…comparing the capacity of computers to the capacity of the human brain, I’ve often wondered, where does our success come from? The answer is synthesis, the ability to combine creativity and calculation, art and science, into whole that is much greater than the sum of its parts.

…it ought to be remembered that there is nothing more difficult to take in hand, more perilous to conduct, or more uncertain in its success, than to take the lead in the introduction of a new order of things. Because the innovator has for enemies all those who have done well under the old conditions, and lukewarm defenders in those who may do well under the new.

[A key to success] is being able to talk to camera without a teleprompter. … If you believe something and want to make clear what you are talking about, you ought to be able to articulate it without a teleprompter.

[For imaginary numbers,] their success … has been what the French term a succès de scandale.

[For] men to whom nothing seems great but reason ... nature ... is a cosmos, so admirable, that to penetrate to its ways seems to them the only thing that makes life worth living. These are the men whom we see possessed by a passion to learn ... Those are the natural scientific men; and they are the only men that have any real success in scientific research.

[Fritz Haber's] greatness lies in his scientific ideas and in the depth of his searching. The thought, the plan, and the process are more important to him than the completion. The creative process gives him more pleasure than the yield, the finished piece. Success is immaterial. “Doing it was wonderful.” His work is nearly always uneconomical, with the wastefulness of the rich.

[Jethro Tull] was the first Englishman—perhaps the first writer, ancient and modern—who has attempted, with any tolerable degree of success, to reduce the art of agriculture to certain and uniform principles; and it must be acknowledged that he has done more towards establishing a rational and practical method of husbandry than all the writers who have gone before him.

[Philosopher Lao-tse] is not dogmatic, and he does not go in for big, universal ideas. For instance, I like what he says about failure and success, “Failure is the foundation of success and the means by which it is achieved. Success is the lurking place of failure; but who can tell when the turning point will come?”

[The secret of success is] … Before everything else, get ready.

[Werhner von Braun] is a human leader whose eyes and thoughts have always been turned toward the stars. It would be foolish to assign rocketry success to one person totally. Components must necessarily be the work of many minds; so must successive stages of development. But because Wernher von Braun joins technical ability, passionate optimism, immense experience and uncanny organizing ability in the elusive power to create a team, he is the greatest human element behind today’s rocketry success

Pour réussir dans la science, il faut douter; pour réussir dans la vie, il faut être sûr.
To succeed in science, one must doubt; to succeed in life, one must be sure.

Question: If chimps are so much like us, why are they endangered while humans dominate the globe?
Goodall: Well, in some ways we're not successful at all. We're destroying our home. That's not a bit successful.

99 percent of success is built on failure.

A general State education is a mere contrivance for moulding people to be exactly like one another: and as the mould in which it casts them is that which pleases the predominant power in the government, whether this be a monarch, a priesthood, an aristocracy, or the majority of the existing generation in proportion as it is efficient and successful, it establishes a despotism over the mind, leading by a natural tendency to one over the body.

A great part of its [higher arithmetic] theories derives an additional charm from the peculiarity that important propositions, with the impress of simplicity on them, are often easily discovered by induction, and yet are of so profound a character that we cannot find the demonstrations till after many vain attempts; and even then, when we do succeed, it is often by some tedious and artificial process, while the simple methods may long remain concealed.

A man who has been the indisputable favorite of his mother keeps for life the feeling of a conqueror, that confidence of success that often induces real success.

A New Arithmetic: “I am not much of a mathematician,” said the cigarette, “but I can add nervous troubles to a boy, I can subtract from his physical energy, I can multiply his aches and pains, I can divide his mental powers, I can take interest from his work and discount his chances for success.”

A scientist can be productive in various ways. One is having the ability to plan and carry out experiments, but the other is having the ability to formulate new ideas, which can be about what experiments can be carried out … by making [the] proper calculations. Individual scientists who are successful in their work are successful for different reasons.

A success learns how to make hay from the grass that grows under other people's feet.

A thesis has to be presentable… but don't attach too much importance to it. If you do succeed in the sciences, you will do later on better things and then it will be of little moment. If you don’t succeed in the sciences, it doesn’t matter at all.

Actors start off in commercials playing someone else, but when they’ve really made it they return to commercials playing themselves.

Add to this the pride of achievement; the desire to rank among the successful souls on earth, and we have the factors which have brought some of the ablest of human beings into the limelight that revealed them to an admiring world, as leaders and examples.

Again and again the imaginary plan on which one attempts to build up order breaks down and then we must try another. This imaginative vision and faith in the ultimate success are indispensable. The pure rationalist has no place here.

All human affairs follow nature's great analogue, the growth of vegetation. There are three periods of growth in every plant. The first, and slowest, is the invisible growth by the root; the second and much accelerated is the visible growth by the stem; but when root and stem have gathered their forces, there comes the third period, in which the plant quickly flashes into blossom and rushes into fruit.
The beginnings of moral enterprises in this world are never to be measured by any apparent growth. ... At length comes the sudden ripeness and the full success, and he who is called in at the final moment deems this success his own. He is but the reaper and not the labourer. Other men sowed and tilled and he but enters into their labours.

All life is linked together in such a way that no part of the chain is unimportant. Frequently, upon the action of some of these minute beings depends the material success or failure of a great commonwealth.

All scientific theories are provisional and may be changed, but ... on the whole, they are accepted from Washington to Moscow because of their practical success. Where religion has opposed the findings of science, it has almost always had to retreat.

Almost every major systematic error which has deluded men for thousands of years relied on practical experience. Horoscopes, incantations, oracles, magic, witchcraft, the cures of witch doctors and of medical practitioners before the advent of modern medicine, were all firmly established through the centuries in the eyes of the public by their supposed practical successes. The scientific method was devised precisely for the purpose of elucidating the nature of things under more carefully controlled conditions and by more rigorous criteria than are present in the situations created by practical problems.

An indispensable hypothesis, even though still far from being a guarantee of success, is however the pursuit of a specific aim, whose lighted beacon, even by initial failures, is not betrayed.

An inventor fails 999 times, and if he succeeds once, he’s in. He treats his failures simply as practice shots.

An inventor is an opportunist, one who takes occasion by the hand; who, having seen where some want exists, successfully applies the right means to attain the desired end. The means may be largely, or even wholly, something already known, or there may be a certain originality or discovery in the means employed. But in every case the inventor uses the work of others. If I may use a metaphor, I should liken him to the man who essays the conquest of some virgin alp. At the outset he uses the beaten track, and, as he progresses in the ascent, he uses the steps made by those who have preceded him, whenever they lead in the right direction; and it is only after the last footprints have died out that he takes ice-axe in hand and cuts the remaining steps, few or many, that lift him to the crowning height which is his goal.

An inventor is simply a fellow who doesn’t take his education too seriously. You see, from the time a person is six years old until he graduates form college he has to take three or four examinations a year. If he flunks once, he is out. But an inventor is almost always failing. He tries and fails maybe a thousand times. It he succeeds once then he’s in. These two things are diametrically opposite. We often say that the biggest job we have is to teach a newly hired employee how to fail intelligently. We have to train him to experiment over and over and to keep on trying and failing until he learns what will work.

An old medical friend gave me some excellent practical advice. He said: “You will have for some time to go much oftener down steps than up steps. Never mind! win the good opinions of washerwomen and such like, and in time you will hear of their recommendations of you to the wealthier families by whom they are employed.” I did so, and found it succeed as predicted.
[On beginning a medical practice.]

And yet in a funny way our lack of success led to our breakthrough; because, since we could not get a cell line off the shelf doing what we wanted, we were forced to construct it. And the original experiment ... developed into a method for the production of hybridomas ... [which] was of more importance than our original purpose.

Another characteristic of mathematical thought is that it can have no success where it cannot generalize.

Any demanding high technology tends to develop influential and dedicated constituencies of those who link its commercial success with both the public welfare and their own. Such sincerely held beliefs, peer pressures, and the harsh demands that the work i

Any man who says he doesn’t like applause and recognition is either a fool or a liar. You learn from mistakes, but success gives you the courage to go on and do even more.

Any policy is a success by sufficiently low standards and a failure by sufficiently high standards.

Applied research generates improvements, not breakthroughs. Great scientific advances spring from pure research. Even scientists renowned for their “useful” applied discoveries often achieved success only when they abandoned their ostensible applied-science goal and allowed their minds to soar—as when Alexander Fleming, “just playing about,” refrained from throwing away green molds that had ruined his experiment, studied them, and discovered penicillin. Or when C. A. Clarke, a physician affiliated with the University of Liverpool, became intrigued in the 1950s by genetically created color patterns that emerged when he cross-bred butterflies as a hobby. His fascination led him—“by the pleasant route of pursuing idle curiosity”—to the successful idea for preventing the sometimes fatal anemia that threatened babies born of a positive-Rhesus-factor father and a negative-Rhesus-factor mother.

As a career, the business of an orthodox preacher is about as successful as that of a celluloid dog chasing an asbestos cat through hell.

As a general rule, the most successful man in life is the man who has the best information.

As a progressive discipline [biochemistry] belongs to the present century. From the experimental physiologists of the last century it obtained a charter, and, from a few pioneers of its own, a promise of success; but for the furtherance of its essential aim that century left it but a small inheritance of facts and methods. By its essential or ultimate aim I myself mean an adequate and acceptable description of molecular dynamics in living cells and tissues.

As an eminent pioneer in the realm of high frequency currents … I congratulate you [Nikola Tesla] on the great successes of your life’s work.

As immoral and unethical as this may be [to clone a human], there is a real chance that could have had some success. This is a pure numbers game. If they have devoted enough resources and they had access to enough eggs, there is a distinct possibility. But, again, without any scientific data, one has to be extremely skeptical.
Commenting on the announcement of the purported birth of the first cloned human.

At the present time it is of course quite customary for physicists to trespass on chemical ground, for mathematicians to do excellent work in physics, and for physicists to develop new mathematical procedures. … Trespassing is one of the most successful techniques in science.

AZT stood up and said, 'Stop your pessimism. Stop your sense of futility. Go back to the lab. Go back to development. Go back to clinical trials. Things will work.'
[On the impact of AZT emerging as the long-sought first significant AIDS drug.]

Bacteria represent the world’s greatest success story. They are today and have always been the modal organisms on earth; they cannot be nuked to oblivion and will outlive us all. This time is their time, not the ‘age of mammals’ as our textbooks chauvinistically proclaim. But their price for such success is permanent relegation to a microworld, and they cannot know the joy and pain of consciousness. We live in a universe of trade-offs; complexity and persistence do not work well as partners.

Be of good cheer. Do not think of today’s failures, but of the success that may come tomorrow. You have set yourself a difficult task, but you will succeed if you persevere; and you will find a joy in overcoming obstacles.

Before anything else, preparation is the key to success.

Believe and act as if it were impossible to fail.

Both died, ignored by most; they neither sought nor found public favour, for high roads never lead there. Laurent and Gerhardt never left such roads, were never tempted to peruse those easy successes which, for strongly marked characters, offer neither allure nor gain. Their passion was for the search for truth; and, preferring their independence to their advancement, their convictions to their interests, they placed their love for science above that of their worldly goods; indeed above that for life itself, for death was the reward for their pains. Rare example of abnegation, sublime poverty that deserves the name nobility, glorious death that France must not forget!

Business, to be successful, must be based on science, for demand and supply are matters of mathematics, not guesswork.

By his very success in inventing labor-saving devices, modern man has manufactured an abyss of boredom that only the privileged classes in earlier civilizations have ever fathomed.

Character cannot be developed in ease and quiet. Only through experience of trial and suffering can the soul be strengthened, ambition inspired, and success achieved.

Christ, it’s going to work!

Colleague reader, please read this to your uncertain teenager con brio! Tell him or her that (1) experiments often fail, and (2) they don't always fail.
[Co-author with Dick Teresi]

Despite the dazzling successes of modern technology and the unprecedented power of modern military systems, they suffer from a common and catastrophic fault. While providing us with a bountiful supply of food, with great industrial plants, with high-speed transportation, and with military weapons of unprecedented power, they threaten our very survival.

Despite the high long-term probability of extinction, every organism alive today, including every person reading this paper, is a link in an unbroken chain of parent-offspring relationships that extends back unbroken to the beginning of life on earth. Every living organism is a part of an enormously long success story—each of its direct ancestors has been sufficiently well adapted to its physical and biological environments to allow it to mature and reproduce successfully. Viewed thus, adaptation is not a trivial facet of natural history, but a biological attribute so central as to be inseparable from life itself.

Edison was by far the most successful and, probably, the last exponent of the purely empirical method of investigation. Everything he achieved was the result of persistent trials and experiments often performed at random but always attesting extraordinary vigor and resource. Starting from a few known elements, he would make their combinations and permutations, tabulate them and run through the whole list, completing test after test with incredible rapidity until he obtained a clue. His mind was dominated by one idea, to leave no stone unturned, to exhaust every possibility.

Elegance is not a dispensable luxury but a quality that decides between success and failure.

ENGINEER, in the military art, an able expert man, who, by a perfect knowledge in mathematics, delineates upon paper, or marks upon the ground, all sorts of forts, and other works proper for offence and defence. He should understand the art of fortification, so as to be able, not only to discover the defects of a place, but to find a remedy proper for them; as also how to make an attack upon, as well as to defend, the place. Engineers are extremely necessary for these purposes: wherefore it is requisite that, besides being ingenious, they should be brave in proportion. When at a siege the engineers have narrowly surveyed the place, they are to make their report to the general, by acquainting him which part they judge the weakest, and where approaches may be made with most success. Their business is also to delineate the lines of circumvallation and contravallation, taking all the advantages of the ground; to mark out the trenches, places of arms, batteries, and lodgments, taking care that none of their works be flanked or discovered from the place. After making a faithful report to the general of what is a-doing, the engineers are to demand a sufficient number of workmen and utensils, and whatever else is necessary.

Environment counts for a great deal. A man’s particular idea may have no chance for growth or encouragement in his community. Real success is denied that man, until he finds a proper environment.

Envy is an eyesore engendered by looking at another’s success thru the spectacles of our own inferiority.

Euler’s Tentamen novae theorae musicae had no great success, as it contained too much geometry for musicians, and too much music for geometers.

Ever since celestial mechanics in the skillful hands of Leverrier and Adams led to the world-amazed discovery of Neptune, a belief has existed begotten of that success that still other planets lay beyond, only waiting to be found.

Every discoverer of a new truth, or inventor of the method which evolves it, makes a dozen, perhaps fifty, useless combinations, experiments, or trials for one successful one. In the realm of electricity or of mechanics there is no objection to this. But when such rejected failures involve a torture of animals, sometimes fearful in its character, there is a distinct objection to it.

Every failure is a step to success.

Every great improvement has come after repeated failures. Virtually nothing comes out right the first time. Failures, repeated failures, are finger posts on the road to achievement. One fails forward toward success.

Every new theory as it arises believes in the flush of youth that it has the long sought goal; it sees no limits to its applicability, and believes that at last it is the fortunate theory to achieve the 'right' answer. This was true of electron theory—perhaps some readers will remember a book called The Electrical Theory of the Universe by de Tunzelman. It is true of general relativity theory with its belief that we can formulate a mathematical scheme that will extrapolate to all past and future time and the unfathomed depths of space. It has been true of wave mechanics, with its first enthusiastic claim a brief ten years ago that no problem had successfully resisted its attack provided the attack was properly made, and now the disillusionment of age when confronted by the problems of the proton and the neutron. When will we learn that logic, mathematics, physical theory, are all only inventions for formulating in compact and manageable form what we already know, like all inventions do not achieve complete success in accomplishing what they were designed to do, much less complete success in fields beyond the scope of the original design, and that our only justification for hoping to penetrate at all into the unknown with these inventions is our past experience that sometimes we have been fortunate enough to be able to push on a short distance by acquired momentum.

Every technological success is hailed as a great scientific achievement; every technological disaster is deemed an engineering failure.

Evolution is an obstacle course not a freeway; the correct analogue for long-term success is a distant punt receiver evading legions of would-be tacklers in an oddly zigzagged path toward a goal, not a horse thundering down the flat.

Facts are a heap of bricks and timber. It is only a successful theory that can convert the heap into a stately mansion

Failure is central to engineering. Every single calculation that an engineer makes is a failure calculation. Successful engineering is all about understanding how things break or fail.

Failure is so much more interesting because you learn from it. That’s what we should be teaching children at school, that being successful the first time, there’s nothing in it. There’s no interest, you learn nothing actually.

Failure is success if we learn from it.

Failure is, in a sense, the highway to success, inasmuch as every discovery of what is false leads us to seek earnestly after what is true.

Famine seems to be the last, the most dreadful resource of nature. The power of population is so superior to the power in the earth to produce subsistence for man, that premature death must in some shape or other visit the human race. The vices of mankind are active and able ministers of depopulation. They are the precursors in the great army of destruction; and often finish the dreadful work themselves. But should they fail in this war of extermination, sickly seasons, epidemics, pestilence, and plague, advance in terrific array, and sweep off their thousands and ten thousands. Should success be still incomplete, gigantic inevitable famine stalks in the rear, and with one mighty blow, levels the population with the food of the world.

Finally, two days ago, I succeeded - not on account of my hard efforts, but by the grace of the Lord. Like a sudden flash of lightning, the riddle was solved. I am unable to say what was the conducting thread that connected what I previously knew with what made my success possible.

First get a clear notion of what you desire to accomplish and then in all probability you will succeed in doing it.

First, as concerns the success of teaching mathematics. No instruction in the high schools is as difficult as that of mathematics, since the large majority of students are at first decidedly disinclined to be harnessed into the rigid framework of logical conclusions. The interest of young people is won much more easily, if sense-objects are made the starting point and the transition to abstract formulation is brought about gradually. For this reason it is psychologically quite correct to follow this course.
Not less to be recommended is this course if we inquire into the essential purpose of mathematical instruction. Formerly it was too exclusively held that this purpose is to sharpen the understanding. Surely another important end is to implant in the student the conviction that correct thinking based on true premises secures mastery over the outer world. To accomplish this the outer world must receive its share of attention from the very beginning.
Doubtless this is true but there is a danger which needs pointing out. It is as in the case of language teaching where the modern tendency is to secure in addition to grammar also an understanding of the authors. The danger lies in grammar being completely set aside leaving the subject without its indispensable solid basis. Just so in Teaching of Mathematics it is possible to accumulate interesting applications to such an extent as to stunt the essential logical development. This should in no wise be permitted, for thus the kernel of the whole matter is lost. Therefore: We do want throughout a quickening of mathematical instruction by the introduction of applications, but we do not want that the pendulum, which in former decades may have inclined too much toward the abstract side, should now swing to the other extreme; we would rather pursue the proper middle course.

Flaming enthusiasm, backed by horse sense and persistence, is the quality that most frequently makes for success.

Haldane could have made a success of any one of half a dozen careers—as mathematician, classical scholar, philosopher, scientist, journalist or imaginative writer. On his life’s showing he could not have been a politician, administrator (heavens, no!), jurist or, I think, a critic of any kind. In the outcome he became one of the three or four most influential biologists of his generation.

Happily, facts have become so multiplied, that Geology is daily emerging from that state when an hypothesis, provided it were brilliant and ingenious, was sure of advocates and temporary success, when when it sinned against the laws of physics and the facts themselves.

Hope is the companion of power and the mother of success, for those of us who hope strongest have within us the gift of miracles.

How can he [Thomas Edison] call it a wonderful success when everyone acquainted with the subject will recognize it as a conspicuous failure?

How do we convince people that in programming simplicity and clarity–in short: what mathematicians call ‘elegance’–are not a dispensable luxury, but a crucial matter that decides between success and failure?

How few people will realize how much detail had to be gone into before Bakelite was a commercial success.

How was your flight? Well, aeronautically it was a great success. Socially, it left quite a bit to be desired.

However far the mathematician’s calculating senses seem to be separated from the audacious flight of the artist’s imagination, these manifestations refer to mere instantaneous images, which have been arbitrarily torn from the operation of both. In designing new theories, the mathematician needs an equally bold and inspired imagination as creative as the artist, and in carrying out the details of a work the artist must unemotionally reckon all the resources necessary for the success of the parts. Common to both is the fabrication, the creation of the structure from the intellect.

I always rejoice to hear of your being still employed in experimental researches into nature, and of the success you meet with. The rapid progress true science now makes, occasions my regretting sometimes that I was born so soon: it is impossible to imagine the height to which may be carried, in a thousand years, the power of man over matter; we may perhaps learn to deprive large masses of their gravity, and give them absolute levity for the sake of easy transport. Agriculture may diminish its labour and double its produce; all diseases may by sure means be prevented or cured (not excepting even that of old age), and our lives lengthened at pleasure even beyond the antediluvian standard. Oh! that moral science were in as fair a way of improvement; that men would cease to be wolves to one another; and that human beings would at length learn what they now improperly call humanity!

I am more fond of achieving than striving. My theories must prove to be facts or be discarded as worthless. My efforts must soon be crowned with success, or discontinued.

I am never content until I have constructed a mechanical model of the subject I am studying. If I succeed in making one, I understand. Otherwise, I do not. [Attributed; source unverified.]

I am now convinced that we have recently become possessed of experimental evidence of the discrete or grained nature of matter, which the atomic hypothesis sought in vain for hundreds and thousands of years. The isolation and counting of gaseous ions, on the one hand, which have crowned with success the long and brilliant researches of J.J. Thomson, and, on the other, agreement of the Brownian movement with the requirements of the kinetic hypothesis, established by many investigators and most conclusively by J. Perrin, justify the most cautious scientist in now speaking of the experimental proof of the atomic nature of matter, The atomic hypothesis is thus raised to the position of a scientifically well-founded theory, and can claim a place in a text-book intended for use as an introduction to the present state of our knowledge of General Chemistry.

I am sure that one secret of a successful teacher is that he has formulated quite clearly in his mind what the pupil has got to know in precise fashion. He will then cease from half-hearted attempts to worry his pupils with memorising a lot of irrelevant stuff of inferior importance.

I am trying to get the hang of this new fangled writing machine, but I am not making a shining success of it. However, this is the first attempt I have ever made & yet I perceive I shall soon & easily acquire a fine facility in its use. … The machine has several virtues. I believe it will print faster than I can write. One may lean back in his chair & work it. It piles an awful stack of words on one page. It don't muss things or scatter ink blots around. Of course it saves paper.

I am very sorry, Pyrophilus, that to the many (elsewhere enumerated) difficulties which you may meet with, and must therefore surmount, in the serious and effectual prosecution of experimental philosophy I must add one discouragement more, which will perhaps is much surprise as dishearten you; and it is, that besides that you will find (as we elsewhere mention) many of the experiments published by authors, or related to you by the persons you converse with, false and unsuccessful (besides this, I say), you will meet with several observations and experiments which, though communicated for true by candid authors or undistrusted eye-witnesses, or perhaps recommended by your own experience, may, upon further trial, disappoint your expectation, either not at all succeeding constantly, or at least varying much from what you expected.

I attribute my success to this:— I never gave or took an excuse.

I called it ignose, not knowing which carbohydrate it was. This name was turned down by my editor. 'God-nose' was not more successful, so in the end 'hexuronic acid' was agreed upon. To-day the substance is called 'ascorbic acid' and I will use this name.

I confess that Fermat’s Theorem as an isolated proposition has very little interest for me, for a multitude of such theorems can easily be set up, which one could neither prove nor disprove. But I have been stimulated by it to bring our again several old ideas for a great extension of the theory of numbers. Of course, this theory belongs to the things where one cannot predict to what extent one will succeed in reaching obscurely hovering distant goals. A happy star must also rule, and my situation and so manifold distracting affairs of course do not permit me to pursue such meditations as in the happy years 1796-1798 when I created the principal topics of my Disquisitiones arithmeticae. But I am convinced that if good fortune should do more than I expect, and make me successful in some advances in that theory, even the Fermat theorem will appear in it only as one of the least interesting corollaries.
In reply to Olbers' attempt in 1816 to entice him to work on Fermat's Theorem. The hope Gauss expressed for his success was never realised.

I do believe that a scientist is a freelance personality. We’re driven by an impulse which is one of curiosity, which is one of the basic instincts that a man has. So we are … driven … not by success, but by a sort of passion, namely the desire of understanding better, to possess, if you like, a bigger part of the truth. I do believe that science, for me, is very close to art.

I do not think it is possible really to understand the successes of science without understanding how hard it is—how easy it is to be led astray, how difficult it is to know at any time what is the next thing to be done.

I do not think there is any thrill that can go through the human heart like that felt by the inventor as he sees some creation of the brain unfolding to success... Such emotions make a man forget food, sleep, friends, love, everything.

I have had three personal ideals. One, to do the day’s work well and not to bother about tomorrow.… The second ideal has been to act the Golden Rule, as far as in me lay, towards my professional brethren and towards the patients committed to my care. And the third has been to cultivate such a measure of equanimity as would enable me to bear success with humility, the affection of my friends without pride, and to be ready when the day of sorrow and grief came to meet it with the courage befitting a man.

I have never looked upon ease and happiness as ends in themselves–this critical basis I call the ideal of a pigsty. The ideals that have lighted my way, and time after time have given me new courage to face life cheerfully, have been Kindness, Beauty, and Truth. Without the sense of kinship with men of like mind, without the occupation with the objective world, the eternally unattainable in the field of art and scientific endeavors, life would have seemed empty to me. The trite objects of human efforts–possessions, outward success, luxury–have always seemed to me contemptible.

I know two people who have found it [the secret of success]. … Getting ready. Getting prepared. There were Edison and Lindbergh,—they both got ready before they started. I had to find that out too. I had to stop for ten years after I had started; I had to stop for ten years and get ready. I made my first car in 1893, but it was 1903 before I had it ready to sell. It is these simple things that young men ought to know, and they are hardest to grasp. Before everything else, get ready.

I learned this, at least, by my experiment: that if one advances confidently in the direction of his dreams, and endeavors to live the life which he has imagined, he will meet with a success unexpected in common hours.

I must admit that I personally measure success in terms of the contributions an individual makes to her or his fellow human beings.

I never found it easy. People say I was lucky twice but I resent that. We stuck with [cimetidine] for four years with no progress until we eventually succeeded. It was not luck, it was bloody hard work.
[Rejecting that drug discovery was easier in the past.]

I ought to say that one of our first joint researches, so far as publication was concerned, had the peculiar effect of freeing me forever from the wiles of college football, and if that is a defect, make the most of it! Dr. Noyes and I conceived an idea on sodium aluminate solutions on the morning of the day of a Princeton-Harvard game (as I recall it) that we had planned to attend. It looked as though a few days' work on freezing-point determinations and electrical conductivities would answer the question. We could not wait, so we gave up the game and stayed in the laboratory. Our experiments were successful. I think that this was the last game I have ever cared about seeing. I mention this as a warning, because this immunity might attack anyone. I find that I still complainingly wonder at the present position of football in American education.

I then began to study arithmetical questions without any great apparent result, and without suspecting that they could have the least connexion with my previous researches. Disgusted at my want of success, I went away to spend a few days at the seaside, and thought of entirely different things. One day, as I was walking on the cliff, the idea came to me, again with the same characteristics of conciseness, suddenness, and immediate certainty, that arithmetical transformations of indefinite ternary quadratic forms are identical with those of non-Euclidian geometry.

I think I’ve had more failures than successes, but I don’t see the failures as mistakes because I always learned something from those experiences. I see them as having not achieved the initial goal, nothing more than that.

I think science has enjoyed an extraordinary success because it has such a limited and narrow realm in which to focus its efforts. Namely, the physical universe.

I tried and failed. I tried again and again and succeeded.
[Epitaph from Gail Borden's gravestone.]

I want my books sold on airport bookstalls.

I was always afraid of things that worked the first time. Long experience proved that there were great drawbacks found generally before they could be got commercial; but here was something there was no doubt of.
[Recalling astonishment when his tin-foil cylinder phonograph first played back his voice recording of “Mary had a little lamb.”]

I’m a lapel-clutcher by nature. I’m always running up to people and shaking them and saying, “Have you heard?” I believe man has a compulsion to communicate and his evolutionary success is due to it. And I’ve got it. I relive the pleasure I found in it when I tell someone about it.

If A is a success in life, I should say the formula is A = X + Y + Z, X being work and Y being play. … … [Z] is keeping your mouth shut.

If a man is not bound down, he is sure to succeed.

If a solution fails to appear … and yet we feel success is just around the corner, try resting for a while. … Like the early morning frost, this intellectual refreshment withers the parasitic and nasty vegetation that smothers the good seed. Bursting forth at last is the flower of truth.

If at first you don’t succeed, try, try, try again.

If my efforts have led to greater success than usual, this is due, I believe, to the fact that during my wanderings in the field of medicine, I have strayed onto paths where the gold was still lying by the wayside. It takes a little luck to be able to distinguish gold from dross, but that is all.

If there be one man, more than another, who deserves to succeed in flying through the air, that man is Mr. Laurence Hargrave, of Sydney, New South Wales.

If we consider what science already has enabled men to know—the immensity of space, the fantastic philosophy of the stars, the infinite smallness of the composition of atoms, the macrocosm whereby we succeed only in creating outlines and translating a measure into numbers without our minds being able to form any concrete idea of it—we remain astounded by the enormous machinery of the universe.

If we do not learn to eliminate waste and to be more productive and more efficient in the ways we use energy, then we will fall short of this goal [for the Nation to derive 20 percent of all the energy we use from the Sun, by 2000]. But if we use our technological imagination, if we can work together to harness the light of the Sun, the power of the wind, and the strength of rushing streams, then we will succeed.

If you advertise to tell lies, it will ruin you, but if you advertise to tell the public the truth, and particularly to give information, it will bring you success. I learned early that to tell a man how best to use tires, and to make him want them, was far better than trying to tell him that your tire is the best in the world. If you believe that yours is, let your customer find it out.

If you are young, then I say: Learn something about statistics as soon as you can. Don’t dismiss it through ignorance or because it calls for thought. … If you are older and already crowned with the laurels of success, see to it that those under your wing who look to you for advice are encouraged to look into this subject. In this way you will show that your arteries are not yet hardened, and you will be able to reap the benefits without doing overmuch work yourself. Whoever you are, if your work calls for the interpretation of data, you may be able to do without statistics, but you won’t do as well.

If you care to be a master or to make a true success of your profession, the smallest detail of your work must be done with thoroughness. To be thorough in medicine means that in the ever alluring present, we do not forget the past.

If you hope to make a success of life you must be willing to do whatever comes your way to the best of your ability.

In [David] Douglas's success in life ... his great activity, undaunted courage, singular abstemiousness, and energetic zeal, at once pointed him out as an individual eminently calculated to do himself credit as a scientific traveler.

In 1945, therefore, I proved a sentimental fool; and Mr. Truman could safely have classified me among the whimpering idiots he did not wish admitted to the presidential office. For I felt that no man has the right to decree so much suffering, and that science, in providing and sharpening the knife and in upholding the ram, had incurred a guilt of which it will never get rid. It was at that time that the nexus between science and murder became clear to me. For several years after the somber event, between 1947 and 1952, I tried desperately to find a position in what then appeared to me as a bucolic Switzerland,—but I had no success.

In fact, Gentlemen, no geometry without arithmetic, no mechanics without geometry... you cannot count upon success, if your mind is not sufficiently exercised on the forms and demonstrations of geometry, on the theories and calculations of arithmetic ... In a word, the theory of proportions is for industrial teaching, what algebra is for the most elevated mathematical teaching.

In general, art has preceded science. Men have executed great, and curious, and beautiful works before they had a scientific insight into the principles on which the success of their labours was founded. There were good artificers in brass and iron before the principles of the chemistry of metals were known; there was wine among men before there was a philosophy of vinous fermentation; there were mighty masses raised into the air, cyclopean walls and cromlechs, obelisks and pyramids—probably gigantic Doric pillars and entablatures—before there was a theory of the mechanical powers. … Art was the mother of Science.

In honoring the Wright Brothers, it is customary and proper to recognize their contribution to scientific progress. But I believe it is equally important to emphasize the qualities in their pioneering life and the character in man that such a life produced. The Wright Brothers balanced sucess with modesty, science with simplicity. At Kitty Hawk their intellects and senses worked in mutual support. They represented man in balance, and from that balance came wings to lift a world.

In my view, the proper attitude of a public-service broadcaster is that it should attempt to cover as broad as possible a spectrum of human interest and should measure success by the width of those views. There shouldn’t be all that large a number of gaps in the spectrum; and a major element in the spectrum is scientific understanding. The fact that it doesn’t necessarily get as big an audience as cookery is of no consequence.

In no subject is there a rule, compliance with which will lead to new knowledge or better understanding. Skilful observations, ingenious ideas, cunning tricks, daring suggestions, laborious calculations, all these may be required to advance a subject. Occasionally the conventional approach in a subject has to be studiously followed; on other occasions it has to be ruthlessly disregarded. Which of these methods, or in what order they should be employed is generally unpredictable. Analogies drawn from the history of science are frequently claimed to be a guide; but, as with forecasting the next game of roulette, the existence of the best analogy to the present is no guide whatever to the future. The most valuable lesson to be learnt from the history of scientific progress is how misleading and strangling such analogies have been, and how success has come to those who ignored them.

In one department of his [Joseph Black’s] lecture he exceeded any I have ever known, the neatness and unvarying success with which all the manipulations of his experiments were performed. His correct eye and steady hand contributed to the one; his admirable precautions, foreseeing and providing for every emergency, secured the other. I have seen him pour boiling water or boiling acid from a vessel that had no spout into a tube, holding it at such a distance as made the stream’s diameter small, and so vertical that not a drop was spilt. While he poured he would mention this adaptation of the height to the diameter as a necessary condition of success. I have seen him mix two substances in a receiver into which a gas, as chlorine, had been introduced, the effect of the combustion being perhaps to produce a compound inflammable in its nascent state, and the mixture being effected by drawing some string or wire working through the receiver's sides in an air-tight socket. The long table on which the different processes had been carried on was as clean at the end of the lecture as it had been before the apparatus was planted upon it. Not a drop of liquid, not a grain of dust remained.

In that pure enjoyment experienced on approaching to the ideal, in that eagerness to draw aside the veil from the hidden truth, and even in that discord which exists between the various workers, we ought to see the surest pledges of further scientific success. Science thus advances, discovering new truths, and at the same time obtaining practical results.

In the conception of a machine or the product of a machine there is a point where one may leave off for parsimonious reasons, without having reached aesthetic perfection; at this point perhaps every mechanical factor is accounted for, and the sense of incompleteness is due to the failure to recognize the claims of the human agent. Aesthetics carries with it the implications of alternatives between a number of mechanical solutions of equal validity; and unless this awareness is present at every stage of the process … it is not likely to come out with any success in the final stage of design.

In the course of the last century science has become so dizzy with its successes, that it has forgotten to ask the pertinent questions—or refused to ask them under the pretext that they are meaningless, and in any case not the scientists concern.

In the infancy of physical science, it was hoped that some discovery might be made that would enable us to emancipate ourselves from the bondage of gravity, and, at least, pay a visit to our neighbour the moon. The poor attempts of the aeronaut have shewn the hopelessness of the enterprise. The success of his achievement depends on the buoyant power of the atmosphere, but the atmosphere extends only a few miles above the earth, and its action cannot reach beyond its own limits. The only machine, independent of the atmosphere, we can conceive of, would be one on the principle of the rocket. The rocket rises in the air, not from the resistance offered by the atmosphere to its fiery stream, but from the internal reaction. The velocity would, indeed, be greater in a vacuum than in the atmosphere, and could we dispense with the comfort of breathing air, we might, with such a machine, transcend the boundaries of our globe, and visit other orbs.

In the next twenty centuries … humanity may begin to understand its most baffling mystery—where are we going? The earth is, in fact, traveling many thousands of miles per hour in the direction of the constellation Hercules—to some unknown destination in the cosmos. Man must understand his universe in order to understand his destiny. Mystery, however, is a very necessary ingredient in our lives. Mystery creates wonder and wonder is the basis for man’s desire to understand. Who knows what mysteries will be solved in our lifetime, and what new riddles will become the challenge of the new generation? Science has not mastered prophesy. We predict too much for the next year yet far too little for the next ten. Responding to challenges is one of democracy’s great strengths. Our successes in space can be used in the next decade in the solution of many of our planet’s problems.

In the patient who succumbed, the cause of death was evidently something which was not found in the patient who recovered; this something we must determine, and then we can act on the phenomena or recognize and foresee them accurately. But not by statistics shall we succeed in this; never have statistics taught anything, and never can they teach anything about the nature of the phenomenon.

In these strenuous times, we are likely to become morbid and look constantly on the dark side of life, and spend entirely too much time considering and brooding over what we can't do, rather than what we can do, and instead of growing morose and despondent over opportunities either real or imaginary that are shut from us, let us rejoice at the many unexplored fields in which there is unlimited fame and fortune to the successful explorer and upon which there is no color line; simply the survival of the fittest.