[Man] … his origin, his growth, his hopes and fears, his loves and his beliefs are but the outcome of accidental collocations of atoms; that no fire, no heroism, no intensity of thought and feeling can preserve an individual life beyond the grave; that all the labour of the ages, all the devotion, all the inspiration, all the noonday brightness of human genius are destined to extinction in the vast death of the solar system, and that the whole temple of Man's achievement must inevitably be buried beneath the debris of a universe in ruins…

Science sans conscience n’est que le ruine de l’âme.
Knowledge without conscience is but the ruine of the soule.

And who can doubt that it will lead to the worst disorders when minds created free by God are compelled to submit slavishly to an outside will? When we are told to deny our senses and subject them to the whim of others? When people devoid of whatsoever competence are made judges over experts and are granted authority to treat them as they please? These are the novelties which are apt to bring about the ruin of commonwealths and the subversion of the state.

Applied research generates improvements, not breakthroughs. Great scientific advances spring from pure research. Even scientists renowned for their “useful” applied discoveries often achieved success only when they abandoned their ostensible applied-science goal and allowed their minds to soar—as when Alexander Fleming, “just playing about,” refrained from throwing away green molds that had ruined his experiment, studied them, and discovered penicillin. Or when C. A. Clarke, a physician affiliated with the University of Liverpool, became intrigued in the 1950s by genetically created color patterns that emerged when he cross-bred butterflies as a hobby. His fascination led him—“by the pleasant route of pursuing idle curiosity”—to the successful idea for preventing the sometimes fatal anemia that threatened babies born of a positive-Rhesus-factor father and a negative-Rhesus-factor mother.

As to Science, she has never sought to ally herself to civil power. She has never attempted to throw odium or inflict social ruin on any human being. She has never subjected anyone to mental torment, physical torture, least of all to death, for the purpose of upholding or promoting her ideas. She presents herself unstained by cruelties and crimes. But in the Vatican—we have only to recall the Inquisition—the hands that are now raised in appeals to the Most Merciful are crimsoned. They have been steeped in blood!

Atoms or systems into ruin hurl’d,
And now a bubble burst, and now a world.

Ay, driven no more by passion's gale,
Nor impulse unforeseen,
Humanity shall faint and fail,
And on her ruins will prevail
The Conquering Machine!
Responsibility begone!
Let Freedom's flag be furled;
Oh, coming ages, hasten on,
And bring the true Automaton,
The monarch of the world.

Babylon in all its desolation is a sight not so awful as that of the human mind in ruins.

Better far off to leave half the ruins and nine-tenths of the churches unseen and to see well the rest; to see them not once, but again and often again; to watch them, to learn them, to live with them, to love them, till they have become a part of life and life’s recollections.

But here it may be objected, that the present Earth looks like a heap of Rubbish and Ruines; And that there are no greater examples of confusion in Nature than Mountains singly or jointly considered; and that there appear not the least footsteps of any Art or Counsel either in the Figure and Shape, or Order and Disposition of Mountains and Rocks. Wherefore it is not likely they came so out of God's hands ... To which I answer, That the present face of the Earth with all its Mountains and Hills, its Promontaries and Rocks, as rude and deformed as they appear, seems to me a very beautiful and pleasant object, and with all the variety of Hills, and Valleys, and Inequalities far more grateful to behold, than a perfectly level Countrey without any rising or protuberancy, to terminate the sight: As anyone that hath but seen the Isle of Ely, or any the like Countrey must need acknowledge.

Changes That Have Occurred in the Globe: When we have seen with our own eyes a mountain progressing into a plain; that is to say, an immense boulder separating from this mountain and covering the fields; an entire castle broken into pieces over the ground; a river swallowed up which then bursts out from its abyss; clear marks of a vast amount of water having once flooded regions now inhabited, and a hundred vestiges of other transformations, then we are much more willing to believe that great changes altered the face of the earth, than a Parisian lady who knows only that the place where her house was built was once a cultivated field. However, a lady from Naples who has seen the buried ruins of Herculaneum, is much less subject to the bias which leads us to believe that everything has always been as it is today.

Considered in its entirety, psychoanalysis won’t do. It is an end product, moreover, like a dinosaur or a zeppelin, no better theory can ever be erected on its ruins, which will remain for ever one of the saddest and strangest of all landmarks in the history of twentieth century thought.

Drunkenness, the ruin of reason, the destruction of strength, premature old age, momentary death.

Every reformation ruins somebody.

Financial ruin from medical bills is almost exclusively an American disease.

For mining I cannot say much good except that its operations are generally short-lived. The extractable wealth is taken and the shafts, the tailings, and the ruins left, and in a dry country such as the American West the wounds men make in the earth do not quickly heal.

Fossil bones and footsteps and ruined homes are the solid facts of history, but the surest hints, the most enduring signs, lie in those miniscule genes. For a moment we protect them with our lives, then like relay runners with a baton, we pass them on to be carried by our descendents. There is a poetry in genetics which is more difficult to discern in broken bomes, and genes are the only unbroken living thread that weaves back and forth through all those boneyards.

Geological facts being of an historical nature, all attempts to deduce a complete knowledge of them merely from their still, subsisting consequences, to the exclusion of unexceptionable testimony, must be deemed as absurd as that of deducing the history of ancient Rome solely from the medals or other monuments of antiquity it still exhibits, or the scattered ruins of its empire, to the exclusion of a Livy, a Sallust, or a Tacitus.

Heroes and scholars represent the opposite extremes... The scholar struggles for the benefit of all humanity, sometimes to reduce physical effort, sometimes to reduce pain, and sometimes to postpone death, or at least render it more bearable. In contrast, the patriot sacrifices a rather substantial part of humanity for the sake of his own prestige. His statue is always erected on a pedestal of ruins and corpses... In contrast, all humanity crowns a scholar, love forms the pedestal of his statues, and his triumphs defy the desecration of time and the judgment of history.

If you advertise to tell lies, it will ruin you, but if you advertise to tell the public the truth, and particularly to give information, it will bring you success. I learned early that to tell a man how best to use tires, and to make him want them, was far better than trying to tell him that your tire is the best in the world. If you believe that yours is, let your customer find it out.

If you want to become a chemist, you will have to ruin your health. If you don’t ruin your health studying, you won’t accomplish anything these days in chemistry.

In science there is and will remain a Platonic element which could not be taken away without ruining it. Among the infinite diversity of singular phenomena science can only look for invariants.

It is both a sad and a happy fact of engineering history that disasters have been powerful instruments of change. Designers learn from failure. Industrial society did not invent grand works of engineering, and it was not the first to know design failure. What it did do was develop powerful techniques for learning from the experience of past disasters. It is extremely rare today for an apartment house in North America, Europe, or Japan to fall down. Ancient Rome had large apartment buildings too, but while its public baths, bridges and aqueducts have lasted for two thousand years, its big residential blocks collapsed with appalling regularity. Not one is left in modern Rome, even as ruin.

Many an otherwise good cathedral has been ruined by too many gargoyles.

Men fear thought as they fear nothing else on earth more than ruin more even than death. Thought is subversive and revolutionary, destructive and terrible, thought is merciless to privilege, established institutions, and comfortable habit. Thought looks into the pit of hell and is not afraid. Thought is great and swift and free, the light of the world, and the chief glory of man.

Men moralise among ruins.

Moreover, within the hollows of the earth,
When from one quarter the wind builds up, lunges,
Muscles the deep caves with its headstrong power,
The earth leans hard where the force of wind has pressed it;
Then above ground, the higher the house is built,
The nearer it rises to the sky, the worse
Will it lean that way and jut out perilously,
The beams wrenched loose and hanging ready to fall.
And to think, men can't believe that for this world
Some time of death and ruin lies in wait,
Yet they see so great a mass of earth collapse!
And the winds pause for breath—that's lucky, for else
No force could rein things galloping to destruction.
But since they pause for breath, to rally their force,
Come building up and then fall driven back,
More often the earth will threaten ruin than
Perform it. The earth will lean and then sway back,
Its wavering mass restored to the right poise.
That explains why all houses reel, top floor
Most then the middle, and ground floor hardly at all.

Natural causes, as we know, are at work, which tend to modify, if they do not at length destroy, all the arrangements and dimensions of the earth and the whole solar system. But though in the course of ages catastrophes have occurred and may yet occur in the heavens, though ancient systems may be dissolved and new systems evolved out of their ruins, the molecules [i.e. atoms] out of which these systems are built—the foundation stones of the material universe—remain unbroken and unworn. They continue to this day as they were created—perfect in number and measure and weight.

Now the American eagle is verging on extinction. Even the polar bear on its ice floes has become easy game for flying sportsmen. A peninsula named Udjung Kulon holds the last two or three dozen Javan rhinoceroses. The last known herd of Arabian oryx has been machine-gunned by a sheik. Blue whales have nearly been harpooned out of their oceans. Pollution ruins bays and rivers. Refuse litters beaches. Dam projects threaten Colorado canyons, Hudson valleys, every place of natural beauty that can be a reservoir for power. Obviously the scientific progress so alluring to me is destroying qualities of greater worth.

One of the great achievements of the 1950s and 1960s was a [TV] series called Your Life in Their Hands, which dealt with medical science. It presented the scientific evidence for the connection between tobacco and cancer, against the entrenched opposition, all of which you can quite easily imagine. … The “television doctor” … presented the evidence of the connection between the two over and over again on television. A lot of people tried to stop it, but he carried on. It ruined his career, I suspect, in the medical sense, but he stuck to his guns. It’s one of early television’s badges of honour.

Papyra, throned upon the banks of Nile,
Spread her smooth leaf, and waved her silver style.
The storied pyramid, the laurel’d bust,
The trophy’d arch had crumbled into dust;
The sacred symbol, and the epic song (Unknown the character, forgot the tongue,)
With each unconquer’d chief, or sainted maid,
Sunk undistinguish’d in Oblivion’s shade.
Sad o’er the scatter’d ruins Genius sigh’d,
And infant Arts but learn’d to lisp, and died.
Till to astonish’d realms Papyra taught To paint in mystic colours Sound and Thought,
With Wisdom’s voice to print the page sublime,
And mark in adamant the steps of Time.

Reason is the only ability that makes it possible for humans to rule the Earth and to ruin it.

Rocks have, no doubt, their grandeur, and there is a beauty in running waters, and even in placid lakes; but, let the rock be naked of vegetation down to and around its base, and its grandeur is painful,—it seems a ruin.

Science has nothing to be ashamed of even in the ruins of Nagasaki. The shame is theirs who appeal to other values than the human imaginative values which science has evolved. The shame is ours if we do not make science part of our world...

Science would be ruined if (like sports) it were to put competition above everything else, and if it were to clarify the rules of competition by withdrawing entirely into narrowly defined specialties. The rare scholars who are nomads-by-choice are essential to the intellectual welfare of the settled disciplines.

Take care of your health. ... Imagine Hercules as oarsman in a rotten boat; what can he do there but by the very force of his stroke expedite the ruin of his craft. Take care of the timbers of your boat. ... The formation of right habits is essential to your permanent security. They diminish your chance of falling when assaulted, and they augment your chance of recovery when overthrown.

The ruins of Machu Picchu are perched on top of a steep ridge in the most inaccessible corner of the most inaccessible section of the central Andes. No part of the highlands of Peru has been better defended by natural bulwarks—a stupendous canyon whose rim is more than a mile above the river, whose rock is granite, and whose precipices are frequently a thousand feet sheer.

This, as you know, is my opinion, that as the body when it tyrannizes over the mind ruins and destroys all its soundness, so in the same way when the mind becomes the tyrant, and not merely the true lord, it wastes and destroys the soundness of the body first, and then their common bond of union … and sins against prudence and charity.

Thus we conclude, that the strata both primary and secondary, both those of ancient and those of more recent origin, have had their materials furnished from the ruins of former continents, from the dissolution of rocks, or the destruction of animal or vegetable bodies, similar, at least in some respects, to those that now occupy the surface of the earth.

To wage war with Marchand or anyone else again will benefit nobody and bring little profit to science. You consume yourself in this way, you ruin your liver and eventually your nerves with Morrison pills. Imagine the year 1900 when we have disintegrated into carbonic acid, ammonia and water and our bone substance is perhaps once more a constituent of the bones of the dog who defiles our graves. Who will then worry his head as to whether we have lived in peace or anger, who then will know about your scientific disputes and of your sacrifice of health and peace of mind for science? Nobody. But your good ideas and the discoveries you have made, cleansed of all that is extraneous to the subject, will still be known and appreciated for many years to come. But why am I trying to advise the lion to eat sugar.

We are in the grip of a scientific materialism, caught in a vicious cycle where our security today seems to depend on regimentation and weapons which will ruin us tomorrow.

When I started on this problem I surveyed the field and selected the best road, regardless of the roads which others have taken. I knew the direction in which others had attempted to solve the problem, and was careful not to fall into the same rut which had led every previous effort into failure and ruin.

When the state is shaken to its foundations by internal or external events, when commerce, industry and all trades shall be at a stand, and perhaps on the brink of ruin; when the property and fortune of all are shaken or changed, and the inhabitants of towns look forward with dread and apprehension to the future, then the agriculturalist holds in his hand the key to the money chest of the rich, and the savings-box of the poor; for political events have not the slightest influence on the natural law, which forces man to take into his system, daily, a certain number of ounces of carbon and nitrogen.
Reflecting on events of 1848.

When you believe you have found an important scientific fact, and are feverishly curious to publish it, constrain yourself for days, weeks, years sometimes, fight yourself, try and ruin your own experiments, and only proclaim your discovery after having exhausted all contrary hypotheses. But when, after so many efforts you have at last arrived at a certainty, your joy is one of the greatest which can be felt by a human soul.