Fundamental Quotes (122 quotes)
Dans les sciences physiques en général, on ait souvent supposé au lieu de conclure; que les suppositions transmises d’âge en âge, soient devenues de plus en plus imposantes par le poids des autorités qu'elles ont acquises , & qu'elles ayent enfin été adoptées & regardées comme des vérités fondamentales, même par de très-bons esprits.
In the science of physics in general, men have so often formed suppositions, instead of drawing conclusions. These suppositions, handed down from one age to another, acquire additional weight from the authorities by which they are supported, till at last they are received, even by men of genius, as fundamental truths.
In the science of physics in general, men have so often formed suppositions, instead of drawing conclusions. These suppositions, handed down from one age to another, acquire additional weight from the authorities by which they are supported, till at last they are received, even by men of genius, as fundamental truths.
A conflict arises when a religious community insists on the absolute truthfulness of all statements recorded in the Bible. This means an intervention on the part of religion into the sphere of science; this is where the struggle of the Church against the doctrines of Galileo and Darwin belongs. On the other hand, representatives of science have often made an attempt to arrive at fundamental judgments with respect to values and ends on the basis of scientific method, and in this way have set themselves in opposition to religion. These conflicts have all sprung from fatal errors.
A strong feeling of adventure is animating those who are working on bacterial viruses, a feeling that they have a small part in the great drive towards a fundamental problem in biology.
Acceptance without proof is the fundamental characteristic of Western religion, rejection without proof is the fundamental characteristic of Western science.
Again, it [the Analytical Engine] might act upon other things besides number, were objects found whose mutual fundamental relations could be expressed by those of the abstract science of operations, and which should be also susceptible of adaptations to the action of the operating notation and mechanism of the engine. Supposing for instance, that the fundamental relations of pitched sounds in the science of harmony and of musical composition were susceptible of such expression and adaptations, the engine might compose elaborate and scientific pieces of music of any degree of complexity or extent.
Although species may be discrete, they have no immutable essence. Variation is the raw material of evolutionary change. It represents the fundamental reality of nature, not an accident about a created norm. Variation is primary; essences are illusory. Species must be defined as ranges of irreducible variation.
Antiessentialist thinking forces us to view the world differently. We must accept shadings and continua as fundamental. We lose criteria for judgment by comparison to some ideal: short people, retarded people, people of other beliefs, colors, and religions are people of full status.
As agonizing a disease as cancer is, I do not think it can be said that our civilization is threatened by it. … But a very plausible case can be made that our civilization is fundamentally threatened by the lack of adequate fertility control. Exponential increases of population will dominate any arithmetic increases, even those brought about by heroic technological initiatives, in the availability of food and resources, as Malthus long ago realized.
As yet, if a man has no feeling for art he is considered narrow-minded, but if he has no feeling for science this is considered quite normal. This is a fundamental weakness.
But, as we consider the totality of similarly broad and fundamental aspects of life, we cannot defend division by two as a natural principle of objective order. Indeed, the ‘stuff’ of the universe often strikes our senses as complex and shaded continua, admittedly with faster and slower moments, and bigger and smaller steps, along the way. Nature does not dictate dualities, trinities, quarterings, or any ‘objective’ basis for human taxonomies; most of our chosen schemes, and our designated numbers of categories, record human choices from a cornucopia of possibilities offered by natural variation from place to place, and permitted by the flexibility of our mental capacities. How many seasons (if we wish to divide by seasons at all) does a year contain? How many stages shall we recognize in a human life?
Darwinian fitness is compounded of a mutual relationship between the organism and the environment. Of this, fitness of environment is quite as essential a component as the fitness which arises in the process of organic evolution; and in fundamental characteristics the actual environment is the fittest possible abode of life.
Einstein, twenty-six years old, only three years away from crude privation, still a patent examiner, published in the Annalen der Physik in 1905 five papers on entirely different subjects. Three of them were among the greatest in the history of physics. One, very simple, gave the quantum explanation of the photoelectric effect—it was this work for which, sixteen years later, he was awarded the Nobel prize. Another dealt with the phenomenon of Brownian motion, the apparently erratic movement of tiny particles suspended in a liquid: Einstein showed that these movements satisfied a clear statistical law. This was like a conjuring trick, easy when explained: before it, decent scientists could still doubt the concrete existence of atoms and molecules: this paper was as near to a direct proof of their concreteness as a theoretician could give. The third paper was the special eory of relativity, which quietly amalgamated space, time, and matter into one fundamental unity. This last paper contains no references and quotes no authority. All of them are written in a style unlike any other theoretical physicist's. They contain very little mathematics. There is a good deal of verbal commentary. The conclusions, the bizarre conclusions, emerge as though with the greatest of ease: the reasoning is unbreakable. It looks as though he had reached the conclusions by pure thought, unaided, without listening to the opinions of others. To a surprisingly large extent, that is precisely what he had done.
Everything which is new has to come out of fundamental research otherwise it’s not new.
Experiment is fundamentally only induced observation.
Faced with a new mutation in an organism, or a fundamental change in its living conditions, the biologist is frequently in no position whatever to predict its future prospects. He has to wait and see. For instance, the hairy mammoth seems to have been an admirable animal, intelligent and well-accoutered. Now that it is extinct, we try to understand why it failed. I doubt that any biologist thinks he could have predicted that failure. Fitness and survival are by nature estimates of past performance.
Fortunately I experienced Max Wertheimer's teaching in Berlin and collaborated for over a decade with Wolfgang Köhler. I need not emphasize my debts to these outstanding personalities. The fundamental ideas of Gestalt theory are the foundation of all our investigations in the field of the will, of affection, and of the personality.
Frequently, I have been asked if an experiment I have planned is pure or applied science; to me it is more important to know if the experiment will yield new and probably enduring knowledge about nature. If it is likely to yield such knowledge, it is, in my opinion, good fundamental research; and this is more important than whether the motivation is purely aesthetic satisfaction on the part of the experimenter on the one hand or the improvement of the stability of a high-power transistor on the other.
He who attempts to draw any conclusion whatever as to the nation's wealth or poverty from the mere fact of a favorable or unfavorable Balance of Trade, has not grasped the first fundamental principle of Political Economy.
I didn’t arrive at my understanding of the fundamental laws of the universe through my rational mind.
I do not see any reason to assume that the heuristic significance of the principle of general relativity is restricted to gravitation and that the rest of physics can be dealt with separately on the basis of special relativity, with the hope that later on the whole may be fitted consistently into a general relativistic scheme. I do not think that such an attitude, although historically understandable, can be objectively justified. The comparative smallness of what we know today as gravitational effects is not a conclusive reason for ignoring the principle of general relativity in theoretical investigations of a fundamental character. In other words, I do not believe that it is justifiable to ask: What would physics look like without gravitation?
I have no doubt that the fundamental problem the planet faces is the enormous increase in the human population. You see it overrunning everywhere. Places that were very remote when I went there 50 years ago are now overrun.
I like the word “nanotechnology.” I like it because the prefix “nano” guarantees it will be fundamental science for decades; the “technology” says it is engineering, something you’re involved in not just because you’re interested in how nature works but because it will produce something that has a broad impact.
I regard consciousness as fundamental. I regard matter as derivative from consciousness. We cannot get behind consciousness. Everything that we talk about, everything that we regard as existing, postulates consciousness.
I regret that it has been necessary for me in this lecture to administer such a large dose of four-dimensional geometry. I do not apologize, because I am really not responsible for the fact that nature in its most fundamental aspect is four-dimensional. Things are what they are; and it is useless to disguise the fact that “what things are” is often very difficult for our intellects to follow.
I suspect that the changes that have taken place during the last century in the average man's fundamental beliefs, in his philosophy, in his concept of religion. in his whole world outlook, are greater than the changes that occurred during the preceding four thousand years all put together. ... because of science and its applications to human life, for these have bloomed in my time as no one in history had had ever dreamed could be possible.
I think that intelligence does not emerge from a handful of very beautiful principles—like physics. It emerges from perhaps a hundred fundamentally different kinds of mechanisms that have to interact just right. So, even if it took only four years to understand them, it might take four hundred years to unscramble the whole thing.
If the observation of the amount of heat the sun sends the earth is among the most important and difficult in astronomical physics, it may also be termed the fundamental problem of meteorology, nearly all whose phenomena would become predictable, if we knew both the original quantity and kind of this heat.
If there be an order in which the human race has mastered its various kinds of knowledge, there will arise in every child an aptitude to acquire these kinds of knowledge in the same order. So that even were the order intrinsically indifferent, it would facilitate education to lead the individual mind through the steps traversed by the general mind. But the order is not intrinsically indifferent; and hence the fundamental reason why education should be a repetition of civilization in little.
If we go back to our chequer game, the fundamental laws are rules by which the chequers move. Mathematics may be applied in the complex situation to figure out what in given circumstances is a good move to make. But very little mathematics is needed for the simple fundamental character of the basic laws. They can be simply stated in English for chequers.
In a sense Shapley’s telling me that space was transparent, which I shouldn’t have believed, illustrates a fundamental problem in science, believing what people tell you. Go and find it out for yourself. That same error has persisted in my life and in many other people’s. Authorities are not always authorities on everything; they often cling to their own mistakes.
In medical practice a man may die when, scientifically speaking, he ought to have lived. I have actually known a man to die of a disease from which he was, scientifically speaking, immune. But that does not affect the fundamental truth of science.
In one of my lectures many years ago I used the phrase “following the trail of light”. The word “light” was not meant in its literal sense, but in the sense of following an intellectual concept or idea to where it might lead. My interest in living things is probably a fundamental motivation for the scientific work in the laboratory, and we created here in Berkeley one of the first and foremost interdisciplinary laboratories in the world.
It is a remarkable fact that the second law of thermodynamics has played in the history of science a fundamental role far beyond its original scope. Suffice it to mention Boltzmann’s work on kinetic theory, Planck’s discovery of quantum theory or Einstein’s theory of spontaneous emission, which were all based on the second law of thermodynamics.
It is evident, therefore, that one of the most fundamental problems of psychology is that of investigating the laws of mental growth. When these laws are known, the door of the future will in a measure be opened; determination of the child's present status will enable us to forecast what manner of adult he will become.
It is still false to conclude that man is nothing but the highest animal, or the most progressive product of organic evolution. He is also a fundamentally new sort of animal and one in which, although organic evolution continues on its way, a fundamentally new sort of evolution has also appeared. The basis of this new sort of evolution is a new sort of heredity, the inheritance of learning. This sort of heredity appears modestly in other mammals and even lower in the animal kingdom, but in man it has incomparably fuller development and it combines with man's other characteristics unique in degree with a result that cannot be considered unique only in degree but must also be considered unique in kind.
It is the constant attempt in this country [Canada] to make fundamental science responsive to the marketplace. Because technology needs science, it is tempting to require that scientific projects be justified in terms of the worth of the technology they can be expected to generate. The effect of applying this criterion is, however, to restrict science to developed fields where the links to technology are most evident. By continually looking for a short-term payoff we disqualify the sort of science that … attempts to answer fundamental questions, and, having answered them, suggests fundamentally new approaches in the realm of applications.
It seems as though no laws, not even fairly old ones, can safely be regarded as unassailable. The force of gravity, which we have always ascribed to the “pull of the earth,” was reinterpreted the other day by a scientist who says that when we fall it is not earth pulling us, it is heaven pushing us. This blasts the rock on which we sit. If science can do a rightabout-face on a thing as fundamental as gravity, maybe Newton was a sucker not to have just eaten the apple.
It would appear... that moral phenomena, when observed on a great scale, are found to resemble physical phenomena; and we thus arrive, in inquiries of this kind, at the fundamental principle, that the greater the number of individuals observed, the more do individual peculiarities, whether physical or moral, become effaced, and leave in a prominent point of view the general facts, by virtue of which society exists and is preserved.
It’s becoming clear that in a sense the cosmos provides the only laboratory where sufficiently extreme conditions are ever achieved to test new ideas on particle physics. The energies in the Big Bang were far higher than we can ever achieve on Earth. So by looking at evidence for the Big Bang, and by studying things like neutron stars, we are in effect learning something about fundamental physics.
Life is order, death is disorder. A fundamental law of Nature states that spontaneous chemical changes in the universe tend toward chaos. But life has, during milliards of years of evolution, seemingly contradicted this law. With the aid of energy derived from the sun it has built up the most complicated systems to be found in the universe—living organisms. Living matter is characterized by a high degree of chemical organisation on all levels, from the organs of large organisms to the smallest constituents of the cell. The beauty we experience when we enjoy the exquisite form of a flower or a bird is a reflection of a microscopic beauty in the architecture of molecules.
Most classifications, whether of inanimate objects or of organisms, are hierarchical. There are “higher” and “lower” categories, there are higher and lower ranks. What is usually overlooked is that the use of the term “hierarchy” is ambiguous, and that two fundamentally different kinds of arrangements have been designated as hierarchical. A hierarchy can be either exclusive or inclusive. Military ranks from private, corporal, sergeant, lieutenant, captain, up to general are a typical example of an exclusive hierarchy. A lower rank is not a subdivision of a higher rank; thus, lieutenants are not a subdivision of captains. The scala naturae, which so strongly dominated thinking from the sixteenth to the eighteenth century, is another good illustration of an exclusive hierarchy. Each level of perfection was considered an advance (or degradation) from the next lower (or higher) level in the hierarchy, but did not include it.
My decision to leave applied mathematics for economics was in part tied to the widely-held popular belief in the 1960s that macroeconomics had made fundamental inroads into controlling business cycles and stopping dysfunctional unemployment and inflation.
No other theory known to science [other than superstring theory] uses such powerful mathematics at such a fundamental level. …because any unified field theory first must absorb the Riemannian geometry of Einstein’s theory and the Lie groups coming from quantum field theory… The new mathematics, which is responsible for the merger of these two theories, is topology, and it is responsible for accomplishing the seemingly impossible task of abolishing the infinities of a quantum theory of gravity.
One of the most striking results of modern investigation has been the way in which several different and quite independent lines of evidence indicate that a very great event occurred about two thousand million years ago. The radio-active evidence for the age of meteorites; and the estimated time for the tidal evolution of the Moon's orbit (though this is much rougher), all agree in their testimony, and, what is far more important, the red-shift in the nebulae indicates that this date is fundamental, not merely in the history of our system, but in that of the material universe as a whole.
Only reason can convince us of those three fundamental truths without a recognition of which there can be no effective liberty: that what we believe is not necessarily true; that what we like is not necessarily good; and that all questions are open.
Pavlov’s data on the two fundamental antagonistic nervous processes—stimulation and inhibition—and his profound generalizations regarding them, in particular, that these processes are parts of a united whole, that they are in a state of constant conflict and constant transition of the one to the other, and his views on the dominant role they play in the formation of the higher nervous activity—all those belong to the most established natural—scientific validation of the Marxist dialectal method. They are in complete accord with the Leninist concepts on the role of the struggle between opposites in the evolution, the motion of matter.
Remarkably, only a handful of fundamental physical principles are sufficient to summarize most of modern physics.
Research is fundamentally a state of mind involving continual reexamination of doctrines and axioms upon which current thought and action are based. It is, therefore, critical of existing practices.
SCience is about paying attention to tiny things, and that’s how you end up uncovering the fundamental laws of nature.
Science is beautiful when it makes simple explanations of phenomena or connections between different observations. Examples include the double helix in biology, and the fundamental equations of physics.
[Answer to question: What are the things you find most beautiful in science?]
[Answer to question: What are the things you find most beautiful in science?]
Science, in the immediate, produces knowledge and, indirectly, means of action. It leads to methodical action if definite goals are set up in advance. For the function of setting up goals and passing statements of value transcends its domain. While it is true that science, to the extent of its grasp of causative connections, may reach important conclusions as to the compatibility and incompatibility of goals and evaluations, the independent and fundamental definitions regarding goals and values remain beyond science’s reach.
Scientists come in two varieties, hedgehogs and foxes. I borrow this terminology from Isaiah Berlin (1953), who borrowed it from the ancient Greek poet Archilochus. Archilochus told us that foxes know many tricks, hedgehogs only one. Foxes are broad, hedgehogs are deep. Foxes are interested in everything and move easily from one problem to another. Hedgehogs are only interested in a few problems that they consider fundamental, and stick with the same problems for years or decades. Most of the great discoveries are made by hedgehogs, most of the little discoveries by foxes. Science needs both hedgehogs and foxes for its healthy growth, hedgehogs to dig deep into the nature of things, foxes to explore the complicated details of our marvelous universe. Albert Einstein and Edwin Hubble were hedgehogs. Charley Townes, who invented the laser, and Enrico Fermi, who built the first nuclear reactor in Chicago, were foxes.
Technology can relieve the symptoms of a problem without affecting the underlying causes. Faith in technology as the ultimate solution to all problems can thus divert our attention from the most fundamental problem—the problem of growth in a finite system
That our being should consist of two fundamental elements [physical and psychical] offers I suppose no greater inherent improbability than that it should rest on one only.
The advances of biology during the past 20 years have been breathtaking, particularly in cracking the mystery of heredity. Nevertheless, the greatest and most difficult problems still lie ahead. The discoveries of the 1970‘s about the chemical roots of memory in nerve cells or the basis of learning, about the complex behavior of man and animals, the nature of growth, development, disease and aging will be at least as fundamental and spectacular as those of the recent past.
The argument of the ‘long view’ may be correct in some meaninglessly abstract sense, but it represents a fundamental mistake in categories and time scales. Our only legitimate long view extends to our children and our children’s children’s children–hundreds or a few thousands of years down the road. If we let the slaughter continue, they will share a bleak world with rats, dogs, cockroaches, pigeons, and mosquitoes. A potential recovery millions of years later has no meaning at our appropriate scale.
The body of science is not, as it is sometimes thought, a huge coherent mass of facts, neatly arranged in sequence, each one attached to the next by a logical string. In truth, whenever we discover a new fact it involves the elimination of old ones. We are always, as it turns out, fundamentally in error.
The concepts of ‘soul’ or ‘life’ do not occur in atomic physics, and they could not, even indirectly, be derived as complicated consequences of some natural law. Their existence certainly does not indicate the presence of any fundamental substance other than energy, but it shows only the action of other kinds of forms which we cannot match with the mathematical forms of modern atomic physics ... If we want to describe living or mental processes, we shall have to broaden these structures. It may be that we shall have to introduce yet other concepts.
The establishment of the periodic law may truly be said to mark a line in chemical science, and we anticipate that its application and and extension will be fraught With the most important consequences. It reminds us how important above all things is the correct determination of the fundamental constants of our science—the atomic weights of the elements, about which in many cases great uncertainty prevails; it is much to be desired that this may not long remain the case. It also affords the strongest encouragement to the chemist to persevere in the search for new elements.
The fairest thing we can experience is the mysterious. It is the fundamental emotion which stands at the cradle of true science. He who knows it not, and can no longer wonder, no longer feel amazement, is as good as dead. We all had this priceless talent when we were young. But as time goes by, many of us lose it. The true scientist never loses the faculty of amazement. It is the essence of his being.
The first concept of continental drift first came to me as far back as 1910, when considering the map of the world, under the direct impression produced by the congruence of the coast lines on either side of the Atlantic. At first I did not pay attention to the ideas because I regarded it as improbable. In the fall of 1911, I came quite accidentally upon a synoptic report in which I learned for the first time of palaeontological evidence for a former land bridge between Brazil and Africa. As a result I undertook a cursory examination of relevant research in the fields of geology and palaeontology, and this provided immediately such weighty corroboration that a conviction of the fundamental soundness of the idea took root in my mind.
The first fundamental rule of historical science and research, when by these is sought a knowledge of the general destinies of mankind, is to keep these and every object connected with them steadily in view, without losing ourselves in the details of special inquiries and particular facts, for the multitude and variety of these subjects is absolutely boundless; and on the ocean of historical science the main subject easily vanishes from the eye.
The framing of hypotheses is, for the enquirer after truth, not the end, but the beginning of his work. Each of his systems is invented, not that he may admire it and follow it into all its consistent consequences, but that he may make it the occasion of a course of active experiment and observation. And if the results of this process contradict his fundamental assumptions, however ingenious, however symmetrical, however elegant his system may be, he rejects it without hesitation. He allows no natural yearning for the offspring of his own mind to draw him aside from the higher duty of loyalty to his sovereign, Truth, to her he not only gives his affections and his wishes, but strenuous labour and scrupulous minuteness of attention.
The fundamental activity of medical science is to determine the ultimate causation of disease.
The fundamental biological variant is DNA. That is why Mendel's definition of the gene as the unvarying bearer of hereditary traits, its chemical identification by Avery (confirmed by Hershey), and the elucidation by Watson and Crick of the structural basis of its replicative invariance, are without any doubt the most important discoveries ever made in biology. To this must be added the theory of natural selection, whose certainty and full significance were established only by those later theories.
The fundamental characteristic of the scientific method is honesty. In dealing with any question, science asks no favors. ... I believe that constant use of the scientific method must in the end leave its impress upon him who uses it. ... A life spent in accordance with scientific teachings would be of a high order. It would practically conform to the teachings of the highest types of religion. The motives would be different, but so far as conduct is concerned the results would be practically identical.
The fundamental concept in social science is Power, in the same sense in which Energy is the fundamental concept in physics.
The fundamental essence of science, which I think we've lost in our education system, is poking something with a stick and seeing what happens. Embrace that process of inquiry.
The fundamental hypothesis of genetic epistemology is that there is a parallelism between the progress made in the logical and rational organization of knowledge and the corresponding formative psychological processes. With that hypothesis, the most fruitful, most obvious field of study would be the reconstituting of human history—the history of human thinking in prehistoric man. Unfortunately, we are not very well informed in the psychology of primitive man, but there are children all around us, and it is in studying children that we have the best chance of studying the development of logical knowledge, physical knowledge, and so forth.
The fundamental idea of these pylons, or great archways, is based on a method of construction peculiar to me, of which the principle consists in giving to the edges of the pyramid a curve of such a nature that this pyramid shall be capable of resisting the force of the wind without necessitating the junction of the edges by diagonals as is usually done.
[Writing of his tower after its completion in 1889.]
[Writing of his tower after its completion in 1889.]
The Fundamental Regulator Paradox … The task of a regulator is to eliminate variation, but this variation is the ultimate source of information about the quality of its work. Therefore, the better the job a regulator does the less information it gets about how to improve.
The history of the word sankhyā shows the intimate connection which has existed for more than 3000 years in the Indian mind between ‘adequate knowledge’ and ‘number.’ As we interpret it, the fundamental aim of statistics is to give determinate and adequate knowledge of reality with the help of numbers and numerical analysis. The ancient Indian word Sankhyā embodies the same idea, and this is why we have chosen this name for the Indian Journal of Statistics.
The mathematician is entirely free, within the limits of his imagination, to construct what worlds he pleases. What he is to imagine is a matter for his own caprice; he is not thereby discovering the fundamental principles of the universe nor becoming acquainted with the ideas of God. If he can find, in experience, sets of entities which obey the same logical scheme as his mathematical entities, then he has applied his mathematics to the external world; he has created a branch of science.
The moral faculties are generally and justly esteemed as of higher value than the intellectual powers. But we should bear in mind that the activity of the mind in vividly recalling past impressions is one of the fundamental though secondary bases of conscience. This affords the strongest argument for educating and stimulating in all possible ways the intellectual faculties of every human being.
The more important fundamental laws and facts of physical science have all been discovered, and these are now so firmly established that the possibility of their ever being supplanted in consequence of new discoveries is exceedingly remote.
The more important fundamental laws and facts of physical science have all been discovered, and these are now so firmly established that the possibility of their ever being supplanted in consequence of new discoveries is exceedingly remote. Nevertheless, it has been found that there are apparent exceptions to most of these laws, and this is particularly true when the observations are pushed to a limit, i.e., whenever the circumstances of experiment are such that extreme cases can be examined. Such examination almost surely leads, not to the overthrow of the law, but to the discovery of other facts and laws whose action produces the apparent exceptions. As instances of such discoveries, which are in most cases due to the increasing order of accuracy made possible by improvements in measuring instruments, may be mentioned: first, the departure of actual gases from the simple laws of the so-called perfect gas, one of the practical results being the liquefaction of air and all known gases; second, the discovery of the velocity of light by astronomical means, depending on the accuracy of telescopes and of astronomical clocks; third, the determination of distances of stars and the orbits of double stars, which depend on measurements of the order of accuracy of one-tenth of a second-an angle which may be represented as that which a pin's head subtends at a distance of a mile. But perhaps the most striking of such instances are the discovery of a new planet or observations of the small irregularities noticed by Leverrier in the motions of the planet Uranus, and the more recent brilliant discovery by Lord Rayleigh of a new element in the atmosphere through the minute but unexplained anomalies found in weighing a given volume of nitrogen. Many other instances might be cited, but these will suffice to justify the statement that “our future discoveries must be looked for in the sixth place of decimals.”
The more we split and pulverise matter artificially, the more insistently it proclaims its fundamental unity.
The most fundamental difference between compounds of low molecular weight and macromolecular compounds resides in the fact that the latter may exhibit properties that cannot be deduced from a close examination of the low molecular weight materials. Not very different structures can be obtained from a few building blocks; but if 10,000 or 100,000 blocks are at hand, the most varied structures become possible, such as houses or halls, whose special structure cannot be predicted from the constructions that are possible with only a few building blocks... Thus, a chromosome can be viewed as a material whose macromolecules possess a well defined arrangement, like a living room in which each piece of furniture has its place and not, as in a warehouse, where the pieces of furniture are placed together in a heap without design.
The nucleic acids, as constituents of living organisms, are comparable In importance to proteins. There is evidence that they are Involved In the processes of cell division and growth, that they participate In the transmission of hereditary characters, and that they are important constituents of viruses. An understanding of the molecular structure of the nucleic acids should be of value In the effort to understand the fundamental phenomena of life.
[Co-author with American chemist, B. Corey (1897-1971)]
[Co-author with American chemist, B. Corey (1897-1971)]
The physiological combustion theory takes as its starting point the fundamental principle that the amount of heat that arises from the combustion of a given substance is an invariable quantity–i.e., one independent of the circumstances accompanying the combustion–from which it is more specifically concluded that the chemical effect of the combustible materials undergoes no quantitative change even as a result of the vital process, or that the living organism, with all its mysteries and marvels, is not capable of generating heat out of nothing.
The preservation of a few samples of undeveloped territory is one of the most clamant issues before us today. Just a few more years of hesitation and the only trace of that wilderness which has exerted such a fundamental influence in molding American character will lie in the musty pages of pioneer books. … To avoid this catastrophe demands immediate action.
The scientific value of truth is not, however, ultimate or absolute. It rests partly on practical, partly on aesthetic interests. As our ideas are gradually brought into conformity with the facts by the painful process of selection,—for intuition runs equally into truth and into error, and can settle nothing if not controlled by experience,—we gain vastly in our command over our environment. This is the fundamental value of natural science
The student of biology is often struck with the feeling that historians, when dealing with the rise and fall of nations, do not generally view the phenomena from a sufficiently high biological standpoint. To me, at least, they seem to attach too much importance to individual rulers and soldiers, and to particular wars, policies, religions, and customs; while at the same time they make little attempt to extract the fundamental causes of national success or failure.
The study of the radio-active substances and of the discharge of electricity through gases has supplied very strong experimental evidence in support of the fundamental ideas of the existing atomic theory. It has also indicated that the atom itself is not the smallest unit of matter, but is a complicated structure made up of a number of smaller bodies.
The suppression of uncomfortable ideas may be common in religion or in politics, but it is not the path to knowledge; it has no in the endeavor of science. We do not know in advance who will discover fundamental insights.
The symbol A is not the counterpart of anything in familiar life. To the child the letter A would seem horribly abstract; so we give him a familiar conception along with it. “A was an Archer who shot at a frog.” This tides over his immediate difficulty; but he cannot make serious progress with word-building so long as Archers, Butchers, Captains, dance round the letters. The letters are abstract, and sooner or later he has to realise it. In physics we have outgrown archer and apple-pie definitions of the fundamental symbols. To a request to explain what an electron really is supposed to be we can only answer, “It is part of the A B C of physics”.
The transition from a paradigm in crisis to a new one from which a new tradition of normal science can emerge is far from a cumulative process, one achieved by an articulation or extension of the old paradigm. Rather it is a reconstruction of the field from new fundamentals, a reconstruction that changes some of the field's most elementary theoretical generalizations as well as many of its paradigm methods and applications. During the transition period there will be a large but never complete overlap between the problems that can be solved by the old and by the new paradigm. But there will also be a decisive difference in the modes of solution. When the transition is complete, the profession will have changed its view of the field, its methods, and its goals.
The trend of mathematics and physics towards unification provides the physicist with a powerful new method of research into the foundations of his subject. … The method is to begin by choosing that branch of mathematics which one thinks will form the basis of the new theory. One should be influenced very much in this choice by considerations of mathematical beauty. It would probably be a good thing also to give a preference to those branches of mathematics that have an interesting group of transformations underlying them, since transformations play an important role in modern physical theory, both relativity and quantum theory seeming to show that transformations are of more fundamental importance than equations.
The velocity of light is one of the most important of the fundamental constants of Nature. Its measurement by Foucault and Fizeau gave as the result a speed greater in air than in water, thus deciding in favor of the undulatory and against the corpuscular theory. Again, the comparison of the electrostatic and the electromagnetic units gives as an experimental result a value remarkably close to the velocity of light–a result which justified Maxwell in concluding that light is the propagation of an electromagnetic disturbance. Finally, the principle of relativity gives the velocity of light a still greater importance, since one of its fundamental postulates is the constancy of this velocity under all possible conditions.
The vigorous branching of life’s tree, and not the accumulating valor of mythical marches to progress, lies behind the persistence and expansion of organic diversity in our tough and constantly stressful world. And if we do not grasp the fundamental nature of branching as the key to life’s passage across the geological stage, we will never understand evolution aright.
The year 1896 ... marked the beginning of what has been aptly termed the heroic age of Physical Science. Never before in the history of physics has there been witnessed such a period of intense activity when discoveries of fundamental importance have followed one another with such bewildering rapidity.
The ‘mad idea’ which will lie at the basis of a future fundamental physical theory will come from a realization that physical meaning has some mathematical form not previously associated with reality. From this point of view the problem of the ‘mad idea’ is the problem of choosing, not of generating, the right idea. One should not understand that too literally. In the 1960s it was said (in a certain connection) that the most important discovery of recent years in physics was the complex numbers. The author [Yuri Manin] has something like that in mind.
There has been no discovery like it in the history of man. It puts into man's hands the key to using the fundamental energy of the universe.
There is a reward structure in science that is very interesting: Our highest honors go to those who disprove the findings of the most revered among us. So Einstein is revered not just because he made so many fundamental contributions to science, but because he found an imperfection in the fundamental contribution of Isaac Newton.
There is no fundamental difference between man and the higher animals in their mental faculties ... The lower animals, like man, manifestly feel pleasure and pain, happiness, and misery.
There is no inductive method which could lead to the fundamental concepts of physics. Failure to understand this fact constituted the basic philosophical error of so many investigators of the nineteenth century.
This fundamental discovery that all bodies owe their origin to arrangements of single initial corpuscular type is the beacon that lights the history of the universe to our eyes. In its own way, matter obeyed from the beginning that great law of biology to which we shall have to recur time and time again, the law of “complexification.”
This is the reason why all attempts to obtain a deeper knowledge of the foundations of physics seem doomed to me unless the basic concepts are in accordance with general relativity from the beginning. This situation makes it difficult to use our empirical knowledge, however comprehensive, in looking for the fundamental concepts and relations of physics, and it forces us to apply free speculation to a much greater extent than is presently assumed by most physicists.
Though much new light is shed by ... studies in radioactivity, the nucleus of the atom, with its hoard of energy, thus continues to present us with a fascinating mystery. ... Our assault on atoms has broken down the outer fortifications. We feel that we know the fundamental rules according to which the outer part of the atom is built. The appearance and properties of the electron atmosphere are rather familiar. Yet that inner citadel, the atomic nucleus, remains unconquered, and we have reason to believe that within this citadel is secreted a great treasure. Its capture may form the main objective of the physicists’ next great drive.
Touch is the most fundamental sense. A baby experiences it, all over, before he is born and long before he learns to use sight, hearing, or taste, and no human ever ceases to need it.
Typical of the fundamental scientific problems whose solution should lead to important industrial consequences are, for example, the release of atomic energy, which experiment has shown to exist in quantities millions of times greater than is liberated by combustion.
We are very lucky to be living in an age in which we are still making discoveries. It is like the discovery of America—you only discover it once. The age in which we live is the age in which we are discovering the fundamental laws of nature, and that day will never come again. It is very exciting, it is marvelous, but this excitement will have to go.
We build our personalities laboriously and through many years, and we cannot order fundamental changes just because we might value their utility; no button reading ‘positive attitude’ protrudes from our hearts, and no finger can coerce positivity into immediate action by a single and painless pressing.
We don't know what we are talking about. Many of us believed that string theory was a very dramatic break with our previous notions of quantum theory. But now we learn that string theory, well, is not that much of a break. The state of physics today is like it was when we were mystified by radioactivity. They were missing something absolutely fundamental. We are missing perhaps something as profound as they were back then.
We have not done the things that are necessary to lower emissions because these things fundamentally conflict with deregulated capitalism… We are stuck because the actions that would give us the best chance of averting catastrophe–and would benefit the vast majority–are extremely threatening to an elite minority that has a stranglehold over our economy, our political process, and most of our major media outlets.
We lay down a fundamental principle of generalization by abstraction: The existence of analogies between central features of various theories implies the existence of a general theory which underlies the particular theories and unifies them with respect to those central features.
We live in a capitalist economy, and I have no particular objection to honorable self-interest. We cannot hope to make the needed, drastic improvement in primary and secondary education without a dramatic restructuring of salaries. In my opinion, you cannot pay a good teacher enough money to recompense the value of talent applied to the education of young children. I teach an hour or two a day to tolerably well-behaved near-adults–and I come home exhausted. By what possible argument are my services worth more in salary than those of a secondary-school teacher with six classes a day, little prestige, less support, massive problems of discipline, and a fundamental role in shaping minds. (In comparison, I only tinker with intellects already largely formed.)
We make a lot of mistakes in the environmental space. … We don't do a good-enough job of asking, “What are the fundamentals of telling a good story?” And that is not statistics, it's usually not science, or at least complex science. It's people stories. … It’s got to have adventure, it’s got to be funny, it’s got to pull my heart strings, it’s got to have conflict, setting, character. It’s a story. And if it doesn’t have those things, it can be the best-meaning story in the world, and nobody's going to buy it.
We may be well be justified in saying that quantum theory is of greater importance to chemistry than physics. For where there are large fields of physics that can be discussed in a completely penetrating way without reference to Planck's constant and to quantum theory at all, there is no part of chemistry that does not depend, in its fundamental theory, upon quantum principles.
We set out, therefore, with the supposition that an organised body is not produced by a fundamental power which is guided in its operation by a definite idea, but is developed, according to blind laws of necessity, by powers which, like those of inorganic nature, are established by the very existence of matter. As the elementary materials of organic nature are not different from those of the inorganic kingdom, the source of the organic phenomena can only reside in another combination of these materials, whether it be in a peculiar mode of union of the elementary atoms to form atoms of the second order, or in the arrangement of these conglomerate molecules when forming either the separate morphological elementary parts of organisms, or an entire organism.
What made von Liebig and his students “different” from other chemists was their effort to apply their fundamental discoveries to the development of specific chemical processes and products.
What must be an essential feature of any future fundamental physics?
What of the future of this adventure? What will happen ultimately? We are going along guessing the laws; how many laws are we going to have to guess? I do not know. Some of my colleagues say that this fundamental aspect of our science will go on; but I think there will certainly not be perpetual novelty, say for a thousand years. This thing cannot keep on going so that we are always going to discover more and more new laws … It is like the discovery of America—you only discover it once. The age in which we live is the age in which we are discovering the fundamental laws of nature, and that day will never come again. Of course in the future there will be other interests … but there will not be the same things that we are doing now … There will be a degeneration of ideas, just like the degeneration that great explorers feel is occurring when tourists begin moving in on a territory.
When I received my B.S. degree in 1932, only two of the fundamental particles of physics were known. Every bit of matter in the universe was thought to consist solely of protons and electrons.
When I was in college studying science, I found the experience fundamentally unsatisfying. I was continually oppressed by the feeling that my only role was to “shut up and learn.” I felt there was nothing I could say to my instructors that they would find interesting. … As I sat in the science lecture hall, I was utterly silent. That’s not a good state to be in when you are 19 years old.
When rich men are thus brought to regard themselves as trustees, and poor men learn to be industrious, economical, temperate, self-denying, and diligent in the acquisition of knowledge, then the deplorable strife between capital and labor, tending to destroy their fundamental, necessary, and irrefragable harmony will cease, and the world will no longer be afflicted with such unnatural industrial conflicts as we have seen during the past century...
When you are criticizing the philosophy of an epoch do not chiefly direct your attention to these intellectual positions which its exponents feel it necessary to defend. There will be some fundamental assumption which adherents of all the various systems of the epoch unconsciously presuppose.
[About research with big particle accelerators such as the Large Hadron Collider.] I think the primary justification for this sort of science that we do is fundamental human curiosity. ... It's true, of course, that every previous generation that's made some breakthrough in understanding nature has seen those discoveries translated into new technologies, new possibilities for the human race. That may well happen with the Higgs boson. Quite frankly, at the moment I don't see how you can use the Higgs boson for anything useful.
[Certain students] suppose that because science has penetrated the structure of the atom it can solve all the problems of the universe. ... They are known in every ... college as the most insufferable, cocksure know-it-alls. If you want to talk to them about poetry, they are likely to reply that the "emotive response" to poetry is only a conditioned reflex .... If they go on to be professional scientists, their sharp corners are rubbed down, but they undergo no fundamental change. They most decidedly are not set apart from the others by their intellectual integrity and faith, and their patient humility in front of the facts of nature.... They are uneducated, in the fullest sense of the word, and they certainly are no advertisement for the claims of science teachers.
[Receiving a university scholarship] was fundamentally important to me, to be able to afford going to school, and I still believe so strongly in the value of public education and state-funded universities.
[The] second fundamental rule of historical science may be thus simply expressed:—we should not wish to explain every thing. Historical tradition must never be abandoned in the philosophy of history—otherwise we lose all firm ground and footing. But historical tradition, ever so accurately conceived and carefully sifted, doth not always, especially in the early and primitive ages, bring with it a full and demonstrative certainty.
[T]he history of science has proved that fundamental research is the lifeblood of individual progress and that the ideas that lead to spectacular advances spring from it.