... in going over the history of all the inventions for which history could be obtained it became more and more clear that in addition to training and in addition to extensive knowledge, a natural quality of mind was also necessary.

’Tis evident, that as common Air when reduc’d to half Its wonted extent, obtained near about twice as forcible a Spring as it had before; so this thus- comprest Air being further thrust into half this narrow room, obtained thereby a Spring about as strong again as that It last had, and consequently four times as strong as that of the common Air. And there is no cause to doubt, that If we had been here furnisht with a greater quantity of Quicksilver and a very long Tube, we might by a further compression of the included Air have made It counter-balance “the pressure” of a far taller and heavier Cylinder of Mercury. For no man perhaps yet knows how near to an infinite compression the Air may be capable of, If the compressing force be competently increast.

[Louis Rendu, Bishop of Annecy] collects observations, makes experiments, and tries to obtain numerical results; always taking care, however, so to state his premises and qualify his conclusions that nobody shall be led to ascribe to his numbers a greater accuracy than they merit. It is impossible to read his work, and not feel that he was a man of essentially truthful mind and that science missed an ornament when he was appropriated by the Church.

[Modern science] passed through a long period of uncertainty and inconclusive experiment, but as the instrumental aids to research improved, and the results of observation accumulated, phantoms of the imagination were exorcised, idols of the cave were shattered, trustworthy materials were obtained for logical treatment, and hypotheses by long and careful trial were converted into theories.

[On the use of scopolamine in criminology], If it is permissible for a state to take life, liberty and property because of crime, it can be made legal to obtain information from a suspected criminal by the use of a drug. If the use of bloodhounds is legal, the use of scopolamine can be made legal.

A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here.

A moment’s consideration of this case shows what a really great advance in the theory and practise of breeding has been obtained through the discovery of Mendel’s law. What a puzzle this case would have presented to the biologist ten years ago! Agouti crossed with chocolate gives in the second filial generation (not in the first) four varieties, viz., agouti, chocolate, black and cinnamon. We could only have shaken our heads and looked wise (or skeptical).
Then we had no explanation to offer for such occurrences other than the “instability of color characters under domestication,” the “effects of inbreeding,” “maternal impressions.” Serious consideration would have been given to the proximity of cages containing both black and cinnamon-agouti mice.
Now we have a simple, rational explanation, which anyone can put to the test. We are able to predict the production of new varieties, and to produce them.
We must not, of course, in our exuberance, conclude that the powers of the hybridizer know no limits. The result under consideration consists, after all, only in the making of new combinations of unit characters, but it is much to know that these units exist and that all conceivable combinations of them are ordinarily capable of production. This valuable knowledge we owe to the discoverer and to the rediscoverers of Mendel’s law.

A single tree by itself is dependent upon all the adverse chances of shifting circumstances. The wind stunts it: the variations in temperature check its foliage: the rains denude its soil: its leaves are blown away and are lost for the purpose of fertilisation. You may obtain individual specimens of line trees either in exceptional circumstances, or where human cultivation had intervened. But in nature the normal way in which trees flourish is by their association in a forest. Each tree may lose something of its individual perfection of growth, but they mutually assist each other in preserving the conditions of survival. The soil is preserved and shaded; and the microbes necessary for its fertility are neither scorched, nor frozen, nor washed away. A forest is the triumph of the organisation of mutually dependent species.

A truer image of the world, I think, is obtained by picturing things as entering into the stream of time from an eternal world outside, than from a view which regards time as the devouring tyrant of all that is.

Abraham Maslow, felt … [an] instinctive revolt against the “atmosphere” of Freudian psychology, with its emphasis on sickness and neurosis, and decided that he might obtain some equally interesting results if he studied extremely healthy people.

All that we can hope from these inspirations, which are the fruits of unconscious work, is to obtain points of departure for such calculations. As for the calculations themselves, they must be made in the second period of conscious work which follows the inspiration, and in which the results of the inspiration are verified and the consequences deduced.

Analyse data just so far as to obtain simplicity and no further.

Anyone who has had actual contact with the making of the inventions that built the radio art knows that these inventions have been the product of experiment and work based on physical reasoning, rather than on the mathematicians' calculations and formulae. Precisely the opposite impression is obtained from many of our present day text books and publications.

Archimedes possessed so high a spirit, so profound a soul, and such treasures of highly scientific knowledge, that though these inventions [used to defend Syracuse against the Romans] had now obtained him the renown of more than human sagacity, he yet would not deign to leave behind him any commentary or writing on such subjects; but, repudiating as sordid and ignoble the whole trade of engineering, and every sort of art that lends itself to mere use and profit, he placed his whole affection and ambition in those purer speculations where there can be no reference to the vulgar needs of life; studies, the superiority of which to all others is unquestioned, and in which the only doubt can be whether the beauty and grandeur of the subjects examined, or the precision and cogency of the methods and means of proof, most deserve our admiration.

As a progressive discipline [biochemistry] belongs to the present century. From the experimental physiologists of the last century it obtained a charter, and, from a few pioneers of its own, a promise of success; but for the furtherance of its essential aim that century left it but a small inheritance of facts and methods. By its essential or ultimate aim I myself mean an adequate and acceptable description of molecular dynamics in living cells and tissues.

As an antiquary of a new order, I have been obliged to learn the art of deciphering and restoring these remains, of discovering and bringing together, in their primitive arrangement, the scattered and mutilated fragments of which they are composed, of reproducing in all their original proportions and characters, the animals to which these fragments formerly belonged, and then of comparing them with those animals which still live on the surface of the earth; an art which is almost unknown, and which presupposes, what had scarcely been obtained before, an acquaintance with those laws which regulate the coexistence of the forms by which the different parts of organized being are distinguished.

At the entrance to the observatory Stjerneborg located underground, Tycho Brahe built a Ionic portal. On top of this were three sculptured lions. On both sides were inscriptions and on the backside was a longer inscription in gold letters on a porfyr stone: Consecrated to the all-good, great God and Posterity. Tycho Brahe, Son of Otto, who realized that Astronomy, the oldest and most distinguished of all sciences, had indeed been studied for a long time and to a great extent, but still had not obtained sufficient firmness or had been purified of errors, in order to reform it and raise it to perfection, invented and with incredible labour, industry, and expenditure constructed various exact instruments suitable for all kinds of observations of the celestial bodies, and placed them partly in the neighbouring castle of Uraniborg, which was built for the same purpose, partly in these subterranean rooms for a more constant and useful application, and recommending, hallowing, and consecrating this very rare and costly treasure to you, you glorious Posterity, who will live for ever and ever, he, who has both begun and finished everything on this island, after erecting this monument, beseeches and adjures you that in honour of the eternal God, creator of the wonderful clockwork of the heavens, and for the propagation of the divine science and for the celebrity of the fatherland, you will constantly preserve it and not let it decay with old age or any other injury or be removed to any other place or in any way be molested, if for no other reason, at any rate out of reverence to the creator’s eye, which watches over the universe. Greetings to you who read this and act accordingly. Farewell!

Attempts have been made from a study of the changes produced by mutation to obtain the relative order of the bases within various triplets, but my own view is that these are premature until there is more extensive and more reliable data on the composition of the triplets.

Besides accustoming the student to demand, complete proof, and to know when he has not obtained it, mathematical studies are of immense benefit to his education by habituating him to precision. It is one of the peculiar excellencies of mathematical discipline, that the mathematician is never satisfied with à peu près. He requires the exact truth. Hardly any of the non-mathematical sciences, except chemistry, has this advantage. One of the commonest modes of loose thought, and sources of error both in opinion and in practice, is to overlook the importance of quantities. Mathematicians and chemists are taught by the whole course of their studies, that the most fundamental difference of quality depends on some very slight difference in proportional quantity; and that from the qualities of the influencing elements, without careful attention to their quantities, false expectation would constantly be formed as to the very nature and essential character of the result produced.

Beware of the problem of testing too many hypotheses; the more you torture the data, the more likely they are to confess, but confessions obtained under duress may not be admissible in the court of scientific opinion.

But although in theory physicists realize that their conclusions are ... not certainly true, this ... does not really sink into their consciousness. Nearly all the time ... they ... act as if Science were indisputably True, and what's more, as if only science were true.... Any information obtained otherwise than by the scientific method, although it may be true, the scientists will call “unscientific,” using this word as a smear word, by bringing in the connotation from its original [Greek] meaning, to imply that the information is false, or at any rate slightly phony.

But we shall not satisfy ourselves simply with improving steam and explosive engines or inventing new batteries; we have something much better to work for, a greater task to fulfill. We have to evolve means for obtaining energy from stores which are forever inexhaustible, to perfect methods which do not imply consumption and waste of any material whatever.

Cayley was singularly learned in the work of other men, and catholic in his range of knowledge. Yet he did not read a memoir completely through: his custom was to read only so much as would enable him to grasp the meaning of the symbols and understand its scope. The main result would then become to him a subject of investigation: he would establish it (or test it) by algebraic analysis and, not infrequently, develop it so to obtain other results. This faculty of grasping and testing rapidly the work of others, together with his great knowledge, made him an invaluable referee; his services in this capacity were used through a long series of years by a number of societies to which he was almost in the position of standing mathematical advisor.

Chemistry is not a primitive science like geometry and astronomy; it is constructed from the debris of a previous scientific formation; a formation half chimerical and half positive, itself found on the treasure slowly amassed by the practical discoveries of metallurgy, medicine, industry and domestic economy. It has to do with alchemy, which pretended to enrich its adepts by teaching them to manufacture gold and silver, to shield them from diseases by the preparation of the panacea, and, finally, to obtain for them perfect felicity by identifying them with the soul of the world and the universal spirit.

Classes and concepts may, however, also be conceived as real objects, namely classes as “pluralities of things” or as structures consisting of a plurality of things and concepts as the properties and relations of things existing independently of our definitions and constructions. It seems to me that the assumption of such objects is quite as legitimate as the assumption of physical bodies and there is quite as much reason to believe in their existence. They are in the same sense necessary to obtain a satisfactory system of mathematics as physical bodies are necessary for a satisfactory theory of our sense perceptions…

Curves that have no tangents are the rule. … Those who hear of curves without tangents, or of functions without derivatives, often think at first that Nature presents no such complications. … The contrary however is true. … Consider, for instance, one of the white flakes that are obtained by salting a solution of soap. At a distance its contour may appear sharply defined, but as we draw nearer its sharpness disappears. The eye can no longer draw a tangent at any point. … The use of a magnifying glass or microscope leaves us just as uncertain, for fresh irregularities appear every time we increase the magnification. … An essential characteristic of our flake … is that we suspect … that any scale involves details that absolutely prohibit the fixing of a tangent.

During the time of the Deluge, whilst the Water was out upon, and covered the Terrestrial Globe, … all Fossils whatever that had before obtained any Solidity, were totally dissolved, and their constituent Corpuscles all disjoyned, their Cohesion perfectly ceasing … [A]nd, to be short, all Bodies whatsoever that were either upon the Earth, or that constituted the Mass of it, if not quite down to the Abyss, yet at least to the greatest depth we ever dig: I say all these were assumed up promiscuously into the Water, and sustained in it, in such a manner that the Water, and Bodies in it, together made up one common confused Mass. That at length all the Mass that was thus borne up in the Water, was again precipitated and subsided towards the bottom. That this subsidence happened generally, and as near as possibly could be expected in so great a Confusion, according to the laws of Gravity.

Each species has evolved a special set of solutions to the general problems that all organisms must face. By the fact of its existence, a species demonstrates that its members are able to carry out adequately a series of general functions. … These general functions offer a framework within which one can integrate one’s view of biology and focus one’s research. Such a view helps one to avoid becoming lost in a morass of unstructured detail—even though the ways in which different species perform these functions may differ widely. A few obvious examples will suffice. Organisms must remain functionally integrated. They must obtain materials from their environments, and process and release energy from these materials. … They must differentiate and grow, and they must reproduce. By focusing one’s questions on one or another of these obligatory and universal capacities, one can ensure that one’s research will not be trivial and that it will have some chance of achieving broad general applicability.

Edison was by far the most successful and, probably, the last exponent of the purely empirical method of investigation. Everything he achieved was the result of persistent trials and experiments often performed at random but always attesting extraordinary vigor and resource. Starting from a few known elements, he would make their combinations and permutations, tabulate them and run through the whole list, completing test after test with incredible rapidity until he obtained a clue. His mind was dominated by one idea, to leave no stone unturned, to exhaust every possibility.

Endowed with two qualities, which seemed incompatible with each other, a volcanic imagination and a pertinacity of intellect which the most tedious numerical calculations could not daunt, Kepler conjectured that the movements of the celestial bodies must be connected together by simple laws, or, to use his own expression, by harmonic laws. These laws he undertook to discover. A thousand fruitless attempts, errors of calculation inseparable from a colossal undertaking, did not prevent him a single instant from advancing resolutely toward the goal of which he imagined he had obtained a glimpse. Twenty-two years were employed by him in this investigation, and still he was not weary of it! What, in reality, are twenty-two years of labor to him who is about to become the legislator of worlds; who shall inscribe his name in ineffaceable characters upon the frontispiece of an immortal code; who shall be able to exclaim in dithyrambic language, and without incurring the reproach of anyone, “The die is cast; I have written my book; it will be read either in the present age or by posterity, it matters not which; it may well await a reader, since God has waited six thousand years for an interpreter of his words.”

Euclid avoids it [the treatment of the infinite]; in modern mathematics it is systematically introduced, for only then is generality obtained.

Even fairly good students, when they have obtained the solution of the problem and written down neatly the argument, shut their books and look for something else. Doing so, they miss an important and instructive phase of the work. ... A good teacher should understand and impress on his students the view that no problem whatever is completely exhausted.

Experiments may be of two kinds: experiments of simple fact, and experiments of quantity. ...[In the latter] the conditions will ... vary, not in quality, but quantity, and the effect will also vary in quantity, so that the result of quantitative induction is also to arrive at some mathematical expression involving the quantity of each condition, and expressing the quantity of the result. In other words, we wish to know what function the effect is of its conditions. We shall find that it is one thing to obtain the numerical results, and quite another thing to detect the law obeyed by those results, the latter being an operation of an inverse and tentative character.

Fertilization of mammalian eggs is followed by successive cell divisions and progressive differentiation, first into the early embryo and subsequently into all of the cell types that make up the adult animal. Transfer of a single nucleus at a specific stage of development, to an enucleated unfertilized egg, provided an opportunity to investigate whether cellular differentiation to that stage involved irreversible genetic modification. The first offspring to develop from a differentiated cell were born after nuclear transfer from an embryo-derived cell line that had been induced to became quiescent. Using the same procedure, we now report the birth of live lambs from three new cell populations established from adult mammary gland, fetus and embryo. The fact that a lamb was derived from an adult cell confirms that differentiation of that cell did not involve the irreversible modification of genetic material required far development to term. The birth of lambs from differentiated fetal and adult cells also reinforces previous speculation that by inducing donor cells to became quiescent it will be possible to obtain normal development from a wide variety of differentiated cells.
[Co-author of paper announcing the cloned sheep, ‘Dolly’.]

Food is at present obtained almost entirely from the energy of the sunlight. The radiation from the sun produces from the carbonic acid in the air more or less complicated carbon compounds which serve us in plants and vegetables. We use the latent chemical energy of these to keep our bodies warm, we convert it into muscular effort. We employ it in the complicated process of digestion to repair and replace the wasted cells of our bodies. … If the gigantic sources of power become available, food would be produced without recourse to sunlight. Vast cellars, in which artificial radiation is generated, may replace the cornfields and potato patches of the world.

Forests and trees make significant direct contributions to the nutrition of poor households ... [as] rural communities in Central Africa obtained a critical portion of protein and fat in their diets through hunting wildlife from in and around forests. The five to six million tonnes of bushmeat eaten yearly in the Congo Basin is roughly equal to the total amount of beef produced annually in Brazil – without the accompanying need to clear huge swathes of forest for cattle.

From common salt are obtained chemically as primary derivatives chlorine—both a war gas and a means of purifying water; and 'caustic soda.' … [O]n the chlorine side there is obtained chloride of lime, (a bleaching powder and a disinfectant), chloroform (an anesthetic), phosgene (a frightful ware gas), chloroacetophenone (another war gas), and an indigo and a yellow dye. [O]n the soda side we get metallic sodium, from which are derived sodium cyanide (a disinfectant), two medicines with [long] names, another war gas, and a beautiful violet dye. Thus, from a healthful, preservative condiment come things useful and hurtful—according to the intent or purpose.

From the sexual, or amatorial, generation of plants new varieties, or improvements, are frequently obtained; as many of the young plants from seeds are dissimilar to the parent, and some of them superior to the parent in the qualities we wish to possess... Sexual reproduction is the chef d'oeuvre, the master-piece of nature.

Geology is intimately related to almost all the physical sciences, as is history to the moral. An historian should, if possible, be at once profoundly acquainted with ethics, politics, jurisprudence, the military art, theology; in a word, with all branches of knowledge, whereby any insight into human affairs, or into the moral and intellectual nature of man, can be obtained. It would be no less desirable that a geologist should be well versed in chemistry, natural philosophy, mineralogy, zoology, comparative anatomy, botany; in short, in every science relating to organic and inorganic nature. With these accomplishments the historian and geologist would rarely fail to draw correct and philosophical conclusions from the various monuments transmitted to them of former occurrences.

Goethe said that he who cannot draw on 3,000 years of learning is living hand to mouth. It could just as well be said that individuals who do tap deeply into this rich cultural legacy are wealthy indeed. Yet the paradox is that much of this wisdom is buried in a sea of lesser books or like lost treasure beneath an ocean of online ignorance and trivia. That doesn’t mean that with a little bit of diligence you can’t tap into it. Yet many people, perhaps most, never take advantage of all this human experience. They aren’t obtaining knowledge beyond what they need to know for work or to get by. As a result, their view of our amazing world is diminished and their lives greatly circumscribed.

He that desireth to acquire any art or science seeketh first those means by which that art or science is obtained.

He who thus considers things in their first growth and origin … will obtain the clearest view of them.

Here and elsewhere we shall not obtain the best insight into things until we actually see them growing from the beginning.

I am delighted that I have found a new reaction to demonstrate even to the blind the structure of the interstitial stroma of the cerebral cortex. I let the silver nitrate react with pieces of brain hardened in potassium dichromate. I have already obtained magnificent results and hope to do even better in the future.

I ask any one who has adopted the calling of an engineer, how much time he lost when he left school, because he had to devote himself to pursuits which were absolutely novel and strange, and of which he had not obtained the remotest conception from his instructors? He had to familiarize himself with ideas of the course and powers of Nature, to which his attention had never been directed during his school-life, and to learn, for the first time, that a world of facts lies outside and beyond the world of words.

I do not believe that the present flowering of science is due in the least to a real appreciation of the beauty and intellectual discipline of the subject. It is due simply to the fact that power, wealth and prestige can only be obtained by the correct application of science.

I do not hope for any relief, and that is because I have committed no crime. I might hope for and obtain pardon, if I had erred, for it is to faults that the prince can bring indulgence, whereas against one wrongfully sentenced while he was innocent, it is expedient, in order to put up a show of strict lawfulness, to uphold rigor… . But my most holy intention, how clearly would it appear if some power would bring to light the slanders, frauds, and stratagems, and trickeries that were used eighteen years ago in Rome in order to deceive the authorities!

I do not know if I am mistaken, but it seems that one can obtain more truths, important to Humanity, from Chemistry than from any other Science.

I doubt that Fleming could have obtained a grant for the discovery of penicillin on that basis [a requirement for highly detailed research plans] because he could not have said, 'I propose to have an accident in a culture so that it will be spoiled by a mould falling on it, and I propose to recognize the possibility of extracting an antibiotic from this mould.'

I have learnt that all our theories are not Truth itself, but resting places or stages on the way to the conquest of Truth, and that we must be contented to have obtained for the strivers after Truth such a resting place which, if it is on a mountain, permits us to view the provinces already won and those still to be conquered.

I have never thought that you could obtain the extremely clumpy, heterogeneous universe we have today, strongly affected by plasma processes, from the smooth, homogeneous one of the Big Bang, dominated by gravitation.

I have reviewed this work elsewhere under the title 'Natural Products Chemistry 1950 to 1980-A Personal View.' It is with some relish that I recall the flood of reprint requests prompted by the following footnote on the title page: 'Selected personal statements by the author were removed by the editor without Professor Djerassi's consent. An uncensored version of this paper can be obtained by writing to Professor C. Djerassi'.

I resolved to obtain from myself [through automatic writing] what we were trying to obtain from them, namely a monologue spoken as rapidly as possible without any intervention on the part of the critical faculties, a monologue consequently unencumbered by the slightest inhibition and which was, as closely as possible akin to spoken thought. It had seemed to me, and still does … that the speed of thought does not necessarily defy language, nor even the fast-moving pen.

I think equation guessing might be the best method to proceed to obtain the laws for the part of physics which is presently unknown.

I venture to maintain, that, if the general culture obtained in the Faculty of Arts were what it ought to be, the student would have quite as much knowledge of the fundamental principles of Physics, of Chemistry, and of Biology, as he needs, before he commenced his special medical studies. Moreover, I would urge, that a thorough study of Human Physiology is, in itself, an education broader and more comprehensive than much that passes under that name. There is no side of the intellect which it does not call into play, no region of human knowledge into which either its roots, or its branches, do not extend; like the Atlantic between the Old and the New Worlds, its waves wash the shores of the two worlds of matter and of mind; its tributary streams flow from both; through its waters, as yet unfurrowed by the keel of any Columbus, lies the road, if such there be, from the one to the other; far away from that Northwest Passage of mere speculation, in which so many brave souls have been hopelessly frozen up.

I was fascinated by fractional distillation as a method while still a school-boy, and built in the cellar of my home, which was my combined workshop and laboratory, distillation columns, packed with coke of graded size, some five feet in height. They were made from coffee tins (obtained from the kitchen), with the bottoms removed and soldered together! Experience with them served me in good stead and by the time I graduated I had a good understanding of the problems of fractional distillation.

If all the elements are arranged in the order of their atomic weights, a periodic repetition of properties is obtained. This is expressed by the law of periodicity.

If we ascribe the ejection of the proton to a Compton recoil from a quantum of 52 x 10⁶ electron volts, then the nitrogen recoil atom arising by a similar process should have an energy not greater than about 400,000 volts, should produce not more than about 10,000 ions, and have a range in the air at N.T.P. of about 1-3mm. Actually, some of the recoil atoms in nitrogen produce at least 30,000 ions. In collaboration with Dr. Feather, I have observed the recoil atoms in an expansion chamber, and their range, estimated visually, was sometimes as much as 3mm. at N.T.P.
These results, and others I have obtained in the course of the work, are very difficult to explain on the assumption that the radiation from beryllium is a quantum radiation, if energy and momentum are to be conserved in the collisions. The difficulties disappear, however, if it be assumed that the radiation consists of particles of mass 1 and charge 0, or neutrons. The capture of the a-particle by the Be⁹ nucleus may be supposed to result in the formation of a C¹² nucleus and the emission of the neutron. From the energy relations of this process the velocity of the neutron emitted in the forward direction may well be about 3 x 10⁹ cm. per sec. The collisions of this neutron with the atoms through which it passes give rise to the recoil atoms, and the observed energies of the recoil atoms are in fair agreement with this view. Moreover, I have observed that the protons ejected from hydrogen by the radiation emitted in the opposite direction to that of the exciting a-particle appear to have a much smaller range than those ejected by the forward radiation.
This again receives a simple explanation on the neutron hypothesis.

If we work, it is less to obtain those positive results the common people think are our only interest, than to feel that aesthetic emotion and communicate it to those able to experience it.

In early life I had felt a strong desire to devote myself to the experimental study of nature; and, happening to see a glass containing some camphor, portions of which had been caused to condense in very beautiful crystals on the illuminated side, I was induced to read everything I could obtain respecting the chemical and mechanical influences of light, adhesion, and capillary attraction.

In Euclid each proposition stands by itself; its connection with others is never indicated; the leading ideas contained in its proof are not stated; general principles do not exist. In modern methods, on the other hand, the greatest importance is attached to the leading thoughts which pervade the whole; and general principles, which bring whole groups of theorems under one aspect, are given rather than separate propositions. The whole tendency is toward generalization. A straight line is considered as given in its entirety, extending both ways to infinity, while Euclid is very careful never to admit anything but finite quantities. The treatment of the infinite is in fact another fundamental difference between the two methods. Euclid avoids it, in modern mathematics it is systematically introduced, for only thus is generality obtained.

In history an additional result is commonly produced by human actions beyond that which they aim at and obtain—that which they immediately recognize and desire. They gratify their own interest; but something further is thereby accomplished, latent in the actions in question, though not present to their consciousness, and not included in their design. … This may be called the cunning of reason.

In my youth I often asked what could be the use and necessity of smelting by putting powdered charcoal at the bottom of the furnace. Nobody could give me any other reason except that the metal and especially lead, could bury itself in the charcoal and so be protected against the action of the bellows which would calcine or dissipate it. Nevertheless it is evident that this does not answer the question. I accordingly examined the operation of a metallurgical furnace and how it was used. In assaying some litharge [lead oxide], I noticed each time a little charcoal fell into the crucible, I always obtained a bit of lead … I do not think up to the present time foundry-men ever surmised that in the operation of founding with charcoal there was something [phlogiston] which became corporeally united with the metal.

In order that the facts obtained by observation and experiment may be capable of being used in furtherance of our exact and solid knowledge, they must be apprehended and analysed according to some Conceptions which, applied for this purpose, give distinct and definite results, such as can be steadily taken hold of and reasoned from.

In the animal world we have seen that the vast majority of species live in societies, and that they find in association the best arms for the struggle for life: understood, of course, in its wide Darwinian sense—not as a struggle for the sheer means of existence, but as a struggle against all natural conditions unfavourable to the species. The animal species, in which individual struggle has been reduced to its narrowest limits, and the practice of mutual aid has attained the greatest development, are invariably the most numerous, the most prosperous, and the most open to further progress. The mutual protection which is obtained in this case, the possibility of attaining old age and of accumulating experience, the higher intellectual development, and the further growth of sociable habits, secure the maintenance of the species, its extension, and its further progressive evolution. The unsociable species, on the contrary, are doomed to decay.

In the collecting of evidence upon any medical subject, there are but three sources from which we can hope to obtain it: viz. from observation of the living subject; from examination of the dead; and from experiments upon living animals.

In the discovery of hidden things and the investigation of hidden causes, stronger reasons are obtained from sure experiments and demonstrated arguments than from probable conjectures and the opinions of philosophical speculators of the common sort...

In the discovery of lemmas the best aid is a mental aptitude for it. For we may see many who are quick at solutions and yet do not work by method ; thus Cratistus in our time was able to obtain the required result from first principles, and those the fewest possible, but it was his natural gift which helped him to the discovery.

In working out physical problems there should be, in the first place, no pretence of rigorous formalism. The physics will guide the physicist along somehow to useful and important results, by the constant union of physical and geometrical or analytical ideas. The practice of eliminating the physics by reducing a problem to a purely mathematical exercise should be avoided as much as possible. The physics should be carried on right through, to give life and reality to the problem, and to obtain the great assistance which the physics gives to the mathematics.

Inductive reasoning is, of course, good guessing, not sound reasoning, but the finest results in science have been obtained in this way. Calling the guess a “working hypothesis,” its consequences are tested by experiment in every conceivable way.

Inventions and discoveries are of two kinds. The one which we owe to chance, such as those of the mariner’s compass, gunpowder, and in general almost all the discoveries we have made in the arts. The other which we owe to genius: and here we ought to understand by the word discovery, a new combination, or a new relation perceived between certain objects or ideas. A person obtains the title of a man of genius, if the ideas which result from this combination form one grand whole, are fruitful in truths, and are of importance with respect to mankind.

It always seems to be easier to obtain financial support for science when there is some connection with defence. Oceanography is no exception to this.

It is admitted by all that a finished or even a competent reasoner is not the work of nature alone; the experience of every day makes it evident that education develops faculties which would otherwise never have manifested their existence. It is, therefore, as necessary to learn to reason before we can expect to be able to reason, as it is to learn to swim or fence, in order to attain either of those arts. Now, something must be reasoned upon, it matters not much what it is, provided it can be reasoned upon with certainty. The properties of mind or matter, or the study of languages, mathematics, or natural history, may be chosen for this purpose. Now of all these, it is desirable to choose the one which admits of the reasoning being verified, that is, in which we can find out by other means, such as measurement and ocular demonstration of all sorts, whether the results are true or not. When the guiding property of the loadstone was first ascertained, and it was necessary to learn how to use this new discovery, and to find out how far it might be relied on, it would have been thought advisable to make many passages between ports that were well known before attempting a voyage of discovery. So it is with our reasoning faculties: it is desirable that their powers should be exerted upon objects of such a nature, that we can tell by other means whether the results which we obtain are true or false, and this before it is safe to trust entirely to reason. Now the mathematics are peculiarly well adapted for this purpose, on the following grounds:
1. Every term is distinctly explained, and has but one meaning, and it is rarely that two words are employed to mean the same thing.
2. The first principles are self-evident, and, though derived from observation, do not require more of it than has been made by children in general.
3. The demonstration is strictly logical, taking nothing for granted except self-evident first principles, resting nothing upon probability, and entirely independent of authority and opinion.
4. When the conclusion is obtained by reasoning, its truth or falsehood can be ascertained, in geometry by actual measurement, in algebra by common arithmetical calculation. This gives confidence, and is absolutely necessary, if, as was said before, reason is not to be the instructor, but the pupil.
5. There are no words whose meanings are so much alike that the ideas which they stand for may be confounded. Between the meaning of terms there is no distinction, except a total distinction, and all adjectives and adverbs expressing difference of degrees are avoided.

It is clear that in maize, seemingly blending is really segregating inheritance, but with entire absence of dominance, and it seems probably that the same will be found to be true among rabbits and other mammals; failure to observe it hitherto is probably due to the fact that the factors concerned are numerous. For the greater the number of factors concerned, the more nearly will the result obtained approximate a complete and permanent blend. As the number of factors approaches infinity, the result will become identical with a permanent blend.

It is distinctly proved, by this series of observations, that the reflex function exists in the medulla independently of the brain; in the medulla oblongata independently of the medulla spinalis; and in the spinal marrow of the anterior extremities, of the posterior extremities, and of the tail, independently of that of each other of these parts, respectively. There is still a more interesting and satisfactory mode of performing the experiment: it is to divide the spinal marrow between the nerves of the superior and inferior extremities. We have then two modes of animal life : the first being the assemblage of the voluntary and respiratory powers with those of the reflex function and irritability; the second, the two latter powers only: the first are those which obtain in the perfect animal, the second those which animate the foetus. The phenomena are precisely what might have been anticipated. If the spinal marrow be now destroyed, the irritability alone remains,—all the other phenomena having ceased.

It is easy to obtain confirmations, or verifications, for nearly every theory—if we look for confirmations. Confirmations should count only if they are the result of risky predictions... A theory which is not refutable by any conceivable event is non-scientific. Irrefutability is not a virtue of a theory (as people often think) but a vice. Every genuine test of a theory is an attempt to falsify it, or refute it.

It is often in our Power to obtain an Analogy where we cannot have an Induction.

It is the triumph of civilization that at last communities have obtained such a mastery over natural laws that they drive and control them. The winds, the water, electricity, all aliens that in their wild form were dangerous, are now controlled by human will, and are made useful servants.

It often happens that men, even of the best understandings and greatest circumspection, are guilty of that fault in reasoning which the writers on logick call the insufficient, or imperfect enumeration of parts, or cases: insomuch that I will venture to assert, that this is the chief, and almost the only, source of the vast number of erroneous opinions, and those too very often in matters of great importance, which we are apt to form on all the subjects we reflect upon, whether they relate to the knowledge of nature, or the merits and motives of human actions. It must therefore be acknowledged, that the art which affords a cure to this weakness, or defect, of our understandings, and teaches us to enumerate all the possible ways in which a given number of things may be mixed and combined together, that we may be certain that we have not omitted anyone arrangement of them that can lead to the object of our inquiry, deserves to be considered as most eminently useful and worthy of our highest esteem and attention. And this is the business of the art, or doctrine of combinations ... It proceeds indeed upon mathematical principles in calculating the number of the combinations of the things proposed: but by the conclusions that are obtained by it, the sagacity of the natural philosopher, the exactness of the historian, the skill and judgement of the physician, and the prudence and foresight of the politician, may be assisted; because the business of all these important professions is but to form reasonable conjectures concerning the several objects which engage their attention, and all wise conjectures are the results of a just and careful examination of the several different effects that may possibly arise from the causes that are capable of producing them.

It seems plain and self-evident, yet it needs to be said: the isolated knowledge obtained by a group of specialists in a narrow field has in itself no value whatsoever, but only in its synthesis with all the rest of knowledge and only inasmuch as it really contributes in this synthesis toward answering the demand, ‘Who are we?’

It will be possible, through the detailed determination of amino-acid sequences of hemoglobin molecules and of other molecules too, to obtain much information about the course of the evolutionary process, and to illuminate the question of the origin of species.

It would take a civilization far more advanced than ours, unbelievably advanced, to begin to manipulate negative energy to create gateways to the past. But if you could obtain large quantities of negative energy—and that's a big “IF”—then you could create a time machine that apparently obeys Einstein's equation and perhaps the laws of quantum theory.

Lately, however, on abandoning the brindled and grey mosquitos and commencing similar work on a new, brown species, of which I have as yet obtained very few individuals, I succeeded in finding in two of them certain remarkable and suspicious cells containing pigment identical in appearance to that of the parasite of malaria. As these cells appear to me to be very worthy of attention … I think it would be advisable to place on record a brief description both of the cells and of the mosquitos.

Let us suppose that an ichthyologist is exploring the life of the ocean. He casts a net into the water and brings up a fishy assortment. Surveying his catch, he proceeds in the usual manner of a scientist to systematise what it reveals. He arrives at two generalisations:
(1) No sea-creature is less than two inches long.
(2) All sea-creatures have gills.
These are both true of his catch, and he assumes tentatively that they will remain true however often he repeats it.
In applying this analogy, the catch stands for the body of knowledge which constitutes physical science, and the net for the sensory and intellectual equipment which we use in obtaining it. The casting of the net corresponds to observation; for knowledge which has not been or could not be obtained by observation is not admitted into physical science.
An onlooker may object that the first generalisation is wrong. “There are plenty of sea-creatures under two inches long, only your net is not adapted to catch them.” The icthyologist dismisses this objection contemptuously. “Anything uncatchable by my net is ipso facto outside the scope of icthyological knowledge. In short, what my net can't catch isn't fish.” Or—to translate the analogy—“If you are not simply guessing, you are claiming a knowledge of the physical universe discovered in some other way than by the methods of physical science, and admittedly unverifiable by such methods. You are a metaphysician. Bah!”

Linnaeus had it constantly in mind:“The closer we get to know the creatures around us, the clearer is the understanding we obtain of the chain of nature, and its harmony and system, according to which all things appear to have been created.”

LOGIC, n. The art of thinking and reasoning in strict accordance with the limitations and incapacities of the human misunderstanding. The basic of logic is the syllogism, consisting of a major and a minor premise and a conclusion—thus:
Major Premise: Sixty men can do a piece of work sixty times as quickly as one man.
Minor Premise: One man can dig a post-hole in sixty seconds; therefore—
Conclusion: Sixty men can dig a post-hole in one second.
This may be called the syllogism arithmetical, in which, by combining logic and mathematics, we obtain a double certainty and are twice blessed.

Looking at the thunder machine which had been set up, I saw not the slightest indication of the presence of electricity. However, while they were putting the food on the table, I obtained extraordinary electric sparks from the wire. My wife and others approached from it, for the reason that I wished to have witnesses see the various colors of fire about which the departed Professor Richmann used to argue with me. Suddenly it thundered most violently at the exact time that I was holding my hand to the metal, and sparks crackled. All fled away from me, and my wife implored that I go away. Curiosity kept me there two or three minutes more, until they told me that the soup was getting cold. By that time the force of electricity greatly subsided. I had sat at table only a few minutes when the man servant of the departed Richmann suddenly opened the door, all in tears and out of breath from fear. I thought that some one had beaten him as he was on his way to me, but he said, with difficulty, that the professor had been injured by thunder… . Nonetheless, Mr. Richmann died a splendid death, fulfilling a duty of his profession.

Mathematics is much more than a language for dealing with the physical world. It is a source of models and abstractions which will enable us to obtain amazing new insights into the way in which nature operates. Indeed, the beauty and elegance of the physical laws themselves are only apparent when expressed in the appropriate mathematical framework.

Meanwhile I flatter myself with so much success, that: students... will not be so easily mistaken in the subjects of the mineral kingdom, as has happened with me and others in following former systems; and I also hope to obtain some protectors against those who are so possessed with the figuromania, and so addicted to the surface of things, that they are shocked at the boldness of calling a marble a limestone, and of placing the Porphyry amongst the Saxa.

Medicine deals with the states of health and disease in the human body. It is a truism of philosophy that a complete knowledge of a thing can only be obtained by elucidating its causes and antecedents, provided, of course, such causes exist. In medicine it is, therefore, necessary that causes of both health and disease should be determined.

Most of the arts, as painting, sculpture, and music, have emotional appeal to the general public. This is because these arts can be experienced by some one or more of our senses. Such is not true of the art of mathematics; this art can be appreciated only by mathematicians, and to become a mathematician requires a long period of intensive training. The community of mathematicians is similar to an imaginary community of musical composers whose only satisfaction is obtained by the interchange among themselves of the musical scores they compose.

My belief (is) that one should take a minimum of care and preparation over first experiments. If they are unsuccessful one is not then discouraged since many possible reasons for failure can be thought of, and improvements can be made. Much can often be learned by the repetition under different conditions, even if the desired result is not obtained. If every conceivable precaution is taken at first, one is often too discouraged to proceed at all.

My experiments with single traits all lead to the same result: that from the seeds of hybrids, plants are obtained half of which in turn carry the hybrid trait (Aa), the other half, however, receive the parental traits A and a in equal amounts. Thus, on the average, among four plants two have the hybrid trait Aa, one the parental trait A, and the other the parental trait a. Therefore, 2Aa+ A +a or A + 2Aa + a is the empirical simple series for two differing traits.

My view of the matter, for what it is worth, is that there is no such thing as a logical method of having new ideas, or a logical reconstruction of this process. My view may be expressed by saying that every discovery contains an “irrational element,” or “a creative intuition,” in Bergson's sense. In a similar way Einstein speaks of the “search for those highly universal laws … from which a picture of the world can be obtained by pure deduction. There is no logical path.” he says, “leading to these … laws. They can only be reached by intuition, based upon something like an intellectual love (Einfühlung) of the objects of experience.”

No place affords a more striking conviction of the vanity of human hopes than a publick library; for who can see the wall crouded on every side by mighty volumes, the works of laborious meditation, and accurate inquiry, now scarcely known but by the catalogue, and preserved only to encrease the pomp of learning, without considering how many hours have been wasted in vain endeavours, how often imagination has anticipated the praises of futurity, how many statues have risen to the eye of vanity, how many ideal converts have elevated zeal, how often wit has exulted in the eternal infamy of his antagonists, and dogmatism has delighted in the gradual advances of his authority, the immutability of his decrees, and the perpetuity of his power.
Non unquam dedit
Documenta fors majora, quam fragili loco
Starent superbi.
Seneca, Troades, II, 4-6
Insulting chance ne'er call'd with louder voice,
On swelling mortals to be proud no more.
Of the innumerable authors whose performances are thus treasured up in magnificent obscurity, most are forgotten, because they never deserved to be remembered, and owed the honours which they have once obtained, not to judgment or to genius, to labour or to art, but to the prejudice of faction, the stratagem of intrigue, or the servility of adulation.
Nothing is more common than to find men whose works are now totally neglected, mentioned with praises by their contemporaries, as the oracles of their age, and the legislators of science. Curiosity is naturally excited, their volumes after long enquiry are found, but seldom reward the labour of the search. Every period of time has produced these bubbles of artificial fame, which are kept up a while by the breath of fashion and then break at once and are annihilated. The learned often bewail the loss of ancient writers whose characters have survived their works; but perhaps if we could now retrieve them we should find them only the Granvilles, Montagus, Stepneys, and Sheffields of their time, and wonder by what infatuation or caprice they could be raised to notice.
It cannot, however, be denied, that many have sunk into oblivion, whom it were unjust to number with this despicable class. Various kinds of literary fame seem destined to various measures of duration. Some spread into exuberance with a very speedy growth, but soon wither and decay; some rise more slowly, but last long. Parnassus has its flowers of transient fragrance as well as its oaks of towering height, and its laurels of eternal verdure.

No subject of philosophical inquiry within the limits of human investigation is more calculated to excite admiration and to awaken curiosity than fire; and there is certainly none more extensively useful to mankind. It is owing, no doubt, to our being acquainted with it from our infancy, that we are not more struck with its appearance, and more sensible of the benefits we derive from it. Almost every comfort and convenience which man by his ingenuity procures for himself is obtained by its assistance; and he is not more distinguished from the brute creation by the use of speech, than by his power over that wonderful agent.

Not one of them [formulae] can be shown to have any existence, so that the formula of one of the simplest of organic bodies is confused by the introduction of unexplained symbols for imaginary differences in the mode of combination of its elements… It would be just as reasonable to describe an oak tree as composed of blocks and chips and shavings to which it may be reduced by the hatchet, as by Dr Kolbe’s formula to describe acetic acid as containing the products which may be obtained from it by destructive influences. A Kolbe botanist would say that half the chips are united with some of the blocks by the force parenthesis; the other half joined to this group in a different way, described by a buckle; shavings stuck on to these in a third manner, comma; and finally, a compound of shavings and blocks united together by a fourth force, juxtaposition, is joined to the main body by a fifth force, full stop.

Objections … inspired Kronecker and others to attack Weierstrass’ “sequential” definition of irrationals. Nevertheless, right or wrong, Weierstrass and his school made the theory work. The most useful results they obtained have not yet been questioned, at least on the ground of their great utility in mathematical analysis and its implications, by any competent judge in his right mind. This does not mean that objections cannot be well taken: it merely calls attention to the fact that in mathematics, as in everything else, this earth is not yet to be confused with the Kingdom of Heaven, that perfection is a chimaera, and that, in the words of Crelle, we can only hope for closer and closer approximations to mathematical truth—whatever that may be, if anything—precisely as in the Weierstrassian theory of convergent sequences of rationals defining irrationals.

One can ask: “If I crystallize a virus to obtain a crystal consisting of the molecules that make up the virus, are those molecules lifeless or not?” … The properties of living organisms are those of aggregates of molecules. It’s very difficult to draw a line between molecules that are lifeless and molecules that are not lifeless.

One of the many useful properties of giant nerve fibres is that samples of protoplasm or axoplasm as it is usually called can be obtained by squeezing out the contents from a cut end … As in many other cells there is a high concentration of potassium ions and relatively low concentration of sodium and chloride ions. This is the reverse of the situation in the animals’ blood or in sea water, where sodium and chloride are the dominant ions and potassium is relatively dilute.

One should guard against inculcating a young man with the idea that success is the aim of life, for a successful man normally receives from his peers an incomparably greater portion than the services he has been able to render them deserve. The value of a man resides in what he gives and not in what he is capable of receiving. The most important motive for study at school, at the university, and in life is the pleasure of working and thereby obtaining results which will serve the community. The most important task for our educators is to awaken and encourage these psychological forces in a young man {or woman}. Such a basis alone can lead to the joy of possessing one of the most precious assets in the world - knowledge or artistic skill.

Our commercial and mercantile law was no sudden invention. It was not the work of a day, or of one set of minds… In the incipient, the early existence of this system, a single maxim obtained force, others succeeded; one rule of right formed a nucleus around which other kindred rules might cling; the necessities of trade originated customs, customs ripened into law; a few feeble decisions of courts laid the foundation for others; the wisdom and experience of each succeeding generation improved upon the wisdom and experience of generations that were past; and thus the edifice arose, perfect in its parts, beautiful in its proportions.

Over the last century, physicists have used light quanta, electrons, alpha particles, X-rays, gamma-rays, protons, neutrons and exotic sub-nuclear particles for this purpose [scattering experiments]. Much important information about the target atoms or nuclei or their assemblage has been obtained in this way. In witness of this importance one can point to the unusual concentration of scattering enthusiasts among earlier Nobel Laureate physicists. One could say that physicists just love to perform or interpret scattering experiments.

Peace cannot be obtained by wishing for it. We live in the same world with Russia, whose leader has said he “wants to bury us”—and he means it. Disarmament, the cessation of tests, will not automatically bring us closer to peace.

Positive, objective knowledge is public property. It can be transmitted directly from one person to another, it can be pooled, and it can be passed on from one generation to the next. Consequently, knowledge accumulates through the ages, each generation adding its contribution. Values are quite different. By values, I mean the standards by which we judge the significance of life. The meaning of good and evil, of joy and sorrow, of beauty, justice, success-all these are purely private convictions, and they constitute our store of wisdom. They are peculiar to the individual, and no methods exist by which universal agreement can be obtained. Therefore, wisdom cannot be readily transmitted from person to person, and there is no great accumulation through the ages. Each man starts from scratch and acquires his own wisdom from his own experience. About all that can be done in the way of communication is to expose others to vicarious experience in the hope of a favorable response.