Applied research generates improvements, not breakthroughs. Great scientific advances spring from pure research. Even scientists renowned for their “useful” applied discoveries often achieved success only when they abandoned their ostensible applied-science goal and allowed their minds to soar—as when Alexander Fleming, “just playing about,” refrained from throwing away green molds that had ruined his experiment, studied them, and discovered penicillin. Or when C. A. Clarke, a physician affiliated with the University of Liverpool, became intrigued in the 1950s by genetically created color patterns that emerged when he cross-bred butterflies as a hobby. His fascination led him—“by the pleasant route of pursuing idle curiosity”—to the successful idea for preventing the sometimes fatal anemia that threatened babies born of a positive-Rhesus-factor father and a negative-Rhesus-factor mother.

Characteristically skeptical of the idea that living things would faithfully follow mathematical formulas, [Robert Harper] seized upon factors in corn which seemed to blend in the hybrid—rather than be represented by plus or minus signs, and put several seasons into throwing doubt upon the concept of immutable hypothetical units of inheritance concocted to account for selected results.

Einstein was wrong when he said, 'God does not play dice'. Consideration of black holes suggests, not only that God does play dice, but that he sometimes confuses us by throwing them where they can't be seen.

I believe myself to possess a most singular combination of qualities exactly fitted to make me pre-eminently a discoverer of the hidden realities of nature… the belief has been forced upon me…
Firstly: Owing to some peculiarity in my nervous system, I have perceptions of some things, which no one else has… and intuitive perception of… things hidden from eyes, ears, & ordinary senses…
Secondly: my sense reasoning faculties;
Thirdly: my concentration faculty, by which I mean the power not only of throwing my whole energy & existence into whatever I choose, but also of bringing to bear on anyone subject or idea, a vast apparatus from all sorts of apparently irrelevant & extraneous sources…
Well, here I have written what most people would call a remarkably mad letter; & yet certainly one of the most logical, sober-minded, cool, pieces of composition, (I believe), that I ever framed.

I could not help laughing at the ease with which he explained his process of deduction. “When I hear you give your reasons,” I remarked, “the thing always appears to me to be so ridiculously simple that I could easily do it myself, though at each successive instance of your reasoning I am baffled, until you explain your process. And yet I believe that my eyes are as good as yours.”
“Quite so,” he answered, lighting a cigarette, and throwing himself down into an arm-chair. “You see, but you do not observe. The distinction is clear. For example, you have frequently seen the steps which lead up from the hall to this room.”
“Frequently.”
“How often?”
“'Well, some hundreds of times.”
“Then how many are there?”
“How many! I don't know.”
“Quite so! You have not observed. And yet you have seen. That is just my point. Now, I know that there are seventeen steps, because I have both seen and observed.”

If I had to define life in a single phrase, I should clearly express my thought of throwing into relief one characteristic which, in my opinion, sharply differentiates biological science. I should say: life is creation.

In many ways the performances of Donald Trump remind me of male chimpanzees and their dominance rituals. In order to impress rivals, males seeking to rise in the dominance hierarchy perform spectacular displays: stamping, slapping the ground, dragging branches, throwing rocks. The more vigorous and imaginative the display, the faster the individual is likely to rise in the hierarchy, and the longer he is likely to maintain that position.

It is probably no exaggeration to suppose that in order to improve such an organ as the eye at all, it must be improved in ten different ways at once. And the improbability of any complex organ being produced and brought to perfection in any such way is an improbability of the same kind and degree as that of producing a poem or a mathematical demonstration by throwing letters at random on a table.
[Expressing his reservations about Darwin's proposed evolution of the eye by natural selection.]

That is as natural to man as thinking or throwing snowballs.

The Europeans and the Americans are not throwing $10 billion down this gigantic tube for nothing. We're exploring the very forefront of physics and cosmology with the Large Hadron Collider because we want to have a window on creation, we want to recreate a tiny piece of Genesis to unlock some of the greatest secrets of the universe.

The observer is not he who merely sees the thing which is before his eyes, but he who sees what parts the thing is composed of. To do this well is a rare talent. One person, from inattention, or attending only in the wrong place, overlooks half of what he sees; another sets down much more than he sees, confounding it with what he imagines, or with what he infers; another takes note of the kind of all the circumstances, but being inexpert in estimating their degree, leaves the quantity of each vague and uncertain; another sees indeed the whole, but makes such an awkward division of it into parts, throwing into one mass things which require to be separated, and separating others which might more conveniently be considered as one, that the result is much the same, sometimes even worse than if no analysis had been attempted at all.

There is not perhaps another object in the heavens that presents us with such a variety of extraordinary phenomena as the planet Saturn: a magnificent globe, encompassed by a stupendous double ring: attended by seven satellites: ornamented with equatorial belts: compressed at the poles: turning upon its axis: mutually eclipsing its ring and satellites, and eclipsed by them: the most distant of the rings also turning upon its axis, and the same taking place with the farthest of the satellites: all the parts of the system of Saturn occasionally reflecting light to each other: the rings and moons illuminating the nights of the Saturnian: the globe and satellites enlightening the dark parts of the rings: and the planet and rings throwing back the sun's beams upon the moons, when they are deprived of them at the time of their conjunctions. (1805)

There must be a reason why some people can afford to live well. They must have worked for it. I only feel angry when I see waste. When I see people throwing away things we could use.

Various accounts of Empedocles’ death are given in ancient sources. His enemies said that his desire to be thought a god led him to throw himself into the crater of Mount Etna so that he might vanish from the world completely and thus lead men to believe he had achieved apotheosis. Unfortunately the volcano defeated his design by throwing out one of the philosopher’s sandals.

We ought to observe that practice which is the hardest of all—especially for young physicians—we ought to throw in no medicine at all—to abstain—to observe a wise and masterly inactivity.

While reading in a textbook of chemistry, … I came across the statement, “nitric acid acts upon copper.” I was getting tired of reading such absurd stuff and I determined to see what this meant. Copper was more or less familiar to me, for copper cents were then in use. I had seen a bottle marked “nitric acid” on a table in the doctor’s office where I was then “doing time.” I did not know its peculiarities, but I was getting on and likely to learn. The spirit of adventure was upon me. Having nitric acid and copper, I had only to learn what the words “act upon” meant … I put one of them [cent] on the table, opened the bottle marked “nitric acid”; poured some of the liquid on the copper; and prepared to make an observation. But what was this wonderful thing which I beheld? The cent was already changed, and it was no small change either. A greenish blue liquid foamed and fumed over the cent and over the table. The air in the neighborhood of the performance became colored dark red. A great colored cloud arose. This was disagreeable and suffocating—how should I stop this? I tried to get rid of the objectionable mess by picking it up and throwing it out of the window, which I had meanwhile opened. I learned another fact—nitric acid not only acts upon copper but it acts upon fingers. The pain led to another unpremeditated experiment. I drew my fingers across my trousers and another fact was discovered. Nitric acid acts upon trousers. Taking everything into consideration, that was the most impressive experiment, and, relatively, probably the most costly experiment I have ever performed.

Your true inventor has a yen to invent, just as a painter or musician is impelled to create something in his art. I began wanting to invent when I was in short pants. At the age of eight—and that was forty years ago—I invented a rock-thrower. Later I found that the Romans had done a much better job some two thousand years before me.