“True is it, my incorporate friends,” quoth he, “That I receive the general food at first, Which you do live upon; and fit it is, Because I am the storehouse and the shop Of the whole body. But, if you do remember, I send it through the rivers of your blood, Even to the court, the heart, to th’ seat o’ th’ brain; And, through the cranks and offices of man, The strongest nerves and small inferior veins From me receive that natural competency Whereby they live. And though that all at once”— You, good friends, this says the belly, mark me.

[1665-06-10] ...In the evening home to supper, and there to my great trouble hear that the plague is come into the City (though it hath these three or four weeks since its beginning been wholly out of the City); but where it begin but in my good friend and neighbour's, Dr Burnett in Fanchurch Street - which in both points troubles me mightily. To the office to finish my letters, and then home to bed, being troubled at the sickness ... and particularly how to put my things and estate in order, in case it should please God to call me away.

[1665-06-15] ...The town grows very sickly, and people to be afeared of it - there dying this last week of the plague 112, from 43 the week before - whereof, one in Fanchurch-street and one in Broadstreete by the Treasurer's office.

[Blackett] came one morning, deep in thought, into the G (technical) Office at Stanmore. It was a bitterly cold day, and the staff were shivering in a garret warmed over only with an oil-stove. Without a word of greeting, Blackett stepped silently up on to the table and stood there pondering with his feet among the plans. After ten minutes somebody coughed uneasily and said, diffidently: “Wouldn’t you like a chair, sir … or something?” “No, thank you,” said Professor Blackett, “it is necessary to apply scientific methods. Hot air rises. The warmest spot in this room, therefore, will be near the ceiling.” At this, Colonel Krohn, my technical G.S.O., stepped up on the table beside the Professor, and for the next half-hour, the two stayed there in silence. At the end of this period Professor Blackett stepped down from the table saying: “Well! That’s that problem solved.” And so it was.

A complete and generous education fits a man to perform justly, skilfully and magnanimously all the offices of peace and war.

A very sincere and serious freshman student came to my office with a question that had clearly been troubling him deeply. He said to me, ‘I am a devout Christian and have never had any reason to doubt evolution, an idea that seems both exciting and well documented. But my roommate, a proselytizing evangelical, has been insisting with enormous vigor that I cannot be both a real Christian and an evolutionist. So tell me, can a person believe both in God and in evolution?’ Again, I gulped hard, did my intellectual duty, a nd reassured him that evolution was both true and entirely compatible with Christian belief –a position that I hold sincerely, but still an odd situation for a Jewish agnostic.

Ask a follower of Bacon what [science] the new philosophy, as it was called in the time of Charles the Second, has effected for mankind, and his answer is ready; “It has lengthened life; it has mitigated pain; it has extinguished diseases; it has increased the fertility of the soil; it has given new securities to the mariner; it has furnished new arms to the warrior; it has spanned great rivers and estuaries with bridges of form unknown to our fathers; it has guided the thunderbolt innocuously from heaven to earth; it has lighted up the night with the splendour of the day; it has extended the range of the human vision; it has multiplied the power of the human muscles; it has accelerated motion; it has annihilated distance; it has facilitated intercourse, correspondence, all friendly offices, all dispatch of business; it has enabled man to descend to the depths of the sea, to soar into the air, to penetrate securely into the noxious recesses of the earth, to traverse the land in cars which whirl along without horses, to cross the ocean in ships which run ten knots an hour against the wind. These are but a part of its fruits, and of its first-fruits; for it is a philosophy which never rests, which has never attained, which is never perfect. Its law is progress. A point which yesterday was invisible is its goal to-day, and will be its starting-point to-morrow.”

Astrology is framed by the devil, to the end people may be scared from entering into the state of matrimony, and from every divine and human office and calling.

BRAIN, n. An apparatus with which we think that we think. That which distinguishes the man who is content to be something from the man who wishes to do something. A man of great wealth, or one who has been pitchforked into high station, has commonly such a headful of brain that his neighbors cannot keep their hats on. In our civilization, and under our republican form of government, brain is so highly honored that it is rewarded by exemption from the cares of office.

But the office of the Cerebral seems to be for the animal Spirits to supply some Nerves; by which involuntary actions (such as are the beating of the Heart, easie respiration, the Concoction of the Aliment, the protrusion of the Chyle, and many others) which are made after a constant manner unknown to us, or whether we will or no, are performed.

Confined to its true domain, mathematical reasoning is admirably adapted to perform the universal office of sound logic: to induce in order to deduce, in order to construct. … It contents itself to furnish, in the most favorable domain, a model of clearness, of precision, and consistency, the close contemplation of which is alone able to prepare the mind to render other conceptions also as perfect as their nature permits. Its general reaction, more negative than positive, must consist, above all, in inspiring us everywhere with an invincible aversion for vagueness, inconsistency, and obscurity, which may always be really avoided in any reasoning whatsoever, if we make sufficient effort.

Geometrical reasoning, and arithmetical process, have each its own office: to mix the two in elementary instruction, is injurious to the proper acquisition of both.

Good teachers deserve apples; great teachers deserve chocolate.
A favorite quotation, written in calligraphy on his office door.

Great minds don't think alike. If they did, the Patent Office would only have about fifty inventions.

I beg to introduce myself to you as a clerk in the Accounts Department of the Port Trust Office at Madras on a salary of only £20 per annum. I am now about 23 years of age. … After leaving school I have been employing the spare time at my disposal to work at Mathematics.

I observed that plants not only have a faculty to correct bad air in six to ten days, by growing in it…but that they perform this important office in a complete manner in a few hours; that this wonderful operation is by no means owing to the vegetation of the plant, but to the influence of light of the sun upon the plant.

I was sitting in a chair in the patent office at Bern when all of a sudden a thought occurred to me: “If a person falls freely he will not feel his own weight.” I was startled. This simple thought made a deep impression on me. It impelled me toward a theory of gravitation.

I, Galileo Galilei, son of the late Vincenzo Galilei, of Florence, aged seventy years, being brought personally to judgment, and kneeling before your Most Eminent and Most Reverend Lords Cardinals, General Inquisitors of the universal Christian republic against heretical depravity, having before my eyes the Holy Gospels, which I touch with my own hands, swear that I have always believed, and now believe, and with the help of God will in future believe, every article which the Holy Catholic and Apostolic Church of Rome holds, teaches, and preaches. But because I have been enjoined by this Holy Office altogether to abandon the false opinion which maintains that the sun is the centre and immovable, and forbidden to hold, defend, or teach the said false doctrine in any manner, and after it hath been signified to me that the said doctrine is repugnant with the Holy Scripture, I have written and printed a book, in which I treat of the same doctrine now condemned, and adduce reasons with great force in support of the same, without giving any solution, and therefore have been judged grievously suspected of heresy; that is to say, that I held and believed that the sun is the centre of the universe and is immovable, and that the earth is not the centre and is movable; willing, therefore, to remove from the minds of your Eminences, and of every Catholic Christian, this vehement suspicion rightfully entertained toward me, with a sincere heart and unfeigned faith, I abjure, curse, and detest the said errors and heresies, and generally every other error and sect contrary to Holy Church; and I swear that I will never more in future say or assert anything verbally, or in writing, which may give rise to a similar suspicion of me; but if I shall know any heretic, or anyone suspected of heresy, that I will denounce him to this Holy Office, or to the Inquisitor or Ordinary of the place where I may be; I swear, moreover, and promise, that I will fulfil and observe fully, all the penances which have been or shall be laid on me by this Holy Office. But if it shall happen that I violate any of my said promises, oaths, and protestations (which God avert!), I subject myself to all the pains and punishments which have been decreed and promulgated by the sacred canons, and other general and particular constitutions, against delinquents of this description. So may God help me, and his Holy Gospels which I touch with my own hands. I, the above-named Galileo Galilei, have abjured, sworn, promised, and bound myself as above, and in witness thereof with my own hand have subscribed this present writing of my abjuration, which I have recited word for word. At Rome, in the Convent of Minerva, June 22, 1633. I, Galileo Galilei, have abjured as above with my own hand.

In 1945, therefore, I proved a sentimental fool; and Mr. Truman could safely have classified me among the whimpering idiots he did not wish admitted to the presidential office. For I felt that no man has the right to decree so much suffering, and that science, in providing and sharpening the knife and in upholding the ram, had incurred a guilt of which it will never get rid. It was at that time that the nexus between science and murder became clear to me. For several years after the somber event, between 1947 and 1952, I tried desperately to find a position in what then appeared to me as a bucolic Switzerland,—but I had no success.

In at least two-thirds of the American States one of the easiest ways to get into public office is to denounce him [Charles Darwin] as a scoundrel. But by the year 2030, I daresay, what remains of his doctrine, if anything, will be accepted as complacently as the Copernican cosmography is now accepted.

In England, philosophers are honoured, respected; they rise to public offices, they are buried with the kings... In France warrants are issued against them, they are persecuted, pelted with pastoral letters: Do we see that England is any the worse for it?

In Melvin Calvin’s office there were four photographs: Michael Polanyi, Joel Hildebrand, Gilbert N. Lewis, and Ernest O. Lawrence. These scientists were his mentors: Polanyi for introducing him to the chemistry of phthalocyanine; Hildebrand for bringing him to Berkeley; Lewis, perhaps his most influential teacher; and Lawrence, who provided him the opportunity to work with the new scientific tool of radioactive carbon, which enabled the search for the path of carbon in photosynthesis to be successful.

In the beginning, there was benzene!
[Written over Thiele’s office door. His former student Heinrich Otto Wieland said it expressed Thiele’s disdain for the chemistry of natural products.]

It has occurred to me that possibly the white corpuscles may have the office of picking up and digesting bacterial organisms when by any means they find their way into the blood. The propensity exhibited by the leukocytes for picking up inorganic granules is well known, and that they may be able not only to pick up but to assimilate, and so dispose of, the bacteria which come in their way does not seem to me very improbable in view of the fact that amoebae, which resemble them so closely, feed upon bacteria and similar organisms.

It is a happy world after all. The air, the earth, the water teem with delighted existence. In a spring noon, or a summer evening, on whichever side I turn my eyes, myriads of happy beings crowd upon my view. “The insect youth are on the wing.” Swarms of new-born flies are trying their pinions in the air. Their sportive motions, their wanton mazes, their gratuitous activity testify their joy and the exultation they feel in their lately discovered faculties … The whole winged insect tribe, it is probable, are equally intent upon their proper employments, and under every variety of constitution, gratified, and perhaps equally gratified, by the offices which the author of their nature has assigned to them.

It is by the aid of iron that we construct houses, cleave rocks, and perform so many other useful offices of life. But it is with iron also that wars, murders, and robberies are effected, and this, not only hand to hand, but from a distance even, by the aid of missiles and winged weapons, now launched from engines, now hurled by the human arm, and now furnished with feathery wings. This last I regard as the most criminal artifice that has been devised by the human mind; for, as if to bring death upon man with still greater rapidity, we have given wings to iron and taught it to fly. ... Nature, in conformity with her usual benevolence, has limited the power of iron, by inflicting upon it the punishment of rust; and has thus displayed her usual foresight in rendering nothing in existence more perishable, than the substance which brings the greatest dangers upon perishable mortality.

It is for these reasons that I regard the decision last year to shift our efforts in space from low to high gear as among the most important decisions that will be made during my incumbency in the office of the Presidency.

It is inaccurate to say I hate everything. I am strongly in favor of common sense, common honesty, and common decency. This makes me forever ineligible for any public office.

It is not surprising, in view of the polydynamic constitution of the genuinely mathematical mind, that many of the major heros of the science, men like Desargues and Pascal, Descartes and Leibnitz, Newton, Gauss and Bolzano, Helmholtz and Clifford, Riemann and Salmon and Plücker and Poincaré, have attained to high distinction in other fields not only of science but of philosophy and letters too. And when we reflect that the very greatest mathematical achievements have been due, not alone to the peering, microscopic, histologic vision of men like Weierstrass, illuminating the hidden recesses, the minute and intimate structure of logical reality, but to the larger vision also of men like Klein who survey the kingdoms of geometry and analysis for the endless variety of things that flourish there, as the eye of Darwin ranged over the flora and fauna of the world, or as a commercial monarch contemplates its industry, or as a statesman beholds an empire; when we reflect not only that the Calculus of Probability is a creation of mathematics but that the master mathematician is constantly required to exercise judgment—judgment, that is, in matters not admitting of certainty—balancing probabilities not yet reduced nor even reducible perhaps to calculation; when we reflect that he is called upon to exercise a function analogous to that of the comparative anatomist like Cuvier, comparing theories and doctrines of every degree of similarity and dissimilarity of structure; when, finally, we reflect that he seldom deals with a single idea at a tune, but is for the most part engaged in wielding organized hosts of them, as a general wields at once the division of an army or as a great civil administrator directs from his central office diverse and scattered but related groups of interests and operations; then, I say, the current opinion that devotion to mathematics unfits the devotee for practical affairs should be known for false on a priori grounds. And one should be thus prepared to find that as a fact Gaspard Monge, creator of descriptive geometry, author of the classic Applications de l’analyse à la géométrie; Lazare Carnot, author of the celebrated works, Géométrie de position, and Réflections sur la Métaphysique du Calcul infinitesimal; Fourier, immortal creator of the Théorie analytique de la chaleur; Arago, rightful inheritor of Monge’s chair of geometry; Poncelet, creator of pure projective geometry; one should not be surprised, I say, to find that these and other mathematicians in a land sagacious enough to invoke their aid, rendered, alike in peace and in war, eminent public service.

It is the object of science to replace, or save, experiences, by the reproduction and anticipation of facts in thought. Memory is handier than experience, and often answers the same purpose. This economical office of science, which fills its whole life, is apparent at first glance; and with its full recognition all mysticism in science disappears.

Man is but a perambulating tool-box and workshop or office, fashioned for itself by a piece of very clever slime, as the result of long experience. ... Hence we speak of man's body as his “trunk.”

Men have been talking now for a week at the post office about the age of the great elm, as a matter interesting but impossible to be determined. The very choppers and travelers have stood upon its prostrate trunk and speculated upon its age, as if it were a profound mystery. I stooped and read its years to them (127 at nine and a half feet), but they heard me as the wind that once sighed through its branches. They still surmised that it might be two hundred years old, but they never stooped to read the inscription. Truly they love darkness rather than light. One said it was probably one hundred and fifty, for he had heard somebody say that for fifty years the elm grew, for fifty it stood still, and for fifty it was dying. (Wonder what portion of his career he stood still!) Truly all men are not men of science. They dwell within an integument of prejudice thicker than the bark of the cork-tree, but it is valuable chiefly to stop bottles with. Tied to their buoyant prejudices, they keep themselves afloat when honest swimmers sink.

Mr. Thomas A. Edison recently came into this office, placed a little machine on our desk, turned a crank, and the machine enquired as to our health, asked how we liked the phonograph, informed us that it was well, and bid us a cordial good night. These remarks were not only perfectly audible to ourselves, but to a dozen or more persons gathered around.

My father introduced me to three black men who had earned doctorates in chemistry and physics. The best jobs they could find were at the post office. My father said I was taking the long road toward working at the post office.

Neil and Buzz, I am talking to you by telephone from the Oval Office at the White House, and this certainly has to be the most historic telephone call ever made. Because of what you have done, the heavens have become a part of man’s world. As you talk to us from the Sea of Tranquility, it inspires us to redouble our efforts to bring peace and tranquility to Earth.

Never go to a doctor whose office plants have died.

Nothing could be more admirable than the manner in which for forty years he [Joseph Black] performed this useful and dignified office. His style of lecturing was as nearly perfect as can well be conceived; for it had all the simplicity which is so entirely suited to scientific discourse, while it partook largely of the elegance which characterized all he said or did … I have heard the greatest understandings of the age giving forth their efforts in its most eloquent tongues—have heard the commanding periods of Pitt’s majestic oratory—the vehemence of Fox’s burning declamation—have followed the close-compacted chain of Grant’s pure reasoning—been carried away by the mingled fancy, epigram, and argumentation of Plunket; but I should without hesitation prefer, for mere intellectual gratification (though aware how much of it is derived from association), to be once more allowed the privilege which I in those days enjoyed of being present while the first philosopher of his age was the historian of his own discoveries, and be an eyewitness of those experiments by which he had formerly made them, once more performed with his own hands.

Reason is, and ought only to be the slave of the passions, and can never pretend to any other office than to serve and obey them.

So there he is at last. Man on the moon. The poor magnificent bungler! He can't even get to the office without undergoing the agonies of the damned, but give him a little metal, a few chemicals, some wire and twenty or thirty billion dollars and, vroom! there he is, up on a rock a quarter of a million miles up in the sky.
[Written when the first manned mission to the Moon, Apollo 11, landed (20 Jul 1969).]

Someone poring over the old files in the United States Patent Office at Washington the other day found a letter written in 1833 that illustrates the limitations of the human imagination. It was from an old employee of the Patent Office, offering his resignation to the head of the department His reason was that as everything inventable had been invented the Patent Office would soon be discontinued and there would be no further need of his services or the services of any of his fellow clerks. He, therefore, decided to leave before the blow fell.

That Mettals, Small Stones, Rocky-Stones, Sulphurs, Salts, and so the whole rank of Minerals, do find their Seeds in the Matrix or Womb of the Waters, which contain the Reasons, Gifts, Knowledges, Progresses, Appointments, Offices, and Durations of the same.

That reminds me to remark, in passing, that the very first official thing I did, in my administration—and it was on the first day of it, too—was to start a patent office; for I knew that a country without a patent office and good patent laws was just a crab, and couldn't travel any way but sideways or backways.

The brain is a wonderful organ. It starts working the moment you get up in the morning and does not stop until you get into the office.

The Commissioner of Patents may be likened to a wine merchant. He has in his office the wine of human progress of every kind and quality—wine, one may say, produced from the fermentation of the facts of the world through the yeast of human effort. Sometimes the yeast is “wild” and sometimes the “must” is poor, and while it all lies there shining with its due measure of the sparkle of divine effort, it is but occasionally that one finds a wine whose bouquet is the result of a pure culture on the true fruit of knowledge. But it is this true, pure wine of discovery that is alone of lasting significance.

The fact that stares one in the face is that people of the greatest sincerity and of all levels of intelligence differ and have always differed in their religious beliefs. Since at most one faith can be true, it follows that human beings are extremely liable to believe firmly and honestly in something untrue in the field of revealed religion. One would have expected this obvious fact to lead to some humility, to some thought that however deep one's faith, one may conceivably be mistaken. Nothing is further from the believer, any believer, than this elementary humility. All in his power … must have his faith rammed down their throats. In many cases children are indeed indoctrinated with the disgraceful thought that they belong to the one group with superior knowledge who alone have a private wire to the office of the Almighty, all others being less fortunate than they themselves.

The Grand Duke [of Tuscany] …after observing the Medicaean plants several times with me … has now invited me to attach myself to him with the annual salary of one thousand florins, and with the title of Philosopher and Principal Mathematicial to His Highness; without the duties of office to perform, but with the most complete leisure; so that I can complete my Treatises...

The members of the department became like the Athenians who, according to the Apostle Paul, “spent their time in nothing else, but either to tell or to hear some new thing.” Anyone who thought he had a bright idea rushed out to try it out on a colleague. Groups of two or more could be seen every day in offices, before blackboards or even in corridors, arguing vehemently about these 'brain storms.' It is doubtful whether any paper ever emerged for publication that had not run the gauntlet of such criticism. The whole department thus became far greater than the sum of its individual members.

The men you see waiting in the lobbies of doctors’ offices are, in a vast majority of cases, suffering through poisoning caused by an excess of food.

The need for a quick, satisfactory copying machine that could be used right in the office seemed very apparent to me—there seemed such a crying need for it—such a desirable thing if it could be obtained. So I set out to think of how one could be made.

The office of science is not to record possibilities; but to ascertain what nature does ... As far as Darwinism deals with mere arguments of possibilities or even probabilities, without a basis of fact, it departs from the true scientific method and injures science, as most of the devotees of the new ism have already done.

The office of the leisure class in social evolution is to retard movement and to conserve what is obsolescent.

The Patent Office is the mother-in-law of invention.

The Patent-Office Commissioner knows that all machines in use have been invented and re-invented over and over; that the mariner’s compass, the boat, the pendulum, glass, movable types, the kaleidoscope, the railway, the power-loom, etc., have been many times found and lost, from Egypt, China and Pompeii down; and if we have arts which Rome wanted, so also Rome had arts which we have lost; that the invention of yesterday of making wood indestructible by means of vapor of coal-oil or paraffine was suggested by the Egyptian method which has preserved its mummy-cases four thousand years.

The persons who have been employed on these problems of applying the properties of matter and the laws of motion to the explanation of the phenomena of the world, and who have brought to them the high and admirable qualities which such an office requires, have justly excited in a very eminent degree the admiration which mankind feels for great intellectual powers. Their names occupy a distinguished place in literary history; and probably there are no scientific reputations of the last century higher, and none more merited, than those earned by great mathematicians who have laboured with such wonderful success in unfolding the mechanism of the heavens; such for instance as D ’Alembert, Clairaut, Euler, Lagrange, Laplace.

The poets did well to conjoin music and medicine, in Apollo, because the office of medicine is but to tune the curious harp of man's body and reduce it to harmony.

The Post Office Committee of the House has referred to a sub-committee all the bills authorizing the building or buying of telegraph lines for the purpose of establishing a postal telegraph—that is, of sending mails by electricity … All is done by contract … with the carriage of mails by steam power [railroads] … It does not appear why there should be any difference of principle because of the substitution of electricity for steam.
[Foreshadowing email.]

The powers which tend to preserve, and those which tend to change the condition of the earth's surface, are never in equilibrio; the latter are, in all cases, the most powerful, and, in respect of the former, are like living in comparison of dead forces. Hence the law of decay is one which suffers no exception: The elements of all bodies were once loose and unconnected, and to the same state nature has appointed that they should all return... TIME performs the office of integrating the infinitesimal parts of which this progression is made up; it collects them into one sum, and produces from them an amount greater than any that can be assigned.

The Royal Society is a collection of men who elect each other to office and then dine together at the expense of the Society to praise each other over wine and award each other medals.

There cannot be design without a designer; contrivance without a contriver; order without choice; arrangement, without any thing capable of arranging; subserviency and relation to a purpose; means suitable to an end, and executing their office in accomplishing that end, without the end ever having been contemplated, or the means accommodated to it. Arrangement, disposition of parts, subserviency of means to an end, relation of instruments to use, imply the preference of intelligence and mind.

There is a story that once, not long after he came to Berlin, Planck forgot which room had been assigned to him for a lecture and stopped at the entrance office of the university to find out. Please tell me, he asked the elderly man in charge, “In which room does Professor Planck lecture today?” The old man patted him on the shoulder “Don't go there, young fellow,” he said “You are much too young to understand the lectures of our learned Professor Planck.”

Thinking is the activity I love best, and writing to me is simply thinking through my fingers. I can write up to 18 hours a day. Typing 90 words a minute, I’ve done better than 50 pages a day. Nothing interferes with my concentration. You could put an orgy in my office and I wouldn't look up—well, maybe once.

This sceptred isle,…
This fortress built by Nature for herself…
This precious stone set in the silver sea,
Which serves it in the office of a wall
Or as a moat defensive to a house,
Against the envy of less happier lands,
This blessed plot, this earth, this realm, this England.

To get your name well enough known that you can run for a public office, some people do it by being great lawyers or philanthropists or business people or work their way up the political ladder. I happened to become known from a different route.

To the Victorian scientist, science was the pursuit of truth about Nature. In imagination, each new truth discovered could be ticked off on a list kept perhaps in a celestial planning office, so reducing by one the total number of truths to be discovered. But the practising scientist now knows that he is dealing with a living, growing thing. His task is never done.

We [Irving Kaplansky and Paul Halmos] share a philosophy about linear algebra: we think basis-free, we write basis-free , but when the chips are down we close the office door and compute with matrices like fury.

We must raise the salaries of our operators or they will all be taken from us, that is, all that are good for anything. You will recollect that, at the first meeting of the Board of Directors, I took the ground that 'it was our policy to make the office of operator desirable, to pay operators well and make their situation so agreeable that intelligent men and men of character will seek the place and dread to lose it.' I still think so, and, depend upon it, it is the soundest economy to act on this principle.

Well do I remember that dark hot little office in the hospital at Begumpett, with the necessary gleam of light coming in from under the eaves of the veranda. I did not allow the punka to be used because it blew about my dissected mosquitoes, which were partly examined without a cover-glass; and the result was that swarms of flies and of 'eye-flies' - minute little insects which try to get into one's ears and eyelids - tormented me at their pleasure

What was Freud’s Galapagos, what species fluttered what kinds of wings before his searching eyes? It has often been pointed out derisively: his creative laboratory was the neurologist’s office, the dominant species hysterical ladies.

When I saw the alpha-helix and saw what a beautiful, elegant structure it was, I was thunderstruck and was furious with myself for not having built this, but on the other hand, I wondered, was it really right?
So I cycled home for lunch and was so preoccupied with the turmoil in my mind that didn’t respond to anything. Then I had an idea, so I cycled back to the lab. I realized that I had a horse hair in a drawer. I set it up on the X-ray camera and gave it a two hour exposure, then took the film to the dark room with my heart in my mouth, wondering what it showed, and when I developed it, there was the 1.5 angstrom reflection which I had predicted and which excluded all structures other than the alpha-helix.
So on Monday morning I stormed into my professor’s office, into Bragg’s office and showed him this, and Bragg said, 'Whatever made you think of that?' And I said, 'Because I was so furious with myself for having missed that beautiful structure.' To which Bragg replied coldly, 'I wish I had made you angry earlier.'

When in many dissections, carried out as opportunity offered upon living animals, I first addressed my mind to seeing how I could discover the function and offices of the heart’s movement in animals through the use of my own eyes instead of through the books and writings of others, I kept finding the matter so truly hard and beset with difficulties that I all but thought, with Fracastoro, that the heart's movement had been understood by God alone.

While reading in a textbook of chemistry, … I came across the statement, “nitric acid acts upon copper.” I was getting tired of reading such absurd stuff and I determined to see what this meant. Copper was more or less familiar to me, for copper cents were then in use. I had seen a bottle marked “nitric acid” on a table in the doctor’s office where I was then “doing time.” I did not know its peculiarities, but I was getting on and likely to learn. The spirit of adventure was upon me. Having nitric acid and copper, I had only to learn what the words “act upon” meant … I put one of them [cent] on the table, opened the bottle marked “nitric acid”; poured some of the liquid on the copper; and prepared to make an observation. But what was this wonderful thing which I beheld? The cent was already changed, and it was no small change either. A greenish blue liquid foamed and fumed over the cent and over the table. The air in the neighborhood of the performance became colored dark red. A great colored cloud arose. This was disagreeable and suffocating—how should I stop this? I tried to get rid of the objectionable mess by picking it up and throwing it out of the window, which I had meanwhile opened. I learned another fact—nitric acid not only acts upon copper but it acts upon fingers. The pain led to another unpremeditated experiment. I drew my fingers across my trousers and another fact was discovered. Nitric acid acts upon trousers. Taking everything into consideration, that was the most impressive experiment, and, relatively, probably the most costly experiment I have ever performed.