen as often as it should, because scientists are human and change is sometimes painful. But it happens every day. I cannot recall the last time something like that happened in politics or religion. (1987) -- Carl Sagan
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