… the icy layers of the upper atmosphere contain conundrums enough to be worthy of humanity's greatest efforts.

…cabinet naturalists [who] of nature saw almost nothing but what [that] is conserved in museums.

…we are all inclined to ... direct our inquiry not by the matter itself, but by the views of our opponents; and, even when interrogating oneself, one pushes the inquiry only to the point at which one can no longer offer any opposition. Hence a good inquirer will be one who is ready in bringing forward the objections proper to the genus, and that he will be when he has gained an understanding of the differences.

“Endow scientific research and we shall know the truth, when and where it is possible to ascertain it;” but the counterblast is at hand: “To endow research is merely to encourage the research for endowment; the true man of science will not be held back by poverty, and if science is of use to us, it will pay for itself.” Such are but a few samples of the conflict of opinion which we find raging around us.

“Normal science” means research firmly based upon one or more past scientific achievements, achievements that some particular scientific community acknowledges for a time as supplying the foundation for its further practice.

“On doit etre etonné ([Abbé Raynal]says) que l'Amerique n’ait pas encore produit un bon poëte, un habile mathematicien, un homme de génie dans un seul art, ou une seule science.” …“America has not yet produced one good poet.” When we shall have existed as a people as long as the Greeks did before they produced a Homer, the Romans a Virgil, the French a Racine and Voltaire, the English a Shakespeare and Milton, should this reproach be still true, we will enquire from what unfriendly causes it has proceeded, that the other countries of Europe and quarters of the earth shall not have inscribed any name in the roll of poets. But neither has America produced “one able mathematician, one man of genius in a single art or a single science.” … In physics we have produced a [Benjamin] Franklin, than whom no one of the present age has made more important discoveries, nor has enriched philosophy with more, or more ingenious solutions of the phaenomena, of nature. … [The quadrant invented by Godfrey, an American also, and with the aid of which the European nations traverse the globe, is called Hadley’s quadrant.] … We have supposed Mr. [David] Rittenhouse second to no astronomer living: that in genius he must be the first, because he is self-taught. As an artist he has exhibited as great a proof of mechanical genius as the world has ever produced. … We therefore suppose, that this reproach is as unjust as it is unkind; and that, of the geniuses which adorn the present age, America contributes its full share. [Compared to the much larger populations of European countries.]

“Science in itself” is nothing, for it exists only in the human beings who are its bearers.

[A friend at Cambridge] told me that Helmholtz had been a medical doctor before he became a physicist. It thereupon occurred to me that Helmholtz had eaten the meal of life in the wrong order, and that I would like to spend the first half of my life under the strict discipline of physics, and afterwards to apply that training to researches on living things.

[About research with big particle accelerators such as the Large Hadron Collider.] I think the primary justification for this sort of science that we do is fundamental human curiosity. ... It's true, of course, that every previous generation that's made some breakthrough in understanding nature has seen those discoveries translated into new technologies, new possibilities for the human race. That may well happen with the Higgs boson. Quite frankly, at the moment I don't see how you can use the Higgs boson for anything useful.

[Allowing embryonic stem cell research] … is also likely to lead to human cloning and the harvesting of body parts from babies conceived for this purpose.
An example of extreme prolife religious conservative opposition confusing public opinion.

[An outsider views a scientist] as a type of unscrupulous opportunist: he appears as a realist, insofar as he seeks to describe the world independent of the act of perception; as idealist insofar as he looks upon the concepts and theories as the free inventions of the human spirit (not logically derivable from that which is empirically given); as positivist insofar as he considers his concepts and theories justified only to the extent to which they furnish a logical representation of relations among sense experiences. He may even appear as Platonist or Pythagorean insofar as he considers the viewpoint of logical simplicity as an indispensable and effective tool of his research.

[At DuPont,] I was very fortunate that I worked under men who were very much interested in making discoveries and inventions. They were very much interested in what they were doing, and they left me alone. And I was able to experiment on my own, and I found this very stimulating. It appealed to the creative person in me.

[Before the time of Benjamin Peirce it never occurred to anyone that mathematical research] was one of the things for which a mathematical department existed. Today it is a commonplace in all the leading universities. Peirce stood alone—a mountain peak whose absolute height might be hard to measure, but which towered above all the surrounding country.

[Edison] definitely ended the distinction between the theoretical man of science and the practical man of science, so that today we think of scientific discoveries in connection with their possible present or future application to the needs of man. He took the old rule-of-thumb methods out of industry and substituted exact scientific knowledge, while, on the other hand, he directed scientific research into useful channels.

[For] men to whom nothing seems great but reason ... nature ... is a cosmos, so admirable, that to penetrate to its ways seems to them the only thing that makes life worth living. These are the men whom we see possessed by a passion to learn ... Those are the natural scientific men; and they are the only men that have any real success in scientific research.

[I doubt that in today's world, I and Francis Crick would ever have had our Eureka moment.] I recently went to my staircase at Clare College, Cambridge and there were women there! he said, with an enormous measure of retrospective sexual frustration. There have been a lot of convincing studies recently about the loss of productivity in the Western male. It may be that entertainment culture now is so engaging that it keeps people satisfied. We didn't have that. Science was much more fun than listening to the radio. When you are 16 or 17 and in that inherently semi-lonely period when you are deciding whether to be an intellectual, many now don't bother.
(Response when asked how he thought the climate of scientific research had changed since he made his discovery of the structure of life in 1953.)

[In research on bacteria metabolism] we have indeed much the same position as an observer trying to gain an idea of the life of a household by careful scrutiny of the persons and material arriving or leaving the house; we keep accurate records of the foods and commodities left at the door and patiently examine the contents of the dust-bin and endeavour to deduce from such data the events occurring within the closed doors.

[In the case of research director, Willis R. Whitney, whose style was to give talented investigators as much freedom as possible, you may define “serendipity” as] the art of profiting from unexpected occurrences. When you do things in that way you get unexpected results. Then you do something else and you get unexpected results in another line, and you do that on a third line and then all of a sudden you see that one of these lines has something to do with the other. Then you make a discovery that you never could have made by going on a direct road.

[It was] a lot of fun and we were so absorbed trying to do a good job that we didn’t think of the dangers. Until later on when people were saying, “You were sitting on top of all that hydrogen and oxygen.” Those tanks were right outside, the control room’s right there. I mean now, like up at Plum Brook, the control room for B-2 is like half a mile away. We were fifty feet away.

[Karen] Uhlenbeck’s research has led to revolutionary advances at the intersection of mathematics and physics. Her pioneering insights have applications across a range of fascinating subjects, from string theory, which may help explain the nature of reality, to the geometry of space-time.

[King Hiero II] requested Archimedes to consider [whether a crown was pure gold or alloyed with silver]. The latter, while the case was still on his mind, happened to go to the bath, and on getting into a tub observed that the more his body sank into it the more water ran out over the tub. As this pointed out the way to explain the case in question, without a moment’s delay, and transported with joy, he jumped out of the tub and rushed home naked, crying with a loud voice that he had found what he was seeking; for as he ran he shouted repeatedly in Greek, “Eὕρηκα, εὕρηκα.”

[L]et us not overlook the further great fact, that not only does science underlie sculpture, painting, music, poetry, but that science is itself poetic. The current opinion that science and poetry are opposed is a delusion. … On the contrary science opens up realms of poetry where to the unscientific all is a blank. Those engaged in scientific researches constantly show us that they realize not less vividly, but more vividly, than others, the poetry of their subjects. Whoever will dip into Hugh Miller’s works on geology, or read Mr. Lewes's “Seaside Studies,” will perceive that science excites poetry rather than extinguishes it. And whoever will contemplate the life of Goethe will see that the poet and the man of science can co-exist in equal activity. Is it not, indeed, an absurd and almost a sacrilegious belief that the more a man studies Nature the less he reveres it? Think you that a drop of water, which to the vulgar eye is but a drop of water, loses anything in the eye of the physicist who knows that its elements are held together by a force which, if suddenly liberated, would produce a flash of lightning? Think you that what is carelessly looked upon by the uninitiated as a mere snow-flake, does not suggest higher associations to one who has seen through a microscope the wondrously varied and elegant forms of snow-crystals? Think you that the rounded rock marked with parallel scratches calls up as much poetry in an ignorant mind as in the mind of a geologist, who knows that over this rock a glacier slid a million years ago? The truth is, that those who have never entered upon scientific pursuits know not a tithe of the poetry by which they are surrounded. Whoever has not in youth collected plants and insects, knows not half the halo of interest which lanes and hedge-rows can assume. Whoever has not sought for fossils, has little idea of the poetical associations that surround the places where imbedded treasures were found. Whoever at the seaside has not had a microscope and aquarium, has yet to learn what the highest pleasures of the seaside are. Sad, indeed, is it to see how men occupy themselves with trivialities, and are indifferent to the grandest phenomena—care not to understand the architecture of the Heavens, but are deeply interested in some contemptible controversy about the intrigues of Mary Queen of Scots!—are learnedly critical over a Greek ode, and pass by without a glance that grand epic written by the finger of God upon the strata of the Earth!

[Locating, from scratch, the gene related to a disease is like] trying to find a burned-out light bulb in a house located somewhere between the East and West coasts without knowing the state, much less the town or street the house is on.

[M]y work, which I’ve done for a long time, was not pursued in order to gain the praise I now enjoy, but chiefly from a craving after knowledge, which I notice resides in me more than in most other men. And therewithal, whenever I found out anything remarkable, I have thought it my duty to put down my discovery on paper, so that all ingenious people might be informed thereof.

[Modern science] passed through a long period of uncertainty and inconclusive experiment, but as the instrumental aids to research improved, and the results of observation accumulated, phantoms of the imagination were exorcised, idols of the cave were shattered, trustworthy materials were obtained for logical treatment, and hypotheses by long and careful trial were converted into theories.

[My research] throve best under adversity … in Germany in the middle 1930s under the Nazis when things became quite unpleasant and official seminars became dull. … We had a little private club… theoretical physicists and biologists. The discussions we had at that time have had a remarkable long-range effect, an effect that astonished us all. This was one adverse situation. Like the great Plague in Florence in 1348, which is the background setting for Bocaccio's Decameron.

[On research] It’s got to be fun. I don't think anybody should tell you that he’s slogged his way through 25 years on a problem and there's only one reward at the end, and that's the value of the Hubble constant. That’s a bunch of hooey. The reward is learning all the wonderful properties of the things that don’t work.

[On the practical applications of particle physics research with the Large Hadron Collider.] Sometimes the public says, “What's in it for Numero Uno? Am I going to get better television reception? Am I going to get better Internet reception?” Well, in some sense, yeah. … All the wonders of quantum physics were learned basically from looking at atom-smasher technology. … But let me let you in on a secret: We physicists are not driven to do this because of better color television. … That's a spin-off. We do this because we want to understand our role and our place in the universe.

[Otto Struve] made the remark once that he never looked at the spectrum of a star, any star, where he didn’t find something important to work on.

[Pure research] is worth every penny it costs.

[Richard Drew] always encouraged his people to pursue ideas… He said, “If it’s a dumb idea, you’ll find out. You’ll smack into that brick wall, then you’ll stagger back and see another opportunity that you wouldn’t have seen otherwise.”

[Richard Drew] created a greenhouse environment—a skunkworks—where we could do anything, try anything. When you’re an oddball in a permissive environment, very often things turn out well.

[Scientific research reveals] the majestic spectacle of the order of nature gradually unfolding itself to man’s consciousness and placing in his hands the implements of ever augmenting power to control his destinies and attain that ultimate comprehension of the universe which has in all ages constituted the supreme aspiration of man.

[T]he yeoman’s work in any science, and especially physics, is done by the experimentalist, who must keep the theoreticians honest.

[Technical courage means the] physician-scientist must be brave enough to adopt new methods. It is far too easy to learn one technique and then to repeat the same experiment over and over. In this fashion one can write many papers, receive large research grants, and remain solidly rooted in the middle of a scientific field. But the true innovator has the confidence to drop one set of experimental crutches and leap to another when he or she must move forward.

[The purpose of flight research] is to separate the real from the imagined problems and to make known the overlooked and the unexpected.

[The surplus of basic knowledge of the atomic nucleus was] largely used up [during the war with the atomic bomb as the dividend.] We must, without further delay restore this surplus in preparation for the important peacetime job for the nucleus - power production. ... Many of the proposed applications of atomic power - even for interplanetary rockets - seem to be within the realm of possibility provided the economic factor is ruled out completely, and the doubtful physical and chemical factors are weighted heavily on the optimistic side. ... The development of economic atomic power is not a simple extrapolation of knowledge gained during the bomb work. It is a new and difficult project to reach a satisfactory answer. Needless to say, it is vital that the atomic policy legislation now being considered by the congress recognizes the essential nature of this peacetime job, and that it not only permits but encourages the cooperative research-engineering effort of industrial, government and university laboratories for the task. ... We must learn how to generate the still higher energy particles of the cosmic rays - up to 1,000,000,000 volts, for they will unlock new domains in the nucleus.

[There] are cases where there is no dishonesty involved but where people are tricked into false results by a lack of understanding about what human beings can do to themselves in the way of being led astray by subjective effects, wishful thinking or threshold interactions. These are examples of pathological science. These are things that attracted a great deal of attention. Usually hundreds of papers have been published upon them. Sometimes they have lasted for fifteen or twenty years and then they gradually die away.
[Coining the term “pathological science” for the self-deceiving application of science to a phenomenon that doesn't exist.]

[Vikram Sarabhai] informed the whole of his team about any new project and started working on it only after having discussed it with everyone.

[Vikram Sarabhai] said that if we want to establish ourselves in the world, we have to be self-sufficient and search for new ideas and techniques.

[Vikram Sarabhai] said that the performer must have emotional attachment with the project along with the physical: otherwise one can’t attain dedication and devotion for it.

[Recalling Professor Ira Remsen's remarks (1895) to a group of his graduate students about to go out with their degrees into the world beyond the university:]
He talked to us for an hour on what was ahead of us; cautioned us against giving up the desire to push ahead by continued study and work. He warned us against allowing our present accomplishments to be the high spot in our lives. He urged us not to wait for a brilliant idea before beginning independent research, and emphasized the fact the Lavoisier's first contribution to chemistry was the analysis of a sample of gypsum. He told us that the fields in which the great masters had worked were still fruitful; the ground had only been scratched and the gleaner could be sure of ample reward.

[When recording electrical impulses from a frog nerve-muscle preparation seemed to show a tiresomely oscillating electrical artefact—but only when the muscle was hanging unsupported.] The explanation suddenly dawned on me ... a muscle hanging under its own weight ought, if you come to think of it, to be sending sensory impulses up the nerves coming from the muscle spindles ... That particular day’s work, I think, had all the elements that one could wish for. The new apparatus seemed to be misbehaving very badly indeed, and I suddenly found it was behaving so well that it was opening up an entire new range of data ... it didn’t involve any particular hard work, or any particular intelligence on my part. It was just one of those things which sometimes happens in a laboratory if you stick apparatus together and see what results you get.

Clarke's First Law: When a distinguished but elderly scientist states that something is possible, he is almost certainly right. When he states that something is impossible, he is very probably wrong.

Clarke's Second Law: The only way of discovering the limits of the possible is to venture a little way past them into the impossible.

Drosophila melanogaster has been more extensively used in the study of genetics than any other organism, and the theory of heredity that is now generally accepted is based chiefly on the results obtained with this fly. … Not only has Drosophila been the most productive material for research in the subject, but it is now the standard object for laboratory instruction, and is used as such in many colleges and universities.

Ihre Arbeit ist gekrönt worden mit dem Nobel Preis für Otto Hahn.
Her work has been crowned by the Nobel Prize for Otto Hahn.

Indiana Jones: Archaeology is the search for fact… not truth. If it’s truth you're looking for, Dr. Tyree’s philosophy class is right down the hall. … So forget any ideas you've got about lost cities, exotic travel, and digging up the world. We do not follow maps to buried treasure, and “X” never, ever marks the spot. Seventy percent of all archaeology is done in the library. Research. Reading.

La science, mon garçon, est faite d’erreurs, mais d’erreurs qu’il est bon de commettre, car elles mènent peu à peu à la vérité.
Science, my boy, is composed of errors, but errors that it is right to make, for they lead step by step to the truth.

Les Leucocytes Et L'esprit De Sacrifice. — Il semble, d'après les recherches de De Bruyne (Phagocytose, 1895) et de ceux qui le citent, que les leucocytes des Lamellibranches — probablement lorsqu'ils ont phagocyté, qu'ils se sont chargés de résidus et de déchets, qu'ils ont, en un mot, accompli leur rôle et bien fait leur devoir — sortent du corps de l'animal et vont mourir dans le milieu ambiant. Ils se sacrifient. Après avoir si bien servi l'organisme par leur activité, ils le servent encore par leur mort en faisant place aux cellules nouvelles, plus jeunes.
N'est-ce pas la parfaite image du désintéressement le plus noble, et n'y a-t-il point là un exemple et un modèle? Il faut s'en inspirer: comme eux, nous sommes les unités d'un grand corps social; comme eux, nous pouvons le servir et envisager la mort avec sérénité, en subordonnant notre conscience individuelle à la conscience collective. (30 Jan 1896)
Leukocytes and The Spirit Of Sacrifice. - It seems, according to research by De Bruyne (Phagocytosis, 1885) and those who quote it, that leukocytes of Lamellibranches [bivalves] - likely when they have phagocytized [ingested bacteria], as they become residues and waste, they have, in short, performed their role well and done their duty - leave the body of the animal and will die in the environment. They sacrifice themselves. Having so well served the body by their activities, they still serve in their death by making room for new younger cells.
Isn't this the perfect image of the noblest selflessness, and thereby presents an example and a model? It should be inspiring: like them, we are the units of a great social body, like them, we can serve and contemplate death with equanimity, subordinating our individual consciousness to collective consciousness.

Nisi credideritis, non intelligitis.
Unless you believe, you will not understand.

Nun wie gehts?
How goes it?
[Werner’s perennial salutation to research students, hence his nickname, Professor Nunwiegehts.]

On examinations: Das Wissen ist der Tad der Forschung.
Knowledge is the death of research.
Nernst's motto.

~~[Misattributed]~~ Somewhere, something incredible is waiting to be known.

~~[Unverified attribution]~~ Most people stop looking when they find the proverbial needle in the haystack. I would continue looking to see if there were other needles.

A biologist, if he wishes to know how many toes a cat has, does not "frame the hypothesis that the number of feline digital extremities is 4, or 5, or 6," he simply looks at a cat and counts. A social scientist prefers the more long-winded expression every time, because it gives an entirely spurious impression of scientificness to what he is doing.

A century ago astronomers, geologists, chemists, physicists, each had an island of his own, separate and distinct from that of every other student of Nature; the whole field of research was then an archipelago of unconnected units. To-day all the provinces of study have risen together to form a continent without either a ferry or a bridge.

A drop from the nose of Fleming, who had a cold, fell onto an agar plate where large yellow colonies of a contaminant had grown, and lysosyme was discovered. He made this important discovery because when he saw that the colonies of the contaminant were fading, his mind went straight to the right cause of the phenomenon he was observing—that the drop from his nose contained a lytic substance. And also immediately, he thought that this substance might be present in many secretions and tissues of the body. And he found this was so—the substance was in tears, saliva, leucocytes, skin, fingernails, mother's milk—thus very widely distributed in amounts and also in plants.

A fallacy entertained by many … is that any problem can be solved by gathering enough scientists and giving them enough money. To solve the problem of the common cold assemble a great institution, fill it with scientists and money, and soon we will have no more colds! It is folly to thus proceed. The great scientific steps forward originate in the minds of gifted scientists, not in the minds of promoters. The best way to proceed is to be sure that really inspired scientists have what they need to work with, and leave them alone

A good deal of my research in physics has consisted in not setting out to solve some particular problem, but simply examining mathematical quantities of a kind that physicists use and trying to fit them together in an interesting way, regardless of any application that the work may have. It is simply a search for pretty mathematics. It may turn out later to have an application. Then one has good luck. At age 78.

A life that stood out as a gospel of self-forgetting service.
He could have added fortune to fame but caring for neither he found happiness and honor in being helpful to the world.
The centre of his world was the south where he was born in slavery some 79 years ago and where he did his work as a creative scientist.

A mind exclusively bent upon the idea of utility necessarily narrows the range of the imagination. For it is the imagination which pictures to the inner eye of the investigator the indefinitely extending sphere of the possible,—that region of hypothesis and explanation, of underlying cause and controlling law. The area of suggestion and experiment is thus pushed beyond the actual field of vision.

A number of years ago, when I was a freshly-appointed instructor, I met, for the first time, a certain eminent historian of science. At the time I could only regard him with tolerant condescension.
I was sorry of the man who, it seemed to me, was forced to hover about the edges of science. He was compelled to shiver endlessly in the outskirts, getting only feeble warmth from the distant sun of science- in-progress; while I, just beginning my research, was bathed in the heady liquid heat up at the very center of the glow.
In a lifetime of being wrong at many a point, I was never more wrong. It was I, not he, who was wandering in the periphery. It was he, not I, who lived in the blaze.
I had fallen victim to the fallacy of the “growing edge;” the belief that only the very frontier of scientific advance counted; that everything that had been left behind by that advance was faded and dead.
But is that true? Because a tree in spring buds and comes greenly into leaf, are those leaves therefore the tree? If the newborn twigs and their leaves were all that existed, they would form a vague halo of green suspended in mid-air, but surely that is not the tree. The leaves, by themselves, are no more than trivial fluttering decoration. It is the trunk and limbs that give the tree its grandeur and the leaves themselves their meaning.
There is not a discovery in science, however revolutionary, however sparkling with insight, that does not arise out of what went before. “If I have seen further than other men,” said Isaac Newton, “it is because I have stood on the shoulders of giants.”

A persistent and age-old instinct makes us want to wander
Into regions yet untrod
And read what is still unread
In the manuscripts of God.

A provision of endless apparatus, a bustle of infinite enquiry and research, or even the mere mechanical labour of copying, may be employed, to evade and shuffle off real labour, — the real labour of thinking.

A recognized fact which goes back to the earliest times is that every living organism is not the sum of a multitude of unitary processes, but is, by virtue of interrelationships and of higher and lower levels of control, an unbroken unity. When research, in the efforts of bringing understanding, as a rule examines isolated processes and studies them, these must of necessity be removed from their context. In general, viewed biologically, this experimental separation involves a sacrifice. In fact, quantitative findings of any material and energy changes preserve their full context only through their being seen and understood as parts of a natural order.

A research journal serves that narrow borderland which separates the known from the unknown.

A research laboratory jealous of its reputation has to develop less formal, more intimate ways of forming a corporate judgment of the work its people do. The best laboratories in university departments are well known for their searching, mutual questioning.

A research problem is not solved by apparatus; it is solved in a man's head.

A scientist can be productive in various ways. One is having the ability to plan and carry out experiments, but the other is having the ability to formulate new ideas, which can be about what experiments can be carried out … by making [the] proper calculations. Individual scientists who are successful in their work are successful for different reasons.

A space station will permit quantum leaps in our research in science, communications, in metals, and in lifesaving medicines which could be manufactured only in space.

A student who wishes now-a-days to study geometry by dividing it sharply from analysis, without taking account of the progress which the latter has made and is making, that student no matter how great his genius, will never be a whole geometer. He will not possess those powerful instruments of research which modern analysis puts into the hands of modern geometry. He will remain ignorant of many geometrical results which are to be found, perhaps implicitly, in the writings of the analyst. And not only will he be unable to use them in his own researches, but he will probably toil to discover them himself, and, as happens very often, he will publish them as new, when really he has only rediscovered them.

A wise man in China asked his gardener to plant a shrub. The gardener objected that it only flowered once in a hundred years. “In that case,” said the wise man, “plant it immediately.” [On the importance of fundamental research.]

Above all, I regret that scientific experiments—some of them mine—should have produced such a terrible weapon as the hydrogen bomb. Regret, with all my soul, but not guilt.

Abstruse mathematical researches … are … often abused for having no obvious physical application. The fact is that the most useful parts of science have been investigated for the sake of truth, and not for their usefulness. A new branch of mathematics, which has sprung up in the last twenty years, was denounced by the Astronomer Royal before the University of Cambridge as doomed to be forgotten, on account of its uselessness. Now it turns out that the reason why we cannot go further in our investigations of molecular action is that we do not know enough of this branch of mathematics.

Aeroplanes are not designed by science, but by art in spite of some pretence and humbug to the contrary. I do not mean to suggest that engineering can do without science, on the contrary, it stands on scientific foundations, but there is a big gap between scientific research and the engineering product which has to be bridged by the art of the engineer.

After a short period spent in Brussels as a guest of a neurological institute, I returned to Turin on the verge of the invasion of Belgium by the German army, Spring 1940, to join my family. The two alternatives left then to us were either to emigrate to the United States, or to pursue some activity that needed neither support nor connection with the outside Aryan world where we lived. My family chose this second alternative. I then decided to build a small research unit at home and installed it in my bedroom.

After the discovery of spectral analysis no one trained in physics could doubt the problem of the atom would be solved when physicists had learned to understand the language of spectra. So manifold was the enormous amount of material that has been accumulated in sixty years of spectroscopic research that it seemed at first beyond the possibility of disentanglement. An almost greater enlightenment has resulted from the seven years of Röntgen spectroscopy, inasmuch as it has attacked the problem of the atom at its very root, and illuminates the interior. What we are nowadays hearing of the language of spectra is a true 'music of the spheres' in order and harmony that becomes ever more perfect in spite of the manifold variety. The theory of spectral lines will bear the name of Bohr for all time. But yet another name will be permanently associated with it, that of Planck. All integral laws of spectral lines and of atomic theory spring originally from the quantum theory. It is the mysterious organon on which Nature plays her music of the spectra, and according to the rhythm of which she regulates the structure of the atoms and nuclei.

All human affairs follow nature's great analogue, the growth of vegetation. There are three periods of growth in every plant. The first, and slowest, is the invisible growth by the root; the second and much accelerated is the visible growth by the stem; but when root and stem have gathered their forces, there comes the third period, in which the plant quickly flashes into blossom and rushes into fruit.
The beginnings of moral enterprises in this world are never to be measured by any apparent growth. ... At length comes the sudden ripeness and the full success, and he who is called in at the final moment deems this success his own. He is but the reaper and not the labourer. Other men sowed and tilled and he but enters into their labours.

All palaetiological sciences, all speculations which attempt to ascend from the present to the remote past, by the chain of causation, do also, by an inevitable consequence, urge us to look for the beginning of the state of things which we thus contemplate; but in none of these cases have men been able, by the aid of science, to arrive at a beginning which is homogeneous with the known course of events. The first origin of language, of civilization, of law and government, cannot be clearly made out by reasoning and research; and just as little, we may expect, will a knowledge of the origin of the existing and extinct species of plants and animals, be the result of physiological and geological investigation.

All that concerns the Mediterranean is of the deepest interest to civilized man, for the history of its progress is the history of the development of the world; the memory of the great men who have lived and died around its banks; the recollection of the undying works that have come thence to delight us for ever; the story of patient research and brilliant discoveries connected with every physical phenomenon presented by its waves and currents, and with every order of creatures dwelling in and around its waters.

Although I must say that research problems I worked on were frequently the result of serendipity and often grew out of my interest in some species or some environment which I found to be particularly appealing—marine birds and tropical islands for example.

Although such research [into the paranormal] has yet to produce anything in the way of a repeatable controlled experiment, its practitioners argue that its revolutionary potentialities justify its continuation. My own feeling is that after a century of total failure it has become a bloody bore.

Always preoccupied with his profound researches, the great Newton showed in the ordinary-affairs of life an absence of mind which has become proverbial. It is related that one day, wishing to find the number of seconds necessary for the boiling of an egg, he perceived, after waiting a minute, that he held the egg in his hand, and had placed his seconds watch (an instrument of great value on account of its mathematical precision) to boil!
This absence of mind reminds one of the mathematician Ampere, who one day, as he was going to his course of lectures, noticed a little pebble on the road; he picked it up, and examined with admiration the mottled veins. All at once the lecture which he ought to be attending to returned to his mind; he drew out his watch; perceiving that the hour approached, he hastily doubled his pace, carefully placed the pebble in his pocket, and threw his watch over the parapet of the Pont des Arts.

American scientific companies are cross-breeding humans and animals and coming up with mice with fully functioning human brains.

Among those whom I could never pursuade to rank themselves with idlers, and who speak with indignation of my morning sleeps and nocturnal rambles, one passes the day in catching spiders, that he may count their eyes with a microscope; another exhibits the dust of a marigold separated from the flower with a dexterity worthy of Leuwenhoweck himself. Some turn the wheel of electricity; some suspend rings to a lodestone, and find that what they did yesterday, they can do again to-day.—Some register the changes of the wind, and die fully convinced that the wind is changeable.—There are men yet more profound, who have heard that two colorless liquors may produce a color by union, and that two cold bodies will grow hot of they are mingled: they mingle them, and produce the effect expected, say it is strange, and mingle them again.

Ampère was a mathematician of various resources & I think might rather be called excentric [sic] than original. He was as it were always mounted upon a hobby horse of a monstrous character pushing the most remote & distant analogies. This hobby horse was sometimes like that of a child ['s] made of heavy wood, at other times it resembled those [?] shapes [?] used in the theatre [?] & at other times it was like a hypogrif in a pantomime de imagie. He had a sort of faith in animal magnetism & has published some refined & ingenious memoirs to prove the identity of electricity & magnetism but even in these views he is rather as I said before excentric than original. He has always appeared to me to possess a very discursive imagination & but little accuracy of observation or acuteness of research.

An intelligent patient, private or otherwise, to whom you have taken the trouble to explain the nature of the investigation, makes the best laboratory animal.

And so, after many years, victory has come, and the romance of exploration, of high hopes and bitter disappointment, will in a few years simply be recorded in the text-books of organic chemistry in a few terse sentences.

And when with excellent Microscopes I discern in otherwise invisible Objects the Inimitable Subtlety of Nature’s Curious Workmanship; And when, in a word, by the help of Anatomicall Knives, and the light of Chymicall Furnaces, I study the Book of Nature, and consult the Glosses of Aristotle, Epicurus, Paracelsus, Harvey, Helmont, and other learn'd Expositors of that instructive Volumne; I find my self oftentimes reduc’d to exclaim with the Psalmist, How manifold are thy works, O Lord? In wisdom hast thou made them all.

Animals, even plants, lie to each other all the time, and we could restrict the research to them, putting off the real truth about ourselves for the several centuries we need to catch our breath. What is it that enables certain flowers to resemble nubile insects, or opossums to play dead, or female fireflies to change the code of their flashes in order to attract, and then eat, males of a different species?

Any chemist reading this book can see, in some detail, how I have spent most of my mature life. They can become familiar with the quality of my mind and imagination. They can make judgements about my research abilities. They can tell how well I have documented my claims of experimental results. Any scientist can redo my experiments to see if they still work—and this has happened! I know of no other field in which contributions to world culture are so clearly on exhibit, so cumulative, and so subject to verification.

Anybody who has been seriously engaged in scientific work of any kind realizes that over the entrance to the gates of the temple of science are written the words: Ye must have faith. It is a quality which the scientist cannot dispense with.

Anyone of common mental and physical health can practice scientific research. … Anyone can try by patient experiment what happens if this or that substance be mixed in this or that proportion with some other under this or that condition. Anyone can vary the experiment in any number of ways. He that hits in this fashion on something novel and of use will have fame. … The fame will be the product of luck and industry. It will not be the product of special talent.

Anything worth doing is worth doing twice, the first time quick and dirty and the second time the best way you can.

Applied research generates improvements, not breakthroughs. Great scientific advances spring from pure research. Even scientists renowned for their “useful” applied discoveries often achieved success only when they abandoned their ostensible applied-science goal and allowed their minds to soar—as when Alexander Fleming, “just playing about,” refrained from throwing away green molds that had ruined his experiment, studied them, and discovered penicillin. Or when C. A. Clarke, a physician affiliated with the University of Liverpool, became intrigued in the 1950s by genetically created color patterns that emerged when he cross-bred butterflies as a hobby. His fascination led him—“by the pleasant route of pursuing idle curiosity”—to the successful idea for preventing the sometimes fatal anemia that threatened babies born of a positive-Rhesus-factor father and a negative-Rhesus-factor mother.

As a different, but perhaps more common, strategy for the suppression of novelty, we may admit the threatening object to our midst, but provide an enveloping mantle of ordinary garb… . This kind of cover-up, so often amusing in our daily lives, can be quite dangerous in science, for nothing can stifle originality more effectively than an ordinary mantle placed fully and securely over an extraordinary thing.

As a man who has devoted his whole life to the most clear headed science, to the study of matter, I can tell you as a result of my research about atoms this much: There is no matter as such. All matter originates and exists only by virtue of a force which brings the particle of an atom to vibration and holds this most minute solar system of the atom together. … We must assume behind this force the existence of a conscious and intelligent mind. This mind is the matrix of all matter.

As a scientist and geneticist I started to feel that science would probably soon reach the point where its interference into the life processes would be counterproductive if a properly designed governing policy was not implemented. A heavily overcrowded planet, ninety-five percent urbanized with nuclear energy as the main source of energy and with all aspects of life highly computerized, is not too pleasant a place for human life. The life of any individual soon will be predictable from birth to death. Medicine, able to cure almost everything, will make the load of accumulated defects too heavy in the next two or three centuries. The artificial prolongation of life, which looked like a very bright idea when I started research in aging about twenty-five years ago, has now lost its attractiveness for me. This is because I now know that the aging process is so multiform and complex that the real technology and chemistry of its prevention by artificial interference must be too complex and expensive. It would be the privilege of a few, not the method for the majority. I also was deeply concerned about the fact that most research is now either directly or indirectly related to military projects and objectives for power.

As experimentalists, we always can find something to do, even if we have to work with string and sealing wax.

As in the domains of practical life so likewise in science there has come about a division of labor. The individual can no longer control the whole field of mathematics: it is only possible for him to master separate parts of it in such a manner as to enable him to extend the boundaries of knowledge by creative research.

As our researches have made clear, an animal high in the organic scale only reaches this rank by passing through all the intermediate states which separate it from the animals placed below it. Man only becomes man after traversing transitional organisatory states which assimilate him first to fish, then to reptiles, then to birds and mammals.

As was predicted at the beginning of the Human Genome Project, getting the sequence will be the easy part as only technical issues are involved. The hard part will be finding out what it means, because this poses intellectual problems of how to understand the participation of the genes in the functions of living cells.

At bottom each “exact” science is, and must be speculative, and its chief tool of research, too rarely used with both courage and judgement, is the regulated imagination.

At the entrance to the observatory Stjerneborg located underground, Tycho Brahe built a Ionic portal. On top of this were three sculptured lions. On both sides were inscriptions and on the backside was a longer inscription in gold letters on a porfyr stone: Consecrated to the all-good, great God and Posterity. Tycho Brahe, Son of Otto, who realized that Astronomy, the oldest and most distinguished of all sciences, had indeed been studied for a long time and to a great extent, but still had not obtained sufficient firmness or had been purified of errors, in order to reform it and raise it to perfection, invented and with incredible labour, industry, and expenditure constructed various exact instruments suitable for all kinds of observations of the celestial bodies, and placed them partly in the neighbouring castle of Uraniborg, which was built for the same purpose, partly in these subterranean rooms for a more constant and useful application, and recommending, hallowing, and consecrating this very rare and costly treasure to you, you glorious Posterity, who will live for ever and ever, he, who has both begun and finished everything on this island, after erecting this monument, beseeches and adjures you that in honour of the eternal God, creator of the wonderful clockwork of the heavens, and for the propagation of the divine science and for the celebrity of the fatherland, you will constantly preserve it and not let it decay with old age or any other injury or be removed to any other place or in any way be molested, if for no other reason, at any rate out of reverence to the creator’s eye, which watches over the universe. Greetings to you who read this and act accordingly. Farewell!

Attempt the end and never stand to doubt;
Nothing's so hard, but search will find it out.

AZT stood up and said, 'Stop your pessimism. Stop your sense of futility. Go back to the lab. Go back to development. Go back to clinical trials. Things will work.'
[On the impact of AZT emerging as the long-sought first significant AIDS drug.]

Bankers regard research as most dangerous a thing that makes banking hazardous due to the rapid changes it brings about in industry.

Basic research at universities comes in two varieties: research that requires big bucks and research that requires small bucks. Big bucks research is much like government research and in fact usually is government research but done for the government under contract. Like other government research, big bucks academic research is done to understand the nature and structure of the universe or to understand life, which really means that it is either for blowing up the world or extending life, whichever comes first. Again, that's the government's motivation. The universities' motivation for conducting big bucks research is to bring money in to support professors and graduate students and to wax the floors of ivy-covered buildings. While we think they are busy teaching and learning, these folks are mainly doing big bucks basic research for a living, all the while priding themselves on their terrific summer vacations and lack of a dress code.
Smalls bucks research is the sort of thing that requires paper and pencil, and maybe a blackboard, and is aimed primarily at increasing knowledge in areas of study that don't usually attract big bucks - that is, areas that don't extend life or end it, or both. History, political science, and romance languages are typically small bucks areas of basic research. The real purpose of small bucks research to the universities is to provide a means of deciding, by the quality of their small bucks research, which professors in these areas should get tenure.

Basic research is like shooting an arrow into the air and, where it lands, painting a target.

Basic research is not the same as development. A crash program for the latter may be successful; but for the former it is like trying to make nine women pregnant at once in the hope of getting a baby in a month’s time.

Basic research is what I am doing when I don't know what I am doing.

Basic research may seem very expensive. I am a well-paid scientist. My hourly wage is equal to that of a plumber, but sometimes my research remains barren of results for weeks, months or years and my conscience begins to bother me for wasting the taxpayer’s money. But in reviewing my life’s work, I have to think that the expense was not wasted.
Basic research, to which we owe everything, is relatively very cheap when compared with other outlays of modern society. The other day I made a rough calculation which led me to the conclusion that if one were to add up all the money ever spent by man on basic research, one would find it to be just about equal to the money spent by the Pentagon this past year.

Basic scientific research is scientific capital.

Beware of finding what you're looking for.
A favorite aphorism he often used.

Biological disciplines tend to guide research into certain channels. One consequence is that disciplines are apt to become parochial, or at least to develop blind spots, for example, to treat some questions as “interesting” and to dismiss others as “uninteresting.” As a consequence, readily accessible but unworked areas of genuine biological interest often lie in plain sight but untouched within one discipline while being heavily worked in another. For example, historically insect physiologists have paid relatively little attention to the behavioral and physiological control of body temperature and its energetic and ecological consequences, whereas many students of the comparative physiology of terrestrial vertebrates have been virtually fixated on that topic. For the past 10 years, several of my students and I have exploited this situation by taking the standard questions and techniques from comparative vertebrate physiology and applying them to insects. It is surprising that this pattern of innovation is not more deliberately employed.

Bohr’s standpoint, that a space-time description is impossible, I reject a limine. Physics does not consist only of atomic research, science does not consist only of physics, and life does not consist only of science. The aim of atomic research is to fit our empirical knowledge concerning it into our other thinking. All of this other thinking, so far as it concerns the outer world, is active in space and time. If it cannot be fitted into space and time, then it fails in its whole aim and one does not know what purpose it really serves.

Both social and biosocial factors are necessary to interpret crosscultural studies, with the general proviso that one’s research interest determines which elements, in what combinations, are significant for the provision of understanding.

But among all these many departments of research, these many branches of industry, new and old, which are being rapidly expanded, there is one dominating all others in importance—one which is of the greatest significance for the comfort and welfare, not to say for the existence, of mankind, and that is the electrical transmission of power.

But for twenty years previous to 1847 a force had been at work in a little county town of Germany destined to effect the education of Christendom, and at the same time to enlarge the boundaries of human knowledge, first in chemistry and the allied branches, then in every other one of the natural sciences. The place was Giessen; the inventor Liebig; the method, a laboratory for instruction and research.

But medicine has long had all its means to hand, and has discovered both a principle and a method, through which the discoveries made during a long period are many and excellent, while full discovery will be made, if the inquirer be competent, conduct his researches with knowledge of the discoveries already made, and make them his starting-point. But anyone who, casting aside and rejecting all these means, attempts to conduct research in any other way or after another fashion, and asserts that he has found out anything, is and has been victim of deception.

But the World being once fram’d, and the course of Nature establish’d, the Naturalist, (except in some few cases, where God, or Incorporeal Agents interpose), has recourse to the first Cause but for its general and ordinary Support and Influence, whereby it preserves Matter and Motion from Annihilation or Desition; and in explicating particular phenomena, considers onely the Size, Shape, Motion, (or want of it) Texture, and the resulting Qualities and Attributes of the small particles of Matter.

But when you come right down to it, the reason that we did this job is because it was an organic necessity. If you are a scientist you cannot stop such a thing. If you are a scientist you believe that it is good to find out how the world works; that it is good to find out what the realities are; that it is good to turn over to mankind at large the greatest possible power to control the world and to deal with it according to its lights and values.
Regarding the atomic bomb project.

But, because my private lectures and domestic pupils are a great hinderance and interruption of my studies, I wish to live entirely exempt from the former, and in great measure from the latter. … in short, I should wish to gain my bread from my writings.

By research in pure science I mean research made without any idea of application to industrial matters but solely with the view of extending our knowledge of the Laws of Nature. I will give just one example of the ‘utility’ of this kind of research, one that has been brought into great prominence by the War—I mean the use of X-rays in surgery. Now, not to speak of what is beyond money value, the saving of pain, or, it may be, the life of the wounded, and of bitter grief to those who loved them, the benefit which the state has derived from the restoration of so many to life and limb, able to render services which would otherwise have been lost, is almost incalculable. Now, how was this method discovered? It was not the result of a research in applied science starting to find an improved method of locating bullet wounds. This might have led to improved probes, but we cannot imagine it leading to the discovery of X-rays. No, this method is due to an investigation in pure science, made with the object of discovering what is the nature of Electricity. The experiments which led to this discovery seemed to be as remote from ‘humanistic interest’ —to use a much misappropriated word—as anything that could well be imagined. The apparatus consisted of glass vessels from which the last drops of air had been sucked, and which emitted a weird greenish light when stimulated by formidable looking instruments called induction coils. Near by, perhaps, were great coils of wire and iron built up into electro-magnets. I know well the impression it made on the average spectator, for I have been occupied in experiments of this kind nearly all my life, notwithstanding the advice, given in perfect good faith, by non-scientific visitors to the laboratory, to put that aside and spend my time on something useful.

By teaching us how to cultivate each ferment in its purity—in other words, by teaching us how to rear the individual organism apart from all others,—Pasteur has enabled us to avoid all these errors. And where this isolation of a particular organism has been duly effected it grows and multiplies indefinitely, but no change of it into another organism is ever observed. In Pasteur’s researches the Bacterium remained a Bacterium, the Vibrio a Vibrio, the Penicillium a Penicillium, and the Torula a Torula. Sow any of these in a state of purity in an appropriate liquid; you get it, and it alone, in the subsequent crop. In like manner, sow smallpox in the human body, your crop is smallpox. Sow there scarlatina, and your crop is scarlatina. Sow typhoid virus, your crop is typhoid—cholera, your crop is cholera. The disease bears as constant a relation to its contagium as the microscopic organisms just enumerated do to their germs, or indeed as a thistle does to its seed.

Cancer cells invade surrounding tissue, make their way into blood vessels, and spread throughout the body. What are they searching for? My guess is oxygen.

Cancer is a biological, not a statistical problem.

Charles Kettering ... said that from studying conventional text-books we fall into a rut and to escape from this takes as much effort as to solve the problem.

Chemical research conducts to the knowledge of philosophical truth, and forms the mind to philosophical enlargement and accuracy of thought, more happily than almost any other species of investigation in which the human intellect can be employed.

Chemistry is one of those branches of human knowledge which has built itself upon methods and instruments by which truth can presumably be determined. It has survived and grown because all its precepts and principles can be re-tested at any time and anywhere. So long as it remained the mysterious alchemy by which a few devotees, by devious and dubious means, presumed to change baser metals into gold, it did not flourish, but when it dealt with the fact that 56 g. of fine iron, when heated with 32 g. of flowers of sulfur, generated extra heat and gave exactly 88 g. of an entirely new substance, then additional steps could be taken by anyone. Scientific research in chemistry, since the birth of the balance and the thermometer, has been a steady growth of test and observation. It has disclosed a finite number of elementary reagents composing an infinite universe, and it is devoted to their inter-reaction for the benefit of mankind.