...after my first feeling of revulsion had passed, I spent three of the most entertaining and instructive weeks of my life studying the fascinating molds which appeared one by one on the slowly disintegrating mass of horse-dung. Microscopic molds are both very beautiful and absorbingly interesting. The rapid growth of their spores, the way they live on each other, the manner in which the different forms come and go, is so amazing and varied that I believe a man could spend his life and not exhaust the forms or problems contained in one plate of manure.

…so slow is moral progress. True, we have the bicycle, the motor-car, the dirigible airship and other marvellous means of breaking our bones; but our morality is not one rung the higher for it all. One would even say that, the farther we proceed in our conquest of matter, the more our morality recedes. The most advanced of our inventions consists in bringing men down with grapeshot and explosives with the swiftness of the reaper mowing the corn.

...the genes almost always accurately reproduce. If they don't, you get one of the following results: One, monsters—that is, grossly malformed babies resulting from genetic mistakes. Years ago most monsters died, but now many can be saved. This has made possible the National Football League.

…the simplicity, the indispensableness of each word, each letter, each little dash, that among all artists raises the mathematician nearest to the World-creator; it establishes a sublimity which is equalled in no other art,—Something like it exists at most in symphonic music.

...the study of butterflies—creatures selected as the types of airiness and frivolity—instead of being despised, will some day be valued as one of the most important branches of Biological science.

...they have never affirm'd any thing, concerning the Cause, till the Trial was past: whereas, to do it before, is a most venomous thing in the making of Sciences; for whoever has fix'd on his Cause, before he experimented; can hardly avoid fitting his Experiment to his Observations, to his own Cause, which he had before imagin'd; rather than the Cause to the Truth of the Experiment itself.
Referring to experiments of the Aristotelian mode, whereby a preconceived truth would be illustrated merely to convince people of the validity of the original thought.

...those experiments be not only esteemed which have an immediate and present use, but those principally which are of most universal consequence for invention of other experiments, and those which give more light to the invention of causes; for the invention of the mariner's needle, which giveth the direction, is of no less benefit for navigation than the invention of the sails, which give the motion.

“I’m not so sure he’s wrong about automobiles,” he said, “With all their speed forward they may be a step backward for civilization—that is, spiritual civilization … But automobiles have come, and they bring a greater change in our life than most of us expect. They are here, and almost all outward things are going to be different because of what they bring. They are going to alter war, and they are going to alter peace.”

“Men die of the diseases which they have studied most,” remarked the surgeon, snipping off the end of a cigar with all his professional neatness and finish. “It’s as if the morbid condition was an evil creature which, when it found itself closely hunted, flew at the throat of its pursuer. If you worry the microbes too much they may worry you. I’ve seen cases of it, and not necessarily in microbic diseases either. There was, of course, the well-known instance of Liston and the aneurism; and a dozen others that I could mention.”

“Obvious” is the most dangerous word in mathematics.

“Planning” is simply the result of experience read backward and projected into the future. To me the “purposive” action of a beehive is simply the summation and integration of its units, and Natural Selection has put higher and higher premiums on the most “purposeful” integration. It is the same way (to me) in the evolution of the middle ear, the steps in the Cynodonts (clearly shown by me in 1910 and by you later in Oudenodon) make it easier to see how such a wonderful device as the middle ear could arise without any predetermination or human-like planning, and in fact in the good old Darwinian way, if only we admit that as the “twig is bent the tree’s inclined” and that each stage conserves the advantages of its predecessors… The simple idea that planning is only experience read backward and combined by selection in suitable or successful combinations takes the mystery out of Nature and out of men’s minds.

“Science studies everything,” say the scientists. But, really, everything is too much. Everything is an infinite quantity of objects; it is impossible at one and the same time to study all. As a lantern cannot light up everything, but only lights up the place on which it is turned or the direction in which the man carrying it is walking, so also science cannot study everything, but inevitably only studies that to which its attention is directed. And as a lantern lights up most strongly the place nearest to it, and less and less strongly objects that are more and more remote from it, and does not at all light up those things its light does not reach, so also human science, of whatever kind, has always studied and still studies most carefully what seems most important to the investigators, less carefully what seems to them less important, and quite neglects the whole remaining infinite quantity of objects. ... But men of science to-day ... have formed for themselves a theory of “science for science's sake,” according to which science is to study not what mankind needs, but everything.

“These changes in the body,” he wrote in the review paper he sent to the American Journal of Physiology late in 1913, “are, each one of them, directly serviceable in making the organism more efficient in the struggle which fear or rage or pain may involve; for fear and rage are organic preparations for action, and pain is the most powerful known stimulus to supreme exertion. The organism which with the aid of increased adrenal secretion can best muster its energies, can best call forth sugar to supply the labouring muscles, can best lessen fatigue, and can best send blood to the parts essential in the run or the fight for life, is most likely to survive. Such, according to the view here propounded, is the function of the adrenal medulla at times of great emergency.”

“Why do you think it is…”, I asked Dr. Cook … “that brain surgery, above all else—even rocket science—gets singled out as the most challenging of human feats, the one demanding the utmost of human intelligence?”
[Dr. Cook answered,] “No margin for error.”

[A contemporary study] predicted the loss of two-thirds of all tropical forests by the turn of the century. Hundreds of thousands of species will perish, and this reduction of 10 to 20 percent of the earth’s biota will occur in about half a human life span. … This reduction of the biological diversity of the planet is the most basic issue of our time.

[A crowd] thinks in images, and the image itself calls up a series of other images, having no logical connection with the first … A crowd scarcely distinguishes between the subjective and the objective. It accepts as real the images invoked in its mind, though they most often have only a very distant relation with the observed facts. * * * Crowds being only capable of thinking in images are only to be impressed by images. It is only images that terrify or attract them and become motives of action.

[An artist] will sooner and with more certainty, establish the character of skeletons, than the most learned anatomist, whose eye has not been accustomed to seize on every peculiarity.
Asserting his (incorrect) belief that the fossil teeth of the mastodon revealed it was a carnivorous animal.]

[Audubon’s works are] the most splendid monuments which art has erected in honor of ornithology.

[Bolyai’s Science Absolute of Space is] the most extraordinary two dozen pages in the history of thought!

[Certain students] suppose that because science has penetrated the structure of the atom it can solve all the problems of the universe. ... They are known in every ... college as the most insufferable, cocksure know-it-alls. If you want to talk to them about poetry, they are likely to reply that the "emotive response" to poetry is only a conditioned reflex .... If they go on to be professional scientists, their sharp corners are rubbed down, but they undergo no fundamental change. They most decidedly are not set apart from the others by their intellectual integrity and faith, and their patient humility in front of the facts of nature.... They are uneducated, in the fullest sense of the word, and they certainly are no advertisement for the claims of science teachers.

[Decoding the human genome sequence] is the most significant undertaking that we have mounted so far in an organized way in all of science. I believe that reading our blueprints, cataloguing our own instruction book, will be judged by history as more significant than even splitting the atom or going to the moon.

[Describing a freshman seminar titled “How the Tabby Cat Got Her Stripes or The Silence of the Genes”:] The big idea we start with is: “How is the genome interpreted, and how are stable decisions that affect gene expression inherited from one cell to the next? This is one of the most competitive areas of molecular biology at the moment, and the students are reading papers that in some instances were published this past year. As a consequence, one of the most common answers I have to give to their questions is, “We just don't know.”

[Dubious attribution] I was wise enough never to grow up, while fooling most people into believing that I had.

[E.H.] Moore was presenting a paper on a highly technical topic to a large gathering of faculty and graduate students from all parts of the country. When half way through he discovered what seemed to be an error (though probably no one else in the room observed it). He stopped and re-examined the doubtful step for several minutes and then, convinced of the error, he abruptly dismissed the meeting—to the astonishment of most of the audience. It was an evidence of intellectual courage as well as honesty and doubtless won for him the supreme admiration of every person in the group—an admiration which was in no wise diminished, but rather increased, when at a later meeting he announced that after all he had been able to prove the step to be correct.

[Helmholtz] is not a philosopher in the exclusive sense, as Kant, Hegel, Mansel are philosophers, but one who prosecutes physics and physiology, and acquires therein not only skill in developing any desideratum, but wisdom to know what are the desiderata, e.g., he was one of the first, and is one of the most active, preachers of the doctrine that since all kinds of energy are convertible, the first aim of science at this time. should be to ascertain in what way particular forms of energy can be converted into each other, and what are the equivalent quantities of the two forms of energy.

[Herschel and Humboldt] stirred up in me a burning zeal to add even the most humble contribution to the noble structure of Natural Science. No one or a dozen other books influenced me nearly so much as these two. I copied out from Humboldt long passages about Teneriffe and read them aloud on one of [my walking excursions].

[I] browsed far outside science in my reading and attended public lectures - Bertrand Russell, H. G. Wells, Huxley, and Shaw being my favorite speakers. (The last, in a meeting at King's College, converted me to vegetarianism - for most of two years!).

[In 18th-century Britain] engineers for the most began as simple workmen, skilful and ambitious but usually illiterate and self-taught. They were either millwrights like Bramah, mechanics like Murdoch and George Stephenson, or smiths like Newcomen and Maudslay.

[In mathematics] we behold the conscious logical activity of the human mind in its purest and most perfect form. Here we learn to realize the laborious nature of the process, the great care with which it must proceed, the accuracy which is necessary to determine the exact extent of the general propositions arrived at, the difficulty of forming and comprehending abstract concepts; but here we learn also to place confidence in the certainty, scope and fruitfulness of such intellectual activity.

[Karl F. Meyer was] the most versatile microbe hunter since Pasteur.

[Kepler] had to realize clearly that logical-mathematical theoretizing, no matter how lucid, could not guarantee truth by itself; that the most beautiful logical theory means nothing in natural science without comparison with the exactest experience. Without this philosophic attitude, his work would not have been possible.

[Lifting off into space] I wasn’t really scared. I was very excited, and I was very anxious. When you’re getting ready to launch into space, you’re sitting on a big explosion waiting to happen. So most astronauts getting ready to lift off are excited and very anxious and worried about that explosion—because if something goes wrong in the first seconds of launch, there's not very much you can do.

[Luis] Alvarez could no more refrain from invention than he could from breathing. In the midst of an illness so severe as to incapacitate him for most of a summer, he amused himself by attempting to build a better detector of gallstones.

[M]y work, which I’ve done for a long time, was not pursued in order to gain the praise I now enjoy, but chiefly from a craving after knowledge, which I notice resides in me more than in most other men. And therewithal, whenever I found out anything remarkable, I have thought it my duty to put down my discovery on paper, so that all ingenious people might be informed thereof.

[My study of the universe] leaves little doubt that life has occurred on other planets. I doubt if the human race is the most intelligent form of life.

[On Oxygen, Chlorine, Iodine, Fluorine:] The most important division of ponderable substances seems to be that which represents their electrical energies or their respective inherent states. When the poles of a voltaic apparatus are introduced into a mixture of the simple substances, it is found that four of them go to the positive, while the rest evince their state by passing to the negative pole. As this division coincides with one resulting from a consideration of their most important properties, it is that which I shall adopt as the first.

[Other than fossils,] the most important of these other records of creation is, without doubt, ontogeny, that is, the history of the developmment of the organic individual (embryology and motamorphology). It briefly repeats in great and marked features the series of forms which the ancestors of the respective individuals have passed through from the beginning of their tribe. We have designated the palaeontological history of the development of the ancestors of a living form as the history of a tribe, or phylogeny, and we may therefore thus enunciate this exceedingly important biogenetic fundamental principle: “Ontogeny is a short and quick repetition, or recapitulation, of Phylogeny, determined by the laws of Inheritance and Adaptation.”

[Shawn Lawrence Otto describes the damaging] strategy used to undermine science in the interest of those industries where science has pointed out the dangers of their products to individuals and human life in general … [It was] used a generation ago by the tobacco industry… First they manufacture uncertainty by raising doubts about even the most indisputable scientific evidence. Then they launder information by using seemingly independent front organizations to promote their desired message and thereby confuse the public. And finally they recruit unscrupulous scientific spokespeople to misrepresent peer-reviewed scientific findings and cherry-pick facts in an attempt to persuade the media and the public that there is still serious debate among scientists on the issue at hand.

[The famous attack of Sir William Hamilton on the tendency of mathematical studies] affords the most express evidence of those fatal lacunae in the circle of his knowledge, which unfitted him for taking a comprehensive or even an accurate view of the processes of the human mind in the establishment of truth. If there is any pre-requisite which all must see to be indispensable in one who attempts to give laws to the human intellect, it is a thorough acquaintance with the modes by which human intellect has proceeded, in the case where, by universal acknowledgment, grounded on subsequent direct verification, it has succeeded in ascertaining the greatest number of important and recondite truths. This requisite Sir W. Hamilton had not, in any tolerable degree, fulfilled. Even of pure mathematics he apparently knew little but the rudiments. Of mathematics as applied to investigating the laws of physical nature; of the mode in which the properties of number, extension, and figure, are made instrumental to the ascertainment of truths other than arithmetical or geometrical—it is too much to say that he had even a superficial knowledge: there is not a line in his works which shows him to have had any knowledge at all.

[The mathematician's] subject is the most curious of all—there is none in which truth plays such odd pranks. It has the most elaborate and the most fascinating technique, and gives unrivaled openings for the display of sheer professional skill.

[The nanotube] brings those properties you cannot get from other organic molecules. And it’s still carbon, so it has organic chemistry. Here is an object that has, to a superlative degree, the aspects that we hold most central to the inorganic world: hardness, toughness, terrific strength, thermal and electrical conductivity. Things you just can’t do with bone and wood. But it’s made out of carbon. It’s something that plays the game at the same level of perfection as molecules and life.

[The screw machine] was on the principle of the guage or sliding lathe now in every workshop throughout the world; the perfection of which consists in that most faithful agent gravity, making the joint, and that almighty perfect number three, which is in harmony itself. I was young when I learned that principle. I had never seen my grandmother putting a chip under a three-legged milking-stool; but she always had to put a chip under a four-legged table, to keep it steady. I cut screws of all dimensions by this machine, and did them perfectly. (1846)

[The steamboat] will answer for sea voyages as well as for inland navigation, in particular for packets, where there may be a great number of passengers. He is also of opinion, that fuel for a short voyage would not exceed the weight of water for a long one, and it would produce a constant supply of fresh water. ... [T]he boat would make head against the most violent tempests, and thereby escape the danger of a lee shore; and that the same force may be applied to a pump to free a leaky ship of her water. ... [T]he good effects of the machine, is the almost omnipotent force by which it is actuated, and the very simple, easy, and natural way by which the screws or paddles are turned to answer the purpose of oars.
[This letter was written in 1785, before the first steamboat carried a man (Fitch) on 27 Aug 1787.]

[The sun] … which alone we should judge to be worthy of the most high God, if He should be pleased with a material domicile, and choose a place in which to dwell with the blessed angels.

[To a man expecting a scientific proof of the impossibility of flying saucers] I might have said to him: “Listen, I mean that from my knowledge of the world that I see around me, I think that it is much more likely that the reports of flying saucers are the results of the known irrational characteristics of terrestrial intelligence than of the unknown rational efforts of extra-terrestrial intelligence.” It is just more likely, that is all. It is a good guess. And we always try to guess the most likely explanation, keeping in the back of the mind the fact that if it does not work we must discuss the other possibilities.

[To elucidate using models] the different combining powers in elementary atoms, I … select my illustrations from that most delightful of games, croquet. Let the croquet balls represent our atoms, and let us distinguish the atoms of different elements by different colours. The white balls are hydrogen, the green ones chlorine atoms; the atoms of fiery oxygen are red, those of nitrogen, blue; the carbon atoms, lastly, are naturally represented by black balls. But we have, in addition, exhibit the different combining powers of these atoms … by screwing into the balls a number of metallic arms (tubes and pins), which correspond respectively to the combining powers of the atoms represented … to join the balls … in imitation of the atomic edifices represented.

[W]e have made a thing, a most terrible weapon, that has altered abruptly and profoundly the nature of the world. We have made a thing that, by all standards of the world we grew up in, is an evil thing. And by doing so, by our participation in making it possible to make these things, we have raised again the question of whether science is good for man, of whether it is good to learn about the world, to try to understand it, to try to control it, to help give to the world of men increased insight, increased power. Because we are scientists, we must say an unalterable yes to these questions; it is our faith and our commitment, seldom made explicit, even more seldom challenged, that knowledge is a good in itself, knowledge and such power as must come with it.

[W]hen Galileo discovered he could use the tools of mathematics and mechanics to understand the motion of celestial bodies, he felt, in the words of one imminent researcher, that he had learned the language in which God recreated the universe. Today we are learning the language in which God created life. We are gaining ever more awe for the complexity, the beauty, the wonder of God's most devine and sacred gift.

[Describing the effects of over-indulgence in wine:]
But most too passive, when the blood runs low
Too weakly indolent to strive with pain,
And bravely by resisting conquer fate,
Try Circe's arts; and in the tempting bowl
Of poisoned nectar sweet oblivion swill.
Struck by the powerful charm, the gloom dissolves
In empty air; Elysium opens round,
A pleasing frenzy buoys the lightened soul,
And sanguine hopes dispel your fleeting care;
And what was difficult, and what was dire,
Yields to your prowess and superior stars:
The happiest you of all that e'er were mad,
Or are, or shall be, could this folly last.
But soon your heaven is gone: a heavier gloom
Shuts o'er your head; and, as the thundering stream,
Swollen o'er its banks with sudden mountain rain,
Sinks from its tumult to a silent brook,
So, when the frantic raptures in your breast
Subside, you languish into mortal man;
You sleep, and waking find yourself undone,
For, prodigal of life, in one rash night
You lavished more than might support three days.
A heavy morning comes; your cares return
With tenfold rage. An anxious stomach well
May be endured; so may the throbbing head;
But such a dim delirium, such a dream,
Involves you; such a dastardly despair
Unmans your soul, as maddening Pentheus felt,
When, baited round Citheron's cruel sides,
He saw two suns, and double Thebes ascend.

[Question: What do you think was the most important physics idea to emerge this year?]
We won't know for a few years.

A stands for atom; it is so small No one has ever seen it at all.
B stands for bomb; the bombs are much bigger,
So, brother, do not be too fast on the trigger.
H has become a most ominous letter.
It means something bigger if not something better.

But how shall we this union well expresse?
Naught tyes the soule: her subtiltie is such
She moves the bodie, which she doth possesse.
Yet no part toucheth, but by Vertue's touch.
Then dwels she not therein as in a tent;
Nor as a pilot in his Ship doth sit;
Nor as the spider in his web is pent;
Nor as the Waxe retaines the print in it;
Nor as a Vessell water doth containe;
Nor as one Liquor in another shed;
Nor as the heate dath in the fire remaine;
Nor as a voice throughout the ayre is spred;
But as the faire and cheerfull morning light,
Doth here, and there, her silver beames impart,
And in an instant doth her selfe unite
To the transparent Aire, in all, and part:
Still resting whole, when blowes the Aire devide;
Abiding pure, when th' Aire is most corrupted;
Throughout the Aire her beames dispersing wide,
And when the Aire is tost, not interrupted:
So doth the piercing Soule the body fill;
Being all in all, and all in part diffus'd;
Indivisible, incorruptible still,
Not forc't, encountred, troubled or confus'd.
And as the Sunne above the light doth bring,
Tough we behold it in the Aire below;
So from th'eternall light the Soule doth spring,
Though in the Bodie she her powers do show.

Combien de gens se font abstraits pour paraître profonds! La plupart des termes abstraits sont des ombres qui cachent des vides.
How many people become abstract in order to appear profound! Most abstract terms are shadows that conceal a void.

Dilbert: I’m obsessed with inventing a perpetual motion machine. Most scientists think it's impossible, but I have something they don’t.
Dogbert: A lot of spare time?
Dilbert: Exactly.

Eine brennendste Zeitfrage allerdings! Es brennt in allen Ecken und Enden der ethnologischen Welt, brennt hell, lichterloh, in vollster Brunst, es brennt ringsum, Gross Feuer! und Niemand regt eine Hand.
A most burning question of time, though. It burns in every nook and cranny of the ethnological world, burning, bright, brightly, in the fullest blaze, and it burns all around, huge fire! and no one lifts a hand.
[Expressing his desperation over the loss of the cultural memory of ethnic traditions as so many cultures were no longer living in isolation.]

Engineering, too, owes its most useful materials to the achievements of chemists in identifying, separating, and transforming materials: structural steel for the framework of bridges and buildings, portland cement for roadways and aqueducts, pure copper for the electrical industries, aluminum alloys for automobiles and airplanes, porcelain for spark plugs and electrical insulators. The triumphs of engineering skill rest on a chemical foundation.

I. Animals have an electricity peculiar to themselves to which the name animal electricity is given.
II. The organs in which animal electricity acts above all others, and by which it is distributed throughout the whole body, are the nerves, and the most important organ of secretion is the brain.

In primis, hominis est propria VERI inquisitio atque investigato. Itaque cum sumus negotiis necessariis, curisque vacui, tum avemus aliquid videre, audire, ac dicere, cognitionemque rerum, aut occultarum aut admirabilium, ad benè beatéque vivendum necessariam ducimus; —ex quo intelligitur, quod VERUM, simplex, sincerumque sit, id esse naturæ hominis aptissimum. Huic veri videndi cupiditati adjuncta est appetitio quædam principatûs, ut nemini parere animus benè a naturâ informatus velit, nisi præcipienti, aut docenti, aut utilitatis causâ justè et legitimè imperanti: ex quo animi magnitudo existit, et humanarum rerum contemtio.
Before all other things, man is distinguished by his pursuit and investigation of TRUTH. And hence, when free from needful business and cares, we delight to see, to hear, and to communicate, and consider a knowledge of many admirable and abstruse things necessary to the good conduct and happiness of our lives: whence it is clear that whatsoever is TRUE, simple, and direct, the same is most congenial to our nature as men. Closely allied with this earnest longing to see and know the truth, is a kind of dignified and princely sentiment which forbids a mind, naturally well constituted, to submit its faculties to any but those who announce it in precept or in doctrine, or to yield obedience to any orders but such as are at once just, lawful, and founded on utility. From this source spring greatness of mind and contempt of worldly advantages and troubles.

La chaleur pénètre, comme la gravité, toutes les substances de l’univers, ses rayons occupent toutes les parties de l’espace. Le but de notre ouvrage est d’exposer les lois mathématiques que suit cet élément. Cette théorie formera désormais une des branches les plus importantes de la physique générale.
Heat, like gravity, penetrates every substance of the universe, its rays occupy all parts of space. The object of our work is to set forth the mathematical laws which this element obeys. The theory of heat will hereafter form one of the most important branches of general physics.

La santé est le trésor le plus précieux et le plus facile à perdre; c'est cependant le plus mal gardé.
Health is the most valuable and most easily lost treasure; yet it is the most poorly kept.

Les médecins les plus savans en théorie sont rarement les plus habile practiciens.
The doctors most learned in theory are seldom the most skilled practitioners.

Prospero: Hast thou, spirit,
Performed, to point, the tempest that I bade thee?
Ariel: To every article.
I boarded the king’s ship. Now on the beak,
Now in the waist, the deck, in every cabin,
I flamed amazement.
Sometime I’d divide
And burn in many places; on the topmast,
The yards, and bowsprit would I flame distinctly,
Then meet and join. Jove’s lightnings, the precursors
O’ th’ dreadful thunderclaps, more momentary
And sight-outrunning were not. The fire and cracks
Of sulphurous roaring the most mighty Neptune
Seem to besiege, and make his bold waves tremble;
Yea, his dread trident shake.

Question: If you walk on a dry path between two walls a few feet apart, you hear a musical note or “ring” at each footstep. Whence comes this?
Answer: This is similar to phosphorescent paint. Once any sound gets between two parallel reflectors or walls, it bounds from one to the other and never stops for a long time. Hence it is persistent, and when you walk between the walls you hear the sounds made by those who walked there before you. By following a muffin man down the passage within a short time you can hear most distinctly a musical note, or, as it is more properly termed in the question, a “ring” at every (other) step.

Question: If you were to pour a pound of molten lead and a pound of molten iron, each at the temperature of its melting point, upon two blocks of ice, which would melt the most ice, and why?
Answer: This question relates to diathermancy. Iron is said to be a diathermanous body (from dia, through, and thermo, I heat), meaning that it gets heated through and through, and accordingly contains a large quantity of real heat. Lead is said to be an athermanous body (from a, privative, and thermo, I heat), meaning that it gets heated secretly or in a latent manner. Hence the answer to this question depends on which will get the best of it, the real heat of the iron or the latent heat of the lead. Probably the iron will smite furthest into the ice, as molten iron is white and glowing, while melted lead is dull.

Surtout l’astronomie et l’anatomie sont les deux sciences qui nous offrent le plus sensiblement deux grands caractères du Créateur; l’une, son immensité, par les distances, la grandeur, et le nombre des corps célestes; l’autre, son intelligence infinie, par la méchanique des animaux.
Above all, astronomy and anatomy are the two sciences which present to our minds most significantly the two grand characteristics of the Creator; the one, His immensity, by the distances, size, and number of the heavenly bodies; the other, His infinite intelligence, by the mechanism of animate beings.

That the general characters of the big group to which the embryo belongs appear in development earlier than the special characters. In agreement with this is the fact that the vesicular form is the most general form of all; for what is common in a greater degree to all animals than the opposition of an internal and an external surface?
The less general structural relations are formed after the more general, and so on until the most special appear.
The embryo of any given form, instead of passing through the state of other definite forms, on the contrary separates itself from them.
Fundamentally the embryo of a higher animal form never resembles the adult of another animal form, but only its embryo.

Tout homme qui reçoit une éducation libérale compte aujourd'hui la chimie parmi les objets les plus indispensables de ses études.
Everyone who receives a liberal education today counts chemistry among the most essential parts of his studies.

Trimming consists of clipping off little bits here and there from those observations which differ most in excess from the mean, and in sticking them onto those which are too small; a species of 'equitable adjustment,' as a radical would term it, which cannot be admitted in science.

CALPURNIA: When beggars die there are no comets seen;
The heavens themselves blaze forth the death of princes.
CAESAR: Cowards die many times before their deaths;
The valiant never taste of death but once.
Of all the wonders that I have yet heard,
It seems to me most strange that men should fear,
Seeing that death, a necessary end,
Will come when it will come.

CLAUDIO: Death is a fearful thing.
ISABELLA: And shamed life a hateful.
CLAUDIO: Ay, but to die, and go we know not where;
To lie in cold obstruction, and to rot;
This sensible warm motion to become
A kneaded clod; and the delighted spirit
To bathe in fiery floods, or to reside
In thrilling region of thick-ribbed ice;
To be imprisioned in the viewless winds,
And blown with restless violence round about
The pendant world; or to be worst than worst
Of those lawless and incertain thought
Imagine howling—'tis too horrible!
The weariest and most loathed worldly life
That age, ache, penury, and imprisionment
Can lay on nature is a paradise
To what we fear of death.

~~[need primary source]~~ One of the most frightening things in the Western world and in this country in particular is the number of people who believe in things that are scientifically false. If someone tells me that the earth is less than 10000 years old in my opinion he should see a psychiatrist.

~~[Unverified]~~ The strongest affection and utmost zeal should, I think, promote the studies concerned with the most beautiful objects. This is the discipline that deals with the universe’s divine revolutions, the stars’ motions, sizes, distances, risings and settings . . . for what is more beautiful than heaven?

1839—The fermentation satire
THE MYSTERY OF ALCOHOLIC FERMENTATION RESOLVED
(Preliminary Report by Letter) Schwindler
I am about to develop a new theory of wine fermentation … Depending on the weight, these seeds carry fermentation to completion somewhat less than as in the beginning, which is understandable … I shall develop a new theory of wine fermentation [showing] what simple means Nature employs in creating the most amazing phenomena. I owe it to the use of an excellent microscope designed by Pistorius.
When brewer’s yeast is mixed with water the microscope reveals that the yeast dissolves into endless small balls, which are scarcely 1/800th of a line in diameter … If these small balls are placed in sugar water, it can be seen that they consist of the eggs of animals. As they expand, they burst, and from them develop small creatures that multiply with unbelievable rapidity in a most unheard of way. The form of these animals differs from all of the 600 types described up until now. They possess the shape of a Beinsdorff still (without the cooling apparatus). The head of the tube is a sort of proboscis, the inside of which is filled with fine bristles 1/2000th of a line long. Teeth and eyes are not discernible; however, a stomach, intestinal canal, anus (a rose red dot), and organs for secretion of urine are plainly discernible. From the moment they are released from the egg one can see these animals swallow the sugar from the solution and pass it to the stomach. It is digested immediately, a process recognized easily by the resultant evacuation of excrements. In a word, these infusors eat sugar, evacuate ethyl alcohol from the intestinal canal, and carbon dioxide from the urinary organs. The bladder, in the filled state, has the form of a champagne bottle; when empty, it is a small button … As soon as the animals find no more sugar present, they eat each other up, which occurs through a peculiar manipulation; everything is digested down to the eggs which pass unchanged through the intestinal canal. Finally, one again fermentable yeast, namely the seed of the animals, which remain over.

A … difference between most system-building in the social sciences and systems of thought and classification of the natural sciences is to be seen in their evolution. In the natural sciences both theories and descriptive systems grow by adaptation to the increasing knowledge and experience of the scientists. In the social sciences, systems often issue fully formed from the mind of one man. Then they may be much discussed if they attract attention, but progressive adaptive modification as a result of the concerted efforts of great numbers of men is rare.

A “pacifist male” is a contradiction in terms. Most self-described “pacifists” are not pacific; they simply assume false colors. When the wind changes, they hoist the Jolly Roger.

A calculating engine is one of the most intricate forms of mechanism, a telegraph key one of the simplest. But compare their value.

A child’s world is fresh and new and beautiful, full of wonder and excitement. It is our misfortune that for most of us that clear-eyed vision, that true instinct for what is beautiful and awe-inspiring, is dimmed and even lost before we reach adulthood.

A circumstance which influenced my whole career more than any other … was my friendship with Professor Henslow … a man who knew every branch of science…. During the latter half of my time at Cambridge [I] took long walks with him on most days; so that I was called by some of the dons “the man who walks with Henslow.”

A closer look at the course followed by developing theory reveals for a start that it is by no means as continuous as one might expect, but full of breaks and at least apparently not along the shortest logical path. Certain methods often afforded the most handsome results only the other day, and many might well have thought that the development of science to infinity would consist in no more than their constant application. Instead, on the contrary, they suddenly reveal themselves as exhausted and the attempt is made to find other quite disparate methods. In that event there may develop a struggle between the followers of the old methods and those of the newer ones. The former's point of view will be termed by their opponents as out-dated and outworn, while its holders in turn belittle the innovators as corrupters of true classical science.

A discovery in science, or a new theory, even when it appears most unitary and most all-embracing, deals with some immediate element of novelty or paradox within the framework of far vaster, unanalysed, unarticulated reserves of knowledge, experience, faith, and presupposition. Our progress is narrow; it takes a vast world unchallenged and for granted. This is one reason why, however great the novelty or scope of new discovery, we neither can, nor need, rebuild the house of the mind very rapidly. This is one reason why science, for all its revolutions, is conservative. This is why we will have to accept the fact that no one of us really will ever know very much. This is why we shall have to find comfort in the fact that, taken together, we know more and more.

A fair number of people who go on to major in astronomy have decided on it certainly by the time they leave junior high, if not during junior high. I think it’s somewhat unusual that way. I think most children pick their field quite a bit later, but astronomy seems to catch early, and if it does, it sticks.

A few days afterwards, I went to him [the same actuary referred to in another quote] and very gravely told him that I had discovered the law of human mortality in the Carlisle Table, of which he thought very highly. I told him that the law was involved in this circumstance. Take the table of the expectation of life, choose any age, take its expectation and make the nearest integer a new age, do the same with that, and so on; begin at what age you like, you are sure to end at the place where the age past is equal, or most nearly equal, to the expectation to come. “You don’t mean that this always happens?”—“Try it.” He did try, again and again; and found it as I said. “This is, indeed, a curious thing; this is a discovery!” I might have sent him about trumpeting the law of life: but I contented myself with informing him that the same thing would happen with any table whatsoever in which the first column goes up and the second goes down.

A field is the most just possession for men. For what nature requires it carefully bears: barley, oil, wine, figs, honey. Silver-plate and purple will do for the tragedians, not for life.

A fossil hunter needs sharp eyes and a keen search image, a mental template that subconsciously evaluates everything he sees in his search for telltale clues. A kind of mental radar works even if he isn’t concentrating hard. A fossil mollusk expert has a mollusk search image. A fossil antelope expert has an antelope search image. … Yet even when one has a good internal radar, the search is incredibly more difficult than it sounds. Not only are fossils often the same color as the rocks among which they are found, so they blend in with the background; they are also usually broken into odd-shaped fragments. … In our business, we don’t expect to find a whole skull lying on the surface staring up at us. The typical find is a small piece of petrified bone. The fossil hunter’s search therefore has to have an infinite number of dimensions, matching every conceivable angle of every shape of fragment of every bone on the human body.
Describing the skill of his co-worker, Kamoya Kimeu, who discovered the Turkana Boy, the most complete specimen of Homo erectus, on a slope covered with black lava pebbles.

A good ornithologist should be able to distinguish birds by their air as well as by their colors and shape; on the ground as well as on the wing, and in the bush as well as in the hand. For, though it must not be said that every species of birds has a manner peculiar to itself, yet there is somewhat, in most genera at least, that at first sight discriminates them and enables a judicious observer to pronounce upon them with some certainty.

A government, at bottom, is nothing more than a gang of men, and as a practical matter most of them are inferior men ... Government is actually the worst failure of civilized man. There has never been a really good one, and even those that are most tolerable are arbitrary, cruel, grasping and unintelligent. Indeed, it would not be far wrong to describe the best as the common enemy of all decent citizens.

A habit of basing convictions upon evidence, and of giving to them only that degree or certainty which the evidence warrants, would, if it became general, cure most of the ills from which the world suffers.

A hot topic of late, expressed most notably in Bernie Siegel’s best-selling books, has emphasized the role of positive attitude in combating such serious diseases as cancer. From the depths of my skeptical and rationalist soul, I ask the Lord to protect me from California touchie-feeliedom.

A huge net is being dragged across the sea floor, destroying everything in its path. Ahead of it bloom undersea forests and their hundreds and thousands of living creatures, both plant and animal; behind it is a desert. The net is pulled to the surface and most of the dead and dying life forms in it are thrown out. A few marketable species are retained. [Trawling] is like taking a front-end loader and scraping up your entire front garden and shredding it, keeping a few pebbles, and dumping the rest of it down the drain.

A marine protozoan is an aqueous salty system in an aqueous salty medium, but a man is an aqueous salty system in a medium in which there is but little water and most of that poor in salts.

A mathematical point is the most indivisble and unique thing which art can present.

A mere inference or theory must give way to a truth revealed; but a scientific truth must be maintained, however contradictory it may appear to the most cherished doctrines of religion.

A million years is a short time—the shortest worth messing with for most problems. You begin tuning your mind to a time scale that is the planet’s time scale. For me, it is almost unconscious now and is a kind of companionship with the earth.

A most vile face! and yet she spends me forty pound a year in Mercury and Hogs Bones. All her teeth were made in the Black-Fryars, both her Eyebrows i’ the Strand, and her Hair in Silver-street. Every part of Town owns a Piece of her.

A multidisciplinary study group ... estimated that it would be 1980 before developments in artificial intelligence make it possible for machines alone to do much thinking or problem solving of military significance. That would leave, say, five years to develop man-computer symbiosis and 15 years to use it. The 15 may be 10 or 500, but those years should be intellectually the most creative and exciting in the history of mankind.

A multitude of words doth rather obscure than illustrate, they being a burden to the memory, and the first apt to be forgotten, before we come to the last. So that he that uses many words for the explaining of any subject, doth, like the cuttle-fish, hide himself, for the most part, in his own ink.

A Native American elder once described his own inner struggles in this manner: Inside of me there are two dogs. One of the dogs is mean and evil. The other dog is good. The mean dog fights the good dog all the time. When asked which dog wins, he reflected for a moment and replied, The one I feed the most.

A neurotic person can be most simply described as someone who, while he was growing up, learned ways of behaving that are self-defeating in his society.

A noteworthy and often-remarked similarity exists between the facts and methods of geology and those of linguistic study. The science of language is, as it were, the geology of the most modern period, the Age of the Man, having for its task to construct the history of development of the earth and its inhabitants from the time when the proper geological record remains silent … The remains of ancient speech are like strata deposited in bygone ages, telling of the forms of life then existing, and of the circumstances which determined or affected them; while words are as rolled pebbles, relics of yet more ancient formations, or as fossils, whose grade indicates the progress of organic life, and whose resemblances and relations show the correspondence or sequence of the different strata; while, everywhere, extensive denudation has marred the completeness of the record, and rendered impossible a detailed exhibition of the whole course of development.

A parable: A man was examining the construction of a cathedral. He asked a stone mason what he was doing chipping the stones, and the mason replied, “I am making stones.” He asked a stone carver what he was doing. “I am carving a gargoyle.” And so it went, each person said in detail what they were doing. Finally he came to an old woman who was sweeping the ground. She said. “I am helping build a cathedral.”
...Most of the time each person is immersed in the details of one special part of the whole and does not think of how what they are doing relates to the larger picture.
[For example, in education, a teacher might say in the next class he was going to “explain Young's modulus and how to measure it,” rather than, “I am going to educate the students and prepare them for their future careers.”]

A pawn is the most important piece on the chessboard—to a pawn.

A peacetime draft is the most un-American thing I know.

A person filled with gumption doesn’t sit about stewing about things. He’s at the front of the train of his own awareness, watching to see what’s up the track and meeting it when it comes. That’s gumption. If you’re going to repair a motorcycle, an adequate supply of gumption is the first and most important tool. If you haven’t got that you might as well gather up all the other tools and put them away, because they won’t do you any good.

A physician’s subject of study is necessarily the patient, and his first field for observation is the hospital. But if clinical observation teaches him to know the form and course of diseases, it cannot suffice to make him understand their nature; to this end he must penetrate into the body to find which of the internal parts are injured in their functions. That is why dissection of cadavers and microscopic study of diseases were soon added to clinical observation. But to-day these various methods no longer suffice; we must push investigation further and, in analyzing the elementary phenomena of organic bodies, must compare normal with abnormal states. We showed elsewhere how incapable is anatomy alone to take account of vital phenenoma, and we saw that we must add study of all physico-chemical conditions which contribute necessary elements to normal or pathological manifestations of life. This simple suggestion already makes us feel that the laboratory of a physiologist-physician must be the most complicated of all laboratories, because he has to experiment with phenomena of life which are the most complex of all natural phenomena.

A railroad may have to be carried over a gorge or arroya. Obviously it does not need an Engineer to point out that this may be done by filling the chasm with earth, but only a Bridge Engineer is competent to determine whether it is cheaper to do this or to bridge it, and to design the bridge which will safely and most cheaply serve.

A science in its infancy is the least satisfactory, and, at the same time, the most profitable theme for a general description.

A vast technology has been developed to prevent, reduce, or terminate exhausting labor and physical damage. It is now dedicated to the production of the most trivial conveniences and comfort.

A vision of the whole of life!. Could any human undertaking be ... more grandiose? This attempt stands without rival as the most audacious enterprise in which the mind of man has ever engaged ... Here is man, surrounded by the vastness of a universe in which he is only a tiny and perhaps insignificant part—and he wants to understand it.

A wonder then it must needs be,—that there should be any Man found so stupid and forsaken of reason as to persuade himself, that this most beautiful and adorned world was or could be produced by the fortuitous concourse of atoms.

About eight days ago I discovered that sulfur in burning, far from losing weight, on the contrary, gains it; it is the same with phosphorus; this increase of weight arises from a prodigious quantity of air that is fixed during combustion and combines with the vapors. This discovery, which I have established by experiments, that I regard as decisive, has led me to think that what is observed in the combustion of sulfur and phosphorus may well take place in the case of all substances that gain in weight by combustion and calcination; and I am persuaded that the increase in weight of metallic calxes is due to the same cause... This discovery seems to me one of the most interesting that has been made since Stahl and since it is difficult not to disclose something inadvertently in conversation with friends that could lead to the truth I have thought it necessary to make the present deposit to the Secretary of the Academy to await the time I make my experiments public.

Abstract as it is, science is but an outgrowth of life. That is what the teacher must continually keep in mind. … Let him explain … science is not a dead system—the excretion of a monstrous pedantism—but really one of the most vigorous and exuberant phases of human life.

Abstruse mathematical researches … are … often abused for having no obvious physical application. The fact is that the most useful parts of science have been investigated for the sake of truth, and not for their usefulness. A new branch of mathematics, which has sprung up in the last twenty years, was denounced by the Astronomer Royal before the University of Cambridge as doomed to be forgotten, on account of its uselessness. Now it turns out that the reason why we cannot go further in our investigations of molecular action is that we do not know enough of this branch of mathematics.

After Gibbs, one the most distinguished [American scientists] was Langley, of the Smithsonian. … He had the physicist’s heinous fault of professing to know nothing between flashes of intense perception. … Rigidly denying himself the amusement of philosophy, which consists chiefly in suggesting unintelligible answers to insoluble problems, and liked to wander past them in a courteous temper, even bowing to them distantly as though recognizing their existence, while doubting their respectability.

Again and again in reading even his [William Thomson] most abstract writings one is struck by the tenacity with which physical ideas control in him the mathematical form in which he expressed them. An instance of this is afforded by … an example of a mathematical result that is, in his own words, “not instantly obvious from the analytical form of my solution, but which we immediately see must be the case by thinking of the physical meaning of the result.”

Alchymy, or Chymistry, is …
An Art which good men bate, and most men blame,
Which her admirers practice to their shame,
Whose plain Impostures, easie to perceive,
Not onely others, but themselves deceive.

All admit that the mountains of the globe are situated mostly along the border regions of the continents (taking these regions as 300 to 1000 miles or more in width), and that over these same areas the sedimentary deposits have, as a general thing, their greatest thickness. At first thought, it would seem almost incredible that the upliftings of mountains, whatever their mode of origin, should have taken place just where the earth’s crust, through these sedimentary accumulations, was the thickest, and where, therefore, there was the greatest weight to be lifted. … Earthquakes show that even now, in this last of the geological ages, the same border regions of the continents, although daily thickening from the sediments borne to the ocean by rivers, are the areas of the greatest and most frequent movements of the earth’s crust. (1866)
[Thus, the facts were known long ago; the explanation by tectonic activity came many decades later.]

All fossil anthropoids found hitherto have been known only from mandibular or maxillary fragments, so far as crania are concerned, and so the general appearance of the types they represented had been unknown; consequently, a condition of affairs where virtually the whole face and lower jaw, replete with teeth, together with the major portion of the brain pattern, have been preserved, constitutes a specimen of unusual value in fossil anthropoid discovery. Here, as in Homo rhodesiensis, Southern Africa has provided documents of higher primate evolution that are amongst the most complete extant. Apart from this evidential completeness, the specimen is of importance because it exhibits an extinct race of apes intermediate between living anthropoids and man ... Whether our present fossil is to be correlated with the discoveries made in India is not yet apparent; that question can only be solved by a careful comparison of the permanent molar teeth from both localities. It is obvious, meanwhile, that it represents a fossil group distinctly advanced beyond living anthropoids in those two dominantly human characters of facial and dental recession on one hand, and improved quality of the brain on the other. Unlike Pithecanthropus, it does not represent an ape-like man, a caricature of precocious hominid failure, but a creature well advanced beyond modern anthropoids in just those characters, facial and cerebral, which are to be anticipated in an extinct link between man and his simian ancestor. At the same time, it is equally evident that a creature with anthropoid brain capacity and lacking the distinctive, localised temporal expansions which appear to be concomitant with and necessary to articulate man, is no true man. It is therefore logically regarded as a man-like ape. I propose tentatively, then, that a new family of Homo-simidæ be created for the reception of the group of individuals which it represents, and that the first known species of the group be designated Australopithecus africanus, in commemoration, first, of the extreme southern and unexpected horizon of its discovery, and secondly, of the continent in which so many new and important discoveries connected with the early history of man have recently been made, thus vindicating the Darwinian claim that Africa would prove to be the cradle of mankind.

All good intellects have repeated, since Bacon’s time, that there can be no real knowledge but that which is based on observed facts. This is incontestable, in our present advanced stage; but, if we look back to the primitive stage of human knowledge, we shall see that it must have been otherwise then. If it is true that every theory must be based upon observed facts, it is equally true that facts cannot be observed without the guidance of some theory. Without such guidance, our facts would be desultory and fruitless; we could not retain them: for the most part we could not even perceive them.

All historians, even the most scientific, have bias, if in no other sense than the determination not to have any.