“The Universe repeats itself, with the possible exception of history.” Of all earthly studies history is the only one that does not repeat itself. ... Astronomy repeats itself; botany repeats itself; trigonometry repeats itself; mechanics repeats itself; compound long division repeats itself. Every sum if worked out in the same way at any time will bring out the same answer. ... A great many moderns say that history is a science; if so it occupies a solitary and splendid elevation among the sciences; it is the only science the conclusions of which are always wrong.

'It’s this accursed Science,' I cried. 'It’s the very Devil. The mediaeval priests and persecutors were right, and the Moderns are all wrong. You tamper with it—and it offers you gifts. And directly you take them it knocks you to pieces in some unexpected way.'

... every step of the upward way is strewn with wreckage of body, mind, and morals.

... I left Caen, where I was living, to go on a geologic excursion under the auspices of the School of Mines. The incidents of the travel made me forget my mathematical work. Having reached Coutances, we entered an omnibus to go to some place or other. At the moment when I put my foot on the step, the idea came to me, without anything in my former thoughts seeming to have paved the way for it, that the transformations I had used to define the Fuchsian functions were identical with those of non-Eudidean geometry. I did not verify the idea; I should not have had time, as upon taking my seat in the omnibus, I went on with a conversation already commenced, but I felt a perfect certainty. On my return to Caen, for convenience sake, I verified the result at my leisure.

...after my first feeling of revulsion had passed, I spent three of the most entertaining and instructive weeks of my life studying the fascinating molds which appeared one by one on the slowly disintegrating mass of horse-dung. Microscopic molds are both very beautiful and absorbingly interesting. The rapid growth of their spores, the way they live on each other, the manner in which the different forms come and go, is so amazing and varied that I believe a man could spend his life and not exhaust the forms or problems contained in one plate of manure.

...it would be a simple way of solving the goiter problem. And in addition to that it would be the biggest thing in a medical proposition to be carried out in the state of Michigan, and Michigan is a large place. And as I thought of the thing the more convinced I became that this oughtn't to be a personal thing, This ought to be something done by the Michigan State Medical Society as a body.
Recommending the addition of a trace of iodine to table salt.

...Outer space, once a region of spirited international competition, is also a region of international cooperation. I realized this as early as 1959, when I attended an international conference on cosmic radiation in Moscow. At this conference, there were many differing views and differing methods of attack, but the problems were common ones to all of us and a unity of basic purpose was everywhere evident. Many of the papers presented there depended in an essential way upon others which had appeared originally in as many as three or four different languages. Surely science is one of the universal human activities.

1839—The fermentation satire
THE MYSTERY OF ALCOHOLIC FERMENTATION RESOLVED
(Preliminary Report by Letter) Schwindler
I am about to develop a new theory of wine fermentation … Depending on the weight, these seeds carry fermentation to completion somewhat less than as in the beginning, which is understandable … I shall develop a new theory of wine fermentation [showing] what simple means Nature employs in creating the most amazing phenomena. I owe it to the use of an excellent microscope designed by Pistorius.
When brewer’s yeast is mixed with water the microscope reveals that the yeast dissolves into endless small balls, which are scarcely 1/800th of a line in diameter … If these small balls are placed in sugar water, it can be seen that they consist of the eggs of animals. As they expand, they burst, and from them develop small creatures that multiply with unbelievable rapidity in a most unheard of way. The form of these animals differs from all of the 600 types described up until now. They possess the shape of a Beinsdorff still (without the cooling apparatus). The head of the tube is a sort of proboscis, the inside of which is filled with fine bristles 1/2000th of a line long. Teeth and eyes are not discernible; however, a stomach, intestinal canal, anus (a rose red dot), and organs for secretion of urine are plainly discernible. From the moment they are released from the egg one can see these animals swallow the sugar from the solution and pass it to the stomach. It is digested immediately, a process recognized easily by the resultant evacuation of excrements. In a word, these infusors eat sugar, evacuate ethyl alcohol from the intestinal canal, and carbon dioxide from the urinary organs. The bladder, in the filled state, has the form of a champagne bottle; when empty, it is a small button … As soon as the animals find no more sugar present, they eat each other up, which occurs through a peculiar manipulation; everything is digested down to the eggs which pass unchanged through the intestinal canal. Finally, one again fermentable yeast, namely the seed of the animals, which remain over.

Apud me omnia fiunt Mathematicè in Natura
In my opinion, everything happens in nature in a mathematical way.

Branches or types are characterized by the plan of their structure,
Classes, by the manner in which that plan is executed, as far as ways and means are concerned,
Orders, by the degrees of complication of that structure,
Families, by their form, as far as determined by structure,
Genera, by the details of the execution in special parts, and
Species, by the relations of individuals to one another and to the world in which they live, as well as by the proportions of their parts, their ornamentation, etc.

Clarke's Second Law: The only way of discovering the limits of the possible is to venture a little way past them into the impossible.

Copernicus, who rightly did condemn
This eldest systeme, form’d a wiser scheme;
In which he leaves the Sun at Rest, and rolls
The Orb Terrestial on its proper Poles;
Which makes the Night and Day by this Career,
And by its slow and crooked Course the Year.
The famous Dane, who oft the Modern guides,
To Earth and Sun their Provinces divides:
The Earth's Rotation makes the Night and Day,
The Sun revolving through th'Eccliptic Way
Effects the various seasons of the Year,
Which in their Turn for happy Ends appear.
This Scheme or that, which pleases best, embrace,
Still we the Fountain of their Motion trace.
Kepler asserts these Wonders may be done
By the Magnetic Vertue of the Sun,
Which he, to gain his End, thinks fit to place
Full in the Center of that mighty Space,
Which does the Spheres, where Planets roll, include,
And leaves him with Attractive Force endu'd.
The Sun, thus seated, by Mechanic Laws,
The Earth, and every distant Planet draws;
By which Attraction all the Planets found
Within his reach, are turn'd in Ether round.

Den förslags-mening: att olika element förenade med ett lika antal atomer af ett eller flere andra gemensamma element … och att likheten i krystallformen bestämmes helt och hållet af antalet af atomer, och icke af elementens.
[Mitscherlich Law of Isomerism] The same number of atoms combined in the same way produces the same crystalline form, and the same crystalline form is independent of the chemical nature of the atoms, and is determined only by their number and relative position.

Der bis zur Vorrede, die ihn abweist, gelangte Leser hat das Buch für baares Geld gekauft und frägt, was ihn schadlos hält? – Meine letzte Zuflucht ist jetzt, ihn zu erinnern, daß er ein Buch, auch ohne es gerade zu lesen, doch auf mancherlei Art zu benutzen weiß. Es kann, so gut wie viele andere, eine Lücke seiner Bibliothek ausfüllen, wo es sich, sauber gebunden, gewiß gut ausnehmen wird. Oder auch er kann es seiner gelehrten Freundin auf die Toilette, oder den Theetisch legen. Oder endlich er kann ja, was gewiß das Beste von Allem ist und ich besonders rathe, es recensiren.
The reader who has got as far as the preface and is put off by that, has paid money for the book, and wants to know how he is to be compensated. My last refuge now is to remind him that he knows of various ways of using a book without precisely reading it. It can, like many another, fill a gap in his library, where, neatly bound, it is sure to look well. Or he can lay it on the dressing-table or tea-table of his learned lady friend. Or finally he can review it; this is assuredly the best course of all, and the one I specially advise.

Die Wissenschaft ist ein Land, welches die Eigenschaft hat, um so mehr Menschen beherbergen zu können, je mehr Bewohner sich darin sammeln; sie ist ein Schatz, der um so grösser wird, je mehr man ihn teilt. Darum kann jeder von uns in seiner Art seine Arbeit tun, und die Gemeinsamkeit bedeutet nicht Gleichförmigkeit.
Science is one land, having the ability to accommodate even more people, as more residents gather in it; it is a treasure that is the greater the more it is shared. Because of that, each of us can do his work in his own way, and the common ground does not mean conformity.

Qu'une goutee de vin tombe dans un verre d'eau; quelle que soit la loi du movement interne du liquide, nous verrons bientôt se colorer d'une teinte rose uniforme et à partir de ce moment on aura beau agiter le vase, le vin et l'eau ne partaîtront plus pouvoir se séparer. Tout cela, Maxwell et Boltzmann l'ont expliqué, mais celui qui l'a vu plus nettement, dans un livre trop peu lu parce qu'il est difficile à lire, c'est Gibbs dans ses principes de la Mécanique Statistique.
Let a drop of wine fall into a glass of water; whatever be the law that governs the internal movement of the liquid, we will soon see it tint itself uniformly pink and from th at moment on, however we may agitate the vessel, it appears that the wine and water can separate no more. All this, Maxwell and Boltzmann have explained, but the one who saw it in the cleanest way, in a book that is too little read because it is difficult to read, is Gibbs, in his Principles of Statistical Mechanics.

Replying to G. H. Hardy’s suggestion that the number of a taxi (1729) was “dull”: No, it is a very interesting number; it is the smallest number expressible as a sum of two cubes in two different ways, the two ways being 1³ + 12³ and 9³ + 10³.

There is no such thing as a Scientific Mind. Scientists are people of very dissimilar temperaments doing different things in very different ways. Among scientists are collectors, classifiers, and compulsive tidiers-up; many are detectives by temperament and many are explorers; some are artists and others artisans. There are poet-scientists and philosopher-scientists and even a few mystics.

Truth then seems to me, in the proper import of the Word, to signifie nothing but the joining or separating of Signs, as the Things signified by them do agree or disagree one with another; which way of joining or separating of Signs, we call Proposition. So that Truth properly belongs only to Propositions: whereof there are two sorts, viz. Mental and Verbal; as there are two sorts of Signs commonly made use of, viz. Ideas and Words.

[About reading Rachel Carson's Silent Spring, age 14, in the back seat of his parents' sedan. I almost threw up. I got physically ill when I learned that ospreys and peregrine falcons weren't raising chicks because of what people were spraying on bugs at their farms and lawns. This was the first time I learned that humans could impact the environment with chemicals. [That a corporation would create a product that didn't operate as advertised] was shocking in a way we weren't inured to.

… the really fundamental things have a way of appearing to be simple once they have been stated by a genius. ...

SCIENCE: a way of finding things out and then making them work. Science explains what is happening around us the whole time. So does RELIGION, but science is better because it comes up with more understandable excuses when it’s wrong.

A Beethoven string-quartet is truly, as some one has said, a scraping of horses’ tails on cats’ bowels, and may be exhaustively described in such terms; but the application of this description in no way precludes the simultaneous applicability of an entirely different description.

A casual glance at crystals may lead to the idea that they were pure sports of nature, but this is simply an elegant way of declaring one’s ignorance. With a thoughtful examination of them, we discover laws of arrangement. With the help of these, calculation portrays and links up the observed results. How variable and at the same time how precise and regular are these laws! How simple they are ordinarily, without losing anything of their significance! The theory which has served to develop these laws is based entirely on a fact, whose existence has hitherto been vaguely discerned rather than demonstrated. This fact is that in all minerals which belong to the same species, these little solids, which are the crystal elements and which I call their integrant molecules, have an invariable form, in which the faces lie in the direction of the natural fracture surfaces corresponding to the mechanical division of the crystals. Their angles and dimensions are derived from calculations combined with observation.

A century ago, Darwin and his friends were thought to be dangerous atheists, but their heresy simply replaced a benevolent personal deity called God by a benevolent impersonal deity called Evolution. In their different ways Bishop Wilberforce and T.H. Huxley both believed in Fate.

A chess problem is genuine mathematics, but it is in some way “trivial” mathematics. However, ingenious and intricate, however original and surprising the moves, there is something essential lacking. Chess problems are unimportant. The best mathematics is serious as well as beautiful—“important” if you like, but the word is very ambiguous, and “serious” expresses what I mean much better.

A conflict arises when a religious community insists on the absolute truthfulness of all statements recorded in the Bible. This means an intervention on the part of religion into the sphere of science; this is where the struggle of the Church against the doctrines of Galileo and Darwin belongs. On the other hand, representatives of science have often made an attempt to arrive at fundamental judgments with respect to values and ends on the basis of scientific method, and in this way have set themselves in opposition to religion. These conflicts have all sprung from fatal errors.

A Dr van’t Hoff of the veterinary college at Utrecht, appears to have no taste for exact chemical investigation. He finds it a less arduous task to mount Pegasus (evidently borrowed from the veterinary school) and to proclaim in his La Chemie dans l’espace how, during his bold fight to the top of the chemical Parnassus, the atoms appeared to him to have grouped themselves together throughout universal space. … I should have taken no notice of this matter had not Wislicenus oddly enough written a preface to the pamphlet, and not by way of a joke but in all seriousness recommended it a worthwhile performance.

A fair number of people who go on to major in astronomy have decided on it certainly by the time they leave junior high, if not during junior high. I think it’s somewhat unusual that way. I think most children pick their field quite a bit later, but astronomy seems to catch early, and if it does, it sticks.

A good deal of my research in physics has consisted in not setting out to solve some particular problem, but simply examining mathematical quantities of a kind that physicists use and trying to fit them together in an interesting way, regardless of any application that the work may have. It is simply a search for pretty mathematics. It may turn out later to have an application. Then one has good luck. At age 78.

A grove of giant redwoods or sequoias should be kept just as we keep a great or beautiful cathedral. The extermination of the passenger pigeon meant that mankind was just so much poorer; exactly as in the case of the destruction of the cathedral at Rheims. And to lose the chance to see frigate-birds soaring in circles above the storm, or a file of pelicans winging their way homeward across the crimson afterglow of the sunset, or a myriad terns flashing in the bright light of midday as they hover in a shifting maze above the beach—why, the loss is like the loss of a gallery of the masterpieces of the artists of old time.

A hen is only an egg's way of making another egg.

A historical fact is rather like the flamingo that Alice in Wonderland tried to use as a croquet mallet. As soon as she got its neck nicely straightened out and was ready to hit the ball, it would turn and look at her with a puzzled expression, and any biographer knows that what is called a “fact” has a way of doing the same.

A hundred years ago the study of life was often pursued, and also presented to the public, in a highly unified way. Darwin, as everyone knows, in addressing the world at large began his story with the history of pigeons and ended it with the breeding of primroses, having made excursions on the way into the origins of coral reefs and of the races of Man.

A hundred years ago … an engineer, Herbert Spencer, was willing to expound every aspect of life, with an effect on his admiring readers which has not worn off today.
Things do not happen quite in this way nowadays. This, we are told, is an age of specialists. The pursuit of knowledge has become a profession. The time when a man could master several sciences is past. He must now, they say, put all his efforts into one subject. And presumably, he must get all his ideas from this one subject. The world, to be sure, needs men who will follow such a rule with enthusiasm. It needs the greatest numbers of the ablest technicians. But apart from them it also needs men who will converse and think and even work in more than one science and know how to combine or connect them. Such men, I believe, are still to be found today. They are still as glad to exchange ideas as they have been in the past. But we cannot say that our way of life is well-fitted to help them. Why is this?

A line is not made up of points. … In the same way, time is not made up of parts considered as indivisible “nows.”
Part of Aristotle’s reply to Zeno's paradox concerning continuity.

A man loses his fortune; he gains earnestness. His eyesight goes; it leads him to a spirituality... We think we are pushing our own way bravely, but there is a great Hand in ours all the time.

A mathematical proof should resemble a simple and clear-cut constellation, not a scattered cluster in the Milky Way.

A mathematical science is any body of propositions which is capable of an abstract formulation and arrangement in such a way that every proposition of the set after a certain one is a formal logical consequence of some or all the preceding propositions. Mathematics consists of all such mathematical sciences.

A mathematician’s work is mostly a tangle of guesswork, analogy, wishful thinking and frustration, and proof, far from being the core of discovery, is more often than not a way of making sure that our minds are not playing tricks.

A mere inference or theory must give way to a truth revealed; but a scientific truth must be maintained, however contradictory it may appear to the most cherished doctrines of religion.

A mind which has once imbibed a taste for scientific enquiry, and has learnt the habit of applying its principles readily to the cases which occur, has within itself an inexhaustable source of pure and exciting contemplations:— One would think that Shakespeare had such a mind in view when he describes a contemplative man as finding
    “Tongues in trees—books in running brooks—
    Sermons in stones—and good in everything.”
Accustomed to trace the operations of general causes and the exemplification of general laws, in circumstances where the uninformed and uninquiring eye, perceives neither novelty nor beauty, he walks in the midst of wonders; every object which falls in his way elucidates some principle, affords some instruction and impresses him with a sense of harmony and order. Nor is it a mere passive pleasure which is thus communicated. A thousand questions are continually arising in his mind, a thousand objects of enquiry presenting themselves, which keep his faculties in constant exercise, and his thoughts perpetually on the wing, so that lassitude is excluded from his life, and that craving after artificial excitement and dissipation of the mind, which leads so many into frivolous, unworthy, and destructive pursuits, is altogether eradicated from his bosom.

A neurotic person can be most simply described as someone who, while he was growing up, learned ways of behaving that are self-defeating in his society.

A plain, reasonable working man supposes, in the old way which is also the common-sense way, that if there are people who spend their lives in study, whom he feeds and keeps while they think for him—then no doubt these men are engaged in studying things men need to know; and he expects of science that it will solve for him the questions on which his welfare, and that of all men, depends. He expects science to tell him how he ought to live: how to treat his family, his neighbours and the men of other tribes, how to restrain his passions, what to believe in and what not to believe in, and much else. And what does our science say to him on these matters?
It triumphantly tells him: how many million miles it is from the earth to the sun; at what rate light travels through space; how many million vibrations of ether per second are caused by light, and how many vibrations of air by sound; it tells of the chemical components of the Milky Way, of a new element—helium—of micro-organisms and their excrements, of the points on the hand at which electricity collects, of X rays, and similar things.
“But I don't want any of those things,” says a plain and reasonable man—“I want to know how to live.”

A research laboratory jealous of its reputation has to develop less formal, more intimate ways of forming a corporate judgment of the work its people do. The best laboratories in university departments are well known for their searching, mutual questioning.

A science or an art may be said to be “useful” if its development increases, even indirectly, the material well-being and comfort of men, it promotes happiness, using that word in a crude and commonplace way.

A scientist can be productive in various ways. One is having the ability to plan and carry out experiments, but the other is having the ability to formulate new ideas, which can be about what experiments can be carried out … by making [the] proper calculations. Individual scientists who are successful in their work are successful for different reasons.

A scientist is in a sense a learned small boy. There is something of the scientist in every small boy. Others must outgrow it. Scientists can stay that way all their lives.

A scientist should be the happiest of men. Not that science isn't serious; but as everyone knows, being serious is one way of being happy, just as being gay is one way of being unhappy.

A short, broad man of tremendous vitality, the physical type of Hereward, the last of the English, and his brother-in-arms, Winter, Sylvester’s capacious head was ever lost in the highest cloud-lands of pure mathematics. Often in the dead of night he would get his favorite pupil, that he might communicate the very last product of his creative thought. Everything he saw suggested to him something new in the higher algebra. This transmutation of everything into new mathematics was a revelation to those who knew him intimately. They began to do it themselves. His ease and fertility of invention proved a constant encouragement, while his contempt for provincial stupidities, such as the American hieroglyphics for π and e, which have even found their way into Webster’s Dictionary, made each young worker apply to himself the strictest tests.

A single kind of red cell is supposed to have an enormous number of different substances on it, and in the same way there are substances in the serum to react with many different animal cells. In addition, the substances which match each kind of cell are different in each kind of serum. The number of hypothetical different substances postulated makes this conception so uneconomical that the question must be asked whether it is the only one possible. ... We ourselves hold that another, simpler, explanation is possible.

A single tree by itself is dependent upon all the adverse chances of shifting circumstances. The wind stunts it: the variations in temperature check its foliage: the rains denude its soil: its leaves are blown away and are lost for the purpose of fertilisation. You may obtain individual specimens of line trees either in exceptional circumstances, or where human cultivation had intervened. But in nature the normal way in which trees flourish is by their association in a forest. Each tree may lose something of its individual perfection of growth, but they mutually assist each other in preserving the conditions of survival. The soil is preserved and shaded; and the microbes necessary for its fertility are neither scorched, nor frozen, nor washed away. A forest is the triumph of the organisation of mutually dependent species.

A small cabin stands in the Glacier Peak Wilderness, about a hundred yards off a trail that crosses the Cascade Range. In midsummer, the cabin looked strange in the forest. It was only twelve feet square, but it rose fully two stories and then had a high and steeply peaked roof. From the ridge of the roof, moreover, a ten-foot pole stuck straight up. Tied to the top of the pole was a shovel. To hikers shedding their backpacks at the door of the cabin on a cold summer evening—as the five of us did—it was somewhat unnerving to look up and think of people walking around in snow perhaps thirty-five feet above, hunting for that shovel, then digging their way down to the threshold.

A social fact is every way of acting, fixed or not, capable of exercising on the individual an external constraint; or again, every way of acting which is general throughout a given society, while at the same time existing in its own right independent of its individual manifestations.

A zygote is a gamete’s way of producing more gametes. This may be the purpose of the universe.

According to the older view, for every single effect of a serum, there was a separate substance, or at least a particular chemical group... A normal serum contained as many different haemagglutinins as it agglutinated different cells. The situation was undoubtedly made much simpler if, to use the Ehrlich terminology... the separate haptophore groups can combine with an extremely large number of receptors in stepwise differing quantities as a stain does with different animal tissues, though not always with the same intensity. A normal serum would therefore visibly affect such a large number of different blood cells... not because it contained countless special substances, but because of the colloids of the serum, and therefore of the agglutinins by reason of their chemical constitution and the electrochemical properties resulting from it. That this manner of representation is a considerable simplification is clear; it also opens the way to direct experimental testing by the methods of structural chemistry.

Accordingly the primordial state of things which I picture is an even distribution of protons and electrons, extremely diffuse and filling all (spherical) space, remaining nearly balanced for an exceedingly long time until its inherent instability prevails. We shall see later that the density of this distribution can be calculated; it was about one proton and electron per litre. There is no hurry for anything to begin to happen. But at last small irregular tendencies accumulate, and evolution gets under way. The first stage is the formation of condensations ultimately to become the galaxies; this, as we have seen, started off an expansion, which then automatically increased in speed until it is now manifested to us in the recession of the spiral nebulae.
As the matter drew closer together in the condensations, the various evolutionary processes followed—evolution of stars, evolution of the more complex elements, evolution of planets and life.

Act as if you are going to live for ever and cast your plans way ahead. You must feel responsible without time limitations, and the consideration of whether you may or may not be around to see the results should never enter your thoughts.

After what has been premised, I think we may lay down the following Conclusions. First, It is plain Philosophers amuse themselves in vain, when they inquire for any natural efficient Cause, distinct from a Mind or Spirit. Secondly, Considering the whole Creation is the Workmanship of a wise and good Agent, it should seem to become Philosophers, to employ their Thoughts (contrary to what some hold) about the final Causes of Things: And I must confess, I see no reason, why pointing out the various Ends, to which natural Things are adapted and for which they were originally with unspeakable Wisdom contrived, should not be thought one good way of accounting for them, and altogether worthy a Philosopher.

All animals whatsoever, whether they fly or swim or walk upon dry land, whether they bring forth their young alive or in the egg, develop in the same way.

All appearances to the contrary, the only watchmaker in nature is the blind forces of physics, albeit deployed in very special way. A true watchmaker has foresight: he designs his cogs springs, and plans their interconnections, with a future purpose in his mind's eye. Natural selection, the blind, unconscious, automatic process which Darwin discovered, and which we now know is the explanation for the existence and apparently purposeful form of all life, has no purpose in mind. It has no mind and no mind's eye. It does not plan for the future. It has no vision, no foresight, no sight at all. If it can be said to play the role of watchmaker in nature, it is the blind watchmaker.

All life is linked together in such a way that no part of the chain is unimportant. Frequently, upon the action of some of these minute beings depends the material success or failure of a great commonwealth.

All men seek to be enlightened. Religion is but the most ancient and honorable way in which men have striven to make sense out of God's universe. Scientists seek the lawfulness of events. It is the task of Religion to fit man into this lawfulness.

All men seek to be enlightened. Religion is but the most ancient and honorable way in which men have striven to make sense out of God's universe. Scientists seek the lawfulness of events. It is the task of Religion to fit man into this lawfulness.

All men seek to be enlightened. Religion is but the most ancient and honorable way in which men have striven to make sense out of God's universe. Scientists seek the lawfulness of events. It is the task of Religion to fit man into this lawfulness.

All power, all subordination rests on the executioner: he is the horror and the bond of human association. Remove this incomprehensible agent from the world, and the very moment order gives way to chaos, thrones topple, and society disappears

All that Anatomie can doe is only to shew us the gross and sensible parts of the body, or the vapid and dead juices all which, after the most diligent search, will be noe more able to direct a physician how to cure a disease than how to make a man; for to remedy the defects of a part whose organicall constitution and that texture whereby it operates, he cannot possibly know, is alike hard, as to make a part which he knows not how is made. Now it is certaine and beyond controversy that nature performs all her operations on the body by parts so minute and insensible that I thinke noe body will ever hope or pretend, even by the assistance of glasses or any other intervention, to come to a sight of them, and to tell us what organicall texture or what kinde offerment (for whether it be done by one or both of these ways is yet a question and like to be soe always notwithstanding all the endeavours of the most accurate dissections) separate any part of the juices in any of the viscera, or tell us of what liquors the particles of these juices are, or if this could be donne (which it is never like to be) would it at all contribute to the cure of the diseases of those very parts which we so perfectly knew.

All that can be said upon the number and nature of elements is, in my opinion, confined to discussions entirely of a metaphysical nature. The subject only furnishes us with indefinite problems, which may be solved in a thousand different ways, not one of which, in all probability, is consistent with nature. I shall therefore only add upon this subject, that if, by the term elements, we mean to express those simple and indivisible atoms of which matter is composed, it is extremely probable we know nothing at all about them; but, if we apply the term elements, or principles of bodies, to express our idea of the last point which analysis is capable of reaching, we must admit, as elements, all the substances into which we are capable, by any means, to reduce bodies by decomposition.

All that Eddington and Millikan achieve, when they attempt their preposterous reconciliation of science and theology, is to prove that they themselves, for all their technical skill, are scientists only by trade, not by conviction. They practice science diligently and to some effect, but only in the insensate way in which Blind Tom played the piano. … they can’t get rid of a congenital incredulity. Science, to them, remains a bit strange and shocking. They are somewhat in the position of a Christian clergyman who finds himself unable to purge himself of a suspicion that Jonah, after all, probably did not swallow the whale.

All the old constellations had gone from the sky, however: that slow movement which is imperceptible in a hundred human lifetimes, had long since rearranged them in unfamiliar groupings. But the Milky Way, it seemed to me, was still the same tattered streamer of star-dust as of yore.

All the properties that we designate as activity of the soul, are only the functions of the cerebral substance, and to express ourselves in a coarser way, thought is just about to the brain what bile is to the liver and urine to the kidney. It is absurd to admit an independent soul who uses the cerebellum as an instrument with which he would work as he pleases.

All your names I and my friend approve of or nearly all as to sense & expression, but I am frightened by their length & sound when compounded. As you will see I have taken deoxide and skaiode because they agree best with my natural standard East and West. I like Anode & Cathode better as to sound, but all to whom I have shewn them have supposed at first that by Anode I meant No way.

Almost everything, which the mathematics of our century has brought forth in the way of original scientific ideas, attaches to the name of Gauss.

Alphonse of Castile is reported to have said that if he had had the making of the universe he would have done it much better. And I think so too. Instead of making a man go through the degradation of faculties and death, he should continually improve with age, and then be translated from this world to a superior planet, where he should begin life with the knowledge gained here, and so on. That would be to my mind, as an old man, a more satisfactory way of conducting affairs

Although such research [into the paranormal] has yet to produce anything in the way of a repeatable controlled experiment, its practitioners argue that its revolutionary potentialities justify its continuation. My own feeling is that after a century of total failure it has become a bloody bore.

Although the way ahead [for immunology] is full of pitfalls and difficulties, this is indeed an exhilarating prospect. There is no danger of a shortage of forthcoming excitement in the subject. Yet, as always, the highlights of tomorrow are the unpredictabilities of today.

Although we know nothing of what an atom is, yet we cannot resist forming some idea of a small particle, which represents it to the mind ... there is an immensity of facts which justify us in believing that the atoms of matter are in some way endowed or associated with electrical powers, to which they owe their most striking qualities, and amongst them their mutual chemical affinity.
[Summarizing his investigations in electrolysis.]

Alvarez seemed to care less about the way the picture in the puzzle would look, when everything fit together, than about the fun of looking for pieces that fit. He loved nothing more than doing something that everybody else thought impossible. His designs were clever, and usually exploited some little-known principle that everyone else had forgotten.

Among the multitude of animals which scamper, fly, burrow and swim around us, man is the only one who is not locked into his environment. His imagination, his reason, his emotional subtlety and toughness, make it possible for him not to accept the environment, but to change it. And that series of inventions, by which man from age to age has remade his environment, is a different kind of evolution—not biological, but cultural evolution. I call that brilliant sequence of cultural peaks The Ascent of Man. I use the word ascent with a precise meaning. Man is distinguished from other animals by his imaginative gifts. He makes plans, inventions, new discoveries, by putting different talents together; and his discoveries become more subtle and penetrating, as he learns to combine his talents in more complex and intimate ways. So the great discoveries of different ages and different cultures, in technique, in science, in the arts, express in their progression a richer and more intricate conjunction of human faculties, an ascending trellis of his gifts.

An atom-blaster is a good weapon, but it can point both ways.

An evolutionary perspective of our place in the history of the earth reminds us that Homo sapiens sapiens has occupied the planet for the tiniest fraction of that planet's four and a half thousand million years of existence. In many ways we are a biological accident, the product of countless propitious circumstances. As we peer back through the fossil record, through layer upon layer of long-extinct species, many of which thrived far longer than the human species is ever likely to do, we are reminded of our mortality as a species. There is no law that declares the human animal to be different, as seen in this broad biological perspective, from any other animal. There is no law that declares the human species to be immortal.

An example of such emergent phenomena is the origin of life from non-living chemical compounds in the oldest, lifeless oceans of the earth. Here, aided by the radiation energy received from the sun, countless chemical materials were synthesized and accumulated in such a way that they constituted, as it were, a primeval “soup.” In this primeval soup, by infinite variations of lifeless growth and decay of substances during some billions of years, the way of life was ultimately reached, with its metabolism characterized by selective assimilation and dissimilation as end stations of a sluiced and canalized flow of free chemical energy.

An experiment is never a failure solely because it fails to achieve predicted results. An experiment is a failure only when it also fails adequately to test the hypothesis in question, when the data it produces don’t prove anything one way or another.

An important scientific innovation rarely makes its way by gradually winning over and converting its opponents. What does happen is that its opponents gradually die out, and that the growing generation is familiarized with the ideas from the beginning.

An incidental remark from a German colleague illustrates the difference between Prussian ways and our own. He had apparently been studying the progress of our various crews on the river, and had been struck with the fact that though the masters in charge of the boats seemed to say and do very little, yet the boats went continually faster and faster, and when I mentioned Dr. Young’s book to him, he made the unexpected but suggestive reply: “Mathematics in Prussia! Ah, sir, they teach mathematics in Prussia as you teach your boys rowing in England: they are trained by men who have been trained by men who have themselves been trained for generations back.”

An unelectrified atom is so elusive that unless more than a million million are present we have no means sufficiently sensitive to detect them, or, to put it another way, unless we had a better test for a man than for an unelectrified molecule, we should be unable to find out that the earth was inhabited. … A billion unelectrified atoms may escape our observation, whereas a dozen or so electrified ones are detected without difficulty.

And from this such small difference of eight minutes [of arc] it is clear why Ptolemy, since he was working with bisection [of the linear eccentricity], accepted a fixed equant point… . For Ptolemy set out that he actually did not get below ten minutes [of arc], that is a sixth of a degree, in making observations. To us, on whom Divine benevolence has bestowed the most diligent of observers, Tycho Brahe, from whose observations this eight-minute error of Ptolemy’s in regard to Mars is deduced, it is fitting that we accept with grateful minds this gift from God, and both acknowledge and build upon it. So let us work upon it so as to at last track down the real form of celestial motions (these arguments giving support to our belief that the assumptions are incorrect). This is the path I shall, in my own way, strike out in what follows. For if I thought the eight minutes in [ecliptic] longitude were unimportant, I could make a sufficient correction (by bisecting the [linear] eccentricity) to the hypothesis found in Chapter 16. Now, because they could not be disregarded, these eight minutes alone will lead us along a path to the reform of the whole of Astronomy, and they are the matter for a great part of this work.

And I believe there are many Species in Nature, which were never yet taken notice of by Man, and consequently of no use to him, which yet we are not to think were created in vain; but it’s likely … to partake of the overflowing Goodness of the Creator, and enjoy their own Beings. But though in this sense it be not true, that all things were made for Man; yet thus far it is, that all the Creatures in the World may be some way or other useful to us, at least to exercise our Wits and Understandings, in considering and contemplating of them, and so afford us Subject of Admiring and Glorifying their and our Maker. Seeing them, we do believe and assert that all things were in some sense made for us, we are thereby obliged to make use of them for those purposes for which they serve us, else we frustrate this End of their Creation.

And if you want the exact moment in time, it was conceived mentally on 8th March in this year one thousand six hundred and eighteen, but submitted to calculation in an unlucky way, and therefore rejected as false, and finally returning on the 15th of May and adopting a new line of attack, stormed the darkness of my mind. So strong was the support from the combination of my labour of seventeen years on the observations of Brahe and the present study, which conspired together, that at first I believed I was dreaming, and assuming my conclusion among my basic premises. But it is absolutely certain and exact that the proportion between the periodic times of any two planets is precisely the sesquialterate proportion of their mean distances.

And men ought to know that from nothing else but thence [from the brain] come joys, delights, laughter and sports, and sorrows, griefs, despondency, and lamentations. And by this, in an especial manner, we acquire wisdom and knowledge, and see and hear, and know what are foul and hat are fair, what are bad and what are good, what are sweet, and what unsavory... And by the same organ we become mad and delirious, and fears and terrors assail us... All these things we endure from the brain, when it is not healthy... In these ways I am of the opinion that the brain exercises the greatest power in the man. This is the interpreter to us of those things which emanate from the air, when it [the brain] happens to be in a sound state.

And so I conclude that blood lives and is nourished of itself and in no way depends on any other part of the body as being prior to it or more excellent... So that from this we may perceive the causes not only of life in general... but also of longer or shorter life, of sleeping and waking, of skill, of strength and so forth.

And the Social Science … a dreary, desolate, and indeed quite abject and distressing one; what we might call, by way of eminence, the dismal science.

And yet in a funny way our lack of success led to our breakthrough; because, since we could not get a cell line off the shelf doing what we wanted, we were forced to construct it. And the original experiment ... developed into a method for the production of hybridomas ... [which] was of more importance than our original purpose.

Another argument of hope may be drawn from this–that some of the inventions already known are such as before they were discovered it could hardly have entered any man's head to think of; they would have been simply set aside as impossible. For in conjecturing what may be men set before them the example of what has been, and divine of the new with an imagination preoccupied and colored by the old; which way of forming opinions is very fallacious, for streams that are drawn from the springheads of nature do not always run in the old channels.

Another diversity of Methods is according to the subject or matter which is handled; for there is a great difference in delivery of the Mathematics, which are the most abstracted of knowledges, and Policy, which is the most immersed ... , yet we see how that opinion, besides the weakness of it, hath been of ill desert towards learning, as that which taketh the way to reduce learning to certain empty and barren generalities; being but the very husks and shells of sciences, all the kernel being forced out and expulsed with the torture and press of the method.

Any child born into the hugely consumptionist way of life so common in the industrial world will have an impact that is, on average, many times more destructive than that of a child born in the developing world.

Any increase in knowledge anywhere helps pave the way for an increase in knowledge everywhere.

Any opinion as to the form in which the energy of gravitation exists in space is of great importance, and whoever can make his opinion probable will have, made an enormous stride in physical speculation. The apparent universality of gravitation, and the equality of its effects on matter of all kinds are most remarkable facts, hitherto without exception; but they are purely experimental facts, liable to be corrected by a single observed exception. We cannot conceive of matter with negative inertia or mass; but we see no way of accounting for the proportionality of gravitation to mass by any legitimate method of demonstration. If we can see the tails of comets fly off in the direction opposed to the sun with an accelerated velocity, and if we believe these tails to be matter and not optical illusions or mere tracks of vibrating disturbance, then we must admit a force in that direction, and we may establish that it is caused by the sun if it always depends upon his position and distance.

Any work of science, no matter what its point of departure, cannot become fully convincing until it crosses the boundary between the theoretical and the experimental: Experimentation must give way to argument, and argument must have recourse to experimentation.

Anyone of common mental and physical health can practice scientific research. … Anyone can try by patient experiment what happens if this or that substance be mixed in this or that proportion with some other under this or that condition. Anyone can vary the experiment in any number of ways. He that hits in this fashion on something novel and of use will have fame. … The fame will be the product of luck and industry. It will not be the product of special talent.

Anything worth doing is worth doing twice, the first time quick and dirty and the second time the best way you can.

Are we using science in ways that it wasn't intended to, in which case we should be a little careful, or are we using faith in ways that faith wasn't really designed for? There are certain questions that are better answered by one approach than the other, and if you start mixing that up, then you end up in … conflict.

Art and science coincide insofar as both aim to improve the lives of men and women. The latter normally concerns itself with profit, the former with pleasure. In the coming age, art will fashion our entertainment out of new means of productivity in ways that will simultaneously enhance our profit and maximize our pleasure.

Art and science work in quite different ways: agreed. But, bad as it may sound, I have to admit that I cannot get along as an artist without the use of one or two sciences. ... In my view, the great and complicated things that go on in the world cannot be adequately recognized by people who do not use every possible aid to understanding.

Art is the beautiful way of doing things. Science is the effective way of doing things. Business is the economic way of doing things.

As crude a weapon as the cave man’s club, the chemical barrage has been hurled against the fabric of life—a fabric on the one hand delicate and destructible, on the other miraculously tough and resilient, and capable of striking back in unexpected ways. [On the effect of chemical insecticides and fertilizers.]

As for your doctrines I am prepared to go to the Stake if requisite ... I trust you will not allow yourself to be in any way disgusted or annoyed by the considerable abuse & misrepresentation which unless I greatly mistake is in store for you... And as to the curs which will bark and yelp - you must recollect that some of your friends at any rate are endowed with an amount of combativeness which (though you have often & justly rebuked it) may stand you in good stead - I am sharpening up my claws and beak in readiness.

As for “Don’t be evil,” we have tried to define precisely what it means to be a force for good—always do the right, ethical thing. Ultimately, “Don’t be evil” seems the easiest way to summarize it.

As geology is essentially a historical science, the working method of the geologist resembles that of the historian. This makes the personality of the geologist of essential importance in the way he analyzes the past.

As he [Clifford] spoke he appeared not to be working out a question, but simply telling what he saw. Without any diagram or symbolic aid he described the geometrical conditions on which the solution depended, and they seemed to stand out visibly in space. There were no longer consequences to be deduced, but real and evident facts which only required to be seen. … So whole and complete was his vision that for the time the only strange thing was that anybody should fail to see it in the same way. When one endeavored to call it up again, and not till then, it became clear that the magic of genius had been at work, and that the common sight had been raised to that higher perception by the power that makes and transforms ideas, the conquering and masterful quality of the human mind which Goethe called in one word das Dämonische.

As I have already mentioned, wherever cells are formed, this tough fluid precedes the first solid structures that indicate the presence of future cells. Moreover, we must assume that this substance furnishes the material for the formation of the nucleus and of the primitive sac, not only because these structures are closely apposed to it, but also because,they react to iodine in the same way. We must assume also that the organization of this substance is the process that inaugurates the formation of new cells. It therefore seems justifiable for me to propose a name that refers to its physiological function: I propose the word protoplasma.

As never before, the work of the engineer is basic to the kind of society to which our best efforts are committed. Whether it be city planning, improved health care in modern facilities, safer and more efficient transportation, new techniques of communication, or better ways to control pollution and dispose of wastes, the role of the engineer—his initiative, creative ability, and hard work—is at the root of social progress.

As plants convert the minerals into food for animals, so each man converts some raw material in nature to human use. The inventors of fire, electricity, magnetism, iron, lead, glass, linen, silk, cotton; the makers of tools; the inventor of decimal notation, the geometer, the engineer, the musician, severally make an easy way for all, through unknown and impossible confusions.

As regards railways, it is certain that nothing is so profitable, because nothing is so cheaply transported, as passenger traffic. Goods traffic, of whatsoever description, must be more or less costly. Every article conveyed by railway requires handling and conveyance beyond the limit of the railway stations; but passengers take care of themselves, and find their own way.

As science has supplanted its predecessors, so it may hereafter be superseded by some more perfect hypothesis, perhaps by some totally different way of looking at the phenomena—of registering the shadows on the screen—of which we in this generation can form no idea. The advance of knowledge is an infinite progression towards a goal that for ever recedes.

As to giving credit to whom credit is due, rest assured the best way to do good to one’s-self is to do justice to others. There is plenty for everybody in science, and more than can be consumed in our time. One may get a fair name by suppressing references, but the Jewish maxim is true, “He who seeks a name loses fame.”

As we push ever more deeply into the universe, probing its secrets, discovering its way, we must also constantly try to learn to cooperate across the frontiers that really divide earth’s surface.

As, pricked out with less and greater lights, between the poles of the universe, the Milky Way so gleameth white as to set very sages questioning.

Astrology fosters astronomy. Mankind plays its way up.

Astronomers and physicists, dealing habitually with objects and quantities far beyond the reach of the senses, even with the aid of the most powerful aids that ingenuity has been able to devise, tend almost inevitably to fall into the ways of thinking of men dealing with objects and quantities that do not exist at all, e.g., theologians and metaphysicians. Thus their speculations tend almost inevitably to depart from the field of true science, which is that of precise observation, and to become mere soaring in the empyrean. The process works backward, too. That is to say, their reports of what they pretend actually to see are often very unreliable. It is thus no wonder that, of all men of science, they are the most given to flirting with theology. Nor is it remarkable that, in the popular belief, most astronomers end by losing their minds.

At fertilization, these two “haploid” nuclei are added together to make a “diploid” nucleus that now contains 2a, 2b and so on; and, by the splitting of each chromosome and the regulated karyokinetic separation of the daughter chromosomes, this double series is inherited by both of the primary blastomeres. In the resulting resting nuclei the individual chromosomes are apparently destroyed. But we have the strongest of indications that, in the stroma of the resting nucleus, every one of the chromosomes that enters the nucleus survives as a well-defined region; and as the cell prepares for its next division this region again gives rise to the same chromosome (Theory of the Individuality of the Chromosomes). In this way the two sets of chromosomes brought together at fertilization are inherited by all the cells of the new individual. It is only in the germinal cells that the so called reduction division converts the double series into a single one. Out of the diploid state, the haploid is once again generated.

At last gleams of light have come, and I am almost convinced (quite contrary to opinion I started with) that species are not (it is like confessing a murder) immutable. Heaven forfend me from Lamarck nonsense of a “tendency to progression”, “adaptations from the slow willing of animals”, &c! But the conclusions I am led to are not widely different from his; though the means of change are wholly so. I think I have found out (here’s presumption!) the simple way by which species become exquisitely adapted to various ends.

At present we begin to feel impatient, and to wish for a new state of chemical elements. For a time the desire was to add to the metals, now we wish to diminish their number. They increase upon us continually, and threaten to enclose within their ranks the bounds of our fair fields of chemical science. The rocks of the mountain and the soil of the plain, the sands of the sea and the salts that are in it, have given way to the powers we have been able to apply to them, but only to be replaced by metals.

At the entrance to the observatory Stjerneborg located underground, Tycho Brahe built a Ionic portal. On top of this were three sculptured lions. On both sides were inscriptions and on the backside was a longer inscription in gold letters on a porfyr stone: Consecrated to the all-good, great God and Posterity. Tycho Brahe, Son of Otto, who realized that Astronomy, the oldest and most distinguished of all sciences, had indeed been studied for a long time and to a great extent, but still had not obtained sufficient firmness or had been purified of errors, in order to reform it and raise it to perfection, invented and with incredible labour, industry, and expenditure constructed various exact instruments suitable for all kinds of observations of the celestial bodies, and placed them partly in the neighbouring castle of Uraniborg, which was built for the same purpose, partly in these subterranean rooms for a more constant and useful application, and recommending, hallowing, and consecrating this very rare and costly treasure to you, you glorious Posterity, who will live for ever and ever, he, who has both begun and finished everything on this island, after erecting this monument, beseeches and adjures you that in honour of the eternal God, creator of the wonderful clockwork of the heavens, and for the propagation of the divine science and for the celebrity of the fatherland, you will constantly preserve it and not let it decay with old age or any other injury or be removed to any other place or in any way be molested, if for no other reason, at any rate out of reverence to the creator’s eye, which watches over the universe. Greetings to you who read this and act accordingly. Farewell!