[A woman waiting for him in the Kremlin asked Gobachev] “Was communism invented by a politician or a scientist?” [He replied] “Well, a politician.” She said, “That explains it. The scientist would have tried it on mice first.”

[Using mice as model systems for genetic engineering in biomedicine, instead of bacterial or yeast systems matters because] this transition will have as big an impact on the future of biology as the shift from printing presses to video technology has had on pop culture. A mouse-based world looks and feels different from one viewed through microorganisms.

A fox looked at his shadow at sunrise and said, “I will have a camel for lunch today.” And all morning he went about looking for camels. But at noon he saw his shadow again - and he said, “A mouse will do.”

A moment’s consideration of this case shows what a really great advance in the theory and practise of breeding has been obtained through the discovery of Mendel’s law. What a puzzle this case would have presented to the biologist ten years ago! Agouti crossed with chocolate gives in the second filial generation (not in the first) four varieties, viz., agouti, chocolate, black and cinnamon. We could only have shaken our heads and looked wise (or skeptical).
Then we had no explanation to offer for such occurrences other than the “instability of color characters under domestication,” the “effects of inbreeding,” “maternal impressions.” Serious consideration would have been given to the proximity of cages containing both black and cinnamon-agouti mice.
Now we have a simple, rational explanation, which anyone can put to the test. We are able to predict the production of new varieties, and to produce them.
We must not, of course, in our exuberance, conclude that the powers of the hybridizer know no limits. The result under consideration consists, after all, only in the making of new combinations of unit characters, but it is much to know that these units exist and that all conceivable combinations of them are ordinarily capable of production. This valuable knowledge we owe to the discoverer and to the rediscoverers of Mendel’s law.

A mouse can fall down a mine shaft a third of a mile deep without injury. A rat falling the same distance would break his bones; a man would simply splash ... Elephants have their legs thickened to an extent that seems disproportionate to us, but this is necessary if their unwieldly bulk is to be moved at all ... A 60-ft. man would weigh 1000 times as much as a normal man, but his thigh bone would have its area increased by only 100 times ... Consequently such an unfortunate monster would break his legs the moment he tried to move.
Expressing, in picturesque terms, the strength of an organism relative to its bulk.

American scientific companies are cross-breeding humans and animals and coming up with mice with fully functioning human brains.

Cat-Ideas and Mouse-Ideas. We can never get rid of mouse-ideas completely, they keep turning up again and again, and nibble, nibble—no matter how often we drive them off. The best way to keep them down is to have a few good strong cat-ideas which will embrace them and ensure their not reappearing till they do so in another shape.

Every complete set of chromosomes contains the full code; so there are, as a rule, two copies of the latter in the fertilized egg cell, which forms the earliest stage of the future individual. In calling the structure of the chromosome fibres a code-script we mean that the all-penetrating mind, once conceived by Laplace, to which every causal connection lay immediately open, could tell from their structure whether the egg would develop, under suitable conditions, into a black cock or into a speckled hen, into a fly or a maize plant, a rhododendron, a beetle, a mouse or a woman. To which we may add, that the appearances of the egg cells are very often remarkably similar; and even when they are not, as in the case of the comparatively gigantic eggs of birds and reptiles, the difference is not so much in the relevant structures as in the nutritive material which in these cases is added for obvious reasons.
But the term code-script is, of course, too narrow. The chromosome structures are at the same time instrumental in bringing about the development they foreshadow. They are law-code and executive power?or, to use another simile, they are architect's plan and builder’s craft-in one.

Gravity, a mere nuisance to Christian, was a terror to Pope, Pagan, and Despair. You can drop a mouse down a thousand-yard mine shaft; and, on arriving at the bottom, it gets a slight shock and walks away, provided that the ground is fairly soft. A rat is killed, a man is broken, a horse splashes.

I am not a scientist.

I can conceive few human states more enviable than that of the man to whom, panting in the foul laboratory, or watching for his life under the tropic forest, Isis shall for a moment lift her sacred veil, and show him, once and for ever, the thing he dreamed not of; some law, or even mere hint of a law, explaining one fact; but explaining with it a thousand more, connecting them all with each other and with the mighty whole, till order and meaning shoots through some old Chaos of scattered observations.

I have procured some of the mice mentioned in my former letters, a young one and a female with young, both of which I have preserved in brandy. From the colour, shape, size, and manner of nesting, I make no doubt but that the species is nondescript [not known to science]. They are much smaller and more slender than the mus domesticus medius of Ray; and have more of the squirrel or dormouse colour ... They never enter into houses; are carried into ricks and barns with the sheaves; abound in harvest, and build their nests amidst the straws of the corn above the ground, and sometimes in thistles.
[Part of his observations on the harvest mouse, which he was the first to describe as a new species.]

I sometimes see a bird’s nest in a thorn or other bush half full of acorns and hazel-nut shells, where evidently some mouse or squirrel has left them.

If a man write a better book, preach a better sermon, or make a better mouse-trap than his neighbour, tho' he build his house in the woods, the world will make a beaten path to his door.

If we assume that there is only one enzyme present to act as an oxidizing agent, we must assume for it as many different degrees of activity as are required to explain the occurrence of the various colors known to mendelize (three in mice, yellow, brown, and black). If we assume that a different enzyme or group of enzymes is responsible for the production of each pigment we must suppose that in mice at least three such enzymes or groups of enzymes exist. To determine which of these conditions occurs in mice is not a problem for the biologist, but for the chemist. The biologist must confine his attention to determining the number of distinct agencies at work in pigment formation irrespective of their chemical nature. These agencies, because of their physiological behavior, the biologist chooses to call 'factors,' and attempts to learn what he can about their functions in the evolution of color varieties.

If you can modify a cell, it’s only a short step to modifying a mouse, and if you can modify a mouse, it’s only a step to modifying a higher animal, even man.
Reported in 1981, expressing concern for the future of gene-splicing.

In 1906 I indulged my temper by hurling invectives at Neo-Darwinians in the following terms. “I really do not wish to be abusive [to Neo-Darwinians]; but when I think of these poor little dullards, with their precarious hold of just that corner of evolution that a blackbeetle can understand—with their retinue of twopenny-halfpenny Torquemadas wallowing in the infamies of the vivisector’s laboratory, and solemnly offering us as epoch-making discoveries their demonstrations that dogs get weaker and die if you give them no food; that intense pain makes mice sweat; and that if you cut off a dog’s leg the three-legged dog will have a four-legged puppy, I ask myself what spell has fallen on intelligent and humane men that they allow themselves to be imposed on by this rabble of dolts, blackguards, imposters, quacks, liars, and, worst of all, credulous conscientious fools.”

In a purely technical sense, each species of higher organism—beetle, moss, and so forth, is richer in information than a Caravaggio painting, Mozart symphony, or any other great work of art. Consider the typical case of the house mouse, Mus musculus. Each of its cells contains four strings of DNA, each of which comprises about a billion nucleotide pairs organized into a hundred thousand structural nucleotide pairs, organized into a hundred thousand structural genes. … The full information therein, if translated into ordinary-sized printed letters, would just about fill all 15 editions of the Encyclopaedia Britannica published since 1768.

Life is hard for insects. And don’t think mice are having any fun either.

MOUSE, n. An animal which strews its path with fainting women.

The feeling of it to my lungs was not sensibly different from that of common air; but I fancied that my breast felt peculiarly light and easy for some time afterwards. Who can tell but that, in time, this pure air may become a fashionable article in luxury. Hitherto only two mice and myself have had the privilege of breathing it.

The fertilized ovum of a mouse and a whale look much alike, but differences quickly show up in the course of their development. If we could study their molecules with the naked eyes, we would see the differences from the start.

The fertilized ovum of a mouse and a whale look much alike, but differences quickly show up in the course of their development. If we could study their molecules with the naked eyes, we would see the differences from the start.

The foundations of population genetics were laid chiefly by mathematical deduction from basic premises contained in the works of Mendel and Morgan and their followers. Haldane, Wright, and Fisher are the pioneers of population genetics whose main research equipment was paper and ink rather than microscopes, experimental fields, Drosophila bottles, or mouse cages. Theirs is theoretical biology at its best, and it has provided a guiding light for rigorous quantitative experimentation and observation.

The goal of science is to build better mousetraps. The goal of nature is to build better mice.

The line separating investment and speculation, which is never bright and clear, becomes blurred still further when most market participants have recently enjoyed triumphs. Nothing sedates rationality like large doses of effortless money. After a heady experience of that kind, normally sensible people drift into behavior akin to that of Cinderella at the ball. They know that overstaying the festivities—that is, continuing to speculate in companies that have gigantic valuations relative to the cash they are likely to generate in the future—will eventually bring on pumpkins and mice. But they nevertheless hate to miss a single minute of what is one helluva party. Therefore, the giddy participants all plan to leave just seconds before midnight. There’s a problem, though: They are dancing in a room in which the clocks have no hands.

The number of humble-bees in any district depends in a great degree on the number of field-mice, which destroy their combs and nests; and Mr. H. Newman, who has long attended to the habits of humble-bees, ... says “Near villages and small towns I have found the nests of humble-bees more numerous than elsewhere, which I attribute to the number of cats that destroy the mice.” Hence it is quite credible that the presence of a feline animal in large numbers in a district might determine, through the intervention first of mice and then of bees, the frequency of certain flowers in that district!

The rat, the mouse, the fox, the rabbit, watch the roots; the lion, the tiger, the horse, the elephant the fruits.

Through the naturalist’s eyes, a sparrow can be as interesting as a bird of paradise, the behaviour of a mouse as interesting as that of a tiger, and a humble lizard as fascinating as a crocodile. … Our planet is beautifully intricate, brimming over with enigmas to be solved and riddles to be unravelled.

We do 'custom-tailor' mice. We view them as the canvas upon which we do these genetic transplantations.

What is this frog and mouse battle among the mathematicians?

When air has been freshly and strongly tainted with putrefaction, so as to smell through the water, sprigs of mint have presently died, upon being put into it, their leaves turning black; but if they do not die presently, they thrive in a most surprizing manner. In no other circumstances have I ever seen vegetation so vigorous as in this kind of air, which is immediately fatal to animal life. Though these plants have been crouded in jars filled with this air, every leaf has been full of life; fresh shoots have branched out in various , and have grown much faster than other similiar plants, growing in the same exposure in common air.
This observation led me to conclude that plants, instead of affecting the air in the same manner with animal respiration, reverse the effects of breathing, and tend to keep the atmosphere sweet and wholesome, when it is become noxious, in consequence on animals living and breathing, or dying and putrefying in it.
In order to ascertain this, I took a quantity of air, made thoroughly noxious, by mice breathing and dying in it, and divided it into two parts; one of which I put into a phial immersed in water; and to the other (which was contained in a glass jar, standing in water) I put a sprig of mint. This was about the beginning of August 1771, and after eight or nine days, I found that a mouse lived perfectly well in that part of the air, in which the sprig of mint had grown, but died the moment it was put into the other part of the same original quantity of air; and which I had kept in the very same exposure, but without any plant growing in it.

You are literally filled with the fruit of your own devices, with rats and mice and such small deer, paramecia, and entomostraceæ, and kicking things with horrid names, which you see in microscopes at the Polytechnic, and rush home and call for brandy—without the water—stone, and gravel, and dyspepsia, and fragments of your own muscular tissue tinged with your own bile.