… on these expanded membranes [butterfly wings] Nature writes, as on a tablet, the story of the modifications of species, so truly do all changes of the organisation register themselves thereon. Moreover, the same colour-patterns of the wings generally show, with great regularity, the degrees of blood-relationship of the species. As the laws of nature must be the same for all beings, the conclusions furnished by this group of insects must be applicable to the whole world.

...travel is more than the seeing of sights; it is a change that goes on, deep and permanent, in the ideas of living.

“And how many hours a day did you do lessons?” said Alice, in a hurry to change the subject.
“Ten hours the first day,” said the Mock Turtle: “nine the next, and so on.”
“What a curious plan!” exclaimed Alice.
“That's the reason they’re called lessons,” the Gryphon remarked: “because they lessen from day to day.”

“Conservation” (the conservation law) means this … that there is a number, which you can calculate, at one moment—and as nature undergoes its multitude of changes, this number doesn't change. That is, if you calculate again, this quantity, it'll be the same as it was before. An example is the conservation of energy: there's a quantity that you can calculate according to a certain rule, and it comes out the same answer after, no matter what happens, happens.

“I’m not so sure he’s wrong about automobiles,” he said, “With all their speed forward they may be a step backward for civilization—that is, spiritual civilization … But automobiles have come, and they bring a greater change in our life than most of us expect. They are here, and almost all outward things are going to be different because of what they bring. They are going to alter war, and they are going to alter peace.”

“One and one make two” assumes that the changes in the shift of circumstance are unimportant. But it is impossible for us to analyze this notion of unimportant change.

“These changes in the body,” he wrote in the review paper he sent to the American Journal of Physiology late in 1913, “are, each one of them, directly serviceable in making the organism more efficient in the struggle which fear or rage or pain may involve; for fear and rage are organic preparations for action, and pain is the most powerful known stimulus to supreme exertion. The organism which with the aid of increased adrenal secretion can best muster its energies, can best call forth sugar to supply the labouring muscles, can best lessen fatigue, and can best send blood to the parts essential in the run or the fight for life, is most likely to survive. Such, according to the view here propounded, is the function of the adrenal medulla at times of great emergency.”

(1) I have told you more than I know about osteoporosis. (2) What I have told you is subject to change without notice. (3) I hope I raised more questions than I have given answers. (4) In any case, as usual, a lot more work is necessary.
Conclusion of one of his papers.

[1665-08-16] ...Hence to the Exchange, which I have not been a great while. But Lord, how sad a sight it is to see the streets empty of people, and very few upon the Change - jealous of every door that one sees shut up, lest it should be the plague - and about us, two shops in three, if not more, generally shut up. ... It was dark before I could get home; and so land at church-yard stairs, where to my great trouble I met a dead Corps, of the plague, in the narrow ally, just bringing down a little pair of stairs - but I thank God I was not much disturbed at it. However, I shall beware of being late abroad again.

[A dragonfly larva is] carrying inside it two entirely separate blueprints, two different programmes [to turn into a dragonfly].

[A plant] does not change itself gradually, but remains unaffected during all succeeding generations. It only throws off new forms, which are sharply contrasted with the parent, and which are from the very beginning as perfect and as constant, as narrowly defined, and as pure of type as might be expected of any species.

[Certain students] suppose that because science has penetrated the structure of the atom it can solve all the problems of the universe. ... They are known in every ... college as the most insufferable, cocksure know-it-alls. If you want to talk to them about poetry, they are likely to reply that the "emotive response" to poetry is only a conditioned reflex .... If they go on to be professional scientists, their sharp corners are rubbed down, but they undergo no fundamental change. They most decidedly are not set apart from the others by their intellectual integrity and faith, and their patient humility in front of the facts of nature.... They are uneducated, in the fullest sense of the word, and they certainly are no advertisement for the claims of science teachers.

[Defining Life] The definite combination of heterogeneous changes, both simultaneous and successive, in correspondence with external co-existences and sequences.

[For the] increase of knowledge and … the useful application of the knowledge gained, … there never is a sudden beginning; even the cloud change which portends the thunderstorm begins slowly.

[Geology] may be looked upon as the history of the earth’s changes during preparation for the reception of organized beings, a history, which has all the character of a great epic.

[It] is the little causes, long continued, which are considered as bringing about the greatest changes of the earth.

[Mercurial medicines] affect the human constitution in a peculiar manner, taking, so to speak, an iron grasp of all its systems, and penetrating even to the bones, by which they not only change the healthy action of its vessels, and general structure, but greatly impair and destroy its energies; so that their abuse is rarely overcome. When the tone of the stomach, intestines, or nervous system generally, has been once injured by this mineral ... it could seldom be restored.

[My advice] will one day be found
With other relics of 'a former world,'
When this world shall be former, underground,
Thrown topsy-turvy, twisted, crisped, and curled,
Baked, fried or burnt, turned inside-out, or drowned,
Like all the worlds before, which have been hurled
First out of, and then back again to Chaos,
The Superstratum which will overlay us.

[My favourite fellow of the Royal Society is the Reverend Thomas Bayes, an obscure 18th-century Kent clergyman and a brilliant mathematician who] devised a complex equation known as the Bayes theorem, which can be used to work out probability distributions. It had no practical application in his lifetime, but today, thanks to computers, is routinely used in the modelling of climate change, astrophysics and stock-market analysis.

[O]ur long-term security is threatened by a problem at least as dangerous as chemical, nuclear or biological weapons, or indeed international terrorism: human-induced climate change. … The impacts of global warming are such that I have no hesitation in describing it as a “weapon of mass destruction.” Like terrorism, this weapon knows no boundaries. It can strike anywhere, in any form…

[The chemical bond] First, it is related to the disposition of two electrons (remember, no one has ever seen an electron!): next, these electrons have their spins pointing in opposite directions (remember, no one can ever measure the spin of a particular electron!): then, the spatial distribution of these electrons is described analytically with some degree of precision (remember, there is no way of distinguishing experimentally the density distribution of one electron from another!): concepts like hybridization, covalent and ionic structures, resonance, all appear, not one of which corresponds to anything that is directly measurable. These concepts make a chemical bond seem so real, so life-like, that I can almost see it. Then I wake with a shock to the realization that a chemical bond does not exist; it is a figment of the imagination that we have invented, and no more real than the square root of - 1. I will not say that the known is explained in terms of the unknown, for that is to misconstrue the sense of intellectual adventure. There is no explanation: there is form: there is structure: there is symmetry: there is growth: and there is therefore change and life.

[The Royal Society] is quite simply the voice of science in Britain. It is intellectually rigorous, not afraid to be outspoken on controversial issues such as climate change, but it is not aggressively secular either, insisting on a single view of the world. In fact, there are plenty of eminent scientists – Robert Winston, for instance – who are also men of faith.

[To the cultures of Asia and the continent of Africa] it is the Western impact which has stirred up the winds of change and set the processes of modernization in motion. Education brought not only the idea of equality but also another belief which we used to take for granted in the West—the idea of progress, the idea that science and technology can be used to better human conditions. In ancient society, men tended to believe themselves fortunate if tomorrow was not worse than today and anyway, there was little they could do about it.

“Pieces” almost always appear 'as parts' in whole processes. ... To sever a “'part” from the organized whole in which it occurs—whether it itself be a subsidiary whole or an “element”—is a very real process usually involving alterations in that “part”. Modifications of a part frequently involve changes elsewhere in the whole itself. Nor is the nature of these alterations arbitrary, for they too are determined by whole-conditions.

[On the propulsive force of rockets] One part of fire takes up as much space as ten parts of air, and one part of air takes up the space of ten parts of water, and one part of water as much as ten parts of earth. Now powder is earth, consisting of the four elementary principles, and when the sulfur conducts the fire into the dryest part of the powder, fire, and air increase … the other elements also gird themselves for battle with each other and the rage of battle is changed by their heat and moisture into a strong wind.

Air Chief Marshal Harris [objecting to a change in strategy recommended by statisticians]: Are we fighting this war with weapons or the slide rule?
Churchill [after puffing on his cigar]: That's a good idea. Let's try the slide rule.

Dauer in Wechsel.
Duration in change.

Discovery always carries an honorific connotation. It is the stamp of approval on a finding of lasting value. Many laws and theories have come and gone in the history of science, but they are not spoken of as discoveries. Kepler is said to have discovered the laws of planetary motion named after him, but no the many other 'laws' which he formulated. ... Theories are especially precarious, as this century profoundly testifies. World views can and do often change. Despite these difficulties, it is still true that to count as a discovery a finding must be of at least relatively permanent value, as shown by its inclusion in the generally accepted body of scientific knowledge.

~~[Orphan]~~ If the facts don’t fit the theory, change the facts.

~~[Questionable attribution]~~ Travel and change of place impart new vigor to the mind.

A ... hypothesis may be suggested, which supposes the word 'beginning' as applied by Moses in the first of the Book of Genesis, to express an undefined period of time which was antecedent to the last great change that affected the surface of the earth, and to the creation of its present animal and vegetable inhabitants; during which period a long series of operations and revolutions may have been going on, which, as they are wholly unconnected with the history of the human race, are passed over in silence by the sacred historian, whose only concern with them was largely to state, that the matter of the universe is not eternal and self-existent but was originally created by the power of the Almighty.

A “pacifist male” is a contradiction in terms. Most self-described “pacifists” are not pacific; they simply assume false colors. When the wind changes, they hoist the Jolly Roger.

A chemical compound once formed would persist for ever, if no alteration took place in surrounding conditions. But to the student of Life the aspect of nature is reversed. Here, incessant, and, so far as we know, spontaneous change is the rule, rest the exception—the anomaly to be accounted for. Living things have no inertia and tend to no equilibrium.

A comparison between the triplets tentatively deduced by these methods with the changes in amino acid sequence produced by mutation shows a fair measure of agreement.

A distinguished writer [Siméon Denis Poisson] has thus stated the fundamental definitions of the science:
“The probability of an event is the reason we have to believe that it has taken place, or that it will take place.”
“The measure of the probability of an event is the ratio of the number of cases favourable to that event, to the total number of cases favourable or contrary, and all equally possible” (equally like to happen).
From these definitions it follows that the word probability, in its mathematical acceptation, has reference to the state of our knowledge of the circumstances under which an event may happen or fail. With the degree of information which we possess concerning the circumstances of an event, the reason we have to think that it will occur, or, to use a single term, our expectation of it, will vary. Probability is expectation founded upon partial knowledge. A perfect acquaintance with all the circumstances affecting the occurrence of an event would change expectation into certainty, and leave neither room nor demand for a theory of probabilities.

A great ball of fire about a mile in diameter, changing colors as it kept shooting upward, from deep purple to orange, expanding, growing bigger, rising as it was expanding, an elemental force freed from its bonds after being chained for billions of years.
On the first atomic explosion in New Mexico, 16 Jul 1945.

A human being should be able to change a diaper, plan an invasion, butcher a hog, conn a ship, design a building, write a sonnet, balance accounts, build a wall, set a bone, comfort the dying, take orders, give orders, cooperate, act alone, solve equations, analyze a new problem, pitch manure, program a computer, cook a tasty meal, fight efficiently, die gallantly. Specialization is for insects.

A man with a conviction is a hard man to change. Tell him you disagree and he turns away. Show him facts or figures and he questions your sources. Appeal to logic and he fails to see your point.

A recognized fact which goes back to the earliest times is that every living organism is not the sum of a multitude of unitary processes, but is, by virtue of interrelationships and of higher and lower levels of control, an unbroken unity. When research, in the efforts of bringing understanding, as a rule examines isolated processes and studies them, these must of necessity be removed from their context. In general, viewed biologically, this experimental separation involves a sacrifice. In fact, quantitative findings of any material and energy changes preserve their full context only through their being seen and understood as parts of a natural order.

A scientist is a man who changes his beliefs according to reality; a theist is a man who changes reality to match his beliefs.

A single ray of light from a distant star falling upon the eye of a tyrant in bygone times, may have altered the course of his life, may have changed the destiny of nations, may have transformed the surface of the globe, so intricate, so inconceivably complex are the processes of nature.

A sound Physics of the Earth should include all the primary considerations of the earth's atmosphere, of the characteristics and continual changes of the earth's external crust, and finally of the origin and development of living organisms. These considerations naturally divide the physics of the earth into three essential parts, the first being a theory of the atmosphere, or Meteorology, the second, a theory of the earth's external crust, or Hydrogeology, and the third, a theory of living organisms, or Biology.

A State without the means of some change is without the means of its conservation.

A weapon is a device for making your enemy change his mind.

A word is not a crystal, transparent and unchanged, it is the skin of a living thought and may vary greatly in color and content according to the circumstances and the time in which it is used.

Above, far above the prejudices and passions of men soar the laws of nature. Eternal and immutable, they are the expression of the creative power they represent what is, what must be, what otherwise could not be. Man can come to understand them: he is incapable of changing them.

According to my derivative hypothesis, a change takes place first in the structure of the animal, and this, when sufficiently advanced, may lead to modifications of habits… . “Derivation” holds that every species changes, in time, by virtue of inherent tendencies thereto. “Natural Selection” holds that no such change can take place without the influence of altered external circumstances educing or selecting such change… . The hypothesis of “natural selection” totters on the extension of a conjectural condition, explanatory of extinction to the majority of organisms, and not known or observed to apply to the origin of any species.

Adrenalin does not excite sympathetic ganglia when applied to them directly, as does nicotine. Its effective action is localised at the periphery. The existence upon plain muscle of a peripheral nervous network, that degenerates only after section of both the constrictor and inhibitory nerves entering it, and not after section of either alone, has been described. I find that even after such complete denervation, whether of three days' or ten months' duration, the plain muscle of the dilatator pupillae will respond to adrenalin, and that with greater rapidity and longer persistence than does the iris whose nervous relations are uninjured. Therefore it cannot be that adrenalin excites any structure derived from, and dependent for its persistence on, the peripheral neurone. But since adrenalin does not evoke any reaction from muscle that has at no time of its life been innervated by the sympathetic, the point at which the stimulus of the chemical excitant is received, and transformed into what may cause the change of tension of the muscle fibre, is perhaps a mechanism developed out of the muscle cell in response to its union with the synapsing sympathetic fibre, the function of which is to receive and transform the nervous impulse. Adrenalin might then be the chemical stimulant liberated on each occasion when the impulse arrives at the periphery.

Alike in the external and the internal worlds, the man of science sees himself in the midst of perpetual changes of which he can discover neither the beginning nor the end.

All change is relative. The universe is expanding relatively to our common material standards; our material standards are shrinking relatively to the size of the universe. The theory of the “expanding universe” might also be called the theory of the “shrinking atom”. …
:Let us then take the whole universe as our standard of constancy, and adopt the view of a cosmic being whose body is composed of intergalactic spaces and swells as they swell. Or rather we must now say it keeps the same size, for he will not admit that it is he who has changed. Watching us for a few thousand million years, he sees us shrinking; atoms, animals, planets, even the galaxies, all shrink alike; only the intergalactic spaces remain the same. The earth spirals round the sun in an ever-decreasing orbit. It would be absurd to treat its changing revolution as a constant unit of time. The cosmic being will naturally relate his units of length and time so that the velocity of light remains constant. Our years will then decrease in geometrical progression in the cosmic scale of time. On that scale man’s life is becoming briefer; his threescore years and ten are an ever-decreasing allowance. Owing to the property of geometrical progressions an infinite number of our years will add up to a finite cosmic time; so that what we should call the end of eternity is an ordinary finite date in the cosmic calendar. But on that date the universe has expanded to infinity in our reckoning, and we have shrunk to nothing in the reckoning of the cosmic being.
We walk the stage of life, performers of a drama for the benefit of the cosmic spectator. As the scenes proceed he notices that the actors are growing smaller and the action quicker. When the last act opens the curtain rises on midget actors rushing through their parts at frantic speed. Smaller and smaller. Faster and faster. One last microscopic blurr of intense agitation. And then nothing.

All frescoes are as high finished as miniatures or enamels, and they are known to be unchangeable; but oil, being a body itself, will drink or absorb very little colour, and changing yellow, and at length brown, destroys every colour it is mixed with, especially every delicate colour. It turns every permanent white to a yellow and brown putty, and has compelled the use of that destroyer of colour, white lead, which, when its protecting oil is evaporated, will become lead again. This is an awful thing to say to oil painters ; they may call it madness, but it is true. All the genuine old little pictures, called cabinet pictures, are in fresco and not in oil. Oil was not used except by blundering ignorance till after Vandyke’s time ; but the art of fresco painting being lost, oil became a fetter to genius and a dungeon to art.

All interpretations made by a scientist are hypotheses, and all hypotheses are tentative. They must forever be tested and they must be revised if found to be unsatisfactory. Hence, a change of mind in a scientist, and particularly in a great scientist, is not only not a sign of weakness but rather evidence for continuing attention to the respective problem and an ability to test the hypothesis again and again.

All parts of the material universe are in constant motion and though some of the changes may appear to be cyclical, nothing ever exactly returns, so far as human experience extends, to precisely the same condition.

All scientific theories are provisional and may be changed, but ... on the whole, they are accepted from Washington to Moscow because of their practical success. Where religion has opposed the findings of science, it has almost always had to retreat.

All substances susceptible of decay, when in a moist state, and exposed to the air and light at the common temperature, undergo precisely the same change as they would if exposed to a red-heat, in a dry state, that is, they absorb oxygen,—they undergo combustion.

All the life of the universe may be regarded as manifestations of energy masquerading in various forms, and all the changes in the universe as energy running about from one of these forms to the other, but always without altering the total amount.

All the more recent work on alkaptonuria has... strengthened the belief that the homogentisic acid excreted is derived from tyrosin, but why alkaptonuric individuals pass the benzene ring of their tyrosin unbroken and how and where the peculiar chemical change from tyrosin to homogentisic acid is brought about, remain unsolved problems.

All things on the earth are the result of chemical combination. The operation by which the commingling of molecules and the interchange of atoms take place we can imitate in our laboratories; but in nature they proceed by slow degrees, and, in general, in our hands they are distinguished by suddenness of action. In nature chemical power is distributed over a long period of time, and the process of change is scarcely to be observed. By acts we concentrate chemical force, and expend it in producing a change which occupies but a few hours at most.

Almost always the men who achieve these fundamental inventions of a new paradigm have been either very young or very new to the field whose paradigm they change.

Although a physical law may never admit of a perfectly abrupt change, there is no limit to the approach which it may make to abruptness.

Although few expressions are more commonly used in writing about science than “science revolution,” there is a continuing debate as to the propriety of applying the concept and term “revolution” to scientific change. There is, furthermore, a wide difference of opinion as to what may constitute a revolution. And although almost all historians would agree that a genuine alteration of an exceptionally radical nature (the Scientific Revolution) occurred in the sciences at some time between the late fifteenth (or early sixteenth) century and the end of the seventeenth century, the question of exactly when this revolution occurred arouses as much scholarly disagreement as the cognate question of precisely what it was.

Although species may be discrete, they have no immutable essence. Variation is the raw material of evolutionary change. It represents the fundamental reality of nature, not an accident about a created norm. Variation is primary; essences are illusory. Species must be defined as ranges of irreducible variation.

Amid all the revolutions of the globe, the economy of Nature has been uniform, ... and her laws are the only things that have resisted the general movement. The rivers and the rocks, the seas and the continents, have been changed in all their parts; but the laws which direct those changes, and the rules to which they are subject, have remained invariably the same.

Among the authorities it is generally agreed that the Earth is at rest in the middle of the universe, and they regard it as inconceivable and even ridiculous to hold the opposite opinion. However, if we consider it more closely the question will be seen to be still unsettled, and so decidedly not to be despised. For every apparent change in respect of position is due to motion of the object observed, or of the observer, or indeed to an unequal change of both.

Among the multitude of animals which scamper, fly, burrow and swim around us, man is the only one who is not locked into his environment. His imagination, his reason, his emotional subtlety and toughness, make it possible for him not to accept the environment, but to change it. And that series of inventions, by which man from age to age has remade his environment, is a different kind of evolution—not biological, but cultural evolution. I call that brilliant sequence of cultural peaks The Ascent of Man. I use the word ascent with a precise meaning. Man is distinguished from other animals by his imaginative gifts. He makes plans, inventions, new discoveries, by putting different talents together; and his discoveries become more subtle and penetrating, as he learns to combine his talents in more complex and intimate ways. So the great discoveries of different ages and different cultures, in technique, in science, in the arts, express in their progression a richer and more intricate conjunction of human faculties, an ascending trellis of his gifts.

Among the older records, we find chapter after chapter of which we can read the characters, and make out their meaning: and as we approach the period of man’s creation, our book becomes more clear, and nature seems to speak to us in language so like our own, that we easily comprehend it. But just as we begin to enter on the history of physical changes going on before our eyes, and in which we ourselves bear a part, our chronicle seems to fail us—a leaf has been torn out from nature's record, and the succession of events is almost hidden from our eyes.

Among those whom I could never pursuade to rank themselves with idlers, and who speak with indignation of my morning sleeps and nocturnal rambles, one passes the day in catching spiders, that he may count their eyes with a microscope; another exhibits the dust of a marigold separated from the flower with a dexterity worthy of Leuwenhoweck himself. Some turn the wheel of electricity; some suspend rings to a lodestone, and find that what they did yesterday, they can do again to-day.—Some register the changes of the wind, and die fully convinced that the wind is changeable.—There are men yet more profound, who have heard that two colorless liquors may produce a color by union, and that two cold bodies will grow hot of they are mingled: they mingle them, and produce the effect expected, say it is strange, and mingle them again.

Anaximenes ... said that infinite air was the principle, from which the things that are becoming, and that are, and that shall be, and gods and things divine, all come into being, and the rest from its products. The form of air is of this kind: whenever it is most equable it is invisible to sight, but is revealed by the cold and the hot and the damp and by movement. It is always in motion; for things that change do not change unless there be movement. Through becoming denser or finer it has different appearances; for when it is dissolved into what is finer it becomes fire, while winds, again, are air that is becoming condensed, and cloud is produced from air by felting. When it is condensed still more, water is produced; with a further degree of condensation earth is produced, and when condensed as far as possible, stones. The result is that the most influential components of the generation are opposites, hot and cold.

And by the influence of heat, light, and electrical powers, there is a constant series of changes [in animal and vegetal substances]; matter assumes new forms, the destruction of one order of beings tends to the conservation of another, solution and consolidation, decay and renovation, are connected, and whilst the parts of the system, continue in a state of fluctuation and change, the order and harmony of the whole remain unalterable.

And what a science Natural History will be, when we are in our graves, when all the laws of change are thought one of the most important parts of Natural History.

Animals generally seem naturally disposed to … intercourse at about the same period of the year, and that is when winter is changing into summer…. In the human species, the male experiences more under sexual excitement in winter, and the female in summer.

Animals, even plants, lie to each other all the time, and we could restrict the research to them, putting off the real truth about ourselves for the several centuries we need to catch our breath. What is it that enables certain flowers to resemble nubile insects, or opossums to play dead, or female fireflies to change the code of their flashes in order to attract, and then eat, males of a different species?

Anthropology has reached that point of development where the careful investigation of facts shakes our firm belief in the far-reaching theories that have been built up. The complexity of each phenomenon dawns on our minds, and makes us desirous of proceeding more cautiously. Heretofore we have seen the features common to all human thought. Now we begin to see their differences. We recognize that these are no less important than their similarities, and the value of detailed studies becomes apparent. Our aim has not changed, but our method must change. We are still searching for the laws that govern the growth of human culture, of human thought; but we recognize the fact that before we seek for what is common to all culture, we must analyze each culture by careful and exact methods, as the geologist analyzes the succession and order of deposits, as the biologist examines the forms of living matter. We see that the growth of human culture manifests itself in the growth of each special culture. Thus we have come to understand that before we can build up the theory of the growth of all human culture, we must know the growth of cultures that we find here and there among the most primitive tribes of the Arctic, of the deserts of Australia, and of the impenetrable forests of South America; and the progress of the civilization of antiquity and of our own times. We must, so far as we can, reconstruct the actual history of mankind, before we can hope to discover the laws underlying that history.

Apart from the hostile influence of man, the organic and the inorganic world are … bound together by such mutual relations and adaptations as secure, if not the absolute permanence and equilibrium of both … at least a very slow and gradual succession of changes in those conditions. But man is everywhere a disturbing agent. Wherever he plants his foot, the harmonies of nature are turned to discords.

As a result of the phenomenally rapid change and growth of physics, the men and women who did their great work one or two generations ago may be our distant predecessors in terms of the state of the field, but they are our close neighbors in terms of time and tastes. This may be an unprecedented state of affairs among professionals; one can perhaps be forgiven if one characterizes it epigrammatically with a disastrously mixed metaphor; in the sciences, we are now uniquely privileged to sit side-by-side with the giants on whose shoulders we stand.

As a scientist, I am hostile to fundamentalist religion because it actively debauches the scientific enterprise. It teaches us not to change our minds, and not to want to know exciting things that are available to be known. It subverts science and saps the intellect.

As far as the meaning of life in general, or in the abstract, as far as I can see, there is none. If all of life were suddenly to disappear from earth and anywhere else it may exist, or if none had ever formed in the first place, I think the Universe would continue to exist without perceptible change. However, it is always possible for an individual to invest his own life with meaning that he can find significant. He can so order his life that he may find as much beauty and wisdom in it as he can, and spread as much of that to others as possible.

As for the formation of matter, it is never the product of sudden events, but always the outcome of gradual change.

As geologists, we learn that it is not only the present condition of the globe that has been suited to the accommodation of myriads of living creatures, but that many former states also have been equally adapted to the organization and habits of prior races of beings. The disposition of the seas, continents, and islands, and the climates have varied; so it appears that the species have been changed, and yet they have all been so modelled, on types analogous to those of existing plants and animals, as to indicate throughout a perfect harmony of design and unity of purpose. To assume that the evidence of the beginning or end of so vast a scheme lies within the reach of our philosophical inquiries, or even of our speculations, appears to us inconsistent with a just estimate of the relations which subsist between the finite powers of man and the attributes of an Infinite and Eternal Being.

As the human fetus develops, its changing form seems to retrace the whole of human evolution from the time we were cosmic dust to the time we were single-celled organisms in the primordial sea to the time we were four-legged, land-dwelling reptiles and beyond, to our current status as large­brained, bipedal mammals. Thus, humans seem to be the sum total of experience since the beginning of the cosmos.

As the race has advanced from the animal mind to savagery and then to science, the character it has ascribed to the stars, let us say, has undergone the most radical change, but hardly the character of the stars themselves.

As the world of science has grown in size and in power, its deepest problems have changed from the epistemological to the social.

As turning the logs, will make a dull fire burn, so change of studies a dull brain.

At last gleams of light have come, and I am almost convinced (quite contrary to opinion I started with) that species are not (it is like confessing a murder) immutable. Heaven forfend me from Lamarck nonsense of a “tendency to progression”, “adaptations from the slow willing of animals”, &c! But the conclusions I am led to are not widely different from his; though the means of change are wholly so. I think I have found out (here’s presumption!) the simple way by which species become exquisitely adapted to various ends.

Attempts have been made from a study of the changes produced by mutation to obtain the relative order of the bases within various triplets, but my own view is that these are premature until there is more extensive and more reliable data on the composition of the triplets.

Bacteria are highly adaptable. They frequently change both morphologically and functionally. Their virulence is also an essentially fluctuating property, that increases or diminishes according to the conditions to which the pathogenic organism is subjected.

Bankers regard research as most dangerous a thing that makes banking hazardous due to the rapid changes it brings about in industry.

Biological evolution is a system of constant divergence without subsequent joining of branches. Lineages, once distinct, are separate forever. In human history, transmission across lineages is, perhaps, the major source of cultural change. Europeans learned about corn and potatoes from Native Americans and gave them smallpox in return.

Biologists have long attempted by chemical means to induce in higher organisms predictable and specific changes which thereafter could be transmitted in series as hereditary characters. Among microorganisms the most striking example of inheritable and specific alterations in cell structure and function that can be experimentally induced and are reproducible under well defined and adequately controlled conditions is the transformation of specific types of Pneumococcus.

Biology is a science of three dimensions. The first is the study of each species across all levels of biological organization, molecule to cell to organism to population to ecosystem. The second dimension is the diversity of all species in the biosphere. The third dimension is the history of each species in turn, comprising both its genetic evolution and the environmental change that drove the evolution. Biology, by growing in all three dimensions, is progressing toward unification and will continue to do so.

Birds ... are sensitive indicators of the environment, a sort of “ecological litmus paper,” ... The observation and recording of bird populations over time lead inevitably to environmental awareness and can signal impending changes.

Books are the carriers of civilization. Without books, history is silent, literature dumb, science crippled, thought and speculation at a standstill. Without books the development of civilization would have been impossible. They are engines of change, windows on the world, “lighthouses,” (as a poet said), “erected in the sea of time.”

Building goes on briskly at the therapeutic Tower of Babel; what one recommends another condemns; what one gives in large doses another scarce dares to prescribe in small doses; and what one vaunts as a novelty another thinks not worth rescuing from merited oblivion. All is confusion, contradiction, inconceivable chaos. Every country, every place, almost every doctor, have their own pet remedies, without which they imagine their patients can not be cured; and all this changes every year, aye every mouth.

But I canna change the laws of physics, Captain!

But I should be very sorry if an interpretation founded on a most conjectural scientific hypothesis were to get fastened to the text in Genesis... The rate of change of scientific hypothesis is naturally much more rapid than that of Biblical interpretations, so that if an interpretation is founded on such an hypothesis, it may help to keep the hypothesis above ground long after it ought to be buried and forgotten.

But I think that in the repeated and almost entire changes of organic types in the successive formations of the earth—in the absence of mammalia in the older, and their very rare appearance (and then in forms entirely. unknown to us) in the newer secondary groups—in the diffusion of warm-blooded quadrupeds (frequently of unknown genera) through the older tertiary systems—in their great abundance (and frequently of known genera) in the upper portions of the same series—and, lastly, in the recent appearance of man on the surface of the earth (now universally admitted—in one word, from all these facts combined, we have a series of proofs the most emphatic and convincing,—that the existing order of nature is not the last of an uninterrupted succession of mere physical events derived from laws now in daily operation: but on the contrary, that the approach to the present system of things has been gradual, and that there has been a progressive development of organic structure subservient to the purposes of life.

But if any skillful minister of nature shall apply force to matter, and by design torture and vex it, in order to [effect] its annihilation, it, on the contrary being brought under this necessity, changes and transforms itself into a strange variety of shapes and appearances; for nothing but the power of the Creator can annihilate, or truly destroy it.

But science is the great instrument of social change, all the greater because its object is not change but knowledge, and its silent appropriation of this dominant function, amid the din of political and religious strife, is the most vital of all the revolutions which have marked the development of modern civilisation.

But the whole vital process of the earth takes place so gradually and in periods of time which are so immense compared with the length of our life, that these changes are not observed, and before their course can be recorded from beginning to end whole nations perish and are destroyed.

By teaching us how to cultivate each ferment in its purity—in other words, by teaching us how to rear the individual organism apart from all others,—Pasteur has enabled us to avoid all these errors. And where this isolation of a particular organism has been duly effected it grows and multiplies indefinitely, but no change of it into another organism is ever observed. In Pasteur’s researches the Bacterium remained a Bacterium, the Vibrio a Vibrio, the Penicillium a Penicillium, and the Torula a Torula. Sow any of these in a state of purity in an appropriate liquid; you get it, and it alone, in the subsequent crop. In like manner, sow smallpox in the human body, your crop is smallpox. Sow there scarlatina, and your crop is scarlatina. Sow typhoid virus, your crop is typhoid—cholera, your crop is cholera. The disease bears as constant a relation to its contagium as the microscopic organisms just enumerated do to their germs, or indeed as a thistle does to its seed.

Catastrophe Theory is a new mathematical method for describing the evolution of forms in nature. … It is particularly applicable where gradually changing forces produce sudden effects. We often call such effects catastrophes, because our intuition about the underlying continuity of the forces makes the very discontinuity of the effects so unexpected, and this has given rise to the name.

Cellular pathology is not an end if one cannot see any alteration in the cell. Chemistry brings the clarification of living processes nearer than does anatomy. Each anatomical change must have been preceded by a chemical one.

Change is the law of life. And those who look only to the past or the present are certain to miss the future.

Change requires experimentation. But no problem can be solved by the same consciousness that created it. Our job is to dream—and to make those dreams happen.

Change—and extinctions—are inevitable. There are many things totally out of our control. I think we have to come up with a formula that will enable us to preserve biodiversity without necessarily managing it in the sense of trying to freeze it in time. It can't be kept as we first knew it.

Changes That Have Occurred in the Globe: When we have seen with our own eyes a mountain progressing into a plain; that is to say, an immense boulder separating from this mountain and covering the fields; an entire castle broken into pieces over the ground; a river swallowed up which then bursts out from its abyss; clear marks of a vast amount of water having once flooded regions now inhabited, and a hundred vestiges of other transformations, then we are much more willing to believe that great changes altered the face of the earth, than a Parisian lady who knows only that the place where her house was built was once a cultivated field. However, a lady from Naples who has seen the buried ruins of Herculaneum, is much less subject to the bias which leads us to believe that everything has always been as it is today.

Changes, cyclic or otherwise, within the solar system or within our galaxy, would seem to be the easy and incontrovertible solution for everything that I have found remarkable in the stratigraphical record.

Chemistry is one of those branches of human knowledge which has built itself upon methods and instruments by which truth can presumably be determined. It has survived and grown because all its precepts and principles can be re-tested at any time and anywhere. So long as it remained the mysterious alchemy by which a few devotees, by devious and dubious means, presumed to change baser metals into gold, it did not flourish, but when it dealt with the fact that 56 g. of fine iron, when heated with 32 g. of flowers of sulfur, generated extra heat and gave exactly 88 g. of an entirely new substance, then additional steps could be taken by anyone. Scientific research in chemistry, since the birth of the balance and the thermometer, has been a steady growth of test and observation. It has disclosed a finite number of elementary reagents composing an infinite universe, and it is devoted to their inter-reaction for the benefit of mankind.

Chemistry is the study of material transformations. Yet a knowledge of the rate, or time dependence, of chemical change is of critical importance for the successful synthesis of new materials and for the utilization of the energy generated by a reaction. During the past century it has become clear that all macroscopic chemical processes consist of many elementary chemical reactions that are themselves simply a series of encounters between atomic or molecular species. In order to understand the time dependence of chemical reactions, chemical kineticists have traditionally focused on sorting out all of the elementary chemical reactions involved in a macroscopic chemical process and determining their respective rates.

Chemists have made of phlogiston a vague principle which is not at all rigorously defined, and which, in consequence, adapts itself to all explanations in which it is wished it shall enter; sometimes it is free fire, sometimes it is fire combined with the earthy element; sometimes it passes through the pores of vessels, sometimes they are impenetrable to it; it explains both the causticity and non-causticity, transparency and opacity, colours and absence of colours. It is a veritable Proteus which changes its form every instant. It is time to conduct chemistry to a more rigorous mode of reasoning ... to distinguish fact and observation from what is systematic and hypothetical.

Chief Seattle, of the Indians that inhabited the Seattle area, wrote a wonderful paper that has to do with putting oneself in tune with the universe. He said, “Why should I lament the disappearance of my people! All things end, and the white man will find this out also.” And this goes for the universe. One can be at peace with that. This doesn’t mean that one shouldn’t participate in efforts to correct the situation. But underlying the effort to change must be an “at peace.” To win a dog sled race is great. To lose is okay too.

Chymistry. … An art whereby sensible bodies contained in vessels … are so changed, by means of certain instruments, and principally fire, that their several powers and virtues are thereby discovered, with a view to philosophy or medicine.

Civilization has made the peasantry its pack animal. The bourgeoisie in the long run only changed the form of the pack.

Climate change threatens every corner of our country, every sector of our economy and the health and future of every child. We are already seeing its impacts and we know the poorest and most vulnerable people in the United States and around the world will suffer most of all.

Concerning the alchemist, Mamugnano, no one harbors doubts any longer about his daily experiments in changing quicksilver into gold. It was realized that his craft did not go beyond one pound of quicksilver… . Thus the belief is now held that his allegations to produce a number of millions have been a great fraud.

Considered from the standpoint of chemistry, living bodies appear to us as laboratories of chemical processes, for they undergo perpetual changes in their material substrate. They draw materials from the outside world and combine them with the mass of their liquid and solid parts.

Constant, or free, life is the third form of life; it belongs to the most highly organized animals. In it, life is not suspended in any circumstance, it unrolls along a constant course, apparently indifferent to the variations in the cosmic environment, or to the changes in the material conditions that surround the animal. Organs, apparatus, and tissues function in an apparently uniform manner, without their activity undergoing those considerable variations exhibited by animals with an oscillating life. This because in reality the internal environment that envelops the organs, the tissues, and the elements of the tissues does not change; the variations in the atmosphere stop there, so that it is true to say that physical conditions of the environment are constant in the higher animals; it is enveloped in an invariable medium, which acts as an atmosphere of its own in the constantly changing cosmic environment. It is an organism that has placed itself in a hot-house. Thus the perpetual changes in the cosmic environment do not touch it; it is not chained to them, it is free and independent.

Copernicus and Lobatchewsky were both of Slavic origin. Each of them has brought about a revolution in scientific ideas so great that it can only be compared with that wrought by the other. And the reason of the transcendent importance of these two changes is that they are changes in the conception of the Cosmos. … Now the enormous effect of the Copernican system, and of the astronomical discoveries that have followed it, is … the change effected by Copernicus in the idea of the universe. But there was left another to be made. For the laws of space and motion…. So, you see, there is a real parallel between the work of Copernicus and … the work of Lobatchewsky.

Darwinian evolution is the cornerstone of modern biology. But if we accept Darwin’s mechanism for changes in living things, we must postulate another prebiotic form of evolution, which may be described as chemical evolution.

Differences between individuals are the raw materials for evolutionary change and for the evolution of adaptations, yet of course most physiologists treat these differences as noise that is to be filtered out. From the standpoint of physiological ecology, the traditional emphasis of physiologists on central tendencies rather than on variance has some unhappy consequences. Variation is not just noise; it is also the stuff of evolution and a central attribute of living systems. The physiological differences between individuals in the same species or population, and also the patterns of variation in different groups, must not be ignored.

Disease may be defined as “A change produced in living things in consequence of which they are no longer in harmony with their environment.”

Dissection … teaches us that the body of man is made up of certain kinds of material, so differing from each other in optical and other physical characters and so built up together as to give the body certain structural features. Chemical examination further teaches us that these kinds of material are composed of various chemical substances, a large number of which have this characteristic that they possess a considerable amount of potential energy capable of being set free, rendered actual, by oxidation or some other chemical change. Thus the body as a whole may, from a chemical point of view, be considered as a mass of various chemical substances, representing altogether a considerable capital of potential energy.

Each new machine or technique, in a sense, changes all existing machines and techniques, by permitting us to put them together into new combinations. The number of possible combinations rises exponentially as the number of new machines or techniques rises

Ecology and economics may unify toward a more sound use of environmental resources and … can translate into a change in paradigm regarding how humans view nature.

Ecosystems are always in some state of dynamics, sometimes very obviously so, sometimes not. An analogy can be drawn with watching the second and hour hands on a clock. Both hands move, but you can only detect movement in the second hand. Stare at the hour hand all you want: it never seems to move, though it obviously does. Ecosystem change ranges from “watching the second hand” to “watching the hour hand,” depending on what sort of change is occurring.

Education is a mechanism for inducing change and for providing the means of accommodation and adjustment to change. At the same time, as an institution, education is given the responsibility for insuring the preservation and transfer and therefore, the continuity of society’s knowledge, skills, and values.

Engineering is not merely knowing and being knowledgeable, like a walking encyclopedia; engineering is not merely analysis; engineering is not merely the possession of the capacity to get elegant solutions to non-existent engineering problems; engineering is practicing the art of the organizing forces of technological change ... Engineers operate at the interface between science and society.

Euclidean mathematics assumes the completeness and invariability of mathematical forms; these forms it describes with appropriate accuracy and enumerates their inherent and related properties with perfect clearness, order, and completeness, that is, Euclidean mathematics operates on forms after the manner that anatomy operates on the dead body and its members. On the other hand, the mathematics of variable magnitudes—function theory or analysis—considers mathematical forms in their genesis. By writing the equation of the parabola, we express its law of generation, the law according to which the variable point moves. The path, produced before the eyes of the student by a point moving in accordance to this law, is the parabola.
If, then, Euclidean mathematics treats space and number forms after the manner in which anatomy treats the dead body, modern mathematics deals, as it were, with the living body, with growing and changing forms, and thus furnishes an insight, not only into nature as she is and appears, but also into nature as she generates and creates,—reveals her transition steps and in so doing creates a mind for and understanding of the laws of becoming. Thus modern mathematics bears the same relation to Euclidean mathematics that physiology or biology … bears to anatomy.

Even a god cannot change the past.

Even in Europe a change has sensibly taken place in the mind of man. Science has liberated the ideas of those who read and reflect, and the American example has kindled feelings of right in the people. An insurrection has consequently begun of science talents and courage against rank and birth, which have fallen into contempt. It has failed in its first effort, because the mobs of the cities, the instrument used for its accomplishment, debased by ignorance, poverty and vice, could not be restrained to rational action. But the world will soon recover from the panic of this first catastrophe.

Even in the dark times between experimental breakthroughs, there always continues a steady evolution of theoretical ideas, leading almost imperceptibly to changes in previous beliefs.

Even the taking of medicine serves to make time go on with less heaviness. I have a sort of genius for physic and always had great entertainment in observing the changes of the human body and the effects produced by diet, labor, rest, and physical operations.