... we ought to have saints' days to commemorate the great discoveries which have been made for all mankind, and perhaps for all time—or for whatever time may be left to us. Nature ... is a prodigal of pain. I should like to find a day when we can take a holiday, a day of jubilation when we can fête good Saint Anaesthesia and chaste and pure Saint Antiseptic. ... I should be bound to celebrate, among others, Saint Penicillin...

Bernard: Oh, you’re going to zap me with penicillin and pesticides. Spare me that and I’ll spare you the bomb and aerosols. But don’t confuse progress with perfectibility. A great poet is always timely. A great philosopher is an urgent need. There’s no rush for Isaac Newton. We were quite happy with Aristotle’s cosmos. Personally, I preferred it. Fifty-five crystal spheres geared to God’s crankshaft is my idea of a satisfying universe. I can’t think of anything more trivial than the speed of light. Quarks, quasars—big bangs, black holes—who [cares]? How did you people con us out of all that status? All that money? And why are you so pleased with yourselves?
Chloe: Are you against penicillin, Bernard?
Bernard: Don’t feed the animals.

Applied research generates improvements, not breakthroughs. Great scientific advances spring from pure research. Even scientists renowned for their “useful” applied discoveries often achieved success only when they abandoned their ostensible applied-science goal and allowed their minds to soar—as when Alexander Fleming, “just playing about,” refrained from throwing away green molds that had ruined his experiment, studied them, and discovered penicillin. Or when C. A. Clarke, a physician affiliated with the University of Liverpool, became intrigued in the 1950s by genetically created color patterns that emerged when he cross-bred butterflies as a hobby. His fascination led him—“by the pleasant route of pursuing idle curiosity”—to the successful idea for preventing the sometimes fatal anemia that threatened babies born of a positive-Rhesus-factor father and a negative-Rhesus-factor mother.

Faced with the admitted difficulty of managing the creative process, we are doubling our efforts to do so. Is this because science has failed to deliver, having given us nothing more than nuclear power, penicillin, space travel, genetic engineering, transistors, and superconductors? Or is it because governments everywhere regard as a reproach activities they cannot advantageously control? They felt that way about the marketplace for goods, but trillions of wasted dollars later, they have come to recognize the efficiency of this self-regulating system. Not so, however, with the marketplace for ideas.

I doubt that Fleming could have obtained a grant for the discovery of penicillin on that basis [a requirement for highly detailed research plans] because he could not have said, 'I propose to have an accident in a culture so that it will be spoiled by a mould falling on it, and I propose to recognize the possibility of extracting an antibiotic from this mould.'

I had fallen in love with a young man..., and we were planning to get married. And then he died of subacute bacterial endocarditis... Two years later with the advent of penicillin, he would have been saved. It reinforced in my mind the importance of scientific discovery...

If it is good to teach students about the chemical industry then why is it not good to assign ethical qualities to substances along with their physical and chemical ones? We might for instance say that CS [gas] is a bad chemical because it can only ever be used by a few people with something to protect against many people with nothing to lose. Terylene or indigotin are neutral chemicals. Under capitalism their production is an exploitive process, under socialism they are used for the common good. Penicillin is a good chemical.

In my first publication I might have claimed that I had come to the conclusion, as a result of serious study of the literature and deep thought, that valuable antibacterial substances were made by moulds and that I set out to investigate the problem. That would have been untrue and I preferred to tell the truth that penicillin started as a chance observation. My only merit is that I did not neglect the observation and that I pursued the subject as a bacteriologist. My publication in 1929 was the starting-point of the work of others who developed penicillin especially in the chemical field.

It has been demonstrated that a species of penicillium produces in culture a very powerful antibacterial substance which affects different bacteria in different degrees. Generally speaking it may be said that the least sensitive bacteria are the Gram-negative bacilli, and the most susceptible are the pyogenic cocci ... In addition to its possible use in the treatment of bacterial infections penicillin is certainly useful... for its power of inhibiting unwanted microbes in bacterial cultures so that penicillin insensitive bacteria can readily be isolated.

It is possible that in ten years’ time penicillin itself will be a back number and will be replaced by something better. It is quite certain though that to displace penicillin any newcomer will have to be very, very good.

It was astonishing that for some considerable distance around the mould growth the staphococcal colonies were undergoing lysis. What had formerly been a well-grown colony was now a faint shadow of its former self...I was sufficiently interested to pursue the subject.
[Sep 1928, the first observation of penicillin. Lysis is the dissolution or destruction of cells.]

Penicillin .. has stimulated the search for other antibiotics and may lead to further productive study of the metabolism of microorganisms and the enzymes by which they act. From such knowledge should come not only new weapons for fighting germs but better, more rational use of those we already have.

Stay in college, get the knowledge. And stay there until you’re through. If they can make penicillin out of moldy bread, they can sure make something out of you.
Advice to a young person to continue his education.

The active agent is readily filterable and the name “penicillin” has been given to filtrates of broth cultures of the mould. … It is suggested that it may be an efficient antiseptic for application to, or injection into, areas infected with penicillin-sensitive microbes.

The genius of Man in our time has gone into jet-propulsion, atom-splitting, penicillin-curing, etc. There is left none over for works of imagination; of spiritual insight or mystical enlightenment. I asked for bread and was given a tranquilizer. It is important to recognize that in our time man has not written one word, thought one thought, put two notes or two bricks together, splashed color on to canvas or concrete into space, in a manner which will be of any conceivable imaginative interest to posterity.

The greatest possibility of evil in self-medication [with penicillin] is the use of too-small doses, so that, instead of clearing up the infection, the microbes are educated to resist penicillin and a host of penicillin-fast organisms is bred out which can be passed on to other individuals and perhaps from there to others until they reach someone who gets a septicemia or a pneumonia which penicillin cannot save. In such a case the thoughtless person playing with penicillin treatment is morally responsible for the death of the man who finally succumbs to infection with the penicillin-resistant organism. I hope this evil can be averted.

The history of penicillin is one of the disgraces of medical research. Fleming published his classic paper in the British Journal of Experimental Pathology for June, 1929, but it was not until 1939 that Florey followed up the clue. An antiseptic which is almost ideal, inasmuch as it has no toxic effects, was allowed to slumber for ten years. Had it not been for the exigencies of the present war it might be slumbering still.

While working with staphylococcus variants a number of culture-plates were set aside on the laboratory bench and examined from time to time. In the examinations these plates were necessarily exposed to the air and they became contaminated with various micro-organisms. It was noticed that around a large colony of a contaminating mould the staphylococcus colonies became transparent and were obviously undergoing lysis. Subcultures of this mould were made and experiments conducted with a view to ascertaining something of the properties of the bacteriolytic substance which had evidently been formed in the mould culture and which had diffused into the surrounding medium. It was found that broth in which the mould had been grown at room temperature for one or two weeks had acquired marked inhibitory, bacteriocidal and bacteriolytic properties to many of the more common pathogenic bacteria.