[O]ur long-term security is threatened by a problem at least as dangerous as chemical, nuclear or biological weapons, or indeed international terrorism: human-induced climate change. … The impacts of global warming are such that I have no hesitation in describing it as a “weapon of mass destruction.” Like terrorism, this weapon knows no boundaries. It can strike anywhere, in any form…

[The biggest myth in business is that] bigger is better. A business should be judged not by its size but its impact.

[To the cultures of Asia and the continent of Africa] it is the Western impact which has stirred up the winds of change and set the processes of modernization in motion. Education brought not only the idea of equality but also another belief which we used to take for granted in the West—the idea of progress, the idea that science and technology can be used to better human conditions. In ancient society, men tended to believe themselves fortunate if tomorrow was not worse than today and anyway, there was little they could do about it.

[Using mice as model systems for genetic engineering in biomedicine, instead of bacterial or yeast systems matters because] this transition will have as big an impact on the future of biology as the shift from printing presses to video technology has had on pop culture. A mouse-based world looks and feels different from one viewed through microorganisms.

[About reading Rachel Carson's Silent Spring, age 14, in the back seat of his parents' sedan. I almost threw up. I got physically ill when I learned that ospreys and peregrine falcons weren't raising chicks because of what people were spraying on bugs at their farms and lawns. This was the first time I learned that humans could impact the environment with chemicals. [That a corporation would create a product that didn't operate as advertised] was shocking in a way we weren't inured to.

Among the current discussions, the impact of new and sophisticated methods in the study of the past occupies an important place. The new 'scientific' or 'cliometric' history—born of the marriage contracted between historical problems and advanced statistical analysis, with economic theory as bridesmaid and the computer as best man—has made tremendous advances in the last generation.

Any child born into the hugely consumptionist way of life so common in the industrial world will have an impact that is, on average, many times more destructive than that of a child born in the developing world.

As scientific men we have all, no doubt, felt that our fellow men have become more and more satisfying as fish have taken up their work which has been put often to base uses, which must lead to disaster. But what sin is to the moralist and crime to the jurist so to the scientific man is ignorance. On our plane, knowledge and ignorance are the immemorial adversaries. Scientific men can hardly escape the charge of ignorance with regard to the precise effect of the impact of modern science upon the mode of living of the people and upon their civilisation. For them, such a charge is worse than that of crime.

AZT stood up and said, 'Stop your pessimism. Stop your sense of futility. Go back to the lab. Go back to development. Go back to clinical trials. Things will work.'
[On the impact of AZT emerging as the long-sought first significant AIDS drug.]

Civilization is in no immediate danger of running out of energy or even just out of oil. But we are running out of environment—that is, out of the capacity of the environment to absorb energy's impacts without risk of intolerable disruption—and our heavy dependence on oil in particular entails not only environmental but also economic and political liabilities.

Climate change threatens every corner of our country, every sector of our economy and the health and future of every child. We are already seeing its impacts and we know the poorest and most vulnerable people in the United States and around the world will suffer most of all.

Conservation is getting nowhere because it is incompatible with our Abrahamic concept of land. We abuse land because we regard it as a commodity belonging to us. When we see land as a community to which we belong, we may begin to use it with love and respect. There is no other way for land to survive the impact of mechanized man, nor for us to reap from it the esthetic harvest it is capable, under science, of contributing to culture.

During my span of life science has become a matter of public concern and the l'art pour l'art standpoint of my youth is now obsolete. Science has become an integral and most important part of our civilization, and scientific work means contributing to its development. Science in our technical age has social, economic, and political functions, and however remote one's own work is from technical application it is a link in the chain of actions and decisions which determine the fate of the human race. I realized this aspect of science in its full impact only after Hiroshima.

Five centuries ago the printing press sparked a radical reshaping of the nature of education. By bringing a master’s words to those who could not hear a master’s voice, the technology of printing dissolved the notion that education must be reserved for those with the means to hire personal tutors. Today we are approaching a new technological revolution, one whose impact on education may be as far-reaching as that of the printing press: the emergence of powerful computers that are sufficiently inexpensive to be used by students for learning, play and exploration. It is our hope that these powerful but simple tools for creating and exploring richly interactive environments will dissolve the barriers to the production of knowledge as the printing press dissolved the barriers to its transmission.

Global nuclear war could have a major impact on climate—manifested by significant surface darkening over many weeks, subfreezing land temperatures persisting for up to several months, large perturbations in global circulation patterns, and dramatic changes in local weather and precipitation rates—a harsh “nuclear winter” in any season. [Co-author with Carl Sagan]

However, the small probability of a similar encounter [of the earth with a comet], can become very great in adding up over a huge sequence of centuries. It is easy to picture to oneself the effects of this impact upon the Earth. The axis and the motion of rotation changed; the seas abandoning their old position to throw themselves toward the new equator; a large part of men and animals drowned in this universal deluge, or destroyed by the violent tremor imparted to the terrestrial globe.

Human societies increased the abundance and distribution of useful species. This can also be used to preserve the forest, I think. We can use this as an opportunity to reduce the impacts of deforestation. Now we have huge plantations of soybeans that are destroying the Amazon—while in the forest we have lots of plants that can be used while maintaining the forest as it is.

I have no doubt that many small strikes of a hammer will finally have as much effect as one very heavy blow: I say as much in quantity, although they may be different in mode, but in my opinion, everything happens in nature in a mathematical way, and there is no quantity that is not divisible into an infinity of parts; and Force, Movement, Impact etc. are types of quantities.

I have satisfied myself that the [cosmic] rays are not generated by the formation of new matter in space, a process which would be like water running up a hill. Nor do they come to any appreciable amount from the stars. According to my investigations the sun emits a radiation of such penetrative power that it is virtually impossible to absorb it in lead or other substances. ... This ray, which I call the primary solar ray, gives rise to a secondary radiation by impact against the cosmic dust scattered through space. It is the secondary radiation which now is commonly called the cosmic ray, and comes, of course, equally from all directions in space. [The article continues: The phenomena of radioactivity are not the result of forces within the radioactive substances but are caused by this ray emitted by the sun. If radium could be screened effectively against this ray it would cease to be radioactive, he said.]

I like the word “nanotechnology.” I like it because the prefix “nano” guarantees it will be fundamental science for decades; the “technology” says it is engineering, something you’re involved in not just because you’re interested in how nature works but because it will produce something that has a broad impact.

If Watson and I had not discovered the [DNA] structure, instead of being revealed with a flourish it would have trickled out and that its impact would have been far less. For this sort of reason Stent had argued that a scientific discovery is more akin to a work of art than is generally admitted. Style, he argues, is as important as content. I am not completely convinced by this argument, at least in this case.

It is my belief that the basic knowledge that we're providing to the world will have a profound impact on the human condition and the treatments for disease and our view of our place on the biological continuum.

Man must at all costs overcome the Earth’s gravity and have, in reserve, the space at least of the Solar System. All kinds of danger wait for him on the Earth… We are talking of disaster that can destroy the whole of mankind or a large part of it… For instance, a cloud of bolides [meteors] or a small planet a few dozen kilometers in diameter could fall on the Earth, with such an impact that the solid, liquid or gaseous blast produced by it could wipe off the face of the Earth all traces of man and his buildings. The rise of temperature accompanying it could alone scorch or kill all living beings… We are further compelled to take up the struggle against gravity, and for the utilization of celestial space and all its wealth, because of the overpopulation of our planet. Numerous other terrible dangers await mankind on the Earth, all of which suggest that man should look for a way into the Cosmos. We have said a great deal about the advantages of migration into space, but not all can be said or even imagined.

Mathematics is a structure providing observers with a framework upon which to base healthy, informed, and intelligent judgment. Data and information are slung about us from all directions, and we are to use them as a basis for informed decisions. … Ability to critically analyze an argument purported to be logical, free of the impact of the loaded meanings of the terms involved, is basic to an informed populace.

Mutations and chromosomal changes arise in every sufficiently studied organism with a certain finite frequency, and thus constantly and unremittingly supply the raw materials for evolution. But evolution involves something more than origin of mutations. Mutations and chromosomal changes are only the first stage, or level, of the evolutionary process, governed entirely by the laws of the physiology of individuals. Once produced, mutations are injected in the genetic composition of the population, where their further fate is determined by the dynamic regularities of the physiology of populations. A mutation may be lost or increased in frequency in generations immediately following its origin, and this (in the case of recessive mutations) without regard to the beneficial or deleterious effects of the mutation. The influences of selection, migration, and geographical isolation then mold the genetic structure of populations into new shapes, in conformity with the secular environment and the ecology, especially the breeding habits, of the species. This is the second level of the evolutionary process, on which the impact of the environment produces historical changes in the living population.

My crystal ball or intuition tells me that in the '80s the impact of RIA [radioimmunoassay] on the study of infectious diseases may prove as revolutionary as its impact on endocrinology in the 60s.

My sense is that the most under-appreciated–and perhaps most under-researched–linkages between forests and food security are the roles that forest-based ecosystem services play in underpinning sustainable agricultural production. Forests regulate hydrological services including the quantity, quality, and timing of water available for irrigation. Forest-based bats and bees pollinate crops. Forests mitigate impacts of climate change and extreme weather events at the landscape scale.

Plants, generally speaking, meet the impact of the terrestrial environment head on, although of course they in turn modify the physical environment by adventitious group activity. The individual plant cannot select its habitat; its location is largely determined by the vagaries of the dispersal of seeds or spores and is thus profoundly affected by chance. Because of their mobility and their capacity for acceptance or rejection terrestrial animals, in contrast, can and do actively seek out and utilize the facets of the environment that allow their physiological capacities to function adequately. This means that an animal by its behavior can fit the environment to its physiology by selecting situations in which its physiological capacities can cope with physical conditions. If one accepts this idea, it follows that there is no such thing as The Environment, for there exist as many different terrestrial environments as there are species of animals.

Producing food for 6.2 billion people, adding a population of 80 million more a year, is not simple. We better develop an ever improved science and technology, including the new biotechnology, to produce the food that’s needed for the world today. In response to the fraction of the world population that could be fed if current farmland was convered to organic-only crops: “We are 6.6 billion people now. We can only feed 4 billion. I don’t see 2 billion volunteers to disappear.” In response to extreme critics: “These are utopian people that live on Cloud 9 and come into the third world and cause all kinds of confusion and negative impacts on the developing countries.”

Success is being able to make an impact in what matters most to you.

Testing the impact of public health interventions in response to the null hypothesis may help reduce avoidable hubris in expectations of benefits.

The full impact of the Lobatchewskian method of challenging axioms has probably yet to be felt. It is no exaggeration to call Lobatchewsky the Copernicus of Geometry,* for geometry is only a part of the vaster domain which he renovated; it might even be just to designate him as a Copernicus of all thought.

The hybridoma technology was a by-product of basic research. Its success in practical applications is to a large extent the result of unexpected and unpredictable properties of the method. It thus represents another clear-cut example of the enormous practical impact of an investment in research which might not have been considered commercially worthwhile, or of immediate medical relevance. It resulted from esoteric speculations, for curiosity’s sake, only motivated by a desire to understand nature.

The impact of an army, like the total mechanical coefficients, is equal to the mass multiplied by the velocity.

The more innocuous the name of a weapon, the more hideous its impact. (Some of the most horrific weapons of the Vietnam era were named “Bambi”, “Infant”, “Daisycutter”, “Grasshopper”, and “Agent Orange.” Nor is the trend new: from the past we have “Mustard Gas”, “Angel Chasers” (two cannonballs linked with a chain for added destruction) and “The Peacemaker” to name but a few.)

The world won’t come to an end, but the incidence of disasters will have a very big impact, and in ways we can't predict. … Rises in seas levels will displace millions of people. It’s estimated there will be 150 million refugees by 2050, homeless as a result of global warming. It’s how we deal with these problems that is as much the challenge as tackling the causes of global warming.

Very old and wide-spread is the opinion that forests have an important impact on rainfall. ... If forests enhance the amount and frequency of precipitation simply by being there, deforestation as part of agricultural expansion everywhere, must necessarily result in less rainfall and more frequent droughts. This view is most poignantly expressed by the saying: Man walks the earth and desert follows his steps! ... It is not surprising that under such circumstances the issue of a link between forests and climate has ... been addressed by governments. Lately, the Italian government has been paying special attention to reforestation in Italy and its expected improvement of the climate. ... It must be prevented that periods of heavy rainfall alternate with droughts. ...In the Unites States deforestation plays an important role as well and is seen as the cause for a reduction in rainfall. ... committee chairman of the American Association for Advancement of Science demands decisive steps to extend woodland in order to counteract the increasing drought. ... some serious concerns. In 1873, in Vienna, the congress for agriculture and forestry discussed the problem in detail; and when the Prussian house of representatives ordered a special commission to examine a proposed law pertaining to the preservation and implementation of forests for safeguarding, it pointed out that the steady decrease in the water levels of Prussian rivers was one of the most serious consequences of deforestation only to be rectified by reforestation programs. It is worth mentioning that ... the same concerns were raised in Russia as well and governmental circles reconsidered the issue of deforestation.

We have spent the best part of the past century enthusiastically testing the world to utter destruction; not looking closely enough at the long-term impact our actions will have.

We have very strong physical and chemical evidence for a large impact; this is the most firmly established part of the whole story. There is an unquestionable mass extinction at this time, and in the fossil groups for which we have the best record, the extinction coincides with the impact to a precision of a centimeter or better in the stratigraphic record. This exact coincidence in timing strongly argues for a causal relationship.

We live in a cultural milieu ... The idea that culture is our ecological niche is still applicable. The impact and force of natural selection on the human physique are conditioned by the dimensions of culture.

We, the people, still believe that our obligations as Americans are not just to ourselves, but to all posterity. We will respond to the threat of climate change, knowing that the failure to do so would betray our children and future generations. Some may still deny the overwhelming judgment of science, but none can avoid the devastating impact of raging fires and crippling drought and more powerful storms.

What Pasteur and Langmuir believed—and what history has shown—is that both epidemiologists and laboratory scientists can make independent discoveries that have significant scientific impact, but collaboration across these disciplines has a synergistic effect, yielding public health data that are stronger than either discipline can provide alone

While no one can ascribe a single weather event to climate change with any degree of scientific certainty, higher maximum temperatures are one of the most predictable impacts of accelerated global warming, and the parallels—between global climate change and global terrorism—are becoming increasingly obvious.

You cannot get through a single day without having an impact on the world around you. What you do makes a difference, and you have to decide what kind of difference you want to make.

You will never convince some palaeontologists that an impact killed the dinosaurs unless you find a dinosaur skeleton with a crushed skull and a ring of iridium round the hole.