1839—The fermentation satire
THE MYSTERY OF ALCOHOLIC FERMENTATION RESOLVED
(Preliminary Report by Letter) Schwindler
I am about to develop a new theory of wine fermentation … Depending on the weight, these seeds carry fermentation to completion somewhat less than as in the beginning, which is understandable … I shall develop a new theory of wine fermentation [showing] what simple means Nature employs in creating the most amazing phenomena. I owe it to the use of an excellent microscope designed by Pistorius.
When brewer’s yeast is mixed with water the microscope reveals that the yeast dissolves into endless small balls, which are scarcely 1/800th of a line in diameter … If these small balls are placed in sugar water, it can be seen that they consist of the eggs of animals. As they expand, they burst, and from them develop small creatures that multiply with unbelievable rapidity in a most unheard of way. The form of these animals differs from all of the 600 types described up until now. They possess the shape of a Beinsdorff still (without the cooling apparatus). The head of the tube is a sort of proboscis, the inside of which is filled with fine bristles 1/2000th of a line long. Teeth and eyes are not discernible; however, a stomach, intestinal canal, anus (a rose red dot), and organs for secretion of urine are plainly discernible. From the moment they are released from the egg one can see these animals swallow the sugar from the solution and pass it to the stomach. It is digested immediately, a process recognized easily by the resultant evacuation of excrements. In a word, these infusors eat sugar, evacuate ethyl alcohol from the intestinal canal, and carbon dioxide from the urinary organs. The bladder, in the filled state, has the form of a champagne bottle; when empty, it is a small button … As soon as the animals find no more sugar present, they eat each other up, which occurs through a peculiar manipulation; everything is digested down to the eggs which pass unchanged through the intestinal canal. Finally, one again fermentable yeast, namely the seed of the animals, which remain over.

A man in twenty-four hours converts as much as seven ounces of carbon into carbonic acid; a milch cow will convert seventy ounces, and a horse seventy-nine ounces, solely by the act of respiration. That is, the horse in twenty-four hours burns seventy-nine ounces of charcoal, or carbon, in his organs of respiration to supply his natural warmth in that time ..., not in a free state, but in a state of combination.

But nothing of a nature foreign to the duties of my profession [clergyman] engaged my attention while I was at Leeds so much as the, prosecution of my experiments relating to electricity, and especially the doctrine of air. The last I was led into a consequence of inhabiting a house adjoining to a public brewery, where first amused myself with making experiments on fixed air [carbon dioxide] which found ready made in the process of fermentation. When I removed from that house, I was under the necessity making the fixed air for myself; and one experiment leading to another, as I have distinctly and faithfully noted in my various publications on the subject, I by degrees contrived a convenient apparatus for the purpose, but of the cheapest kind. When I began these experiments I knew very little of chemistry, and had in a manner no idea on the subject before I attended a course of chymical lectures delivered in the Academy at Warrington by Dr. Turner of Liverpool. But I have often thought that upon the whole, this circumstance was no disadvantage to me; as in this situation I was led to devise an apparatus and processes of my own, adapted to my peculiar views. Whereas, if I had been previously accustomed to the usual chemical processes, I should not have so easily thought of any other; and without new modes of operation I should hardly have discovered anything materially new.

By blending water and minerals from below with sunlight and CO₂ from above, green plants link the earth to the sky. We tend to believe that plants grow out of the soil, but in fact most of their substance comes from the air. The bulk of the cellulose and the other organic compounds produced through photosynthesis consists of heavy carbon and oxygen atoms, which plants take directly from the air in the form of CO₂. Thus the weight of a wooden log comes almost entirely from the air. When we burn a log in a fireplace, oxygen and carbon combine once more into CO₂, and in the light and heat of the fire we recover part of the solar energy that went into making the wood.

For the same energy output as from coal or oil, methane combustion releases only half as much carbon dioxide. This implies that powering a nation entirely by gas reduces emissions of carbon dioxide by half. … The problem with [production leaks and other escapes of] … methane is that this substance is twenty-four times more potent a greenhouse gas than carbon dioxide.

I find it sad, but all too human, that there are vast bureaucracies concerned about nuclear waste, huge organizations devoted to decommissioning nuclear power stations, but nothing comparable to deal with that truly malign waste, carbon dioxide.

In fact, the thickness of the Earth's atmosphere, compared with the size of the Earth, is in about the same ratio as the thickness of a coat of shellac on a schoolroom globe is to the diameter of the globe. That's the air that nurtures us and almost all other life on Earth, that protects us from deadly ultraviolet light from the sun, that through the greenhouse effect brings the surface temperature above the freezing point. (Without the greenhouse effect, the entire Earth would plunge below the freezing point of water and we'd all be dead.) Now that atmosphere, so thin and fragile, is under assault by our technology. We are pumping all kinds of stuff into it. You know about the concern that chlorofluorocarbons are depleting the ozone layer; and that carbon dioxide and methane and other greenhouse gases are producing global warming, a steady trend amidst fluctuations produced by volcanic eruptions and other sources. Who knows what other challenges we are posing to this vulnerable layer of air that we haven't been wise enough to foresee?

In my position you can’t go out and just say, “I think,” because it’s a very serious thing. So if you get up and say climate is changing because of CO2 emissions, you better bloody well be right.

Incandescent carbon particles, by the tens of millions, leap free of the log and wave like banners, as flame. Several hundred significantly different chemical reactions are now going on. For example, a carbon atom and four hydrogen atoms, coming out of the breaking cellulose, may lock together and form methane, natural gas. The methane, burning (combining with oxygen), turns into carbon dioxide and water, which also go up the flue. If two carbon atoms happen to come out of the wood with six hydrogen atoms, they are, agglomerately, ethane, which bums to become, also, carbon dioxide and water. Three carbons and eight hydrogens form propane, and propane is there, too, in the fire. Four carbons and ten hydrogens—butane. Five carbons … pentane. Six … hexane. Seven … heptane. Eight carbons and eighteen hydrogens—octane. All these compounds come away in the breaking of the cellulose molecule, and burn, and go up the chimney as carbon dioxide and water. Pentane, hexane, heptane, and octane have a collective name. Logs burning in a fireplace are making and burning gasoline.

It is the destiny of wine to be drunk, and it is the destiny of glucose to be oxidized. But it was not oxidized immediately: its drinker kept it in his liver for more than a week, well curled up and tranquil, as a reserve aliment for a sudden effort; an effort that he was forced to make the following Sunday, pursuing a bolting horse. Farewell to the hexagonal structure: in the space of a few instants the skein was unwound and became glucose again, and this was dragged by the bloodstream all the way to a minute muscle fiber in the thigh, and here brutally split into two molecules of lactic acid, the grim harbinger of fatigue: only later, some minutes after, the panting of the lungs was able to supply the oxygen necessary to quietly oxidize the latter. So a new molecule of carbon dioxide returned to the atmosphere, and a parcel of the energy that the sun had handed to the vine-shoot passed from the state of chemical energy to that of mechanical energy, and thereafter settled down in the slothful condition of heat, warming up imperceptibly the air moved by the running and the blood of the runner. 'Such is life,' although rarely is it described in this manner: an inserting itself, a drawing off to its advantage, a parasitizing of the downward course of energy, from its noble solar form to the degraded one of low-temperature heat. In this downward course, which leads to equilibrium and thus death, life draws a bend and nests in it.

Man has generally been preoccupied with obtaining as much “production” from the landscape as possible, by developing and maintaining early successional types of ecosystems, usually monocultures. But, of course, man does not live by food and fiber alone; he also needs a balanced CO2-O2 atmosphere, the climactic buffer provided by oceans and masses of vegetation, and clean (that is, unproductive) water for cultural and industrial uses. Many essential life-cycle resources, not to mention recreational and esthetic needs, are best provided man by the less 'productive' landscapes. In other words, the landscape is not just a supply depot but is also the oikos—the home—in which we must live.

Many people believe the whole catastrophe is the oil we spill, but that gets diluted and eventually disarmed over time. In fact, the oil we don't spill, the oil we collect, refine and use, produces CO2 and other gases that don't get diluted.

Once the forest has been removed and the swamp starts being drained, that organic matter begins to oxidise and give off continuing emissions. It’s sort of like the goose that keeps on giving.

The absorption of oxygen and the elimination of carbon dioxide in the lungs take place by diffusion alone. There is no trustworthy evidence of any regulation of this process on the part of the organism.

The carbon output that melts the ice in the Arctic also causes ocean acidification, which results from the ocean absorbing excess carbon dioxide from the atmosphere (the same carbon dioxide that is the primary cause of global warming, hence the nickname “the other carbon problem”).

The discovery of an interaction among the four hemes made it obvious that they must be touching, but in science what is obvious is not necessarily true. When the structure of hemoglobin was finally solved, the hemes were found to lie in isolated pockets on the surface of the subunits. Without contact between them how could one of them sense whether the others had combined with oxygen? And how could as heterogeneous a collection of chemical agents as protons, chloride ions, carbon dioxide, and diphosphoglycerate influence the oxygen equilibrium curve in a similar way? It did not seem plausible that any of them could bind directly to the hemes or that all of them could bind at any other common site, although there again it turned out we were wrong. To add to the mystery, none of these agents affected the oxygen equilibrium of myoglobin or of isolated subunits of hemoglobin. We now know that all the cooperative effects disappear if the hemoglobin molecule is merely split in half, but this vital clue was missed. Like Agatha Christie, Nature kept it to the last to make the story more exciting. There are two ways out of an impasse in science: to experiment or to think. By temperament, perhaps, I experimented, whereas Jacques Monod thought.

The great rapidity with which we add carbon gases to the air is as damaging as is the quantity.

The wild gas, the fixed air is plainly broke loose: but we ought to suspend our judgments until the first effervescence is a little subsided, till the liquor is cleared, and until we see something deeper than the agitation of the troubled and frothy surface.
[About the “spirit of liberty;” alluding to Priestley’s Observations on Air]

Through the discovery of Buchner, Biology was relieved of another fragment of mysticism. The splitting up of sugar into CO₂ and alcohol is no more the effect of a 'vital principle' than the splitting up of cane sugar by invertase. The history of this problem is instructive, as it warns us against considering problems as beyond our reach because they have not yet found their solution.

To wage war with Marchand or anyone else again will benefit nobody and bring little profit to science. You consume yourself in this way, you ruin your liver and eventually your nerves with Morrison pills. Imagine the year 1900 when we have disintegrated into carbonic acid, ammonia and water and our bone substance is perhaps once more a constituent of the bones of the dog who defiles our graves. Who will then worry his head as to whether we have lived in peace or anger, who then will know about your scientific disputes and of your sacrifice of health and peace of mind for science? Nobody. But your good ideas and the discoveries you have made, cleansed of all that is extraneous to the subject, will still be known and appreciated for many years to come. But why am I trying to advise the lion to eat sugar.

We need to be realistic. There is very little we can do now to stop the ice from disappearing from the North Pole in the Summer. And we probably cannot prevent the melting of the permafrost and the resulting release of methane. In addition, I fear that we may be too late to help the oceans maintain their ability to absorb carbon dioxide. But there is something we can do—and it could make the whole difference and buy us time to develop the necessary low carbon economies. We can halt the destruction of the world’s rainforests—and even restore parts of them—in order to ensure that the forests do what they are so good at—in other words storing carbon naturally. This is a far easier, cheaper and quicker option than imagining we can rely on as yet unproven technology to capture carbon at a cost of some $50 per tonne or, for that matter, imagining we can achieve what is necessary through plantation timber.

When air has been freshly and strongly tainted with putrefaction, so as to smell through the water, sprigs of mint have presently died, upon being put into it, their leaves turning black; but if they do not die presently, they thrive in a most surprizing manner. In no other circumstances have I ever seen vegetation so vigorous as in this kind of air, which is immediately fatal to animal life. Though these plants have been crouded in jars filled with this air, every leaf has been full of life; fresh shoots have branched out in various , and have grown much faster than other similiar plants, growing in the same exposure in common air.
This observation led me to conclude that plants, instead of affecting the air in the same manner with animal respiration, reverse the effects of breathing, and tend to keep the atmosphere sweet and wholesome, when it is become noxious, in consequence on animals living and breathing, or dying and putrefying in it.
In order to ascertain this, I took a quantity of air, made thoroughly noxious, by mice breathing and dying in it, and divided it into two parts; one of which I put into a phial immersed in water; and to the other (which was contained in a glass jar, standing in water) I put a sprig of mint. This was about the beginning of August 1771, and after eight or nine days, I found that a mouse lived perfectly well in that part of the air, in which the sprig of mint had grown, but died the moment it was put into the other part of the same original quantity of air; and which I had kept in the very same exposure, but without any plant growing in it.

When ultra-violet light acts on a mixture of water, carbon dioxide, and ammonia, a vast variety of organic substances are made, including sugars and apparently some of the materials from which proteins are built up…. But before the origin of life they must have accumulated till the primitive oceans reached the consistency of hot dilute soup…. The first living or half-living things were probably large molecules synthesized under the influence of the sun’s radiation, and only capable of reproduction in the particularly favorable medium in which they originated….

You can’t see oxygen being generated by trees, carbon dioxide being taken up by trees, but we get that. We’re beginning to understand the importance of forests. But the ocean has its forests, too. They just happen to be very small. They’re very small in size but they’re very large in numbers.

You will be astonished when I tell you what this curious play of carbon amounts to. A candle will burn some four, five, six, or seven hours. What, then, must be the daily amount of carbon going up into the air in the way of carbonic acid! ... Then what becomes of it? Wonderful is it to find that the change produced by respiration ... is the very life and support of plants and vegetables that grow upon the surface of the earth.