... we ought to have saints' days to commemorate the great discoveries which have been made for all mankind, and perhaps for all time—or for whatever time may be left to us. Nature ... is a prodigal of pain. I should like to find a day when we can take a holiday, a day of jubilation when we can fête good Saint Anaesthesia and chaste and pure Saint Antiseptic. ... I should be bound to celebrate, among others, Saint Penicillin...

...those who sit at their work and are therefore called 'chair workers,' such as cobblers and tailors, suffer from their own particular diseases ... [T]hese workers ... suffer from general ill-health and an excessive accumulation of unwholesome humors caused by their sedentary life ... so to some extent counteract the harm done by many days of sedentary life.
On the association between chronic inactivity and poor health. Ramazzini urged that workers should at least exercise on holidays

He (Anaxagoras) is said to have been twenty years old at the time of Xerxes' crossing, and to have lived to seventy-two. Apollodorus says in his Chronicles that he was born in the seventieth Olympiad (500-497 B.C.) and died in the first year of the eighty-eighth (428/7). He began to be a philosopher at Athens in the archonship of Callias (456/5), at the age of twenty, as Demetrius Phalereus tells us in his Register of Archons, and they say he spent thirty years there. … There are different accounts given of his trial. Sotion, in his Succession of Philosophers, says that he was prosecuted by Cleon for impiety, because he maintained that the sun was a red hot mass of metal, and after that Pericles, his pupil, had made a speech in his defence, he was fined five talents and exiled. Satyrus in his Uves, on the other hand, says that the charge was brought by Thucydides in his political campaign against Pericles; and he adds that the charge was not only for the impiety but for Medism as well; and he was condemned to death in his absence. ... Finally he withdrew to Lampsacus, and there died. It is said that when the rulers of the city asked him what privilege he wished to be granted, he replied that the children should be given a holiday every year in the month in which he died. The custom is preserved to the present day. When he died the Lampsacenes buried him with full honours.

I came from Paris in the Spring of 1884, and was brought in intimate contact with him [Thomas Edison]. We experimented day and night, holidays not excepted. His existence was made up of alternate periods of work and sleep in the laboratory. He had no hobby, cared for no sport or amusement of any kind and lived in utter disregard of the most elementary rules of hygiene. There can be no doubt that, if he had not married later a woman of exceptional intelligence, who made it the one object of her life to preserve him, he would have died many years ago from consequences of sheer neglect. So great and uncontrollable was his passion for work.

If I were a medical man, I should prescribe a holiday to any patient who considered his work important.

Let us sum up the three possible explanations of the decision to drop the bomb and its timing. The first that it was a clever and highly successful move in the field of power politics, is almost certainly correct; the second, that the timing was coincidental, convicts the American government of a hardly credible tactlessness [towards the Soviet Union]; and the third, the Roman holiday theory [a spectacular event to justify the cost of the Manhattan Project], convicts them of an equally incredible irresponsibility.

My dear nephew was only in his sixth year when I came to be detached from the family circle. But this did not hinder John and I from remaining the most affectionate friends, and many a half or whole holiday he was allowed to spend with me, was dedicated to making experiments in chemistry, where generally all boxes, tops of tea-canisters, pepper-boxes, teacups, &c., served for the necessary vessels, and the sand-tub furnished the matter to be analysed. I only had to take care to exclude water, which would have produced havoc on my carpet.

The love of experiment was very strong in him [Charles Darwin], and I can remember the way he would say, “I shan't be easy till I have tried it,” as if an outside force were driving him. He enjoyed experimenting much more than work which only entailed reasoning, and when he was engaged on one of his books which required argument and the marshalling of facts, he felt experimental work to be a rest or holiday.

The pursuit of natural knowledge, the investigation of the world – mental and material – in which we live, is not a dull and spiritless affair: rather is it a voyage of adventure of the human mind, a holiday for reckless and imaginative souls.

The universe is what it is and can’t be changed by jiggery-pokery. It works by exact rules, like a machine. … Natural law never takes a holiday. The invariability of natural law is the cornerstone of science.

Those whose lives are so filled with the romance of discovery, whose years are a holiday of exploration, … their work itself is adequate reward, they have more happiness already than their share.

When autumn returns with its long anticipated holidays, and preparations are made for a scamper in some distant locality, hammer and notebook will not occupy much room in the portmanteau, and will certainly be found most entertaining company.