[M]anufacturing, science and engineering are … incredibly creative. I’d venture to say more so than creative advertising agencies and things that are known as the creative industries.

[Shawn Lawrence Otto describes the damaging] strategy used to undermine science in the interest of those industries where science has pointed out the dangers of their products to individuals and human life in general … [It was] used a generation ago by the tobacco industry… First they manufacture uncertainty by raising doubts about even the most indisputable scientific evidence. Then they launder information by using seemingly independent front organizations to promote their desired message and thereby confuse the public. And finally they recruit unscrupulous scientific spokespeople to misrepresent peer-reviewed scientific findings and cherry-pick facts in an attempt to persuade the media and the public that there is still serious debate among scientists on the issue at hand.

A designer must always think about the unfortunate production engineer who will have to manufacture what you have designed; try to understand his problems.

All important unit operations have much in common, and if the underlying principles upon which the rational design and operation of basic types of engineering equipment depend are understood, their successful adaptation to manufacturing processes becomes a matter of good management rather than of good fortune.

As the Director of the Theoretical Division of Los Alamos, I participated at the most senior level in the World War II Manhattan Project that produced the first atomic weapons.
Now, at age 88, I am one of the few remaining such senior persons alive. Looking back at the half century since that time, I feel the most intense relief that these weapons have not been used since World War II, mixed with the horror that tens of thousands of such weapons have been built since that time—one hundred times more than any of us at Los Alamos could ever have imagined.
Today we are rightly in an era of disarmament and dismantlement of nuclear weapons. But in some countries nuclear weapons development still continues. Whether and when the various Nations of the World can agree to stop this is uncertain. But individual scientists can still influence this process by withholding their skills.
Accordingly, I call on all scientists in all countries to cease and desist from work creating, developing, improving and manufacturing further nuclear weapons - and, for that matter, other weapons of potential mass destruction such as chemical and biological weapons.
[On the occasion of the 50th Anniversary of Hiroshima.]

By his very success in inventing labor-saving devices, modern man has manufactured an abyss of boredom that only the privileged classes in earlier civilizations have ever fathomed.

DNA that used to have some function way back in evolution but currently does not (and might possibly be revived if, say, an ancient parasite reappeared), DNA that controls how genes switch their protein manufacturing on and off, DNA that controls those, and so on. Some may actually be genuine junk. And some (so the joke goes) may encode a message like ‘It was me, I’m God, I existed all along, ha ha.’

Engineers apply the theories and principles of science and mathematics to research and develop economical solutions to practical technical problems. Their work is the link between scientific discoveries and commercial applications. Engineers design products, the machinery to build those products, the factories in which those products are made, and the systems that ensure the quality of the product and efficiency of the workforce and manufacturing process. They design, plan, and supervise the construction of buildings, highways, and transit systems. They develop and implement improved ways to extract, process, and use raw materials, such as petroleum and natural gas. They develop new materials that both improve the performance of products, and make implementing advances in technology possible. They harness the power of the sun, the earth, atoms, and electricity for use in supplying the Nation’s power needs, and create millions of products using power. Their knowledge is applied to improving many things, including the quality of health care, the safety of food products, and the efficient operation of financial systems.

I am a woman who came from the cotton fields of the South. From there I was promoted to the washtub. From there I was promoted to the cook kitchen. And from there I promoted myself into the business of manufacturing hair goods and preparations….I have built my own factory on my own ground.

I am tempted to conclude that a satisfactory hobby must be in large degree useless, inefficient, laborious, or irrelevant. Certainly many of our most satisfying avocations today consist of making something by hand which machines can usually make more quickly and cheaply, and sometimes better. Nevertheless I must in fairness admit that in a different age the mere fashioning of a machine might have been an excellent hobby.

I believe quite simply that the small company of the future will be as much a research organization as it is a manufacturing company.

I find that by confining a workman to one particular limb of the pistol until he has made two thousand, I save at least one quarter of his labor, to what I should provided I finishd them by small quantities; and the work will be as much better as it is quicker made. ... I have some seventeen thousand screws & other parts of pistols now forgd. & many parts nearly finished & the business is going on brisk and lively.
Describing subdivision of labour and standardization of parts.

I have now said enough to show you that it is indispensable for this country to have a scientific education in connexion with manufacturers, if we wish to outstrip the intellectual competition which now, happily for the world, prevails in all departments of industry. As surely as darkness follows the setting of the sun, so surely will England recede as a manufacturing nation, unless her industrial population become much more conversant with science than they are now.

In time, manufacturing will to a great extent follow the sun.
[Speculating that with development of solar power the deserts would become great industrial areas.]

Manufacturing is more than just putting parts together. It’s coming up with ideas, testing principles and perfecting the engineering, as well as final assembly.

Now, we propose in the first place to show, that this law of organic progress is the law of all progress. Whether it be in the development of the Earth, in the development in Life upon its surface, in the development of Society, of Government, of Manufactures, of Commerce, of Language, Literature, Science, Art, this same evolution of the simple into the complex, through a process of continuous differentiation, holds throughout. From the earliest traceable cosmical changes down to the latest results of civilization, we shall find that the transformation of the homogeneous into the heterogeneous is that in which Progress essentially consists.

Prof. Sarabhai had the keen desire that India must be independent in rocket manufacturing, hence he was always full of zeal to do something new.

Science has been arranging, classifying, methodizing, simplifying, everything except itself. It has made possible the tremendous modern development of power of organization which has so multiplied the effective power of human effort as to make the differences from the past seem to be of kind rather than of degree. It has organized itself very imperfectly. Scientific men are only recently realizing that the principles which apply to success on a large scale in transportation and manufacture and general staff work to apply them; that the difference between a mob and an army does not depend upon occupation or purpose but upon human nature; that the effective power of a great number of scientific men may be increased by organization just as the effective power of a great number of laborers may be increased by military discipline.

Suppose the results of a line of study are negative. It might save a lot of otherwise wasted money to know a thing won’t work. But how do you accurately evaluate negative results? ... The power plant in [the recently developed streamline trains] is a Diesel engine of a type which was tried out many [around 25] years ago and found to be a failure. … We didn’t know how to build them. The principle upon which it operated was sound. [Since then much has been] learned in metallurgy [and] the accuracy with which parts can be manufactured
When this type of engine was given another chance it was an immediate success [because now] an accuracy of a quarter of a tenth of a thousandth of an inch [prevents high-pressure oil leaks]. … If we had taken the results of past experience without questioning the reason for the first failure, we would never have had the present light-weight, high-speed Diesel engine which appears to be the spark that will revitalize the railroad business.

That a country, [England], eminently distinguished for its mechanical and manufacturing ingenuity, should be indifferent to the progress of inquiries which form the highest departments of that knowledge on whose more elementary truths its wealth and rank depend, is a fact which is well deserving the attention of those who shall inquire into the causes that influence the progress of nations.

The component parts of the pistols are to correspond so exactly that any limb or part of one Pistol may be fitted to any other Pistol of the Twenty thousand.
Requirement in an 1813 contract with Simeon North to furnish 20,000 pistols.

The evidence from both approaches, statistical and experimental, does not appear sufficiently significant to me to warrant forsaking the pleasure of smoking. As a matter of fact, if the investigations had been pointed toward some material that I thoroughly dislike, such as parsnips, I still would not feel that evidence of the type presented constituted a reasonable excuse for eliminating the things from my diet. I will still continue to smoke, and if the tobacco companies cease manufacturing their product, I will revert to sweet fern and grape leaves.

The Industrial Revolution as a whole was not designed. It took shape gradually as industrialists and engineers figured out how to make things. The result is that we put billions of pounds of toxic materials in the air, water and soil every year and generate gigantic amounts of waste. If our goal is to destroy the world—to produce global warming and toxicity and endocrine disruption—we're doing great.

The mutton in the study gathered over it a thick blanket of Penicillium. On the 13th [December 1875] it had assumed a light brown colour as if by a faint admixture of clay; but the infusion became transparent. The ‘clay’ here was the slime of dead or dormant Bacteria, the cause of their quiescence being the blanket of Penicillium. I found no active life in this tube, while all the others swarmed with Bacteria. In every case where the mould was thick and coherent the Bacteria died, or became dormant, and fell to the bottom of the sediment … The Bacteria which manufacture a green pigment appear to be uniformly victorious in their fight with the Penicillium.

The overwhelming astonishment, the queerest structure we know about so far in the whole universe, the greatest of all cosmological scientific puzzles, confounding all our efforts to comprehend it, is the earth. We are only now beginning to appreciate how strange and splendid it is, how it catches the breath, the loveliest object afloat around the sun, enclosed in its own blue bubble of atmosphere, manufacturing and breathing its own oxygen, fixing its own nitrogen from the air into its own soil, generating its own weather at the surface of its rain forests, constructing its own carapace from living parts: chalk cliffs, coral reefs, old fossils from earlier forms of life now covered by layers of new life meshed together around the globe, Troy upon Troy.

The responsibility for maintaining the composition of the blood in respect to other constituents devolves largely upon the kidneys. It is no exaggeration to say that the composition of the blood is determined not by what the mouth ingests but by what the kidneys keep; they are the master chemists of our internal environment, which, so to speak, they synthesize in reverse. When, among other duties, they excrete the ashes of our body fires, or remove from the blood the infinite variety of foreign substances which are constantly being absorbed from our indiscriminate gastrointestinal tracts, these excretory operations are incidental to the major task of keeping our internal environment in an ideal, balanced state. Our glands, our muscles, our bones, our tendons, even our brains, are called upon to do only one kind of physiological work, while our kidneys are called upon to perform an innumerable variety of operations. Bones can break, muscles can atrophy, glands can loaf, even the brain can go to sleep, without immediately endangering our survival, but when the kidneys fail to manufacture the proper kind of blood neither bone, muscle, gland nor brain can carry on.

There are those who say that the human kidney was created to keep the blood pure, or more precisely, to keep our internal environment in an ideal balanced state. This I must deny. I grant that the human kidney is a marvelous organ, but I cannot grant that it was purposefully designed to excrete urine or to regulate the composition of the blood or to subserve the physiological welfare of Homo sapiens in any sense. Rather I contend that the human kidney manufactures the kind of urine that it does, and it maintains the blood in the composition which that fluid has, because this kidney has a certain functional architecture; and it owes that architecture not to design or foresight or to any plan, but to the fact that the earth is an unstable sphere with a fragile crust, to the geologic revolutions that for six hundred million years have raised and lowered continents and seas, to the predacious enemies, and heat and cold, and storms and droughts; to the unending succession of vicissitudes that have driven the mutant vertebrates from sea into fresh water, into desiccated swamps, out upon the dry land, from one habitation to another, perpetually in search of the free and independent life, perpetually failing, for one reason or another, to find it.

There is romance, the genuine glinting stuff, in typewriters, and not merely in their development from clumsy giants into agile dwarfs, but in the history of their manufacture, which is filled with raids, battles, lonely pioneers, great gambles, hope, fear, despair, triumph. If some of our novels could be written by the typewriters instead of on them, how much better they would be.

To produce any given motion, to spin a certain weight of cotton, or weave any quantity of linen, there is required steam; to produce the steam, fuel; and thus the price of fuel regulates effectively the cost of mechanical power. Abundance and cheapness of fuel are hence main ingredients in industrial success. It is for this reason that in England the active manufacturing districts mark, almost with geological accuracy, the limits of the coal fields.