Children are to be guided to make a beginning in all the arts and sciences without interference with their spontaneity, the instinct of imitation being so used as to give them order without constraining them.

Darwinists are right to say that selection favours the organisms that leave alive the most progeny, but vigorous growth takes place within a constrained space where feedback from the environment allows the emergence of natural self-regulation.

Men are noisy, narrow-band devices, but their nervous systems have very many parallel and simultaneously active channels. Relative to men, computing machines are very fast and very accurate, but they are constrained to perform only one or a few elementary operations at a time. Men are flexible, capable of “programming themselves contingently” on the basis of newly received information. Computing machines are single-minded, constrained by their “pre-programming.”

Organisms are not billiard balls, propelled by simple and measurable external forces to predictable new positions on life’s pool table. Sufficiently complex systems have greater richness. Organisms have a history that constrains their future in myriad, subtle ways.

Scientists are not robotic inducing machines that infer structures of explanation only from regularities observed in natural phenomena (assuming, as I doubt, that such a style of reasoning could ever achieve success in principle). Scientists are human beings, immersed in culture, and struggling with all the curious tools of inference that mind permits ... Culture can potentiate as well as constrain–as Darwin’s translation of Adam Smith’s laissez-faire economic models into biology as the theory of natural selection. In any case, objective minds do not exist outside culture, so we must make the best of our ineluctable embedding.

Some of the men stood talking in this room, and at the right of the door a little knot had formed round a small table, the center of which was the mathematics student, who was eagerly talking. He had made the assertion that one could draw through a given point more than one parallel to a straight line; Frau Hagenström had cried out that this was impossible, and he had gone on to prove it so conclusively that his hearers were constrained to behave as though they understood.

Throughout his last half-dozen books, for example, Arthur Koestler has been conducting a campaign against his own misunderstanding of Darwinism. He hopes to find some ordering force, constraining evolution to certain directions and overriding the influence of natural selection ... Darwinism is not the theory of capricious change that Koestler imagines. Random variation may be the raw material of change, but natural selection builds good design by rejecting most variants while accepting and accumulating the few that improve adaptation to local environments.

We do not inhabit a perfected world where natural selection ruthlessly scrutinizes all organic structures and then molds them for optimal utility. Organisms inherit a body form and a style of embryonic development; these impose constraint s upon future change and adaptation. In many cases, evolutionary pathways reflect inherited patterns more than current environmental demands. These inheritances constrain, but they also provide opportunity. A potentially minor genetic change ... entails a host of complex, nonadaptive consequences ... What ‘play’ would evolution have if each structure were built for a restricted purpose and could be used for nothing else? How could humans learn to write if our brain had not evolved for hunting, social cohesion, or whatever, and could not transcend the adaptive boundaries of its original purpose?

We should have positive expectations of what is in the universe, not fears and dreads. We are made with the realization that we’re not Earthbound, and that our acceptance of the universe offers us room to explore and extend outward. It’s like being in a dark room and imagining all sorts of terrors. But when we turn on the light – technology - suddenly it’s just a room where we can stretch out and explore. If the resources here on Earth are limited, they are not limited in the universe. We are not constrained by the limitations of our planet. As children have to leave the security of family and home life to insure growth into mature adults, so also must humankind leave the security and familiarity of Earth to reach maturity and obtain the highest attainment possible for the human race.

When you believe you have found an important scientific fact, and are feverishly curious to publish it, constrain yourself for days, weeks, years sometimes, fight yourself, try and ruin your own experiments, and only proclaim your discovery after having exhausted all contrary hypotheses. But when, after so many efforts you have at last arrived at a certainty, your joy is one of the greatest which can be felt by a human soul.

Younger scientists cannot freely express their opinions without risking their ability to apply for grants or publish papers. Much worse than this, few of them can now follow that strange and serendipitous path that leads to deep discovery. They are not constrained by political or theological tyrannies, but by the ever-clinging hands of the jobsworths that form the vast tribe of the qualified but hampering middle management and the safety officials that surround them.